Increased synthesis of prothrombin in the liver occurs as a result of some injuries, when the body tries to stop excessive blood loss. Unfortunately, the well-functioning mechanism sometimes malfunctions, and an increase in prothrombin in the blood occurs when there is no danger of blood loss.

Situations like this lead to increased thrombosis, which can lead to stroke, heart attack or blockage of peripheral blood vessels.

Drugs called indirect anticoagulants, which include Fenilin. This drug has a pronounced cumulative effect and overcomes the hematic and histological barrier well.

The main property due to which the anticoagulation effect is achieved is to reduce the formation of certain blood clotting factors and prothrombin itself.

Instructions for use

The active compound Phenilin is metabolized primarily in the liver and excreted through the kidneys.

While in the body, this component of the drug is found in almost all tissues of the human body. As a result, Phenilin can change the functional component of internal organs, that is, influence their activity. All this requires taking into account many factors when prescribing medicine to patients. They are described in detail in the official instructions for use of the drug.

Release form and composition

The drug Phenilin is available in the form of white or creamy-beige tablets in the usual form for this form of medication - a flat cylinder with bevels.

The tablets contain active compound phenindione in an amount of 0.03 g per tablet, as well as a complex of additional components: starch, talc, lactose and citric acid.

The tablets are packaged in contour packs of 20 pieces each, or in opaque jars made of polymer material of 20 or 50 pieces each.

Video: "Pharmacology of anticoagulants"

Indications for use

• thrombophlebitis;
• thrombosis;
• myocardial infarction with thromboembolic complications;
• embolism of large vessels of internal organs;
• ischemic stroke.

In addition, the drug Phenilin is used to prevent thrombosis in the postoperative period (but only if there is a risk of thrombosis or thromboembolism).

Directions for use

Phenilin tablets are intended for oral administration, and the dosage of the drug depends on the patient’s index prothrombin at the time of calculation, as well as on the existing diagnosis and purpose of admission - prevention or treatment of the condition.

To maintain prothrombin levels in the blood(optimal indicators 50-40%) on the first day of use, the medicine is prescribed in a dosage of 4 to 6 tablets per day, divided into 3-4 doses, depending on the existing blood picture. On the second day of therapy, the dosage is slightly reduced - to 3-5 tablets. On the third day, the dosage is reduced to 1-2 tablets.

As a prophylactic if there is a risk of developing thromboembolism, the drug is prescribed in a dosage of 0.03 or 0.06 g per day. If it is necessary to take a large dose, it is divided into two doses.

For thrombosis in acute form, heparin is added to the treatment regimen described above. The dosage of the latter is calculated empirically, gradually increasing or decreasing the amount of the administered drug.

Stopping taking Phenilin is strictly prohibited. This should be done by gradually reducing the dosage of the medication.

Throughout the entire therapy, the patient should be under the supervision of a doctor who will monitor the amount of prothrombin in the blood, as well as other factors of its coagulation.

Drug interactions

When used together with other drugs, Phenylin can increase or decrease the effect on the body. This must be taken into account when prescribing the drug in combination with certain drugs.

The following drugs enhance the anticoagulant effect of Phenilin to varying degrees:

• preparations with salicylate;
• sulfa drugs;
• cimetidine;
• anabolic agents;
• narcotic analgesics;
• tricyclic antidepressants;
• glucocorticosteroid drugs;
• medications with hormones (especially androgens);
• saline solutions.

Preparations containing ascorbic acid, vitamin K, female sex hormones, diuretics, antacids and barbiturates can reduce the effectiveness of Phenilin.

Side effects

When taking the drug, unwanted symptoms may appear. Most often, the active ingredient in tablets has a negative effect on the liver, as a result of which the patient’s palms may turn yellow.

Also, some patients experience the occurrence of allergic dermatitis and stool disorders in the form of diarrhea. In rare cases, it is possible to develop a febrile state that occurs against a background of elevated body temperature.

If the recommended dosages are exceeded, the manifestations of the above disorders are aggravated. The risk of bleeding also increases significantly. Treatment of overdose is symptomatic. Patients are prescribed vitamins K and C, Vikasol and calcium chloride.

