In this medical article, you can get acquainted with the drug Phosphogliv. The instructions for use will explain in which cases you can take Forte capsules or tablets, injections in ampoules, what the medicine helps with, what are the indications for use, contraindications and side effects. The annotation presents the form of release of the drug and its composition.
In the article, doctors and consumers can only leave real reviews about Phosphogliv, from which you can find out if the drug helped in the treatment of hepatitis and cirrhosis in adults and children, for which it is also prescribed. The instructions list the analogues of Phosphogliv, the prices of the drug in pharmacies, as well as its use during pregnancy.
Phosphogliv is a membrane stabilizing, hepatoprotective and antiviral drug. Instructions for use recommends taking Forte capsules or tablets, injections in ampoules for injections for the treatment of cirrhosis of the liver, fatty degeneration of the liver, and viral hepatitis.
Release form and composition
Phosphogliv is available in the form of capsules for oral administration and a lyophilisate for the preparation of a solution for intravenous administration. Capsules are placed in 10 pcs. in cellular packaging. There are 5 packs in a carton box.
The lyophilizate is sold in glass bottles of 2.5 g each. There are 5 bottles in a carton box complete with a solvent - 5 ampoules of water for injection.
The composition of 1 bottle with lyophilizate for the preparation of an injection solution includes active substances: phospholipids (C 100 lipoid), sodium glycyrrhizinate.
The composition of 1 capsule includes active substances: phospholipids (lipoid C 80), sodium glycyrrhizinate (trisodium salt of glycyrrhizic acid).
pharmachologic effect
Phosphogliv instructions for use refers to combined drugs that have a membrane-stabilizing, hepatoprotective and antiviral effect.
Glycyrate has anti-inflammatory properties, inhibits the reproduction of viruses in the liver and other organs by stimulating the production of interferons, enhancing phagocytosis, and increasing the activity of natural killer cells. It has a hepatoprotective effect.
Phosphatidylcholine is the main structural element of cellular and intracellular membranes, capable of restoring their structure and functions in case of damage, exerting a cytoprotective effect. It normalizes protein and lipid metabolism, prevents the loss of enzymes by hepatocytes, restores the detoxifying function of the liver, inhibits the formation of connective tissue, and reduces the risk of fibrosis and cirrhosis of the liver.
With skin lesions, due to the membrane-stabilizing and anti-inflammatory properties, it limits the spread of the process and contributes to the regression of the disease.
What helps Phosphogliv?
Indications for the use of the drug include:
- cirrhosis of the liver (simultaneously with other drugs);
- psoriasis (simultaneously with other drugs);
- fatty degeneration of the liver (hepatosis);
- alcoholic, medicinal, toxic liver damage;
- eczema, neurodermatitis (injection solution);
- intoxication (injection solution);
- acute and chronic viral hepatitis (simultaneously with other drugs).
Instructions for use
Capsules Phosphogliv (Forte)
Capsules are taken orally, without chewing, during meals, washed down with a small amount of water. The recommended dosage regimen for children over 12 years of age and adult patients is 2 capsules 3 times a day. The duration of treatment with the drug is from 3 to 6 months.
Lyophilisate
Dissolve in 10 ml of water for injection. The solution is administered intravenously, slowly.
Adults and children over 12 years of age are usually prescribed 10 ml daily 2 times / day in the morning and evening for 10 days. Then it is recommended to switch to oral administration of the drug in the form of capsules. The duration of the course can be increased according to the doctor's prescription.
Contraindications
- antiphospholipid syndrome.
- hypersensitivity to glycyrrhizic acid, phosphatidylcholine or other components of the drug Phosphogliv, from which side effects may develop;
- pregnancy (data on efficacy and safety are not enough);
- children under 12 years of age (data on efficacy and safety are not enough);
- lactation period (breastfeeding);
Side effects
Children, during pregnancy and lactation
The drug Phosphogliv is contraindicated for use during pregnancy and lactation. The drug is not prescribed to patients under 12 years of age.
special instructions
In the event of an increase in blood pressure, Phosphogliv therapy should be discontinued and a doctor should be consulted.
