Modi diabetes - diagnosis and treatment. Hereditary forms of diabetes mellitus (diabetes mellitus type MODY) Is it possible to cure mody diabetes

Nutrition for kidney hemodialysis and diabetes excludes the consumption of saturated fats and easily digestible carbohydrates. When the “sweet disease” progresses, it affects almost all organ systems, causing various complications.

The most common consequence of the disease is chronic renal failure, which is the leading cause of death among diabetics. It occurs against the background of diabetic nephropathy - kidney dysfunction.

Diabetes mellitus is a pathology associated with metabolic disorders. When metabolic products and toxic substances accumulate in the blood of a healthy person, the kidneys cope with filtering it.

However, in diabetes, disruption of the paired organ leads to the accumulation of dangerous substances in the blood that poison the body. Therefore, doctors very often prescribe a procedure for artificial blood purification. How are hemodialysis and diabetes related? What meal regimen should you follow? Let's try to figure it out.

Kidney dysfunction in diabetes mellitus

The paired organ consists of more than 100 thousand “glomeruli” - special filters that free the blood from metabolic products and various toxins.

As blood passes through the small vessels of these filters, harmful substances are sent from the kidneys to the bladder, and fluid and vital components are returned back to the bloodstream. Then, with the help of the urethra, all waste is removed from the body.

Since diabetes mellitus is characterized by an increased glucose content, the load on the paired organ increases significantly. To remove excess sugar from the body, the kidneys require more fluid, resulting in increased pressure in each glomerulus.

Such pathogenic processes over time lead to a decrease in the number of active filters, which directly has a negative effect on blood purification.

When the “sweet illness” persists for a long time, the kidneys become so depleted that renal failure develops. Its main features are:

  • headache and fatigue;
  • diarrhea and bouts of vomiting;
  • shortness of breath even with little physical exertion;
  • skin itching;
  • metallic taste;
  • convulsions and spasms of the lower extremities, worse at night;
  • unpleasant odor from the mouth;
  • fainting and coma.

This condition develops after 15-20 years of ineffective diabetes treatment. To evaluate kidney function, your doctor may order a urine or blood test for creatinine, or a urine test for albumin or microalbumin.

Once the diagnosis is confirmed, the doctor may prescribe a blood purification procedure. Many experts agree that hemodialysis for diabetes requires special treatment. Thus, patients need to switch to a special insulin therapy regimen - injections of human insulin. The essence of this treatment is to cancel medium-duration hormone injections in the morning.

In addition, we must not forget about constant monitoring of glycemia in order to avoid other equally dangerous consequences.

The essence of the hemodialysis procedure

Sugar level

Hemodialysis is a procedure for extrarenal blood purification.

A special device filters the patient’s blood through a membrane, thus purifying it from various toxins and water. Therefore, the device is often called an “artificial kidney.”

The principle of operation of the device is as follows. Blood from the vein enters it, and the process of its purification begins.

Blood flows on one side of a special membrane, and dialysate (solution) flows on the other. It contains components that attract excess water and various toxins. Its composition is selected for each patient individually.

The “artificial kidney” has the following effects:

  1. Eliminates decay products. It should be noted that in the blood of a diabetic suffering from kidney failure, there is an increased concentration of toxins, proteins, urea and other things. However, there are no such substances in the dialysate. According to the laws of diffusion, all components from liquids with a high content of them move into a liquid with a low concentration.
  2. Eliminates excess water. This happens using ultrafiltration. Thanks to the pump, the blood passes through the filter under pressure, and in the flask that contains the dialysate, the pressure is low. Since the difference in pressure is quite large, excess fluid passes into the dialysate solution. This process prevents swelling of the lungs, brain and joints, and also removes fluid that accumulates around the heart.
  3. Normalizes pH. To stabilize the acid-base balance, a special sodium bicarbonate buffer is present in the dialysate solution. It penetrates into the plasma and then into red blood cells, enriching the blood with bases.
  4. Normalizes electrolyte levels. In order not to rid the blood of essential elements such as Mg, K, Na and Cl, they are contained in the same amount in the dialysate. Therefore, excess electrolytes go into solution, and their content is normalized.
  5. Prevents the development of air embolism. This action is justified by the presence of an “air trap” on the tube, which returns the blood back into the vein. As blood passes through, a negative pressure is created (from 500 to 600 mm Hg). The device traps air bubbles and prevents them from entering the blood.

