In this medical article you can familiarize yourself with the drug Lasix. The instructions for use will explain at what pressure these injections or tablets can be taken, what the medicine helps with, what are the indications for use, contraindications and side effects. The annotation presents the forms of release of the drug and its composition.

In the article, doctors and consumers can only leave real reviews about Lasix, from which you can find out whether the medicine helped in the treatment of edema syndrome and hypertensive crisis in adults and children, for which it is still prescribed. The instructions list analogues of Lasix, prices of the drug in pharmacies, as well as its use during pregnancy.

Lasix is ​​a fast-acting diuretic drug. Instructions for use indicate that 40 mg tablets, injections in ampoules for intramuscular and intravenous injections dilate blood vessels and reduce blood pressure.

Release form and composition

Lasix is ​​available in tablet form and as a solution.

The tablets are round in shape, white in color and have a special “DLI” engraving above the line on both sides. The tablets are packaged in aluminum strips of 10 or 15 pieces. A cardboard pack contains 5 (10 pieces each) or 3 (15 pieces each) strips.

Lasix in 2 ml ampoules is a clear solution. There are 10 ampoules in a cardboard pack.

The tablet contains 40 mg and additional components: colloidal form of silicon dioxide, talc, lactose, Mg stearate, pregelatinized starch.

1 ml of solution contains 10 mg of furosemide (20 mg in an ampoule) and additional components: Na hydroxide, Na chloride and water.

Pharmacological action

Lasix has a pronounced diuretic (diuretic) and moderate hypotensive (lowering blood pressure) effect. The diuretic effect of the drug is achieved by blocking the reabsorption of sodium and chlorine. Furosemide penetrates into the renal tubule, in particular to its loop-shaped part (Hegel's loop) and there blocks the reabsorption of Na+ and Cl ions.

An increase in the release of sodium ions entails an increased release of fluid, potassium, calcium and magnesium. When the injection solution is administered intravenously, the diuretic effect is observed within 5 minutes and lasts for two hours. When taking Lasix tablets, diuresis occurs within an hour and lasts about seven hours.

The hypotensive effect of the drug occurs as a result of increasing the secretion of sodium chloride (salt) and preventing vasoconstriction due to a decrease in circulating blood volume. The hypotensive effect is more effective when administered intravenously. Quite quickly reduces blood pressure, as well as pressure in the left ventricle and pulmonary artery, dilates large veins and thus reduces the preload of the heart.

With intravenous administration, the pressure decreases within 5-10 minutes; if the medicine is used in tablets, the pressure returns to normal within an hour and remains within normal limits for 2-3 hours.

Indications for use

What does Lasix help with? Tablets and injections are used mainly for edema syndrome. Main indications for the use of Lasix:

• cerebral edema;
• hypertensive crisis;
• edema syndrome in chronic heart failure;
• edema syndrome in heart failure (acute form);
• edema syndrome in chronic pathology of the renal system;
• acute renal failure during burns (maintaining fluid excretion), during pregnancy;
• edema syndrome due to pathology of the hepatic system (in combination with aldosterone antagonists);
• edema syndrome in nephrotic syndrome (together with therapy of the underlying disease);
• support for forced diuresis during intoxication with a chemical compound that is excreted unchanged through the renal system.

Instructions for use

When prescribing Lasix, it is recommended to use the smallest doses sufficient to achieve the required therapeutic effect. Tablets should be taken on an empty stomach without chewing and drinking enough liquid.

The ampoule form of the drug is administered intravenously and, in exceptional cases, intramuscularly (when intravenous or oral administration of the drug is not possible). Intravenous administration of the drug Lasix is ​​carried out only when taking the drug orally is not possible or there is a malabsorption of the drug in the small intestine or if it is necessary to obtain the fastest possible effect.

When using intravenous Lasix, it is always recommended that the patient be switched to oral Lasix as early as possible.

When administered intravenously, Lasix should be administered slowly. The rate of intravenous administration should not exceed 4 mg per minute. In patients with severe renal impairment (serum creatinine >5 mg/dL), it is recommended that the rate of intravenous administration of Lasix do not exceed 2.5 mg per minute.

To achieve optimal effectiveness and suppression of counter-regulation (activation of renin-angiotensin and antinatriuretic neurohumoral regulation), prolonged intravenous infusion of Lasix should be preferable to repeated intravenous administration of the drug.

If a continuous intravenous infusion is not possible after one or more intravenous bolus doses in an acute setting, administering low doses with short intervals between doses (approximately 4 hours) is preferable to higher dose intravenous bolus administration with long intervals between doses. introductions.

The solution for parenteral administration has a pH of about 9 and does not have buffering properties. At a pH below 7, the active substance may precipitate, therefore, when diluting Lasix, it is necessary to ensure that the pH of the resulting solution ranges from neutral to slightly alkaline. For dilution, you can use saline solution.

The diluted solution of Lasix should be used as soon as possible. The recommended maximum daily intravenous dose for adults is 1500 mg. In children, the recommended dose for parenteral administration is 1 mg/kg body weight (but not more than 20 mg per day). The duration of treatment is determined by the doctor individually depending on the indications.

Arterial hypertension

Lasix can be used alone or in combination with other antihypertensive agents. The usual maintenance dose is 20-40 mg per day. In case of arterial hypertension in combination with chronic renal failure, higher doses of Lasix may be required.

Hypertensive crisis, cerebral edema

Maintaining forced diuresis during poisoning

Furosemide is prescribed after intravenous infusion of electrolyte solutions. The recommended starting dose for intravenous administration is 20-40 mg. The dose depends on the response to furosemide. Before and during treatment with Lasix, fluid and electrolyte losses should be monitored and replaced.

Edema in nephrotic syndrome

Acute renal failure (to maintain fluid excretion)

Before starting treatment with Lasix, hypovolemia, arterial hypotension and significant disturbances in electrolyte and acid-base status must be eliminated. It is recommended that the patient be switched from intravenous administration of the drug to taking Lasix tablets as soon as possible (the dose of tablets depends on the selected intravenous dose).

The recommended initial intravenous dose is 40 mg. If after its administration the required diuretic effect is not achieved, then Lasix can be administered as a continuous intravenous infusion, starting at an administration rate of 50-100 mg per hour.

Edema syndrome in chronic heart failure

Edema syndrome in chronic renal failure

The natriuretic response to furosemide depends on several factors, including the severity of renal impairment and blood sodium levels, so the dose response cannot be accurately predicted.

In patients with chronic renal failure, careful selection of the dose is required, by gradually increasing it so that fluid loss occurs gradually (at the beginning of treatment, fluid loss of up to approximately 2 kg of body weight per day is possible).

In patients on hemodialysis, the usual maintenance dose is 250-1500 mg per day.

