The drug Concor (Concor) is intended for patients with observed arterial hypertension (AH), angina pectoris (CHD) or chronic heart failure.

Pharmacological properties and action of the drug

The product acts 1-3 hours after ingestion and has a therapeutic effect during the day. With a decrease in cardiac output, it has a hypotensive effect, acting on the baroreceptors of the carotid sinus and aortic arch, inhibiting the secretion of renin by the kidneys. Side effect has an antianginal effect, increasing the supply of oxygen to the myocardium due to decreasing diastolic pressure. Significantly improves well-being in chronic heart failure.

Application and dosage*

You can take Concor only as directed by your doctor. The drug is taken orally, in the morning and on an empty stomach, swallowing and not chewing. Completely absorbed in the gastrointestinal tract and 90% excreted by the kidneys. The norm of one dose for adults is 2.5-5 mg. If necessary, the dose can be increased to 10 mg (also once a day). The maximum dose per day is 20 mg.

For patients with diseases and dysfunctions of the liver or kidneys, the norms for taking Concor are the same.

Contraindications

The drug is contraindicated in shock conditions, bradycardia, arterial hypotension, bronchial asthma, severe forms of peripheral circulation disorder, psoriasis and pheochromocytosis.

Side effects of Concor: a wide range of side effects of the drug, taking into account individual tolerance.

How Concor affects the human body

Influence on the central nervous system: increased fatigue, dizziness, headaches, sleep disturbance, rarely hallucinations.

Influence on the organs of vision: blurred vision, conjunctivitis, decreased lacrimation;

Effect on the cardiovascular system: in individual cases - bradycardia, orthostatic hypotension, conduction disturbance - AV, heart failure and the development of peripheral edema, at the beginning of the course of treatment, the condition may worsen with intermittent claudication or Raynaud's syndrome.

Influence on the respiratory system: with a tendency to bronchospasm, shortness of breath can be observed.

Effect on the digestive system: side effects in the form of constipation, diarrhea, nausea, abdominal pain.

Influence on the musculoskeletal system: in rare cases, convulsions, muscle weakness, arthropathy with joint damage (poly- or monoarthritis).

Influence on the skin in the form of dermatological reactions: in rare cases, itching, excessive sweating, skin flushing, skin rash.

During pregnancy and lactation

Overdose

Leads to bradycardia, arterial hypotension, heart failure, bronchospasm. Treatment - gastric lavage, or activated charcoal.

Combination with other drugs

Concor enhances the effect of antihypertensive drugs. With the simultaneous use of Concor with nifedipine or other calcium channel blockers, an increase in the hypotensive effect is observed.

Release form: packs of 100, 50 and 30 tablets.

Concor storage conditions: at room temperature.

* There are contraindications to the use of the drug, before using it is necessary to read the instructions for medical use and consult a doctor.

And bisoprolol fumarate in a ratio of 2:1 as active ingredients.

Excipients: calcium hydrophosphate, corn starch, colloidal silicon dioxide, microcrystalline cellulose, crospovidone, magnesium stearate.

Shell composition: hypromellose , , iron oxide yellow, macrogol 400 , titanium dioxide .

Release form

Concor tablets are coated with a light orange shell, heart-shaped, biconvex, with serifs on both edges.

Release forms for Concor (dosage 5 and 10 mg):

• ten such tablets in a blister, five or three such blisters in a carton;
• or 25 such tablets in a blister, two such blisters in a carton;
• or 30 such tablets in a blister, one such blister in a carton.

For Concor 10 mg, there is an additional form of release:

• 30 tablets in a blister, three of these blisters in a carton.

pharmachologic effect

Concor is a medicine that has antiarrhythmic, hypotensive, antianginal action.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The medical preparation Concor is selective beta-1-blocker without sympathomimetic action. This honey drug also does not have a membrane-stabilizing effect.

The use of the drug Concor does not affect the condition of the respiratory tract and metabolic processes in which beta-2-adrenergic receptors .

INN (international non-proprietary name) drugs: "bisoprolol".

It does not have a strong negative inotropic effect. Lowers tone sympathoadrenal system , suppresses beta-1-adrenergic receptors hearts.

With a single dose in patients with no chronic heart failure bisoprolol reduces the number of heartbeats, stroke volume of the heart, ejection fraction and myocardial oxygen demand. With long-term therapy, increased total peripheral vascular resistance decreases.

The maximum effect occurs three hours after administration. When appointed bisoprolol once a day, its effect lasts 24 hours. The maximum decrease in pressure is recorded 12-14 days after the start of therapy.

Pharmacokinetics

bisoprolol absorbed from the intestine by 90%. Bioavailability - 90%. Food intake does not affect bioavailability. Concentrations bisoprolol in plasma are proportional to accepted doses in the range of 5-20 mg. The highest concentration in the blood occurs 3 hours.

Plasma protein binding approaches 30%. All derivatives are excreted by the kidneys and are not pharmacologically active. The half-life is 11-12 hours.

Indications for use Concor

Indications for the use of the drug:

• chronic heart failure ;
• cardiac ischemia ;

Contraindications

Contraindications to the use of Concor:

• acute form heart failure;
• decompensated chronic heart failure;
• AV block 2-3 degrees;
• cardiogenic shock;
• sinoatrial blockade;
• bradycardia;
• a pronounced decrease in pressure;
• and COPD;
• metabolic acidosis;
• heavy changes peripheral arterial circulation;
• pheochromocytoma;
• age less than 18 years;
• to the components of the drug.

Side effects of Concor

Reviews of side effects are not uncommon, most often reporting a slow heartbeat, hypotension, nausea, and a deterioration in well-being.

• From the circulatory system: bradycardia , worsening , numbness of the extremities, a strong decrease in pressure, orthostatic hypotension .
• From the nervous system and psyche: dizziness, loss of consciousness, headache, nightmares.
• From the respiratory system: an attack.
• From the musculoskeletal system: convulsions , muscle weakness.
• From the senses: hearing loss,.
• From the digestive system: nausea, vomiting, increased levels AST and ALT in blood.
• From the genitourinary system: potency disorders.
• From the side of the skin: .
• Allergic reactions: itching, rash, redness of the skin,.

Instructions for use Concor (Method and dosage)

The instruction on Concor tablets prescribes to take the drug orally, once a day, in the morning. Instructions for use of the drug also indicate that it should be washed down with a small amount of water, without chewing.

How to take Concor for arterial hypertension and angina pectoris

The dose of pressure medication Concor is selected individually, taking into account the clinic of the disease and the patient's condition. The initial dose is 5 mg once a day. If necessary, it is increased by 5 mg once a day. In therapy and the highest recommended dose is 20 mg per day.

In chronic course heart failure the usual regimen of therapy includes the use ACE inhibitors or angiotensin blockers, diuretics, beta-blockers and cardiac glycosides.

A prerequisite for drug therapy is a stable chronic course. heart failure without exacerbations. The maximum recommended dose for the treatment of this pathology is 10 mg once a day.

At the moment, there is not enough data on the use of the drug in children, from which Concor tablets are not recommended for children under 18 years of age.

How long can the drug be taken

The abstract does not limit the duration of the drug. Authoritative Internet resources, such as Wikipedia, also do not give clear instructions on this issue, reporting only that the course of treatment is long-term and is determined by the attending physician.

There is insufficient data on the use of the drug in patients with chronic heart failure complicated by of the first type, severe lesions of the liver and kidneys, or congenital heart defects with severe hemodynamic disorders, from which the drug Concor in this category of patients should be prescribed with caution.

Overdose

Overdose symptoms: bradycardia , strong pressure drop, AV block, bronchospasm, hypoglycemia and acute heart failure.

Treatment: stop taking the medicine, start symptomatic therapy.

At bradycardia intravenous administration is indicated. With a strong decrease in pressure - intravenous administration vasopressor drugs and plasma-substituting solutions .

With an exacerbation chronic heart failure - introduction diuretics and vasodilators .

At AV block - appointment beta-agonists , if necessary - the installation of an artificial pacemaker.

At hypoglycemia - administration of glucose solution.

Interaction

Antiarrhythmic drugs first class when combined with bisoprolol can reduce the conduction and contractility of the heart.

Antihypertensive drugs taken from bisoprolol may cause bradycardia , decreased cardiac output and vasodilation .

Combinations requiring caution

Antiarrhythmic drugs 3 classes (amiodarone) and parasympathomimetics exacerbate AV conduction disturbances.

β-blockers topical application activate systemic effects bisoprolol .

Action hypoglycemic agents enhanced when used with bisoprolol .

cardiac glycosides when used together with bisoprolol lead to the development bradycardia.

Non-steroidal anti-inflammatory drugs reduce the hypotensive effect bisoprolol.

Application bisoprolol With non-selective adrenomimetics reinforces vasoconstrictor effects these funds, leading to an increase in pressure.

Mefloquine when used with bisoprolol can increase development bradycardia.

MAO inhibitors amplify hypotensive effect of beta-blockers.

Terms of sale

Released by prescription.

Storage conditions

Keep away from children. Store at temperatures up to 30 °C.

Best before date

Five years.

special instructions

Use with caution in the following cases:

• with symptoms hypoglycemia ;
• conducting desensitizing treatment;
• Prinzmetal's angina ;
• strict diet;
• mild or moderate impairment of peripheral circulation from the arteries;
• AV block first degree;

Concor's analogs

Coincidence in the ATX code of the 4th level:

Due to the relatively high price of the drug, patients often have a question: how to replace Concor. Bicard, Bisocard, Bisoprolol Sandoz, Bisoprolol-Apotex, Bisoprolol-Maxpharma, Bisoprolol-Richter, Bisoprofar, Bisostad,- this is just a small list of what Concor can replace.

