To relieve the symptoms of redness in dermatitis or treat a fungus, Pimafucort cream, which belongs to the group of glucocorticosteroids (GCS), is used. It contains antibacterial substances that effectively eliminate itching, rashes on the skin. Can be used by children, pregnant women. Familiarize yourself with the rules for using a hormonal antibacterial agent to eliminate the risks of side effects.

Pimafucort cream - instructions for use

According to the pharmacological classification, Pimafucort belongs to the group of hormonal glucocorticoids. It comes in two formats - cream, ointment. Both products are characterized by a white opaque color with a creamy tint, thick consistency. The drug is intended for external local antibacterial use, has restrictions on the use specified in the instructions.

Compound

The active ingredients of Pimafucort cream are natamycin, antibiotic neomycin in sulfate format, micronized hydrocortisone. The ointment contains similar components. The composition of the products is indicated in the table:

Release form

Pimafukort is produced in the form of a cream, ointment. The first is a homogeneous white structure with a slight yellowish tint. Plastic or aluminum tube includes 15 g, packed in a cardboard box. The ointment of a uniform texture of white or with a yellow tint is also enclosed in a 15-gram tube made of plastic or aluminum, a pack of cardboard. Both tubes are equipped with a membrane and sealed with a screw cap.

pharmachologic effect

The combined composition of neomycin, natamycin, hydrocortisone makes Pimafucort a drug with antibacterial, antifungal, anti-inflammatory effects. The cream is used for external use. Neomycin sulfate has a broad antibacterial effect, destroys gram-negative bacteria, enterococci, staphylococci, Escherichia coli, Klebsiella, Proteus. Natamycin belongs to the group of macrolides, a subgroup of polyenes, and is effective against yeasts and dermatophytes. Hydrocortisone helps relieve itching, inflammation in dermatitis.

Antibiotics against dermatophytes, Fusarium have low adsorption to intact mucous membranes, but significantly increase the degree of absorption when applied to wounds and ulcers. Hydrocortisone is absorbed by intact skin in the amount of 1-3%, by damaged areas - twice as much, with infections - four times as much. Hydrocortisone has anti-inflammatory properties, in children it shows increased absorbability than in adults. The degree of absorption by the systemic circulation of the drug decreases with age.

Pimafucort - indications for use

According to the instructions for use of Pimafucort, the drug has an antibacterial effect and has the following indications for use:

• mycoses of the skin: otomycosis, superficial acute dermatoses, subacute dermatoses infected with pathogens;
• pyoderma, subacute or acute infectious dermatoses;
• thrush on the skin - in patients of children, men (it is forbidden to use ointment or cream inside), treatment of chronic forms of dermatosis, candidiasis;
• skin lesions by fungi or bacteria that are hypersensitive to antifungal effects and antibacterial components of the agent;
• weeping areas of the skin;
• local anti-inflammatory treatment of infections of the skin and subcutaneous tissue, superficial defects.

Method of application and dosage

In the treatment of subacute or acute dermatoses, a cream is prescribed. Pimafucort for thrush, especially chronic, requires an ointment form, similar to the treatment of chronic dermatoses. The drug can be used under an occlusive dressing for lichenification, dry skin, seborrhea, and other factors when pronounced occlusive properties of the ointment are needed. With thrush, the course of treatment with a cream is 14-30 days, although the first results, according to reviews, are already visible for 3-4 days. It is necessary to continue therapy according to the appointed time so that there are no relapses.

Apply an antifungal agent to the affected areas of the skin or mucous membranes for fungal skin diseases two to four times a day. Otomycosis requires the introduction of Pimafucort into the ear canal. The course of treatment with a drug that has an antibacterial effect is 0.5-1 month. You can treat them with children, adults, but the first is forbidden to apply the cream over a large area or use occlusive dressings with an increased risk of suppressing the function of the adrenal cortex.

special instructions

Instructions for use Pimafukort contains a section of special instructions. Here are some excerpts from it:

• against the background of the use of the cream, the development of fungi in excess or superinfection is possible - you can get rid of the termination of treatment, the connection of appropriate therapy;
• when applying Pimafucort under a bandage or over a large area, be aware of the possible inhibition of the production of adrenal hormones;
• you can not apply the cream on the eyes or eyelids - there is a high risk of developing cataracts, an increase in intraocular pressure;
• when used on wounds, ulcers for a long time, a nephrotoxic, ototoxic effect, exacerbation of the disease is possible, according to reviews;
• Pimafucort is prescribed with caution in diseases of the cranial nerves after taking aminoglycoside antibiotics, perforated tympanic membrane and systemic tuberculosis due to the risk of developing the ototoxic effect of neomycin

Pimafucort during pregnancy

Dermatologists do not limit the use of Pimafucort in any format to pregnant women and those who are breastfeeding a baby. It should be remembered that the manifestation of the ototoxic effect of neomycin is possible, therefore, during pregnancy and lactation, women are forbidden to apply it under occlusive dressings or on a large area of ​​the skin and mucous membranes.

