Frequent and painful urination, accompanied by pain in the lower abdomen, is most often a sign of the development of cystitis. The most effective way to treat this disease is to take a course of antibiotics. The drug Monural shows excellent results in the treatment of cystitis, but there are also budgetary domestic drugs with a similar effect and composition.
Monural
Monural is one of the most effective antibiotics for the treatment of acute diseases of the genitourinary system. This antibiotic is quickly absorbed by the body, so the positive effect of taking it appears quickly enough and a single use is enough.
Method of administration: Dissolve 1 sachet of Monural in ⅓ glass of water. Take once a day on an empty stomach, several hours before meals, after emptying the bladder.
Side effects:
Contraindications: age less than 5 years, allergy to the components of the drug, renal failure, women who are breastfeeding.
Analogs for the active substance
There are a large number of domestic analogues of Monural, which are produced on the basis of fosfomycin. These include:
Ureacid
Release form: granules in a sachet for the preparation of a solution for oral administration.
Active ingredient: 1 sachet contains 3 grams of fosfomycin trometamol, calculated as fosfomycin.
An antimicrobial antibacterial agent that is suitable for adults and children over 12 years of age. Ureacid is used to treat simple infections caused by microorganisms sensitive to fosfomycin.
Directions for use: The contents of one sachet should be poured into ½ glass of cold water, stir until completely dissolved and drink immediately.
Typically, a single dose for adults, including elderly patients in the acute phase of the disease is 3 grams (1 sachet) once.
Side effects: disruption of the gastrointestinal tract, heartburn, nausea, diarrhea.
Contraindications: hypersensitivity to the components of the drug, renal failure, increased creatinine levels in the blood and urine.
Urolysin
Release form: granules for oral use.
Active ingredient: birch leaf extract, knotweed herb, horsetail herb, kholmovoy solyanka herb, Kuril tea, chokeberry fruits, blueberry shoots, burdock roots, glucose.
The drug is suitable for the treatment of simple urinary tract infections and for prophylaxis during diagnostic procedures and surgical interventions. The age category ranges from 12 to 75 years.
Directions for use: Dissolve 1 teaspoon of granules in 100 milliliters of warm water and take 3 times a day. The course of treatment is 4-6 weeks. After 2 weeks, repeat the course.
Use with caution in case of large stones in the kidneys and gall bladder during exacerbations of urinary and cholelithiasis, more than 4 times a year.
Side effects: disorders of the gastrointestinal tract.
Contraindications: individual intolerance to components, diabetes mellitus, breastfeeding period, pregnancy.
Urophosphabol
Release form: powder for the preparation of a solution for intravenous administration, white or white with a yellowish tint.
Active ingredient: Fosfomycin.
It is used for infectious and inflammatory processes of the pelvic organs and exacerbations of diseases of the genitourinary system. Suitable for any age group, starting with newborns. Minimally toxic.
Directions for use: it is necessary to prepare a solution for intravenous infusion. The cooking method will vary depending on the disease. Details can be found in the instructions inside the box with the drug.
Side effects: cramps, dizziness, diarrhea, chills, itching, skin irritation.
Contraindications: increased sensitivity to fosfomycin, predisposition to allergic reactions, with liver diseases, with renal failure, with heart failure, with arterial hypertension.
Fosmicin
Broad-spectrum antibiotic for systemic use in the form of powder for intravenous injection. Prescribed for the treatment of bacterial infections of the genitourinary system, gynecological and surgical infections. Prohibited for use by children under 5 years of age.
Directions for use:
Side effects:
Contraindications:
Fosfomycin
Release form: powder for the preparation of solutions for intravenous infusions.
Active ingredient: Fosfomycin, Trometamol.
It is a broad-spectrum antibiotic. It is used in the treatment and prevention of diseases of the genitourinary system, acute bacterial cystitis, exacerbation of chronic recurrent bacterial cystitis, acute bacterial urovesical syndrome, bacterial nonspecific urethritis, asymptomatic massive bacteriuria.
Directions for use: The application regimen is established individually for all ages and various diseases. Detailed instructions for preparing solutions for infusions can be found inside the package with the drug.
Side effects: rarely appear
Contraindications: hypersensitivity to fosfomycin, pregnancy and lactation.
Fosfomycin trometamol
Active ingredient: Fosfomycin, Trometamol.
A drug with a high antimicrobial effect for the treatment of acute cystitis caused by Escherichia coli resistant to other drugs. Suitable for adults and children over 5 years old.
Directions for use: The drug is used once after emptying the bladder, on an empty stomach, preferably before bedtime. For adults, the dosage is 3 grams, for children over 5 years old – 2 grams.
Side effects: Nausea, vomiting, diarrhea, and skin rash rarely occur, disappearing on their own after discontinuation of fosfomycin.
Contraindications: hypersensitivity to fosfomycin, pregnancy and lactation.
Fosfomycin Esparma
Release form: granules (powder) for solution (suspension).
Active ingredient: Fosfomycin, Trometamol.
A broad-spectrum antibacterial agent in the form of a white powder with a fruity odor for oral administration. Used for the treatment of infectious and inflammatory diseases of the lower urinary tract. Not recommended for use by children under 12 years of age. Dispensed by prescription.
Directions for use:
Side effects: Nausea, vomiting, diarrhea, and skin rash rarely occur, disappearing on their own after discontinuation of fosfomycin.
Contraindications: hypersensitivity to fosfomycin, pregnancy and lactation.
Phosphoral Rompharm
Release form: granules (powder) for solution (suspension).
Active ingredient: Fosfomycin, Trometamol.
Broad-spectrum antibiotic for the treatment of acute uncomplicated diseases of the genitourinary system. Also used for prophylaxis during diagnostic procedures and surgical interventions.
Directions for use: taken orally. A single dose for adults is 3 grams, for children – 2 grams. The treatment regimen is established individually, taking into account the stage of the inflammatory process, the reactivity of the patient’s body, and the sensitivity of microorganisms to fosfomycin.
Side effects: nausea, vomiting, diarrhea, skin rash, which disappears on its own after discontinuation of fosfomycin.
Contraindications: hypersensitivity to fosfomycin, pregnancy and lactation.
Ecomural
Release form – granules for the preparation of solution for oral administration (packages) 2 grams, 3 grams.
Active ingredient: Nifuroxazide 100 milligrams, Fosfomycin.
Contains antibiotic, probiotic and fosfomycin. Used for the treatment of acute and chronic cystitis and for various diseases of the urinary tract. Suitable for adults and children over 12 years old.
Directions for use: consumed once, orally, on an empty stomach. The packet of granules should be dissolved in 100 milliliters of water and drunk. The drug can be used by infants only under medical supervision and in special cases.
Side effects: nausea, vomiting, diarrhea, skin rash, which disappears on its own after discontinuation of fosfomycin.
Contraindications: hypersensitivity to fosfomycin, pregnancy and lactation.
Analogues by mode of action
These drugs affect the body in a similar way as Monural.
Amoxicillin
Release form: capsules of 0.5 milligrams for oral use.
Active ingredient: Amoxicillin.
Broad-spectrum penicillin antibiotic. Available in the form of capsules (orally) and granules for suspension. Used to treat infectious diseases. Suitable for adults and children over 12 years old. The course of treatment is from 5 to 12 days.
Directions for use: adults and children over 12 years of age take 500 milligrams 3 times a day.
Side effects: dizziness, ataxia, allergic reactions, skin itching. skin redness, fever, rhinitis, conjunctivitis, anaphylactic shock.
Contraindications: infectious mononucleosis, lymphocytic leukemia, severe gastrointestinal infections accompanied by diarrhea or vomiting,
respiratory viral infections, allergic diathesis, bronchial asthma, hay fever, hypersensitivity to penicillins and/or cephalosporins.
Nolitsin
Release form: tablets (400 mg of norfloxacin in 1 tablet), 10 and 20 pieces in 1 package, coated in an orange coating.
Active ingredient: Norfloxacin.
Broad-spectrum antibiotic. Release form: tablets. It is used to treat infectious and inflammatory processes of the abdominal cavity and pelvic organs. It has a fairly large number of side effects. The course and dose of treatment is prescribed by the doctor.
Directions for use: for mild cystitis, a 3-day course of Nolitsin is needed (1 tablet 2 times a day every 12 hours).
Side effects: nausea, vomiting, arrhythmia, headache, tinnitus, depression, allergic reactions.
Contraindications: individual intolerance to fluoroquinolone antibiotics, pregnancy, breastfeeding, congenital deficiency of the enzyme glucose-6-phosphate dehydrogenase, age under 18 years.
Urolesan
Release form: syrup in glass bottles of 15 milliliters, in the form of tablets or capsules.
Active ingredient: Trilon-B and essential oils.
A bactericidal drug is used:
- with stones in the bladder;
- with stones in the gall bladder;
- with salt diathesis;
- with pyelonephritis in acute or chronic form;
- with cholecystitis;
- during inflammatory processes in the tissues of the liver and bile ducts;
- with dyskinesia of the gallbladder.
Directions for use: Adults and children take 1 capsule or 10 milliliters of syrup, 3 times a day before meals.
Side effects: nausea, dizziness, heartburn, diarrhea.
Contraindications: individual intolerance to the components of the drug, stomach and intestinal ulcers, glomerulonephritis, gastritis of all forms.
Urfocin
Release form – granules for the preparation of solution for oral administration (packages) 3 grams.
Active ingredient: Fosfomycin.
Ukrainian broad-spectrum antibiotic for systemic use. Suitable for the treatment of simple urinary tract diseases. Indicated for adults and children over 12 years of age.
Directions for use: Dissolve 1 sachet of the drug in ⅓ glass of water. Take once a day on an empty stomach, several hours before meals, after emptying the bladder.
Use during pregnancy and lactation only under the supervision of a physician.
Side effects: heartburn, nausea, diarrhea, headache, skin rash.
Contraindications: age less than 12 years, allergy to the components of the drug, renal failure, women who are breastfeeding.
Phytozolin
Release form: paste for oral use, 100 g in metal (aluminum) tubes.
The active ingredient is aqueous extracts from onion peel, wheatgrass root, parsley fruit, knotweed herb, horsetail herb, birch leaves, fenugreek seeds, goldenrod herb, hernia herb, lovage root.
A herbal preparation based on hydroalcoholic extracts of herbs and essential oils. Used to treat chronic diseases of the urinary system.
Directions for use: apply 1 teaspoon of paste 3-4 times a day. The course of treatment is from 2 to 6 weeks.
Side effects: nausea, diarrhea, vomiting, skin rashes, temporary loss of taste.
Contraindications: individual intolerance, children under 15 years of age, pregnant and lactating women.
Furadonin
Release form: tablets of 100 milligrams.
Active ingredient: Nitrofurantoin.
A drug that is used to treat bacterial cystitis and chronic inflammation of the bladder.
Directions for use: Take 50-100 milligrams of the drug 3-4 times a day. You need to take the tablet with plenty of liquid.
Side effects: allergies, cough, shortness of breath, itching and redness of the skin, drowsiness, headaches, nausea, loss of appetite, vomiting.
Contraindications: increased sensitivity to fosfomycin, predisposition to allergic reactions, with liver diseases, with renal failure, with heart failure, with arterial hypertension, with cirrhosis, with hepatitis, with lactation.
This page provides a list of all Monural analogues by composition and indication for use. A list of cheap analogues, and you can also compare prices in pharmacies.
- The cheapest analogue of Monural:
- The most popular analogue of Monural:
- ATX classification: Fosfomycin
- Active ingredients/composition: fosfomycin
Cheap analogs of Monural
When calculating the cost cheap analogs of Monural the minimum price was taken into account, which was found in the price lists provided by pharmacies
Popular analogs of Monural
Given list of drug analogues based on statistics of the most requested drugs
All analogues of Monural
Analogues in composition and indications for use
| Name | Price in Russia | Price in Ukraine |
|---|---|---|
| fosfomycin | -- | -- |
| fosfomycin | 10500 rub. | 484 UAH |
| fosfomycin | -- | 134 UAH |
| fosfomycin | 118 RUR | 42 UAH |
| fosfomycin | 2100 rub. | -- |
| fosfomycin | -- | 158 UAH |
| fosfomycin | 352 RUR | 96 UAH |
| fosfomycin | 122 rub. | -- |
| fosfomycin | -- | 288 UAH |
The above list of drug analogues, which indicates Monural substitutes, is the most suitable because they have the same composition of active ingredients and coincide in indications for use
Analogues by indication and method of use
| Name | Price in Russia | Price in Ukraine |
|---|---|---|
| 262 RUR | 295 UAH | |
| bacteriophages | -- | -- |
| bacteriophages | 834 RUR | -- |
| bacteriophages | -- | 89 UAH |
| bacteriophages | -- | -- |
| dioxidine | -- | -- |
| dioxidine, lidocaine | -- | 33 UAH |
| spectinomycin | 263 RUR | 47 UAH |
| spectinomycin | -- | 77 UAH |
| glyceryl trinitrate | -- | 78 UAH |
| nitroxoline | 27 rub. | 2 UAH |
| nitroxoline | 172 RUR | 117 UAH |
| nitroxoline | -- | -- |
| nitroxoline | -- | 1 UAH |
| linezolid | 4 rubles | 704 UAH |
| linezolid | -- | 669 UAH |
| linezolid | -- | 522 UAH |
| linezolid | -- | 782 UAH |
| linezolid | -- | 194 UAH |
| linezolid | -- | -- |
| linezolid | -- | 430 UAH |
| linezolid | -- | -- |
| linezolid | 5900 rub. | -- |
| linezolid | 141 RUR | -- |
| linezolid | -- | -- |
| linezolid | -- | -- |
| daptomycin | RUR 347 | 2326 UAH |
| tedizolid | 4500 rub. | -- |
| dioxidine | 12 rub. | 7 UAH |
Different composition, may have the same indication and method of use
| Name | Price in Russia | Price in Ukraine |
|---|---|---|
| 45 rub. | 111 UAH | |
| vancomycin | -- | 124 UAH |
| 36 rub. | -- | |
| vancomycin | 5800 rub. | 297 UAH |
| vancomycin | -- | -- |
| vancomycin | -- | -- |
| vancomycin | -- | 157 UAH |
| vancomycin | -- | -- |
| vancomycin | -- | 97 UAH |
| vancomycin | -- | -- |
| vancomycin | -- | -- |
| vancomycin | 141 RUR | -- |
| vancomycin | -- | -- |
| teicoplanin | -- | 339 UAH |
| teicoplanin | 3580 rub. | 577 UAH |
| teicoplanin | -- | -- |
| teicoplanin | -- | 361 UAH |
| telavancin | -- | -- |
| colistimethate sodium | -- | 340 UAH |
| colistimethate sodium | 590 RUR | 2832 UAH |
| polymyxin B | -- | -- |
| polymyxin B | -- | -- |
| sodium fusidate | -- | -- |
| tenonitrozole | 320 rub. | 87 UAH |
| metronidazole | -- | 7 UAH |
| metronidazole | -- | -- |
| metronidazole | 7 rub | 10 UAH |
| metronidazole | 10 rub | 5 UAH |
| metronidazole | 64 rub. | 23 UAH |
| metronidazole | -- | 16 UAH |
| metronidazole | -- | -- |
| metronidazole | -- | 14 UAH |
| metronidazole | -- | 17 UAH |
| metronidazole | -- | 10 UAH |
| metronidazole | -- | -- |
| metronidazole | -- | -- |
| tinidazole | 28 rub. | 10 UAH |
| tinidazole | -- | 29 UAH |
| tinidazole, MCC, crospovidone, corn starch, magnesium stearate | -- | -- |
| ornidazole | -- | 58 UAH |
| ornidazole | -- | 47 UAH |
| ornidazole | -- | 34 UAH |
| ornidazole | 12 rub. | 17 UAH |
| ornidazole | -- | 37 UAH |
| ornidazole | 45 rub. | -- |
| ornidazole | -- | 49 UAH |
| ornidazole | -- | 44 UAH |
| ornidazole | -- | -- |
| ornidazole | -- | -- |
| ornidazole | -- | 35 UAH |
| ornidazole | -- | 71 UAH |
| ornidazole | -- | -- |
| ornidazole | -- | 44 UAH |
| ornidazole | -- | 92 UAH |
| ornidazole | -- | -- |
| ornidazole | 159 RUR | 150 UAH |
| ornidazole | -- | -- |
| nitrofurantoin | 16 rub. | 25 UAH |
| nitrofurantoin | 45 rub. | -- |
| furazidine | 20 rub | 12 UAH |
| furazidine | 240 rub. | 8 UAH |
| furazidine | 441 RUR | 8 UAH |
| furazidine | 317 RUR | -- |
| furazidine | 258 RUR | 63 UAH |
To compile a list of cheap analogues of expensive drugs, we use prices that are provided to us by more than 10,000 pharmacies throughout Russia. The database of drugs and their analogues is updated daily, so the information provided on our website is always up to date as of the current day. If you have not found the analogue you are interested in, please use the search above and select the medicine you are interested in from the list. On the page of each of them you will find all possible analogues of the drug you are looking for, as well as prices and addresses of pharmacies where it is available.
How to find a cheap analogue of an expensive medicine?
To find an inexpensive analogue of a medicine, a generic or a synonym, first of all we recommend paying attention to the composition, namely the same active ingredients and indications for use. The same active ingredients of a drug will indicate that the drug is a synonym for the drug, pharmaceutically equivalent or a pharmaceutical alternative. However, we should not forget about the inactive components of similar drugs, which may affect safety and effectiveness. Do not forget about the instructions of doctors; self-medication can harm your health, so always consult a doctor before using any medication.Monural price
On the websites below you can find prices for Monural and find out about availability at a pharmacy near you
Description.
White granules with a tangerine scent.Pharmacotherapeutic group antibiotic
ATX code J01XX01 .
Pharmacological properties
Pharmacodynamics
The active substance of Monural® - fosfomycin trometamol - is a broad-spectrum antibiotic, a derivative of phosphonic acid.
Monural® has a bactericidal effect. The mechanism of action is associated with the suppression of the first stage of bacterial cell wall synthesis. Being a structural analogue of phosphoenol pyruvate, it enters into a competitive interaction with the enzyme N-acetyl-glucosamino-3-o-enolpyruvil transferase, resulting in specific, selective and irreversible inhibition of this enzyme, which ensures the absence of cross-resistance with other classes of antibiotics and the possibility synergism with other antibiotics (in vitro synergy with amoxicillin, cephalexin, pipemidic acid has been noted). The antibacterial spectrum of action of fosfomycin trometamol in vitro includes most of the usual gram-positive (Enterococcus spp., Enterococcus faecalis, Staphylococcus aureus, Staphylococcus saprophyt., Staphylococcus spp.) and gram-negative (E. coli, Citrobacter spp., Enterobacter spp., Klebsiella spp., Klebsiella pneumoniae, Morganella morganii, Proteus mirabilis, Pseudomonas spp., Serratia spp.) pathogens. In vitro, fosfomycin trometamol reduces the adhesion of a number of bacteria to the epithelium of the urinary tract.Pharmacokinetics
Absorption: Monural® is rapidly absorbed from the gastrointestinal tract when taken orally.
In the body it dissociates into fosfomycin and trometamol. The latter does not have antibacterial properties. Bioavailability after a single oral dose of 3 g ranges from 34 to 65%. The maximum plasma concentration is observed 2-2.5 hours after oral administration and is 22-32 mg/l. The half-life from plasma is 4 hours.
Distribution: Monural® does not bind to plasma proteins, is not metabolized, and predominantly accumulates in the urine. When a single dose of 3 g is taken orally, a high concentration is achieved in urine (from 1053 to 4415 mg/l), 99% bactericidal for most common pathogens of urinary tract infections. The minimum inhibitory concentration of Monural® for these pathogens is 128 mg/l. It is maintained in urine for 24-48 hours, which requires a single-dose course of treatment. Concentrations of Monural® in urine above the minimum inhibitory concentration for E. coli persist for at least 80 hours.
Excretion: Monural® is 90% excreted unchanged by the kidneys, creating high concentrations in the urine. About 10% of the dose taken is excreted unchanged through the intestines. In patients with moderately reduced renal function (creatinine clearance< 80 мил/мин), включая ее физиологическое снижение у лиц пожилого возраста, период полувыведения фосфомицина немного удлиняется, но концентрация в моче остается на терапевтическом уровне.Indications for use
· acute bacterial cystitis, acute attacks of recurrent bacterial cystitis;
· bacterial nonspecific urethritis;
· asymptomatic massive bacteriuria in pregnant women;
· postoperative urinary tract infections;
· prevention of urinary tract infections during surgery and transurethral diagnostic studies.Contraindications
Individual hypersensitivity to fosfomycin trometamol, severe renal failure (creatinine clearanceUse during pregnancy and lactation
During pregnancy, the drug is prescribed only when the potential benefit to the mother outweighs the potential risk to the fetus.
If it is necessary to prescribe the drug during lactation, breastfeeding should be stopped during treatment.Directions for use and doses
Inside.
The granules are dissolved in 1/3 cup of water. Monural® is used once a day orally on an empty stomach 2 hours before or after meals, preferably before bedtime, after emptying the bladder.
Adults are prescribed 1 packet (3 g) 1 time per day.
In order to prevent urinary tract infections during surgery and transurethral diagnostic procedures, take Monural® twice in the doses indicated above: 3 hours before the intervention and 24 hours after the intervention.
Children from 5 years to 18 years are prescribed a daily dose of 2 g 1 time per day.
The course of treatment is 1 day.
In more severe cases (elderly patients, recurrent infections), take another 1 packet every 24 hours.
In case of renal failure, reduce the dose and lengthen the intervals between doses.Side effect
Possible disorders of the gastrointestinal tract (nausea, heartburn, diarrhea), skin rash, allergic reactions.Overdose
Overdose symptoms: diarrhea. If persistent diarrhea occurs, symptomatic treatment is recommended.
The risk of overdose is minimal, since Monural® is available in 1 or 2 packets. In case of overdose, it is recommended to take fluids orally to increase diuresis.Interaction with other drugs
Concomitant use with metoclopramide should be avoided, as this may lead to a decrease in the concentration of Monural® in the blood serum and urine.Special instructions
Simultaneous food intake slows down the absorption of Monural® - it is necessary to use the drug 2 hours before or after meals.
Patients with diabetes mellitus should take into account that 1 package of Monural® with a dosage of 2 g or 3 g of fosfomycin contains 2.100 g or 2.213 g of sucrose, respectively.Release form
Granules for the preparation of oral solution 2 g and 3 g.
6 g or 8 g of the drug are placed in bags of 4-layer laminated foil (paper-polyethylene-aluminum-polyethylene). 1 or 2 packets are placed in a cardboard box along with instructions for use.Storage conditions
List B. Store at a temperature not exceeding 30 ºС.
Keep out of the reach of children.Best before date
3 years.
Do not use after the expiration date stated on the packaging.Conditions for dispensing from pharmacies
According to the recipe.Manufacturer
All information is presented for informational purposes and is not a reason for independent prescription or replacement of medication.
Zambon Switzerland Ltd.,
Via Industry 13, CH-6814 Cadempino, Switzerland.
Monural is a drug that is widely used for bacterial inflammatory processes of the urinary system. It differs from many other medications in its high efficiency, which allows it to be prescribed in situations where other drugs have not had the necessary effect. Monural analogues are also often used in urological practice.
Characteristics of the drug
The active ingredient in Monural is fosfomycin. The medication is a natural antibiotic. Its mechanism of action is the ability to inhibit several enzymes that play a very important role in the metabolism of bacterial cells.
This leads to the inability of further reproduction of pathogenic microorganisms, which causes their lysis and death. It also increases the sensitivity of bacteria to the protective mechanisms of the patient's immune system.
Monural is used for oral administration. In numerous experiments, it showed a bioavailability rate above 60% - about two-thirds of the taken dose of the drug is absorbed in the digestive tract and enters the systemic bloodstream. This antibiotic is not metabolized in the body and is excreted by the kidneys in unchanged form. This feature determines the range of application of the drug.
Most strains of staphylococci, Escherichia coli, enterobacteroides, Klebsiella, and Proteus are sensitive to fosfomycin.
It is these microbes that cause most of the inflammatory processes in the urinary system. Monural is prescribed for cystitis, urethritis, prostatitis, adnexitis, parametritis, bartholinitis, for the prevention of bacterial complications after manipulations and operations on the pelvic organs. You can also use the drug for bronchitis, bronchiectasis, pleurisy, lung abscesses, and some peritonitis.
Contraindications include the presence of serious damage to the renal filtration function, which can lead to the accumulation of the antibiotic in the blood. Sometimes this causes an overdose. Monural should also not be prescribed if the patient has had hypersensitivity reactions to the drug in the past.
The most common side effects when using this antibacterial agent are: 
- development of dyspeptic symptoms and digestive disorders (nausea, vomiting, diarrhea, flatulence, lack of appetite);
- allergic reactions of varying severity (skin rash, anaphylactic shock, Quincke's edema);
- symptoms of damage to the central nervous system (headache, the presence of systemic dizziness, tinnitus, visual impairment, increased drowsiness, provocation of migraine, anxiety, parasthesia);
- signs of cardiovascular system disorders (palpitations, tachycardia, chest discomfort);
- disorders of hematopoietic processes.
Monural's analogs
This antibacterial drug is a domestic analogue of Monural. These drugs have one active agent - fosfomycin. Urophosphabol differs from Monural, first of all, in its more affordable price. In fact, it is a generic with its own disadvantages and advantages.
For Urophosphabol, there is less evidence for comparative effectiveness in inflammatory bacterial processes of the excretory system. This is due to slightly different pharmacological production methods, as well as other additional components of the drug.
The relatively low price of Urophosphabol allows it to be more widely used in urological and surgical practice. The drug is produced in the form of a powder for the preparation of injections for intravenous administration. Urophosphabol is mainly used in hospital settings.
Urophosphabol is usually used 2-4 g 3-4 times a day. Usually the course of treatment lasts at least 5 days.
Nitroxoline Forte
Nitroxoline Forte consists of the substance of the same name. It is classified as an antibacterial drug that is used primarily in urological practice. The drug is often called one of the first uroseptics.
Nitroxoline has the ability to inhibit DNA synthesis by pathogenic microbes, which makes them unable to reproduce and die. Mainly shows bacteriostatic effect. The drug acts on E. coli, uroplasma, mycoplasma, Proteus and staphylococci, as well as some strains of fungi (mainly candida).
Nitroxoline is well absorbed from the digestive tract and metabolized in the liver. The drug is also capable of potentiating the effect of other antibiotics (tetracyclines) and fungicidal agents. Nitroxoline is very often prescribed for cystitis and urethritis.
Contraindications to Nitroxoline include primarily hepatic or renal functional failure against the background of organic pathologies. Also, this antibacterial drug should not be used if you have hypersensitivity to it.
Nitroxoline is produced in the form of tablets of 50 mg. It is usually prescribed 100 mg 4-5 times a day, due to its rapid elimination from the body.
It is also necessary to take into account the decrease in the effectiveness of the drug due to the development of antibiotic resistance to Nitroxoline.
This phenomenon is due to the widespread use of the drug in the past.
Levofloxacin is a classic fluoroquinolone drug. It has a wide spectrum of action against many bacterial pathogens. Levofloxacin has a bactericidal effect, which is caused by blocking DNA gyrase. This leads to the destruction of cells of pathogenic microorganisms, their death and lysis.
Levofloxacin is classified as a systemic antibiotic. This means that it is able to accumulate in therapeutic concentrations in many tissues of the body. This antibiotic is used for pathologies caused by staphylococci, pneumococci, streptococci, E. coli, enterococci, Klebsiella, mycoplasma, enterobacter, clostridia, legionella and other bacterial pathogens.
The drug is available in the form of tablets and vials for intravenous administration. Most of levofloxacin is excreted unchanged by the patient's kidneys, which facilitates the use of the antibiotic in urological practice. It is prescribed for cystitis, urethritis, prostatitis, pyelonephritis and other pathologies of the urinary tract.
It is prescribed mainly in situations where initial therapy has been ineffective, or the patient has contraindications to first-line antibiotics.
This drug, when used quite often, can cause a number of complications. The most common disorders are the patient's digestive system.
Particularly dangerous is pseudomembranous colitis, which sometimes leads to sepsis and intestinal perforation. A toxic effect on the liver has also been described, which is manifested by an increase in the concentration of enzymes of this organ in the patient’s blood.
Levofloxacin should not be used in early childhood, during lactation and in pregnant women.
Quite often, a Latvian-made drug, Furamag, is used in outpatient or inpatient practice. This medicine consists of furagin, a substance from the nitrofuran series. Additionally, it contains magnesium carbonate, which changes the pharmacological properties of the main active ingredient.
Thanks to it, furagin molecules are not broken down, and its bioavailability increases three times.
The drug is practically not metabolized. In the blood and peripheral tissues of the body (with the exception of lymphatic) its concentration remains low. But furagin is quickly excreted in large quantities by the kidneys, which allows it to be used for the complex treatment of bacterial pathologies of the urinary tract. Furamag showed good effectiveness against staphylococci, enterobacter, proteus, cytobacter and other pathogens.
The drug is released in the form of capsules of 50 mg. Usually it must be taken before meals, 1-2 capsules (50-100 mg) 2-3 times a day, with a sufficient amount of water. The course of treatment usually lasts at least 7 days.
Side effects that may occur when using Furamag usually include digestive tract disorders, toxic effects on the liver (cases of toxic hepatitis have been described) and the central nervous system (dizziness, headaches, tinnitus).
Another synthetic antibacterial drug that is used as an analogue of Monural is Furadonin. Its active ingredient is nitrofurantoin. This drug belongs to the nitrofuran group. Furadonin in experiments showed a predominantly bacteriostatic effect, which it realizes by inhibiting the synthesis of RNA and protein in the cells of pathogenic microorganisms.
The drug is well absorbed when administered orally in the digestive system. Furadonin is completely excreted from the body by the kidneys and is a classic uroseptic, since the range of its use is limited precisely by the pathologies of one system.
Nitrofurantoin effectively acts on staphylococcal, streptococcal, enterobacter microflora.
The drug is available in the form of tablets of 50 or 100 mg. The duration of therapy is usually from 5 to 14 days. An adult should take 1 tablet of the appropriate dose 3-4 times per day. Take with food to reduce possible side effects.
Furadonin should not be prescribed in the following situations: 
- if you have had allergic reactions to nitrofurans in the past;
- with significant impairment of renal function;
- during lactation;
- during pregnancy;
- patients with allergic pathologies during exacerbation;
- patients with congenital or acquired deficiency of glucose-6-dephosphate hydradenase.
Among the side effects, the most common are transient disorders of the digestive tract (diarrhea, constipation, nausea, flatulence), which quickly disappear after discontinuation of the drug. The development of allergic reactions of varying severity was also noted. In some patients, exacerbation of systemic inflammatory diseases (lupus, vasculitis) was observed while taking the drug. Cases of cough, chest pain, suppression of hematopoiesis, hair loss and broncho-obstructive syndrome have been described.
The most commonly used fluoroquinolone antibiotic for the treatment of bacterial pathologies of the excretory system in an outpatient setting is Nolitsin. Its active ingredient, norfloxacin, belongs to the second generation of drugs in this group. As a typical representative of forquinolones, Nolitsin has a pronounced bactericidal effect. The drug molecules have the ability to disrupt DNA synthesis in microbial cells, which leads to their death.
Nolitsin is quickly absorbed in the lumen of the digestive tract. Its bioavailability is about 40 percent. In the body, the drug is partially metabolized in the liver, and the rest is excreted by the kidneys. Therapeutic concentration lasts up to 8 hours.
The drug is effective against a wide range of pathogens - streptococci, staphylococci, E. coli and many others.
Nolicin is primarily prescribed for urogenital infections in women and men, both nonspecific (urethritis, cystitis, prostatitis) and specific (gonorrhea).
It should be used with caution in case of impaired liver or kidney function. In such patients, careful monitoring of antibiotic concentrations in the blood is necessary to minimize the risk of developing overdose symptoms.
The drug is available in the form of tablets of 400 mg of norfloxacin. The usual treatment regimen looks like this: the antibiotic should be taken twice a day (morning and evening), 1 tablet. The duration of treatment is individual and depends on the severity of the disease, but almost always is at least three days.
Among the contraindications to prescribing the drug, it is necessary to highlight the presence of hypersensitivity to norfloxacin, the period of pregnancy and lactation in a woman, and the patient’s age under 12 years.
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Monural, as a drug of great bactericidal effect, actively fights the causative agents of many diseases. The active substance fosfomycin has a pronounced antibacterial effect. Available form: granules for preparing a solution.
Area of application of the drug: treatment of acute bacterial cystitis, nonspecific urethritis, massive bacteruria, prevention of postoperative rehabilitation. Restrictions for use: allergic rashes, kidney dysfunction, children under 5 years old. Average prices are 520–550 rubles.
Russian-made analogues
Domestic manufacturers provide cheap analogues of the drug, which makes it easy to select the right medication. The main prototypes are defined in the following table.
| Prototype | Price in rubles | Description |
| Bacteriophage Coli | 690–700 | A quality synonym for monural. It looks like a yellow solution. The area of application is the therapy of bacterial pathologies of various forms. High sensitivity to the main composition is a contraindication. |
| Calcex | 35–50 | The cheapest analogue of monural presented by a Russian manufacturer. Tablets of a special form. Used as a prophylaxis for infectious pathologies. |
| Nitroxoline | 60–100 | A cheap substitute for monural is produced in the form of white tablets. The active compound nitroxoline provides a bactericidal effect. Actively prescribed for cystitis of various forms and other pathologies of the genitourinary system. Prohibited during pregnancy, lactation feeding, cataract development, lack of liver and kidney function. |
| Phosphocin | 200–220 | Inexpensive prototype of the original. It has the form of soluble granules for making a solution. The composition of the medicine is based on the content of the active compound and ensures its effectiveness. Intended for the treatment of uncomplicated pathologies of the genitourinary system. Contraindications: hemodialysis, allergic rashes, age limit up to 12 years. |
| Urophosphabol | 100–170 | A worthy replacement for a cheap analogue of Monural. Powder for preparing a green solution. Effective in the systemic treatment of antimicrobial diseases. |
Ukrainian substitutes
Representatives of the Ukrainian medical industry have inexpensive and high-quality analogues of monural in various forms of release.
Detailed consideration in the following list:
- Dioxidine. One of the inexpensive analogues of the original made in Ukraine. Presented in powder form for preparing a solution. The active substance ensures the antimicrobial nature of the origin of the drug.
Indications for use: purulent infectious pathologies of various etiologies. Not recommended for severe sensitivity. Average prices are 300–320 rubles.
- Dioxysol. Synonym for cheaper monural. It is produced in the form of a solution and is used in the treatment of antibacterial diseases.
It has a number of contraindications: bradycardia, arterial hypertension, cardiogenic shock, allergies to the main components, insufficiency of the adrenal cortex. Average prices are 110–115 rubles.
- Uroxoline. The cheapest prototype. Tablets of a special form. Antimicrobial agent for systemic treatment. Used for uncomplicated genitourinary flows.
The drug is prohibited for disorders of the liver, kidneys, allergies. Average prices are 10–30 rubles.
- Urofoscin. An effective antibacterial drug. Fosfomycin destroys pathogens during the development of pathological infectious diseases of various types.
It is necessary to exclude use for hemodialysis, liver dysfunction, kidney dysfunction, allergies, and children under 12 years of age. Average prices are 200–250 rubles.
- Cystoral. Inexpensive prototype presented as granules for internal use. The active compound is a natural antimicrobial agent.
Effective in acute cases of mild genitourinary infections. High sensitivity, typical allergic rashes, hemodialysis, children under 12 years of age are contraindications for use. Average prices are 350–400 rubles.
Belarusian generics
Belarusian-made drugs do not provide analogues that have the same structure of the drug, but among them you can select several medications with a similar effect.
Table of close generics:
| Prototype | Price in rubles | Description |
| Doxycycline | 500–600 | Antibiotic drug. Relative analogue of monural. Scope of application: various infectious manifestations. Contraindications: carrying a child, lactation feeding, lack of liver and kidney function, age category up to 8 years. |
| Cephalexin | 300–380 | Cheap analogue of Belarusian production. Solution for injections. Indications for use: treatment of infectious pathologies of various etiologies. |
| Cystivitis | 200–220 | An analogue of Monural is cheaper. Effective in acute infectious and inflammatory processes of the genitourinary system. You should not take the medicine during pregnancy, lactation, allergic processes, age restrictions up to 12 years. |
Foreign analogues
A modern range of imported drugs with a similar effect to monural has a large number of positive qualities and a relatively low cost.
List of the most famous substitutes for the original:
- Kirin. A synonym for monural, produced as a tricyclic antibiotic. The active compound spectinomycin has a pronounced antibacterial effect and is prescribed for the treatment of infections of the genitourinary system.
- Lizomac 600. The best analogue of Monural, produced by imported pharmacists. Presented in the form of film-coated tablets. Used in the treatment and prevention of bacterial infections of various forms.
Contraindications: hypersensitivity, arterial hypertension, thyrotoxicosis, exacerbation of schizophrenia. Average prices are 1300–1400 rubles.
- 5-knock. A close prototype of the original, produced in the form of tablets. Nitroxoline guarantees the bactericidal properties of the drug. Effective in the acute course of pathological infections of the genitourinary system.
The medicine should not be used if you are pregnant, lactating, or have kidney or liver failure. Average prices are 250–270 rubles.
- Fosmural. An effective antimicrobial drug for the systemic treatment of genitourinary infections.
The composition of the drug is based on the action of the fosfomycin component, which has an antibacterial effect.
High sensitivity to the active compound is an exception to use. Average prices are 400–450 rubles.
Summing up involves a description of all the characterizing qualities of the drug, showing its effectiveness. The medicine has a sufficient number of worthy and inexpensive analogues.
Before deciding what to replace Monural with, you should consult a qualified doctor, which will bring a positive effect from the use of the medication!
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There are restrictions during pregnancy
Has restrictions when breastfeeding
Has restrictions for children
Has restrictions for older people
Has limitations for liver problems
Has limitations for kidney problems
Monural is an antibacterial drug used in urology in the treatment of cystitis and other acute or chronic pathologies of the urinary system. It is also prescribed for prophylactic purposes to patients undergoing surgery. It is recommended to take on an empty stomach after emptying the bladder, at two-hour intervals before and after meals. One packet is diluted in 70-100 g of water. Can be taken once or in a short course depending on the condition and age.
Contraindications to the prescription of the drug are individual intolerance to its components, age under 5 years, severe renal failure. It is strictly unacceptable for patients undergoing hemodialysis to take Monural. Admission is possible during pregnancy, but only as prescribed by a doctor and under his supervision. When using the medicine during lactation, it is recommended to stop breastfeeding.
Despite the fact that Monural cannot be called too expensive, many patients are looking for cheaper analogues of this product and they are no less effective.
Contains the active substance fosfomycin in a dose of 3 g. Sold in the form of a sachet with powder for the preparation of an oral suspension. Self-medication is not recommended, but it is necessary to know what can replace the medication in question. A replacement may be required not only due to inappropriate cost, but also in the event of individual intolerance to any component or the absence of the original medication in the pharmacy.
There are several analogues of Monural with the same composition, but cheaper. The price for these, as well as other substitutes for this medication in Russia is shown in the table.
Cheaper analogues in composition
Cheaper structural substitutes used for cystitis are the antibiotics Urophosphabol, Ecomural and Phosforal Rompharm.
Urophosphabol
Urophosphabol is an antimicrobial drug containing the active substance fosfomycin. Dispensed in powder form for the preparation of a solution for intravenous injection. 1 ampoule may contain 1 or 4 mg of fosfomycin.
The drug is intended for the treatment of:
- infectious diseases of soft tissues;
- infectious lesions of joints and bones;
- bacterial pathologies of the respiratory system;
- acute cholecystitis;
- cholangitis;
- peritonitis;
- salpingitis;
- endometritis;
- pelvioperitonitis;
- infectious pathologies of the urinary system: cystitis, nephritis, pyelonephritis, etc.
Also, the use of Urophosphabol is advisable for sepsis, bacterial meningitis or endocarditis. However, in these cases, the medication is not used as an independent remedy, but in combination with antibiotics from other groups.
The drug is contraindicated in persons with hypersensitivity to fosfomycin or other components of the composition. It is also not recommended for use in patients with renal or heart failure, arterial hypertension, or a history of allergies to medications. Urophosphabol is prescribed with extreme caution to elderly patients.
Before use, the powder is diluted with water for injection in a proportion of 10 ml per 1 g. The liquid is introduced into the bottle, after which it is shaken well. It is important that there is not a single lump.
The average dosage of the drug for adult patients is 2-4 g. The solution is administered intravenously every 6-8 hours.
Important! For the treatment of patients with renal failure, another titration of the dose of Urophosphabol is carried out. It directly depends on the glomerular filtration rate, therefore patients with chronic renal failure are recommended to undergo therapy with Urophosphabol in a hospital setting.
Children from the neonatal period are administered 200-400 mg of the drug per kg of body weight. The daily dosage of the medicine is divided into 3 administrations. The interval between manipulations should be at least 8 hours. The duration of therapy is determined individually for each patient.
Urophosphabol has many side effects, but they rarely occur in patients. Negative reactions include:
- rash on the body;
- headache;
- dizziness;
- increased fatigue;
- pain at the injection site;
- hypokalemia.
As a rule, the occurrence of side effects is associated with rapid administration of the medication. But their occurrence does not always require discontinuation of the drug. The main differences between Urophosphabol and Monural are the price, release form, method of application, and the possibility of treating newborns.
Ecomural
Ecofomural is an antibiotic containing fosfomycin. Dispensed in the form of granules, soluble in water and intended for the preparation of an oral solution. Taking Ecofomural is indicated for bacterial diseases of the urinary system of varying etiology and severity:
- asymptomatic bacteriuria;
- cystitis;
- pyelonephritis;
- jade, etc.
The drug is also prescribed for prophylactic purposes - to prevent the development of infectious pathologies after surgical interventions or transurethral diagnostic procedures.
Contraindications to the use of Ecofomural are individual intolerance, severe renal failure, glucose-galactose malabsorption, sucrase/isomaltase deficiency, children under 5 years of age.
An antibiotic can lead to:
Ecomural is not intended for long-term use. As a rule, it is taken once, on an empty stomach, about 2-3 hours before or after meals. It is recommended to empty your bladder before taking the medicine.
The dosage of the medication is calculated as follows:
- Adult patients and adolescents over 12 years of age: 3 g/day once.
- Children 5-12 years old: 2 g/day.
Before use, the contents of the sachet must be dissolved in half a glass of water. The course of therapy lasts only 1 day.
Note. For preventive purposes after surgical interventions or invasive diagnostic procedures, the prescribed dose is taken 2 times a day. The solution is prescribed 3 hours before the operation, then a day after it.
Ecomural is a direct analogue of Monural and has the same composition and release form. Only the prices of the drugs are different.
Phosphoral Rompharm
Phosphoral Rompharm is a powder for the preparation of an oral solution. This is another structural substitute for the drug Monural. The medicine is intended for the treatment of uncomplicated bacterial pathologies of the lower urinary tract.
The drug is not prescribed to patients if there is an individual intolerance to its components. It is contraindicated during pregnancy and breastfeeding, with severe renal failure and during hemodialysis.
The most common side effects caused by taking medications include:
In extremely rare cases, anaphylactic shock or angioedema may develop. The medicine is taken orally on an empty stomach. Usually, 1 dose of medication in a dose of 3 g is enough for adults and children over 12 years of age. Before use, dissolve the contents of the sachet in half or a quarter glass of water. Mix well and consume immediately.
If Phosphoral is used for preventive purposes - during surgical operations or invasive diagnostic procedures - then its dose is doubled. In this case, the first sachet should be taken before the scheduled procedure, the second - a day after it. When treating more severe diseases, they also resort to prescribing a double dosage of the drug. The interval between doses should be 24 hours. Phosforal Rompharm differs from Monural only in its cost: it is more affordable.
Inexpensive substitutes for the treatment of cystitis
Drugs that correspond to Monural in the mechanism of action, but differ in composition, are Furadonin, Amoxicillin and Urolesan.
Furadonin is a tablet preparation containing the active substance nitrofurantoin. This element is considered a highly effective uroantiseptic, which at the same time has a pronounced antibacterial effect.
The use of the drug is advisable when:
- pyelonephritis;
- cystitis;
- pyelite;
- urethritis.
Furadonin is used not only for therapeutic, but also for preventive purposes. In particular, to prevent relapses of the above pathologies. It is also prescribed to patients before and after surgery, during catheterization or invasive transurethral diagnostic procedures.
The antibiotic is contraindicated for pregnant and lactating women, children under 3 years of age, as well as patients with:
The drug is taken immediately after meals with plenty of liquid. For acute infections, patients over 12 are prescribed 100 mg of the drug twice a day; for children, the dose is calculated separately. The duration of therapy is 7 days. When treating severe chronic recurrent infections, 100 mg of the drug is prescribed four times a day.
The duration of the therapeutic course is 1 week. For adults, the maximum permissible single dosage is 300 mg of the drug. It is allowed to take no more than 600 mg of Furadonin per day.
Common side effects include:
Much less often, patients develop anaphylactic shock and angioedema. Furadonin has many differences from the main medicine. First of all, this is the composition and pharmacological group.
Amoxicillin
Amoxicillin is a semi-synthetic antibiotic, available in the form of capsules and granules for the preparation of an oral suspension. The drug belongs to the penicillin series and has a wide range of therapeutic effects. The use of Amoxicillin is advisable not only for damage to the urinary system; it is also prescribed for the following pathologies of bacterial etiology:
It is also possible to take Amoxicillin for bacterial lesions of bone tissue. Contraindications include:
- hypersensitivity to drug components;
- allergy to penicillin antibacterial agents;
- infectious mononucleosis;
- lymphocytic leukemia;
- ARVI.
Before using the granules, it is necessary to prepare a suspension. To do this, you need to boil water, cool it, and then add it to a jar of powder. There is a special 100 ml mark on it, indicating the required amount of water. After this, the bottle must be shaken well to form a homogeneous suspension.
The dosage regimen is set individually, but usually it corresponds to the instructions below.
In case of severe disease, the dose of medication for adults is increased to 1000 mg (4 scoops) 3 times a day. The duration of therapy is determined individually. As a rule, it is 5-14 days.
Among the possible negative consequences of taking Amoxicillin are skin manifestations of allergies. Sometimes patients complain of dyspeptic disorders, manifested by nausea, vomiting, and epigastric pain. The differences between Amoxicillin and Monural are: cost, release form, rules of administration and indications for use.
Urolesan
Urolesan is a combination preparation made on a natural, plant basis. It has anti-inflammatory, diuretic, bactericidal effects and is widely used for the treatment and prevention of urological diseases:
Urolesan oral drops should not be prescribed to patients with stomach diseases or those with individual intolerance to their components. The medicine is also contraindicated in patients with a history of seizures of any nature and etiology. The drug is approved for use from 18 years of age. Due to lack of research, use is not recommended during pregnancy and lactation. It is dangerous to take the drug in cases where the diameter of kidney stones is more than 3 mm.
Drops must be taken before meals. Adult patients are recommended to drink 8-10 drops three times a day. With the development of renal or hepatic colic, the dosage can be increased to 15-20 drops. The medicine has a specific taste, so it is recommended to drip it onto a piece of sugar. It can also be taken with a small amount of water.
Important! Despite the instructions from the manufacturer, the single dosage and duration of the therapeutic course are determined by the doctor individually for each patient.
Urolesan is usually very well tolerated by patients. Occasionally, allergic reactions, including skin reactions, stomach pain, dyspepsia, muscle hypotonicity, and limb tremors are possible. A herbal medicine is fundamentally different from the main medicine - both in composition, indications, release form, price and many indications.
