Unfortunately, in recent years, the number of people suffering from chronic rhinitis and seasonal allergies has been increasing. A nasal spray from the Indian manufacturer Momat Rino Advance can help in solving this problem.

The nasal spray has a unique anti-inflammatory and anti-allergic effect, which allows you to quickly get rid of allergic rhinitis, itching in the nose and tearing that occur during the exacerbation of allergies.

The drug is intended exclusively for topical use - intranasally, that is, the drug is injected into the nasal cavity through a special nasal dispenser, which is very convenient, since the dosage of the drug is always controlled.

The composition and form of release of the spray

The drug Momat Rino Advance is available in the form of a metered nasal aerosol, which is a light white suspension. Each bottle of the drug is designed for 150 doses. The bottle comes with a dosing device and a special nasal adapter.

The components that make up the aerosol

The main active elements of the spray mometasone furoate and azelastine hydrochloride.

Auxiliary components included in the nasal spray:

Medication Momat Rino is a nasal drug that belongs to the H1 anti-inflammatory drugs - a blocker of histamine receptors and glucocorticosteroid groups of drugs intended for topical use.

The action of the drug

Azelastine hydrochloride has long-term anti-allergic effect on the patient's body. In addition, this active substance helps to reduce capillary permeability and reduce exudate production. Also, this component has an antihistamine and membrane-stabilizing effect.

The second active element that is part of the drug is mometasone, which is a synthetic GCS, has not only anti-inflammatory, but also anti-allergic effect. This element also helps to block the release of allergy mediators.

Indications for use

Contraindications

Like most other pharmacological medicines, this nasal spray has some contraindications to be considered before use:

It should also be noted that the use of singing is prohibited for women during the period of gestation and lactation. This is due to the toxic effect that the active ingredient that is part of the drug, azelastine hydrochloride, can have.

Overdose

Cases of drug overdose have not been identified. However, if for some reason it gets inside (through the mouth into the stomach), adverse effects may develop, which are expressed as follows:

• malfunctions of the central nervous system - increased heart rate, weakness, drowsiness, confusion of thought and severe lethargy;
• with prolonged use of the spray in high doses in combination therapy with other medicines, the patient may experience such failures as: deterioration of the adrenal glands, dysfunction in the pituitary gland and hypothalamus.

If you take the drug according to the instructions, the likelihood of an overdose will be reduced to zero.

Possible adverse reactions

With prolonged use of the drug or violation of the dosages established by the instructions, in rare cases, patients may develop some adverse reactions from the body.

In some cases, the use of Momat Reno Advance Spray may cause an unpleasant taste in the patient's mouth. However, this is nothing more than a consequence of improper use - you just should never very much, when instilling your nose, tip your head back.

Momat Rino Advance: instructions for use and dosing rules

The drug is administered intranasally. The injection of the suspension contained in the vial is carried out by using a special nozzle that is attached to this vial.

Medication dosage

• the drug is recommended to be used one dose (1 injection) at a time in each nostril. The number of injections should not exceed two times a day: in the morning and in the evening. The course of therapy should not be more than two weeks.

How to use the dispenser correctly

Momat Reno Advance: the price of a medicine

nasal spray cost in different pharmacies ranges from 450 to 650 rubles (150 doses). It should also be noted that the price of a medicine directly depends on the shape and packaging of the spray. You can buy a medicine in almost any pharmacy, the main thing is to have a doctor's prescription with you, since the medicine is dispensed only by prescription. In free sale, the drug is not sold.

Popular analogues of the drug

It should be noted that Momat Rino Advance Spray has no complete analogues. However, there is good substitutes, based on the active substance mometasone or azelastine:

Each analogue includes only one active component - azelastine or mometasone, while Momat Rino Advance Spray includes two active elements at once. Before using the selected analogue, you should first consult with a specialist.

Momat Reno Advance: reviews of real patients

On the Internet you can find many positive reviews on the effectiveness of Momat Rino Nasal Aerosol. Some of them are presented below.

“In addition to the fact that I am allergic and constantly suffer from a terrible runny nose in spring and summer, I also have a cat - the child asked how to refuse. I can’t express how much I suffered with constant sneezing, itchy nose and itchy eyes, I just can’t convey. At one point, I finally decided to seek help from a specialist. I was prescribed Momat nasal aerosol. I tried it and it really helps! The course was prescribed for 14 days, I dripped it for only 4 days, and the effect is obvious. I can say that this spray is really good, so I can recommend it to all people who have the same problems as me. Just remember that the medicine is hormonal, so they should not be abused and self-medicate.

Evgeniya F.

“I read every review on the Internet before I decided to use Momat Rino Advance Spray. I got the medicine not so long ago - I'm allergic, and constantly, in the spring and summer, I suffer from severe rhinitis. I can say that the first time I didn’t feel a noticeable effect from the nasal spray - snot flowed like water, my eyes itched, everything in my nose itched and itched as before. However, I did not take into account the dosage that the therapist prescribed for me - it was necessary to spray not once, but twice a day. As soon as I began to do everything right, the effect was not long in coming - literally on the second day of using the medicine, all signs of rhinitis began to gradually recede.

