Ascorbic acid (5%) Ascorbic acid. Ascorbic acid - instructions for use. The benefits of ascorbic acid for the body

Ascorbic acid is a well-known vitamin preparation, which, probably, every person used.

What is the composition and form of release of the drug ascorbic acid?

Ascorbic acid is a drug that is produced in the form of a dragee, while it contains 50 mg of vitamin C. The product is available in polymer jars, where there can be 100 or 200 pieces of dragee.

It must be stored in a dry place away from light. The shelf life is one and a half years, after which it is not recommended to use these vitamins. You can buy them at any pharmacy in the over-the-counter department.

What is the effect of the vitamin ascorbic acid?

Ascorbic acid enters the human body only from the outside, therefore, with food. With a daily requirement of 90 mg, the symptoms of beriberi or hypovitaminosis will quickly disappear.

Vitamin C takes an active part in many biochemical processes, in particular, ascorbic acid is a cofactor in hydroxylation reactions, participates in the oxidative processes of lysine chains with the formation of hydroxytrimethyllysine, and takes part in dopamine metabolism.

In addition, it also enhances the action of amidating enzymes that are involved in the formation of oxytocin and cholecystokinin. Vitamin C is also involved in the formation of hormones in the adrenal cortex.

The main role of ascorbic acid in tissues is the direct participation in the synthesis of collagen, bones, and capillary endothelium. Vitamin C has a general stimulating effect on the body of a non-specific nature, in addition, it increases resistance to certain infections, and also improves regenerative processes.

What are the indications for use of ascorbic acid?

Ascorbic acid can be used in many conditions, some of which I will list:

As a prevention and treatment of both beriberi and hypovitaminosis;
With an unbalanced diet;
The period of intensive growth of the body;
Artificial feeding;
The drug is also prescribed in the presence of a burn disease;
It is recommended to take the remedy with increased physical exertion, as well as with mental overstrain;
With nicotine addiction;
With alcoholism;
During the recovery period after suffering serious illnesses;
stressful conditions;
Pregnancy;
chronic infections;
Fever on the background of acute respiratory infections;
Postoperative period;
Intoxication with drugs containing iron.

Under all these conditions, the use of ascorbic acid will be justified.

What are the contraindications for the use of the drug ascorbic acid?

Among the contraindications to taking this vitamin include the presence of thrombophlebitis in history, as well as a tendency to thrombosis. In addition, you can not take dragees with hypersensitivity, with diabetes mellitus, with fructose intolerance, as well as with glucose-galactose malabsorption.

With caution, vitamin C should be treated in the presence of progressive malignant neoplasms, with hyperoxaluria, leukemia, with renal failure, with sideroblastic anemia.

What is the dosage and use of ascorbic acid?

The drug ascorbic acid instructions for use recommends taking after eating inside, for prevention, one, two tablets per day, for treatment, you can increase the dosage to 10 pieces, after consulting with the doctor.

Is it possible to overdose when taking the drug ascorbic acid?

If you accidentally overdose the drug, you can feel heartburn, diarrhea, hemolysis, urine will become reddish, and urination will be difficult, all these symptoms can appear when taking more than one gram of vitamin C per day. In this case, forced diuresis should be carried out in order to remove excess ascorbic acid from the body.

What are the side effects of vitamin ascorbic acid?

If side effects appear while taking the drug, then it is recommended to temporarily stop using it until the condition normalizes, and be sure to seek the advice of a doctor.

From the side of the nervous system: there is a sleep disturbance, a headache joins, there is a feeling of fatigue, increased excitability may be noted.

The digestive system may also react to the use of the vitamin, causing side effects such as stomach cramps, nausea and vomiting, and diarrhea.

Laboratory changes: hyperglycemia, glucosuria, hyperoxaluria, thrombocytosis, neutrophilic leukocytosis, hyperprothrombinemia, erythropenia, and hypokalemia.

From the side of the heart: thrombosis, increased blood pressure, microangiopathy, development of myocardial dystrophy.