Contraindications

The use of the drug Phenilin can have an adverse effect on the body and, therefore, be dangerous in the presence of the following diseases and conditions:

• hemorrhagic diathesis;
• first trimester of pregnancy;
• severe dysfunction of the liver and kidneys;
• oncology;
• ulcerative lesions of the gastric or intestinal mucosa;
• inflammation of the pericardium.

Prescribe medication with extreme caution for pulmonary embolism in elderly patients, as well as during menstruation and in the period after childbirth.

During pregnancy

The drug is contraindicated for use in women at the initial stage of pregnancy, especially in the first third, as well as shortly before childbirth. During breastfeeding, you can take the medicine only after transferring the child to artificial feeding.

Storage conditions and periods

A dark and not too humid place with a temperature of up to 25 degrees Celsius is suitable for storing Phenilin tablets. It is important to ensure that the medicine is not available to young children and pets.

The period during which the tablets can be used is 2 years from the date of manufacture. After its expiration, it is recommended to dispose of the drug in its original packaging.

Price

Phenilin tablets belong to the category of drugs available to a wide range of consumers. It can be purchased for a fairly modest price (compared to other drugs with similar effects).

Cost in Russia

In Russian pharmacies, Phenilin can be purchased at a price from 139 to 172 rubles per pack of 20 tablets.

Cost in Ukraine

In Ukrainian pharmacies, a package of 20 tablets costs on average from 20 to 27 hryvnia.

Analogs

Phenilin tablets do not have many analogues, although the pharmaceutical industry produces enough indirect anticoagulants.

The medications closest to the drug described are:

and some others.

However, using them instead of Phenilin is strictly prohibited, since they have a different list of indications and contraindications, as well as modes of action on the hematopoietic system that are different from Phenilin.

Video: "Pharmacology of Warfarin"

The heart is the engine of the human body. Modern life, environmental disaster, unhealthy diet, as well as high levels of stress daily lead to disruption of the functioning of a vital organ.

In most cases, heart disease leads to a sharp deterioration in a person’s standard of living, less often to disability, and in severe situations to death.

To treat them, a cardiologist may prescribe a drug, for example, the drug Phenilin.

Phenylin is a drug that prevents blood clotting. How should it be taken correctly so that the product has only benefits?

There is a wide range of reviews on the Internet. They can be found in this article.

Instructions for use of this product

In this article you can find information about when exactly the drug can be prescribed, what composition it has, how the drug should be taken, what contraindications it has, what side effects can be identified, how the drug should be stored, and also with what drugs it should not be used in any case. The drug is not recommended to be taken, what actions should be taken in case of an overdose, and also in what form can it be produced?

In addition, here you can also find information such as price, as well as possible analogues.

Pharmacology

To begin to function in the human body, Phenilin must accumulate in the required concentration, therefore its effect does not appear immediately - it begins after 10 hours, and the maximum effect is achieved after a day or two.

The drug Phenilin is absorbed quite well from the gastrointestinal tract. Its further transformation occurs in the liver. It is excreted from the body through the kidneys.

For what conditions is the remedy prescribed?

This remedy can be prescribed:

1. For the treatment of thrombophlebitis or thrombosis;
2. For the prevention of myocardial infarction;
3. For embolic strokes.

In addition, the drug can be prescribed for blood clots after surgery.

How to take the product correctly?

Elderly patients should adjust the dosage.

The drug Finilin is prescribed orally to patients over 14 years of age (whose body weight is more than 45 kg). The drug should be taken after meals. The optimal dosage is selected individually in each case. The dosage is influenced by the severity of the disease, the individual characteristics of the patient’s body, nutritional characteristics and the treatment that the patient is already receiving.

Adults are prescribed 4-6 tablets on the first day. The dose is divided into 3-4 times. On the second day, the dosage is reduced to 3-5 days, then it should not exceed two tablets. The duration of receptions per day is several times.

In the first few days, adolescents should take 3-5 tablets in three or four doses, then the dosage is reduced to one or two tablets in one or two doses.

To prevent thromboembolic complications, the drug is prescribed in a dosage of one tablet, which should be taken once or twice a day.