In childhood

When children reach the age of one year, it is possible to use the drug, but only under strict indications and under medical supervision. The drug does not have a systemic effect, but it can be applied only to limited areas of the skin, without affecting the face and without using occlusive dressings. The duration of the course of treatment does not differ from the adult period.

drug interaction

According to the instructions for the use of Pimafucort, there is no data on the drug interaction of the drug with other medicines. Theoretically possible effects between neomycin and paromomycin, kanamycin, gentamicin. Doctors do not exclude cases of cross-sensitivity between aminoglycosides and neomycin, other antibiotics of this group.

Contraindications

The same annotation, enclosed in each pack of Pimafucort cream or ointment, says about the contraindications for the use of funds:

• age up to a year;
• allergic reactions or hypersensitivity to components;
• viral skin diseases (hydrocortisone has a negative effect);
• skin manifestations of syphilis;
• ulcerative lesions of the skin;
• rosacea;
• lupus;
• ichthyosis;
• anogenital itching;
• open wounds;
• acne disease;
• skin reactions after vaccination;
• tumors.

Side effects

In the first days of using the cream, a slight exacerbation of the disease is possible, which is temporary, as well as other side effects:

• withdrawal syndrome after discontinuation of use;
• stretch marks on the skin;
• perioral, rosacea-like dermatitis;
• skin thinning, atrophy;
• telangiectasia;
• purpura;
• contact dermatitis;
• depigmentation;
• hypertrichosis;
• increased production of hydrocortisone;
• itching, burning, redness, delayed wound healing.

Overdose

There is no information about an overdose of Pimafucort cream, because studies on this topic have not been conducted. Hypothetically, there is a risk of ototoxicity when applied to the area of ​​the ear canal in case of perforation of the tympanic membrane, plus deterioration in the functionality of the middle ear due to the direct effect of neomycin. If signs are found, a visit to a specialist is required.

Terms of sale and storage

Ointment Pimafukort is stored at a temperature of 15-25 degrees, cream - about 25 degrees. Both products are dispensed by prescription, stored out of the reach of children, protected from light. The shelf life of the ointment is five years, the cream is three years. Do not use medicines after their expiration date.

Pimafukort - analogues

The drug is produced by the Dutch company Astellas, it is expensive, but has substitutes. The following analogue of Pimafukort cream is distinguished, produced by different manufacturers, differing in prices:

• Posterizan - costs 100 rubles cheaper, produced by Germany.
• Lokoid lipocream and Lokoid - an analogue of the same factory, costs an order of magnitude cheaper.
• Hydrocortisone - a domestic company from Tatarstan produces and sells it at a price of less than 50 rubles.
• Cortef - a cheap analogue of Pimafucort, has an anti-inflammatory effect.

Pimafucort cream price

You can buy Pimafucort in an online pharmacy or in the usual department, having a prescription from a doctor in your hands. The cost depends on the level of pricing of the trade enterprise and the form of release of the drug. Approximate prices for the drug and its analogues in Moscow are listed below.

Pimafucort cream is a combined preparation with antifungal, antibacterial, anti-inflammatory action. It treats skin diseases of various etymologies with the presence of a secondary infection. The product is produced in the Netherlands in the form of a cream and ointment. Sold in tubes of 15 g. Available by prescription. Before treatment, it is necessary to consult a specialist.

The drug with a triple action includes 3 active components, each performs its functions. Together they provide fast, lasting results.

1. Natamycin. Broad-spectrum antifungal drug. It acts on the cells of pathological organisms, leads to death. Eliminates the focus of inflammation, prevents the spread of infection.
2. Neomycin. An antibiotic that affects the pathogenic microflora. Destroys bacteria, prevents the spread of infection, stops inflammatory processes.
3. Hydrocortisone. Synthetic hormone that suppresses allergic processes. It has an anti-inflammatory effect, soothing, vasoconstrictor. Removes redness, relieves swelling, removes itching, burning.

