Effective analogues of omeprazole. How to replace omeprazole with long-term use But it may be more correct to treat not the consequence, but the cause

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The medicine is indicated for diagnoses:

pancreatic adenoma;
different types of ulcerative lesions of the gastrointestinal tract.

Release the medicine in tablet form. Tablets have a fairly low cost (from 30 to 60 rubles), so the need to pick up analogues of Omeprazole, as a rule, arises if the patient has contraindications, or the specialist recommends taking a more effective (complex) medication or medication of another form of release.

Ranitidine

Analogue Ranitidine belongs to the group of drugs - blockers of histamine receptors (H2) located in the stomach. The action of the drug is designed to reduce the production of hydrochloric acid and prevent the subsequent destruction of the mucous membrane of the organ.

The composition of Ranitidine has the active substance of the same name, as well as additional components in the form of chemical elements.

The indications include:

prevention and treatment of diseases of the ulcerative (erosive) type of the gastrointestinal tract;
exacerbation of inflammation of the stomach, as well as 12 duodenal ulcer;
prevention of bleeding of the upper esophagus;
prevention of the passage of gastric juice into the respiratory tract.

Contraindications according to the instructions:

intolerance to one or more components contained in the composition;
period of pregnancy or breastfeeding;
childhood.

Ranitidine is sold in pharmacies in the form of tablets with a dosage of 150 or 300 mg. The cost of a medicine, depending on the manufacturer, varies from 16 to 60 rubles. Among inexpensive analogues - Ranitidine is the cheapest.

Omez

The drug - Omez, differs from other generics of the original drug in its complex effect. Omez is a universal medicine recommended even for mild forms of stomach pathologies.

The composition of Omez differs in the form of release. Pharmacies sell two types of capsules with different dosages of the active ingredient (omeprazole):

white - 10 mg;
transparent - 20 mg.

The drug is also sold in the form of a dry suspension for the preparation of an injection solution. As part of a dry product - 40 mg. active substance.

ulcerative pathologies of the stomach;
reflux of the gastrointestinal tract;
subinvestigative erosive inflammation after NSAIDs;
Zollinger syndrome;
pancreatitis;
dispersion.

Omez is contraindicated:

when feeding a child with mother's milk;
during gestation;
under the age of six;
when the body reacts to the composition;
in case of diagnosing bleeding; perforation or obstruction (mechanical) of the stomach or intestines;
with a pituitary tumor.

A wider range of action Omez is reflected in its price. An analogue of Omeprazole costs an average of 230 rubles.

Pantoprazole

For the treatment of violations of the process of secretion of hydrochloric acid in the stomach, I use modern drugs that contain pantoprazole as an active ingredient. The drug has the same name. Despite the fact that the active substance is different, its effect on the body is similar, so they can replace the original. Indications for taking tablets are similar.

Omeprazole analogues containing pantoprazole are a kind of synonyms for the original medication. A feature of the funds is that they are not contraindicated for lactating and pregnant women.

The price is from 170 to 300 rubles.

Nolpaza

Considering imported generics of the original remedy for blocking the increased release of hydrochloric acid, experts recommend paying attention to Nolpaza (Slovenia). The main active ingredient in the composition is pantoprazole at a dosage of 20 or 40 mg.

An analogue of Omeprazole is produced in the form of tablets containing, in addition to the active ingredient:

mannitol;
calcium stearate;
sorbitol;
sodium carbonate.

The complex action of the composition is aimed at normalizing the work of gastric secretion to prevent or treat ulcerative erosive diseases and their consequences.

Contraindications include:

neurotic dispersion;
liver pathology;
bleeding in the gastrointestinal tract;
hypovitaminosis.

In pharmacies, if it is necessary to replace Omeprazole, an analogue can be purchased for 150 rubles (20 mg dose) or 240 rubles (40 mg dose).

Emanera

The newest broad-spectrum gastrointestinal treatment is Emanera, one of the exceptional drugs that can be taken by children and adults, including pregnant women. The drug is developed on the basis of esomeprazole.

Indications:

gastritis;
peptic ulcer of the gastrointestinal tract;
erosion of the walls of the stomach;
bacterial lesion (bacterium Helicobacter pylori);
idiopathic hypersecretion;
increased secretion of gastric juice.