There is also a Russian analogue of Concor - the drug Biprol . The medicine and its analogues are in different price categories; the price of analogs, as a rule, is lower. For example, the aforementioned Concor substitute Biprol 5 mg No. 28 will cost 133-145 rubles, which is almost three times cheaper than the drug from Merck of the same dosage.

children

With alcohol

The compatibility of Concor and alcohol is a frequent topic of discussion for patients taking this remedy. Alcohol is not compatible with any adrenoblockers due to the risk of orthostatic hypotension.

During pregnancy and lactation

Reviews about Concore

Reviews of doctors about pills for pressure Concor as a whole fit into the average picture of reports of beta-blockers. The drug has its advantages and disadvantages.

The forums also contain ample evaluations of the drug's effectiveness. The most frequently asked question: do Concor tablets lower blood pressure? It should be remembered that the effectiveness is highly dependent on the individual characteristics of each individual patient.

Nebilet or Concor - which is better?

Both drugs belong to the group of beta-blockers. from a theoretical point of view, it has a stronger vasodilating effect and more often causes undesirable effects (headaches) due to excessive vasodilating action. In this case, the drug of choice is Concor.

Egilok or Concor - which is better?

Similar in almost all respects means. One drug can be easily replaced during treatment with another. 5 mg of Concor is equivalent to 50 mg .

Lokren or Concor - which is better?

Compared to Concor, it has a more prolonged effect, greater affinity for specific receptors and, therefore, the most stable plasma concentration. Medicine prices are comparable.

Coronal or Concor - which is better?

These funds are interchangeable analogues with the same active ingredient. more affordable from a financial point of view, so the choice between drugs should be made based on considerations of economic feasibility and the individual characteristics of the patient.

Bisoprolol or Concor - which is better?

The answer to this question is identical to the previous answer. These drugs are analogues, but bisoprolol has a lower price.

What is the difference between Concor Cor and Concor?

The most common question of the comparative effectiveness of drugs: how does Concor differ from Concor Core ? Both drugs contain as an active ingredient bisoprolol . The main difference between the drugs in the presence of tablets with a dosage of 2.5 mg in Concor Cor.

Concor price, where to buy

In Russia, the price of Concor 5 mg No. 50 ranges from 306-340 rubles, buying 50 tablets of 10 mg will cost 463-575 rubles. The cost of the medicine (5 mg No. 50) in Moscow starts from 313 rubles.

The price of Concor tablets in Ukraine 10 mg No. 50 averages 162 hryvnia.

• Internet pharmacies in Russia Russia
• Internet pharmacies in Ukraine Ukraine
• Internet pharmacies of Kazakhstan Kazakhstan

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Concor cor tab. p/o captivity 2.5mg №30Merck KGaA/LLC Nanolek

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With hypertension and chronic heart failure, patients are often prescribed the drug Concor.

The mechanism of action of the drug gives a pronounced hypotensive effect, normalizes heart rhythms, improves the functioning of the heart muscle.

This medication is of great benefit to the body of hypertensive patients, but, like the bulk of therapeutic drugs, it can be dangerous for people with certain diseases.

Before taking pills for hypertension, a person needs to make sure that there are no contraindications to Concor, side effects for women and men will also not be superfluous to find out.

• cardiogenic shock;
• acute heart failure;
• decompensated heart failure in a chronic form;
• sinoatrial blockade;
• sinus node dysfunction syndrome;
• bradycardia, in which the number of heartbeats does not exceed 50 beats per minute;
• hypotension (systolic pressure does not exceed 90 millimeters of mercury);
• atrioventricular (AV) blockade of the 2nd and 3rd degree, accompanied by loss of nerve impulses between the ventricles and atria of the heart muscle (in the absence of a pacemaker);
• severe bronchial asthma;
• chronic (progressive) obstructive pulmonary disease;
• violation of metabolic processes, in which the pH of the blood and the level of bicarbonate in the blood decrease (metabolic acidosis);
• violation of peripheral circulation (Raynaud's disease and other pathological conditions);
• a significant increase in the size of the heart (cardiomegaly);
• benign or malignant tumor of the adrenal glands (pheochromocytoma);
• hypersensitivity or intolerance to any components that make up the drug.

Also, the drug should not be used by nursing mothers and children who are under 18 years of age. During pregnancy, this drug can be prescribed to a woman only if the benefit to the expectant mother is much higher than the harm to the developing fetus (all risks in such situations should be assessed by the attending physician).

It is necessary to take Concor with extreme caution and only on the recommendation of a doctor for such diseases and conditions as:

• severe liver damage (liver failure);
• kidney failure;
• diabetes;
• hyperthyroidism;
• congenital heart defects;
• myasthenia gravis;
• Prinzmetal's angina;
• atrioventricular blockade of the 1st degree;
• allergic reactions;
• psoriasis;
• frequent depression.

Elderly people need to take precautions and monitor changes in well-being, any ailments after taking Concor, side effects of any nature should be a reason to urgently consult a doctor.

Side effects of Concor

Even with proper use and strict adherence to the dosage, the drug Concor side effects can provoke the following:

1. from the gastrointestinal tract: nausea, vomiting, constipation, diarrhea, liver dysfunction, epigastric pain, dry mouth, change in taste sensations;
2. from the CNS: headaches, migraines, dizziness, loss of consciousness, weakness, fatigue, insomnia or drowsiness, nightmares, hallucinations, depressive states, causeless anxiety, panic, convulsions, memory impairment, myasthenia gravis, asthenia;
3. from the cardiovascular system: a sharp decrease in blood pressure, attacks of bradycardia, increased heart rate, angiospasm, exacerbation of chronic heart failure, numbness of the extremities;
4. by the organs of vision: increased tearing, dryness of the mucous membrane of the eyes, inflammation of the conjunctiva, blurred vision;
5. from the respiratory system: runny nose, nasal congestion, shortness of breath, bronchospasm;
6. by the sense organs: impaired or partial hearing loss;
7. from the musculoskeletal system: weakness in the muscles, leg cramps, arthralgia, pain in the back;
8. from the side of the skin: exacerbation of psoriasis, baldness, hyperhidrosis;
9. allergic reactions: itching and rashes on the skin (urticaria), swelling and redness of the skin, allergic rhinitis;
10. changes in blood parameters: an increase in the level of AST and ALT enzymes, a decrease in the number of platelets, a decrease in the level of leukocytes, an increase in the amount of triglycerides.

Side effects of Concor Cor (differs in the dosage of the active substance) are similar.

Does Concor affect potency? Side effects of Concor extend to the genitourinary system. After taking it, a weakening of potency in men is possible, a decrease in sexual desire.

To minimize the risks of adverse reactions and complications, hypertension must follow all the doctor's instructions.

Concor should be taken in accordance with the following recommendations:

• patients are not recommended to abruptly stop taking the drug (in order to complete treatment without harm to the cardiovascular system, the dosage must be reduced gradually);
• if an operation is prescribed for hypertension, he needs to reduce the dose of the drug a few days before the surgical intervention, and completely refuse to take the drug two days before (the patient is also obliged to warn the anesthesiologist in advance that he is using Concor tablets);
• people taking the drug should regularly visit a doctor so that the doctor can monitor blood pressure, heart rate, cardiogram indicators, the condition of the patient's kidneys;
• despite the fact that clinical studies have not shown that Concor affects concentration, at the beginning of treatment, the patient should be especially careful when driving a car or working with complex mechanisms (the individual reaction of the body to this drug may be unpredictable);
• a hypertensive patient wearing contact lenses should be prepared for the fact that the mucous membrane of his eyes, when taking an antihypertensive drug, may become drier and more sensitive to a foreign body.

What is better Concor or Bisprolol? Both drugs have proven high efficacy in the treatment of hypertension and cardiovascular disease, but there is a difference between them.

Bisoprolol is one of the widely used cardiac drugs. It has a positive effect in the field of cardiology, an acceptable cost. But it has bisoprolol and side effects.

The drug Concor in combination with other drugs can adversely affect the state of the human body.

• lidocaine;
• flecainide;
• quinidine;
• disopyramide;
• propafenone;
• phenytoin;
• diltiazem;
• clonidine;
• verapamil;
• rilmenidine;
• moxonidine;
• methyldop;
• felodipine;
• amlodipine;
• nifedipine;
• amiodarone;
• mefloquine.

In addition, with extreme caution, you need to use Concor in combination with anti-inflammatory non-steroidal drugs, beta-blockers, insulin and various hypoglycemic agents, parasympathomimetics, cardiac glycosides, barbiturates, antidepressants, etc. A complete list of drugs that are undesirable to use with Concor, hypertension should provide the attending physician.

Only careful adherence to the treatment regimen will give the patient the expected therapeutic effect, any deviations from the doctor's prescriptions can negatively affect not only the cardiovascular system, but also the state of the whole organism.

Related videos

How to take Concor tablets correctly, see the video:

You can read about the side effects of Concor in the reviews and make sure that everything is not so scary if you follow the instructions for use and the doctor's recommendations. The drug is considered one of the most potent drugs that help a person cope with hypertension and other diseases that affect the heart and blood vessels. In order for this drug to benefit hypertension, it must not exceed the prescribed dosage of tablets and not self-medicate. Only a specialist with a medical education who is aware of all the side effects of the drug and is always responsible for the health of his patient can prescribe and cancel Concor's intake.

The drug Concor is a selective β1-blocker. It is used in the treatment of various pathologies, including hypertension and cardiac ischemia. Due to the high efficiency of the drug, it is enough to take it once a day: the effect comes after a few hours and lasts for a whole day. The price at which you can buy Concor is about 280-350 rubles per package, which includes 50 tablets.

Indications

Concor tablets are prescribed to patients if they have any of the following diseases:

• arterial hypertension;
• ischemia of the heart;
• stable angina;
• Heart failure.

Composition, release form

Concor is presented in tablets of 5 mg and 10 mg, and Concor Cor - in tablets of 2.5 mg (and there are no other differences, except for dosages, for the drugs). Tablets are convex on both sides, having a shell. Their color ranges from yellow to orange.