The drug does not adversely affect the ability to drive vehicles and do other work that requires quick psychomotor reactions and high concentration.
drug interaction
Phosphogliv in the form of a lyophilisate cannot be mixed with other solutions. For dissolution it is possible to use only water for injections. Glucose solution or saline sodium chloride solution should not be used to dilute the drug.
Phosphogliv's analogs
There are no complete analogues. The group of hepatoprotectors include:
- Essliver.
- Lipoid PPL 400.
- Lipoid C 100.
- Betaine citrate.
- Silegon.
- Lipoic acid.
- Sirepar.
- Berlition 300.
- Geptrong.
- Silimar.
- Erbisol.
- Tykveol.
- Urso 100.
- Glutargin.
- Silymarin.
- Hepatofalk planta.
- Essentiale forte N.
- Phosfonciale.
- Molixan.
- Methionine.
- Ornitsetil.
- Milife.
- Livodex.
- Hepabos.
- Silibinin.
- Ursoliv.
- Hepa-Merz.
- Exhol.
- Cryomelt.
- Ursor.
- Alpha Lipoic Acid.
- Ursosan.
- Phosphogliv Forte.
- L-Methionine.
- Choludexan.
- Ursodez.
- Berlition 600.
- Livolife Forte.
- Cavehol.
- Karsil Forte.
- Resolution Pro.
- Ursofalk.
- Brenciale forte.
- Essentiale N.
- Heptral.
- Maksar.
- S-adenosylmethionine.
- Urdox.
- Heptor.
- Ursodeoxycholic acid.
- Karsil.
- Thiolipon.
- Antraliv.
- Hepatosan.
- Octolipen.
- Thiotriazoline.
- Ursodex.
- Legalon.
- Vitanorm.
- Essential phospholipids.
Holiday conditions and price
The average price of Phosphogliv (capsules No. 50) in Moscow is 493 rubles. In Kyiv, you can buy medicine for 255 hryvnia, in Kazakhstan - for 3720 tenge. Pharmacies in Minsk offer the drug for 16-17 bel. rubles. It is released from pharmacies by prescription.
This is a combination drug, the main function of which is hepatoprotective. The drug has regenerating, membrane-stabilizing and antiviral activity.
The drug Phosphogliv indications for use
The drug is used in combination in the treatment of the underlying disease, and in the future as a monotherapy drug. Main indications:
Viral hepatitis (acute and chronic forms)
Cirrhosis of the liver
Toxic damage to the liver
Alcoholic hepatitis
Non-alcoholic liver diseases (steatohepatitis, steatohepatosis)
Complex therapy of skin diseases (psoriasis, eczema, neurodermatitis)
Detoxification therapy
Contraindications
Individual hypersensitivity to the components of the drug
Children under the age of 12
Hypertension (arterial, portal)
Antiphospholipid Syndrome
During pregnancy and breastfeeding
The composition of the tablets
Each capsule is a hard brown gelatin capsule containing phospholipids - 65 mg, sodium glycyrrhizin - 35 mg. Excipients - silicon dioxide, talc, calcium stearate, calcium carbonate, microcrystalline cellulose.
Phosphogliv instructions for use in capsules
Capsules for oral administration. For better absorption of the drug, it is recommended to take the tablets with meals, drinking plenty of non-carbonated water.
The standard course of treatment for acute liver damage lasts 30 days, 1-2 capsules per day 3-4 times during meals. The dose should be adjusted depending on individual tolerance, improvement or deterioration of the patient's condition. In the chronic course of the disease - a course of half a year continuously, or 2-3 months, with a break of 1 month between doses.
Phosphogliv instructions for use in ampoules
The solution for injection is administered exclusively intravenously slowly (!), Dissolving the contents of 1 vial (2.5 g of lyophilized powder) in 10 ml of water for injection. In the acute course of the disease - 1-2 times a day for 1 month, in the chronic form - 3 times a week for up to six months.
Dosage in tablets
One tablet contains the following composition: sodium glycyrrhizinate 32 mg and phospholipids (phosphatidylcholine 73-79%) - 65 mg.