The highest dosage for an adult: single - 50 mg, daily - 200 mg.

Compound

This product can be found in the form of white tablets with a creamy tint.

The product contains phenindione. Auxiliary components are components such as talc, milk sugar, starch, citric acid.

Combination of funds

When combined with ACTH, the anticoagulant effect of the drug Phenilin is enhanced.

When combined with dopyridamole, cases of increased bleeding were observed. This is due to a decrease in adhesiveness, as well as platelet aggregation under the influence of dopyridamole.

When combined with clofibrate, the anticoagulant effect of the drug is enhanced. When combined with liothyronine, the anticoagulant effect of phenindione is enhanced.

When combined with cimetidine, the anticoagulant effect of phenindione increases due to a slowdown in its metabolism in the liver under the influence of cimetidine, which is an inhibitor of liver enzymes.

When taken with ethylestrenol, the anticoagulant effect increases and the risk of bleeding increases.

Adverse reactions

Sometimes the patient's body may malfunction. As a result, the patient may experience symptoms such as:

1. Vomiting, nausea, diarrhea, constipation, toxic form of hepatitis. Sometimes a person may experience flatulence, bloating, and liver problems.
2. Arganulocytosis, leukopenia.
3. Impaired kidney function.
4. Sleep disturbance, headache.
5. Change in urine color, fever.
6. Eosinophilia, skin rash, sudden increase in body temperature, dermatitis, urticaria, skin peeling, itching.

If during treatment you begin to experience these conditions, then in this case you should stop taking this medication, because This drug may harm your health.

Overdose

If a person takes a medicine in a large dosage, the person may experience an overdose.

This condition is evidenced by such manifestations as depression, pain in the abdomen/back/chest, excitability, nausea, vomiting, constipation, diarrhea, bloating, flatulence, sleep disturbance, eosinophilia, hepatitis, disturbances in the liver, disturbances in the functioning of the kidneys , headache, as well as any other manifestations of an overdose.

For treatment, the stomach should be rinsed, and all measures should be taken to eliminate the symptoms that appear in a person.

Contraindications

1. Disturbances in the functioning of the kidneys and liver (if the disease is serious). If the lesion is mild, then you should not stop taking the drug.
2. Ulcerative lesions of the gastrointestinal tract, gastritis.
3. Malignant neoplasms.
4. Increased vascular permeability.

With increased caution, the drug can be prescribed for gynecological diseases, as well as erosion in the gastrointestinal tract.

Taking medication during pregnancy

If you still need to take this drug, the doctor can prescribe the drug in late pregnancy, but he must carefully monitor the patient.

When breastfeeding, it is also better to refrain from taking this drug, because. this is due to the fact that the drug has a negative effect on a small organism.

Moreover, if it is necessary to take the drug during this period of time, then it can only be carried out if natural feeding is abandoned.

Storage

The medicine should be placed in a room where the temperature does not exceed 25 degrees. It should be borne in mind that the chosen place should be sufficiently dark, cool, and also dry.

If you do not comply with these requirements, the service life of the medicine will be sharply reduced. The drug must be removed to a place where children and beloved pets will not have access under any circumstances.

Price

Prices may vary significantly in different countries. For example, we will consider two states - Ukraine and Russia.

The article presents average price data.

Price in Russia is 120 rubles.

In Ukraine for a package of this drug you will have to pay 65.49 hryvnia.

Analogs

Drugs with similar effects are drugs such as Plestasol, Sinkumar, Atrombone, Atherocard, Warfarin, Gedulin, Atrogrel, Acecardine, Diofindal, Agrelide, Pindion, Tromazal, Thrombozol, Phenindione, Trombantine, Phenylindandione and other drugs.

It is worth considering that all these drugs may have different effects on the body, as well as costs. That is why the selection of an analogue should only be carried out by a specialist.

Instructions for use:

Phenilin is an anti-clotting agent.

Pharmacological properties

Phenilin is part of the group of indirect anticoagulants.

