Biogenic stimulants(Greek bios life + gennaō create, produce; synonym: tissue preservation products, stimulants of biological origin) - biologically active substances formed in isolated animal and plant tissues in the process of their adaptation to adverse conditions (cooling, keeping in the dark, etc.) . When introduced into the body, they have a stimulating effect on the processes of metabolism and regeneration.
Chemical nature biogenic stimulants insufficiently studied. As a rule, they are a complex complex of substances. Qualitative and quantitative composition biogenic stimulants in tissue preparations is unstable and partly depends on the specifics of the metabolism of the tissue itself. Dicarboxylic hydroxy acids of the aliphatic series, aromatic acids of large molecular weight, amino acids, humic compounds, phospholipids, vitamins, microelements have the highest biological activity. Biological activity biogenic stimulants evaluated by their ability to activate metabolic processes in the body. Distinguish biogenic stimulants derived from plants and animal tissues, and biogenic stimulants isolated from therapeutic mud (peloids) and peat.
Pharmacodynamics biogenic stimulants determined by an increase in the intensity of metabolic, incl. bioenergy, processes, as a result of the influence on the activity of a number of enzymes. It is believed that activation occurs due to the formation of complexes of enzymes with biogenic stimulants, as well as due to a shift in the optimal zones of enzyme action. Biogenic stimulants enhance the function of the hypothalamus - pituitary - adrenal cortex, thyroid, pancreas, gonads. main pharmacological effect biogenic stimulants from peloids - anti-inflammatory action, the mechanism of which has not been elucidated.
For preparations containing biogenic stimulants of plant origin, include liquid aloe extract (for injection and for oral administration), tablets, juice and aloe liniment obtained from canned (kept at a low temperature in the dark) fresh or dried aloe leaves; Kalanchoe juice (fresh leaves and green part of the stems); biosed (water extract from canned fresh stonecrop herb). drugs biogenic stimulants of animal origin are the suspension and extract of the placenta for injection, obtained from the human placenta preserved in the cold, as well as polybiolin (a preparation from donor, retroplacental and placental human blood serum). To drugs biogenic stimulants peloids include FiBS for injection (a preparation made from liman mud distillation containing cinnamic acid and coumarins), peloid distillate (a product of estuary mud distillation), peloidin (an extract from silt therapeutic mud), gumizol (0.01% solution of humic acid fractions from the Haapsalu marine therapeutic mud in an isotonic solution of sodium chloride), peat (a product of distillation of peat from certain deposits) and vulnuzan (an ointment containing an extract from the mother liquors of the Pomorie salt lakes in Bulgaria).
Preparations biogenic stimulants apyrogenic, do not accumulate in the body, do not have anaphylactogenic, allergenic, histamine-like properties, do not cause addiction and sensitization.
The effect of most drugs biogenic stimulants nonspecific. They are prescribed to stimulate metabolic and regenerative processes, as well as to increase the body's resistance. Most widely biogenic stimulants used in ophthalmology - for blepharitis, opacification of the vitreous body, conjunctivitis, diseases of the cornea and retina, neuritis and atrophy of the optic nerve, progressive myopia, etc. (aloe extracts and tablets, biosed, fibs, peloid distillate, peat, suspension and placenta extract). In surgery drugs biogenic stimulants(Aloe liniment, biosed, peloidin, Kalanchoe juice, Vulnuzan) are used to accelerate the consolidation of bone fractures, in the treatment of purulent wounds, trophic ulcers, burns, to accelerate the resorption of scars and adhesions. In the clinic of internal diseases, extracts, juice and liniment of aloe, biosed, peloidin, suspension and extract of the placenta are used in the complex therapy of bronchial asthma, peptic ulcer of the stomach and duodenum, gastritis, gastroenteritis, colitis, rheumatoid arthritis, arthrosis, etc. In dermatology, juice and Aloe liniment is used in the treatment of inflammatory skin diseases, lupus, radiation skin lesions, chronic eczema. In neurology, FiBS, peloid distillate, peat, gumizol, placenta extract, polybiolin are used in chronic and subacute radiculitis, plexitis, and myalgia. In gynecology, peloidin, placenta extract, polybiolin are prescribed for subacute and chronic inflammatory diseases of the internal genital organs. In otorhinolaryngology drugs biogenic stimulants(extracts, tablets and liniment of aloe, biosed, kalanchoe juice, FiBS, gumizol, peloidin, peat) can be used for adhesive otitis media, cochlear neuritis, chronic inflammatory diseases of the nose, pharynx, larynx, trachea. In dentistry, biosed, gumizol and peat are prescribed for periodontal disease and chronic gingivitis. Moreover, biogenic stimulants can be used in geriatric practice, because they have a positive effect on the functional state of the aging organism.