When administered intravenously, the dose of furosemide can be determined as follows: treatment begins with an intravenous drip at a rate of 0.1 mg per minute, and then gradually increases the rate of administration every 30 minutes depending on the therapeutic effect.

Edema syndrome in acute heart failure

Edema syndrome in liver diseases

Furosemide is prescribed in addition to treatment with aldosterone antagonists if they are insufficiently effective.

To prevent the development of complications, such as impaired orthostatic regulation of blood circulation or disturbances in electrolyte or acid-base status, careful dose selection is required so that fluid loss occurs gradually (at the beginning of treatment, fluid loss of up to approximately 0.5 kg of body weight per day is possible).

If intravenous administration is absolutely necessary, the initial dose for intravenous administration is 20-40 mg.

Contraindications

• Severe disturbance of urine outflow of any origin;
• Hypersensitivity to the components of Lasix;
• Severe disturbance of acid-base and water-salt balance: hypokalemia, hyponatremia, hypovolemia (without arterial hypotension or with it), dehydration;
• Pregnancy and breastfeeding period;
• Hepatic precoma and coma;
• Renal failure with anuria (in the absence of response to furosemide).

The drug is contraindicated in patients with allergies to sulfonylureas or sulfonamide antimicrobials (possible cross-allergy to furosemide).

In addition, the use of Lasix tablets is contraindicated:

• An increase in central venous pressure by more than 10 mmHg;
• Age up to 3 years;
• Acute glomerulonephritis;
• Decompensated mitral and aortic stenosis, hypertrophic obstructive cardiomyopathy;
• Digitalis intoxication;
• Hyperuricemia.

Lasix solution should be used with caution in patients with hearing loss and premature infants (due to possible nephrolithiasis and nephrocalcinosis, renal function should be regularly monitored, including ultrasound).

Side effects

When using the drug Lasix with an inadequate dosage regimen, the patient quickly develops negative side reactions:

• The risk of developing thrombosis due to changes in water and electrolyte balance;
• From the cardiovascular system - a rapid decrease in blood pressure, dizziness, weakness, lethargy, drowsiness, vascular insufficiency, collapse;
• Acute urinary retention, development of hydronephrosis, hematuria, glomerulonephritis;
• People prone to allergic reactions may develop rashes, hives and itching of the skin;
• Reversible hearing impairment;
• Feeling of “pins and needles” crawling through the body;
• From the side of water-salt balance - a decrease in the blood level of potassium, sodium, chlorine, magnesium, calcium, against the background of which metabolic alkalosis and disorder of the function of the kidneys and other vital organs rapidly develop;
• An increase in blood serum levels of cholesterol, triglycerides, fats;
• Decreased glucose tolerance;
• From the digestive canal – nausea, vomiting, diarrhea, intrahepatic cholestasis, increased activity of hepatic transminases.

Children, pregnancy and breastfeeding

The active component penetrates the placental barrier, so the drug should not be prescribed during pregnancy. If, for health reasons, Lasix is ​​prescribed to pregnant women, then careful monitoring of the condition of the fetus is necessary. Lasix is ​​contraindicated during breastfeeding. Furosemide suppresses lactation.

Use in children

Contraindicated in children under 3 years of age (solid dosage form).

Special instructions

Use with caution for prostatic hyperplasia, hypoproteinemia, and stenotic atherosclerosis of the cerebral arteries. Do not mix furosemide solution in the same syringe with other drugs.

Drug interactions

Blood pressure-lowering medications, diuretics, and antihypertensive drugs in combination with Lasix can cause a sharp drop in blood pressure.

ACE inhibitors can lead to a deterioration in the functional state of the renal system and provoke hypotension. In severe cases, acute renal failure develops.

Carbenoxolone, glucocorticosteroids, drugs with licorice root, laxatives in combination with Lasix increase the risk of developing hypokalemia.

It has been noted that furosemide is able to enhance the nephrotoxic and ototoxic effects of aminoglycosides due to delayed excretion through the renal system. The nephrotoxic effects of medications are enhanced by parallel treatment with furosemide. Kidney damage is also recorded with the use of high doses of cephalosporins, the predominant route of elimination of which is through the renal system.

The severity of the diuretic effect of Lasix is ​​reduced when taking NSAIDs. With severe dehydration and hypovolemia, NSAIDs can provoke the development of acute renal failure. Lasix enhances the toxic effects of salicylates. During treatment with Phenytoin, the severity of the diuretic effect of furosemide decreases.

Cisplatin with furosemide has a pronounced ototoxic effect. The administration of high doses (more than 40 mg) increases the nephrotoxic effect of Cisplatin.

Analogues of the drug Lasix

Analogues are determined by structure:

1. Fursemid.
2. Furosemide.
3. Furon.

The group of diuretics includes analogues:

1. Nebilong N.
2. Isobar.
3. Lespeflan.
4. Oxodolin.
5. Urea.
6. Kristepin.
7. Arindap.
8. Hygroton.
9. Arifon.
10. Hypothiazide.
11. Urological (diuretic) collection.
12. Indapres.
13. Urakton.
14. Akuter Sanovel.
15. Ionic.
16. Normatens.
17. Clopamid.
18. Spironol.
19. Spironolactone.
20. Diuver.
21. Lespenefril.
22. Aldactone.
23. Canephron H.
24. Lespefril.
25. Acripamide retard.
26. Hydrochlorothiazide.
27. Lorvas.
28. Indap.
29. Aquaphor.
30. Triamtel.
31. Brinaldix.
32. Bufenox.
33. Verospilactone.
34. Mannitol.
35. Acripamide.
36. Torsemide.
37. Phytolysin.
38. Brusniver.
39. Diacarb.
40. Mannitol.
41. Cimalon.

Vacation conditions and price

The average cost of Lasix (40 mg tablets No. 45) in Moscow is 55 rubles. The price of injections is 90 rubles for 10 ampoules of 2 ml. Dispensed by prescription.

Store out of reach of children at a temperature not exceeding +25° C. Shelf life of tablets is 4 years, solution for injection is 5 years.

| Lasix

Analogs (generics, synonyms)

Recipe

Rp: Sol. Lasix 2.0
D.t. d. N 5 in amp.
S. For intramuscular administration 2.0

Rp: Tab. Lasix 40 mg
D.t.d. N50 in tabyl.
S. According to the scheme.