Phosphogliv injections - indications and instructions for use
Injections are used for acute liver damage, for outpatient treatment of chronic hepatitis, preparing the patient for an upcoming surgical intervention and after, severe intoxication and skin lesions.
Phosphogliv analog - Antral, Gepaforte, Karsil, Essentiale.
What is the difference between Phosphogliv forte and Phosphogliv
The main difference between medicines is the concentration of active substances in one tablet. It is much more pleasant to drink one tablet twice a day, or 2 tablets 4 times a day. The composition of Phosphogliv is listed as: 65 mg + 35 mg in 1 capsule.
Forte contains: 300 mg + 65 mg. However, in terms of effectiveness, both drugs are not inferior to each other.
By-effect
The drug is usually well tolerated by patients. Possible skin manifestations of hypersensitivity (itching and rash). When the reception is canceled, all skin elements disappear. Glycyrrhizic acid at high concentrations rarely causes a pseudocorticosteroid effect, with an increase in the level of hormones in the blood, which entails water and sodium retention, a decrease in potassium concentration and arterial hypertension. Possible cough, dyspeptic disorders.
Capsules, lyophilisate for solution for intravenous administration
Hard gelatin capsules No. 0, the capsule body is orange, the lid is black. The contents of the capsule is a granular powder from white with a slightly yellowish tint to light yellow, with a slight specific odor.
30, 50, 100, 200 or 300 capsules in plastic containers with HDPE or propylene lids.
10 capsules in a blister pack made of PVC film and aluminum foil.
1 container or 2, 3, 5 blister packs together with instructions for use are placed in a cardboard box.
Lyophilisate in a package of 5 and 10 vials.
Composition and active substance
Phosphogliv contains:
Phosphogliv Capsules
1 capsule contains:
Active substances: Phospholipids (Lipoid C 80) (in terms of 100% substance) (the main component is phosphatidylcholine 73-79%) - 65 mg, sodium glycyrrhizinate (trisodium salt of glycyrrhizic acid) - 35 mg.
Excipients: microcrystalline cellulose - 141.2 mg, calcium carbonate - 204.7 mg, calcium stearate - 0.9 mg, talc - 7.7 mg, colloidal silicon dioxide (aerosil) - 5.5 mg, hard gelatin capsules - 96.0 mg [body: dye sunset yellow (E110) - 1.0%, titanium dioxide (E171) - 1.0%, gelatin - up to 100.0% cap: titanium dioxide (E171) - 0.2% , iron dye black oxide (E172) - 3.5%, gelatin - up to 100.0%].
Phosphogliv forte Capsules
1 capsule forte contains:
Active substances: lipoid PPL-400 400 mg, phospholipids (the main component is phosphatidylcholine 73-79%) 300 mg, sodium glycyrrhizinate 65 mg
Excipients: butylated hydroxytoluene, ethanol (luxury or extra grade), sunflower oil or corn oil
The composition of the capsule shell: titanium dioxide, iron dye red oxide, iron dye black oxide, iron dye yellow oxide, gelatin.
Phosphogliv Lyophilizate for solution for intravenous administration
1 vial with lyophilisate contains:
Active substances: phospholipid - 500 mg, glycyrate - 200 mg.
pharmachologic effect
Combined remedy. It has a membrane-stabilizing, hepatoprotective and antiviral effect.
Phosphatidylcholine (the active substance of phospholipids) is the main structural element of cellular and intracellular membranes, capable of restoring their structure and functions when damaged, providing a cytoprotective effect. It normalizes protein and lipid metabolism, prevents the loss of enzymes and other active substances by hepatocytes, restores the detoxifying function of the liver, inhibits the formation of connective tissue, reducing the risk of fibrosis and cirrhosis of the liver.
Glycyrrhizic acid has an anti-inflammatory effect, inhibits the reproduction of viruses in the liver and other organs by stimulating the production of interferons, increasing phagocytosis, and increasing the activity of natural killer cells. It has a hepatoprotective effect due to antioxidant and membrane stabilizing activity. Potentiates the action of endogenous glucocorticosteroids, providing anti-inflammatory and anti-allergic effects in non-infectious liver lesions.