V.'s preparations with. are used topically, orally and parenterally, as a rule, in combination with specific drugs, for example, in combination with antibiotics, synthetic chemotherapy drugs, etc. They are contraindicated in acute febrile and severe cardiovascular diseases, cerebrovascular accidents, acute disorders of the gastrointestinal intestinal tract, active form of tuberculosis, malignant neoplasms, psychosis, pregnancy.
List of main biogenic stimulants, their doses, methods of application, forms of release and storage conditions are given below.
Biosed(Biosedum) is prescribed subcutaneously or intramuscularly daily for adults, 1-2 ml(up to 3-4 ml) per day, children under 5 years old - 0.2-0.3 ml, older than 5 years - 0.5-1 ml 1 time per day, usually for 20-30 (if necessary, up to 45) days. Under the conjunctiva injected 0.3-0.5 ml within 10-25 days, in the form of eye drops - 1-2 drops 4-6 times a day. In the form of applications on the gums and electrophoresis, apply 3-5-7 min daily for 10-20 days. Release form: ampoules 1 ml.
Suspension of the placenta for injection(Suspensio Placentae pro injectionibus) appoint subcutaneously 2 ml(previously injected with 0.5% solution of novocaine) 1 time in 7-10 days, for a course of 3-4 injections. Release form: ampoules of 2 ml.
Vulnuzan(Vulnusan) is applied in a thin layer directly to the wound or to gauze applied to the affected surface. In the early days, the ointment is used daily, after the disappearance of inflammation - every other day. Release form: in tubes of 45 G.
Humisol(Humisolum) is prescribed intramuscularly for 1 ml in the first 2-3 days and in the future with good tolerance - 2 ml 1 time per day for 20-30 days. With pronounced local signs of the disease, electrophoresis with gumizol is used (10-20-30 min daily or every other day for 8-20 days). Release form: ampoules of 2 and 10 ml.
aloe liniment(Linimentum Aloes) is applied in a thin layer on the affected surface 2-3 times a day and covered with a gauze. Release form: 30-50 G in orange glass bottles.
Peloids(Peloidinum) is prescribed orally for 40-50 ml 2 times a day (morning and evening) heated for 1-2 h before meals or the same period after meals for 4-6 weeks, in the form of enemas (for colitis) 2 times a day, 100 ml within 10-15 days. Outwardly, the drug is prescribed for washing purulent wounds and for wetting dressings. Release form: 500 ml in glass bottles.
Peloid distillate for injection(Peloidodesillatum pro injectionibus) is prescribed subcutaneously, 1 ml 1 time per day for 1 month. Release form: ampoules 1 ml.
Polybiolin(Polybiolinum) before use, the contents of the vial are dissolved in 5 ml 0.25-0.5% novocaine solution; administered intramuscularly daily for 5 ml solution within 8-10 days. Release form: in vials of 0.5 G.
Aloe juice(Succus Aloes) is prescribed orally 1 teaspoon 2-3 times a day for 20-30 min before meals for 15-30 days, as well as externally in the form of lotions or irrigation. Release form: in vials of 100 ml.
Kalanchoe juice(Succus Kalanchoes) applied externally by irrigation (1-3 ml juice) wounds or ulcers with a syringe and subsequent application of a gauze bandage, richly moistened with juice, for 15-20 days, as well as in the form of applications on the mucous membranes of the oral cavity 3-4 times a day. Release form: ampoules of 10 ml and vials of 100 ml. Before drinking, the juice is kept at room temperature for at least 30 min.
Aloe tablets(Tabulettae Aloes) is prescribed orally 1 tablet 3-4 times a day for 15-20 min before meals for 1 month. Release form: coated tablets containing 0.05 G aloe leaf.
Peat(Torfotum) injected subcutaneously 1 ml daily for 30-45 days, under the conjunctiva - 0.2 each ml every other day for 1 month. Release form: ampoules 1 ml.