Pharmacological action

"Loop" diuretic; causes rapid, strong and short-term diuresis. It has natriuretic and chloruretic effects, increases the excretion of K+, Ca2+, Mg2+. Penetrating into the lumen of the renal tubule in the thick segment of the ascending limb of the loop of Henle, it blocks the reabsorption of Na+ and Cl-. Due to increased Na+ excretion, there is a secondary (osmotically bound water-mediated) increased excretion of water and an increase in K+ secretion in the distal part of the renal tubule. At the same time, the excretion of Ca2+ and Mg2+ increases.
The drug has secondary effects due to the release of intrarenal mediators and redistribution of intrarenal blood flow. During the course of treatment, the effect does not weaken.
In heart failure, it quickly leads to a decrease in preload on the heart through dilatation of large veins. It has a hypotensive effect due to an increase in the excretion of NaCl and a decrease in the response of vascular smooth muscles to vasoconstrictor effects and as a result of a decrease in blood volume.
The effect of Lasix after intravenous administration occurs within 5-10 minutes; after taking the drug orally - after 30-60 minutes, maximum effect - after 1-2 hours, duration of effect - 2-3 hours (with reduced kidney function - up to 8 hours).

During the period of action of Lasix, Na+ excretion increases significantly, but after its cessation, the excretion rate decreases below the initial level (rebound or withdrawal syndrome). The phenomenon is caused by a sharp activation of renin-angiotensin and other antinatriuretic neurohumoral regulation units in response to massive diuresis; stimulates the arginine-vasopressive and sympathetic systems.
Lasix therapy reduces the level of atrial natriuretic factor in plasma and causes vasoconstriction. Due to the “rebound” phenomenon, taking the drug once a day may not have a significant effect on the daily excretion of Na+ and blood pressure.

Directions for use

IV (rarely IM), parenteral administration of Lasix is ​​advisable in cases where it is not possible to take it orally - in urgent situations or in cases of pronounced edema syndrome.

Edema syndrome: the initial dose of Lasix is ​​40 mg. IV administration is carried out within 1-2 minutes; in the absence of a diuretic response, a dose increased by 50% is administered every 2 hours until adequate diuresis is achieved.

The average daily dose for intravenous administration in children is 0.5-1.5 mg/kg, the maximum is 6 mg/kg. Patients with reduced glomerular filtration and low diuretic response are prescribed in large doses - 1-1.5 g. The maximum single dose is 2 g.

Orally, in the morning, before meals, the average single initial dose is 20-80 mg; in the absence of a diuretic response, the dose is increased by 20-40 mg every 6-8 hours until an adequate diuretic response is obtained.
A single dose, if necessary, can be increased to 600 mg or more (required when glomerular filtration rate and hypoproteinemia decrease).

For arterial hypertension, 20-40 mg is prescribed; in the absence of a sufficient reduction in blood pressure, other antihypertensive drugs must be added to Lasix treatment.
When adding Lasix to already prescribed antihypertensive drugs, their dose should be reduced by 2 times.
The initial single dose of the drug in children is 2 mg/kg, the maximum is 6 mg/kg

Indications

Edema syndrome developed as a result of:
- heart diseases;
- kidney diseases;
- liver diseases;
- acute left ventricular failure;
- burn disease;
- preeclampsia in pregnant women (the use of Lasix is ​​possible only after restoration of the blood volume).

Forced diuresis.

Complex therapy of arterial hypertension.

Contraindications

Hypersensitivity to the components of Lasix,
acute renal failure with anuria (glomerular filtration rate less than 3-5 ml/min),
severe liver failure,
hepatic coma and precoma,
urethral stenosis,
acute glomerulonephritis,
obstruction of the urinary tract by stones, precomatose states,
hyperglycemic coma,
hyperuricemia,
gout,
decompensated mitral or aortic stenosis,
GOKMP,
increased central venous pressure (over 10 mm Hg),
arterial hypotension,
acute myocardial infarction,
pancreatitis,
disturbance of water and electrolyte metabolism (hypovolemia, hyponatremia, hypokalemia, hypochloremia, hypocalcemia, hypomagnesemia),
digitalis intoxication.

With caution:
prostatic hyperplasia, SLE, hypoproteinemia (risk of developing ototoxicity), diabetes mellitus (decreased glucose tolerance), stenotic atherosclerosis of the cerebral arteries, pregnancy (especially the first half, possible use for health reasons), lactation period.

Side effects

Hypotension,
arrhythmia,
dry mouth,
nausea,
vomit,
diarrhea,
pancreatitis,
hypovolemia,
dehydration,
hypokalemia,
hyponatremia,
hypochloremia,
metabolic alkalosis,
hypocalcemia,
hyperuricemia,
dermatitis,
hearing impairment,
vision,
paresthesia,
dizziness,
muscle weakness,
urinary retention in patients with prostate adenoma, hypercholesterolemia,
hypertriglyceridemia,
decreased glucose tolerance,
acute pancreatitis,
allergic reactions (rashes, fever, vasculitis, interstitial nephritis);

in premature babies - nephrocalcinosis.

Release form

Tablets: round, almost white or white in color, engraved “DLI” on one side below and above the dividing line (in aluminum foil strips:
10 pcs., 5 strips in a cardboard box;
15 pcs., 3 strips in a cardboard pack);

Solution for intravenous (IV) and intramuscular (IM) administration: transparent colorless liquid (2 ml in dark glass ampoules with a breaking point, 10 pcs. in a blister plastic package, 1 package in a cardboard box).

ATTENTION!

The information on the page you are viewing is created for informational purposes only and does not in any way promote self-medication. The resource is intended to provide healthcare workers with additional information about certain medications, thereby increasing their level of professionalism. The use of the drug "" necessarily requires consultation with a specialist, as well as his recommendations on the method of use and dosage of the medicine you have chosen.

Lasix successfully copes with renal and cardiac edema and is used in the complex treatment of cerebral and pulmonary edema. It is important to observe the dosage and frequency of administration, and also be aware of contraindications

Diuretics are used for many common diseases and pathological processes in the human body. The pharmacy chain offers a large number of drugs, differing in the degree of influence, characteristics and other parameters. One of the strong diuretics is Lasix. The diuretic is highly effective and has a minimum of side effects.

Features of the drug

Lasix is ​​the trade name of the drug. The main active ingredient is furosemide, a sulfonamide derivative. This is a representative of the so-called, it has a special chemical structure and has the property of increasing the amount of fluid removed from the body. Lasix has an effect on the area of ​​the kidney called the loop of Henle, hence the name of the entire group of diuretics – loop diuretics. In addition to being a diuretic, the drug exhibits a moderate hypotensive effect compared to the group of thiazide drugs.

The diuretic effect develops after the reabsorption of sodium and chlorine ions ceases.

The blockage occurs in the loop-shaped part of the kidney tubules. This leads to an increase in osmotic pressure in the tubules. Fluid filtered by the kidneys cannot be reabsorbed. Sodium ions, without entering the bloodstream, carry away excess fluid, reducing swelling.

The drug lowers blood pressure. Increased sodium excretion and a decrease in the amount of circulating fluid reduce the tension of the vascular walls and promote the dilation of veins. The filling of the blood vessels of the left ventricle and pulmonary artery decreases.