Other manifestations: hypovitaminosis, skin rash, sensation of heat, anaphylactic shock, with prolonged use, sodium retention may occur, the exchange of zinc and copper is disturbed.

special instructions

It is worth knowing that ascorbic acid stimulates the synthesis of corticosteroid hormones, therefore, it is recommended to monitor blood pressure and kidney function. With prolonged use of vitamin C, pancreatic function may be inhibited.

If the patient's body has an increased iron content, in this situation, vitamin C should be used in minimal dosages, after consulting with the doctor.

What are the analogues of the drug ascorbic acid?

Ascorbic acid analogues are as follows: Ascovit, Ascorbic acid with sugar, Ascorbic acid tablets 0.025 g, Vitamin C 500, Vaginorm-S, Plivit C, Rostvit, Cevicap, and some other vitamin preparations.

Conclusion

Ascorbic acid, the use of which is considered harmless by the layman, does not cause the same mood among all doctors. Therefore, before using vitamin C, you need to consult a doctor; you should not arbitrarily use it in uncontrolled dosages.

Ascorbic acid, or vitamin C, has strong restorative properties. Belongs to the group of water-soluble vitamins. Participates in redox processes, regulation of carbohydrate metabolism, affects the metabolism of aromatic amino acids, the metabolism of thyroxine, the biosynthesis of catecholamines, steroid hormones and insulin; necessary for blood coagulation, collagen and procollagen synthesis, regeneration of connective and bone tissue. Normalizes capillary permeability. Promotes the absorption of iron in the intestine and takes part in the synthesis of hemoglobin. Increases nonspecific resistance of the body, has antidote properties.
Vitamin C deficiency in food leads to the development of hypo- or avitaminosis C, since this vitamin is not synthesized in the body.

Indications for the use of the drug Ascorbic acid

Diseases that require additional administration of vitamin C: for the prevention and treatment of scurvy, for bleeding (uterine, pulmonary, nasal, hemorrhagic diathesis, bleeding that occurs during radiation sickness), for various intoxications and infectious diseases, nephropathy of pregnant women, Addison's disease, overdose anticoagulants, bone fractures and long-term non-healing wounds, dystrophy, reduction diets, during convalescence, pregnancy and lactation, with increased mental and physical stress, as well as for non-specific prevention of infectious diseases.

The use of the drug Ascorbic acid

Inside, in / m and in / in. Adults are prescribed orally for prophylactic purposes at 100-300 mg / day, for therapeutic purposes - at 600-2000 mg / day in 3 divided doses. For children of the 1st year of life who are bottle-fed, for prophylactic purposes, 30-50 mg / day is prescribed; from 2 to 18 years - 100-200 mg / day. For therapeutic purposes, children under the age of 3 years - 300-500 mg / day; 4-18 years - 500-1000 mg / day in 2-3 doses. During pregnancy and lactation - 300 mg / day for 10-15 days, then - 100 mg / day.
Parenterally administered as a solution of sodium salt (sodium ascorbate). Therapeutic doses for adults are 1 ml of 10% or 1-3 ml of 5% solution per day. Children are prescribed 1-2 ml of 5% solution. The duration of treatment is determined individually, taking into account the nature of the pathological process and the effectiveness of therapy.

Contraindications to the use of the drug Ascorbic acid

Hypersensitivity to ascorbic acid.

Side effects of the drug Ascorbic acid

Allergic reactions, hypervitaminosis C; intake in a dose of more than 1 g / day can cause heartburn, diarrhea, crystalluria and the formation of urate and / or oxalate stones in the kidneys and urinary tract.

Special instructions for the use of the drug Ascorbic acid

Be wary appoint patients with hypercoagulability, thrombophlebitis and a tendency to thrombosis, as well as diabetes. In case of urolithiasis, the daily dose of ascorbic acid should not exceed 1 g. When using ascorbic acid in high doses, it is necessary to control kidney function and blood pressure levels, as well as pancreatic function. a lack of vitamin C in the diet of pregnant women can be dangerous for the fetus, but its use in high doses during pregnancy can also adversely affect the development of the fetus. Ascorbic acid passes into breast milk, therefore, during breastfeeding, vitamin C should be used under medical supervision.