FiBS for injections(Fibs pro injectionibus) is applied subcutaneously, 1 ml 1 per day. The course of treatment is 30-35 injections. Release form: ampoules 1 ml.
Aloe extract liquid(Extractum Aloes fluidum) is prescribed orally 1 teaspoon 3 times a day for 30-45 days. Release form: in vials of 100 ml.
Aloe extract liquid for injection(Extractum Aloes fluidum pro injectionibus) is administered subcutaneously daily to adults, 1 ml(maximum daily dose 3-4 ml), children under 5 years old - 0.2-0.3 ml, older than 5 years - 0.5 each ml per day. The course of treatment is 30-50 injections. Release form: ampoules 1 ml.
Placenta extract for injection(Extractum Placentae pro injectionibus) administered subcutaneously 1 ml daily or every other day for 20-30 days. Release form: ampoules 1 ml.
All drugs biogenic stimulants store in a place protected from light. Some of them (aloe liniment, Kalanchoe juice) are stored at a temperature not exceeding 10 °, and polybiolin - at 10-25 °.
Bibliography: Tissue Therapy, ed. ON THE. Puchkovskaya, Kiev, 1975
Biogenic stimulants- These are substances that enhance the natural processes of healing and tissue renewal, stimulate the body. Before using them, you should consult a doctor, as there are contraindications for them.
Biogenic stimulants used by official medicine include:
- herbal preparations - extracts of aloe, stonecrop, ginseng, eleutherococcus, magnolia vine, other plants, as well as honey and propolis
- animal products - placental suspension
- firth mud preparations - FiBS, peloid distillate, peloidin and others
- preparations from peat - peat
- mumiyo
Aloe tree- perennial herbaceous fleshy, succulent plant. Its leaves contain 8 essential amino acids, vitamins A, B 2 , B 6 , B 12 , C and E, folic acid and niacin, as well as calcium, sodium, iron, potassium, chromium, magnesium, manganese, copper and zinc.
Preparations from aloe juice improve digestion, have an anti-inflammatory effect and promote wound healing, strengthen teeth and gums. Used for gastritis, gastroenterocolitis, constipation, gastric ulcer, bronchial asthma and other chronic diseases. In the form of an ointment, they are used to heal burns.
Contraindicated in severe cardiovascular diseases, hypertension, pregnancy, acute gastrointestinal
disorders, severe nephronephritis.
"Root of Life" - ginseng. In the East, especially in China, ginseng is known as an all-healing remedy. The most valuable part is the roots. The weight of individual roots of a plant that has lived for more than 100 years can reach 200 grams. Decoctions, powders, alcohol tinctures are prepared from its root. They are prescribed as a tonic for hypotension, fatigue, fatigue, neurasthenia, as well as during the recovery period after serious illness, which is usually accompanied by severe weakness, a drop in pressure and cardiac activity.
Eleutherococcus senticosus its properties are equivalent to ginseng. It inspires vivacity, returns efficiency and cheerfulness. People call it the "devil's bush". The roots and leaves of the plant are used.
Unlike ginseng, Eleutherococcus preparations are effective at any time of the year. It has tonic properties, the ability to sharpen hearing, vision, increases mental and physical performance. All these properties appear 15 days after the start of the drug.
Biosed- aqueous extract from canned fresh herb sedum of a large family of Crassulaceae. It enhances the processes of metabolism and regeneration, has a general tonic and anti-inflammatory effect. It is used as an adjuvant to stimulate metabolic and regenerative processes in ophthalmic (burns of the cornea, fresh corneal opacities), dental (periodontal disease), surgical (acceleration of the consolidation of bone fractures, treatment of trophic and varicose ulcers of the lower leg) and therapeutic (peptic ulcer of the stomach and duodenum ) practice.
Apilak- a preparation made from the royal jelly of bees. It is prescribed for children and adults to improve appetite, to strengthen immunity, to increase milk production for nursing mothers, with hypotension.
Contraindications: allergy to honey, insufficiency of the adrenal cortex.
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There is a special group of drugs that helps to start the regenerative and metabolic processes in the human body. Biogenic stimulants are preparations that are created on the basis of biologically active substances formed in the tissues of animals, plants, and also having a mineral group of origin.
These substances accumulate in individual tissues of animals, the plant environment.