Characteristics of Lasix

The drug has several dosage forms, which allows it to be used both for emergency care and for routine treatment. Tablets are used for oral administration. They are round, whitish, with a dividing groove and the letters - DLI. The preparations are packaged in aluminum foil, 15 or 10 pieces per plate. One box has 3 plates, respectively, 45 tablets or 5 plates - 50 pieces. And one tablet contains 40 mg of furosemide. In addition to it, excipients are used: corn and pregelatinized starch, silicon dioxide in colloidal form, magnesium stearate, sweetener and talc.

The injection is a liquid in a transparent glass ampoule.

The diuretic Lasix for injection contains 10 mg of furosemide in 1 ml of solution. Auxiliary elements are sodium chloride and hydroxide, water for injection. The drug is produced in ampoules of 2 ml. The containers are included in a box of 10 pieces.

When tested in healthy people, the bioavailability of the active substance reached 70%; for patients this figure decreases to 30%. The tablets are easily absorbed through the gastrointestinal mucosa. Tablet forms begin to act after an hour, reaching maximum concentration after 1.5 hours. The effect is observed for 7 hours. The injection of the drug gives results in 5 minutes, and the effect lasts up to two hours.

During storage, avoid exposure to light on the drug; temperature conditions should be up to 25 ° C. The box with the medicine should be inaccessible to children. You should check how long the medicine has been sold; you should not use an expired medicine.

Indications for use

The pharmaceutical product can only be used as directed by a specialist doctor, strictly observing the dosage. Lasix as a diuretic is used to relieve edema syndrome of different localization in the following situations:

• edema associated with cardiac insufficiency;
• acute renal pathology;
• to stimulate urination during;
• swelling resulting from burns;
• as a means of complex therapy during a hypertensive crisis;
• increased diuresis for patients with liver damage;
• swelling with diffuse changes in the kidney tubules;
• formation of free fluid in the lungs;
• pathological changes (swelling) and edema of the brain.

Lasix is ​​used to treat eclampsia in women during pregnancy. The severity of this condition is due to high blood pressure and severe swelling. With eclampsia, rapid weight gain occurs and proteinuria develops. Furosemide easily crosses the placental barrier, so before use, the doctor must evaluate the benefits of the drug for the mother and the harmful effects for the fetus.

It is better to take Lasix in the morning. In parallel with the medicine, be sure to drink potassium and magnesium supplements to avoid leaching of these important microelements. These are products such as Panangin or Asparkam. Sometimes it becomes necessary to use Lasix to lower potassium in the blood when its levels exceed the norm. The product in solution is used for decompensated cardiac pathology, severe pulmonary and cerebral edema, general intoxication of the body, especially for large-area burns.

Contraindications

Despite the effectiveness of the drug, there are many contraindications to its use:

• imbalance of blood electrolyte composition;
• allergic reaction to the active substance or one of its components;
• anuria – a decrease in a person’s diuresis of less than 50 ml of urine per day;
• Lasix is ​​not prescribed for a sharp decrease in circulating blood volume;
• in case of hepatic coma at any stage.

The drug is contraindicated during pregnancy for up to three months, as it can harm the fetus during the formation of vital organs. In later stages, treatment with Lasix is ​​possible for urgent reasons and only with the permission of the doctor. The drug passes into breast milk, for this reason the medicine is not prescribed to a nursing woman, or to children under three years of age.

Pathology of the urinary system - narrowing of the urethra, kidney dysfunction, when urine does not enter the bladder - this is also an absolute contraindication. You should not take Lasix if you have inflammation of the pancreas, gout, or low blood pressure.

A diuretic is not used if the patient has a lack of microelements such as potassium and magnesium in the body.

Before starting treatment, the patient undergoes tests to find out the amount of microelements in the blood. The drug reduces the psychomotor reaction; while taking it, you must refrain from work that requires concentration and attention. The acute form of glomerulonephritis is also a contraindication for the use of Lasix. If a person is in a state of renal coma, such a diuretic is not prescribed.

Side effects of the drug

The main drawback when using the drug is the change in electrolyte balance. A biochemical blood test reveals elevated levels of creatinine, glucose, cholesterol, and uric acid. In addition, Lasix tablets can cause the following conditions:

• decrease in the amount of circulating fluid in the bloodstream;
• shift in leukocyte formula;
• thrombosis and blood thickening;
• skin erythema, itching, dermatitis;
• Rarely, anaphylactic shock may develop;
• Treatment with Lasix in newborns leads to pathology of the ductus arteriosus.

In addition, a person during such therapy may experience headaches, dizziness, hearing loss, weakness, and drowsiness. The heart rate increases, nausea, vomiting, diarrhea are possible, a feeling of dry mouth, and bloating appear. Skin redness and itching are often observed. Heart rhythm is disturbed.

The frequency of side effects depends on the patient’s age and diet. Lasix can reduce metabolism and male potency, provoke diabetes, and disrupt kidney function. It is necessary to take into account the interaction of Lasix with other drugs. Particular care should be taken when combining a diuretic with a laxative, antibiotics, hormonal and non-steroidal anti-inflammatory drugs. Caution should be taken when taking tablets together with antihypertensive drugs.

Lasix is ​​a fast-acting diuretic, whose chemical structure is a sulfonamide derivative. So that the reader immediately understands what we are talking about - this is the original drug furosemide from the global pharmaceutical corporation Sanofi Aventis. The mechanism of the diuretic action of Lasix is ​​to inhibit the reabsorption (reabsorption) of sodium and chlorine ions in the renal tubules. Thus, the body is more willing to part with sodium (with chlorine too, but the former has much greater clinical significance), as a result of which a whole cascade of secondary effects is potentiated: an increase in the volume of urine excreted, increased excretion of potassium, calcium and magnesium ions. It is characteristic that when taking Lasix again, its diuretic activity does not weaken. In patients with chronic heart failure, the drug quickly reduces preload (this occurs due to dilation of the vessels of the venous bed), “bleeds off steam” (read: reduces pressure) in the pulmonary artery system and the left ventricular chamber. Experts believe that Lasix owes its rapid pharmacological effect to prostaglandins, so a necessary condition for the drug to work “to its fullest” is the normal functioning of the prostaglandin system, as well as adequate kidney function. Lasix has an antihypertensive effect based on increased sodium excretion from the body, increased diuresis and an associated decrease in circulating blood volume, and a decrease in the sensitivity of the smooth muscle walls of blood vessels to the vasoconstrictor effect. In the latter case, we are talking, first of all, about catecholamines: due to increased sodium excretion, Lasix softens the increased (which is typical for hypertensive patients) vascular response to these powerful vasoconstrictors. As clinical studies involving healthy volunteers have shown, the diuretic and saluretic effects of Lasix are observed when taking the drug in the range of 10 to 100 mg.