Interactions of the drug Ascorbic acid

The absorption of vitamin C is reduced with the simultaneous use of oral contraceptives, the use of fresh fruit or vegetable juices, alkaline drinks. Ascorbic acid when taken orally increases the absorption of penicillin, iron, reduces the effectiveness of heparin and indirect anticoagulants, increases the risk of developing crystalluria in the treatment of salicylates.

Overdose of the drug Ascorbic acid, symptoms and treatment

With prolonged use in high doses, inhibition of the function of the insular apparatus of the pancreas, impaired renal function, and increased blood pressure are possible.

List of pharmacies where you can buy Ascorbic acid:

Saint Petersburg

Few people know about the benefits of nicotinic or succinic acids. But even small children have heard about vitamin C, or about “ascorbic acid”.

It is no coincidence that ascorbic acid enjoys the widest popularity. To a large extent, due to the active promotion of its antioxidant properties, the ability to strengthen the immune system and serve as a prevention of colds.

Approximately on such a list of useful properties, the knowledge of an ordinary consumer about ascorbic acid usually ends. And the fact that its improper use is fraught with unpleasant consequences is even less known to the inhabitants.

Let us dwell on the properties of vitamin C and try to figure out why the body needs it. Exactly how much, in what doses and how it is necessary and how you can use ascorbic acid in order to get the least harm from this and as much benefit as possible. Including - to protect yourself from the devastating effects of urbanization and poor ecology and prevent premature aging.

Proper intake of ascorbic acid can significantly improve health and even serve as a prevention of cancer: cancer of the esophagus, bladder, intestines.

Lack of vitamin C, or ascorbic acid, provokes frequent colds, infectious diseases. It can cause a state of depression, emotional imbalance. Poor and prolonged wound healing, fatigue can also indicate a lack of ascorbic acid. In young children, its deficiency can provoke improper formation of the bones of the skeleton. With a strong deficiency, the development of such a serious illness as scurvy is possible.

Our body cannot produce ascorbic acid on its own, so there are only two ways to meet its needs for this vitamin:

Make sure you get your daily dose through food.
Use pharmaceutical preparations of ascorbic acid.

Daily doses of ascorbic acid

The usual daily dose, due to the body's need for vitamin C, is from 0.05 g to 100 mg. But it increases significantly with increased stress, hard physical labor, mental stress, emotional disorders, infectious diseases, pain, during pregnancy.

For the purpose of prevention for internal use:

The dose for adults is from 50 to 100 mg per day (1-2 tablets of 0.05 g each).

With a deficiency of vitamin C in children, they are usually prescribed 0.05-0.1 g (1-2 tablets) for a single dose. It is recommended to repeat it two or three times.

Maximum doses of ascorbic acid

For adults: single dose - no more than 200 mg, daily - no more than 500 mg.

For children under 6 months - 30 mg per day. No more than 35 mg per day - a dose for babies aged 6 months to a year. From the age of one to three years, the dosage of the vitamin rises to 40 mg. From 4 years to 10 years of age - 45 mg; and 50 mg for children 11 to 14 years of age.

The use of ascorbic acid during pregnancy

In the II-III trimesters, a pregnant woman should receive at least about 60 mg of ascorbic acid per day.

During pregnancy and during lactation, a woman needs sufficiently large doses of ascorbic acid - up to 300 mg (6 tablets) can be taken per day.

Overdose and its consequences

When taking excessively high doses of ascorbic acid for a long period - more than 1 g per day - side effects may occur:

Headache;
Nausea, vomiting, diarrhea, gastritis;
Malfunctions of the pancreas;
Kidney damage;
Decreased capillary permeability, increased blood clotting;
The threat of termination of pregnancy;
allergic reactions;
Increased excitability of the central nervous system;
Violation of metabolic processes;
Other disorders.

If any unpleasant symptoms appear, you should immediately stop taking ascorbic acid.

Taking too high doses during pregnancy can pose a threat to the health of the child. And in a pregnant woman - to provoke a miscarriage.

That dose of the vitamin, which does not have time to be absorbed by the body, is excreted by the kidneys in its pure form. And that overburdens them. One of the most terrible consequences is the formation of stones.

If any unpleasant symptoms appear, you should immediately stop taking ascorbic acid. It is necessary during treatment with ascorbic acid to control blood pressure and the state of the pancreas.