The composition of the drug is as follows:

• The active ingredient is bisoprolol;
• colloidal silicon dioxide;
• magnesium stearate;
• Calcium hydrogen phosphate;
• Cellulose microcrystals;
• Corn starch;
• Crospovidone.

Beneficial features

Being a selective β1-blocker, Concor has 3 beneficial effects on the body:

1. Antihypertensive (normalization of high blood pressure).
2. Antiarrhythmic (normalization of the heart rate).
3. Antianginal (elimination of manifestations of ischemia).

During the first days of treatment, vascular resistance to peripheral blood flow increases slightly. This is a consequence of the activation of alpha-adrenergic receptors. After 1-3 days, the indicators return to the original ones. Subsequently, the resistance from the vessels begins to decrease.

The antihypertensive effect of Concor is due to the fact that under the action of the drug:

• The minute volume of blood decreases;
• The activity of the renin-angiotensin system is suppressed;
• Stimulated by the central nervous system;
• Responsive sensitivity is restored when the pressure decreases.

Patients with hypertension notice the first improvement in their well-being within 2-5 days. A stable effect of treatment with Concor is achieved at least 1-2 months.

The drug also relieves arrhythmias, eliminating negative factors - tachycardia, arterial hypertension, and slowing down the spontaneous excitability of pacemakers. Signs of ischemia disappear due to a decrease in the amount of oxygen required by the myocardium for nutrition. This is due to a slowdown in heart contractions, an increase in the length of diastole, and stimulation of perfusion of the heart muscle.

Provided that therapeutic doses are taken, the drug causes a less noticeable effect on β1-adrenergic receptors than non-selective analogues. They are located in the skeletal muscles, smooth muscles of the peripheral arteries, pancreas. Also, during the treatment with Concor, there are no violations of carbohydrate metabolism, sodium does not linger in the body.

Instruction

Before taking Concor, you should carefully study the instructions, especially regarding the maximum dosages. Self-administration of the drug is unacceptable. It is dispensed from pharmacies only by prescription.

Ingestion

The drug is drunk 1 time in 24 hours with water. Concor can be taken whenever convenient, regardless of food. However, the drug should not be chewed or crushed into powder - only swallowed whole.

Arterial hypertension and stable angina

The standard dose for starting treatment with Concor is 5 mg. 1 time per day. In the absence of the desired effect, the dose can be increased, but up to a maximum of 20 mg.

CHF

Concor can be used to relieve symptoms of CHF only under the supervision of doctors. First you need to go through the titration phase, during which you should drink 1.25 mg. medication per day. If it is well tolerated, the dose can be gradually increased by 1.25 mg. with an interval of 2 weeks. The maximum daily dosage reaches 10 mg.

During the titration phase and subsequently, a temporary aggravation of the course of CHF, as well as the occurrence of bradycardia and hypotension, is possible. Then you should temporarily reduce the dosage of the drug or cancel it completely.

The course of treatment can be repeated after the normalization of the patient's condition.

Duration of treatment

The process of treatment with Concor takes a long time. To say more precisely about the timing of taking the pills can only be a doctor based on tests and a survey of a particular patient.

Impaired kidney or liver function

In most cases, with minor deviations in the functioning of the kidneys and liver, a change in the dosage of Concor is not required. However, with severe pathologies of these organs, no more than 10 mg of the drug can be taken per day.

Increasing the dosage should be carried out carefully and always under the supervision of a doctor.

Elderly patients

They can take Concor, guided by a typical treatment regimen from the instructions. People over 65 do not need to adjust the dosage.

Children and teenagers

The medicine is not recommended for people under 18 years of age. Studies on how Concor works on a developing organism have not been conducted. There are insufficient data to support the safety of treatment with this drug in minors.

Contraindications

Concor should not be taken by people who have the following contraindications:

• Hypersensitivity to bisoprolol or other components;
• Decompensated heart failure;
• Sinoatrial blockade;
• Cardiogenic shock;
• metabolic acidosis;
• Sick sinus syndrome;
• Severe hypotension;
• AV blockade 2 and 3 degrees;
• Pheochromocytoma;
• Severe bradycardia;
• Severe asthma or chronic lung disease with obstruction;
• Severe arterial blood flow disorders or Raynaud's syndrome;
• Minor age.

Use during pregnancy and lactation

A doctor allows a pregnant woman to be treated with Concor in the only case: if the expected benefit for her outweighs the dangers to the fetus or child.

The fact is that under the influence of a β-blocker, the blood supply to the placenta decreases. Lack of oxygen can adversely affect the development of the fetus.

If a pregnant woman takes Concor, then she should be observed by a doctor. If abnormalities are detected in the fetus, the drug should be immediately canceled, and the woman should be prescribed appropriate medical procedures.

Also, a woman who took Concor during pregnancy may have a child with hypoglycemia and bradycardia. Signs of these diseases are important to track in the first days of life.

Studies on the penetration of bisoprolol into breast milk have not been conducted. To prevent risks, a woman should stop the drug during lactation. Otherwise, she should transfer the newborn to formula milk.

Side effects

The instructions for the drug list a large number of side effects. In most cases, they appear only at an early stage of treatment, more often in patients with hypertension or angina pectoris. Then everything goes away on its own in a couple of weeks or earlier.

The most common adverse reactions to Concor are:

• Dizziness and headaches;
• severe fatigue;
• Asthenia, bradycardia (with HNS);
• Nausea with vomiting;
• Constipation and diarrhea.

Interaction with other drugs

The instructions for use also indicate an extensive list of drugs that are not recommended to be taken simultaneously with Concor. Such combinations may affect the efficacy and tolerability of bisoprolol. Therefore, you should inform your doctor about taking other medicines, including those available without a prescription.

Prohibited Combinations

When combined, it is possible to slow down the heart rate, reduce cardiac output and vasodilation. It is also impossible to abruptly cancel other antihypertensive drugs - otherwise the risk of "rebound" hypertension will increase.

Combinations that require caution

The antihypertensive effect of Concor can be enhanced by any other drugs with similar effects, as well as local beta-blockers (including eye drops for glaucoma) and MAO inhibitors (except MAO B). Such combinations create the risk of overdose.

Non-steroidal anti-inflammatory drugs and β-agonists, on the contrary, often suppress the antihypertensive effect of Concor. As a result, treatment is significantly delayed or becomes meaningless.

When combining Concor and medicines, through which general anesthesia is carried out, there is a danger of the onset of a cardiodepressive effect. It can provoke arterial hypotension.

Overdose

If the allowable dose of the drug is exceeded, the following symptoms most often occur (especially in the presence of CHN):

• AV block;
• hypoglycemia;
• a sharp drop in pressure;
• severe bradycardia;
• spasm in the bronchi;
• acute heart failure.

If these symptoms are detected, you need to stop taking Concor and consult a doctor for symptomatic treatment.

Shelf life and storage conditions

The medicine should be in a place hidden from children, where the temperature is maintained up to 30 ° C. The drug is valid for 5 years.

Analogues

Concor has a large number of analogues that have a similar effect on the body. These are the following drugs:

1. Lerkamen.
2. Amlodipine.
3. Norvask.
4. Coronal.
5. Bisoprolol.
6. Niperten.
7. Bisoprolol-Verte.
8. Carvedilol.
9. Atenolol.

According to reviews, many patients resort to Concor analogues because of their lower price. The most economical is Bisoprolol-Verte. It costs about 60 rubles per pack, or 5-6 times cheaper than Concor.

According to patients, Concor stops the symptoms of hypertension, but the effect of the drug does not last long. Refusal of pills soon leads to an increase in pressure. Of the positive qualities of the drug, patients indicate the absence of pronounced adverse reactions.

Galina: I used to try many pills, droppers, injections, but the pressure decreased only temporarily. Almost always it was at the level of 220 x 120. I went to another doctor, and he prescribed Concor. I have been taking these pills in the morning on an empty stomach for more than six months. I feel good. Basically, the pressure is 130 x 70, but if I try to temporarily not take pills, it soon rises to 160. I think, first you need to try to reduce the dose.

Hope: I am only 37, and I am already a hypertensive patient with experience. Of all the things I've taken, Concor suits me better so far. The pressure dropped to 120/70 plus I began to breathe normally, and before, there was often not enough oxygen. In addition to everything, at night I was drawn behind the sternum in the region of the heart. Concor also relieved these pains. I can finally sleep on my left side, I have long dreamed about it.

Concor Cor, the instructions for use of which states that this is one of the best drugs that is used in the fight against cardiovascular diseases, is famous for its low price and fast action, and helps to reduce blood pressure in a timely manner. The active substance of the drug is a group of beta-blockers that can quickly block beta-adrenergic receptors in the heart. Patients with disorders in the work of the cardiovascular system often prefer the drug Concor Cor.

Instructions for use describe the pharmacokinetics of the drug. According to the instructions, the drug is able to have both antianginal and antiarrhythmic effects. If the drug is taken by a patient suffering from hypertension, the result is noticeable after 4-5 days, a permanent improvement in the condition occurs after 30-60 days.

The main advantage of the mechanism of action of the drug Concor Cor, instructions for use for which comes with the tablets, is its ability to suppress the transmission of a nerve impulse, which is located in adrenoreceptors.

Biosporol, which is one of the main components of the substances contained in the preparation, is able to quickly reduce the minute volume of blood.

With regular use of the drug, significant improvements occur after the first two months of use., and the visible result is noticeable after the first five days of application. Blood pressure decreases steadily, Concor Cor does not cause discomfort in other internal organs.

The second significant advantage of the drug is a decrease in myocardial oxygen demand, due to which a contraction occurs. The period of diastole gradually increases. This effect in medicine is called antianginal.

The electrical conductivity of the myocardium slows down, the electrical impulses, the processes of formation of which occur in the sinus node and the incomplete blocking of the sympathetic division of the nervous system, are factors in the formation of antiarrhythmic effects.