After parenteral administration of 20 mg of the drug, the diuretic effect began to appear after 15 minutes and lasted about 3 hours.

The manufacturer has mastered the production of two dosage forms of Lasix: tablets and solution for intravenous and intramuscular administration. Treatment with Lasix is ​​recommended using the lowest effective doses of the drug. It should be noted that the therapeutic effect of the drug is dose-dependent, and also mention that Lasix has a very high pharmacological “ceiling” (its activity increases over a wide range of doses). Despite the stated two routes of parenteral administration (intravenous and intramuscular), the second of them is used only in exceptional cases when it is not possible to inject the solution into a vein or take a tablet. The intravenous and oral routes of administration are similarly correlated: injection is performed only in situations where for some reason it is impossible to take the drug orally, there are disturbances in the absorption of furosemide in the small intestine, or an extremely rapid therapeutic effect is required. When using the injectable form of Lasix, it is recommended to switch the patient to the tablet form as quickly as possible. Before starting pharmacotherapy, it is necessary to exclude the presence of pronounced disorders of urodynamics (urine outflow). During treatment, it is desirable to monitor the concentrations of sodium, potassium, and creatinine ions in the blood. Particularly careful monitoring should be carried out for patients prone to disturbances in water and electrolyte balance (which may be caused by diarrhea, vomiting or intense hyperhidrosis). During the medication course, it is recommended to enrich your diet with potassium, for which foods such as lean meat, tomatoes, cauliflower, spinach, potatoes, bananas, dried fruits, etc. are included in the menu. Sometimes, depending on the situation, you may need to take potassium supplements.

Pharmacology

Lasix is ​​a strong and fast-acting diuretic that is a sulfonamide derivative. Lasix blocks the transport system of Na + , K + , Cl - ions in the thick segment of the ascending limb of the loop of Henle, and therefore its diuretic effect depends on the entry of the drug into the lumen of the renal tubules (due to the anion transport mechanism). The diuretic effect of Lasix is ​​associated with inhibition of sodium chloride reabsorption in this section of the loop of Henle. Secondary effects to the increase in sodium excretion are: an increase in the amount of urine excreted (due to osmotically bound water) and an increase in potassium secretion in the distal part of the renal tubule. At the same time, the excretion of calcium and magnesium ions increases. When tubular secretion of furosemide decreases or when the drug binds to albumin located in the tubular lumen (for example, in nephrotic syndrome), the effect of furosemide is reduced.

When taking Lasix for a course, its diuretic activity does not decrease, since the drug interrupts the tubular-glomerular feedback in the Macula densa (a tubular structure closely associated with the juxtaglomerular complex). Lasix causes dose-dependent stimulation of the renin-angiotensin-aldosterone system.

In heart failure, Lasix quickly reduces preload (by dilating the veins), reduces pulmonary artery pressure and left ventricular filling pressure. This rapidly developing effect appears to be mediated through the effects of prostaglandins and therefore the condition for its development is the absence of disturbances in the synthesis of prostaglandins, in addition to which the realization of this effect also requires sufficient preservation of renal function.

The drug has a hypotensive effect, which is caused by an increase in sodium excretion, a decrease in circulating blood volume and a decrease in the response of vascular smooth muscle to vasoconstrictor stimuli (due to the natriuretic effect, furosemide reduces the vascular response to catecholamines, the concentration of which is increased in patients with arterial hypertension).

After oral administration of 40 mg of Lasix, the diuretic effect begins within 60 minutes and lasts about 3-6 hours.

In healthy volunteers receiving 10 to 100 mg of Lasix, dose-dependent diuresis and natriuresis were observed.

Pharmacokinetics

Furosemide is rapidly absorbed into the gastrointestinal tract. Its Tmax (time to reach Cmax in the blood) ranges from 1 to 1.5 hours. The bioavailability of furosemide in healthy volunteers is approximately 50-70%. In patients, the bioavailability of Lasix can be reduced by up to 30%, as it can be influenced by various factors, including the underlying disease. V d of furosemide is 0.1-0.2 l/kg body weight. Furosemide binds very strongly to plasma proteins (more than 98%), mainly to albumin.

Furosemide is excreted predominantly unchanged and mainly by secretion in the proximal tubules. Glucuronidated metabolites of furosemide account for 10-20% of the drug excreted by the kidneys. The remaining dose is excreted through the intestines, apparently by biliary secretion. The final half-life of furosemide is approximately 1-1.5 hours.

Furosemide penetrates the placental barrier and is excreted into breast milk. Its concentrations in the fetus and newborn are the same as in the mother.

Features of pharmacokinetics in certain groups of patients

In renal failure, the elimination of furosemide slows down and the half-life increases; with severe renal failure, the final T1/2 may increase to 24 hours.

In nephrotic syndrome, a decrease in plasma protein concentrations leads to an increase in the concentrations of unbound furosemide (its free fraction), and therefore the risk of developing ototoxicity increases. On the other hand, the diuretic effect of furosemide in these patients may be reduced due to the binding of furosemide to tubular albumin and decreased tubular secretion of furosemide.

During hemodialysis and peritoneal dialysis and continuous outpatient peritoneal dialysis, furosemide is excreted insignificantly.

In case of liver failure, T1/2 of furosemide increases by 30-90%, mainly due to an increase in Vd. Pharmacokinetic parameters in this category of patients can vary greatly.

In heart failure, severe arterial hypertension and in the elderly, the excretion of furosemide slows down due to decreased renal function.

Release form

Tablets are white or almost white, round, with “DLI” engraved above and below the lines on one side.

	1 tab.
furosemide	40 mg

Excipients: lactose, starch, pregelatinized starch, talc, colloidal silicon dioxide, magnesium stearate.

10 pcs. - aluminum foil strips (5) - cardboard packs.
15 pcs. - aluminum foil strips (3) - cardboard packs.

Dosage

The tablets should be taken on an empty stomach, without chewing and with sufficient liquid. When prescribing Lasix, it is recommended to use the smallest doses sufficient to achieve the desired effect. The recommended maximum daily dose for adults is 1500 mg. In children, the recommended oral dose is 2 mg/kg body weight (but not more than 40 mg/day). The duration of treatment is determined by the doctor individually depending on the indications.

Edema syndrome in chronic heart failure

Edema syndrome in chronic renal failure

The natriuretic response to furosemide depends on several factors, including the severity of renal impairment and blood sodium levels, so the dose response cannot be accurately predicted. In patients with chronic renal failure, careful selection of the dose is required, by gradually increasing it so that fluid loss occurs gradually (at the beginning of treatment, fluid loss of up to approximately 2 kg of body weight / day is possible).