In addition, the use of an artificial kidney prevents the formation of blood clots.

Thanks to heparin, which is administered using a pump, blood clotting does not occur.

Hemodialysis: indications and contraindications

This procedure is carried out 2-3 times every 7 days.

After undergoing hemodialysis, the percentage of efficiency of blood filtration, or rather the reduction in urea concentration, is determined.

When the procedure is carried out three times a week, this figure should be at least 65%. If hemodialysis is performed twice a week, the clearance percentage should be about 90%.

Hemodialysis therapy should be carried out only after the diagnosis has been determined and the treating doctor has agreed. The blood purification procedure is prescribed in the following cases:

  • with acute kidney failure resulting from acute glomerulonephritis, pyelonephritis and blockage of the urinary tract;
  • with chronic renal failure;
  • in case of drug poisoning (antibiotics, sulfonamides, sleeping pills, sedatives and others);
  • in case of intoxication with poisons (pale toadstool or arsenic);
  • in case of intoxication with methyl alcohol or ethylene glycol contained in alcohol;
  • with overhydration (excessive fluid content in the body);
  • in case of intoxication with narcotic drugs (morphine or heroin);
  • if there is an imbalance of electrolytes as a result of intestinal obstruction, cystic fibrosis, dehydration, burns, peritonitis or elevated body temperature.

However, the use of an “artificial kidney” even in the presence of one of these pathologies is not always necessary. A diabetic or patient with normal glucose levels is prescribed hemodialysis if:

  1. The daily volume of urine excreted is less than 0.5 liters.
  2. The kidneys perform their work only 10-15% and purify the blood in less than 200 ml in 1 minute.
  3. The urea content in the blood plasma exceeds 35 mmol/l.
  4. The concentration of potassium in the blood is more than 6 mmol/l.
  5. Standard blood bicarbonate is less than 20 mmol/L.
  6. Creatinine in blood plasma is more than 1 mmol/l.
  7. Swelling of the heart, lungs and brain cannot be eliminated with medications.
  • when infected with infections;
  • with the development of mental pathologies (schizophrenia, psychosis or epilepsy);
  • with a persistent increase in blood pressure;
  • after a stroke or myocardial infarction;
  • for malignant tumors;
  • with heart failure;
  • for blood diseases (leukemia and aplastic anemia);

In addition, hemodialysis is not used for people over 80 years of age.

Features of nutrition in diabetes and hemodialysis

A diabetic who has been diagnosed with kidney failure should consult a doctor about diet.

The nutritionist, taking into account the sugar level, the presence or absence of complications, duration of therapy, weight and age, develops a nutrition plan.

To maintain normal glucose levels and prevent deterioration of kidney function, the patient must adhere to all instructions of the attending physician.

The main nutritional rules for hemodialysis and the “sweet disease” are the following:

  1. Increasing protein intake to 1.2 g per 1 kg of body weight. The component is found in eggs, lean fish, meat and dairy products.
  2. The total amount of food consumed should not exceed 2500 kcal. This is how you can ensure the natural absorption of proteins.
  3. Limiting water intake. In the intervals between blood purification procedures, it is prohibited to consume more than 5% of the patient’s weight in liquid.

A balanced diet excludes the consumption of fat. Therefore, you will have to give up pork, lamb, mackerel, tuna, herring, sardines and salmon. In addition, you should not eat vegetables enriched with oxalic acid (rhubarb, spinach, celery, radishes, green onions and eggplants). You should forget about sausages, sausages, smoked meats and canned food. And, of course, give up sources of easily digestible carbohydrates, that is, sugar, chocolate, baked goods and other sweets.

Instead, you need to eat unsweetened fruits such as oranges, green apples, plums, lemons, etc. You should enrich your diet with fresh vegetables (tomatoes, cucumbers) and healthy cereals (barley, buckwheat and oatmeal).

Consumption of lean meat and fish (veal, chicken, hake) and low-fat fermented milk products is allowed.