Ascorbic acid preparations are taken after meals.

Everyone needs vitamin C, especially pregnant and breastfeeding women and the elderly. In heavy smokers and alcohol abusers, the need for it also increases due to irrational spending.

Vitamin C is vital for good health. But its reserves are not reserved in the body. They must be replenished daily. As an alternative to pharmaceutical preparations, there is a wonderful natural remedy for the prevention of hypovitaminosis - an infusion of rose hips. A glass of vitamin drink a day - and your body is ready to repel unpleasant attacks!

One dragee contains

active substance - ascorbic acid (vitamin C) 50 mg,

excipients - sucrose (sugar), starch syrup, wheat flour, talc, food flavor "Lemon", sunflower oil, beeswax.

Description

Spherical dragee from white to light cream color

Pharmacotherapeutic group

Vitamins. Ascorbic acid in its purest form. Vitamin C.

ATX code A11GA01

Pharmacological properties

Pharmacokinetics

Absorbed in the small intestine. With an increase in dose to 200 mg, up to 140 mg (70%) is absorbed; with a further increase in dose, absorption decreases (50-20%). Communication with blood plasma proteins -25%. Diseases of the gastrointestinal tract (gastric ulcer and duodenal ulcer, constipation or diarrhea, helminthic invasion, giardiasis), the use of fresh fruit and vegetable juices, alkaline drinking reduce the absorption of ascorbonate in the intestine.

The concentration of ascorbic acid in the blood plasma is normally approximately 10-20 mcg / ml, the reserves in the body are about 1.5 g when taking daily recommended doses and 2.5 g when taking 200 mg / day. The maximum concentration (Tmax) after oral administration is 4 hours. Easily penetrates into leukocytes, platelets, and then into all tissues; the highest concentration is achieved in the glandular organs, leukocytes, liver and lens of the eye; deposited in the posterior pituitary gland, adrenal cortex, ocular epithelium, cells of the seminal glands of the ovaries, liver, spleen, pancreas, lungs, kidneys, intestinal wall, heart, muscles, thyroid gland; crosses the placenta. The concentration of ascorbic acid in leukocytes and platelets is higher than in erythrocytes and in blood plasma. In deficient conditions, the concentration of ascorbic acid in leukocytes decreases later and more slowly, and therefore is considered as a more reliable criterion for assessing deficiency than the concentration of ascorbic acid in blood plasma. It is metabolized mainly in the liver, into deoxyascorbic and then into oxaloacetic and diketogulonic acids. It is excreted by the kidneys, through the intestines, with sweat, breast milk in the form of unchanged ascorbate and metabolites. With the appointment of high doses, the rate of excretion increases dramatically. Smoking and drinking ethanol accelerates the destruction of ascorbic acid (transformation into inactive metabolites), sharply reducing its reserves in the body.

Excreted during hemodialysis.

Pharmacodynamics

Ascorbic acid is a vitamin remedy that is not formed in the human body, but comes only with food. Participates in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, in the synthesis of steroid hormones; increases the body's resistance to infections, reduces vascular permeability, reduces the need for vitamins B1, B2, A, E, folic acid, pantothenic acid. Participates in the metabolism of phenylalanine, tyrosine, folic acid, norepinephrine, histamine, iron, utilization of carbohydrates, synthesis of lipids, proteins, carnitine, immune reactions, hydroxylation of serotonin, enhances the absorption of non-heme iron. It has anti-aggregate and pronounced antioxidant properties.

Maintains the colloidal state of the intercellular substance and normal capillary permeability. Regulates immunological reactions (activates the synthesis of antibodies, the C3 component of complement, interferon), promotes phagocytosis, increases the body's resistance to infections. It inhibits the release and accelerates the degradation of histamine, inhibits the formation of prostaglandins and other inflammatory mediators.

Indications for use

Prevention, treatment of hypo- and avitaminosis of vitamin C

With an increased need for vitamin C in the body during the period

active growth in children, pregnancy, breastfeeding

With increased physical and mental stress, overwork, stressful conditions

During the recovery period after a long and severe illness

Dosage and administration

Inside, as a preventive measure 50 mg - 100 mg (1 - 2 tablets) per day; during pregnancy and lactation - 300 mg for 10-15 days (3 tablets), then - 100 mg (2 tablets) per day, children from 6 years and older - 50 mg - 100 mg (1 - 2 tablets) per day day.