The recommended starting dose is 40-80 mg/day. The required dose is selected depending on the diuretic response. The entire daily dose should be taken once or divided into two doses. In patients on hemodialysis, the maintenance dose is usually 250-1500 mg/day.

Acute renal failure (to maintain fluid excretion)

Before starting treatment with furosemide, hypovolemia, arterial hypotension and significant disturbances in electrolyte and acid-base status must be eliminated. It is recommended to switch the patient from IV Lasix to Lasix tablets as quickly as possible (the dose of Lasix tablets depends on the IV dose selected).

Edema syndrome in liver diseases

Lasix is ​​prescribed in addition to treatment with aldosterone antagonists if they are insufficiently effective. To prevent the development of complications, such as impaired orthostatic regulation of blood circulation or disturbances in electrolyte or acid-base status, careful dose selection is required so that fluid loss occurs gradually (at the beginning of treatment, fluid loss of up to approximately 0.5 kg of body weight/day is possible). The recommended starting dose is 20-80 mg/day.

Arterial hypertension

Lasix can be used alone or in combination with other antihypertensive agents. The usual maintenance dose is 20-40 mg/day. In case of arterial hypertension in combination with chronic renal failure, higher doses of Lasix may be required.

Overdose

If you suspect an overdose, you should definitely consult a doctor, since in case of an overdose, certain therapeutic measures may be required.

The clinical picture of acute or chronic drug overdose depends mainly on the degree and consequences of loss of fluid and electrolytes; overdose may be manifested by hypovolemia, dehydration, hemoconcentration, cardiac rhythm and conduction disturbances (including atrioventricular block and ventricular fibrillation). Symptoms of these disorders are arterial hypotension (up to the development of shock), acute renal failure, thrombosis, delirium, flaccid paralysis, apathy and confusion.

There is no specific antidote. If a little time has passed after oral administration, then to reduce the absorption of furosemide from the gastrointestinal tract, you should try to induce vomiting or perform gastric lavage, and then take activated charcoal orally. Treatment is aimed at correcting clinically significant disturbances in water-electrolyte and acid-base status under the control of serum concentrations of electrolytes, acid-base status indicators, hematocrit, as well as at preventing or treating possible serious complications developing against the background of these disorders.

Interaction

Cardiac glycosides, drugs that cause prolongation of the QT interval - if electrolyte disturbances (hypokalemia or hypomagnesemia) develop while taking furosemide, the toxic effect of cardiac glycosides and drugs that cause prolongation of the QT interval increases (the risk of developing rhythm disturbances increases).

Glucocorticosteroids, carbenoxolone, licorice in large quantities and prolonged use of laxatives when combined with furosemide increase the risk of developing hypokalemia.

Aminoglycosides - slowing down the excretion of aminoglycosides by the kidneys when used simultaneously with furosemide and increasing the risk of developing ototoxic and nephrotoxic effects of aminoglycosides. For this reason, the use of this combination of drugs should be avoided unless it is necessary for health reasons, in which case an adjustment (reduction) of maintenance doses of aminoglycosides is required.

Medicines with nephrotoxic effects - when combined with furosemide, the risk of developing nephrotoxic effects increases.

High doses of some cephalosporins (especially those with a predominantly renal route of elimination) - in combination with furosemide, increase the risk of nephrotoxicity.

Cisplatin - when used simultaneously with furosemide, there is a risk of ototoxicity. In addition, in the case of co-administration of cisplatin and furosemide in doses above 40 mg (with normal renal function), the risk of developing the nephrotoxic effect of cisplatin increases.

Nonsteroidal anti-inflammatory drugs (NSAIDs) - NSAIDs, including acetylsalicylic acid, may reduce the diuretic effect of furosemide. In patients with hypovolemia and dehydration (including while taking furosemide), NSAIDs can cause the development of acute renal failure. Furosemide may enhance the toxic effects of salicylates.

Phenytoin - reduces the diuretic effect of furosemide.

Antihypertensive drugs, diuretics or other drugs that can lower blood pressure - when combined with furosemide, a more pronounced hypotensive effect is expected.

Angiotensin-converting enzyme (ACE) inhibitors - prescribing an ACE inhibitor to patients previously treated with furosemide can lead to an excessive decrease in blood pressure with deterioration of renal function, and in some cases to the development of acute renal failure, therefore three days before starting treatment with inhibitors ACEs or increasing their dose, it is recommended to discontinue furosemide or reduce its dose.

Probenicide, methotrexate or other drugs that, like furosemide, are secreted in the renal tubules, can reduce the effects of furosemide (the same route of renal secretion), on the other hand, furosemide can lead to a decrease in the renal excretion of these drugs.

Hypoglycemic agents, pressor amines (epinephrine, norepinephrine) - weakening effects when combined with furosemide.

Theophylline, diazoxide, curare-like muscle relaxants - enhanced effects when combined with furosemide.

Lithium salts - under the influence of furosemide, the excretion of lithium decreases, thereby increasing the serum concentration of lithium and increasing the risk of developing the toxic effects of lithium, including its damaging effects on the heart and nervous system. Therefore, monitoring of serum lithium concentrations is required when using this combination.

Sucralfate - reduces the absorption of furosemide and weakens its effect (furosemide and sucralfate should be taken at least two hours apart).

Cyclosporine A - when combined with furosemide, the risk of developing gouty arthritis increases due to hyperuricemia caused by furosemide and impairment of urate excretion by the kidneys by cyclosporine.

Radiocontrast agents - Patients at high risk of developing contrast agent nephropathy who received furosemide had a higher incidence of renal dysfunction compared with patients at high risk of developing contrast agent nephropathy who received only intravenous hydration before administration of radiocontrast agent.

Side effects

From the water-electrolyte and acid-base state

Hyponatremia, hypochloremia, hypokalemia, hypomagnesemia, hypocalcemia, metabolic alkalosis, which can develop in the form of either a gradual increase in electrolyte deficiency or massive loss of electrolytes over a very short time, for example, in the case of high doses of furosemide in patients with normal renal function. Symptoms indicating the development of electrolyte and acid-base imbalances may include headache, confusion, convulsions, tetany, muscle weakness, cardiac arrhythmias, and dyspeptic disorders. Factors contributing to the development of electrolyte disturbances include underlying diseases (for example, cirrhosis of the liver or heart failure), concomitant medications and poor nutrition. In particular, vomiting and diarrhea may increase the risk of hypokalemia. Hypovolemia (decrease in circulating blood volume) and dehydration (more often in elderly patients), which can lead to hemoconcentration with a tendency to develop thrombosis.

From the cardiovascular system

An excessive decrease in blood pressure, which, especially in elderly patients, can be manifested by the following symptoms: impaired concentration and psychomotor reactions, headache, dizziness, drowsiness, weakness, visual disturbances, dry mouth, impaired orthostatic regulation of blood circulation; collapse.