For children under twelve years of age, the medicine can only be prescribed by a doctor. Generics of omeprazole with esomeprazole are not recommended for diabetes, impaired renal function and allergies to the composition.

The price of the drug is from 250 to 700 rubles

Esomeprazole

The Russian analogue of the original medicine - Esomeprazole, which contains a substance with a similar ignorance, is the most ideal alternative to Omeprazole in terms of its action, as well as the price (up to 160 rubles on average).

Esomeprazole is produced in the form of tablets, as well as a lyophilisate used to dilute the injection solution.

Generic is prescribed for indications similar to the original drug, however, it is often used for prophylactic purposes.

Like many analogues, Esomeprazole is contraindicated in children, pregnant, lactating women and with intolerance to the substances that make up the drug. It is also prescribed with caution to people with renal insufficiency.

Pariet

The most expensive substitute for the original is Pariet. Its cost ranges from 850 to 3600 rubles. The difference in price depends on the dosage of the active substance and the number of tablets in the package.

Pariet was developed by the well-known company Johnson & Johnson. It contains a unique substance - rabeprazole sodium.

The analogue is used to treat the gastrointestinal tract, as well as to eliminate the symptoms of dispersion and gastritis associated with increased production of gastric acid:

belching;
heartburn;
vomiting with bile;
pain in the left hypochondrium.

Pariet should not be used in pregnant women, nursing mothers, children under 18 years of age and patients diagnosed with renal insufficiency.

Lansoprazole

Used for the treatment of erosive and ulcerative lesions of the stomach, Lansoprazole capsules in pharmacy chains are sold only with a prescription from the attending physician. The mechanism of action of the drug is based on the body's reaction to the main drug substance with the same ignorance - lansoprozole at a dosage of 15 mg or 30 mg.

Lansoprazole can be prescribed by a doctor for the following diagnoses:

erosive esophagitis;
gastrointestinal ulcers;
dispersion (non-ulcerative);
the presence of Helicobacter pylori.

In addition to contraindications similar to the previous drugs, Lansoprazole is forbidden to be taken for oncological pathologies of the gastrointestinal tract.

Price from 500 rubles.

Losek

Another prescription generic is Losek. Its cost can be from 300 to 400 rubles per pack. Indications include a list of pathologies of the stomach and duodenum associated with high production of acidity in the gastrointestinal tract.

The active substance is similar to the original drug. The release form has several types: capsules, tablets and powder for injection.

Contraindications:

gestation;
feeding the child with breast milk;
age under 16;
kidney / liver failure.

Losek is able to provoke multiple side effects, so its use is controlled by a doctor.

Rabeprazole

Rabeprazole capsules are used as a generic of Omeprazole tablets. The composition of the drug contains auxiliary substances of chemical origin, as well as the main component - rabeprazole sodium.

Rabeprazole has contraindications similar to the above medicines. This generic cannot be taken without a doctor's prescription, as it can cause serious side effects.

Cost: 140 - 240 rubles.

When deciding what to replace Omeprazole with, a person hardly thinks about buying cheaper pills for treatment, since this remedy has the lowest cost. However, if due to contraindications or side effects it is required to select analogues of the drug, then you should follow the doctor's recommendations.

Drugs for the treatment of excess stomach acid and peptic ulcer are very popular. Let's consider the most accessible and popular proton pump inhibitors (drugs of this class are usually called the abbreviation PPI or PPI for short), based on the active substance omeprazole and rabeprazole (a slightly modified analogue of the first).