For therapeutic purposes: adults 50 mg-100 mg (1-2 tablets) 3-5 times a day, children from 6 years of age 50 mg-100 mg (1-2 tablets) 2-3 times a day.

The duration of treatment depends on the nature and course of the disease, prescribed by the doctor.

Side effects

Headache, feeling tired

With prolonged use of large doses - increased excitability

CNS, sleep disturbance

Irritation of the mucosa of the gastrointestinal tract, nausea, vomiting,

diarrhea, stomach cramps

Increased blood pressure, the development of microangiopathy

Inhibition of the function of the insular apparatus of the pancreas

(hyperglycemia, glucosuria)

Decreased capillary permeability and deterioration of tissue trophism, thrombosis when taking high doses

Allergic reactions: skin rash, rarely - anaphylactic shock

Contraindications

Hypersensitivity to the components of the drug

Thrombophlebitis

Tendency to thrombosis

Diabetes

Children's age up to 6 years

Increased blood clotting

Progressive malignant diseases

Hyperoxalaturia

kidney failure

Hemochromatosis

Thalassemia

Glucose-6-phosphate dehydrogenase deficiency

Hyperoxaluria and the formation of urinary stones from calcium oxalate, damage to the glomerular apparatus of the kidneys

Thrombocytosis, hyperprothrombinemia, erythropenia

Drug Interactions

Increases the concentration in the blood of salicylates (increases the risk of crystalluria), ethinylestradiol, benzylpenicillin and tetracyclines, reduces - oral contraceptives. Reduces the anticoagulant effect of coumarin derivatives. Improves intestinal absorption of iron preparations. Preparations of the quinoline series, calcium chloride, salicylates, corticosteroids with prolonged use deplete vitamin C reserves.

Acetylsalicylic acid (ASA), oral contraceptives, fresh juices and alkaline drinks reduce absorption and assimilation.

Increases the overall clearance of ethanol, which, in turn, reduces the concentration of ascorbic acid in the body.

Barbiturates and primidone increase the excretion of ascorbic acid in the urine.

Reduces the therapeutic effect of antipsychotropic drugs (phenothiazine derivatives), tubular reabsorption of amphetamine and tricyclic antidepressants.

special instructions

In the treatment of large doses of ascorbic acid, it is necessary to monitor kidney function, blood pressure (BP) and pancreatic function. Ascorbic acid, as a reducing agent, can distort the results of various laboratory tests (blood glucose, bilirubin, transaminase activity).

In patients with high iron content in the body, ascorbic acid should be used in minimal doses.

Instructions for use

Attention! The information is provided for informational purposes only. This manual should not be used as a guide to self-medication. The need for appointment, methods and doses of the drug are determined solely by the attending physician.

general characteristics

The composition of the medicinal product:

active substance: ascorbic acid;

1 dragee contains ascorbic acid, in terms of 100% substance 50 mg;

Excipients: sugar, starch syrup, talc, yellow wax, orange flavor, light mineral oil, quinoline yellow dye (E 104).

Dosage form. Dragee.

Yellow dragee. It should be spherical in appearance. The surface of the dragee should be uniform in color.

Pharmacotherapeutic group

Ascorbic acid preparations ( vitamin (vitamins- organic substances formed in the body with the help of intestinal microflora or supplied with food, usually vegetable. Necessary for normal metabolism and life) WITH). Vitamin C. ATC code A11G A01.

