Sinusitis is an unpleasant disease, so there is a great desire to get rid of the pathology in a short time. The potent drug Dioxidin will help eliminate manifestations and prevent the development of complications.

What is sinusitis

Sinusitis is a type of sinusitis during which inflammation affects the maxillary sinus. The incidence increases in cold weather, as the body is more vulnerable to infections.

As pathology develops, mucus accumulates in the nasal sinuses, its viscosity increases, and the tissues become inflamed and swollen. A person loses his sense of smell, suffers from heaviness in the head, pain in the temples and bridge of the nose, and body temperature rises.

Sinusitis affects adults, but also occurs in children over 4–5 years of age, which is due to the immaturity of the sinuses in children.

Description of the drug: composition and release form

The drug Dioxidin is available in several forms:

• 1% solution for local and intracavitary use;
• 0.5% solution for intracavitary, intravenous and local use;
• 5% ointment.

The main active ingredient is hydroxymethylquinoxaline dioxide. The component is partially absorbed when used topically, without causing irritation to the mucous membranes.

Hydroxymethylquinoxaline dioxide acts on the walls of pathogenic bacteria, suppressing their vital activity. As a result, the death of microorganisms occurs.

Additional components are:

1. In solutions - water for injection.
2. In ointment:
   • paraxybenzoic acid propyl ester;
   • polyethylene oxide 1600;
   • nipagin;
   • polyethylene oxide 400.

Action and efficiency

Thanks to the active component, the drug Dioxidin has the following effects:

• restorative;
• antibacterial.

The product copes well with the following bacteria:

• proteas;
• staphylococci;
• Pseudomonas aeruginosa;
• streptococci.

The drug has a significant advantage over other drugs - the drug remains effective even against microorganisms that are resistant to other antibiotics.

Contraindications for use

Contraindications to the use of Dioxidin are:

• adrenal insufficiency;
• kidney and liver diseases;
• hypersensitivity to the components of the product;
• pregnancy - the active substance is able to penetrate the placenta, leading to changes in fetal cells;
• breastfeeding period - the active component can enter the child’s body through milk;
• age up to 12 years.

Side effects

The drug is potent, so treatment may adversely affect the patient's immune system. In addition, the patient may experience the following symptoms:

• headache;
• increased body temperature;
• diarrhea;
• chills;
• allergic reaction;
• nausea.

The appearance of signs indicates the need to stop treatment - you need to visit a doctor and get a diagnosis.

How to use the product

Dioxidin is used as a solution for instillation or rinsing of the nose, but sometimes a nebulizer is used for inhalation.

Nasal rinsing

Before rinsing, breathing through the nose should not be difficult, so it is recommended to remove mucus from the nasal passage. After preparation, treatment begins:

1. Dilute the drug (0.5%) with water for injection in equal proportions.
2. Place the medication in each nostril in the dosage prescribed by the doctor.

In addition to water for injection, various combinations of agents are used. In addition to Dioxidin, the solution may include:

• Naphthyzine and Hydrocortisone;
• Naphthyzine and Dexamethasone;
• Sulfacyl sodium, Dexamethasone and Naphthyzin.

All components are mixed in equal proportions. The frequency of procedures is from 3 to 5 per day, and the maximum duration of treatment is no more than 1 week.

Combinations of products with Dioxidin - gallery

Dexamethasone is an eye drop, but due to its anti-inflammatory effect it can be effectively used with Dioxidin for the treatment of sinusitis Hydrocortisone has an anti-edematous effect Naphthyzin has a vasoconstrictor effect

Inhalation

For inhalation, the product is diluted with physiological solution in the following way:

• 0.5% - ratio 1 to 2;
• 1% - ratio 1 to 4.

Inhalation using a nebulizer is carried out 2 times a day.

How to replace medicine

If it is impossible to use the drug, the doctor may recommend means that can replace it.

Dioxidin analogs for the treatment of sinusitis - table

It would seem that this is not such a serious symptom that is worth focusing your attention on. Not everyone tries to treat it. It must be said that such an attitude can lead to a much more unpleasant problem in the form of inflammation of the maxillary sinuses and the addition of a bacterial infection to the process. To get rid of it, it is recommended to use Dioxidin, a broad-spectrum antibacterial agent.