The drug Omeprazole

10 popular analogues of omeprazole and rabeprazole

Omez (omeprazole). Indian product. Advantages: a variety of dosages, the presence of an injection form, which increases bioavailability, the cost is lower than other analogues, but higher than that of omeprazole. Disadvantages: the maximum concentration is reached for a long time, the half-life is short. The average price per pack is about 170 rubles.
Ultop (omeprazole). Producer Russia or Slovenia. Advantages: different dosages, injectable forms, high bioavailability, long half-life, relatively low cost (80-90 rubles). Disadvantages: long time to create maximum concentration.
Losek (omeprazole). Country Sweden. Advantages: injectable form, the maximum concentration is reached in a short time. Disadvantages: high price among all analogues - 1800 rubles.
Gastrozole (omeprazole). Russia. It is distinguished by high bioavailability, relatively low cost (100 rubles), varieties of packaging (jars, blisters). Disadvantages: only one dosage, shortened half-life.
Ortanol (omeprazole). Slovenia. Advantages: long half-life, variety of dosages, average price (90-100 rubles). Disadvantages: the maximum concentration is reached for a long time.
Helicide (omeprazole). Czech Republic. The bioavailability of capsules is higher than analogues, the presence of injection forms. Of the minuses - the high price (260-290 rubles).
(rabeprazole). Switzerland, Japan, Belgium. The disadvantage is the high price (1000-1300 rubles).
Rabelok (rabeprazole). India. Pros: Intravenous form (lyophilisate) providing high bioavailability. The cost is from 300 rubles.
Ontime (rabeprazole). Israel. It has the lowest bioavailability of all substitutes. The cost is 500 rubles.
Zolispan (rabeprazole). Spain. High bioavailability and half-life.

Drugs for the treatment of excess stomach acid and peptic ulcer are very popular. Consider the most affordable and popular proton pump inhibitors (drugs of this class are usually called the abbreviation PPI or PPI for short), based on the active substance omeprazole and rabeprazole (a slightly modified analogue of the first).

The drug Omeprazole

10 popular analogues of omeprazole and rabeprazole

Omez (omeprazole). Indian product. Advantages: a variety of dosages, the presence of an injection form, which increases bioavailability, the cost is lower than other analogues, but higher than that of omeprazole. Disadvantages: the maximum concentration is reached for a long time, the half-life is short. The average price per pack is about 170 rubles.
Ultop (omeprazole). Producer Russia or Slovenia. Advantages: different dosages, injectable forms, high bioavailability, long half-life, relatively low cost (80-90 rubles). Disadvantages: long time to create maximum concentration.
Losek (omeprazole). Country Sweden. Advantages: injectable form, the maximum concentration is reached in a short time. Disadvantages: high price among all analogues - 1800 rubles.
Gastrozole (omeprazole). Russia. It is distinguished by high bioavailability, relatively low cost (100 rubles), varieties of packaging (jars, blisters). Disadvantages: only one dosage, shortened half-life.
Ortanol (omeprazole). Slovenia. Advantages: long half-life, variety of dosages, average price (90-100 rubles). Disadvantages: the maximum concentration is reached for a long time.
Helicide (omeprazole). Czech Republic. The bioavailability of capsules is higher than analogues, the presence of injection forms. Of the minuses - the high price (260-290 rubles).
Pariet (rabeprazole). Switzerland, Japan, Belgium. The disadvantage is the high price (1000-1300 rubles).
Rabelok (rabeprazole). India. Pros: Intravenous form (lyophilisate) providing high bioavailability. The cost is from 300 rubles.
Ontime (rabeprazole). Israel. It has the lowest bioavailability of all substitutes. The cost is 500 rubles.
Zolispan (rabeprazole). Spain. High bioavailability and half-life.

The modern and effective drug omeprazole reduces the level of gastric secretion and suppresses the release of pepsin. The first dose of the drug gives a quick result, which explains its high popularity among patients.

Indications for the use of omeprazole include duodenal ulcer, gastric ulcer, hypersecretion, reflux esophagitis, gastropathy.

The drug is available in tablets, ampoules, capsules. The active substance is similar to the name of the drug - omeprazole. The drug is produced by a number of countries, including Russia, Belarus, India, as well as many European companies.

Prices for tablets from 20 rubles allow you not to look for cheap analogues of the drug, except in cases where there is an individual intolerance to the components in the medicine.

Analogues of Russian production

The Russian pharmaceutical market offers its own drugs similar to omeprazole.

Russian-made close substitutes are listed in the table:

Ukrainian substitutes

List of Ukrainian-made medicines that are analogues of omeprazole or its close substitutes:

Omeprazole Darnitsa. The price is 25 rubles. The drug is used to treat gastroesophageal reflux disease. Antiulcer drug.
Esonexa. The price is 75 rubles. The active substance is esoneprazole. Available in capsules. proton pump inhibitor.
Rabprazol Health. The price is 95 rubles. Successfully treats active ulcers of the duodenum, stomach, erosive reflux disease, Zollinger-Ellison syndrome.