Pharmacological properties

Ascorbic acid is involved in redox reactions, metabolism (Metabolism- the totality of all types of transformations of substances and energy in the body, ensuring its development, vital activity and self-reproduction, as well as its connection with the environment and adaptation to changes in external conditions) carbohydrates (Carbohydrates- one of the main components of cells and tissues of living organisms. They provide all living cells with energy (glucose and its reserve forms - starch, glycogen), participate in the body's defense reactions (immunity). Of the food products, vegetables, fruits, and flour products are the richest in carbohydrates. Used as drugs (heparin, cardiac glycosides, some antibiotics). The increased content of certain carbohydrates in the blood and urine is an important diagnostic sign of certain diseases (diabetes mellitus). Daily human need for carbohydrates is 400-450 g), tyrosine, gland (glands- organs that produce and secrete specific substances that are involved in various physiological functions and biochemical processes of the body. Endocrine glands secrete their metabolic products - hormones directly into the blood or lymph. External secretion glands - on the surface of the body, mucous membranes or in the external environment (sweat, salivary, mammary glands)), the conversion of folic acid to folinic acid, blood clotting, the formation of steroid hormones (Hormones- biologically active substances produced in the body by specialized cells or organs (endocrine glands) and have a targeted effect on the activity of other organs and tissues), collagen (Collagen- fibrillar protein, which forms the basis of the connective tissue of animals (tendon, bone, cartilage) and ensures its strength) and procollagen, tissue regeneration, permeability regulation capillaries (capillaries- the smallest vessels penetrating organs and tissues. Connect arterioles to venules (the smallest veins) and close the circle of blood circulation), synthesis lipids (Lipids- an extensive group of natural organic compounds, including fats and fat-like substances. Found in all living cells. They form the energy reserve of the body, participate in the transmission of a nerve impulse, in the creation of water-repellent and thermal insulation covers, etc.) and proteins (Squirrels- natural high-molecular organic compounds. Proteins play an extremely important role: they are the basis of the life process, participate in the construction of cells and tissues, are biocatalysts (enzymes), hormones, respiratory pigments (hemoglobins), protective substances (immunoglobulins), etc.), processes of cellular respiration.

Vitamin C helps to increase the body's resistance to infections and adverse environmental influences.

Ascorbic acid has antidote properties. Promotes absorption (Absorption- the process by which a drug enters the blood vessels from the site of administration) iron in the intestine and is involved in the synthesis of hemoglobin.

After oral (oral- the route of administration of the drug through the mouth (per os)) taking ascorbic acid is rapidly absorbed in the small intestine, its maximum concentration in plasma (Plasma- the liquid part of the blood, which contains formed elements (erythrocytes, leukocytes, platelets). Various diseases (rheumatism, diabetes mellitus, etc.) are diagnosed by changes in the composition of blood plasma. Medicines are prepared from blood plasma blood is determined after 4-7 hours. From the blood plasma, it penetrates primarily into the elements of the blood ( leukocytes (Leukocytes- colorless blood cells of humans and animals that absorb bacteria and dead cells and produce antibodies. Includes granulocytes, lymphocytes and monocytes), platelets (platelets- blood cells involved in the process of blood clotting. With a decrease in their number - thrombocytopenia - there is a tendency to bleeding), erythrocytes (red blood cells- red blood cells containing hemoglobin. They carry oxygen from the lungs to the tissues and carbon dioxide from the tissues to the respiratory organs. Produced in red bone marrow. 1 mm3 of a healthy person's blood contains 4.5-5.0 million erythrocytes)), then to all tissues. Plasma protein binding is about 25%.

Ascorbic acid is reversibly oxidized with the formation of dihydroascorbic acid, a part is metabolized with the formation of ascorbate-2-sulfate and oxalic acid (Oxalic acid- a widespread dicarboxylic acid that enters the body with food, and is also formed as the end product of the oxidative deamination of glycine; excreted in urine as calcium oxalate) which is excreted in the urine. Excess ascorbic acid is excreted from the body in the urine unchanged.

Indications for use

Prevention and treatment of vitamin C deficiency. Ensuring the body's increased need for vitamin C during growth, pregnancy or lactation; with increased physical and mental stress, with infectious diseases and intoxications (Intoxication- poisoning of the body with toxic substances), hemorrhagic diathesis (Hemorrhagic diathesis- hereditary or acquired pathology, characterized by increased bleeding), in the complex therapy (Therapy- 1. The field of medicine that studies internal diseases, one of the oldest and main medical specialties. 2. Part of a word or phrase used to indicate the type of treatment (oxygen therapy\; hemotherapy - treatment with blood products)) bleeding (nose, pulmonary, uterine); with radiation sickness, Addison's disease, overdose anticoagulants (Anticoagulants- drugs that reduce blood clotting), with soft tissue injuries and infected wounds that heal slowly, bone fractures.