Diet No. 7 for hemodialysis

This is used during hemodialysis to balance nutrition and prevent the development of side effects as a result of the blood filtration procedure.

Diet No. 7 is often called “renal”.

Its main principle is to limit the daily intake of potassium, protein and water.

There are several types of diet, but they all exclude the consumption of foods that include potassium and foods high in salt. However, the use of certain spices and sauces is allowed, which can compensate for the lack of salt.

According to diet No. 7, the following foods and dishes are allowed:

  • fruit and vegetable soups with the addition of potatoes, dill, parsley, butter, onions (boiled or sauteed);
  • bread, pancakes and pancakes without salt;
  • lean beef, trimmed pork, veal, rabbit, turkey, chicken (can be baked or boiled);
  • boiled lean fish, which can then be lightly fried or baked;
  • vinaigrette without salt, salads from fresh fruits and vegetables;
  • sauces and spices - tomato, milk, fruit and vegetable sauces, cinnamon, vinegar;
  • soft-boiled eggs twice a day, in the form of omelettes, yolks as part of dishes;
  • unsweetened fruits such as peach, orange, lemon, green apples;
  • cereals – pearl barley, corn;
  • milk, cream, sour cream, cottage cheese, curd dishes, fermented baked milk, kefir and yogurt;
  • teas without sugar, unsweetened juices, rosehip decoctions;
  • vegetable oil.

In addition to following a special diet, it is necessary to alternate work with proper rest. Emotional stress also plays an important role in kidney function and blood sugar levels.

During the diet, patients need to follow all the doctor’s recommendations in order to prevent various complications. In this case, self-medication is strictly prohibited, since the patient can only harm himself.

The video in this article will tell you in detail about the functioning of the kidneys in diabetes.

MODI diabetes is one of the most specific types of the presented condition. This form of pathology refers to Maturity Onset Diabetes of the Young, namely mature-type diabetes in young people. Exact data on the prevalence of the disease have not been established; approximately two to five percent of all patients with diabetes are concerned.

Main symptoms of MODI diabetes

The first clinical manifestations of MODY diabetes occur in children, adolescents and young adults. 50% of all cases are identified in girls during pregnancy, namely in the form of gestational diabetes.

MODY diabetes is associated with a significant list of symptoms that vary depending on the specific form of the pathology (this will be discussed below). Frequent urination and frequent skin problems occur. There is anemia, minor or more significant disorders associated with the nervous system, and long-term non-healing wounds. Symptoms and signs of the disease may be associated with:

  • blurry or unclear vision;
  • insufficiency of the pancreas;
  • muscle weakness;
  • weight changes, both upward and downward;
  • dehydration.

In addition, the child may develop problems related to the cardiovascular system and seizures. Occasional yeast infections, constant thirst, and diarrhea are likely. Dysfunctional damage to the kidneys and liver occurs quite often. These symptoms do not occur all at once, and therefore in order to determine which pathology is developing, it is necessary to understand the causes of the disease.

Reasons for the development of the disease

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The presented pathological condition is transmitted in a descending manner in 50% of cases if the defective gene turns out to be dominant. At the same time, the gender of the child does not matter. If problematic genes have been previously identified in two or more generations of the family, this should be considered an increased risk factor for the development of the disease in the child.

The causes of the disease are primarily mutations of genes that regulate the activity of the islet apparatus of the pancreas. Another factor should be considered pathological changes associated with the insulin-secreting activity of the beta cells of the gland. Such processes are provoked by hereditary pathologies.

Types of MODY diabetes

The classification of MODY diabetes is quite complex and includes eight types. By frequency of occurrence they are distributed in reverse order:

  • MODY-3 - the most common (70% of all cases);
  • MODY-2 - formed less frequently;
  • MODY-1 is the rarest form of the three presented (up to 1%);
  • other types of the disease are formed even less frequently, and therefore have no practical significance.

MODY-3 is characterized by the mildest onset between the ages of 20 and 40, the absence of ketoacidosis, that is, there is no smell of acetone from the mouth, as well as ketone bodies in the urine. Due to a violation of the renal barrier, elevated sugar is often identified in the urine, even with a normal ratio in the blood, and a long (longer than three years) “honeymoon” period is formed (a temporary decrease in the need for insulin).