Description of the drug Dioxidin: action and effectiveness

Sinusitis is understood as a violation of the discharge of mucus from the nasal sinuses, an increase in its viscosity, due to which it begins to accumulate, the mucous membrane of the sinuses becomes inflamed, and a bacterial infection joins the process. All this is accompanied by severe headaches. At first they have a clear localization, then the whole head begins to hurt. Green contents come out of the nose, body temperature rises to 38 degrees. It would seem that it is simply impossible to overcome such an unpleasant disease without resorting to a puncture (puncture). However, there are ways to help cope with this problem.

Sinusitis is an inflammation of the paranasal sinuses as a result of stagnation of mucus in them and the addition of a bacterial infection to the process

The drug Dioxidin has been successfully used by otorhinolaryngologists for the treatment of sinusitis for many years. It helps relieve swelling from the inflamed mucosa, destroy the pathological microflora that has “started up” in the sinuses, and normal discharge of contents from the sinuses.

Already after the first use, relief is noted: the ability to breathe normally is restored, headaches become less intense. By the end of treatment, all unpleasant symptoms disappear completely.

Dioxidin is classified as an antibacterial drug with a wide range of effects. It has an effective effect on infections caused by pathogens such as:

• dysentery bacillus;
• Pseudomonas aeruginosa;
• Klebsiella;
• Proteus vulgaris;
• streptococci;
• staphylococci;
• salmonella;
• pathogenic anaerobes (including those causing gas gangrene);
• microbes resistant to other drugs.

Release forms

The drug is available in several forms, in which the same active substance, hydroxymethylquinoxaline dioxide, is present in different concentrations. So, in pharmacies you can see the medicine in three forms:

• solution for intracavitary and external use with a concentration of 0.5 and 1%;
• solution for intravenous administration with a concentration of 0.5%;
• ointment for external use with a concentration of 5%.

The auxiliary components are not the same. In solutions this is special purified water for injection. The ointment contains polyethylene oxide 1500 and 400, nipazole (propyl parahydroxybenzoate) and nipagin.

For the treatment of sinusitis, Dioxidin is used in the form of a solution both for intracavitary and external use, and for intravenous administration.

Forms of release of Dioxidin - photo gallery

Dioxidin in the form of a solution for intravenous administration Dioxidine in ointment form is used externally
Dioxidin in the form of a solution for external and intracavitary use

Possible side effects, contraindications

Unlike many antibiotics, Dioxidin has a minimum of contraindications and adverse reactions. It can be used even by infants (over six months), but only in diluted form (for a minimum concentration of the drug).

The use of the drug is contraindicated:

• during pregnancy;
• during the lactation period;
• in children under five years of age (in its pure form);
• with adrenal insufficiency;
• in case of individual intolerance to the active component of the drug.

During pregnancy, the use of the drug is contraindicated, as it has been proven that it leads to mutations in the fetus. It is also not advisable to use Dioxidin during lactation, as it is excreted in milk. If therapy with this drug is nevertheless necessary, the child must be fed with an artificial formula during treatment and for two to three days after its completion.

The drug should be used with caution in persons with renal failure.

During the use of Dioxidin, some unpleasant side effects may occur in the form of:

• headaches;
• allergic reactions (from itching sensations to the development of angioedema);
• increased body temperature;
• chills;
• seizures;
• nausea;
• vomiting;
• diarrhea;
• feeling of dryness in the nose.

As medical practice shows, the likelihood of such reactions occurring is minimized.

Instructions for use of the drug for adults and children

Treatment of children and women who are breastfeeding should be carried out under strict medical supervision with strict adherence to all recommendations.

For the treatment of sinusitis, a solution is used:

• with a concentration of 0.5%:
  • for children and nursing mothers, use it diluted in a ratio of one to two (or one to three) with isotonic sodium chloride solution (or special water for injection);
  • everyone else is most often prescribed in its pure form;
• with a concentration of 1% in pure or diluted form for persons who have no contraindications.

Before using Dioxidin, the patency of the nasal passages should be restored. To do this, you need to clear the contents from your nose and drip vasoconstrictor drops.

Relief of sinusitis symptoms occurs after the second use of the product. Despite this, treatment should not be stopped. The drug will finally help only after a certain course (on average 5–7 days, but in advanced cases, therapy can last up to three to four weeks).