With skin lesions, due to the membrane-stabilizing and anti-inflammatory action of the components, it limits the spread of the process and contributes to the regression of the disease.
Pharmacokinetics.
Phosphatidylcholine
More than 90% of ingested phospholipids are absorbed in the small intestine. Most of them are cleaved by phospholipase A to 1-acetyl-lysophosphatidylcholine, 50% of which undergoes reverse acetylation into polyunsaturated phosphatidylcholine during absorption in the intestinal mucosa. Polyunsaturated
Phosphatidylcholine enters the bloodstream with the lymph flow, from where, mainly in the form associated with high-density lipoproteins, it enters the liver. Pharmacokinetics in humans has been studied using radioactively labeled dilenoleyl phosphatidylcholine with 3H (choline moiety) and 14C (linoleic acid residue). The maximum concentration of 3H is reached after 6-24 hours, accounting for 19.9% of the prescribed dose of 14C - after 4-12 hours, accounting for 27.9%. The half-life of the choline component is 66 hours, the linoleic acid residue is 32 hours. In feces, 2% 3 H and 4.5% - 14 C are found in the urine - 6% 3 H and a minimum amount of 14 C. Both isotopes are absorbed in the intestine by more than 90%.
Glycyrrhizic acid
After oral administration in the intestine, under the influence of the enzyme &beta-glucuronidase produced by bacteria of normal microflora, an active metabolite, &beta-glycyrrhetic acid, is formed from glycyrrhizic acid, which is absorbed into the systemic circulation. In the blood, &beta-glycyrrhetic acid binds to albumin and is almost completely transported to the liver. Excretion of &beta-glycyrrhetic acid occurs mainly with bile, in residual amounts with urine.
According to experimental data, phospholipids improve the lipophilic properties of glycyrrhizic acid, increasing the intensity and rate of its absorption by more than 2 times.
What helps Phosphogliv: indications
– Fatty degeneration of the liver (hepatosis), alcoholic, toxic, including medicinal, liver damage
- As part of the complex therapy of viral hepatitis (acute and chronic), liver cirrhosis and psoriasis.
Contraindications
Hypersensitivity to glycyrrhizic acid, phosphatidylcholine or other components of the drug
Antiphospholipid Syndrome
Pregnancy (data on efficacy and safety are not enough)
Breastfeeding period (data on efficacy and safety are not enough)
Children under 12 years of age (data on efficacy and safety are not enough).
Phosphogliv during pregnancy and breastfeeding
The drug is contraindicated for use during pregnancy and lactation.
Phosphogliv: instructions for use
Capsules
It is taken orally, during meals, without chewing, with a small amount of liquid.
Lyophilisate
The injection solution is administered intravenously after dissolving 2.5 g (1 bottle) of dry lyophilized powder in 10 ml of pyrogen-free water (water for injection).
In the acute form of the disease, the drug is administered 1 or 2 times a day for 10-30 days, in the chronic form 1 time every other day or 3 times a week for 6-12 months. After the end of the intravenous course, therapy can be continued with Phosphogliv in capsules - 2 capsules 3 times a day for 30 days in acute and 6-12 months in the chronic form of the disease.
Side effects
Allergic reactions: skin rash, difficulty in nasal breathing, conjunctivitis, cough.
From the side of the cardiovascular system: transient (transient) increase in blood pressure, peripheral edema.
If these symptoms occur, you should stop taking the drug and consult a doctor.
special instructions
In patients with portal hypertension. In patients with arterial hypertension. In the presence of these diseases, before taking the drug, you should consult with your doctor.
In the event of an increase in blood pressure, stop taking the drug and consult a doctor.
The drug does not adversely affect the ability to drive vehicles and perform other work that requires increased concentration and speed of psychomotor reactions.
Compatibility with other drugs
Not described.
Overdose
Not described.
Storage conditions and shelf life
Store at a temperature not exceeding 25 °C. Keep out of the reach of children.
Phosphogliv (Phosphogliv) will help restore liver cells and eliminate the causes of its damage. But this is not the only therapeutic effect of the drug. How effective is Phosphogliv intravenously, the instructions for use of which convince of the combined action and complete safety of use?