Subtypes MODY-4, MODY-6, MODY-7 manifest themselves as a form of diabetes mellitus that does not have insulin dependence. However, they are extremely rare, and therefore practicing endocrinologists are not recommended to look for them, and symptomatic treatment is prescribed.

Diagnosis of any type of disease must be given special attention before starting a rehabilitation course.

Diagnostic methods

Reliable determination of a specific type of disease is only possible through molecular genetic research. We are talking about PCR, namely the polymerase chain reaction, which confirms the presence of mutations in a gene. The list of examinations includes identification of the ratio of glucose, insulin and C-peptide, glucose tolerance testing.

  • Diagnosis may involve the detection of autoantibodies to a variety of pancreatic beta cell antigens. You may also need:
  • determination of glycosylated hemoglobin to identify the severity and duration of hyperglycemia;
  • Ultrasound of the pancreas;
  • examination of urine for sugar levels, microalbumin;

identification of amylase in blood, urine, and fecal trypsin.

The next important diagnostic measure should be the blood lipid spectrum. It is mandatory to consult an ophthalmologist, namely to assess the condition of the fundus, because diabetes is characterized by complications specifically affecting the visual organs. Next, endocrinologists insist on genotyping (PCR) and coprogram. Only after a full diagnosis can we talk about a specific rehabilitation course.

Treatment of adult-onset diabetes in young people

The recovery course depends on the specific form of pathology. Usually, a balanced diet and normalization of metabolism are sufficient measures. Treatment with MODI-2 will not be effective without full physical activity, which has the most positive effect on the functioning of the pancreas.

  • Diabetes mellitus MODY can be treated by implementing measures such as:
  • introducing into the diet foods that help reduce blood sugar levels;
  • use of hypoglycemic medicinal names;
  • exclusion from the diet of such types of food as fried, fatty and too salty.

An important therapeutic and preventive measure is the abstinence of alcoholic beverages and the use of folk remedies, if they have been approved by an endocrinologist. For any type of diabetes, it is extremely important to evaluate the patient as early as possible. Such patients should visit an endocrinologist on a regular basis and also be registered with him, especially when it comes to children.

One of the most specific types of regular diabetes mellitus is the so-called modi diabetes. It belongs to hereditary forms of the pathological condition and has atypical symptoms. However, today the presented disease, which manifests itself in childhood, can be easily diagnosed and treated.

Characteristics of the disease

When talking about Modi diabetes, I would like to draw attention, first of all, to the fact that the presented abbreviation stands for when translated from English. The diagnosis is assessed as diabetes of the mature type in young people. In general, we are talking about a combined category of genetic pathologies with problematic functioning of the beta cells of the pancreas, which ensure the release of insulin. The exact prevalence of mody diabetes remains unknown. However, approximately we are talking about 2-5% of the total number of patients with diabetes.

Features of mody diabetes symptoms

Symptoms of the initial stage, indicating the development of the presented form of the disease, are identified in the following categories: young people, adolescents and children. Moreover, about 50% are detected in females during pregnancy as gestational diabetes. Experts draw attention to the fact that in order to make the presented diagnosis, the presence of disturbances in blood glucose levels in close relatives is important.

When talking about this, they mean direct relatives, which include father and mother, as well as grandparents. At the same time, mody diabetes is most often associated with such pathological conditions as diabetes mellitus itself and the presence of its gestational variety.

In addition, it is necessary to pay attention to the impaired degree of glucose tolerance and impaired glycemia on an empty stomach.

It is also necessary to take into account that there are quite a large number of varieties of this disease.

Varieties of the disease

To date, eight varieties of this form of the disease are known. According to frequency and degree of occurrence, they are distributed in reverse numerical order:

  • mody-3 - the most common (70% of the total number of cases);
  • mody-2 - is formed much less frequently;
  • mody-1 is the rarest of the three varieties presented, namely no more than 1%.