How Dioxidin is used: rinsing, inhalation, nasal instillation

1. Rinsing the nose with Dioxidin is no different from rinsing with other solutions. You can learn more about the detailed procedure from an otolaryngologist. An undiluted solution is used for these purposes in the amount recommended by the doctor. This use of the drug is carried out once a day.
2. Inhalations of Dioxidin are no less effective in the treatment of sinusitis. It is most convenient to carry them out using a nebulizer; you can also use a regular inhaler. The drug is diluted with isotonic sodium chloride solution in a ratio of one to four. It can also be used once a day.
3. Dioxidin for nasal instillation. As a rule, for greater effect it is mixed with other drugs, for example, Dexamethasone, Hydrocortisone, Naphthyzine, Xylometazoline and others. The drug will be no less effective when diluted with saline or special water for injection. These drops are used two to five times a day.

The duration of therapy and dosage of the drug is determined by the attending physician individually for each patient.

How can you replace Dioxidin?

Dioxidin has analogues, both structural and with another active substance.

Dioxidine analogues - table

When a runny nose occurs, many of us approach this problem differently. Some snot cannot be treated and they think it will go away on its own, while others, on the contrary, drip everything into the nose.

Such approaches to the treatment of a runny nose are fraught with allergic reactions, the occurrence of protracted inflammatory processes, and drying of the nasal mucosa. In treatment, as in life, there should be moderation in everything. Therefore, it is better to determine the right medication in the otolaryngologist’s office. There is a drug on the pharmaceutical market called dioxidin, which doctors use in the treatment of complicated runny nose.

Important! Every patient should know that dioxidin is not used for the following types of runny nose:

• allergic;
• vasomotor;
• medicinal;
• viral;
• atrophic and hypertrophic;
• traumatic.

• purulent wounds of various locations;
• burns with an infected wound surface;
• phlegmon;
• pleurisy of purulent origin;
• trophic ulcers;
• peritonitis;
• other purulent processes.

Dioxidin is an antibacterial agent that destroys a wide range of pathogenic microflora. It also affects pyogenic microbes. Often, dioxidin is highly effective in cases where other antibacterial agents have failed.

Therefore, the drug is prescribed only for pronounced purulent processes and severe forms of infection. Dioxidin successfully suppresses staphylococcus, anaerobes, Klebsiella, salmonella, streptococcal pathogens, Pseudomonas aeruginosa and other infections.

Despite the absence of indications for the treatment of runny nose in the instructions for the drug, ENT departments successfully use dioxidin in their work. Now, let's take a closer look at how dioxidin is used in practice to treat a runny nose.

As a result of the accumulated experience in using dioxidine, we present to your attention a detailed guide to using dioxidine for a prolonged runny nose.

What form of the drug can be used for nasal instillation?

At the pharmacy you can buy ampoules with 0.5 or 1% dioxidine solution. One ampoule contains 10 ml of medicinal solution. For each instillation, the solution must be fresh; it is not recommended to store open ampoules, but in practice, an ampoule is more often used during the day (enough for three instillations: morning, afternoon and evening). The ampoule must be stored in the refrigerator, after covering the open neck with a cotton swab.

Important! Ampoules with a 0.5% solution do not need to be diluted before intranasal (through the nose) administration, but a 1% solution should be diluted in a 1:1 ratio with saline or distilled water.

How to use dioxidin correctly?

Usually the drug is used externally, intravenously or injected into the lesion cavity. To treat a persistent runny nose, dioxidine is instilled into the nasal passages. When treating sinusitis, the drug is administered intracavitarily.

The ampoule with the solution is opened and the required dose of the drug is drawn into the pipette. The average dose for adults is 2-3 drops in each nostril three times a day; for children, 1-2 drops 2-3 times a day are enough. According to indications, the doctor prescribes the required amount of the drug in each individual case of treatment of prolonged rhinitis or sinusitis.

For the best effect of the drug, pre-wash the nasal passages with saline solutions: Aquamaris, Quix, Marimer and others. The saline solution is easy to prepare at home: for a glass of boiled water at room temperature, you need to take 3-5 grams of table or sea salt. Stir the contents thoroughly so that the salt crystals all dissolve. Then inject about 1 ml of solution into each nostril.

After rinsing, blow your nose, and after 3-5 minutes, drip the dioxidine solution. The course of treatment with dioxidine depends on the severity of the infectious process, but does not exceed a week.

Dioxidin shows high effectiveness in purulent processes, and the symptoms of the disease usually disappear within 3-4 days after the start of the medication. The drug is so powerful that all pathogenic flora die with lightning speed.

Is there any harm from using dioxidine?