According to the mechanism of action, it belongs to vitamin K antagonists. Competing with vitamin K, Phenilin blocks the enzyme K-vitamin reductase. Because of this, the synthesis of blood coagulation factors VII, IX, X and prothrombin in the liver is disrupted. A deficiency of coagulation factors disrupts the process of thrombus formation, reduces the content of lipids in the blood, and makes blood vessels more permeable.

To begin to work in the body, Phenilin must accumulate to a certain concentration, therefore its effect does not appear immediately - it begins after 8-10 hours, and the maximum effect is achieved after 24-30 hours.

Monitoring the anticoagulant effect of Phenilin is based on determining the prothrombin time in the coagulogram - PT; normally it is 11-14 seconds. To prevent venous thrombosis, it is enough to increase PT by 2 times, arterial by 3-4 times compared to the norm.

Phenilin is quickly and well absorbed from the digestive tract. Its transformation occurs in the liver. It is excreted from the body in the form of metabolites by the kidneys.

Release form

The drug is available in 30 mg tablets.

Indications for use of Phenilin

According to the instructions, the drug is used in those conditions where a long-term decrease in blood clotting is necessary. It is used to prevent and treat thrombosis, thrombophlebitis and thromboembolic complications (pulmonary embolism, etc.), as well as thrombosis in the postoperative period. Constant use of Phenilin is necessary if a person has mechanical prosthetic heart valves. The drug is used in complex anticoagulant therapy together with heparin.

Contraindications

It is necessary to take the medicine under control of blood clotting. If the prothrombin level is below 70% of normal, there is a high risk of bleeding. Phenilin is not prescribed for blood diseases associated with coagulation disorders (hemophilia, hemorrhagic diathesis), for severe renal failure, in the 1st trimester of pregnancy and for individual intolerance. It is recommended to use this remedy with caution in old age, with cancer, disorders of the kidneys and liver, with ulcers and erosions in the digestive tract, with anemia and gynecological diseases, in the early postpartum period, and with lactation. The drug should be discontinued 2 days before the start of menstruation.

Instructions for use of Phenilin

According to the instructions, the dose of the drug is selected according to the duration of prothrombin time, maintaining the prothrombin index at the level of 40-60%. On the first day, the loading dose is 120-180 mg orally in 3-4 doses, on the second day – 90-150 mg/day, then – under the control of PTT, 30-60 mg/day. The maximum daily dose of Phenilin is 200 mg.

While taking the drug, you should regularly monitor your coagulogram, thromboelastogram, platelet levels in the blood, and urine for possible hematuria.

Treatment with the drug should be discontinued gradually. Sometimes patients' palms turn yellow and their urine turns pink. In case of an overdose of Phenilin, vitamin K will be its antagonist; in acute cases it is administered parenterally.

Side effects of Phenilin

According to reviews, phenylin can cause nausea, diarrhea, headaches, fever, allergic reactions, toxic hepatitis, and hematopoietic disorders.

Long-term use sometimes provokes the development of hemorrhagic syndrome in the form of nasal, uterine, renal, gastrointestinal bleeding, hemorrhages in internal organs or muscles.

The tablet contains the active ingredient: phenindione .

Additional ingredients: milk sugar, citric acid, starch and talc.

Release form

Phenilin is available in tablets of 20 or 50 pieces per package.

Pharmacological action

The drug has anticoagulant action.

Pharmacodynamics and pharmacokinetics

The use of this drug affects coagulation and is an indirect anticoagulant. Its intake contributes to the development of hypoprothrombinemia, caused by impaired formation of prothrombin in the liver, reduces the formation of factors VII, IX and X. At the same time, Phenilin has a greater cumulative effect compared to neodicoumarin . As a result of internal administration, the concentration of blood coagulation factors decreases within 8-10 hours, the maximum effect is achieved after 24-30 hours.

The drug is characterized by rapid and complete absorption. The active component penetrates the histo-hematological barriers, accumulating in the tissues. occurs in the liver. The substance is excreted unchanged by the kidneys and.

Indications for use

The main use of Phenilin is treatment and prevention:

• , and thromboembolic complications caused by , embolic strokes and similar disorders;
• as well as preventing blood clots after surgical interventions.