Belarusian generics

When choosing how to replace omeprazole, pay attention to Belarusian generics, which are great for treating complex diseases. The price range for medicines allows them to be an excellent substitute for a cheap drug.

A list of some Belarusian synonyms is given below:

Omeprazole. The cheapest drug with omeprazole in the composition. The drug is available in the form of capsules, and is prescribed for adults and children strictly according to the doctor's prescription. It is not recommended during pregnancy. Price - 30 rubles.
Omeprazole Nika. Powder for the preparation of a solution for intravenous administration, with the active substance omeprazole. An anti-ulcer agent that effectively reduces the acidity of the stomach. Produced in the form of a powder, in ampoules, in a vial. The price is 75 rubles.

Other foreign analogues

Imported drugs with omeprazole are produced in large quantities by many countries. The best synonyms differ in cost and dosage.

Consider cheaper means, as well as expensive modern medicines:

A drug	Average cost in pharmacies	Peculiarities
Omez	From 180 rubles	The country of origin is India. The tool gives a persistent antisecretory effect from the first application. Available in the form of capsules.
Omeprazole Richter	From 75 rubles	Country of origin - Spain, Hungary. Antiulcer drug in the form of tablets. proton pump inhibitor. Prohibited in diseases of the liver.
Omeprazole Teva	From 77 rubles	Country of origin - Spain, Israel. The remedy lowers stomach acidity. Used for peptic ulcer of the gastrointestinal tract.
Omitox	From 130 rubles	The country of origin is India. The drug is prescribed for peptic ulcer of the stomach and duodenum, reflux esophagitis, Zollinger-Ellison syndrome.
Ortanol	From 105 rubles	Country of origin - Slovenia, Switzerland. The product is available in the form of capsules. It has indications for use and contraindications similar to omeprazole.
Pylobact	From 1420 rubles	The country of origin is India. Release form - a set of tablets and capsules or a set of ampoules. An effective anti-ulcer drug.
Ultop	From 125 rubles	Country of origin - Portugal, Slovenia. Capsules are prohibited during pregnancy, during breastfeeding, as well as children under 18 years of age. The active substance is omeprazole.

The instructions for the aforementioned drugs indicate that the effect of taking the medication occurs within two hours from the moment of use and lasts for 24 hours.

Daily single use normalizes the production of gastric juice and stabilizes the level of secretion. Omeprazole creates optimal conditions for the normal functioning of the organs of the gastrointestinal tract.

The remedy is taken one hour before meals with a full glass of water. The course of treatment should not exceed four weeks. The drug guarantees the elimination of symptoms, but the cause of the disease must be established together with the doctor. Remember, self-administration of medicines is prohibited!

International name

Omeprazole (Omeprazole)

Group affiliation

proton pump inhibitor

Dosage form

Capsules, enteric capsules, powder for solution for infusion, coated tablets

pharmachologic effect

Proton pump inhibitor, reduces acid production - inhibits the activity of H + / K + -ATP-ase in the parietal cells of the stomach and thereby blocks the final stage of HCl secretion. The drug is a prodrug and is activated in the acidic environment of the secretory tubules of parietal cells.

Reduces basal and stimulated secretion, regardless of the nature of the stimulus. The antisecretory effect after taking 20 mg occurs within the first hour, maximum after 2 hours. Inhibition of 50% of the maximum secretion lasts 24 hours.

A single dose per day provides a quick and effective inhibition of day and night gastric secretion, reaching its maximum after 4 days of treatment and disappearing by the end of 3-4 days after the end of the dose. In patients with duodenal ulcer, taking 20 mg of omeprazole maintains intragastric pH at 3 for 17 hours.

Indications

Peptic ulcer of the stomach and duodenum 12 (including prevention of relapse), reflux esophagitis, hypersecretory conditions (Zollinger-Ellison syndrome, stress ulcers of the gastrointestinal tract, polyendocrine adenomatosis, systemic mastocytosis); NSAID gastropathy.