Contraindications

Hypersensitivity to the components of the drug, thrombosis, a tendency to thrombosis, thrombophlebitis (Thrombophlebitis- a disease of the veins characterized by inflammation of the venous wall and thrombosis. The occurrence of thrombophlebitis is preceded by inflammation of the vein - phlebitis and periphlebitis), diabetes mellitus, severe kidney disease, urolithiasis disease (Urolithiasis disease-formation of kidney stones(when used over 1 g per day), fructose intolerance, children under 4 years of age.

Dosage and administration

The drug is taken orally, after a meal.

For prevention, adults and children from 14 years old should take 1-2 tablets (50-100 mg) per day, children from 4 to 14 years old - 1 tablet (50 mg) per day.

Therapeutic doses for children from 14 years of age and adults are 1-2 tablets (50-100 mg) 3-5 times a day, for children from 4 to 7 years - 1-2 tablets (50-100 mg) 2-3 times a day, at the age of 7-10 years - 2 tablets (100 mg) 2-3 times a day, at the age of 10-14 years - 2-3 tablets (100-150 mg) 2-3 times a day.

Pregnant women and women after childbirth and with a low level of vitamin C in breast milk should take 6 tablets (300 mg) per day for 10-15 days, then for prevention, 2 tablets (100 mg) per day for the entire period of breastfeeding.

The duration of treatment depends on the nature and course of the disease and is determined by the doctor individually.

Application features

Appropriate safety precautions for use.

When taking large doses and long-term use of the drug, it is necessary to monitor kidney function and blood pressure, as well as pancreatic function. The drug should be used with caution in patients with a history of kidney disease.

In case of urolithiasis, the daily dose of ascorbic acid should not exceed 1 g.

Do not prescribe high doses of the drug to patients with increased blood clotting.

Since ascorbic acid increases iron absorption, its use in high doses can be dangerous for patients with hemochromatosis, thalassemia (Thalassemia- anemia due to increased hemolysis, which occurs due to a defect in the structure of hemoglobin), polycythemia, leukemia and sideroblastic anemia (Anemia- a group of diseases characterized by a decrease in red blood cells or hemoglobin). Patients with a high iron content in the body should use the drug in minimal doses.

The absorption of ascorbic acid can be impaired in intestinal dyskinesias, enteritis and achilia.

Use with caution in the treatment of patients with deficiency of glucose-6-phosphate dehydrogenase.

Ascorbic acid as a reducing agent can affect the results of various laboratory tests, for example, when determining the content in the blood glucose (Glucose- grape sugar, a carbohydrate from the group of monosaccharides. One of the key metabolic products that provides energy to living cells), bilirubin, activity transaminases (transaminases- enzymes of the transferase class, the reactions catalyzed by them carry out the connection between protein and carbohydrate metabolism), lactate dehydrogenase, etc.

Use during pregnancy or lactation.

The drug can be used during pregnancy or lactation in accordance with the recommendations for dosage and doctor's prescription. Recommended doses should be carefully followed and not exceeded.

Children. The drug is used in children over the age of 4 years.

The ability to influence the rate of reactions when driving vehicles or working with other mechanisms.

The drug does not affect therapeutic doses (Therapeutic dose- dose within the therapeutic latitude) on the reaction rate when driving vehicles or working with other mechanisms.

Side effect

From the digestive tract: when using more than 1 g per day - irritation of the mucous membrane of the digestive tract, heartburn, nausea, vomiting, diarrhea;

from the urinary system: damage to the glomerular apparatus of the kidneys, crystalluria (crystalluria- the presence of crystals in the urine), the formation of urate, cystine and / or oxalate stones in the kidneys and urinary tract;

allergic reactions: skin rash, angioedema (Quincke's edema- (angioneurotic edema), acute limited paroxysmal swelling of tissues that appears - the body's reaction to an allergen. Externally, Quincke's edema is manifested by sharply limited swelling of tissues (mainly lips, eyelids, cheeks), sometimes skin rashes at the site of edema, usually without itching and pain), hives (Hives- a disease characterized by the formation of limited or widespread itchy blisters on the skin and mucous membranes); sometimes - anaphylactic shock (Anaphylactic shock- a symptom complex of acutely occurring general severe manifestations of allergic reactions of an immediate type, mainly characterized by initial excitation and subsequent inhibition of the function of the central nervous system, bronchospasm, and severe arterial hypotension) in the presence of sensitization;