Concor Cor - what helps, release forms

Concor Cor - what the drug helps with and what it is produced in, we'll talk further. Concor Cor is available only in tablets. It is also worth noting the original design - the tablets are shaped like a heart. They are covered with a white shell and there is a risk on both sides, with which it is easy to break the tablet into two parts.

The number of pieces in one package can be from 10 to 30, respectively, and the price will vary. According to these data, the cost of the minimum package of the drug is no more than 170 rubles. The tablets are packed in special foil blisters.

Unfortunately, due to the existing contraindications, it is impossible to purchase Concor Cor without a doctor's prescription.

What does the drug help? Patients suffering from various cardiac diseases, including arrhythmia, angina pectoris, arterial hypertension, acute or mild heart failure and other heart diseases, are prescribed Concor. Instructions for use, at what pressure to take and other information should be explained to you in detail by your doctor.

The drug should be taken strictly under the supervision of a doctor, the drug Concor should be taken, the dosage should be carefully observed. Otherwise, self-medication will lead to life-threatening consequences.

The maximum daily dose used should not exceed 10 mg. If the manifestations of heart failure become more frequent, you should urgently reduce the dose and consult a doctor for its subsequent adjustment.

The medication is taken for a long time (from two weeks to several months). Abrupt withdrawal of use can lead to serious problems, so the withdrawal of the drug occurs by gradually reducing the dosage.

The list of contraindications to the drug is quite large, which once again emphasizes the need to control its intake with the attending physician. Before starting treatment, tests are required, thanks to which you can assess the general degree of the patient's condition and find out about intolerance to any components of the drug.

Contraindications:

• Individual intolerance to the components of the drug.
• Prinzmetal's angina.
• The drug must not be used by minors under the age of 18.
• With bronchial asthma and any diseases of the upper and lower respiratory tract, it is extremely forbidden to use the drug.
• metabolic acidosis.
• Pheochromocytoma.
• Bradycardia in any form of manifestation.
• Shock conditions of any severity.
• Severe AV block.
• Cardiac unworthiness in a decompensated form.
• Some forms of heart failure.
• Collapse.

Tablets Concor Cor - instructions for use and comparison of drugs Concor and Concor Cor

Concor Cor tablets, instructions for use of which are always in the pharmacy, must be taken orally without chewing. Drink plenty of water.

It is taken once a day, in the morning. Food intake does not depend on application.

The attending physician will prescribe the dosage for each patient individually. In this case, the general condition of the patient and the clinical indications will be taken into account.

For the treatment of angina pectoris or arterial hypertension, the dosage is selected taking into account the indications of the heart rate. The course should start from 4 mg per day. If the need arises, the dosage can be increased to 9 mg, it is better not to exceed more than 15 mg.

It is better then to replace them with Concor tablets, the instructions of which contain all the information about the daily dosage.

Chronic heart failure is treated in the classical way. Therapy includes complex treatment, it consists of the inclusion of angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor antagonists, diuretics, beta-blockers, cardiac glycosides. It is best to prescribe a dosage of 1.23 mg at the initial dose. After that, the adjustment will depend on the individual tolerance of bisoprolol. The dose is increased over time, once every two weeks by 1.25 mg. The largest dosage is 10 mg.

The calculation of the dosage is prescribed by the doctor, while it is necessary to control the heart rate, blood pressure. If an exacerbation occurs, but you need to reduce the dose.

An increase in blood pressure during pregnancy is quite common and is a dangerous threat, because there is a violation of blood circulation, and premature birth can occur.

However, if necessary, the doctor may prescribe Concor Cor tablets. Instructions for use do not recommend taking this drug by pregnant women, because they have not yet fully studied how it affects the development of the fetus. In addition, there is a decrease in blood flow saturation. All this leads to a lack of blood supply to the placenta. Therefore, the drug is prescribed only, as a last resort, an increase in blood pressure. In addition, a woman must be under the close attention of medical personnel who will assess the general condition and development of the fetus.

Approximately two days before the scheduled date of delivery, the use of the drug should be stopped. The dosage and course of treatment is determined by the doctor who observes the woman during pregnancy.

During breastfeeding, you should stop taking the drug. If there is a need to take the drug during lactation, breastfeeding should be stopped for a while.

Consider how Concor Cor tablets and Concor tablets differ, their instructions are almost the same, but there is still a difference. These two drugs in their composition have the active substance Bisoprolol. They are complete analogs. They differ only in the dosage of the active substance. Release "Concor" in tablets that contain 5 or 10 mg of the active substance, and "Concor Cor" has only 2.5 mg of the substance. They also have external differences. "Concor Cor" is produced in white, and "Concor" is painted in yellow.

Concor - side effects and interactions with other drugs

Concor, the side effects of which occur infrequently, can be manifested by the following symptoms: weak heartbeat, slight drops in blood pressure, nausea, and worsening of the general condition:

• In the circulatory system, side effects are: bradycardia (decrease in heart rate), numbness of the extremities, hypotension.
• In the nervous system: dizziness, depression, insomnia, bad dreams, hallucinations.
• Respiratory system: exacerbation of bronchial asthma.
• In the musculoskeletal system: convulsions, muscle weakness.
• Sense organs: hearing impairment, purulent eye diseases.
• Digestion: nausea, vomiting, diarrhea, increased levels of AST and ALT in the bloodstream, diarrhea.
• Genitourinary system: violation or lack of potency in men.
• Skin: alopecia, allergy (appearance of itching, rash, redness of the skin).

In case of an overdose of Concor, side effects may manifest as the following symptoms:

• Decrease in heart rate.
• Severe drop in blood pressure.
• Bronchospasms.
• The development of hypoglycemia (decrease in the content of glucose in the bloodstream).
• AHF (acute heart failure).

If you experience any of the above side effects, then you should immediately stop the use of this drug, and treat according to symptoms.

If bradycardia develops, then appoint / in Atropine. With hypotension, intravenous vasopressor drugs and plasma-substituting solutions are prescribed. Exacerbation of CHF is stopped by the introduction of diuretics and vasodilators. Hypoglycemia is treated with a glucose solution, and bronchospasm is treated with aminophylline.

The patient should tell the doctor if he is currently taking other drugs.

• Antiarrhythmic drugs, since the active substance "Concor" can lower the conductivity and contractility of the heart.
• Antihypertensive drugs. Their simultaneous use can cause bradycardia and a decrease in cardiac output.
• cardiac glycosides. This is dangerous because the pulse time may increase and the heart rate may decrease.

Despite the effective effect on the body, many patients are looking for analogues of this drug. An analogue is a drug that has the same pharmacological group, but differs in composition (a different active substance).

Here is some list of analogues of "Concora Cor":

1. "Bikard"
2. "Bisocard"
3. "Bisoprolol-lugal"
4. "Cardiosafe"
5. "Coronal"
6. "Atenolol"
7. "Corvitol"

Currently, there is an analogue in Russia - "Biprol". Most often, the cost of an analogue is always several times lower. For example, the cost of the drug Biprol is 150 rubles and it is much cheaper compared to the drug Concor 2.5 mg, the instructions for use of which will always help determine the dosage.

The cost of the drug varies from 310 to 360 rubles per package (5 mg No. 50). A package of 50 tablets (10 mg) will come out from 460 to 580 rubles on average.

Subject to all the rules for the use and prescription of the dosage, it is effective for the treatment of arrhythmias, hypertension, and chronic heart failure.

Concor is an antihypertensive drug that contains bisoprolol. Belongs to the group of beta-receptor blockers (short-acting beta-blockers).

Concor reduces the effect of the hormonal adrenaline on the human heart and therefore helps in the treatment of cardiovascular diseases: hypertension, tachycardia, heart failure and angina pectoris. The drug is able to normalize and restore pressure indicators. In the pharmacological classification of ATC, the drug is designated by the code C07AB07.

Concor 5 mg

Description of the mechanism of action of the drug

When stressed, the body releases the hormones adrenaline and norepinephrine. They cause an increased readiness to flee or fight. In the heart, both substances bind to beta-1 receptors. When these receptors are activated by messenger substances, the heart beats harder and faster, and blood pressure rises.

Bisoprolol belongs to the group of beta-blockers. It is "cardioselective" because it acts exclusively on the beta-1 receptors of the heart. Bisoprolol displaces adrenaline and norepinephrine at the receptors of the heart and thus inhibits their action. The number of heart contractions and the speed of circulating blood decrease, blood pressure drops significantly.

Pharmacodynamics of the drug "Concor"

Attention! The drug slows down the transmission of electrical impulses in the conduction system of the heart. It calms the heart muscle during severe stress.

Indications for the use of Concor

Bisoprolol is used in the treatment of hypertension that does not have an organic cause (essential hypertension) and cardiovascular disease. Bisoprolol is used for heart conditions that are associated with an insufficient supply of oxygen to the heart muscle (myocardial insufficiency).

In case of circulatory disorders of the coronary arteries (ischemic heart disease) and angina pectoris, bisoprolol is used. A more rare use of bisoprolol is maintenance therapy for anemia.

Patients with severe hypertension are often treated with various substances. In addition to bisoprolol, diuretics, antihypertensive agents (calcium channel blockers, ACE inhibitors) or vasodilators (digidralazine, prazosin) are used.

In myocardial insufficiency, the drug is combined with ACE inhibitors, diuretics and cardiac glycosides. In a certain proportion, they enhance the main therapeutic effect of Concor.

Alternative indications for the use of concor

Beta-blockers are used (albeit without official permission) for migraine, thyrotoxicosis and as a preventive measure for varicose veins of the lower extremities.

Concor tablets: instructions for use

Beta-blockers are usually given as salt (intravenous) or coated tablets (oral).

Concor is available as a combination drug with a diuretic (hydrochlorothiazide). Many patients suffer from an accumulation of water in the body (edema), which can be treated with medication. Edema disappears if you drink a diuretic.

At what pressure and how to take Concor?