The most important thing here is to observe the dosage. And in no case should you self-medicate, since this medicine has one drawback - it is hormonal. Other than that, this nasal spray is amazing."

“My mother has been suffering from severe allergies for a long time, which is also associated with asthma. Her therapist recently prescribed a course of nasal aerosol Momat Rino. I can say that the positive effect of the drug was noticed immediately after the first use. As a result of the use of this drug, all the signs of allergies disappeared in just a few days. Given that the course of therapy is only 2 weeks. I can say for sure, my review is in favor of that medication. He has no shortcomings. Well, except for the unpleasant aftertaste in the mouth after injections. However, this shortcoming passes very quickly.

Instruction:

Clinical and pharmacological group

04.010 (GKS for external use)

Release form, composition and packaging

Cream for external use 0.1% white.

Excipients: white soft paraffin, white beeswax, propylene glycol monostearate.

5 g - aluminum tubes (1) - packs of cardboard.

pharmachologic effect

Preparation for external use.

Mometasone is a synthetic GCS with anti-inflammatory, antipruritic and anti-exudative action. GCS induce the release of lipocortin proteins that inhibit phospholipase A2, which control the biosynthesis of inflammatory mediators (prostaglandins, leukotrienes) by inhibiting the release of their common precursor, arachidonic acid.

Pharmacokinetics

Suction

Absorption of ointment and cream Momat is negligible. 8 hours after a single application of the drug to intact skin (without an occlusive dressing), about 0.7% (ointment) and 0.4% (cream) of the active substance are found in the systemic circulation.

Metabolism

Mometasone is extensively metabolized in the liver.

breeding

It is excreted mainly by the kidneys and in small amounts with bile. T1 / 2 of mometasone from Momat ointment is approximately 5.8 hours.

Dosage

Outwardly. A thin layer of ointment or cream Momat is applied to the affected areas of the skin 1 time / day. The duration of the course of treatment is determined by its effectiveness, tolerability of the drug, as well as the presence and severity of side effects.

Overdose

Symptoms: depression of the function of the hypothalamic-pituitary-adrenal system, including secondary adrenal insufficiency.

Treatment: symptomatic, if necessary, carry out a correction of the electrolyte balance, drug withdrawal (with long-term therapy - gradual withdrawal).

drug interaction

Studies of drug interactions of the ointment and cream Momat with other drugs have not been conducted.

Use during pregnancy and lactation

The safety of using mometasone furoate during pregnancy and lactation (breastfeeding) has not been established.

GCS penetrate the placental barrier. Long-term treatment and the use of high doses during pregnancy should be avoided due to the threat of negative effects on fetal development.

GCS are excreted in breast milk. In the case when the use of corticosteroids in large doses and / or for a long time is expected, breastfeeding should be stopped.

Side effects

From the endocrine system: when using external forms of corticosteroids for a long time and / or for treatment on large areas of the skin, or using occlusive dressings, especially in children and adolescents - adrenal insufficiency, Cushing's syndrome.

Dermatological reactions: rarely - skin irritation, dry skin, burning sensation, folliculitis, hypertrichosis, acne, hypopigmentation, perioral dermatitis, skin maceration, secondary infection, signs of skin atrophy, striae, prickly heat; less than 1% of cases - the formation of papules, pustules.

Allergic reactions: rarely - itching, allergic contact dermatitis.

Terms and conditions of storage

The drug should be stored out of the reach of children, dry, dark place at a temperature not exceeding 25 ° C; do not freeze. Shelf life - 2 years.

Indications

For cream

- inflammation and itching in dermatoses amenable to glucocorticosteroid therapy.

- inflammation and itching in dermatoses (psoriasis, atopic dermatitis, seborrheic dermatitis), amenable to glucocorticosteroid therapy, in adults and children over 2 years old.

Contraindications

- rosacea;

- perioral dermatitis;

- bacterial, viral (Herpes simplex, chickenpox, Herpes zoster) or fungal infections of the skin;

- tuberculosis, syphilis;

- post-vaccination reactions;

- children's age up to 2 years (for ointment);

- pregnancy (use on large areas of the skin, long-term treatment);

- lactation period (use in high doses and / or for a long time);

- hypersensitivity to corticosteroids or to the components of the drug.

With caution, the drug should be applied to intertriginous skin and facial skin, used with occlusive dressings, on large areas of the skin and / or for a long period of time (especially in children).

special instructions

When applying the drug to large areas of the skin for a long time, especially when using occlusive dressings, it is possible to develop signs of suppression of the function of the hypothalamic-pituitary-adrenal system and the development of Cushing's syndrome.

Avoid getting Momat ointment and cream on the mucous membrane of the eye.