Metabolism

Increased serum levels of cholesterol and triglycerides, transient increases in creatinine and urea levels in the blood, increased serum uric acid concentrations, which can cause or worsen the manifestations of gout. Decreased glucose tolerance (possible manifestation of latent diabetes mellitus).

From the urinary system

The appearance or intensification of symptoms caused by an existing obstruction to the outflow of urine, up to acute urinary retention with subsequent complications (for example, prostatic hypertrophy, narrowing of the urethra, hydronephrosis); hematuria, decreased potency.

From the gastrointestinal tract

Rarely - nausea, vomiting, diarrhea, constipation; isolated cases of intrahepatic cholestasis, increased levels of liver transaminases, acute pancreatitis.

From the central nervous system, hearing organ

In rare cases - hearing impairment, usually reversible, and/or tinnitus, especially in patients with renal failure or hypoproteinemia (nephrotic syndrome), rarely - paresthesia.

From the skin, allergic reactions

Rarely - allergic reactions: skin itching, urticaria, other types of rash or bullous skin lesions, erythema multiforme, exfoliative dermatitis, purpura, fever, vasculitis, interstitial nephritis, eosinophilia, photosensitivity. Extremely rare - severe anaphylactic or anaphylactoid reactions up to shock, which until now have been described only after intravenous administration.

From peripheral blood

Rarely - thrombocytopenia. In rare cases, leukopenia. In some cases, agranulocytosis, aplastic anemia or hemolytic anemia. Since some adverse reactions (such as changes in blood count, severe anaphylactic or anaphylactoid reactions, severe allergic skin reactions) under certain conditions can be life-threatening for patients, if any side effects occur, you should immediately report them to your doctor.

Indications

• edema syndrome in chronic heart failure;
• edema syndrome in chronic renal failure;
• acute renal failure, including that during pregnancy and burns (to maintain fluid excretion);
• edema syndrome in nephrotic syndrome (in nephrotic syndrome, treatment of the underlying disease is in the foreground);
• edema syndrome in liver diseases (if necessary,
  adjunct to treatment with aldosterone antagonists);
• arterial hypertension.

Contraindications

• renal failure with anuria (in the absence of response to furosemide);
• hepatic coma and precoma;
• severe hypokalemia;
• severe hyponatremia;
• hypovolemia (with or without arterial hypotension) or dehydration;
• pronounced disturbances in the outflow of urine of any etiology (including unilateral damage to the urinary tract);
• digitalis intoxication;
• acute glomerulonephritis;
• decompensated aortic and mitral stenosis, hypertrophic obstructive cardiomyopathy;
• increased central venous pressure (over 10 mm Hg);
• hyperuricemia;
• children under 3 years of age (solid dosage form);
• pregnancy;
• breastfeeding period.
• hypersensitivity to the active substance or to any of the components of the drug; Patients allergic to sulfonamides (sulfonamide antimicrobials or sulfonylureas) may be cross-allergic to furosemide.

With caution: arterial hypotension; conditions in which an excessive decrease in blood pressure is especially dangerous (stenotic lesions of the coronary and/or cerebral arteries); acute myocardial infarction (increased risk of developing cardiogenic shock), latent or manifest diabetes mellitus; gout; hepatorenal syndrome; hypoproteinemia, for example, in nephrotic syndrome, in which there may be a decrease in the diuretic effect and an increase in the risk of developing the ototoxic effect of furosemide, so dose selection in such patients should be carried out with extreme caution); disturbances in the outflow of urine (prostatic hypertrophy, narrowing of the urethra or hydronephrosis); pancreatitis, diarrhea, history of ventricular arrhythmia, systemic lupus erythematosus.

Features of application

Use during pregnancy and breastfeeding

Furosemide crosses the placental barrier, so it should not be prescribed during pregnancy. If, for health reasons, Lasix is ​​prescribed to pregnant women, then careful monitoring of the condition of the fetus is necessary.

During breastfeeding, furosemide is contraindicated. Furosemide suppresses lactation.

Use in children

Contraindication: children under 3 years of age (solid dosage form).

Special instructions

Before starting treatment with Lasix, the presence of pronounced disturbances in the outflow of urine, including unilateral ones, should be excluded.

Patients with partial obstruction of urine outflow require careful monitoring, especially at the beginning of treatment with Lasix.

During treatment with Lasix, regular monitoring of serum sodium, potassium, and creatinine concentrations is usually required, and particularly close monitoring should be carried out in patients at high risk of developing fluid and electrolyte imbalance in cases of additional loss of fluid and electrolytes (for example, due to vomiting, diarrhea, or intense sweating).

Before and during treatment with Lasix, it is necessary to monitor and, if occurring, correct hypovolemia or dehydration, as well as clinically significant disturbances in water-electrolyte and/or acid-base status, which may require short-term cessation of treatment with Lasix.

When treating with Lasix, it is always advisable to eat foods rich in potassium (lean meat, potatoes, bananas, tomatoes, cauliflower, spinach, dried fruits, etc.). In some cases, taking potassium supplements or prescribing potassium-sparing drugs may be indicated.

Some side effects (for example, a significant decrease in blood pressure and accompanying symptoms) may impair the ability to concentrate and reduce psychomotor reactions, which can be dangerous when driving or operating machinery. This especially applies to the period of starting treatment or increasing the dose of the drug, as well as to cases of simultaneous use of antihypertensive drugs or ethanol.

Lasix is ​​a drug with a diuretic effect, which is used for acute and chronic heart failure and kidney problems. The main active ingredient is . It is prescribed for noticeable tissue swelling. Lasix is ​​available in tablets and solution for injection. The form of use is chosen by the doctor when prescribing this medicine. Unauthorized use of such serious drugs leads to negative consequences.

Active ingredient, effect on the body

Active ingredient: Lasix

Instructions for use of Lasix are available in each package of the drug. It should be fully studied before you start using it so that you do not experience common adverse reactions and serious complications later. Furosemide, which is part of the drug, is an effective diuretic. The product fights tissue swelling when the excretory system of the human body cannot cope with its tasks. Such unpleasant symptoms occur in the following cases:

• Acute and chronic heart failure;
• Hypertension;
• Renal dysfunction;
• Liver failure.

The diuretic Lasix affects the excretory system, allows you to get rid of excess fluid in the body, due to which the patient’s condition significantly improves. During long-term use of the drug, additional medications must be prescribed that restore the water and electrolyte balance in the body. This category includes Asparkam, Panangin. These drugs contain potassium and magnesium, which are actively washed away when diuretics are used, so these two groups of drugs are always used together.