Auxiliary components:

Additional substances form the consistency of the product, ensure deep penetration of active ingredients into skin cells, create a protective barrier on the surface of the epidermis, and regulate water balance. As part of the ointment, auxiliary components are wax and paraffin. The thick consistency stays on the surface of the skin longer, is absorbed more slowly, but lasts longer.

Cream action

Pimafucort is a strong hormonal drug that quickly eliminates the unpleasant symptoms of allergies, dermatitis, blocks the action of allergens, and restores the cover. Hydrocortisone is a synthetic adrenal hormone. It helps to cope with allergens, activates recovery processes, promotes renewal of the upper layer of the epidermis. Without hydrocortisone, it is impossible to achieve such a quick result in the presence of allergens in the blood.

The addition of a secondary infection allows pathological microorganisms to develop, provoking new unpleasant, dangerous symptoms. Moisture, cracks, blood discharge, seals appear on the skin. All this is accompanied by severe itching, which especially worse at night.

It is impossible to use corticosteroid agents in this case, since they provoke the growth of pathogenic microorganisms - fungi, bacteria, complicate the course of the disease. You need a strong antibiotic that can stop the reproduction of disease-causing cells. There are 2 such substances in Pimafukort - neomycin, natamycin.

After contact with the skin, the active ingredients are absorbed by the tissues, partially enter the bloodstream. They are localized in the places of foci of infection, the therapeutic effect begins 20 minutes after applying the cream. Metabolism takes place in the liver. Excreted from the body by the kidneys, through the intestines.

Indications

The drug of combined action should be used only in the presence of a secondary infection. Do not use in the acute stage of allergic manifestations. Pimafukort is used for:

Treatment should be started only after consultation with a specialist.

Contraindications

Pimafucort contains several active substances at once. Each of them has its own contraindications. All aspects must be taken into account, since the incorrect use of a strong drug leads to complex side effects.

It is worth refusing to use when:

Do not use for children under the age of 1 year, pregnant, lactating.

Instructions for use

The cream is applied to previously cleansed skin. Problem areas are treated with a thin layer. There is no need to rub hard, since the active ingredients are well absorbed. The procedure is done 2-4 times a day, depending on the complexity of the lesion of the epidermis. The course of therapy is set by the doctor. Treatment lasts from 14 to 30 days in adults, no more than 12 days in children.

Application Features:

You can not abruptly cancel the drug. Such actions lead to a rapid exacerbation of dermatitis. It is necessary to mix the drug with a regular moisturizer, gradually reducing the concentration of the drug. After a week, continue to use the moisturizer without Pimafukort. The scheme will help overcome the effect of addiction, increase the immunity of the skin, and quickly restore the skin.

Overdose, side effects

Before starting therapy, it is recommended to test for an allergic reaction in order to avoid trouble. A small amount of cream is applied to the elbow bend, the condition of the skin and well-being are monitored for 3 hours. The appearance of redness, itching, burning, and other unpleasant symptoms is the basis for refusing to use Pimafucort cream.

Cases of overdose occur in cases where the drug is used longer than the specified period.

• A large amount of hydrocortisone enters the bloodstream, which disrupts the work of the adrenal glands. The hormonal background is changing. This leads to amenorrhea, menstrual irregularities, skin rashes, oral dermatitis, which is much more difficult to get rid of.
• Prolonged use of a hormonal cream deforms, thins the skin, weakens local immunity. Dark spots and seals appear on the upper layer of the epidermis.
• The use of antibiotics for more than the specified period causes the growth of pathogenic microorganisms. Together with the long-awaited therapeutic effect, an exacerbation occurs. The action of antibiotics affects the functioning of the liver, gastrointestinal tract.

Side effects appear as:

If you follow the instructions for use, strictly observe the dosage, take into account all the nuances of proper use, no side effects occur. The therapeutic effect occurs quickly, lasts a long time, the disappearance of disturbing symptoms occurs within 7 days.

Pimafukort price

A pharmaceutical preparation can be bought at a pharmacy, ordered via the Internet. The average price for a cream or ointment in a volume of 15 g is 500 rubles. Released strictly according to the recipe. Shelf life - 3 years from the date of manufacture. Do not use the product after the expiration date.

What is the difference between Pimafucort cream and ointment

The composition of the active ingredients, the concentration is no different. They work equally well. The difference in complement lny components that affect the rate of absorption.

The ointment in its composition contains only active substances, wax, paraffin. The thick consistency allows the product to stay on the skin longer. Active components enter the tissues more slowly, the therapeutic effect is prolonged. It is recommended to use the ointment for adults, with severe damage to the skin, under bandages.