Propylene glycol, which is part of Momat, can cause irritation at the site of application. In such cases, stop using the drug and prescribe appropriate treatment.

It should be borne in mind that corticosteroids can change the manifestations of some skin diseases, making it difficult to make a diagnosis. In addition, the use of corticosteroids can cause delayed wound healing.

With prolonged therapy with corticosteroids, a sudden cessation of therapy can lead to the development of rebound syndrome, which manifests itself in the form of dermatitis with intense reddening of the skin and a burning sensation. Therefore, after a long course of treatment, the drug should be discontinued gradually, for example, switching to an intermittent treatment regimen before completely stopping it.

Pediatric use

Due to the fact that in children the ratio of surface area and body weight is greater than in adults, children are at greater risk of suppression of the function of the hypothalamic-pituitary-adrenal system and the development of Cushing's syndrome with external use of corticosteroids. Long-term treatment of children with corticosteroids can lead to impaired growth and development. Children should receive the minimum dose of the drug, sufficient to reduce the effect.

Terms of dispensing from pharmacies

The drug is dispensed by prescription.

Registration numbers

. cream for external approx. 0.1%: tube 5 g or 15 g LSR-005537/07 (2028-12-07 - 0000-00-00)
. ointment for external approx. 0.1%: tube 5 or 15 g LSR-005532/07 (2028-12-07 - 0000-00-00) Total analogues: 49. Price and availability of Momat Rino analogues in pharmacies. Before using any medication, you should definitely consult your doctor.

This page provides a list analogues Momat Rino- these are interchangeable drugs that have similar indications for use and belong to the same pharmacological group. Before you buy analog Momat Rino, it is necessary to consult with a specialist regarding the replacement of the drug, study in detail, read and a similar drug.

• Zodak

  A drug Zodak shown at:
  - Therapy of itching and urticaria of various origins, including urticaria accompanied by fever (chronic idiopathic urticaria);
  - symptomatic therapy of allergic seasonal rhinitis and year-round allergic rhinitis;
  - symptomatic therapy of allergic conjunctivitis.

• Psilo Balm

  - sunburns and burns of the 1st degree;
  - insect bites;
  - urticaria;
  - skin itching of various origins;
  - itchy eczema;
  - chickenpox;
  - allergic skin reactions (with the exception of itching with cholestasis);
  - contact dermatitis caused by contact with plants.

• Claritin

  A drug Claritin prescribed for:
  - seasonal (hay fever) and year-round allergic rhinitis and allergic conjunctivitis (to eliminate the symptoms associated with these diseases - sneezing, itching of the nasal mucosa, rhinorrhea, burning sensation and itching in the eyes, lacrimation);
  - chronic idiopathic urticaria;
  - skin diseases of allergic origin.

• Eden

  For the rapid elimination of allergic symptoms, including pollinosis and allergic rhinitis (such as sneezing, nasal discharge, itching, swelling and nasal congestion, as well as itching in the eyes, watery eyes and redness of the eyes, itching in the palate and coughing); to eliminate symptoms associated with chronic idiopathic urticaria (such as itching, rashes).
  

• Allergo-Norm

  Prevention and complex treatment of acute and chronic infectious and inflammatory diseases of the nasal cavity, paranasal sinuses and nasopharynx, such as:
  - acute and chronic rhinitis (runny nose);
  - SARS and influenza;
  - sinusitis and other sinusitis;
  - adenoiditis;
  allergic and vasomotor rhinitis;
  restoration of the mucosa and prevention of complications after undergoing surgical interventions in the nasal cavity and paranasal sinuses;
  preparation of the nasal mucosa for the application of drugs;
  daily hygiene of the nasal cavity;
  increased dryness of the nasal mucosa;
  harmful effects on the mucous membrane of the upper respiratory tract: smoking, work in hazardous industries, being in rooms with air conditioning or central heating turned on, in regions with unfavorable environmental or special climatic conditions.
  

• Fluorocort

  A drug Fluorocort is used to treat patients with skin diseases of various etiologies, excluding diseases of infectious etiology (including viral, bacterial and fungal skin lesions), in particular, the drug is indicated for such diseases: acute and chronic eczema, itching in the genital area and anus, contact dermatitis of various origins, neurodermatitis (atopic dermatitis), Duhring's hypertiform dermatitis, dermatitis of the external auditory canal, lichen planus and discoid lupus erythematosus, versicolor versicolor, pemphigus vulgaris, psoriasis, balanitis, pink pityriasis, granuloma annulare.
  In addition, the drug is used to treat patients suffering from urticaria, photosensitivity, polymorphic exudative erythema of various etiologies.
  The drug is used to reduce unpleasant symptoms (including itching and burning) and for the speedy healing of skin lesions after insect bites and sunburn.
  There is evidence of the use of the drug in Leiner's disease.
  