Other types of pathology occur even less frequently and therefore do not have any practical significance. Next, I would like to draw attention to how exactly Modi-3 differs from other forms of the disease. First of all, we are talking about a mild onset - with a minimum number of symptoms - in the age category from 20 to 40 years. In some cases, even later formation is likely, which exacerbates early diagnosis. In addition, when talking about mody diabetes mellitus, I would like to draw attention to the fact that traditionally the pathology is defined as type 1 diabetes and ketoacidosis is completely absent. In addition, the presence of sugar in the urine and the presence of vascular complications are likely.

Speaking about modi-2, diabetologists pay attention to the mildest course of the disease in a child among all types of the disease. However, it is quite difficult to diagnose because there are no symptoms or characteristic signs of type 2 diabetes. In this case, typical signs include prolonged moderate hyperglycemia on an empty stomach, as well as the fact that glycosylated hemoglobin levels do not exceed the upper limit of normal.

The modi-1 form of the disease is in last place of the three designated types of pathology. Its formation is associated with the mutation of certain genes, and therefore experts identify the similarity of symptoms with modi-3. The only exception should be considered the absence of any disorders in the renal metabolism.

In general, the classification of the disease is quite simple, but not always easy to identify.

As noted earlier, there are other types of modipathology. However, given their atypicality and the absence of pronounced symptoms, their diagnosis turns out to be a rather difficult process.

Main manifestations

Certain symptoms that may overlap with signs of type 1 or type 2 diabetes allow you to suspect the occurrence of the disease. However, subject to the implementation of certain surveys, they turn out to be obvious. In particular, you need to pay attention to:

  • early detection, namely before the age of 25;
  • absence of obesity or even minimal upward weight changes;
  • hereditary nature and the absence of the smell of acetone or the appearance of ketone bodies in the urine.

In addition, insulin secretion is preserved in such patients, and the absence of any antibodies against cells to the pancreatic area should also be considered characteristic. Experts pay attention to the possibility of long-term remission. It can last even more than one year and is not accompanied by stages of increasing sugar levels.

Experts call compensation based on the minimal need for a hormonal component, as well as the absence of any associations with certain antigens, as no less significant signs. In this case, special attention is paid to the features of the diagnostic examination, which allow each symptom to be correctly explained.

How is diabetes diagnosed?

Reliable identification of the disease is possible only through molecular genetic testing. It is this that makes it possible to confirm the presence of any mutations in certain genes. Taking this into account, I would like to note what a complete list of all necessary tests is. Of course, there is a need to identify the glucose ratio, test for tolerance to the component and identify autoantibodies.

In addition, a determination of glycosylated hemoglobin, an ultrasound scan of the pancreas and a urine examination for the presence of sugar are carried out. Further, it may be necessary to identify amylase in blood, urine and feces, and the lipid spectrum of the blood. No less significant stages of the examination are examination by an ophthalmologist and genotyping and coprogram. It is important to contact specialists or specialized centers to make the presented diagnosis.

Rehabilitation course

At the initial symptoms of the disease, it is strongly recommended to take care of the introduction of dietary nutrition, as well as the organization of optimal physical activity. Diabetologists point out that diabetes is highly treatable through special exercises or just physical exercise. It is acceptable to use yoga and breathing techniques.

As the pathological condition develops, it may become necessary to use medications that lower blood sugar levels. If they turn out to be ineffective, then the disease will be treated with regular insulin. It is very important not to self-medicate or use folk remedies. Only periodic consultations with a specialist will allow a person to maintain optimal functioning, as well as the absence of complications and critical consequences.

Thus, diabetes is a specific type of the disease, the main cause of which is certain changes in genes or even mutations. That is why it is strongly recommended to be attentive to both the diagnosis and the subsequent recovery course. This will help avoid worsening symptoms and other difficult situations that children may face.

Modern medicine has long made great strides in its development and can easily diagnose various diseases, including diabetes. Thanks to this, identifying it in the initial stages of development does not pose any problem even for inexperienced specialists who have just begun their journey to save people.

However, there is a certain form of the disease that even doctors who have considerable experience behind them cannot always diagnose. And this form of the disease is called diabetes, which will be discussed now.

General information

Even people far from medicine know that diabetes mellitus has 2 main types - first and second. The mechanism of their development is different, just like the treatment. Type 1 diabetes is a disease in which there is partial or complete dysfunction of the pancreas. Most often, it is a congenital disease and is “transmitted” to people by inheritance.