These active substances help the animal to adapt to not always favorable environmental conditions, climatic conditions, life in areas with a small number of sunny days.
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Irina Martynova. Graduated from the Voronezh State Medical University. N.N. Burdenko. Clinical intern and neurologist of BUZ VO \"Moscow Polyclinic\".
Mechanism of influence
Due to the positive effect on tissues and muscles, as well as the proven effect on the central nervous system, it is permissible to prescribe such drugs, both independently and as part of complex therapy against a wide range of diseases. Tissue regeneration and relief of inflammatory processes, improvement of the body's resistance and strengthening of protective functions - this is just some list of the positive effects that biogenic compounds of substances have on the human body.
Indications for use
- Skin diseases.
- Ophthalmology.
- Dentistry.
- Neurology.
- Otorhinolaryngology.
- Gynecology.
For skin diseases: dermatitis, eczema, biostimulants of plant origin are used.
This is aloe juice, and preparations in the form of liniments (a kind of ointment, used only for external use) based on eyebright.
Speaking about aloe juice, it is worth noting its strong effect on infections caused by staphylococci, streptococci. Kalanchoe juice also has a strong effect. It stops skin inflammatory processes, even in the stage of serious exacerbation.
In ophthalmology: with conjunctivitis, blepharitis. Assign preparations based on peat, aloe, extract from the placenta.
With dental problems: gingivitis, inflammation of the palate, with periodontal disease. An aqueous extract based on stonecrop and plant substances of the Crassulaceae family is used. Often such therapy is prescribed along with antibiotics.
In neurology: for diseases associated with osteochondrosis and other diseases of the back. Showing stimulant drugs based on peat and placenta.
In diseases associated with the nose and pharynx: otitis media, bronchitis, sore throat. Assign preparations of biogenic effects based on Kalanchoe, aloe, peat.
In gynecology: this group of stimulants is used for inflammation of the genital organs.
Stimulants containing an extract from the placental part of the blood (serum) are prescribed as part of complex therapy.
Contraindications
It should be remembered that biogenic stimulants are drugs that need careful and careful use. A significant number of contraindications lies in their activating and stimulating effect.
Since these stimulant compounds are of plant or animal origin, it is necessary to observe the allergic reactions of the body, which may occur already at the initial stage of taking the medicine.
An allergic reaction can be in the form of hives, itching, burning.
Often, biogenic drugs should not be prescribed during pregnancy or during breastfeeding.
Stimulants based on placental suspension should not be used for tuberculosis, for diseases associated with the lymph nodes, during pregnancy and lactation, as well as for any cardiovascular diseases, kidney and liver damage.
As can be seen from the examples given, different contraindications are dictated by the different origin of this group of drugs. It should not be underestimated that biogenic amines can adversely affect tumor growth. Therefore, these drugs cannot be used uncontrollably for neoplasms, even if the tumor is benign.
A lot of controversy is going on around the group of biogenic preparations based on aloe. Contraindications depend on the method of application. They can not be used inside for any type of bleeding, hemorrhoids in the acute stage, oncology, cystitis, kidney disease. Any diseases of the gastrointestinal tract in the acute stage are a serious contraindication for the appointment of this group of drugs.
Do not take the juice of this drug to children and the elderly.
Features of prescribing drugs
The biogenic stimulant has a tonic effect that increases endurance and muscle tone, and also helps to accelerate metabolic processes in tissues and their regeneration. Therefore, in a number of diseases they are prescribed as a course, as part of combination therapy. Consider examples of stimulating dosage forms of animal and vegetable origin. For example, Actovegin stimulant. Stimulant based on animal raw materials: the main component is the blood of calves.
Despite the fact that in the instructions for use there is a note about caution when administered during pregnancy.
But it is prescribed in some cases to expectant mothers. If the fetus has hypoxia (fetoplacental insufficiency has formed), then this drug is necessary. The doctor assesses the risk of contraindications and the condition of the pregnant woman. This medicine starts the processes of activating the growth and nutrition of capillaries in the placenta, improves nutrition at the cellular level of the uterus. When adequate nutrition is supplied to the small capillaries of the placenta, the condition of the fetus itself improves. In obstetrics, this drug is often prescribed together with group B vitamin preparations (for preeclampsia, along with sedative, diuretic drugs.) Actovegin not only improves nutrition through the placenta, but also significantly helps the development of the fetus.