• Nasonex

  Nasonex used to treat allergic rhinitis (seasonal and year-round) in adults, adolescents and children from 2 years of age; exacerbation of sinusitis (complex therapy with antibiotics) in adults (including senile age) and children from 12 years of age; prevention of seasonal allergic rhinitis of moderate and severe course (recommended 2-4 weeks before the expected start of the dusting season).
  

• Suprastin

  Suprastin are: allergic diseases (including urticaria, serum sickness, pollinosis, or hay fever, rhinitis, conjunctivitis); anaphylactic shock and angioedema; skin diseases (including contact dermatitis, acute and chronic eczema, neurodermatitis, toxicoderma); prevention and treatment of allergic and pseudo-allergic reactions to drugs and diagnostic drugs; itching and insect bites; SARS.
  

• Parlazin

  Indications for the use of the drug Parlazin are: seasonal and year-round allergic rhinitis and conjunctivitis, itchy allergic dermatoses, pollinosis (hay fever), urticaria (including chronic idiopathic), Quincke's edema.
  

• Knoxprey

  Indications for the use of the spray Knoxprey are: acute rhinitis of allergic or infectious-inflammatory etiology, sinusitis, nasal congestion and difficulty in nasal breathing with colds, eustachitis, otitis media.
  To facilitate rhinoscopy and other manipulations in the nasal cavity.
  

• Zilola

  A drug Zilola used for the symptomatic treatment of allergic rhinitis, including year-round allergic rhinitis; chronic idiopathic urticaria.
  

• Erides

  A drug Erides designed to quickly relieve allergic symptoms and allergic rhinitis (such as sneezing, nasal discharge, itching, swelling and nasal congestion, as well as itching, tearing and redness of the eyes, itchy palate and cough)
  to eliminate symptoms associated with hives, itching and rashes.
  

• Blogir-3

  Indications for the use of the drug Blogir-3 are: allergic rhinitis (elimination or relief of sneezing, nasal congestion, discharge of mucus from the nose, itching in the nose, itching of the palate, itching and redness of the eyes, watery eyes); urticaria (reduction or elimination of skin itching, rash).
  

• Lorano

  A drug Lorano is intended for the symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria.
  

• AFRIN MOISTURIZING

  Spray Afrin Moisturizing used for symptomatic treatment of rhinitis (rhinitis) of allergic and / or infectious-inflammatory etiology; sinusitis; eustachitis; hay fever.

• Rinosol-Forte

  Indications for the use of the drug Rinosol-Forte are: rhinitis, sinusitis and sinusitis of infectious and inflammatory origin, incl. with associated allergic manifestations
  

• Clarotadine

  Indications for the use of the drug Clarotadine are: seasonal and year-round rhinitis (including hay fever), allergic conjunctivitis, urticaria (including chronic idiopathic), Quincke's edema, pseudo-allergic reactions caused by the release of histamine; itchy dermatoses; allergic reaction to insect bites.
  

• Sanorin-Analergin

  Drops Sanorin-Analergin are used to treat acute rhinitis, especially allergic etiology, rhinorrhea, hay fever.
  

• Sertospan

  A drug Sertospan is used to treat conditions and diseases in which corticosteroid therapy allows to achieve an adequate clinical effect (it should be borne in mind that in some diseases corticosteroid therapy is additional and does not replace standard therapy):
  - diseases of the musculoskeletal system and soft tissues, incl. rheumatoid arthritis, osteoarthritis, bursitis, ankylosing spondylitis, epicondylitis, radiculitis, coccygodynia, sciatica, lumbago, torticollis, ganglion cyst, exostosis, fasciitis, foot diseases;
  - allergic diseases, incl. bronchial asthma, hay fever (pollinosis), allergic bronchitis, seasonal or year-round rhinitis, drug allergy, serum sickness, reactions to insect bites;
  - dermatological diseases, incl. atopic dermatitis, nummular eczema, neurodermatitis, contact dermatitis, severe photodermatitis, urticaria, lichen planus, insulin lipodystrophy, alopecia areata, discoid lupus erythematosus, psoriasis, keloid scars, pemphigus vulgaris, dermatitis herpes, cystic acne;
  - systemic connective tissue diseases, including systemic lupus erythematosus, scleroderma, dermatomyositis, periarteritis nodosa;
  - hemoblastosis (palliative therapy for leukemia and lymphomas in adults, acute leukemia in children);
  - primary or secondary insufficiency of the adrenal cortex (with the mandatory simultaneous use of mineralocorticoids);
  - other diseases and pathological conditions requiring therapy with systemic corticosteroids (adrenogenital syndrome, ulcerative colitis, regional ileitis, malabsorption syndrome, lesions of the eye mucosa if it is necessary to administer the drug into the conjunctival sac, pathological changes in the blood if it is necessary to use corticosteroids, nephritis, nephrotic syndrome).
  

• Eslotin

  Indications for the use of the drug Eslotin are:
  - seasonal pollinosis and year-round allergic rhinitis (elimination or relief of sneezing, discharge of mucus from the nose, itching and nasal congestion, itching and redness of the eyes, lacrimation, itching of the palate);
  - chronic idiopathic urticaria (reduction and elimination of skin itching and rash).
  