What does it consist of?
Phosphogliv is a product of the largest Russian pharmaceutical company Pharmstandard (Kursk), which can only be purchased with a prescription after a doctor's appointment. This is the only drug for the treatment of the liver, the components of which are 2 active ingredients. For intramuscular and intravenous administration, it is produced in the form of a lyophilizate for the preparation of a solution.
Lyophilization as a method of drying substances allows avoiding high temperatures, preserving the structure and biological activity of the drug.
One vial contains:
- 0.50 g of phospholipids (Lipoid C100) - the main components of cell membranes;
- 0.20 g of trisodium salt of glycyrrhizic acid (sodium glycyrrhizinate), which has anti-inflammatory and antioxidant effects;
- 1.80 g maltose, excipient.
Inside the glass vials is a white or light yellow powder. 1 package contains 5 vials of 2.5 g each. They can be stored for 24 months from the date of manufacture. Best in a dark, cool place out of the reach of children.
Therapeutic effect
As already noted, the drug has a complex effect:
- Stabilizes cellular and intracellular membranes. When damaged, restores their structure, protects.
- It is a hepatoprotector. Normalizes protein-lipid metabolism. Restores liver function, inhibiting the growth of connective tissue. Protects cells from loss of enzymes, reduces the risk of developing fibrosis and cirrhosis of the liver.
- Destroys viruses in the liver. The drug has an anti-inflammatory effect, stimulating the production of interferons, phagocytes and increasing their activity.
- Reduces allergic processes in non-infectious liver lesions.
- The combined effect is a distinctive feature of Phosphogliv from similar drugs.
Indications and contraindications
Phosphogliv is prescribed by doctors for diseases associated with liver pathologies:
- Hepatitis provoked by viruses. Inflammation of the glandular tissue of the organ is extremely dangerous for humans and can lead to complete atrophy of the liver.
- Hepatosis, which is otherwise called fatty degeneration of the liver. Pathology is caused by a metabolic disorder in the liver cells. The root cause is the excessive intake of fats in food.
- Drug or alcohol intoxication. Occurs in response to a poison or toxin entering the body.
- Cirrhosis. In the liver, an irreversible process of replacing the glandular tissue with connective tissue occurs, in connection with which the organ loses some of its functions. The disease usually occurs as a result of various types of hepatitis and alcoholism.
- Psoriasis. The disease is considered skin, but among the root causes are called including pathologies of the liver.
Phosphogliv is also used to treat neurodermatitis and eczema. These are diseases that occur most often as a result of allergies. The drug normalizes the patient's condition, neutralizing allergens and toxins. Neurodermatitis and eczema with injections of Phosphogliv pass in a shorter time.
But the drug can not always be used. An obstacle to treatment with Phosphogliv may be:
- intolerance to components;
- the period of bearing and feeding a child;
- age up to 12 years.
Pregnant, lactating women and children are the most vulnerable categories. In case of urgent need, Phosphogliv can also be used to treat them. But these studies have not been conducted, so it is better not to risk it.
Simultaneous treatment with alcohol is strictly prohibited. It neutralizes the protective effect of the drug, and in large doses it aggravates the situation and destroys all the results of treatment. Even small doses of alcoholic and low-alcohol drinks should be excluded.
For prevention
Phosphogliv is used not only for exacerbations or in the chronic course of the disease. Often it is used for prevention:
- with stress;
- malnutrition and overeating;
- little physical activity;
- poor environmental conditions;
- taking alcoholic beverages;
- taking medicines.
Phosphogliv easily copes with weakness in the abdomen, bloating, discomfort and pain in the abdomen. Discomfort will pass in a short time.
But even for the prevention and removal of painful symptoms, it is recommended to consult a doctor.
The components of the drug are absorbed in the small intestine almost completely. But first they enter the bloodstream and thus reach the liver. The maximum concentration of the components is reached after 6 hours or even a day. Dispatched within 2 days.
How to use correctly?
The treatment procedure takes place in 2 stages. First, the lyophilisate is dissolved in water for injection - 1 vial of 2.5 g per 10 ml. The solution is prepared immediately before the injection: it is better not to use previously prepared one. Then slowly administered intravenously or intramuscularly. Not intended for droppers.