The cream, due to its light texture, is absorbed much faster. The therapeutic effect occurs instantly, but lasts less, it is necessary to apply not twice a day, like an ointment, but 3-4. Suitable for children's skin, face, it works better in the acute form of dermatosis.

Analogues

The drug Pimafucort is a unique tool. There are no direct analogues. The pharmacy can offer combined drugs with anti-inflammatory, antimicrobial, antifungal action based on other active substances. They include glucocorticosteroids, antibiotics, antifungal components.

• Dex-Gentamicin;
• Oxycort;
• Flucinar;
• Akriderm;
• Candiderm;
• Triderm.

Replacing Pimafucort with another external agent should be discussed with your doctor.

pharmachologic effect

A combined drug that has an antibacterial, antifungal and local anti-inflammatory effect due to the components that make up its composition.

Natamycin belongs to the polyene antibiotics of the macrolide group, has a fungicidal effect. Active towards yeast and yeast-like fungi (especially Candida spp.). Dermatomycetes are less sensitive to natamycin.

Neomycin is a broad-spectrum antibiotic from the group of aminoglycosides, active against gram-positive bacteria: Staphylococcus spp., Enterococcus spp.; Gram-negative bacteria: Klebsiella spp., Proteus spp., Escherichia coli and others.

Hydrocortisone has anti-inflammatory and vasoconstrictive effects. Eliminates inflammation and itching that accompanies various types of dermatoses.

Pharmacokinetics

Natamycin and neomycin are practically not absorbed through intact skin and mucous membranes. Absorption of neomycin through damaged skin is possible, when applied to extensive wound and burn surfaces.

Through intact skin, 1 to 3% of hydrocortisone is absorbed; with dermatitis, the amount of absorbed hydrocortisone increases by 2 times, with infectious skin lesions it can increase by 5 times.

In children, the absorption of hydrocortisone through intact skin is higher than in adults. The degree of absorption of the drug into the systemic circulation decreases with age.

Indications

- dermatosis amenable to GCS therapy, complicated by a secondary bacterial and / or fungal infection (especially caused by Candida spp.).

Dosing regimen

Adults and children the drug is applied to the affected areas of the skin 2-4 times / day. children

The duration of treatment is determined individually, taking into account the nature of the disease, the course of treatment usually does not exceed 14 days. If there is no improvement in the condition of children and adults after 14 days, you should consult a doctor.

The drug in the form of an ointment is intended for therapy subacute and chronic dermatoses, especially in the presence of severe dry skin, lichenification, or in cases where the occlusive properties of the ointment are necessary.

Side effect

Side effects with external use of Pimafucort develop rarely and are reversible.

Allergic reactions: rarely - itching, burning, redness or dryness of the skin.

Dermatological reactions: extremely rarely - atrophy and thinning of the skin, telangiectasia, striae, purpura, rosacea-like and perioral dermatitis, delayed wound healing, depigmentation, hypertrichosis, withdrawal syndrome after stopping treatment; contact dermatitis to neomycin.

System reactions: with external use of corticosteroids for a long time on large areas of the skin, or when using occlusive dressings, especially in children, side effects may develop due to the systemic action of corticosteroids - symptoms of suppression of the function of the adrenal cortex.

Contraindications for use

- tuberculosis of the skin;

- skin manifestations of syphilis;

- viral infections of the skin;

- skin post-vaccination reactions;

- open wounds;

- ulcerative lesions of the skin;

- acne disease;

- rosacea;

- ichthyosis;

- anogenital itching;

- skin tumors;

- Hypersensitivity to the components of the drug.

WITH caution the drug should be used for systemic tuberculosis, in patients with a history of damage to the IX pair of craniocerebral insufficiency against the background of the use of aminoglycosides. In the presence of perforation of the tympanic membrane and direct exposure of neomycin to the middle ear, there is a risk of ototoxicity.

Use during pregnancy and lactation

When using Pimafucort during pregnancy, it is necessary to take into account the theoretical risk of the ototoxic effect of neomycin, and therefore the drug should not be applied to large areas of the skin surface, the drug should not be used for a long time, it should not be used under occlusive dressings.

Use in children

With caution, the drug should be prescribed to children under the age of 1 year.

For children, the drug should be applied to limited areas of the skin and do not use occlusive dressings.

Overdose

There is no information about drug overdose. There is a theoretical possibility of an ototoxic effect of neomycin in the case of application of the drug to the ear canal in the presence of perforation of the tympanic membrane and direct exposure of neomycin to the middle ear.

drug interaction

The drug interaction of the drug Pimafucort ® is not described.