• Nazaxil

  Indications for the use of the drug Nazaxil are: acute respiratory diseases, with rhinitis; vasomotor rhinitis; sinusitis; otitis media (to reduce swelling of the nasopharyngeal mucosa); preparation of the patient for diagnostic manipulations in the nasal passages.
  

• Elzet

  Elzet is intended for the treatment of such symptoms of year-round (persistent) and seasonal (intermittent) allergic rhinitis and allergic conjunctivitis as itching, sneezing, nasal congestion, rhinorrhea, lacrimation, conjunctival hyperemia; pollinosis (hay fever); urticaria, incl. chronic idiopathic urticaria, angioedema; other allergic dermatoses, accompanied by itching and rashes.
  

• Galazolin

  Indications for the use of the drug Galazolin are: acute rhinitis of viral or bacterial origin; allergic rhinitis; acute sinusitis; chronic sinusitis in the acute phase; hay fever; otitis media (in order to reduce swelling of the mucous membrane of the nasopharynx and restore the patency of the Eustachian tube).
  

• Kenalog

  Kenalog used in systemic treatment:
  - As a short-term adjunctive therapy for posttraumatic osteoarthritis, synovitis, osteoarthritis, rheumatoid arthritis, acute and subacute bursitis, epicondylitis, acute nonspecific tenosynovitis, acute attacks of gout, psoriatic arthritis, ankylosing spondylitis, juvenile rheumatoid arthritis;
  - With exacerbations or as maintenance therapy for systemic lupus erythematosus, acute rheumatoid carditis;
  - Pemphigoid, severe erythema multiforme (Stevens-Jones syndrome), exfoliative dermatitis, severe psoriasis
  - Severe allergic diseases: allergic rhinitis, bronchial asthma, angioedema, contact dermatitis, atopic dermatitis, allergic reactions to drugs and serums, insect bites;
  - Severe chronic allergic and inflammatory diseases of the organs of vision: herpes, iritis, iridocyclitis, chorioretinitis, diffuse, posterior uveitis, optic neuritis, sympathetic ophthalmia, inflammation of the anterior segment;
  - Diseases of the respiratory organs: symptomatic sarcoidosis, berylliosis, aspiration pneumonia;
  - Hematological diseases: acquired autoimmune anemia;
  - Oncological diseases: palliative treatment of leukemia and leukemia in adults; acute leukemia in children;
  - For edema: to increase diuresis and treat proteinuria in nephrotic idiopathic syndrome without uremia or nephrotic syndrome due to systemic lupus erythematosus.
  Local drug treatment Kenalog. Intra-articular or periarticular and vaginal tendon insertion as an additional short-term therapy for synovitis, osteoarthritis, rheumatoid arthritis, acute and subacute bursitis, acute attacks of gout, epicondylitis, acute non-specific tenosynovitis, post-traumatic osteoarthritis.
  

• Oxinazine

  Indications for the use of the drug Oxinazine are: rhinitis (including infectious-inflammatory, allergic etiology), sinusitis, diagnostic vasoconstriction.
  

• Nafazoline

• Alerdez

• Eloran

• GLENSPRAY WITH AZELASTINE

• HYDROCORTISONE

• CELESTODERM-V WITH GARAMICIN

• ALLERGOVAL

• MILT

• ZODAK EXPRESS

• Nazivin

  Nazivin is intended for the treatment of acute rhinitis (including allergic), vasomotor rhinitis, paranasal sinusitis, eustachitis, otitis media. Narrowing of the vessels of the mucous membrane for diagnostic purposes (under medical supervision).
  

• Gistan

  A drug Gistan Helps relieve allergy symptoms.
  

• Feksadin

  Indications for the use of the drug Feksadin are:
  - Seasonal allergic rhinitis: sneezing, itching, rhinitis, redness of the eyes and other symptoms of hay fever - tablets, 120 mg;
  - Chronic idiopathic urticaria: redness, itching and other symptoms of urticaria - tablets, 180 mg.
  

• cetirizine

• Ezlor

  Indications for the use of the drug Ezlor are:
  - allergic rhinitis (elimination or relief of sneezing, nasal congestion, discharge of mucus from the nose, itching in the nose, itching of the palate, itching and redness of the eyes, watery eyes);
  - urticaria (reduction or elimination of skin itching, rash).
  

• Loratadin-Teva

  A drug Loratadin-Teva used for the symptomatic treatment of seasonal and perennial allergic rhinitis; chronic idiopathic urticaria.
  