Also, stimulants can be prescribed as part of combination therapy and when applied topically.
For example, with some types of burns and skin lesions, aloe vera is applied to the affected area. And at the same time, therapy can be carried out at the same time to prevent the development of sepsis.
This group of drugs can not be used uncontrollably. Moreover, it is important that the doctor prescribing the treatment correlates the risk of side effects and the patient's health status. The therapeutic effect of a group of biogenic drugs is high, but the application requires attention and a systematic approach. During therapy, the doctor may reduce or increase the course of taking these medicinal compounds of biological origin. Each dosage form of stimulants has detailed instructions describing dosages and areas of application. In case of any complications, you should immediately consult a doctor and replace the medicine.
Preparations based on natural products of animal or plant origin also require monitoring in the event of allergic reactions.
List of drugs
Most often, doctors prescribe the following groups of stimulating dosage forms:
Plant origin:
- Befungin
- Biosed
- Kalanchoe (juice)
Based on animal tissues:
- Apilak
- Glunate
- Lidaza
- Plazmol
- vitreous body
Based on peat distillation products, therapeutic mud:
- Humisol
- Peloidin
- Peat
Aloe
In the form of a liquid extract, it is prescribed for injection in bronchial asthma, in ophthalmology. Tablets with aloe - prescribed for eye diseases (complex therapy in the treatment of myopia). Liniments, ointments - treatment of dermatological skin diseases, burns. Syrup - prescribed for iron deficiency anemia.
Side effects: allergic reactions with external treatment.
When taken orally, an increase in pressure, increased heart rate, tachycardia is possible.
Biosed
Consists of stonecrop herb in canned form. It has a strong regenerating effect. The drug enhances metabolic processes in tissues, while it is a tonic and anti-inflammatory drug. Scope: corneal burns, inflammatory processes in the eye area. In dentistry: prescribed for periodontal disease. With trophic inflammations (ulcers), fractures, wounds. The form of administration can be parenteral or electrophoresis.
Side effects: Redness and itching often occur at the injection site. This refers to an allergic reaction that does not require discontinuation of the drug.
Kalanchoe juice
It treats diseases of the throat - tonsillitis, stomatitis. It is an excellent hemostatic medicine. Juice treatment is also indicated for eczema, psoriasis.
In case of inflammation of the gums, pieces of cotton wool are moistened with aloe juice and short-term compresses are made. Juice effectively removes various types of inflammatory processes and disinfects.
Actovegin
The release form is tablets, ampoules with a solution for injection, cream and gel. In the composition, as the main substance, deproteinized hemoderivative of calf blood.
Tablets: prescribed for violations of the blood supply to the brain, the initial stage of dementia, disorders caused by trophic ulcers. In the complex treatment of pregnant women - with insufficient fetal development, signs of fetal hypoxia. Price: tablets, 50 pcs. - 1554 rubles.
Solution for injection: prescribed for strokes, polyneuropathy in diabetes - damage to the nervous system during a long illness. Such a complication occurs after 20-25 years of illness. Together with glucose, sodium chloride. There are no data on interactions with other drugs. Price: 25 ampoules, 1499 rubles.
Gel and cream: Actovegin in the form of a gel is prescribed for wounds, burns, abrasions, bedsores. It has a strong regenerating property. Promotes skin regeneration and healing.
Cream: With ulcers and varicose veins, with a decrease in the effects of radiation effects on the skin.
When used orally, stagnation associated with the accumulation of fluid in the body is possible. As a result of a large amount of animal protein, the human body begins to retain water, swelling appears. Some patients also experience heart failure. Reception of Actovegin in this case should be stopped immediately. Price: for cream, gel from 530 rubles.
Apilak
Created on the basis of royal jelly. It has a powerful stimulating, regenerative, anti-spasmodic effect. Assign for bleeding, after childbirth and during menopause. The medicine has proven itself well as a therapy after a heart attack. It is one of the few biogenic medicines that can be given to children suffering from low weight and poor appetite.
Price: apilac tablets, 50 pcs -367 rubles. Ointment apilak, 50 grams -230 rubles.
Glunate
Consists of plasma and serum of human blood. Effective for trophic ulcers, long-term non-healing skin lesions. With inflammation of the lungs, glunate is prescribed as a possible activator of immunity. Stimulates the protective functions of the body.