Possible cross-hypersensitivity between neomycin and drugs of similar chemical structure, such as kanamycin, paromomycin, gentamicin and cross-resistance between neomycin and other antibiotics of the aminoglycoside group.

Terms of dispensing from pharmacies

The drug is approved for use as a means of OTC.

Terms and conditions of storage

The drug should be stored out of the reach of children at a temperature not exceeding 25°C. The shelf life of the cream is 3 years. The shelf life of the ointment is 5 years.

special instructions

When applying Pimafucort to the eyelids and periorbital region, there is a risk of an increase in intraocular pressure, the development of cataracts.

In the case of prolonged treatment, in the presence of wounds and ulcers, there is a theoretical risk of ototoxic and nephrotoxic effects of neomycin.

If superinfection or excessive development of fungal microflora occurs, the use of the drug should be discontinued and appropriate measures taken.

Pediatric use

The drug should be administered with caution children under the age of 1 year.

In children, the drug should be used under medical supervision. When using the drug on large surfaces or under occlusive dressings, it is necessary to keep in mind the possibility of suppressing the function of the hypothalamic-pituitary-adrenal system.

Pimafucort is a drug intended for external use. Available in the form of an ointment. Its main components are an antibiotic and an anti-fungal agent. In addition, the composition contains hydrocortisone. The main function of the ointment is the fight against inflammatory processes, fungi and bacteria. Pimafucort is often prescribed for the treatment of dermatological diseases. However, its price (from 600 rubles for 15 g) is quite high. This article will discuss cheaper analogues of pimafucort.

List of cheap analogues of Pimafukort, price

Ointment indications: simple dermatitis, eczema, candidiasis, lichen.

Contraindicated in patients with skin tuberculosis, syphilis, chicken pox, herpes, children under 2 years of age. It is not recommended to use the ointment for pregnant women, as well as long-term treatment.

When applied, such effects as itching, burning, swelling, dry skin are extremely rare.

Oxycort. 400 rubles.

Ointment with anti-inflammatory, anti-allergic effect.

Oxycort is prescribed for streptococcus, staphylococcus, boils, abscesses on the skin, dermatitis, diaper rash, urticaria, insect bites.

Contraindicated in hypersensitivity, herpes, chickenpox, skin tuberculosis.

Side effects: irritation may occur at the site of application of the drug. It may appear as an allergic reaction.

Polcortolon. From 400 rubles.

This drug can cure dermatitis, pruritus, eczema, strophulus, as well as insect bites.

The ointment is contraindicated for perioral dermatitis, acne and trophic ulcers, as well as for children under 2 years of age.

Side effects when using the ointment: itching, burning, bruising.

Flucinar. From 200 rubles.

The ointment is used against dermatitis, urticaria, eczema, psoriasis, pruritus, the effects of insect bites, and burns.

The ointment can not be used for viral and fungal skin infections, syphilis, skin tuberculosis. In addition, flucinar is contraindicated for pregnant and lactating women.

Side effects when using the ointment can manifest itself in itching of the skin and its irritation - rash and urticaria.

Akriderm. From 100 rubles.

The ointment is indicated for allergic diseases of the skin, all types of dermatitis, psoriasis.

You can not use the ointment for diseases such as: skin tuberculosis, skin viral infections, rosacea, as well as sensitivity to the components of the ointment.

Side effects can be manifested in irritation, dryness, burning of the skin.

Nystatin. 90 rubles.

This antibiotic in the form of an ointment effectively copes with fungi of the mucous membranes and skin.

In the form of side effects, nystatin can cause an allergic reaction - itching, hives, rash.

Hyoxysone. 70 rubles.

It helps well with all types of dermatitis, eczema, psoriasis, burns and insect bites.

Do not use the ointment for hypersensitive, with viral skin diseases, pregnant and lactating mothers, as well as children under 12 years of age.

Side effects can be skin irritation, rash, itching.

Cortomycetin. 50 rubles.

This ointment is able to cope with inflammation of the skin, allergic diseases, microbial infections and dermatitis.

It is forbidden to use cortomycetin for viral skin infections: chicken pox, herpes. Also, do not apply ointment to warts.

Side effects are extremely rare. They can be dryness, depigmentation of the skin, eczema.

Thus, we can conclude that there are a number of pharmaceutical companies that produce ointments similar to pimafucort. They are identical in quality, but are slightly cheaper.