The cardiologist determines individually the form of administration and dosage of the beta-blocker in each case. The dose depends on the etiology and severity of the disease. The doctor starts with a small dose and slowly increases. In adult women and men, start with 5 mg once daily (morning or evening). The active substance of Concor is excreted from the body for a long time, so the dose should not be raised above 20 mg per day.

Concor 10 mg

The duration of treatment is determined by the attending physician. In some cases, the drug is prescribed for a month as an adjuvant therapy for uncomplicated conditions (after surgery). For more information about the duration of treatment for various conditions, see the package leaflet.

Important! Concor is available by prescription only. The doctor prescribes the prescription. Concor should not be used without a doctor's prescription to lower blood pressure.

Analogues of the drug "concor"

In the CIS countries, there are many substitutes for concor:

• Bisoprolol vertex (a cheap analogue from a Russian manufacturer).
• Niperten.
• Aritel.
• Bisoprolol-teva.
• Concor nycomed.

Important! The shelf life (shelf life) of the package with the drug does not exceed 5 years.

Side effects

Adverse reactions may not occur in everyone. The type and frequency of side effects vary depending on the form of release of Concor (tablet, injection, ointment) or daily dosage.

Common side effects of concor:

• Increased fatigue.
• Dizziness.
• Migraine.
• Depression.
• Strong nightmares.
• Vivid dreams.
• Insomnia.
• Rave.
• Psychophysiological discomfort.
• Hyperhidrosis of the extremities.
• Reduced BP.
• Increased weakness of the heart muscle with the appearance of edema and difficulty breathing.
• Strengthening of local circulatory disorders (Reye's syndrome).
• Loss of appetite.
• Nausea.
• Constipation.
• Diarrhea.
• Pain in the epigastrium.
• Convulsions in the gastrointestinal tract.
• Atony.
• Muscle spasms.
• Allergic skin reactions.
• Sweating.
• lipid metabolism disorders.

Unusual side effects of concor:

• Blurred vision.
• Conjunctivitis.
• Dry eyes (take into account when wearing contact lenses).

Very rare side effects of taking Concor:

• Inflammation of the joints (one or more).
• Violation of libido (impotence or partial problems with potency).
• Erectile dysfunction.
• Increase in transaminases (GOT, GPT) in the blood.
• Inflammation of the liver.
• Alopecia.
• Formation of psoriasis.
• Exacerbation of psoriasis.
• Atrial fibrillation.
• Panic attack.
• Cough.
• Hair loss.
• Hearing loss.
• Noise in ears.
• Increase in body weight.
• Mood swings.
• Hay fever.
• Increased erection.
• Atrial fibrillation.
• Increased susceptibility to allergic reactions.

Side effects of unknown frequency when taking Concor:

• Prediabetes.
• Worsening of diabetes mellitus (paroxysmal hypoglycemia).
• Coma.
• Damage to the thyroid gland.

If you quickly stop drinking Concor, the pressure in the arteries can jump sharply (rebound syndrome). It is necessary to correctly reduce the dosage of the drug in order to avoid the adverse effects of the withdrawal syndrome. The patient should consult with the doctor how best to stop using concor. If you skip taking Concor, there may be adverse effects in the form of an increase in blood pressure.

Prolonged fasting and heavy physical exertion when taken with Concor lead to severe hypoglycemia. The patient may appear frightened and tremors are common.

Concor increases the body's sensitivity to allergens. Serious hypersensitivity reactions are possible in this context.

Contraindications to the use of the drug

The use of Concor is contraindicated in bronchial asthma, obstructive pulmonary disease, bradycardia, low blood pressure, advanced vascular disease and metabolic acidosis. Patients treated with monoamine oxidase inhibitors (MAOIs) should not take a beta-blocker. The same applies to patients with pheochromocytoma, a predominantly benign tumor of the adrenal glands.

Allergy or hypersensitivity to a beta-blocker or other components of the drug should be ruled out before starting therapy.

Exercise caution when combining Concor with other central antihypertensive drugs (clonidine), calcium channel antagonists (amlodipine) and drugs used for cardiac arrhythmias (lidocaine, amiodarone).

During pregnancy (especially in the first trimester), before starting therapy, carry out a risk-benefit assessment, since Concor may affect blood flow to the placenta and fetal development. Careful monitoring of the blood flow of the uterus and placenta should be carried out by a gynecologist if Concor is taken. Also, consider other treatment options.

In elderly patients, the dosage of Concor should be as low as possible. The drug is strictly contraindicated for children.

Severe hypotension may occur if concor is consumed and alcoholic beverages are taken. In this case, every minute is decisive for the poisoned patient. It is urgent to take the patient to the hospital or call an ambulance.

The dose of Concor should be initially low and increased in a controlled manner as needed. If the patient wants to stop taking bisoprolol, it is necessary to gradually reduce the dose over a long period of time. Abrupt withdrawal causes dangerous jumps in blood pressure ("rebound effect").

Interaction of Concor with other drugs

The interaction varies depending on the dosage form of the drug (tablets, injections, ointments).

The hypotensive effect of Concor can be enhanced by the simultaneous administration of additional substances to lower blood pressure: ACE inhibitors (prestarium), vasodilators (vasodilators), diuretics or calcium channel blockers. Concor is compatible with adenosine.

Do not combine sleeping pills (barbiturates), antipsychotics, H1 antihistamines, anesthetics, tricyclic antidepressants or alcohol with Concor. An excessive decrease in blood pressure can lead to the development of weakness of the heart muscle.

Calcium channel blockers (verapamil or diltiazem) lead to a decrease in cardiac output (cardiodepressive effect). Decreased blood pressure, slow heart rate, arrhythmia, heart failure - the result of sharing with concor. Intravenous administration of these substances should be avoided except in rare cases. Verapamil should not be given by vein until 48 hours after stopping the drug.

Special substances against high blood pressure (reserpine, dopegit, guanethidine, guanfacine, cardiac glycosides or clonidine) cause a stronger decrease in heart rate and cardiac conduction delay. days after discontinuation of clonidine.

Clonidine

Substances that increase blood pressure (inhibitors of the norepinephrine, adrenaline or MAO transporters, except for MAO-B inhibitors) weaken the effect of lowering blood pressure. The opposite effect may occur - an excessive increase in pressure in the arteries.

Co-administration of hypoglycemic agents (insulin or oral antidiabetic agents) with Concor may exacerbate hypoglycemia. Symptoms of hypoglycemia, especially palpitations and tremors, can be treated with medication. Therefore, diabetics need regular monitoring of blood glucose levels during treatment with Concor.

Alpha-sympathomimetics (including tacrine), when administered concomitantly with Concor, may prolong conduction time in the atrioventricular node of the heart and cause severe arrhythmias.

If digoxin is used to strengthen the strength of the heart, the excretion of this substance in the blood is delayed. Therefore, medical supervision and control of the amount of digoxin in the blood is necessary. If necessary, a dose reduction of cardiac glycoside is required.

When combined with the antimalarial mefloquine, the risk of developing severe sinus bradycardia increases.

Antirheumatic and analgesic drugs of the latest generation (indomethacin or ibuprofen) slightly weaken the hypotensive effect of bisoprolol, so their compatibility is questionable. Modern anti-tuberculosis drugs (rifampicin) tend to reduce the effectiveness of Concor.

Rifampicin

Gastric acid inhibitors (antacids): cimetidine or ranitidine - lead to an increase in the effect of lowering blood pressure.

Warnings and Precautions While Using Concor

Therapy with the drug should not be stopped suddenly, it is necessary to reduce the dose within 5-7 days in order to avoid the development of rebound syndrome.

In the early stages of treatment, the patient should be supervised by a doctor. First of all, the doctor should check blood pressure, heartbeat, conduction disturbances in the heart and possible worsening of myocardial insufficiency.

During treatment with the drug, the patient should regularly check the pressure. Especially at the beginning of treatment or when changing the dosage, Concor can lead to a decrease in working capacity. As a result, driving a car, motorcycle and working without reliable insurance is dangerous.

The drug reduces the formation of tear fluid, which may affect the wearing of contact lenses. Sometimes concor causes allergic reactions. If the patient notices signs of an allergic reaction, the doctor or pharmacist should be informed immediately.

Anaphylactic shock due to concor

Advice! Concor should not be combined with folk remedies. The planning of the drug treatment regimen should be carried out by a cardiologist.

Trade name of the drug: Concor ®

International non-proprietary name:

bisoprolol

Dosage form:

film-coated tablets

Compound:

1 film-coated tablet, 5 mg contains:
Nucleus
Active substance: bisoprolol fumarate 2:1 (bisoprolol hemifumarate) - 5 mg
Excipients:
shell
Iron dye yellow oxide (E 172), dimethicone 100, macrogol 400, titanium dioxide (E 171), hypromellose 2910/15.

1 film-coated tablet, 10 mg contains:
Nucleus
Active substance: bisoprolol fumarate 2:1 (bisoprolol hemifumarate) - 10 mg
Excipients: anhydrous colloidal silicon dioxide, magnesium stearate, crospovidone, microcrystalline cellulose, corn starch, anhydrous calcium hydrogen phosphate.
shell
Iron dye red oxide (E 172), iron dye yellow oxide (E 172), dimethicone 100, macrogol 400, titanium dioxide (E 171), hypromellose 2910/15.

Description
Film-coated tablets, 5 mg:
Pale yellow, heart-shaped, biconvex, film-coated tablets scored on both sides.
Film-coated tablets, 10 mg:
Light orange, heart-shaped, biconvex film-coated tablets, scored on both sides.