Dioxidin exhibits toxic activity and cannot be used for a long time. It has contraindications in the following cases:

• pregnancy (due to teratogenic effects on the fetus),
• breastfeeding;
• individual intolerance;
• severe diseases of the kidneys and adrenal glands.

When using dioxidine, side effects may also appear, such as:

• hyperthermia (increased body temperature);
• allergy;
• age spots;
• chills;
• stool disorder;
• headache;
• convulsive muscle twitching;
• dermatitis (in cases of using dioxidine externally).

Such side effects appear with intracavitary and intravenous administration of the drug. To relieve them, antihistamines (suprastin, erius, claritin, others) and calcium supplements are used. In case of severe intolerance, the drug is discontinued.

When administered intranasally, side effects, as a rule, do not develop. Only in the case of treatment of sinusitis, when intracavitary lavage of the sinuses is performed, unpleasant side symptoms may appear.

Is it possible to use dioxidin for a runny nose in a child?

Many parents are wary of prescribing dioxidine, and this is justified. The instructions clearly warn that the drug is intended for adults only. But, despite such instructions, otolaryngologists still use dioxidin in children in the treatment of various types of runny nose.

Due to the fact that there is completely no information in the instructions for the use of dioxidin in childhood, as well as its use for a runny nose, parents should make a decision together with their doctor, weighing the pros and cons: to use the drug for treatment or not.

Practicing doctors speak positively about dioxidine and believe that its use is often justified. They did not notice any special complications or severe consequences during the treatment of the runny nose with dioxidine.

Dioxidin is often used for inhalation for the common cold, including for children. You should start using this treatment method only with your doctor's permission.

Can dioxidin be used in pregnant women?

Dioxidin has a teratogenic effect, and this can cause irreparable malformations of the fetus. Therefore, it is not recommended to use the drug during this period of a woman’s life, especially in the earliest stages of pregnancy (before the 12th week).

Drawing conclusions

After reading the article, many wondered whether it is worth treating a runny nose with dioxidine if there are no clear instructions for use in this pathology.

You will have to decide for yourself. Although few patients study the instructions and more often trust the doctor’s experience.

The positive thing is that the drug has long been tested in practice and shows excellent results in the treatment of rhinitis. A negative feature is that there are no scientific conclusions on the use of dioxidin in ENT practice.

The ideal is not to let the disease progress and treat a runny nose without leading it to protracted forms and the development of sinusitis. Try to use traditional medicine and traditional drugs that have been effective in eliminating inflammation of the nasal mucosa for many years. And only in case of urgent need to resort to “heavy artillery” - dioxidin!

The truly domestic antiseptic Dioxidin has a lot of positive qualities. Its wide spectrum of action and availability have made it one of the most popular antimicrobial agents in Russia and the CIS countries. And the possibility of intracavitary use allows the drug to be used for acute and chronic sinusitis.

Dioxidin: the beginning of a long journey

Dioxidin is an original Russian drug, developed about 30 years ago by Soviet scientists at the All-Union Chemical and Pharmaceutical Research Institute. Then chemists conducted a fairly large study, during which they studied the antimicrobial effect of a group of substances - quinoxaline derivatives. During the experiment, it turned out that among several compounds, one stood out as having the most pronounced antimicrobial effect. This was Dioxidin.

Let us add that at the same time another drug of this group was developed - Quinoxidine. It is very similar in structure to the famous antiseptic and has a similar spectrum of action and activity. Quinoxidine is used orally, but it has not achieved such popularity as its relative.

Composition and release form

The simple and catchy trade name hides a complex organic substance called hydroxymethylquinoxaline dioxide. It is available in two different dosages, and when purchasing Dioxidin for nasal rinsing for sinusitis, this fact should be taken into account.

So, Russian pharmaceutical companies produce:

• a solution in a concentration of 1%, which is intended for intracavitary and external use and is packaged in glass ampoules containing 10 ml of the drug;
• solution at a concentration of 0.5%. This form of release is used externally, intravenously and intracavitarily and is available in ampoules of 10 and 20 ml.

For rinsing the nasal cavity, the drug is most often used in a concentration of 0.1%.

How does Dioxidin work?

Dioxidin is a synthetic substance that has a pronounced antibacterial effect against a wide range of microorganisms. The antiseptic has a bactericidal effect: it inhibits DNA synthesis inside the microbial cell, and also provokes structural “breakdowns” of the cell membrane. As a result, the microbe becomes unviable and dies.