Indications for use of Lasix

The instructions for use of Lasix tablets contain a list of symptoms for which this drug is prescribed:

• Difficulty breathing;
• Pain in the chest area;
• Dizziness;
• Loss of consciousness;
• Disorientation in space.

If you know why Lasix is ​​prescribed, you should not self-medicate. This drug is used as part of emergency treatment when the patient is in critical condition. In order to speed up the effect of the drug, it is used in the form of injections and injected directly into a vein. Lasix in ampoules is very rarely used intramuscularly, because with this method of administration the substance does not act for a long time.

After the patient’s condition has stabilized, the doctor may recommend a full course of treatment using this drug, but in tablet form. Be sure to follow the advice of specialists, otherwise the exacerbation of the disease will not keep you waiting.

Due to excessive accumulation of fluid in the body, blood pressure always increases, so Lasix fights one of the root causes of hypertensive crises. The liquid presses on the vessels both from the inside and from the outside. Incorrect treatment or its complete absence is fraught with serious consequences - hemorrhages, falling into a coma and death.

Contraindications

Furosemide-based diuretics are not suitable for all patients. There is a list of absolute contraindications when the drug cannot be taken. If you are intolerant to the components of the drug or allergic reactions to furosemide, you should stop taking it.

If the body is dehydrated, taking a diuretic can have a detrimental effect. In acute renal failure, uncontrolled medication intake is also undesirable. A lack of potassium and magnesium in the body is a contraindication to the use of Lasix until the electrolyte balance is restored. When the level of these microelements reaches relatively stable levels, a diuretic can be used if this is still necessary.

Precomatose, comatose state, when there are disturbances in the excretory function of the liver and kidneys, it is prohibited to administer the drug intravenously, because it is unknown how the body will react to such therapy.

Some of the above contraindications are absolute, that is, taking Lasix is ​​generally prohibited for such patients. Other contraindications are temporary and restrictive. If the patient's condition is stabilized, a diuretic can be used under the constant supervision of medical personnel.

Features of the use of tablets and solution for injection

Forms of release of the drug

Lasix is ​​available in the form of tablets and solution for injection. This drug is usually first prescribed when the patient is in an acute critical condition. It can be removed by administering a dose of the drug intravenously. Then, when the patient’s condition is stabilized, it is recommended to take pills.

Intravenous injections are performed only by medical personnel. The fastest possible action and minimum negative consequences are possible when the drug is administered using a dropper slowly over 1-3 hours. In this case, the patient experiences a strong urge to urinate. It is imperative to prepare a hygienic vessel.

Instructions for using Lasix in ampoules are also available in each package, but the dosage and method of infusion in this case are determined by the doctor.

When is bolus administration required?

Bolus administration of the drug

Bolus administration of the drug is carried out intravenously, but quickly. A dropper is not used; the injection is given with a regular syringe. This administration technique is available to experienced medical personnel. A bolus is used if the patient is in critical condition. Rapid administration of the medication intravenously allows you to stabilize blood pressure and partially relieve swelling. The active substances immediately enter the bloodstream, bypassing the gastrointestinal tract. They quickly begin to act, the patient feels relief.

This injection technology is used only in extreme cases, because there is a risk of vein rupture and severe bleeding. The physician sensibly assesses the risks and possible consequences before using a bolus injection of the drug.

Dosage of the drug

Dosage of the drug

The maximum daily dose of Lasix for an adult is 1500 mg. But such dosages cannot be prescribed for a long time. Once the patient's condition has stabilized, furosemide intake is gradually reduced. The daily dose must be divided into several doses. Decisions regarding increasing or decreasing the dosage of the drug, as well as its discontinuation, are made only by the doctor, assessing the patient’s current condition and making predictions regarding the development of the disease in the absence of appropriate therapy or a change in treatment regimen. It is strictly prohibited to independently adjust the dosage of the drug prescribed by the doctor.

It is not advisable for young children to take furosemide-based medications. When treating heart and kidney failure in children, other safer drugs are used without an extensive list of adverse reactions.

Side effects and consequences of overdose

With long-term use of Lasix, the following adverse reactions occur:

• Electrolyte imbalance;
• Dry mouth;
• Dizziness;
• Confusion;
• Severe headache;
• Cramps.

Nausea, diarrhea, acute abdominal pain, and pancreatitis may develop. Overdose of the drug is possible. In this case, hearing impairment, complete loss of orientation in space, weakness, constant feeling of thirst, pallor and cyanosis of the skin, and uncontrollable vomiting occur.

If you notice one or more of the above symptoms, you should immediately call an ambulance. The patient is taken to the intensive care unit, where he undergoes gastric and intestinal lavage and restoration of water and electrolyte balance. At this stage, there is an active fight against dehydration. The fluid is infused intravenously. When nausea and vomiting pass, the patient is forced to drink a lot, but in small portions. Electrolyte solutions are used for these purposes.

Drugs based on furosemide

The price of Lasix in tablets or ampoules is low, but it varies in the pharmacy chain. If this drug is not available, you can use any other furosemide-based products. It is necessary to familiarize yourself with the list of excipients in the composition; they may differ. This is necessary to make sure that the patient does not have allergies or intolerance to all components of the composition.

Emergency doctors always have medications based on furosemide; they inject the medicine on calls to patients with severely elevated blood pressure.

The danger of self-medication

Lasix is ​​sold over the counter without a prescription, but this does not mean that patients can take this drug irresponsibly. Many consider it harmless and use it for the slightest swelling of tissues, but this medicine has many contraindications, adverse reactions and negative consequences if the rules of administration are not followed.

Self-prescribing furosemide medications is strictly prohibited. You can take Lasix only with a specific prescription from your doctor. He is obliged to write down the dosage regimen for each day, indicate the timing of use of the medicine. During treatment, water and electrolyte balance must be monitored. The drug is prescribed in combination with medications containing potassium and magnesium. It is not recommended to use it separately.

Can Lasix be used for weight loss?

Relatively recently, articles and advertising materials began to appear on the Internet recommending the use of Lasix in the fight against excess weight. They describe in detail how to take Lasix for weight loss and what positive effects can be expected from this process.

The basis of our body is liquid. With significant losses, weight also decreases. This is the basis of the principle of losing weight with the help of drugs based on furosemide. But women who uncontrollably use this method do not realize that they are losing water, not fat. The kilograms go away, but return with interest within a few weeks, the volumes change very little, and the ratio of fat and muscle mass remains the same.

You will never lose weight by taking Lasix, but will only make your health worse. If you take the drug uncontrollably, you can only achieve severe dehydration. He will then have to be treated in a hospital. Proper weight loss cannot be quick. Losing 8-10 kg per month is dangerous to health, and fat, not water, should disappear. Reviews about Lasix for weight loss are falsifications that cannot be trusted. There is no need to use methods that are hazardous to health, criticized by official medicine.