Release form: ampoules for injections. Glunate should not be used for tuberculosis, thrombophlebitis and tumors (benign or malignant). Sale of medicines only by prescription.
Lidaza
A stimulant derived from the seminal glands of cattle. It is prescribed for the treatment of hematomas, arthritis, arthrosis, myocardial infarction, tuberculosis, burns, scars. Contraindications: oncology, infections in the acute stage, a form of tuberculosis with impaired respiratory function.
Price: 10 ampoules-348 rubles.
Plazmol
A stimulant created on the basis of plasma, donor blood in the form of an extract, native and erythrocyte mass. Strong effect in the treatment of bronchial asthma. Relieves pain from sciatica. Polyarthritis, neuritis. Plasmol should not be used in case of tuberculosis, pregnancy and lactation, nephritis, autoimmune diseases.
Excluded medicine for children.
vitreous body
Obtained from the vitreous body of the eye of cattle. A stimulant that starts metabolic processes in bone and cartilage tissues. It is prescribed by a doctor in case of treatment of keloid, burn, postoperative wounds. The vitreous body is prescribed for fractures, when it is necessary to form a callus, as soon as possible. With the resorption of the adhesive process in gynecology. Relieves neuralgic pain, exacerbation of sciatica.
Contraindicated in nephritis, cirrhosis of the liver, heart failure.
Biogenic medicine for the benefit of nature's growth
Separately, it should be noted the biogenic stimulator Biostim. It is treated with attention when growing shrubs and flowers. Growth stimulator based on phytohormones. Helps with the growth of seedlings and seedlings.
Promotes greater endurance of the root system of large shrubs, tree seedlings.
A special group of preparations based on peat and therapeutic mud
Humisol
Extract from Haapsalu therapeutic mud. Treats arthrosis, arthritis, radiculitis.
Applicable to children. Contraindications: heart disease, tuberculosis, cancer, kidney disease, liver disease, mental illness.
Peloidin
In the composition of silt therapeutic mud. Helps with diseases of the gastrointestinal tract, gastritis, colitis, ulcers.
Mud method of treatment is effective for most diseases of the musculoskeletal system.
Peat
A colorless liquid derived from peat.
Helps with myopia, clouding of the cornea of \u200b\u200bthe eyes. It is also used in gynecology for the treatment of inflammatory diseases, even in the chronic stage.
FiBS
Aqueous solution of biogenic stimulants obtained from firth mud. It is indicated for diseases of the eyelids, blepharitis, conjunctivitis. Effective in the treatment of muscle pain, arthritis.
Contraindicated: last trimester of pregnancy, kidney disease, high blood pressure (hypertension), gastrointestinal disorders.
It is better not to use biogenic stimulants with alcohol.
There are no studied data on the interaction with alcohol for all drugs in this group, but if we consider contraindications, then many drugs cannot be used for liver problems.
Alcohol can increase the load on the liver, so it is better to refrain from taking this group of drugs and alcoholic beverages.
Biogenic stimulants are groups of substances formed in living isolated tissues placed in unfavorable conditions (darkness, cold, etc.). As a result of tissue adaptation, biologically active substances are produced in them, which, when introduced into the body, have a stimulating effect, accelerate regeneration processes, and activate the endocrine system. Medicines of biogenic stimulants are widely used in ophthalmology, dentistry, surgery, therapy, dermatology, etc.
Herbal medicines
Aloe extract liquid for injection- aqueous extract from stimulated leaves of aloe arborescens. Used for a number of eye diseases (progressive myopia, blepharitis, conjunctivitis, keratitis, etc.), gastric ulcer, inflammatory gynecological diseases, bronchial asthma, etc. Contraindicated in severe cardiovascular diseases, arterial hypertension, acute gastrointestinal disorders, pregnancy.
Biosed- water extract from preserved fresh herb stonecrop large. It enhances the processes of metabolism and regeneration, has a general tonic and anti-inflammatory effect. It is used for inflammation and burns of the cornea, periodontal disease, trophic wounds, ulcers, fractures. It is administered parenterally, locally in the form of applications, using electrophoresis. When using the drug, hyperemia and a rash at the injection site may be noted.