• Flosteron

  A drug Flosteron wide range of applications:
  - Dermatological diseases: atopic dermatitis (monetary eczema), neurodermatitis, contact dermatitis, severe solar dermatitis, urticaria, lichen planus, insulin lipodystrophy, alopecia areata, discoid lupus erythematosus, psoriasis, keloid scars, common pemphigus, dermatitis herpes, cystic acne.
  - Rheumatic diseases: rheumatoid arthritis, osteoarthritis, bursitis, tendosynovitis, tendonitis, peritendinitis, ankylosing spondylitis, epicondylitis, sciatica, coccydynia, sciatica, lumbago, torticollis, ganglion cyst, exostoses, fasciitis, acute gouty arthritis, synovial cysts, Morton's disease, inflammation cuboid bone, diseases of the feet, bursitis against the background of hard callus, spurs, stiffness of the big toe.
  - Allergic conditions: bronchial asthma, status asthmaticus, hay fever, severe allergic bronchitis, seasonal and aperiodic allergic rhinitis, angioedema, contact dermatitis, atopic dermatitis, serum sickness, hypersensitivity reactions to drugs or insect bites.
  - Collagen diseases: systemic lupus erythematosus, scleroderma, dermatomyositis, periarteritis nodosa.
  - Oncological diseases: palliative therapy for leukemia and lymphomas in adults, acute leukemia in children.
  - Other diseases: adrenogenital syndrome, ulcerative colitis, Crohn's disease, sprue, pathological blood changes requiring corticosteroid therapy, nephritis, nephrotic syndrome.
  - Primary and secondary insufficiency of the adrenal cortex (with the mandatory simultaneous administration of mineralocorticoids).
  

• Allergorus

  Indication for use Allergorus is an:
  - Allergic rhinitis (seasonal or year-round);
  - Vasomotor rhinitis.
  

• Rolinoz

  Indications for the use of the drug Rolinoz are:
  - year-round and seasonal allergic rhinitis (as a symptomatic therapy);
  - pollinosis;
  - urticaria (including chronic idiopathic);
  - dermatoses that occur with itching (including atopic dermatitis, neurodermatitis);
  - allergic conjunctivitis;
  - chronic eczema;
  - bronchial asthma as part of complex therapy.

• Diprospan

  Indications for the use of the drug Diprospan are: rheumatoid arthritis; osteoarthritis, bursitis, tendosynovitis, tendinitis, peritendinitis, ankylosing spondylitis, epicondylitis, sciatica, coccydynia, sciatica, lumbago, torticollis; exostosis, fasciitis, disease of the feet, bursitis against the background of hard callus, spurs, stiffness of the big toe; ganglion cyst; bronchial asthma, status asthmaticus, hay fever, allergic bronchitis, allergic rhinitis, drug allergy, serum sickness; reactions to insect bites; atopic dermatitis (monetary eczema), neurodermatitis, contact dermatitis, severe solar dermatitis, urticaria, lichen planus, insulin lipodystrophy, alopecia areata, discoid lupus erythematosus, psoriasis, keloid scars, common pemphigus, herpetic dermatitis, cystic acne; systemic lupus erythematosus, scleroderma, dermatomyositis, periarteritis nodosa; palliative therapy for leukemia and lymphomas in adults, acute leukemia in children; adrenogenital syndrome; ulcerative colitis, regional ileitis, sprue; pathological changes in the blood, which require corticosteroid therapy; nephritis, nephrotic syndrome; primary and secondary insufficiency of the adrenal cortex (with the mandatory simultaneous administration of mineralocorticoids).

pharmachologic effect

Preparation for external use.

Mometasone is a synthetic GCS with anti-inflammatory, antipruritic and anti-exudative action. GCS induce the release of lipocortin proteins that inhibit phospholipase A2, which control the biosynthesis of inflammatory mediators (prostaglandins, leukotrienes) by inhibiting the release of their common precursor, arachidonic acid.

Pharmacokinetics

Suction

Absorption of ointment and cream Momat is negligible. 8 hours after a single application of the drug to intact skin (without an occlusive dressing), about 0.7% (ointment) and 0.4% (cream) of the active substance are found in the systemic circulation.

Metabolism

Mometasone is extensively metabolized in the liver.

breeding

It is excreted mainly by the kidneys and in small amounts with bile. T1 / 2 of mometasone from Momat ointment is approximately 5.8 hours.

Indications

Inflammation and itching in dermatoses (psoriasis, atopic dermatitis, seborrheic dermatitis) amenable to glucocorticosteroid therapy in adults and children over 2 years of age.

Dosing regimen

Outwardly. A thin layer of ointment or cream Momat is applied to the affected areas of the skin 1 time per day. The duration of the course of treatment is determined by its effectiveness, tolerability of the drug, as well as the presence and severity of side effects.

Side effect

From the endocrine system: when using external forms of corticosteroids for a long time and / or for treatment on large areas of the skin, or using occlusive dressings, especially in children and adolescents - adrenal insufficiency, Cushing's syndrome.

Dermatological reactions: rarely - skin irritation, dry skin, burning sensation, folliculitis, hypertrichosis, acne, hypopigmentation, perioral dermatitis, skin maceration, secondary infection, signs of skin atrophy, striae, prickly heat; less than 1% of cases - the formation of papules, pustules.