Contraindications for use

The drug is not prescribed to patients with:

• initial prothrombin level up to 70%;
• hemorrhagic diathesis and other diseases associated with decreased blood clotting;
• dysfunction of the liver and kidneys;
• increased vascular permeability;
• ulcerative diseases of the gastrointestinal tract;
• pericarditis .

Side effects

When treated with Phenilin, there may be , , nausea , hepatitis . Also sometimes appears: , , problems with hematopoiesis, changes in skin and urine color.

Phenilin, instructions for use (Method and dosage)

These tablets are used orally. At the same time, the therapeutic regimen has certain features, so you need to take the medicine only as prescribed by your doctor. The initial daily dosage is usually 0.12-0.18 g taken 3-4 times a day, the next day the dose is reduced to 0.09-0.15 g, and then to 0.03-0.06 g. Further intake of tablets and dosage depends on the level of prothrombin in the blood.

The maximum single dosage is 0.05 g, and the daily dosage is 0.2 g.

In order to prevent thromboembolic complications, 1-2 single doses of 0.03 g per day are recommended.

Treatment of acute requires additional heparin. This requires strict medical supervision and a mandatory systematic study of the content of prothrombin in the blood and other blood clotting factors. Stop treatment gradually.

Overdose

In cases of overdose, an exacerbation of symptoms related to side effects is possible. The main antagonists of Phenilin include vitamin K .

Treatment includes mandatory drug withdrawal, immediate administration intramuscular, purpose vitamin P or , , and carrying out other symptomatic therapy.

Interaction

The combination of Phenilin and , salicylates, sulfonamides, Qi-methidine may strengthen anticoagulant effect . At the same time, they can enhance the effectiveness of the drug itself anabolics, , Allopurinol , narcotic, tricyclic antidepressants , androgens , gluco-corticosteroids, Disopyramide, Diazoxide, Clofibrate,

It is imperative to eliminate these diseases in time, otherwise much more serious consequences may arise. One of the effective drugs that is used to treat various vein diseases is Phenilin. It has long established itself as an effective remedy for treating vein blockage, inflammation, etc.

This is a synthetic type drug that prevents increased blood clotting. The instructions indicate that this is indirect action. The main component of the drug is phenindione.

It is due to it that blood clotting is reduced, blood clots are resolved, inflammation and other unpleasant sensations in the legs go away.

Composition and release form

1 tablet of the drug contains the following components:

• main component – ​​phenindione 0.03 grams;
• additional components - milk sugar, starch powder, talc, citric acid.

The tablets are white, sometimes with a creamy tint. The shape of the tablets is cylindrical.

Available in cardboard packages with blisters and glass jars.

Pharmaceutical properties of the drug

The drug Phenilin is part of a group of anticoagulants that have an indirect effect (drugs that slow down effect on blood clotting).

The active component, phenindione, causes hypoprothrombinemia, which is associated with problems in the formation of prothrombin in the liver.

It also leads to a decrease in the formation of VII, IX, X blood coagulation factors, a decrease in the level of plasma tolerance to heparin, the presence of lipid components in the blood composition and an increase in the permeability of vascular walls.

The effect of the drug begins within 8-10 hours and reaches its maximum concentration level 24-30 hours after taking the drug.

This product has fast and complete absorption. The main substance of the drug passes through histo-hematological barriers and accumulates in tissues. The metabolic process occurs in the liver. The substance is excreted through the kidneys unchanged and in the form of metabolites.

Indications for use

Phenilin is recommended to be taken during periods of increased blood clotting; it has an inhibitory effect on blood clotting. It is often prescribed during treatment and for the prevention of thrombotic diseases. It is worth understanding that in case of thrombosis, this drug is taken for a long time.

In addition, according to the instructions, this medicine must be taken for the treatment and prevention of conditions:

This remedy can also be taken in the postoperative period to prevent various complications.

When not to prescribe a remedy

According to the instructions, the drug should not be taken in the following situations:

• if there is individual intolerance to the constituent components of the drug;
• if the initial prothrombin content is less than 70%;
• during various diseases during which decreased blood clotting is observed;
• in cases of high vascular permeability;
• if there are disturbances in the functioning of the liver and kidneys;
• during pericarditis;
• for malignant neoplasms;
• if there is a peptic ulcer of the stomach, duodenum and other erosive and ulcerative lesions of the gastrointestinal tract;
• should not be taken during pregnancy and lactation.