Type 2 diabetes is a disease in which the body's cells and tissues begin to lose their sensitivity to insulin. This happens due to the fact that they already have an excess of nutrients. And this happens in most cases against the background of obesity and poor nutrition.

Treatment for type 1 diabetes involves regular use of insulin injections, while for type 2 diabetes it is enough to simply follow simple dietary rules to prevent sudden surges in blood sugar levels.

Mody diabetes is a completely different form of the disease, the course of which does not generally fall under the standards characteristic of this pathology. In other words, with the development of this form of the disease, an increase in the concentration of sugar in the blood occurs, but no pathological processes or general deterioration in the patient’s well-being are observed.

As an example, we can provide repeated cases when in medical practice there was an increase in the concentration of glucose in the blood in young children for no apparent reason to 8 mmol/l or more, or when a child was diagnosed with T1DM in adolescence and for several He has been on the same dose of insulin for years, without his condition worsening.


Modi diabetes most often begins to manifest itself at an early age, and therefore it is very important from birth to regularly measure blood glucose levels in children

To put it simply, in young diabetics the course of the disease is completely asymptomatic and not burdensome, as in older people with T2DM. It is in such situations that we talk about the development of a disease such as diabetes.

And it should be noted that this form of the disease is diagnosed in 5% of people who have been diagnosed with diabetes. And most of them are children. But due to the fact that due to its asymptomatic course, diabetes is very difficult to detect and the statistical data provided by WHO differ significantly from reality. So what is diabetes and why does it develop?

What it is?

The full name of this disease is Maturity Onset Diabetes of the Young. Translated from English, it is translated as mature-type diabetes in young people. American scientists first mentioned this disease back in 1975. They presented it as a weakly progressive form of diabetes mellitus in children and young people with a hereditary predisposition to this disease.

The development of pathology occurs as a result of a gene mutation that occurs against the background of disruption of the pancreas. Such disorders can make themselves felt both at birth and during adolescence, when hormonal disruptions occur in the body. However, it is possible to identify the presence of gene mutations and the development of diabetes only by conducting a molecular genetic study.

Thanks to this study, it is possible to determine exactly which gene was mutated in a child during intrauterine development. And since scientists have identified 8 genes, the mutation of which leads to the development of this type of pathology, then, accordingly, the mutation of each gives a completely different clinical picture and requires a different approach to treatment.

How can the disease manifest itself?

It is very difficult to suspect the development of diabetes in children and young people, since it is mild and does not have pronounced symptoms. However, often the occurrence of this pathology can be similar to the symptoms that occur with type 1 diabetes, accompanied by the following signs:

  • the onset of the so-called diabetic honeymoon, which is characterized by a long stage of remission (more than 1 year) and the absence of decompensation (deterioration in the functionality of internal organs and systems with a parallel deterioration in general well-being);
  • absence of ketones in the blood during the acute phase of the disease;
  • identifying the full functioning of the pancreas and normal insulin synthesis, which is checked by taking a blood test (with normal insulin levels, the concentration of C-peptide in the blood also remains within normal limits);
  • reducing sugar and maintaining it in normal quantities for a long time is achieved by using minimal doses of insulin;
  • When tested, antibodies to beta cells and insulin are not detected;
  • there is no association with the HLA system;
  • glycated hemoglobin levels remain normal.

A diagnosis of “modidiabetes” can be made without any consequences if a person has a hereditary predisposition to diabetes or his mother was diagnosed with gestational diabetes during pregnancy. The doctor may also suspect the development of this disease after receiving the results of a test that showed that the patient has impaired cell tolerance to glucose in the body.

Often, the doctor prescribes an additional examination in cases where a person whose age does not exceed 25 years has been diagnosed with type 2 diabetes. However, he does not have any signs of illness and is not obese.

Since diabetes often occurs without a pronounced clinical picture, all parents, without exception, must constantly monitor the condition of their child. A cause for concern is the periodic appearance over several years of symptoms such as:

  • the presence of fasting hyperglycemia, when the blood sugar level rises to 8.5 mmol/l, but there are no signs such as frequent urination, weight loss and polydipsia;
  • detection of impaired tolerance of body cells to carbohydrates (detected by taking a blood test).