Pharmacotherapeutic group:

beta 1 - selective blocker

ATX code: C07AB07

Pharmacotherapeutic properties

Pharmacodynamics
Selective beta 1 - blocker, without its own sympathomimetic activity, does not have a membrane stabilizing effect. Reduces plasma renin activity, reduces myocardial oxygen demand, reduces heart rate (HR) (at rest and during exercise). It has antihypertensive, antiarrhythmic and antianginal effects. Blocking in low doses beta 1-adrenergic receptors of the heart, it reduces the formation of cAMP from ATP stimulated by catecholamines, reduces the intracellular current of calcium ions, has a negative chrono-, dromo-, batmo- and inotropic effect (inhibits conduction and excitability, slows down atrioventricular conduction).
With an increase in the dose above the therapeutic one, it has a beta 2 -adrenergic blocking effect.
The total peripheral vascular resistance at the beginning of the drug, in the first 24 hours, slightly increases (as a result of a reciprocal increase in the activity of alpha-adrenergic receptors), which after 1-3 days returns to the original, and decreases with long-term administration.
The hypotensive effect is associated with a decrease in the minute volume of blood, sympathetic stimulation of peripheral vessels, a decrease in the activity of the renin-angiotensin system (it is of great importance for patients with initial renin hypersecretion), restoration of sensitivity in response to a decrease in blood pressure (BP) and an effect on the central nervous system ( CNS). With arterial hypertension, the effect occurs after 2-5 days, stable action - after 1-2 months.
The antianginal effect is due to a decrease in myocardial oxygen demand as a result of a decrease in heart rate, a slight decrease in contractility, a prolongation of diastole, and an improvement in myocardial perfusion. The antiarrhythmic effect is due to the elimination of arrhythmogenic factors (tachycardia, increased activity of the sympathetic nervous system, increased cAMP content, arterial hypertension), a decrease in the rate of spontaneous excitation of sinus and ectopic pacemakers and a slowdown in atrioventricular (AV) conduction (mainly in antegrade and, to a lesser extent, in retrograde directions through the atrioventricular node) and along additional pathways.
When used in medium therapeutic doses, unlike non-selective beta-blockers, it has a less pronounced effect on organs containing beta 2-adrenergic receptors (pancreas, skeletal muscles, smooth muscles of peripheral arteries, bronchi and uterus) and on carbohydrate metabolism, does not cause retention of sodium ions (Na+) in the body.

Pharmacokinetics
Suction. Bisoprolol is almost completely (>90%) absorbed from the gastrointestinal tract. Its bioavailability due to negligible "first pass" metabolism through the liver (at the level of about 10%-15%) is about 85-90% after oral administration. Eating does not affect bioavailability. Bisoprolol exhibits linear kinetics, with plasma concentrations being proportional to the administered dose over the dose range of 5 to 20 mg. The maximum plasma concentration is reached after 2-3 hours.
Distribution. Bisoprolol is distributed quite widely. The volume of distribution is 3.5 l/kg. Communication with proteins of a blood plasma reaches approximately 35%; capture by blood cells is not observed.
Metabolism. Metabolized by the oxidative pathway without subsequent conjugation. All metabolites are highly polar and are excreted by the kidneys. The main metabolites found in blood plasma and urine do not show pharmacological activity. Data obtained from experiments with human liver microsomes in vitro show that bisoprolol is metabolized primarily by CYP3A4 (about 95%), and CYP2D6 plays only a small role.
Withdrawal. The clearance of bisoprolol is determined by the balance between its excretion through the kidneys in the form of an unchanged substance (about 50%) and oxidation in the liver (about 50%) to metabolites, which are then also excreted by the kidneys. The total clearance is 15.6 ± 3.2 l / h, and the renal clearance is 9.6 ± 1.6 l / h. The half-life is 10-12 hours.

Indications for use

arterial hypertension

ischemic heart disease: prevention of angina attacks.

chronic heart failure Contraindications
The drug Concor ® should not be used to treat patients with the following conditions:

hypersensitivity to bisoprolol or to any of the components of the drug (see section "Composition") and to other beta-blockers;

acute heart failure, chronic heart failure in the stage of decompensation;

shock caused by impaired cardiac function (cardiogenic shock), collapse;

atrioventricular block II and III degree, without a pacemaker;

sick sinus syndrome;

sinoatrial blockade;

severe bradycardia (heart rate less than 50 bpm);

a pronounced decrease in blood pressure (systolic blood pressure less than 90 mm Hg. Art.);

severe forms of bronchial asthma and chronic obstructive pulmonary disease in history;

late stages of peripheral circulatory disorders, Raynaud's disease;

pheochromocytoma (without the simultaneous use of alpha-blockers);

metabolic acidosis;

simultaneous administration of monoamine oxidase (MAO) inhibitors, with the exception of MAO-B;

age up to 18 years (efficacy and safety have not been established).
With caution: liver failure, chronic renal failure, Prinzmetal's angina; myasthenia gravis, thyrotoxicosis, diabetes mellitus, atrioventricular block I degree, depression (including history), psoriasis, old age. Use during pregnancy and lactation
During pregnancy, Concor should only be recommended if the benefit to the mother outweighs the risk of side effects in the fetus.
As a rule, beta-blockers reduce blood flow in the placenta and may affect the development of the fetus. Blood flow in the placenta and uterus should be carefully monitored, as well as the growth and development of the unborn child, and in case of dangerous manifestations in relation to pregnancy or the fetus, alternative therapeutic measures should be taken. The newborn should be carefully examined after delivery. In the first three days of life, symptoms of low blood glucose and heart rate may occur. There are no data on the excretion of bisoprolol into breast milk or the safety of exposure to bisoprolol in infants. Therefore, taking Concor is not recommended for women during breastfeeding. Dosage and administration
The tablets should be taken with a small amount of liquid in the morning before, during or after breakfast. Tablets should not be chewed or crushed into powder. Treatment of arterial hypertension and angina pectoris
In all cases, the regimen and dosage is selected by the doctor for each patient individually, in particular, taking into account the heart rate and the patient's condition.
The usual starting dose is 5 mg (1 tablet Concor ® 5 mg) once a day. If necessary, the dosage can be increased to 10 mg once a day.
In the treatment of arterial hypertension and angina pectoris, the maximum recommended dose is 20 mg Concor ® once a day. Treatment of chronic heart failure
The beginning of the treatment of chronic heart failure with Concor ® requires a special titration phase and regular medical supervision.
The preconditions for treatment with Concor ® are as follows:

chronic heart failure without signs of exacerbation in the previous six weeks,

practically unchanged basic therapy in the previous two weeks,

treatment with optimal doses of ACE inhibitors (or other vasodilators in case of intolerance to ACE inhibitors), diuretics and, optionally, cardiac glycosides.
Treatment of chronic heart failure with Concor ® begins in accordance with the following titration scheme. This may require individual adaptation depending on how well the patient tolerates the prescribed dose, i.e. the dose can be increased only if the previous dose was well tolerated.

* To ensure the above dosing regimen at subsequent stages of treatment, it is recommended to use the drug Concor ® .

The maximum recommended dose in the treatment of chronic heart failure is 10 mg of Concor ® 1 time per day. Patients are advised to take the dose of the drug selected by the doctor if no adverse reactions occur.
After starting treatment with the drug at a dose of 1.25 mg (1/2 tablet of Concor KOR), the patient should be observed for about 4 hours (control of heart rate, blood pressure, conduction disturbances, signs of worsening heart failure).
During the titration phase or after it, a temporary worsening of the course of heart failure, fluid retention in the body, arterial hypotension or bradycardia may occur. In this case, it is recommended, first of all, to pay attention to the selection of the dosage of concomitant basic therapy (optimize the dose of diuretic and / or ACE inhibitor) before reducing the dosage of Concor ® . Treatment with Concor ® should be interrupted only if absolutely necessary.
After stabilization of the patient's condition, re-titration should be carried out, or treatment should be continued. Duration of treatment for all indications
Treatment with Concor ® is usually a long-term therapy. If necessary, treatment can be interrupted and resumed subject to certain rules.
Treatment should not be interrupted suddenly, especially in patients with ischemic heart disease. If it is necessary to stop treatment, then the dosage of the drug should be reduced gradually. Special patient groups
Impaired kidney or liver function:
Treatment of arterial hypertension or angina pectoris:

In case of impaired liver or kidney function, mild or moderate, usually does not require dose adjustment.