Allergic reactions: rarely - itching, allergic contact dermatitis.

Contraindications

• rosacea;
• perioral dermatitis;
• bacterial, viral (Herpes simplex, chicken pox, Herpes zoster) or fungal infections of the skin;
• tuberculosis, syphilis;
• post-vaccination reactions;
• children's age up to 2 years;
• pregnancy (use on large areas of the skin, long-term treatment);
• lactation period (use in high doses and / or for a long time);
• hypersensitivity to corticosteroids or to the components of the drug.

With caution, the drug should be applied to intertriginous skin and facial skin, used with occlusive dressings, on large areas of the skin and / or for a long period of time (especially in children).

Pregnancy and lactation

The safety of using mometasone furoate during pregnancy and lactation (breastfeeding) has not been established.

GCS penetrate the placental barrier. Long-term treatment and the use of high doses during pregnancy should be avoided due to the threat of negative effects on fetal development.

GCS are excreted in breast milk. In the case when the use of corticosteroids in large doses and / or for a long time is expected, breastfeeding should be stopped.

special instructions

When applying the drug to large areas of the skin for a long time, especially when using occlusive dressings, it is possible to develop signs of suppression of the function of the hypothalamic-pituitary-adrenal system and the development of Cushing's syndrome.

Avoid getting Momat ointment and cream on the mucous membrane of the eye.

Propylene glycol, which is part of Momat, can cause irritation at the site of application. In such cases, stop using the drug and prescribe appropriate treatment.

It should be borne in mind that corticosteroids can change the manifestations of some skin diseases, making it difficult to make a diagnosis. In addition, the use of corticosteroids can cause delayed wound healing.

With prolonged therapy with corticosteroids, a sudden cessation of therapy can lead to the development of rebound syndrome, which manifests itself in the form of dermatitis with intense reddening of the skin and a burning sensation. Therefore, after a long course of treatment, the drug should be discontinued gradually, for example, switching to an intermittent treatment regimen before completely stopping it.

Pediatric use

The safety and efficacy of topical mometasone furoate in children for periods longer than 6 weeks have not been studied. Due to the fact that in children the ratio of surface area and body weight is greater than in adults, children are at greater risk of suppression of the function of the hypothalamic-pituitary-adrenal system and the development of Cushing's syndrome with external use of corticosteroids. Long-term treatment of children with corticosteroids can lead to impaired growth and development. Children should receive the minimum dose of the drug, sufficient to reduce the effect.

Overdose

Symptoms: depression of the function of the hypothalamic-pituitary-adrenal system, including secondary adrenal insufficiency.

Treatment: symptomatic, if necessary, carry out a correction of the electrolyte balance, drug withdrawal (with long-term therapy - gradual withdrawal).

drug interaction

Studies of drug interactions of the ointment and cream Momat with other drugs have not been conducted.

Terms of dispensing from pharmacies

The drug is dispensed by prescription.

Terms and conditions of storage

The drug should be stored out of the reach of children, dry, dark place at a temperature not exceeding 25 ° C; do not freeze. Shelf life - 2 years.

Avamys and Nasonex are drugs intended for intranasal use. Both of these drugs are classified as synthetic glucocorticoids. There are general indications for the appointment of Avamys or Nasonex:

• allergic rhinitis,
• acute sinusitis,
• hay fever,
• sinusitis,
• adenoiditis,
• polyps in the nasal cavity.

Both drugs differ significantly in price: Nasonex is twice as expensive as Avamys. Despite the common mechanism of action, drugs are not interchangeable. Which is better - Avamys or Nasonex should be decided by the doctor in each specific situation. The choice of drug depends on the course of the disease, age and general condition of the patient.

Active substance

The active ingredient in Avamys is fluticasone furoate. Nasonex is based on mometasone furoate. Both of these compounds are corticosteroids.

Hormonal agents, as a rule, affect the entire body. Prolonged use of glucocorticoids leads to a decrease in the synthesis of corticotropic hormone by the adenohypophysis. A drop in the level of corticotropin causes a decrease in the synthesis of hormones by the adrenal cortex. There is a need for constant intake of exogenous glucocorticoids. The difference between Avamis and Nasonex drugs from systemic drugs is that they are intended for topical use. Drugs enter the bloodstream in such small quantities that their concentration cannot be determined by a laboratory blood test. The risk of side effects is minimized.

The drugs inhibit the metabolism of arachidonic acid, inhibit the release of pro-inflammatory tissue mediators, and reduce tissue swelling. The migration of lymphocytes to the focus of inflammation is slowed down. The effects produced by the substances are so similar that it is difficult for many non-specialists to understand what is the difference between Avamys and Nasonex.

The drug Nasonex is weaker than Avamys. The concentration of the active substance in it is lower. In addition, fluticasone furoate has a stronger effect on body tissues than mometasone furoate. Nasonex, as a more gentle remedy, can be used for prevention. For example, people suffering from pollinosis are advised to start taking the medicine two weeks before the flowering of plants that cause allergies.