It should be noted that when diabetes occurs, children rarely complain about a deterioration in their general health, since the disease does not have pronounced clinical manifestations. This is the whole difficulty in making a diagnosis. But if you miss the moment and do not start treatment on time, the disease can go into a decompensated form and it will be almost impossible to overcome it.

Therefore, young children who have a hereditary predisposition to diabetes should have their blood glucose levels measured regularly. And if the indicators begin to change and go beyond normal limits, you should immediately seek help from a doctor, even if there are no other signs of developing diabetes.


Only a doctor can make the correct diagnosis after receiving the results of all the necessary tests.

Types of diabetes

As mentioned above, there are eight genes that can mutate and trigger the development of diabetes. However, this disease is divided into only 6 forms and they all have their own characteristics. Each type of mody diabetes is called: mody-1, mody-2, mody-3, etc.

It is believed that the most benign form of the disease is mody-2. With its development, fasting hyperglycemia occurs extremely rarely, and the development of such a concomitant condition as ketoacytosis is almost never recorded. At the same time, there are also no other signs of the development of diabetes mellitus. As world statistics show, the largest number of people who have been diagnosed with mody-2 diabetes live in France and Spain. Scientists have not yet been able to identify what this is connected with.


Since diabetes is practically asymptomatic, the need for insulin injections is extremely rare.

With the development of this form of the disease, minimal dosages of insulin allow one to achieve a compensatory state. Since the disease does not cause significant discomfort to the patient and does not affect his quality of life, the need to increase the dosage of insulin almost never arises.

Mody-3 is most often diagnosed in residents of European countries, namely Holland and Germany. As a rule, this disease begins to develop in children over 10 years of age and often leads to severe complications.

But mody-1 is the rarest form of pathology and is detected in only 1% of people suffering from diabetes. The disease is very severe and often leads to death. But mody-4 is most common in adolescents aged 15–17 years. There are suggestions that the main impetus for its development is hormonal disorders in the body, but this has not yet been proven by official medicine.

Mody-5 in its clinical picture is similar to the development of mody-2, but unlike this form of the disease, it often leads to the development of a complication such as diabetic nephropathy.

How is the pathology treated?

Due to the fact that pancreatic dysfunction is not observed during the development of diabetes, treatment is generally the same as for T2DM. That is, at the very beginning of the development of the disease, the patient is prescribed a low-carbohydrate diet and moderate physical activity. This allows you to normalize blood sugar levels and prevent the occurrence of hyperglycemia.

In addition, other treatment methods can be used as therapeutic therapy. For example, many patients who have been diagnosed with diabetes can achieve stable compensation through breathing exercises and yoga. They are carried out exclusively under the strict supervision of a specialist.


Moderate physical activity for diabetics allows you to achieve stable compensation

Alternative medicine produces equally bad results. However, doctors do not recommend using folk remedies as the main therapy, since each person’s body is individual and sometimes they do not give the expected effect, and the progression of the disease continues.

It is for this reason that only a doctor should treat diabetes. Even if the patient chooses alternative medicine as therapy, he must agree with a specialist.

It should be understood that if you miss the moment when stable compensation can be achieved, there will be a need for constant use of sugar-lowering drugs and insulin injections. And this is not only expensive, but also inconvenient.

Last updated: October 7, 2019

Diabetes mellitus is widely divided into types 1 and 2. Type 1 We usually associate it with the onset of the disease at a young age and an autoimmune process that destroys the beta cells of the pancreas, responsible for the production of insulin.

Type 2 begins, as a rule, at a later age and has a close relationship with obesity. There are also other types of diabetes. type MODY (Maturity Onset Diabetes of the Young) and type LADA (Latent Autoimmune Diabetes in Adults).

Hormones for diabetes

Common feature of all types of diabetes Hyperglycemia (high blood sugar) is caused by defects in the release or action of insulin.

Risk factors for diabetes include:

  • overweight and obesity;
  • low physical activity;
  • prevalence of diabetes mellitus in the family;
  • isolated cases of deviations in glucose levels on an empty stomach or after meals;
  • pregnancy;
  • birth of a child weighing more than 4 kg;
  • hypertension.