With severe renal dysfunction (creatinine clearance less than 20 ml / min.) And in patients with severe liver disease, the maximum daily dose is 10 mg.
Elderly patients:
Dose adjustment is not required. Side effect
The frequency of the adverse reactions listed below was determined according to the following:
-very often: ≥1/10;
- often: >1/100.<1/10;
- infrequently:> 1/1000.<1/100:
-rarely: >1/10 OOO.<1/1000:
-very rarely:<1/10 ООО. включая отдельные сообщения. The cardiovascular system
Very often: decrease in heart rate (bradycardia, especially in patients with chronic heart failure); often: arterial hypotension (especially in patients with chronic heart failure), manifestation of angiospasm (increased peripheral circulatory disorders, feeling of coldness in the extremities (paresthesia); infrequently: impaired atrioventricular conduction, orthostatic hypotension, decompensation of heart failure with the development of peripheral edema. Nervous system
At the beginning of the course of treatment, disorders of the central nervous system may temporarily appear, infrequently: dizziness, headache, asthenia, increased fatigue, sleep disturbances. as well as mental disorders (infrequently - depression, rarely hallucinations, nightmares, convulsions). Usually these phenomena are mild and disappear, as a rule, within 1-2 weeks after the start of treatment. organs of vision
Rare: blurred vision, decreased tearing (should be taken into account when wearing contact lenses): very rarely: conjunctivitis. Respiratory system
Rare: allergic rhinitis. Uncommon: bronchospasm in patients with bronchial asthma or obstructive airways disease. Gastrointestinal tract
Often: nausea, vomiting, diarrhea, constipation, dryness of the oral mucosa; rarely: hepatitis. Musculoskeletal system
Infrequently: muscle weakness, cramps in the calf muscles, arthralgia. allergic reactions
Rare: hypersensitivity reactions such as pruritus. skin redness, sweating, rash. Very rare: alopecia. Beta-blockers can exacerbate psoriasis. genitourinary system
Very rare: erectile dysfunction. Laboratory indicators
Rarely: increased levels of liver enzymes in the blood (ACT, ALT), increased levels of triglycerides in the blood. In some cases: thrombocytopenia, agranulocytosis. Overdose
Symptoms: arrhythmia, ventricular extrasystole, severe bradycardia, atrioventricular block. pronounced decrease in blood pressure, acute heart failure, hypoglycemia, acrocyanosis, difficulty breathing, bronchospasm, dizziness, fainting, convulsions.
Treatment: gastric lavage and the appointment of adsorbing drugs; symptomatic therapy: with developed atrioventricular blockade - intravenous administration of 1-2 mg of atropine, epinephrine or setting up a temporary pacemaker; with ventricular extrasystole - lidocaine (class IA drugs are not used); with a pronounced decrease in blood pressure - the patient should be in the Trendelenburg position; if there are no signs of pulmonary edema - plasma-substituting solutions intravenously, if ineffective - the introduction of epinephrine, dopamine, dobutamine (to maintain the chronotropic and inotropic action and eliminate a pronounced decrease in blood pressure); in heart failure - cardiac glycosides, diuretics, glucagon; with convulsions - intravenous diazepam; with bronchospasm - beta 2 - adrenostimulants inhalation. Interaction with other drugs
The effectiveness and tolerability of drugs may be affected by the simultaneous use of other drugs. This interaction can also occur when two drugs are taken after a short period of time. The doctor must be informed that you are taking other medicines, even if you are taking them without a prescription.
Allergens used for immunotherapy or allergen extracts for skin tests increase the risk of severe systemic allergic reactions or anaphylaxis in patients receiving bisoprolol.
Iodine-containing radiopaque diagnostic agents for intravenous administration increase the risk of developing anaphylactic reactions.
Phenytoin when administered intravenously, drugs for inhalation general anesthesia (derivatives of hydrocarbons) increase the severity of the cardiodepressive effect and the likelihood of lowering blood pressure.
The effectiveness of insulin and oral hypoglycemic drugs may change during treatment with bisoprolol (masks the symptoms of developing hypoglycemia: tachycardia, increased blood pressure).
The clearance of lidocaine and xanthines (except for diphylline) may decrease due to a possible increase in their plasma concentration, especially in patients with initially increased clearance of theophylline under the influence of smoking. Non-steroidal anti-inflammatory drugs, glucocorticosteroids and estrogens weaken the hypotensive effect of bisoprolol (Na + retention, blockade of prostaglandin synthesis by the kidneys).
Cardiac glycosides, methyldopa, reserpine and guanfacine, calcium channel blockers (verapamil, diltiazem), amiodarone and other antiarrhythmic drugs increase the risk of developing or worsening bradycardia, atrioventricular block, cardiac arrest and heart failure.
Nifedipine can lead to a significant decrease in blood pressure.
Diuretics, clonidine, sympatholytics, hydralazine and other antihypertensive drugs can lead to an excessive decrease in blood pressure.
The action of non-depolarizing muscle relaxants and the anticoagulant effect of coumarins during treatment with bisoprolol may be prolonged.
Tri- and tetracyclic antidepressants, antipsychotics (neuroleptics), ethanol, sedatives and hypnotics increase CNS depression. Simultaneous use with MAO inhibitors is not recommended due to a significant increase in the hypotensive effect. A break in treatment between taking MAO inhibitors and bisoprolol should be at least 14 days. Non-hydrogenated ergot alkaloids increase the risk of developing peripheral circulatory disorders.
Ergotamine increases the risk of developing peripheral circulatory disorders; sulfasalazine increases the concentration of bisoprolol in the blood plasma; rifampicin shortens the half-life. special instructions
Do not stop treatment abruptly and do not change the recommended dosage without first consulting your doctor, as this can lead to a temporary deterioration in the activity of the heart. Treatment should not be interrupted suddenly, especially in patients with ischemic heart disease. If discontinuation of treatment is necessary, the dosage should be reduced gradually.
Monitoring the condition of patients taking Concor ® should include measuring heart rate and blood pressure (at the beginning of treatment - daily, then 1 time in 3-4 months), ECG, determination of blood glucose in patients with diabetes mellitus (1 time in 4-5 months ). In elderly patients, it is recommended to monitor kidney function (1 time in 4-5 months). The patient should be taught how to calculate heart rate and should be instructed to consult a doctor if the heart rate is less than 50 bpm.
Before starting treatment, it is recommended to conduct a study of the function of external respiration in patients with a burdened bronchopulmonary history.
Patients using contact lenses should take into account that during treatment, a decrease in the production of lacrimal fluid is possible.
When used in patients with pheochromocytoma, there is a risk of developing paradoxical arterial hypertension (if effective alpha-blockade has not been previously achieved). In thyrotoxicosis, Concor ® may mask certain clinical signs of thyrotoxicosis (eg, tachycardia). Abrupt discontinuation of the drug in patients with thyrotoxicosis is contraindicated, as it can exacerbate symptoms. In diabetes mellitus, it can mask tachycardia caused by hypoglycemia. Unlike non-selective beta-blockers, it practically does not increase insulin-induced hypoglycemia and does not delay the restoration of blood glucose concentration to normal levels.
While taking clonidine, its reception can be stopped only a few days after Concor ® is canceled.
It is possible to increase the severity of the hypersensitivity reaction and the lack of effect from the usual doses of epinephrine against the background of an aggravated allergic history. If it is necessary to carry out planned surgical treatment, the drug should be discontinued 48 hours before general anesthesia. If the patient took the drug before surgery, he should choose a drug for general anesthesia with a minimally negative inotropic effect.
Reciprocal activation of the vagus nerve can be eliminated by intravenous atropine (1-2 mg).
Drugs that reduce catecholamine stores (including reserpine) can enhance the effect of beta-blockers, so patients taking such combinations of drugs should be under constant medical supervision to detect a pronounced decrease in blood pressure or bradycardia. Patients with bronchospastic diseases can be prescribed cardioselective blockers in case of intolerance and / or ineffectiveness of other antihypertensive drugs. If the dose of the drug is exceeded, there is a risk of developing bronchospasm.
If increasing bradycardia (heart rate less than 50 beats / min.), A pronounced decrease in blood pressure (systolic blood pressure below 100 mm Hg), atrioventricular blockade is detected in elderly patients, it is necessary to reduce the dose or stop treatment. It is recommended to stop therapy if depression develops.
You can not abruptly interrupt treatment because of the risk of developing severe arrhythmias and myocardial infarction. Cancellation of the drug is carried out gradually, reducing the dose for 2 weeks or more (reduce the dose by 25% in 3-4 days). It is necessary to cancel the drug before examining the content of catecholamines, normetanephrine and vanillinmandelic acid in the blood and urine; titers of antinuclear antibodies. Influence on the ability to drive a car and complex mechanisms
Bisoprolol does not affect the ability to drive a car in the study of patients suffering from diseases of the coronary vessels of the heart. However, due to individual reactions, the ability to drive a car or work with technically complex mechanisms may be impaired. Particular attention should be paid to this at the beginning of treatment, after changing the dose, and also with the simultaneous use of alcohol. Release form
Film-coated tablets, 5 and 10 mg.
10 tablets in a blister of aluminum foil and PVC, 3, 5 or 10 blisters, together with instructions for use, are placed in a cardboard box. Storage conditions
Store at a temperature not exceeding 30°C.
Keep out of the reach of children. Best before date
5 years. Do not use after the expiration date. Terms of dispensing from pharmacies
On prescription. Manufacturer
Merck KGaA, Germany Manufacturer's address:
Frankfurter Strasse 250 64293 Darmstadt, Germany
Frankfurterstrasse 250 64293 Darmstadt, Germany Presented in Russia and the CIS:
"Nycomed Austria GmbH", Austria: 119048 Moscow, st. Usacheva, d. 2, building 1

Cardiovascular diseases are widespread in the modern world. There are many reasons for this. With an increase in life expectancy, the number of vascular pathologies has increased. Stress, unfavorable environmental conditions, unbalanced nutrition exacerbate the situation. With consistently high pressure or jumps in blood pressure up, the attending physician may prescribe Concor tablets.

Before you start taking Concor, you should carefully study the instructions for use. Find out at what pressure you can drink pills without harming your health.

Hypertension has many faces. When prescribing a therapeutic course, many factors should be considered. A competent treatment program can only be created by a specialist on the basis of anamnesis and direct examination of the patient. Do not forget: self-treatment is dangerous!

How does the drug work?

Before you imagine the principle of the action of the drug on the body, you should understand the reasons for the increase in blood pressure.

This may be a spasm of the arteries or a decrease in their elasticity, tachycardia (high heart rate), renal pathologies, heredity, genetic predisposition and a number of other factors.

With an increase in pressure or an increase in heart rate, adrenaline is released into the blood. The vessels narrow, the volume of the bronchi expands, the flow of air into the lungs increases, the metabolic process accelerates. Adrenaline provides effective assistance to the body in critical situations, but not during illness.

Concor tablets help to stop unpleasant symptoms.

A selective beta-blocker (namely, Concor belongs to this group of drugs) limits the effect of adrenaline on cardiac activity and nerve endings susceptible to it.

As a result, the heartbeat slows down and the coronary arteries (the arteries that carry blood to the heart) dilate, resulting in a decrease in blood pressure. The mechanism that lowers blood pressure is based on a decrease in the volume of blood pushed by the heart into the circulatory system with each contraction.

Renin (a substance contained in the blood plasma responsible for regulating blood pressure) under the influence of the drug reduces its intensity, lowering the pressure.

The effect of the drug is well felt 4 hours after oral administration of the tablet. Concor is a long-acting drug (the active substance accumulates and has a beneficial effect on the cardiovascular system for a long time). A single daily dose guarantees a 24-hour therapeutic effect. Gently relieves pressure.

The use of the drug on an ongoing basis gives a stable positive result 15 days after the start of therapy.