from the endocrine system: with prolonged use in high doses - damage to the insular apparatus of the pancreas (hyperglycemia, glucosuria);

from the nervous system: headache, feeling hot, irritability, sleep disturbance;

from the cardiovascular system:arterial hypertension (Arterial hypertension- a disease characterized by an increase in blood pressure of more than 140/90 mm Hg. Art.), dystrophy (Dystrophy- pathological changes in cells of a regressive nature with a violation or loss of their functions) myocardium;

from the blood and lymphatic system: thrombocytosis, erythrocytopenia, thrombosis, neutrophilic leukocytosis (Leukocytosis- an increase in the number of leukocytes per unit volume of blood. It can be physiological and pathological - in many infectious, inflammatory and other diseases), hyperprothrombinemia; in patients with insufficiency of glucose-6-phosphate dehydrogenase of blood cells, it can cause hemolysis of red blood cells;

from the side of metabolism: violation of the exchange of zinc, copper.

Interaction with other drugs

The drug reduces toxicity (Toxicity- the ability of some chemical compounds and substances of biological nature to have a harmful effect on the human body, animals and plants) sulfonamide preparations, reduces the effect of heparin and indirect anticoagulants, promotes the absorption of iron, increases the absorption of penicillin and tetracycline, enhances the side effect of salicylates (risk of crystalluria).

The absorption of ascorbic acid is reduced with the simultaneous use of oral contraceptives (Contraceptives- prevention of pregnancy by contraceptives), the use of fruit or vegetable juices, alkaline drinking.

The combined intake of vitamin C and deferoxamine increases the tissue toxicity of iron, especially in the heart muscle, which can lead to decompensation of the circulatory system. It can be taken 2 hours after injections (Injection- injection, subcutaneous, intramuscular, intravenous, etc. introduction into the tissues (vessels) of the body of small amounts of solutions (mainly drugs)) deferoxamine.

Long-term use of high doses by persons treated with disulfiramine inhibits the disulfiram-alcohol reaction.

Large doses of the drug reduce the effectiveness of tricyclic antidepressants (Antidepressants- means that improve mood, relieve anxiety and stress, increase mental activity. Used to treat depression, neuroleptics (Antipsychotics- medicinal substances that have a depressing effect on the functions of the central nervous system and are able to eliminate or weaken some symptoms of psychosis (delusions, hallucinations))- phenothiazine derivatives, tubular reabsorption of amphetamine, increase the excretion of mexiletine by the kidneys. Ascorbic acid increases the overall clearance (Clearance(purification, purification) - a pharmacokinetic parameter that reflects the rate of purification of blood plasma from the drug and is denoted by the symbol C1) ethanol. Quinoline drugs, calcium chloride, salicylates, corticosteroids (Corticosteroids- Hormones produced by the adrenal cortex. Regulate mineral metabolism and metabolism of carbohydrates, proteins and fats. They are used in medicine in case of their insufficiency in the body, as anti-inflammatory and anti-allergic agents) with prolonged use, they reduce the reserves of ascorbic acid in the body.

Overdose

Symptoms: epigastric pain, nausea, vomiting, flatulence (Flatulence- accumulation of gases in the digestive tract with bloating, rumbling, belching, cramping pains), diarrhea (Diarrhea- rapid release of liquid stools associated with the accelerated passage of intestinal contents due to increased peristalsis, impaired absorption of water in the large intestine and the release of a significant amount of inflammatory secretion by the intestinal wall), itching (Itching- a modified feeling of pain due to irritation of the nerve endings of pain receptors) and skin rash, increased excitability of the nervous system.

With prolonged use in high doses, inhibition of the insular apparatus of the pancreas, the development of cystitis, and the acceleration of the formation of stones (urates, oxalates) are possible.

Treatment: gastric lavage, sorbents, symptomatic treatment.