Symptoms of type 1 diabetes

Quite often it happens that the reserves of pancreatic cells are depleted quickly and the first sign of the disease is coma. Suddenly, nausea, vomiting, abdominal pain and aversion to food appear.

Unquenchable thirst and difficulty breathing are added. A very characteristic way of breathing appears - significantly accelerated and deep breaths (like the breathing of a running dog). There is an unpleasant smell of acetone coming from the mouth. Weakness continuously progresses and reaches loss of consciousness and coma. Absence diabetes treatment type 1 can cause death.

Symptoms of type 2 diabetes

The most common type of diabetes is type 2 diabetes. It belongs to 7% of society in our country, but the number of patients is constantly increasing. As a rule, people over 30 years of age get sick with it. The incidence increases with age up to 70 years and then decreases.

Type 2 diabetes, known as non-insulin dependent diabetes, is expressed by disturbances in both the action and secretion of insulin. The tendency to diabetes of this type can be inherited from parents. But factors that depend on us are of great importance. The most important of these is abdominal obesity, which causes resistance of body tissues to the action of insulin.

Glucose enters cells with difficulty, and its concentration in the blood increases. This stimulates the pancreas to produce even more hormone. After some time, its reserve is depleted, beta cells undergo degradation. The amount of insulin decreases, but resistance to its action remains.

Hyperglycemia occurs and the first symptoms appear. Lack of exercise, often accompanied by obesity, exacerbates this problem by preventing the use of glucose in energy processes.

Diabetes mellitus type LADA

Diabetes mellitus LADA is an abbreviation for “Latent Autoimmune Diabetes in Adults”, which means diabetes of autoimmune origin that develops at a later age (35-45 years).

The destruction of cells occurs gradually and appears only at the age of 35-45 years and even later, and not in childhood. This creates difficulties for diagnosing diabetes, but we must remember that making a correct diagnosis is very important, because LADA requires strict insulin therapy.

Attempted therapy with oral medications is ineffective and can lead to very rapid development of complications, such as damage to the kidneys, vision, and even diabetic coma, which is life-threatening.

Diabetes mellitus LADA may be suspected in a person between 30 and 60 years of age whose diabetes is not accompanied by obesity or hypertension. Also, the lack of prevalence of type 2 diabetes in the patient’s family may raise doubts among the doctor.

To unravel the mystery of the disease, a diabetologist may order tests for the level of antibodies to GAD, because their presence in the blood confirms the diagnosis of LADA. It is also possible to examine C-peptide, the concentration of which in the blood is low in this case.

Diabetes mellitus type MODY

MODY comes from the English expression “Maturity Onset Diabetes of the Young”, which can be understood as type 2 diabetes (that is, correct for older people), but starting at an early age (as type 1).

MODY accounts for about 5% of all diabetes cases. The cause of this disease is insulin secretion disorders at the genetic level. It develops approximately between the 15th and 35th years of life, but sometimes even in childhood. May coexist with congenital malformations, for example of hearing, urinary tract or nervous system.

Defects in various genes can lead to the development of MODY, which leads to different patterns of inheritance, for example, autosomal dominant (if one parent is sick, then the risk that his children will be sick is 75%) or mitochondrial (only the mother can pass on defective genes to the offspring) .

The diagnosis of MODY involves the possibility of initial treatment with oral medications, such as sulfonylureas, although insulin therapy may be required over time, as with type 2 diabetes.

Diagnosis of MODY makes it possible to predict the future health of children and delay the start of insulin therapy, which has its side effects. In addition, the fact of the existence of this type of diabetes may prompt a search for congenital defects that accompany it, and attempts to eliminate the consequences, for example, treatment of defects of the genitourinary system in order to prevent kidney failure.

Diabetes mellitus LADA and diabetes MODY develop relatively rarely - together they account for only a few percent of cases of diabetes, but it is not worth remembering their existence in the case of a not entirely clear and atypical course of the disease, because making a correct diagnosis determines appropriate and effective therapy, which, as far as possible, will delay the appearance of complications.