Medicinal products of animal origin
vitreous body obtained from the vitreous body of the eye of cattle. It is used for resorption and softening of scars, inflammation of the joints, with neuralgia, radiculitis, ulcers and burns of the oral membrane.
Plazmol obtained from human blood. It is used as an anesthetic for neuralgia, radiculitis, arthritis, as well as gastric ulcer, bronchial asthma.
Solcoseryl (actovegin)– calf blood extract. It is used to improve metabolic processes and accelerate tissue regeneration in trophic ulcers, bedsores, burns, gastritis, skin grafting, vascular diseases, injuries, gastric and duodenal ulcers, and inflammatory diseases of the oral mucosa. Applied parenterally, orally, topically. Allergic reactions are possible.
Apilak- dry matter of royal jelly. Assign children with malnutrition and anorexia, adults - with hypotension, malnutrition, neuroses, lactation disorders, seborrhea of the skin of the face. Apply sublingually and topically.
Cerebrolysin(cerebrolysate) - a complex of peptides derived from the brain of a pig. It is used for damage to blood vessels and brain tissues.
Lidaza- A drug obtained from the testes of cattle, containing the enzyme hyaluronidase, which causes the breakdown of hyaluronic acid to glucosamine, increases tissue permeability and facilitates the movement of fluids in interstitial spaces. Used for resorption of scars after burns and operations, for the treatment of burns, ulcers, pulmonary tuberculosis, eye diseases. Side undesirable effect - allergic reactions.
Chondroitin sulfate(chondroitinsulfuric acid) is a high molecular weight mucopolysaccharide, which, along with hyaluronic acid, is an integral part of cartilage tissue. Chondroitin sulfate stimulates regeneration processes and slows down the degeneration of cartilage tissue, normalizes the production of joint fluid. Structum, Rumalon, Chondroxide, Teraflex, Mukosat obtained from the cartilage of cattle. They are used for inflammatory diseases of the joints (arthrosis, arthritis, etc.), degenerative diseases of the spine (osteoarthritis, osteochondrosis).
Synthetic drugs
Carnitine chloride(levocarnitine) has antihypoxic, anabolic, stimulates tissue regeneration. Carnitine is involved in biochemical processes in muscle tissue. It has an anabolic effect, causes an improvement in appetite, acceleration of growth and an increase in body weight. They will be used for angina pectoris, myocardial infarction, children with anorexia, malnutrition, growth retardation. Well tolerated.
Mildronate is structurally similar to carnitine. It has a cardioprotective, antihypoxic, antianginal effect, stimulates physical performance, activates the immune system. It is used for cardiovascular diseases: angina pectoris, myocardial infarction, chronic heart failure.
| Drug name, synonyms, storage conditions | Release forms | Application methods |
| Extractum Aloes fluidum pro injectionibus | Amp. 1ml | Under the skin, 1 ml |
| Linimentum Aloes | Flac. 50.0 | On the affected surface of the skin |
| biosedum | Amp. 1ml | 1 ml per muscle |
| Plasmolum | Amp. 1ml | Under the skin, 1 ml |
| corpus vitreum | Amp. 2ml | Under the skin, 2 ml |
| Solcoserylum | Dragee (table) 0.04; 0.1; 0.2 Amp. 2ml; 5ml; 10ml Ointment, cream, gel 5.0; 20.0; 30.0 | 1 tablet (table) 2-3 times a day In a vein, 10 ml. In the muscle, 5 ml On the affected surface 1-3 times a day |
| Apilacum | Tab. 0.01 Candles 0.005; 0.01 Ointment 3% - 50.0 | 1 tab. under the tongue 3 times a day 1 suppository into the rectum 2-3 times a day On the affected areas of the skin |
| Lidazum | Flac. 0.1 dry in-va (64 c.u.) | Under the skin into the tissue (with 1 ml of 0.5% solution of novocaine), inhalation |
| Mildronatum (B) | Caps. 0.25 Amp. 10% solution - 5ml | 1 caps. 2-4 times a day In a vein, 5 ml |
Control questions
pharmachologic effect
Biogenic stimulants enhance metabolic processes and regeneration, have a general tonic and anti-inflammatory effect. Promote the resorption of inflammatory infiltrates, reduce pain; increase the detoxifying function of the liver and have immunostimulating properties (splenin); stabilize cell membranes, inhibit lipid peroxidation, stimulate hepomoesis (ceruloplasmin, erythrophosphatide, erygem); improve metabolic processes in violation of cerebral and peripheral circulation (actovegin); regulate the functions of the endocrine system (epithalamin); stimulate leukopoiesis during radiation therapy and chemotherapy of tumors (zymosan); have a positive effect on prostatitis, benign hyperplasia and the initial phase of prostate adenoma (cernilton, trianol, raveron); used to treat patients with multiple sclerosis (propermil).