Bisoprolol (the main active ingredient) is almost completely absorbed by the body, being absorbed by 90% from the gastrointestinal tract. The remaining 10% are metabolized. 3 hours after taking the drug in the blood plasma, the maximum concentration is formed.

All the ingredients that make up the drug are processed without entering into chemical reactions with other substances and without combining with them. Waste elements are excreted from the body with urine. The concentration of the substance is halved later - 10-12 hours after taking the medicine.

Composition and form of release

Concor is produced in the form of biconvex film-coated tablets of light yellow or orange color. The shape is heart-shaped. The presence of risks makes it easy to adjust the dosage and administration of the drug. Tablets of 5 mg or 10 mg are packed in blisters of 10 pieces. They go on sale packed in a cardboard box, 3-5 standards in each pack. Complete with official instructions.

Main active ingredient: bisoprolol. It has a directed extended drug effect. The maximum possible positive effect is achieved 3 hours after taking the Concor tablet.

The excipients that make up the drug contribute to the gradual release of the drug, optimally regulating the mechanism of pharmacodynamics.

The film shell consists of:

• titanium dioxide;
• hypromellose;
• dimethicone;
• macrogol and dyes.

The shell, gradually dissolving in the stomach, gradually releases the medicinal substance, contributing to a gradual long-term decrease in pressure.

Indications

Contraindications

The pharmaceutical industry produces drugs aimed at reducing blood pressure. Studies show that the higher the therapeutic efficacy of blood pressure lowering drugs, the more contraindications and side effects they have. Before taking the medicine, you should carefully study the list of prohibitions. Acceptance may be:

• heart failure in chronic and acute form;
• cardiogenic shock;
• violations of the sinus node;
• AV blockade 2 and 3 degrees, without a pacemaker;
• low blood pressure (below 100mmHg);
• slow heartbeat;
• bronchial pathology;
• circulatory disorders, accompanied by cooling of the limbs;
• tumors of the adrenal glands of a hormonal nature;
• violations of metabolic processes in the body;
• lactation period;
• hypersensitivity to individual ingredients of the drug.

Use with caution in patients suffering from:

• severe functional disorders of the liver;
• angina;
• some types of diabetes;
• thyroid disease with high levels of hormones in the blood;
• atrioventricular block I degree;
• scaly deprive (psoriasis);
• severe renal failure;
• congenital malformations of the heart or heart valve;
• restrictive cardiomyopathy;
• chronic heart failure in combination with myocardial infarction for 3 months;
• patients who are forced to follow a strict diet.

It happens that people with severe hypotension suffer from tachycardia. Can Concor be taken with low blood pressure? With a strong heartbeat against the background of pressure 90/60, Concor's intake is not excluded. Theoretically, taking the medicine in small doses is possible, but only a doctor can decide such issues.

Dosage

It is important to follow the rules for taking the drug. Tablets are taken once a day orally. They are not chewed, washed down with the necessary amount of water. Reception time - morning (can be on an empty stomach).

The dosage is determined by the attending physician, in accordance with clinical indications. In some cases, a gradual increase in dosage is practiced. The allowable amount is 20 mg per day.

The rate of adaptation of the patient to the drug depends on the individual tolerance of bisprolol. The doctor should monitor the following indicators:

• heart rate;
• arterial pressure.

With an exacerbation in the process of adaptation, the dosage should be reduced.

Cases of excessive lowering of pressure and slowing of the heart rate have been recorded. This is a reason to adjust the dose or completely cancel the drug until the patient's condition stabilizes.

Concor is a long-term drug that reduces blood pressure.

Patients with systemic lesions of the kidneys and liver, as well as the elderly, the daily dose is not more than 10 mg.

Overdose

An overdose can be fatal. The drug should be taken only on the recommendation and under the supervision of a physician.

In the case of excessive medication, the heartbeat may drop to a critical level. Perhaps a decrease in blood sugar below normal, a sharp decrease in blood pressure, bronchospasm, acute heart failure.

The therapeutic course is selected by the therapist on an individual basis.

Side effects

During the period of taking Concor tablets, unwanted side effects may occur.

The following negative manifestations are possible:

• dizziness and weakness;
• high fatigue;
• feeling of anxiety;
• confusion;
• short-term memory loss;
• insomnia;
• depression;
• arrhythmia;
• bradycardia;
• increased symptoms of cardiovascular insufficiency;
• deterioration of blood circulation;
• visual impairment;
• conjunctivitis;
• dry eyes;
• nausea and vomiting;
• abdominal pain and stool destabilization;
• distortion of taste sensations;
• liver dysfunction;
• bronchospasm;
• hives, etc.

Most of the discomfort goes away within a few days. In some cases, adaptation can take up to two weeks.

The use of Concor during pregnancy and lactation

The use of the drug during the period of bearing a child is possible in exceptional cases, when, according to the doctor, the expected therapeutic effect for the expectant mother outweighs the possible risk to the fetus (bisoprol is able to reduce the intensity of blood flow through the placenta).

During breastfeeding, the drug is contraindicated.

The nuances of the use of the drug

When starting a course of treatment for hypertension, it should be borne in mind that abrupt discontinuation of the drug is unacceptable. Dosage reduction should be implemented gradually under medical supervision.

When taking the drug, patients with bronchial pathology must simultaneously use drugs from the bronchodilator line. Concor provokes the development of sensitivity to allergens up to anaphylactic reactions.

If surgical treatment is planned using general anesthesia, the dosage of the drug should be gradually reduced in advance. Complete withdrawal of the drug should occur 2 days before surgery. The medical staff must be informed about the reception of Concor.

Concor is not always combined with other drugs. The patient is obliged to inform the attending physician about the intake of all drugs. The specialist will evaluate their possible interaction and give recommendations on the order of admission. A number of drugs can reduce or increase the therapeutic effect. Some drug combinations are undesirable.

All possible consequences of the interaction can only be assessed by a professional.

Precautions when storing the drug and expiration dates

Store at room conditions. The maximum allowable temperature is 30 °C. Keep away from children! Shelf life - 5 years from the date of manufacture. After the expiration date, do not use.

Sales through pharmacies

The drug is dispensed from pharmacies by prescription.

Price

The cost of the drug may vary, depending on the region and method of implementation. The recommended price in pharmacies is 173 rubles. (2.5 mg 30 pieces).

Analogues

The pharmaceutical industry produces a number of Concor analogues:

• Bisoprolol - from 47 rubles;
• Concor Kor - from 162 rubles;
• Coronal - from 114 rubles;
• Cordinorm - from 117 rubles.

At high pressure

Arterial hypertension is a chronic disease. It cannot be cured, but it can and should be controlled.

If you let the situation take its course, there is a high probability of developing coronary heart disease, strokes, kidney dysfunction, and a number of other pathologies. The sooner treatment for hypertension is started, the greater the chance of success.

Concor is an effective drug. With increased pressure, it has a positive effect on the body. A sharp drop in blood pressure can adversely affect human health. Concor gradually lowers and stabilizes blood pressure, relieves hypertensive crisis.

Concor has positive reviews:

Alla Vitaleva, 55 years old

I have been taking Concor blood pressure pills for several years now. The medicine calms the heartbeat well (I have tachycardia) and stabilizes the pressure (I suffer from high blood pressure, often rises to 160-180/100). I can not say that the adaptation was difficult for me. Concor suits me, the main thing is to listen to the doctor's advice.

Anastasia Gavrilenko, 45 years old

I have inherited high blood pressure. When the indicators rise to 200, everything is swimming before your eyes. Concor is "my" drug. The price is affordable. Heart pills evoke positive emotions. The effect of the drug is persistent.

Alexander Gaveryukin, 42 years old

I have hypertension. He took various drugs, but it did not work to reduce the pressure. Concor helped. The constant use of tablets had an impact on the decrease in performance. The pressure gradually began to decrease.

Cardiac treatment is based on various drugs, without which it is impossible to support the patient. One of the important medications is Concor.

High blood pressure affects people of both the elderly and middle age. The choice of the right medicine that alleviates the patient's condition depends on the therapeutic effect of the drug, its harmful and undesirable effects.

Composition and therapeutic effect

Concor is aimed at lowering blood pressure, lowering the increased heart rate and normalizing the heart rhythm. The main component of the drug is bisoprolol hemifumarate. The agent is supplemented with other elements, such as calcium hydrogen phosphate, starch, crospovidone, microcrystalline cellulose, magnesium stearate.

Concor reduces the necessary need for the myocardium of the heart to supply oxygen. Long-term use of the drug prevents angina pectoris and becomes a prophylactic against developing myocardial infarction.

Tablets begin their therapeutic effect 1-3 hours after they are taken. The digestive system perceives Concor well, which dissolves quickly and is absorbed into the bloodstream, while there is no dependence on the time of eating.

The drug is excreted from the body through the kidneys and liver. After taking the medicine, after 3 hours, the highest concentration of Concor is noted. The medical result is saved during the day.

The main medicinal properties of Concor include:

Of all the beta blockers, Concor is the most powerful and effective therapeutic agent, providing a long lasting effect. The greatest therapeutic effect, it turns out, when taking small and medium doses of the drug.

Release form and price

The drug is available in tablet form of 2.5 mg, 5 mg and 10 mg, covered with a thin film. The package contains 30 or 50 tablets.

The price of the drug depends on the dosage of the tablets. In Moscow pharmacies you can buy medicine from 210 rubles. for a package of 30 tablets or up to 550 rubles. for a pack of 50 tablets.

It contains 8 useful medicinal plants that are extremely effective in the treatment and prevention of arrhythmias, heart failure, atherosclerosis, coronary artery disease, myocardial infarction, and many other diseases. In this case, only natural ingredients are used, no chemicals and hormones!

Concor is prescribed when:

Methods of reception

Concor is prescribed for use no more than a single dose during the day in the morning before breakfast, washed down with a small amount of water, without chewing the tablets.

Overdose leads to bradycardia, arterial hypotension, bronchospasm, heart failure.

Contraindications for admission

The drug is not prescribed if the patient has:

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