Eradication of Helicobacter pylori in infected patients with gastric ulcer and duodenal ulcer (as part of combination therapy).

Contraindications

Hypersensitivity, childhood, pregnancy, lactation. With caution. Renal and / or liver failure.

Side effects

From the digestive system: diarrhea or constipation, abdominal pain, nausea, vomiting, flatulence; in rare cases - increased activity of "liver" enzymes, taste disturbances; in some cases - dry mouth, stomatitis, in patients with previous severe liver disease - hepatitis (including jaundice), impaired liver function.

On the part of the hematopoietic organs: in some cases - leukopenia, thrombocytopenia, agranulocytosis, pancytopenia.

From the nervous system: in patients with severe concomitant somatic diseases - dizziness, headache, agitation, depression, in patients with previous severe liver disease - encephalopathy.

From the musculoskeletal system: in some cases - arthralgia, myasthenia gravis, myalgia.

On the part of the skin: rarely - skin rash and / or itching, in some cases - photosensitivity, erythema multiforme exudative, alopecia.

Allergic reactions: urticaria, angioedema, fever, bronchospasm, interstitial nephritis and anaphylactic shock.

Others: rarely - gynecomastia, malaise, visual disturbances, peripheral edema, increased sweating, the formation of gastric glandular cysts during long-term treatment (a consequence of inhibition of HCl secretion, is benign, reversible).

Application and dosage

Inside, the capsules are usually taken in the morning, the capsules should not be chewed with a small amount of water (just before a meal or during a meal).

With exacerbation of peptic ulcer, reflux esophagitis and NSAID gastropathy - 20 mg 1 time per day. For patients with severe reflux esophagitis, the dose is increased to 40 mg 1 time per day. The course of treatment for duodenal ulcer - 2-3 weeks, if necessary - 4-5 weeks; with gastric ulcer and esophagitis - 4-8 weeks.

Patients resistant to treatment with other antiulcer drugs are prescribed 40 mg / day. The course of treatment for duodenal ulcer - 4 weeks, for gastric ulcer and reflux esophagitis - 8 weeks.

With Zollinger-Ellison syndrome - 60 mg; if necessary, the dose is increased to 80-120 mg / day (in this case, it is prescribed in 2-3 doses).

For the prevention of recurrence of peptic ulcer - 10 mg 1 time per day.

For the eradication of Helicobacter pylori, "triple" therapy is used (for 1 week: omeprazole 20 mg, amoxicillin 1 g, clarithromycin 500 mg - 2 times a day; or omeprazole 20 mg, clarithromycin 250 mg, metronidazole 400 mg - 2 times a day day; either omeprazole 40 mg 1 time per day, amoxicillin 500 mg and metronidazole 400 mg - 3 times a day) or "double" therapy (for 2 weeks: omeprazole 20-40 mg and amoxicillin 750 mg - 2 times a day day or omeprazole 40 mg - 1 time per day and clarithromycin 500 mg - 3 times a day or amoxicillin 0.75-1.5 g - 2 times a day). A special dosing regimen. In case of liver failure, 10-20 mg are prescribed; in case of impaired renal function and in elderly patients, correction of the dosing regimen is not required.

special instructions

Before starting therapy, it is necessary to exclude the presence of a malignant process (especially with a stomach ulcer), because. treatment, by masking symptoms, may delay the correct diagnosis.

Taking it with food does not affect its effectiveness.

Interaction

May reduce the absorption of ampicillin esters, Fe salts, itraconazole and ketoconazole (omeprazole increases gastric pH).

Being inhibitors of cytochrome P450, it can increase the concentration and reduce the excretion of diazepam, indirect anticoagulants, phenytoin (drugs that are metabolized in the liver through cytochrome CYP2C19), which in some cases may require a reduction in doses of these drugs.

At the same time, long-term use of omeprazole at a dose of 20 mg once a day in combination with caffeine, theophylline, piroxicam, diclofenac, naproxen, metoprolol, propranolol, ethanol, cyclosporine, lidocaine, quinidine and estradiol did not lead to a change in their plasma concentration.

Enhances the inhibitory effect on the hematopoietic system of other drugs.

There was no interaction with concomitantly taken antacids.