Susceptible bacteria include gram-positive and gram-negative microorganisms, including:

• Proteus;
• pseudomonas;
• coli;
• Klebsiella;
• streptococci;
• clostridia.

A positive feature of the drug is that it is effective against strains of bacteria that are resistant to, including those that produce beta-lactamase.

Considering the spectrum of action of Dioxidin, it is used for the treatment of acute and chronic sinusitis associated with staphylococcal, streptococcal infections, as well as infection with gram-negative flora.

The antiseptic penetrates the tissue very quickly - within 1–2 hours after application, a concentration in the blood close to the maximum is reached. In addition, the effectiveness of the medicine lasts quite a long time - for 4–6 hours. Note that when used topically (including when washing the nasal cavity and maxillary sinuses), the Dioxidin solution is slightly absorbed into the blood, but it is not irritating and practically has a systemic effect. Another advantage of the drug is the absence of an accumulated effect.

Dioxidin for sinusitis: instructions for use

The drug is used for a wide variety of inflammatory diseases, including rhinitis and sinusitis. To wash the maxillary sinuses, use a 1% solution of Dioxidin in a volume of 10–50 ml. It should be taken into account that the maximum dose of the drug that can be used per day is no more than 70 ml of a standardized 1% solution.

As a rule, 50 ml of Dioxidin is enough to rinse the nasal cavity and paranasal sinuses - 25 ml for each sinus. The procedure is carried out once a day. The course of treatment can be quite long - up to three weeks, and in severe cases, longer treatment is possible. For chronic sinusitis, repeated courses of nasal rinsing are prescribed, which are carried out 1–1.5 months after the initial treatment.

Before rinsing the nasal cavity, do not forget to monitor your nasal breathing: it should be free. If your nose is stuffy, you should take some drops and restore normal breathing. We discussed the details of the procedure in the article

Purulent diseases caused by bacteria are treated with Dioxidin, an antibacterial, bactericidal drug. It copes well with staphylococci and certain strains of bacteria that have developed resistance to other antibiotics. Purulent processes in the nasal sinuses sometimes require just such treatment.

Dioxidin for nasal rinsing

Dioxidin is quite common in the treatment of sinusitis in adults and children. Rinsing the nose helps get rid of mucus in the maxillary sinuses, because when it stagnates, inflammatory processes occur and the mucus turns into pus. By washing, we dilute this pathogenic substance and facilitate its removal from the cavities. It is logical that for rinsing you need to use Dioxidin in the form of a solution in the nose; it can be poured in using a syringe without a needle or with a syringe.

First, you need to prepare the solution. The question arises of how to dilute Dioxidin for nasal rinsing, and what the dosage should be. ENT doctors usually prescribe rinsing with a ready-made solution for intracavitary use. But if you are sensitive to the drug, you can dilute the ampoule to the prescribed consistency with water or sodium chloride solution.

Before starting the procedure, you need to thoroughly clean your nose and try to remove congestion. If this cannot be achieved by simply blowing your nose, you can use some kind of vasoconstrictor, for example:

• Tizin;
• Rinazolin.

And after a 5-minute break, we proceed directly to washing:

So, the process of rinsing the nose with Dioxidin is preceded by the introduction of vasoconstrictor drops and rinsing with saline solution. If you follow all these recommendations, you can expect a good result, since the drug copes with even the most persistent strains of bacteria and treats purulent inflammatory diseases of various etymologies.

Dioxidin nasal drops

If the case is not very advanced, you can not rinse it, but drip Dioxidin into your nose. For adults, the dosage is 1%. You need to instill 2-3 drops into each nostril. Before this, of course, you need to clear your nose of mucus and crusts, and only after that tilt your head back and administer the drug using a pipette. You need to repeat the procedure 2-3 times a day.

An opened ampoule of Dioxidin should be stored in the refrigerator with a cotton swab in the neck. Before instillation, the contents must be warmed to room temperature. After 24 hours it is necessary open a new ampoule.

Dioxidin can be instilled into the nose for no longer than 5 days. As a rule, the symptoms of an uncomplicated bacterial rhinitis disappear after four days.

The use of this drug brings quite noticeable positive results. However, you need to be careful and pay attention to your feelings. The consequences and side effects have not been studied in detail, and the dosages and duration of the course have been calculated empirically. The final decision on the use of the drug remains with the patient.