The powder must not be diluted with saline, nor mixed with other solutions.
If the patient has an acute form of pathology, then the procedure is repeated 1 to 2 times a day. Treatment is continued for a month. If it has flowed into a chronic one, then therapy can be delayed up to six months or even a whole year. Then the injections are changed to capsules: 2 pieces three times for at least a month with an exacerbation and at least 6 months with a chronic course. As a rule, the duration of application is not limited.
Side effects
The safety of Phosphogliv is high - experts talk about the so-called favorable safety profile. Studies of the drug have shown that side effects are rare - in 1 out of 10,000 people.
But this one, when injected, may develop allergic urticaria. When the drug is discontinued, it disappears immediately. If you exceed the daily dosage, then sodium and fluids are retained in the tissues. They provoke:
- swelling;
- high blood pressure;
- hypokalemia, low concentration of ions in the blood.
To get rid of these symptoms, it is recommended to reduce the dosage or prescribe spironolactone. It is a diuretic that does not flush out potassium from the body. Its daily dose is 50-100 mg.
Phosphogliv does not affect psychomotor reactions and concentration. So, when treating the liver, you can confidently drive a car or control any other complex mechanism.
Other forms and analogues of Phosphogliv
The pharmaceutical company produces the drug not only in the form of injections. On the windows of pharmacies you can see:
- Phosphogliv capsules (Pharmstandard). 1 pack contains 30, 50, 100, 200 and 300 pieces. They are gelatinous, inside they contain a light yellow powder.
- Phosphogliv Forte capsules (Pharmstandard). The dose of active ingredients here is higher than in other forms.
The therapeutic effect of the capsules is achieved due to exactly the same active ingredients as those of the lyophilisate. They have the same indications, contraindications and side effects. Only the treatment regimen may differ. After taking it is recommended to drink water.
What injections can Phosphogliv replace? There are no injections with exactly the same composition. But Phosphogliv has plenty of analogues in action. These include:
- Heptor (Russia). Produced in the form of a lyophilisate in vials of 400 mg. The active substance is ademetionine. Used intramuscularly and intravenously. It acts not only as a hepaprotector, but also as a psychotropic drug.
- Heptral (Italy). It is similar in composition, action and use to Heptor.
- Laennec (Japan). It is an immunomodulatory and hepatoprotective drug. The main component is the hydrolyzate of the human placenta. Available as a solution for injection. In 1 ampoule - 2 ml.
- Remaxol (Russia). The main components of the injection solution are succinic acid, meglumine, methionine, riboxin and nicotinamide. The advantage of the drug is its low price.
- Essentiale N (France). The main constituents are phospholipids. The solution for injection is available in 5 ml vials. Intended for intravenous administration only.
- Gepa-Merz (Germany). Available in the form of a concentrate for the preparation of infusions. Ornithine plays the main role in the therapeutic effect.
- Berlition 600 (Germany). The ampoules contain thioctic acid.
The solution for injection is usually used for exacerbation. To maintain the condition and prevention, specialists most often choose capsules and tablets.
The cost of Phosphogliv and analogues
Treatment with injectable forms of hepaprotectors will cost the patient quite expensive. After all, liver therapy can last several months, especially with serious diagnoses. Compare:
- Phosphogliv in ampoules (5 pieces) costs 1529 rubles;
- Heptor (5 pieces) - 1475 rubles;
- Heptral (5 pieces) - 1851 rubles;
- Laennec (10 pieces) - 12369 rubles;
- Remaxol (400 ml) - 411 rubles.
- Hepa-Merz (10 pieces) - 2739 rubles.
- Berlition 600 (5 pieces) - 933 rubles.
For injections, Phosphogliv is an average price tag (compared to others), but the drug combines the therapeutic capabilities of two at once. Therefore, purchasing it even at a high price, the patient saves significantly. And be completely confident in the quality of the pharmacological product.
Sodium bicarbonate - use in therapy
Everything you need to know about heparin, or how to inject in the stomach without fear
Beauty injections for the face - the main positive aspects