Classification of biogenic stimulants
The entire large group of biogenic stimulants can be classified according to their origin:
herbal products;
means of animal and human origin;
mineral products.
Biogenic stimulants of plant origin:
Preparations containing biogenic stimulants of plant origin include: liquid aloe extract (for injection and oral administration), tablets, juice and aloe liniment obtained from canned (kept at a low temperature in the dark) fresh or dried aloe leaves. Aloe leaf extract (Extractum Aloes) is obtained from biostimulated (canned) leaves of treelike aloe - Aloe arborescens Milli. For biostimulation, aloe leaves are kept in the dark at 4-8°C for 10-12 days. Then they are washed, dried, cloves, yellowed ends are removed and crushed on rollers. The resulting slurry is poured with 3 times the amount of distilled water and infused at room temperature. After 2 hours, the contents of the tincture are heated and boiled for 2-3 minutes (to coagulate proteins), after which it is filtered. The filtrate is allowed to cool, its volume is measured and the oxidizability determined by titration with 0.01 N. potassium permanganate solution in the presence of sulfuric acid. In accordance with the analysis data, the filtrate is diluted with such an amount of water that its oxidizability is equal to 1500 mg of oxygen per 1 liter of filtrate.
Sodium chloride (7 g per 1 L) is added to the filtrate, boiled again for 2 minutes and filtered. A transparent extract is poured into vials (for internal use) or ampoules, which are sterilized in an autoclave at 120 ° C for an hour. In the manufacture of aloe extract, the use of iron equipment is unacceptable. The drug is a clear liquid from light yellow to yellowish red; pH 5.0-5.6. Store in a dark cool place. Shelf life 6 months. It is used for a number of eye diseases, conjunctivitis, blepharitis, trachoma, clouding of the vitreous body, etc., as well as for peptic ulcer of the stomach and duodenum, bronchial asthma, etc.
Kalanchoe juice (Succus Kalanchoes). Juice from fresh leaves and the green part of the stems of the Kalanchoe pinnate plant, fam. crassian. Yellow liquid with an orange tint, aromatic odor, transparent or slightly opalescent, with a fine suspension, easily broken when shaken. Kalanchoe juice has a local anti-inflammatory effect, helps cleanse wounds from necrotic tissues, and stimulates their healing. Applied externally in the treatment of trophic ulcers, non-healing wounds, burns, bedsores, nipple cracks in nursing mothers, aphthous stomatitis, gingivitis, etc. The wound or ulcer is irrigated with juice (1-3 ml) using a syringe and a gauze bandage is applied (4- 5 layers), richly moistened with juice. The bandage is changed first daily, then every other day. Once a day, additionally moisten the lower layers of the bandage with juice (removing the upper layers). The average duration of the course of treatment is 15-20 days. Kalanchoe juice is applied to the mucous membranes of the oral cavity in the form of an application 3-4 times a day. Apply several times a day to cracked nipples. The drug is usually well tolerated. In the event of a burning sensation in the wound, Kalanchoe juice can be diluted with an equal amount of 1-2% novocaine solution. Release form: in ampoules of 10 ml or in vials of 100 ml in a package of 10 ampoules or vials. Storage: at a temperature not higher than + 10 "C. Before use, the juice is kept at room temperature for at least 30 minutes. In dental practice, the juice is heated in a water bath to a temperature of + 37 "C before use.
Biosedum (Biosedum) water extract from biostimulated fresh herb stonecrop (Sedum maximum L.Suter) which is crushed, poured with 10 times the amount of water and heated at a temperature of 95-98 ° C for 10 minutes. The operation is repeated twice. The extract and juice are combined, squeezed, settled, filtered. Biosed is a clear liquid, light yellow in color with a slight peculiar odor. It is poured into ampoules of 1 ml, sterilized at a temperature of 120 ° C for 30 minutes and stored in a place protected from light.