Instructions for use

The medicine is prescribed to be taken orally according to the following scheme:

• on the first day– per day you need to take from 0.12 to 0.20 grams, approximately 3-4 doses;
• on the second day– per day from 0.9 to 0.15 grams, 2-3 doses;
• on the third day and subsequent days– per day from 0.03 to 0.06 grams, depending on the level of prothrombin in the blood.

After this, depending on the patient’s condition and depending on the individual dynamics of the decrease in prothrombin in the blood, the dosage of Phenilin is reduced to 0.01-0.02 at a time. On average, the duration of treatment is from 2 to 3 weeks.

How to take for thrombosis and thrombophlebitis

When and the drug should be taken in a dose of 0.003 to 0.005 grams at a time. You need to take tablets 2 times a day.

The duration of this treatment is 2 days. After this, the dosage is reduced - 0.002-0.001 grams per dose, also taken 2 times a day.

It is taken until the disease disappears completely - 2-3 weeks.

How to take during thromboembolic complications

During preventive treatment of thromboembolic complications, it should be taken in a dosage of 0.002 to 0.03 grams per dose, 2 times a day. Should be taken within 2-3 weeks.

How to take for acute thrombosis

During acute thrombosis, you need to take Phenylin together with. Dosages are the same as for the usual form of thrombosis. Maximum dosage for oral administration: single - 0.05 grams, daily - 0.20 grams.

During treatment, the level of prothrombin in the blood composition should not be reduced below 40%.

Side effects

The following side effects may occur while taking the drug:

Interaction with other drugs

If taken concomitantly with ACTH, the anticoagulant effect may be increased.

When taken together with Dipyridamole, cases of increased bleeding are described. This may be due to a decrease in platelet adhesion and aggregation under the influence of Dipyridamole.

When taken together with Clofibrator, the anticoagulant effect increases.

During simultaneous use with Liotronin, Miconazole, Cimetidine, Ethylestrinol, an increase in the anticoagulant effect of Phenilin occurs.

Practical application experience

Having studied the reviews of doctors and patients who take Phenylin, certain conclusions can be drawn.

The drug Phenilin is a good remedy for the prevention of increased blood clotting. In addition, its use during thromboembolic diseases gives good results. Many of my patients, after treatment with this remedy, note that they feel much better. But before taking the medicine Phenilin, you should still consult a doctor, he will be able to conduct an examination and prescribe the correct treatment.

Phlebologist

Phenilin is a good drug for both the prevention and treatment of thrombosis and thromboembolism. It helps with blockage of veins and blood vessels, relieves inflammation, and also prevents increased blood clotting.

But still, do not forget about contraindications and side effects. Therefore, before you start taking this remedy, be sure to consult your doctor.

Vascular surgeon

I have always suffered from thrombophlebitis, it simply did not give me peace. What were these swelling and pains worth? I tried everything I could to treat this disease, but the effect was always temporary.

After the examination, the doctor prescribed me to take the drug Phenilin. I took it for 2 weeks according to the instructions. After treatment I noticed good improvements. After the examination, the doctor noted that my blood vessels and veins became clean, the inflammation went away, and the pain disappeared.

But the drawback is that there are many contraindications, so this remedy is not suitable for everyone!

Svetlana, 54 years old

When I noticed swelling in my legs and severe pain, I immediately went to the doctor. After examination, it was discovered that I had thrombosis and thrombophlebitis.

The doctor prescribed me to take Phenilin along with heparin. I took the drug according to the instructions for 3 weeks. Already in the second week I noticed noticeable changes - the swelling went away, it became smaller, it went away. And at the end of the treatment, these symptoms completely went away and do not bother me to this day. It's already been a year since the treatment, and my legs are like new!

Marina, 42 years old

Cost of the drug

The cost of a package with 20 tablets is about 75-80 rubles, the cost of package No. 10 is from 40 to 50 rubles, the price of a package of Phenilin with 30 tablets is from 110 to 130 rubles.

Analogues of the drug are available: