Instructions for using the drug Papaverine for treatment contains information on each of its dosage forms. Also, descriptions of the pharmacology and pharmacokinetics of Papaverine, a detailed dosing regimen and indications for administration are given. In addition, there is information for various categories of patients and warnings about side effects.

Pharmacology

Being a myotropic antispasmodic, the drug inhibits phosphodiesterase, promotes the accumulation of intracellular hormone cAMP in cells and a decrease in intracellular calcium content in them. Also, due to its effect, there is a decrease in the tone of the smooth muscles of the vessels and organs of the gastrointestinal tract, as well as those that are part of the respiratory, urinary and reproductive systems. Arteries dilate, blood flow increases. Papaverine is also capable of exerting a hypotensive effect.

High doses of the drug help to reduce the excitability of the heart muscle and slow down the conduction of the intracardiac. In the recommended doses, Papaverine has practically no effect on the central nervous system or it is mild.

Pharmacokinetics

The drug has good distribution in the body, penetrating through histohematic barriers. With plasma proteins, the binding is almost complete - 90%. The bioavailability index is 54%. Metabolism takes place in the liver. The half-life is from half an hour to two hours. In some cases, its increase reaches 24 hours.

Papaverine is excreted by the kidneys as metabolites. To completely remove it from the blood, you can resort to dialysis.

Papaverine indications for use

Papaverine is prescribed as an aid in preparing the patient for surgery. In addition, it is used for angina pectoris, which is part of the combined treatment.

Contraindications

The appointment of the drug should not be carried out for those patients who suffer from hypersensitivity to the drug, as well as the elderly and babies up to six months. In addition, a contraindication to taking Papaverine is the presence of severe renal failure, glaucoma and atrioventricular blockade.

Papaverine instructions for use

Papaverine injections

Papaverine injections can be administered both intramuscularly and intravenously.

A single dosage should not exceed:

Adults over 20 milligrams;

Elderly no more than 10 milligrams;

Children from one to 12 years of age no more than 300 micrograms per kilogram of body weight.

There should be at least four hours between injections.

Papaverine tablets

Papaverine tablets are taken orally.

Papaverine candles

Candles Papaverine is used for rectal administration.

Papaverine for the elderly

The use of Papaverine by elderly patients is undesirable due to the fact that they have a high risk of developing hyperthermia.

Papaverine during pregnancy

There are no established data either on the safety of the drug for pregnant women or on its effectiveness.

Papaverine for children

The appointment of Papaverine for children under six months is prohibited.

Side effects

Patients complained of nausea and constipation. Drowsiness, excessive sweating and hypotension have also been reported. It was observed that the activity of hepatic transaminases increased.

The rapid introduction of the drug in the form of injections, as well as the intake of high doses of it is fraught with cardiac arrhythmias and the development of atrioventricular blockade.

Drug Interactions

The combined use of Papaverine with other medicines can lead to the following:

Anticholinergics - their effect is enhanced;

Levodopa - a decrease in its effectiveness;

Methyldopa - a decrease in the hypotensive effect.

Additional instructions

The drug requires careful use in the following cases:

• conditions after the patient has suffered a traumatic brain injury;
• chronic form of renal failure;
• lack of functionality of the adrenal glands;
• hypothyroidism;
• hyperplasia of the prostate gland;
• supraventricular tachycardia;
• shock states.

Intravenous infusion should be carried out slowly, under the supervision of a doctor.

Treatment with Papaverine excludes the use of alcoholic beverages.

Papaverine analogues

The drug has analogues of each of its dosage forms.

• Tablets: Papaverine Hydrochloride MS, Papaverine Hydrochloride.
• Candles: Papaverine Hydrochloride.
• Solution: Papaverine Hydrochloride, Papaverine Bufus.

Papaverine price

The cost of the drug Papaverine in any of its types is small. Prices in different pharmacies may vary, but nowhere the drug costs more than 100 rubles.

The drug has a slight hypotensive, analgesic effect, is prescribed for adults and children.

The composition of the drug

Papaverine tablets contain a medicinal substance such as papaverine hydrochloride. Each tablet contains 10 mg of the active ingredient and excipients (stearic acid, talc, sugar, potato starch).

Release form

Tablets are one of the forms of release of Papaverine. In addition, the drug is produced in the form of rectal suppositories and ampoules with a solution for injection. Candles and injections have the same effect as an oral remedy. Tablets are produced in 10 pieces in one blister placed in a cardboard box. Each package contains instructions for the use of Papaverine tablets, from which you can find out detailed information about the medication.

pharmachologic effect

Consider what Papaverine tablets are used for and what effect the drug has on the body. For adults and children, the medicine is prescribed to eliminate spasms and pain in various conditions. In addition, the drug has a slight vasodilating effect, due to which it can lower blood pressure.

Tablets help relieve spasm of the smooth muscles of the uterus, stomach, intestines, gallbladder, bronchi, larynx, kidneys, bladder, blood vessels and some other organs.

After the penetration of the active component into the blood, the activity of the phosphodiesterase enzyme is inhibited, which leads to a decrease in the amount of calcium in the human body, as a result of which the ability of smooth muscles to contract decreases and this process slows down.

Indications

The drug should be taken only with the permission of a doctor. Self-treatment with this tool is strictly prohibited, as it has some contraindications. Papaverine tablets are recommended for the treatment of the following conditions:

• renal colic;
• inflammatory process of the gallbladder, accompanied by spasm and pain;
• spastic colitis;
• hepatic colic;
• to relieve the tone of the uterus;
• in the complex therapy of bronchospasm;
• treatment of angina pectoris, recovery after a heart attack, stroke.

Papaverine eliminates spasm, has a mild analgesic effect

More often, Papaverine is prescribed as a complex therapy; for self-treatment, the drug is used less frequently, since it only relieves the symptoms of a particular pathology.

Contraindications

Papaverine should be used in strict accordance with the instructions for use or according to the scheme prescribed by the doctor. Violation of the method of administration and dose of the drug can cause severe complications and side effects.

• the age of the child up to six months;
• elderly age. Among patients who have reached the age of 65, the remedy is recommended to be used under the strict supervision of a specialist;
• persistent hypotension;
• the presence of an allergic reaction to the active ingredient of the drug or its excipients;
• precoma or coma;
• violation of atrioventricular conduction;
• glaucoma.

Dosage and methods of administration

Papaverine should be taken according to the scheme selected by the doctor based on the patient's diagnosis. The tablets are intended for oral administration. It is recommended to drink the medicine with water. The standard regimen for adults is 3 tablets throughout the day. For children, the dosage is 1-2 tablets, depending on weight, age and other individual characteristics. The duration of therapy is selected for each patient separately.

The dose and regimen of the drug are selected by the doctor

Use by pregnant women

How to take the drug for women in position? Papaverine during pregnancy is prescribed to patients by a leading doctor in the presence of indications such as increased uterine tone, high blood pressure and some other conditions accompanied by spasm of smooth muscles. The dose of the drug is selected individually, usually 3 tablets per day. The duration of treatment depends on the symptoms and the therapeutic effect. In late pregnancy, the drug is used to lower pressure with uncomplicated preeclampsia.

Papaverine in pediatrics

From what and in what dosage is the remedy prescribed to small patients? Papaverine is prescribed for children from the age of six months, if there are medical indications for this. Patients under 4 years of age are usually prescribed half a tablet 1-2 times a day. From 4 to 6 years - 1 tablet, from 6 to 9 - 1.5-2 tablets. The duration of treatment for children is selected by the doctor depending on the diagnosis and clinical picture of the patient.

Side effects

Papaverine has mostly positive reviews. Side effects are extremely rare. The reason for the negative consequences is a violation of the dosage and regimen of medication.

The main side effects while taking the medication:

• nausea;
• rarely vomiting;
• a strong decrease in pressure;
• rashes on the body of an allergic nature;
• eosinophilia;
• increased sweating;
• dyspeptic disorders;
• heart block.

Side effects include headache, nausea, and other symptoms

Taking too much of the drug can cause heart failure, drowsiness, double vision. If these symptoms appear, the patient should be immediately taken to a hospital where gastric lavage and other medical measures are performed.

Analogues

Analogues of Papaverine, similar in their indications and scope, are as follows:

• Riabal - is indicated for patients with diseases of the digestive system, accompanied by pain and spasm of smooth muscles. The drug is widely used for diseases of the urinary system;
• Dibazol is an antispasmodic drug that has a mild analgesic, vasodilating, hypotensive effect. Among the indications for the use of drugs, there are pathologies that cause spasms of blood vessels, exacerbation of hypertension, digestive diseases accompanied by spasm, and other conditions. The drug is produced in the form of tablets and solution for intravenous administration;
• Platifillin is a drug that has a sedative, antispasmodic, analgesic effect on the body. The medicine is used for stomach cramps, gastritis, ulcers, acute and chronic pancreatitis, cholecystitis, bronchospasm, as well as to lower blood pressure in hypertension and other diseases of the cardiovascular system;
• No-Shpa is a widely used drug used as an additional therapy for many pathologies. No-Shpa is prescribed to eliminate spasms of internal organs and blood vessels. The medicine helps to relieve pain in the pathologies of the gastrointestinal tract, diseases of the respiratory system, heart and blood vessels, diseases of the genitourinary system and other organs;
• GastroComfort is a herbal medicine that includes cumin, dill, fennel and other components. The drug is prescribed to patients with diseases of the digestive system. Among the main indications are pain, spasms of the stomach and intestines, flatulence and other manifestations.

Dibazol - one of the analogues of Papaverine

Important! Each of the analogues has its own contraindications, so they can only be used with the permission of a doctor.

drug interaction

In combination with other medications, the effect of Papaverine may increase or, conversely, decrease.

Enhance the effect of the drug:

Before using Papaverine, you should inform your doctor about any drugs that are taken by the patient or were taken the day before.

The drug Papaverine is prescribed exclusively by a doctor. The specialist selects the dose and regimen of medication. The course of therapy usually lasts from 7 to 14 days until the pain is completely eliminated.

With special care give medicine to children. If the child has not learned to swallow the tablet, it is recommended to crush it into powder, mix it with a little water, and give it to the baby.

It is strictly forbidden to combine Papaverine with alcoholic beverages

In acute pain syndrome caused by severe diseases of the gastrointestinal tract, respiratory organs and cardiovascular system, Papaverine tablets should be replaced with injections.

The tool does not affect the concentration of attention and memory, therefore, it can be prescribed to patients with various professional activities.

Terms of sale and price of funds

From the pharmacy, the drug is dispensed by prescription, as it refers to myotropic antispasmodics. It is recommended to store the medicine at room temperature in protected places from children. The approximate cost of Papaverine in tablets is from 25 to 35 rubles.

Patient reviews

Veronica, Volgograd

“I suffer from a peptic ulcer, which is constantly getting worse. In combination with other drugs, I take Papaverine tablets during the period of severe pain. The product is cheap but very good. Within 15 minutes after use, the condition is relieved. For several years of admission, there were no negative consequences. I consider this medicine to be the best antispasmodic in terms of price and quality.

Valeria, Izhevsk

“I was diagnosed with hypertension at a fairly young age. I often experience headaches, weakness, apathy and other unpleasant symptoms. The attending physician prescribed me Papaverine as an adjuvant. Since then, I always carry the pills with me. The drug helps to cope with pressure, relieves pain. The price of the medicine and its effect suit me quite well.

Elizabeth, Minsk

“I take Papaverine for abdominal pain. I do not trust imported expensive products, because I believe that they are made on the basis of the same active ingredients, but are much more expensive. Papaverine quickly eliminates spasm, alleviates the condition. I recommend this product to everyone."

Maxim, Cheboksary

“Several years ago I was diagnosed with urolithiasis. Since then, the pebbles periodically come out on their own, as they are small in size. Papaverine helps me with pain during this period. The process of exiting the stone becomes less painful. In fairness, I want to say that I would not advise self-medication, because renal colic can happen. It is best to carry out treatment under the supervision of a physician.

“This drug was prescribed to my father during the recovery period after a heart attack to normalize blood pressure. The tool is cheap but works great. At least we didn't have any problems with it. There were no side effects or complications."

Papaverine instructions for use, composition, indications, analogues and reviews

The drug Papaverine is a drug whose main active ingredient is papaverine hydrochloride. This active substance has an effect on smooth muscle elements, causes them to relax, so the drug belongs to the group of myotropic antispasmodics.

Composition and form of release

Release form of the drug:

• Tablets.
• Suppositories are rectal.

The drug is available in tablets of 10 mg and 40 mg, packaged in blister blisters of 10 pieces. Tablets are white, bitter taste, do not have any odor.

Also common is a solution of Papaverine for injection, produced in ampoules of 2 ml. The drug carton contains 10 pieces. You can also find papaverine suppositories or rectal suppositories, which are designed to be inserted into the rectum. The mass of each candle is 20 mg.

Papaverine - instructions for use in various dosage forms

Papaverine: use in the form of tablets

Instructions for the use of Papaverine provides for the possibility of using the drug by adults and children in various dosages. The dose of the oral form of the drug will depend on the person's age. The following treatment regimen is used:

• From 0.5 to 2 years - a dose of 0.005 g;
• From 3 to 4 years - 0.005-0.01 g;
• From 5 to 6 years - 0.01 g;
• From 7 to 9 years - use of 0.01-0.015 g;
• From 10 to 14 years old - 0.015-0.02 g;
• Over 14 years old - 0.04-0.08 g each.

How to use Papaverine and take it as a solution for injection

The active ingredient of the drug has a high bioavailability, so injections can be made intramuscularly and subcutaneously or intravenously. At the same time, the therapeutic abilities of Papaverine do not suffer, nor does it affect the final result. At the same time, subcutaneous injections of Papaverine should not be given to the distal part of the forearm, but rather to the outer surface of the thigh or shoulder, because the frequency of administration often leads to the appearance of a hematoma.

Intramuscular injections of Papaverine can be performed according to the traditional scheme using the upper lateral quadrant of the buttock. Before the implementation of intravenous injections, the amount of the drug prescribed by the doctor must be broken up in ml of isotonic sodium chloride solution. It must be recalled that Papaverine should be administered slowly so that during the injection process a person does not experience discomfort. The contents of one ampoule are usually injected subcutaneously.

The dosage of Papaverine solution for intramuscular and intravenous administration is as follows:

• For adults: 0.3 g daily and 0.1 g single;
• For children: up to 0.2 g daily and up to 0.06 g single (depending on age).

The use of papaverine for hemorrhoids

Papaverine suppositories are used to treat hemorrhoids. The hemorrhoid itself is directly related to inflammatory processes, thrombosis, pathological expansion of the vessels that encircle the lumen of the rectum. Candles can alleviate the condition and cure the disease.

According to the instructions, it is necessary to start the course of treatment with 0.02 g of the drug, increasing the dosage gradually to 0.04 g (but only in cases where a smaller amount of the drug does not give the desired therapeutic effect). The instructions for use note that it is undesirable to use more than 3 suppositories in one day, because this can lead to the development of adverse effects, or cause an overdose, because the medicinal components in the rectal zone are absorbed too well.

It is best to put Papaverine candles in the morning and in the evening, before going to bed. If necessary, an additional candle can be placed at lunchtime. It is also not recommended to put candles too often.

Indications, contraindications, side effects of Papaverine

Indications for the use of papaverine

Instruction Papaverine provides the following indications for the use of the drug:

• Spasm of smooth muscles (especially often with spastic colitis, cholecystitis, pylorospasm);
• Hypertensive crisis (with combined conservative treatment);
• Endarteritis;
• Renal colic;
• Spasm of the vascular peripheral bed;
• Decrease in the lumen of the vessels of the brain due to the contraction of the muscular layer of the arteries;
• Bronchospasm;
• angina;
• reduction of renal arterial inflow of vascular origin;
• Urinary retention due to spasms of the urinary tract;
• Hemorrhoids, large hemorrhoids.

Papaverine is also often used before surgical intervention associated with urological or proctological manipulations with the abdominal cavity. The drug allows you to relax smooth muscle elements.

Contraindications for the use of papaverine

The following contraindications to taking Papaverine can be distinguished:

• Individual intolerance to the components of the drug;
• Violation of intracardiac conduction (especially atrioventricular block);
• High sensitivity to the drug;
• Severe form of liver failure;
• Glaucoma;
• Older age (there are high risks of developing hypertension);
• Children's age (up to 0.5 years).

The following conditions act as additional restrictions on the use of Papaverine (the drug can be used with regular supervision of experienced doctors):

• The presence of a recent traumatic brain injury;
• Chronic renal failure;
• Hypothyroidism;
• shock conditions;
• Benign hyperplasia of the pancreas;
• Supraventricular tachycardia;
• Insufficiency of the functional capabilities of the adrenal glands.

From the side of the cardiovascular system, atrioventricular ventricular blockade may occur. Also often there is a decrease in blood pressure and tachycardia. In addition, according to the instructions, among the main side effects of Papaverine are nausea, constipation, bloating, an increase in the activity of hepatic transaminases, and a violation of the passage through the digestive tube. Allergic reactions, drowsiness, eosinophilia may also occur.

How long can papaverine be used

The duration of the course of treatment is usually short, because immediately after the cessation of symptoms and the elimination of painful conditions, the drug is completed. Instructions for use Papaverine states that the drug can be used for a long time, in accordance with the courses prescribed by the attending physician.

Papaverine: application for children

Papaverine in various forms (tablets, suppositories, injections) is actively used in pediatric practice in many countries of the world, starting from the age of 6 months.

The medicinal effect of the drug Papaverine

The mechanism of the therapeutic effect of the substance is to influence the messengers (secondary mediators) of the transmission of muscle excitation. Papaverine inhibits phosphodiesterase, due to which cycloadenosine monophosphate begins to accumulate in cells. There is also a decrease in the level of calcium ions. Smooth muscles in response to such biochemical changes begin to relax, which is accompanied by a decrease in their tone.

The active component of the drug is completely and quickly absorbed by various routes of administration of the drug into the body. When it enters the bloodstream, the substance begins to bind to plasma proteins, due to which it passes through the histohematic barriers with ease. Undergoes biotransformation in the liver. The half-life after taking the drug is from 30 to 120 minutes (the duration will depend on the additional components of the drug). It is excreted to a greater extent by the kidneys in the form of metabolic products.

Compatibility of Papaverine with No-shpa

No-Shpa with Papaverine, as with many of its analogues, interacts well. The drug will have a therapeutic effect on the smooth muscle elements of the human body. The combined use of Papaverine and No-Shpa is most often found in gynecological and obstetric hospitals with high uterine tone, a serious threat of miscarriage, or with too active labor activity ahead of time.

No-Shpa and Papaverine can be used in combination for any condition that is associated with severe pain. The use of No-Shpa is not allowed if there are certain contraindications.

Among the analogues of Papaverine, many different pharmaceutical forms of drugs can be distinguished. A similar antispasmodic effect can be provided by the famous drug Drotaverine Hydrochloride, which is more common in our country under the name No-Shpa. In general, any drugs that give antispasmodic and anti-inflammatory effects can be attributed to the analogues of this medicine.

The price of the drug in pharmacies

Check out the price of Papaverine in 2018 and cheap analogues >>> The cost of Papaverine in different pharmacies can vary significantly. This is due to the use of cheaper components in the drug, and the pricing policy of the pharmacy chain. But the important thing is that the difference in price between foreign and Russian counterparts remains virtually unchanged.

What is Papaverine and how does it work?

What is Papaverine? This is a drug known for a very long time. It is used as an antispasmodic in many countries. In the language of professionals, it is called Papaverine hydrochloride. It can be purchased at the pharmacy in several dosage forms. It can be tablets, suppositories or a solution. Its shelf life is 2 years. When visiting a pharmacy, it must be borne in mind that candles and tablets are on sale, and to buy a solution, you will need a prescription confirming the appointment.

How the remedy works

Papaverine can be prescribed in two cases:

• to reduce pressure in the body;
• to relieve muscle pain during spasms.

Its main substance is able to affect certain enzymes, so the muscles of the internal organs relax. This helps relieve pain in the digestive organs, blood vessels or lungs. Pain passes, pressure begins to fall. If the dose of the drug is slightly increased, then a calming effect will also appear. Very often it is used in preparing a person for an operation that will take place under general anesthesia.

When using Papaverine, it is rapidly distributed in the body through the blood, regardless of the form used. The breakdown products of this drug are excreted through the urine.

It is usually prescribed to patients with various diseases. The form is chosen the most convenient for use.

But sometimes injections are preferred:

• with a sharp change in blood pressure;
• with severe bowel disorder;
• if the body temperature rises sharply;
• in case of loss of consciousness by a patient who needs urgent help.

• with pain in the stomach;
• with intestinal and gastric colic;
• in case of constipation or disorders;
• with menstrual pain;
• with spasms in the bladder or its inflammation;
• with a sharp contraction of the muscles of the bronchial wall;
• in case of vasospasm in the brain area.

With individual characteristics, the doctor can use this drug:

• with colic in the kidneys;
• with inflammation of the gallbladder;
• for pain in the chest.

Sometimes it can be prescribed together with Dibazol. This helps reduce pressure. In this case, you need to give an injection intravenously or intramuscularly.

He is also prescribed together with Analgin in ampoules. This helps to normalize body temperature, relieve the patient of pain. Such appointments will be relevant for patients who have undergone surgery.

How the usage depends on the form:

1. The tablet form is used if necessary at any time and washed down well with plain water.
2. Injections with Papaverine can be done subcutaneously or into the muscle. It is best that this is done by a medical worker in a hospital, subject to all sanitary standards. If it is administered intravenously, then it must be diluted with saline.
3. Candles are usually used for pain in the pelvic organs. They need to be inserted into the anus.

So, Papaverine is an antispasmodic, which is available in three different forms (tablets, rectal suppositories and solution in ampoules). The choice in favor of one form or another is made by the doctor based on a number of parameters.

Dosage and possible contraindications

Papaverine has strict restrictions on admission. It should not be used to treat young children under 6 months of age. The same rule applies to people who are over 65 years of age.

Who else is contraindicated Papaverine:

• in violation of the kidneys;
• with abnormal liver function;
• with the development of glaucoma;
• with heart block;
• with a rapid heartbeat;
• in case of malfunction of the thyroid gland;
• with brain injuries.

The dosage should be determined by the doctor in each case. Usually the remedy is not used for a long time, but only if necessary. In the absence of the desired result and if the pain does not stop, then be sure to go to the hospital.

For adult patients, the dose should not exceed 60 mg, if necessary, it can be no more than 240 mg at a time and 720 mg per day.

For medicinal purposes, the doctor may prescribe:

• 3 or 4 tablets per day;
• 2 or 3 candles a day;
• 2 or 4 injections per day.

The form of choice depends on a set of conditions.

Use by pregnant women and children

Sometimes the drug is used to treat children.

The description for the drug establishes the dosage depending on age:

• from 6 months to 2 years, you can take no more than 5 mg;
• from 2 to 7 years, the dose should not exceed 10 mg;
• upon reaching 10 years, it can be no more than 15 mg;
• from 10 to 14 years old, it can increase to 20 mg.

For convenience, you can purchase tablets with a dosage of 10 mg. If you need to use candles, they can be divided in half. For adults, Papaverine 40 mg is suitable.

During pregnancy, it can only be used as directed by a doctor. Papaverine is not able to affect the course of pregnancy, but still it is better not to risk it, especially in the later stages.

Sometimes a large amount of Papaverine can provoke a deterioration in vision, the appearance of a split effect.

Papaverine - instructions for use, reviews, analogs and formulations (40 mg tablets, 20 mg suppositories, injections (in injection ampoules)) for the treatment of spasms in adults, children and pregnancy

In this article, you can read the instructions for using the drug Papaverine. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Papaverine in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Papaverine in the presence of existing structural analogues. Use to treat spasms in adults, children, and pregnancy and lactation.

Papaverine is a myotropic antispasmodic. Reduces the tone of smooth muscles of internal organs (gastrointestinal tract, respiratory, urinary, reproductive system) and blood vessels. Causes the expansion of arteries, promotes an increase in blood flow, incl. cerebral. Has a hypotensive effect.

In high doses, it reduces the excitability of the heart muscle and slows down intracardiac conduction.

When used in medium therapeutic doses, the effect on the central nervous system is weakly expressed.

Bioavailability is 54%. It is well distributed in the body, penetrates through histohematic barriers. Metabolized in the liver. Excreted by the kidneys as metabolites. Completely removed from the blood during dialysis.

• spasms of smooth muscles of the abdominal organs, bronchi, peripheral vessels, vessels of the brain, kidneys;
• angina pectoris (as part of combination therapy).

As an adjuvant for premedication.

Candles for rectal use 40 mg.

Solution for injections (injections in ampoules) 20 mg/ml.

Instructions for use and dosage

Inside - pomg 3-5 times a day. Rectally - pomg 2-3 times a day.

When administered intramuscularly, subcutaneously or intravenously, a single dose for adults is mg; the interval between injections is at least 4 hours. For elderly patients, the initial single dose is not more than 10 mg. For children aged 1 to 12 years, the maximum single dose is mg / kg.

• nausea;
• constipation;
• drowsiness;
• increased sweating;
• arterial hypotension;
• development of AV blockade, cardiac arrhythmias (with rapid administration).

• AV block;
• glaucoma;
• severe liver failure;
• advanced age (risk of developing hyperthermia);
• children's age up to 6 months;
• hypersensitivity to papaverine.

Use during pregnancy and lactation

During pregnancy and lactation (breastfeeding), the safety and efficacy of papaverine has not been established.

Use with caution in conditions after traumatic brain injury, chronic renal failure, adrenal insufficiency, hypothyroidism, prostatic hyperplasia, supraventricular tachycardia, shock conditions.

It should be administered intravenously slowly and under medical supervision.

During the period of treatment, alcohol should be excluded.

With simultaneous use with anticholinergic agents, an increase in anticholinergic effects is possible.

It is believed that when used simultaneously with alprostadil for intracavernous administration, there is a risk of developing priapism.

There are reports of a decrease in the effectiveness of levodopa with its simultaneous use.

Reduces the hypotensive effect of methyldopa.

Analogues of the drug Papaverine

Structural analogues for the active substance:

• papaverine bufus;
• papaverine hydrochloride;
• Papaverine hydrochloride MS;
• Papaverine hydrochloride injection 2%;
• Papaverine hydrochloride tablets for children 0.01 g;
• Candles with papaverine hydrochloride 0.02.

Used to treat diseases: spasm, angina pectoris

How long is papaverine absorbed

Almost every pregnant woman is familiar with the term "uterine hypertonicity". This phenomenon, although quite common, is not a variant of the norm and poses a danger to the course of pregnancy up to its premature termination. Fortunately, modern medicine has a large arsenal of drugs that can effectively relieve tension in the uterine muscles. Among them are the long-known and widely used Papaverine candles. Like any drug, this drug can be used by a pregnant woman only as directed by a doctor, but it is useful for every expectant mother to know all the nuances of its effect on the body and the basic rules for use.

Rectal suppositories Papaverine - the most popular doctor's prescription for uterine hypertonicity

Although Papaverine hydrochloride is actively prescribed by gynecologists to pregnant women for both outpatient and inpatient treatment, the instructions for the drug interpret its use during the gestation period (bearing a child) ambiguously. According to the recommendations provided by the manufacturer, the safety of using Papaverine by expectant mothers has not been established. Of course, this circumstance, combined with the doctor's prescription already received, will confuse a woman who is consciously related to the use of drugs during pregnancy.

It should be noted that clinical studies of the efficacy and safety of the use of the drug Papaverine in pregnant women have not really been conducted. Nevertheless, the long-term practice of using Papaverine clearly indicates its positive effect on the course of pregnancy and, at the same time, its complete safety for the fetus.

Candles with Papaverine are prescribed at any stage of pregnancy if a woman has or suspects the following conditions:

Uterine hypertonicity is the most common diagnosis during pregnancy. Hypertonicity is a tension in the myometrium (the muscular layer of the uterus), which can occur for a number of reasons (stress, excessive physical activity, hormonal causes, etc.) and can lead to premature termination of pregnancy. Arterial hypertension - a persistent increase in blood pressure - is a fairly common phenomenon in late pregnancy. Colic (hepatic, renal, intestinal, etc.) - sudden cramping pain caused by muscle spasm. Bronchospasm is an abnormal narrowing of the bronchi. A strong increase in body temperature (in such cases, Papaverine is used as part of a lytic mixture).

Papaverine is also able to have a positive effect on constipation, if they are caused by muscle spasm (spastic constipation). With atonic constipation, which is caused by a decrease in the tone of the intestinal muscles, Papaverine will only aggravate the situation.

The drug Papaverine is produced in several pharmaceutical forms:

injection solution; rectal suppositories; tablets.

During pregnancy, Papaverine is most often prescribed in the form of suppositories - suppositories. This form has several advantages:

convenience and versatility of self-use by a woman; complete and rapid absorption of the drug through the rectum; increased therapeutic effect due to the proximity of the uterus.

Each rectal suppository of Papaverine contains 20 mg of the active ingredient.

The active substance of this drug is papaverine hydrochloride, a myotropic antispasmodic. In this regard, the drug acts in two directions:

Relieving the tension of the smooth muscles of the internal organs (the remedy affects not only the uterus, but also the organs of other systems - urinary, digestive, respiratory). Vasodilation and an increase in blood flow, due to which the drug is able to reduce blood pressure (hypotensive effect).

With regular intake of Papaverine, women note its sedative effect - the level of anxiety is significantly reduced, the heart rate stabilizes, which has the most positive effect on the course of pregnancy.

The mechanism of action of the drug in the form of rectal suppositories is as follows:

The suppository, after being placed in the rectum, melts under the influence of body temperature. The active substance is instantly absorbed into the blood. In plasma, papaverine binds to proteins. The bloodstream carries papaverine to all systems and organs of a woman, including the muscle tissue of the uterus. The active substance of the drug has a relaxing effect on smooth muscles. Papaverine is excreted from the body by the kidneys in the form of metabolites (intermediate metabolic products).

The treatment regimen with Papaverine during pregnancy is prescribed only by a doctor in accordance with the individual characteristics of the woman's body and the diagnosis. As a rule, the period of taking the drug is 2-3 weeks, the daily dose is 2-4 suppositories. Receptions of the drug are distributed evenly throughout the day.

It is important to remember that Papaverine suppositories are only available for rectal use - they should never be used vaginally.

The rules for the introduction of rectal suppositories are as follows:

Wash your hands thoroughly before inserting the suppository. Since candles melt very quickly upon contact with hands, before opening the blister, you can hold the unpacked candle in the refrigerator or under running cold water for some time. For the introduction of the suppository, it is convenient to use disposable gloves or fingertips. It is better to administer the drug in the supine position. The candle must be placed behind the muscular sphincter, pushing it 2.5–5 cm deep. After the introduction of the drug, it is better to lie on your side for a few more minutes to avoid leakage. After completing the procedure, wash your hands thoroughly.

It is most convenient to insert rectal suppositories in the supine position

As a rule, suppositories with Papaverine are easily tolerated by pregnant women, however, in isolated cases (with prolonged and uncontrolled use), the following side effects may occur:

redness and itching of the skin (allergic reaction); drowsiness; dizziness; heart rhythm disturbances; increased sweating; lowering blood pressure; constipation; nausea.

Rectal suppositories with Papaverine are contraindicated in the presence of the following conditions and diseases:

individual intolerance to the components of the drug; glaucoma; liver or kidney failure; heart rhythm disturbances; AV block (atrioventricular block).

Papaverine is used with caution in case of impaired adrenal function, hypothyroidism and arterial hypotension (low blood pressure).

Complete analogues of rectal suppositories with Papaverine are only preparations of other pharmaceutical forms of release - tablets and injections. If we talk about medicines of similar action, then in modern gynecology such drugs as No-shpa, Magne B6, Utrozhestan are used. Their effect is based on the antispasmodic properties of other active ingredients.

Papaverine is a combined antihypertensive drug that has antispasmodic and analgesic effects. Persons who suffer from angina pectoris and suffer from intestinal colic are well acquainted with its action. For those who were first prescribed Papaverine, we will tell you about its use, composition and contraindications, as well as cases in which this medication is not taken.

Composition and form of release

There are quite a few forms of release for this drug. The active substance of the drug is the papaverine hydrochloride component. Papaverine is produced in the form of:

• conventional tablets containing 40 mg of the active substance;
• tablets for children - 10 mg of the active ingredient in one tablet;
• solution for intravenous or intramuscular administration, 1 ml of which contains 20 mg of the active substance;
• rectal suppositories (candles), each of which contains 20 mg of papaverine hydrochloride.

pharmachologic effect

This medicine belongs to the group of myotropic antispasmodics. Papaverine has analgesic, antihypertensive and antispasmodic effects. It effectively reduces the tone of the smooth muscles of the respiratory, reproductive, urinary systems, stomach, and blood vessels, relieving spasms and convulsions. Once in the body, the agent expands the arteries, increases blood flow, including cerebral. In addition, Papaverine in high doses has a sedative effect, can reduce myocardial excitability and slow down intracardiac conduction.

The safety of the drug during pregnancy has not been studied.

Indications for use

Papaverine is usually classified into two categories - vasodilators (vasodilators) and anti-spasm drugs (antispasmodics). This drug can be prescribed for a variety of spasms of smooth muscles of the internal organs of the gastrointestinal tract, urinary and circulatory systems. These include:

• intestines;
• stomach;
• kidneys;
• uterus;
• bladder;
• gallbladder;
• heart;
• respiratory system.

Papaverine also relieves spasms of peripheral vessels and cerebral vessels.

The drug is used in various branches of medicine:

• urology;
• general therapy;
• gynecology;
• surgery;
• traumatology;
• gastroenterology.

The main diseases for which papaverine is used:

• cholecystitis (inflammation of the gallbladder);
• colitis (inflammation of the large intestine);
• cholangitis (inflammation of the bile ducts);
• flatulence (flatulence);
• constipation;
• stomach and intestinal colic;
• pain during menstruation;
• uterine hypertonicity;
• urethritis (inflammation of the urethra);
• cystitis (inflammation of the bladder);
• urolithiasis disease;
• renal colic;
• pyelitis;
• spasms of the bile ducts;
• spasm of the ureter, leading to urinary retention;
• spasms of cerebral vessels and headaches;
• pylorospasm (spasm of the muscles of the pylorus of the stomach);
• endoarteriitis (vascular damage - mainly the vessels of the legs);
• angina;
• bronchospasm;
• hypertension;
• haemorrhoids.

As an aid, Papaverine can be used in the case of premedication, that is, with medical preparation for surgical intervention.

Dosing regimen

Papaverine tablets:

• adults should take the drug up to 4 r / day, 1 tablet (40 mg);
• a single dose for children under 2 years old is 5 mg;
• for children under 6 years old - 10 mg;
• up to 9 years - 15 mg;
• for adolescents under 14 years old - 20 mg.

Children also need to take the remedy up to 4 r / day.

Rectal suppositories

Suppositories are prescribed exclusively for adults, and they take one suppository (20 mg of medication) 3 r / day.

Features of the use of suppositories

Rectal suppositories with papaverine are used to treat hemorrhoids. Candles do the following:

• facilitate the process of emptying the intestines;
• relieve pain syndrome;
• reduce the intensity of bleeding.

In diseases of the genitourinary system, Papaverine is also preferable to use in the form of suppositories. In such cases, suppositories are more effective than tablets.

Injection

Subcutaneously, intravenously or intramuscularly Papaverine is administered in a single dose of 20–40 mg up to 4 r / day. Before intravenous administration, the drug is diluted in 20 ml of sodium chloride solution. At least 4 hours should elapse between injections. Intravenous, as well as intramuscular administration, should be carried out under the supervision of a specialist and always slowly.

The maximum dose of the drug for one subcutaneous or intramuscular injection is 100 mg, and for intravenous administration, the maximum dose per day is 120 mg.

Elderly people, as well as patients with decompensated heart failure and supraventricular tachycardia, endocrine diseases, in a state of shock, begin to administer the drug with 10 mg (single dose).

Children from 1 to 12 years of age can be given medication based on body weight at the rate of 0.7 mg per kg, 2 r / day.

Papaverine during pregnancy

Despite the fact that there is no data on the safety of Papaverine during pregnancy, nevertheless, it is quite often used in gynecology for uterine hypertonicity, which is fraught with premature birth. Most often, the drug is prescribed in the early stages of pregnancy, but it is usually used in combination with hormonal drugs.

In the later stages of bearing a child, to prepare the uterus for childbirth, Papaverine is prescribed in combination with Drotaverine.

Treatment of pathologies in expectant mothers with the use of Papaverine is carried out only in a hospital, while the dosage must be selected extremely carefully and self-medication is not permissible. For therapy, all forms of the drug are used: tablets, injections and suppositories. In the first trimester, suppositories with Papaverine are most often used, they act with a higher speed and efficiency than tablets.

Contraindications of the drug

Papaverine is not prescribed for:

• advanced age (risk of hyperthermia);
• the presence of glaucoma;
• the age of the child is up to 6 months;
• glaucoma;
• severe liver failure;
• AV block;
• hypersensitivity to the components of the remedy.

Papaverine should be used with caution when:

• hypothyroidism (decreased thyroid function);
• adrenal insufficiency;
• renal failure in a chronic form;
• prostate hyperplasia (adenoma),
• supraventricular tachycardia,
• shock states,
• craniocerebral injuries.

At the age of more than 65 years, the drug is used under strict medical supervision.

Some drugs are incompatible with Papaverine, so it is best to consult a doctor before taking the drug.

Given that the safety of the drug during lactation and during childbearing has not been established, it is forbidden to take the drug during these periods.

Side effects

In some cases, taking Papaverine can cause:

• arterial hypotension;
• drowsiness;
• nausea and vomiting;
• ventricular extrasystole;
• allergic reactions;
• increased sweating;
• constipation;
• eosinophilia;
• AV blockade.

Some allergic reactions are also not excluded - itching, Quincke's edema, urticaria, and in exceptional cases even anaphylactic shock.

Doctors pay attention that with the rapid administration of the drug, as well as with the introduction of it in high doses, there is a risk of heart rhythm disturbances. In case of an overdose, muscle weakness, diplopia and a decrease in blood pressure may occur.

Interaction

In combination with barbiturates, the antispasmodic effect of the drug is enhanced, and with tricyclic antidepressants, procainamide, reserpine, quinidine, an increase in the hypotensive effect of Papaverine is possible.

Drug analogues

The means that are structural analogues of the described drug include: Papaverine hydrochloride, Papaverine hydrochloride MS and Papaverine bufus.

Papaverine is a drug that is widely used in modern medicine. Due to the fact that there are several forms of release, it can be prescribed by a specialist to people with varying degrees of susceptibility. Indications for the use of Papaverine are different, therefore, in hospitals, for example, injections are used, at home you can use tablets or suppositories.

Release form and composition

Papaverine belongs to the group of opioid alkaloids produced by synthesizing various components. Its main active ingredient is papaverine hydrochloride. The drug is available in three dosage forms:

• Tablets. Produced in blisters of 10 pieces. Each tablet contains 40 mg of the active ingredient, in the preparation for children its share is less and is only 10 mg.
• Injection. Available as 2 ml ampoules, each contains the same amount of active ingredient as the tablets. Packed in cardboard boxes of 5 and 10 pieces (together with a special ampoule knife).
• Rectal suppositories. Candles contain 20 mg of papaverine hydrochloride and are intended for injection into the rectum. They are packed in special packs of 5 pieces each.

Papaverine - a drug that can be found in any pharmacy

Pharmacological action of the drug

Papaverine hydrochloride inhibits the activity of an enzyme called phosphodiesterase, which in turn provokes the accumulation of cyclic adenosine monophosphate at the cellular level. After that, the level of calcium decreases and as a result, this leads to the fact that smooth muscles relax, and the number of their contractions returns to normal.

The drug is able to save a person from the stomach and other organs of the digestive system, bronchi, uterus, kidneys, bladder and gallbladder. When exposed to the components of the drug, there is an exceptionally relaxing effect, elasticity and proper movements of all muscle groups are preserved in full.

What helps papaverine

As mentioned earlier, Papaverine is an antispasmodic, which also has a hypotensive and anticonvulsant effect. What is papaverine used for?

• providing a sedative effect when prescribed by a specialist in large doses;
• vasodilation;
• decreased tone of smooth muscles of the genitourinary and respiratory systems, as well as the heart;
• improved blood flow.

After entering the body, the drug begins to be absorbed almost immediately, the maximum effect of Papaverine is achieved within half an hour. Excreted from the body through the kidneys.

Recommendation: if there is an urgent need to remove all components of the drug from the body, then you can resort to dialysis. During this procedure, the blood is completely cleansed of toxins, as well as unnecessary and harmful substances.

When is Papaverine prescribed?

The main indications for the use of Papaverine are muscle spasms that occur in the following cases:

• endarteritis is a disease in which the lumen in the arteries is completely blocked, which entails a violation of blood flow. Along with this, damage to internal organs begins and gangrene develops. For the most part, this ailment affects the vessels located in the lower extremities;
• inflammation of the bronchi, in which bronchospasm is by no means a rare occurrence;
• diseases of the abdominal organs - colitis, cholecystitis, renal colic;
• angina, in which certain parts of the heart stop receiving blood in the right amount. The disease is characterized by blockage or narrowing of blood vessels, as a result of which severe chest pains develop against this background;
• problems associated with vessels located in the brain;
• with exacerbation of attacks of gallstone disease.

Papaverine can also be used for surgical intervention. It is administered by an anesthetist to reduce the tone of the airway muscles. Thanks to this organism, the patient will be much easier to endure anesthesia.

Papaverine acts on smooth muscles by regulating their tone.

Is it possible to take papaverine during pregnancy

The vast majority of women in position are faced with such a phenomenon as uterine hypertonicity. This condition is considered quite dangerous because it can provoke premature birth. Even during seizures, blood flow to the fetus decreases, which entails negative consequences - the child simply does not receive all the necessary nutrients and substances. To reduce muscle tone, women are prescribed Papaverine, which can also lower blood pressure if it suddenly rises. Along with this, there is an improvement in blood flow to the uterus, which positively affects the development of the child.

Another positive property of Papaverine is that it has a sedative effect. It relieves nervous tension, which is characteristic of many pregnant women, namely, it is known that it can provoke the development of uterine tone.

Important: take the antispasmodic Papaverine during pregnancy should be cautious, at the slightest suspicion of a deterioration in the condition, you should stop taking it and consult a doctor.

A number of side effects are possible:

• an allergic reaction is rare, but possible. Most often, women are concerned about itching on the skin and urticaria;
• dizziness;
• drowsiness;
• constipation;
• when administered intravenously, cardiac arrhythmias may occur.

A completely logical question that arises in many women is where, in fact, to insert suppositories (if such a dosage form was prescribed), if they are intended for rectal administration, and it is necessary to have a therapeutic effect in the genitourinary system? The answer is simple - where it is shown, since the active ingredients are quickly absorbed into the bloodstream and are first distributed locally to nearby organs, and then further throughout the body. This contributes to the fact that the smooth muscles of the uterus will be saturated with the substances of the drug in full and in a short time.

Papaverine is often prescribed during pregnancy, as it can alleviate the condition of a woman.

Contraindications - to whom and when Papaverine is prohibited

In order to avoid the appearance and development of allergic reactions, you should not take Papaverine if there is an individual intolerance to the active substance or other components of the drug. Treatment with the drug should be interrupted immediately if signs of allergy are found. The instruction to the medicine says that the contraindications to Papaverine are as follows, and it is forbidden to take it:

• small children (up to 6 months);
• To old people;
• those who have arterial hypotension (low blood pressure);
• patients with glaucoma;
• people with renal insufficiency (the kidneys simply will not be able to fully remove the components of the drug from the body);
• hospital patients in a coma.

With extreme caution, Papaverine should be taken by those who are diagnosed with:

• traumatic brain injury;
• hypothyroidism;
• prostatic hyperplasia;
• state of shock;
• supraventricular tachycardia;
• adrenal dysfunction.

Side effects

The cardiovascular system

It is possible to develop atrioventricular blockade - a condition in which the electrical impulse between the ventricles and the atria slows down or stops altogether. This leads to a heart rhythm disorder. Along with this, a decrease in blood pressure and ventricular tachycardia are possible.

Gastrointestinal tract

Here are possible:

• nausea and vomiting;
• dysfunction of the passage of food through the intestines.

All other side effects of Papaverine include allergic reactions, excessive drowsiness and eosinophilia - an increase in the blood level of special cells responsible for fighting toxins and various microorganisms.

It should be remembered that by themselves side effects develop extremely rarely. They can appear only in those cases when a person independently and without consulting a specialist began taking Papaverine or when he significantly exceeded the dosage recommended by the doctor.

During pregnancy, a woman tries to protect herself from all sorts of negative influences and factors that can lead to complications. And this includes not only all kinds of diseases, but also disorders, experiences, as well as stressful situations that pose a threat to the normal development of the baby and the preservation of pregnancy. Unfortunately, it is far from always possible to isolate oneself from stress, and sometimes situations arise that require medical assistance. Nervous tension and stress cause anxiety in the baby, because of which he becomes mobile. Its movements cause the uterus to tense up, increasing the tone, which can cause it to contract and endanger the preservation of the pregnancy. In this case, in order to prevent negative consequences, the doctor may prescribe special drugs, one of which is suppositories with papaverine during pregnancy.

Candles Papaverine or Papaverine hydrochloride, refers to drugs of the antispasmodic group, the purpose of which is to relax smooth muscle cells. Its effect is on all systems and organs of the human body, in which there are smooth muscles, including blood vessels. It is this drug that is one of the few drugs that are so often used during the period of bearing a baby.

Candles Papaverine or Papaverine hydrochloride during pregnancy are administered rectally, while the drug does not have any negative effect on the fetus, but, on the contrary, helps to maintain the pregnancy in case of a threat of termination, as it perfectly reduces the increased uterine tone and blood flow in the placental-uterine circle.

The main effect of the drug is aimed at:

• reduction of muscle tension and relaxation of the muscles of internal organs;
• improvement of blood circulation in soft muscles, especially in the muscles of the uterus;
• decrease in blood pressure with its sharp increase;
• stabilization of the heart rate.

The drug is produced in three types:

• tablets;
• solutions for injection (intravenous, intramuscular, subcutaneous);
• rectal suppositories.

During pregnancy, the doctor may prescribe not only suppositories with papaverine, but also an injection solution. And here it is important to take into account one point: if intravenous injections are prescribed, then they should be carried out only in a hospital under the constant supervision of a doctor.

The introduction of this form of the drug should be carried out very slowly. When prescribing subcutaneous or intramuscular injections, treatment can be carried out at home.

Most often, during pregnancy, doctors prescribe papaverine suppositories. This form of release is versatile and convenient enough to quickly reduce to normal if necessary.

Overexertion of the uterus during the development of a baby in it can lead to miscarriage in the early stages and in the later ones. The uterine muscles cannot relax on their own. A child growing in it constantly stretches its walls, which leads to strong tension.

Indications for use

Among the direct indications for the use of Papaverine in various forms can be noted:

1. Threat of miscarriage due to uterine hypertonicity. It is this reason that is most often the basis for the appointment of Papaverine during pregnancy.
2. Arterial hypertension. Thanks to the drug, the decrease in high blood pressure occurs gently, without creating a threat to the fetus.
3. Colic of various types. For example, intestinal, renal, hepatic. In this case, the substance relaxes the excretory ducts that have undergone spasms, restoring the natural functions of the organ and relieving pain.
4. Bronchospasm. Thanks to the action of the drug, the lungs are relaxed and the normal respiratory function is quickly restored, as well as the general condition is improved.
5. Presence of high temperature body. Papaverine in this case can be used as part of a lytic mixture.

Is it possible to use papaverine hydrochloride suppositories during pregnancy?

During the period of nine months of bearing a baby, few women at least once will not resort to the help of this drug. Someone reduces their increase in uterine tone regularly, and someone uses the remedy only occasionally, for example, after a hard day's work or a long stay on their feet, as well as during periods of severe stress, in order to save themselves from possible problems and eliminate risks to the fetus.

The instructions for Papaverine suppositories during pregnancy say that there is no data indicating the effect of the drug on the body. At the same time, in the course of clinical observations over the years of use of the drug by pregnant women, no negative effect on the fetus and the course of pregnancy has been established. Of course, it is not worth prescribing such a drug on your own, since only a specialist can correctly assess the condition of the female body and establish the need for the use of the drug.

Papaverine hydrochloride has a pronounced antispasmodic effect of a myotropic nature, affecting not only the muscles of the uterus, but also the smooth muscles of many other organs, such as the respiratory, urinary, and reproductive systems. The action of the drug also extends to the gastrointestinal tract. Influencing the smooth muscles of blood vessels, the drug contributes to their expansion, which significantly improves blood flow and reduces pressure. During pregnancy, Papaverine is most often used to eliminate spasms of many internal organs, peripheral vessels and vessels of the brain, bronchi, uterine hypertonicity and improve placental blood flow.

The dosage of suppositories with papaverine during pregnancy is set by the doctor, but in most cases suppositories should be administered 2 to 4 times a day, while observing equal time intervals. The duration of treatment in each case will be individual, it depends on the symptoms and condition of the patient. On average, treatment can last from several days to a month, but sometimes longer.

Once in the rectum, the suppository begins to dissolve under the influence of body temperature, gradually releasing the medicinal substance, which is absorbed into the bloodstream and supplied by the circulatory system to all organs, affecting the vessels along the way. Under the action of the drug, the level of excitability of the uterine muscles is significantly reduced, pain and tension are eliminated, and blood pressure is also lowered, which is necessary for many pregnant women in the later stages.
So, to the question of where to put candles with papaverine during pregnancy, each doctor will answer - in the rectum exclusively in the rectal way. Under no circumstances should they be used vaginally.

Contraindications and side effects

Each drug has side effects, as well as prohibitions and restrictions on use. Given the hypotensive effect, the drug should not be used in women with hypotension (low blood pressure).

The use of Papaverine suppositories during pregnancy is contraindicated in the following cases:

• the presence of ocular glaucoma;
• violation of the heart rhythm;
• tachycardia;
• the presence of atrioventricular blockade;
• severe liver or kidney failure;
• an allergic reaction to any component of the drug.

In some cases, candles can only be used with caution, and this category includes not only pregnancy, but also a violation of the adrenal glands, the functions of the pituitary gland, as well as hypothyroidism.

The use of Papaverine suppositories during breastfeeding deserves special attention. To date, there are no reliable data on the effect of the substance on the baby during this period. However, doctors of many clinics and scientific centers do not recommend the use of suppositories during lactation. If there is an urgent need for their use, it is better to temporarily (for the period of therapy) wean the baby from the breast, and after treatment, resume feeding.

Despite the good therapeutic effect and safety for the baby, it is not worth abusing the use of Papaverine suppositories.

Among the side effects most often observed:

• hyperemia of the skin, caused by excessive expansion of blood vessels;
• the appearance of itching;
• a feeling of fatigue and drowsiness due to the sedative effect of the drug;
• dizziness, darkening in the eyes when changing the position of the body;
• violation of the heart rhythm;
• decrease in blood pressure (sometimes below the permissible minimum values);
• unpleasant and uncomfortable sensations in the abdomen;
• nausea;
• constipation;
• increased sweating.

Despite the safety of Papaverine for fetal development and the effective help of the drug in terms of maintaining pregnancy, self-medication is not worth it.

Only a doctor should prescribe the use of Papaverine suppositories during pregnancy if there are indications for this drug and the need for its use. Therefore, if any symptoms of malaise, colic, tension of the uterus appear, in the event of severe stressful situations, you should immediately consult a doctor. Candles with papaverine can greatly alleviate the condition of a pregnant woman if all the doctor's recommendations on the method of using the drug are followed. And when a woman knows where to administer papaverine suppositories during pregnancy, this will help her quickly relieve tension in the uterus, which is a very important point.

Useful video about uterine hypertonicity

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