How to use medicines correctly

Both Avamys and Nasonex are sprays. The bottles are equipped with convenient dispensers. Before inhalation, the container with the drug should be shaken.

For treatment, adults and adolescents over 12 years of age are prescribed Nasonex, one inhalation in each nostril 2 times a day. The maximum allowable dose is twice the recommended one and is two inhalations 2 times a day. If after a few days the patient's condition improves, the number of injections of the drug is reduced. Children from 2 to 12 years old take one inhalation once a day.

Avamys is taken once a day. The initial dose is 2 inhalations, the maintenance dose after achieving a positive result is 1 spray in each nostril.

Medicines should be stored at a temperature not exceeding 25 0 C. They must not be frozen - at low temperatures, the active substances of the drugs are destroyed, they lose their properties.

Drug metabolism

Both Avamys and Nasonex, entering the bloodstream, form complexes with plasma proteins. BUT The active substances of the drugs are bound and excreted by the liver. Accidental ingestion of one of the drugs into the esophagus during intranasal administration does not lead to significant consequences - both active substances are poorly absorbed by the walls of the gastrointestinal tract and are almost completely excreted with feces.

No more than 2% of metabolites are excreted in the urine. It is allowed to prescribe drugs to people suffering from kidney and liver diseases of moderate severity. For more serious pathologies, the medicine can be used only after consulting with your doctor.

Contraindications for the drug Nasonex

Absolute contraindications for the appointment of a spray are intolerance to the components of the drug and children under 2 years of age. If a child is diagnosed with acute sinusitis or a chronic disease has worsened, the medicine is used from the age of 12. With polyposis, it is recommended to use the drug from the age of 18. Also, Nasonex should not be used in the following cases:

• if the patient has recently undergone sinus surgery;
• with viral, bacterial or fungal diseases;
• when the upper respiratory tract and eyes are affected by the herpes simplex virus;
• with tuberculosis of the respiratory system.

For liver diseases, Avamys spray is more preferable. Both drugs should not be given concomitantly with other corticosteroids, as the liver may not be able to handle large amounts of the drug.

Avamys contraindications

Avamys has fewer contraindications than Nasonex. Among them are hypersensitivity to the components of the drug, severe violations of the liver, the simultaneous use of the drug Ritonavir. Until 6 years of age, it is better to prescribe the drug to a child with caution.

Appointment during pregnancy and lactation

Thorough clinical studies on the effect of Avamys and Nasonex on the fetus during pregnancy have not been conducted. According to the recommendations of doctors and pharmacists, the use of topical glucocorticosteroids is allowed in cases where the benefit to the mother significantly outweighs the possible risk to the fetus. There is also no data on whether fluticasone furoate and mometasone furoate enter breast milk when administered intranasally.

Pregnant women are more often prescribed Avamys. The use of the drug by the mother is the basis for examining the endocrine system of the child - the intake of exogenous corticosteroids can provoke hypofunction of the adrenal glands.

The choice of drug for adenoiditis

According to Dr. Komarovsky, Avamys or Nasonex for adenoids is best combined with antihistamines. The use of local drugs helps to alleviate the symptoms of the disease and make life easier for the patient, but these drugs do not eliminate the cause of adenoiditis. With inflammation of the pharyngeal tonsil of an infectious nature, Avamys and Nasonex will be ineffective. Therapeutic treatment is considered appropriate for adenoiditis of the first and second degree.

With sinusitis or adenoids, children are more often prescribed Nasonex than Avamys. The drug gradually reduces inflammation without overdrying the nasal mucosa. Do not use Nasonex simultaneously with vasoconstrictors. Its long-term use does not cause dependence, but suppresses the local immune response. After discontinuation of the drug, adenoiditis may resume.

Side effects

Side effects of Avamys and Nasonex on the human body are quite similar and occur with the same frequency. The most dangerous is the development of immediate-type hypersensitivity reactions, such as:

• anaphylactic shock;
• angioedema;
• bronchospasm;
• hives;
• hyperemia of the skin;
• irritation of mucous membranes;
• itching and burning.

In such cases, it is necessary to immediately stop treatment and consult an allergist. Other side effects are headache, nosebleeds, bad taste in the mouth, and ulceration of the mucous membranes. In rare cases, intraocular pressure increases and there are signs of perforation of the nasal septum.

When using drugs Avamys and Nasonex in therapeutic doses, pathological reactions of the body occur no more often than when taking a placebo. The likelihood of side effects increases with overdose and use of the drug by children under 2 years of age.

Avamys and Nasonex are hormonal preparations based on glucocorticosteroids. The difference between them lies in the composition, concentration of the active substance, the number of contraindications and price. Both drugs do not have a systemic effect and enter the blood in small quantities. Pregnant women are more often prescribed Avamys, children under 12 years old - Nasonex. The choice of medicine in each case should be carried out by the attending physician.