Persen ® (Persen ®). Persen - instructions for use, indications, contraindications, side effects, analogues, reviews, prices Side effects and overdose

Herbal sedative.
Preparation: PERSEN®
The active substance of the drug: Melissa, Peppermint, Valerian
ATX encoding: N05CM
KFG: Phytopreparation with a sedative effect
Registration number: P No. 016317/01
Date of registration: 27.05.05
The owner of the reg. credit: LEK d.d. (Slovenia)

Release form Persen, drug packaging and composition.

Tablets, film-coated dark brown, round, biconvex.

1 tab.
dry extract of valerian
50 mg
peppermint dry extract
25 mg
dry extract of lemon balm
25 mg

Excipients: microcrystalline cellulose, corn starch, crospovidone, lactose, talc, magnesium stearate, colloidal silicon dioxide, hydroxypropylmethylcellulose, sodium carboxymethylcellulose, povidone, calcium carbonate, glycerol, sucrose, dyes (brown 75, titanium dioxide, wax E Hoechst (Capol 600 )).

10 pieces. - blisters (4) - packs of cardboard.

Persen® forte

Reddish-brown capsules; the contents of the capsules are granules or a compressed brown mass with inclusions.

1 caps.
dry extract of valerian
125 mg
peppermint dry extract
25 mg
dry extract of lemon balm
25 mg

Excipients: lactose, magnesium oxide, talc, colloidal silicon dioxide, magnesium stearate, dyes (orange-yellow "sunset", titanium dioxide, iron oxide (E172), quinoline yellow, azorubine), preservatives (methylhydroxybenzoate, propylhydroxybenzoate).

10 pieces. - blisters (2) - packs of cardboard.

The description of the drug is based on the officially approved instructions for use.

Pharmacological action Persen

Herbal sedative. It has a sedative and antispasmodic effect.

The extract of rhizomes with valerian roots causes a moderately pronounced sedative effect.

Melissa extract and peppermint extract have a sedative and antispasmodic effect.

Pharmacokinetics of the drug.

The action of the drug is the result of the cumulative action of its components, so it is not possible to conduct kinetic observations; all together the components cannot be traced using markers or bioassays. For the same reason, it is impossible to detect drug metabolites.

Indications for use:

Increased nervous excitability;

Insomnia;

Irritability.

Dosage and method of application of the drug.

Adults and adolescents over 12 years old are prescribed 2-3 tablets. or 1-2 caps. The drug is taken 2-3 times / day.

With insomnia - 2-3 tab. or 1-2 caps. 1 hour before bed.

For children aged 3 to 12 years, the drug is prescribed only under medical supervision and only in the form of tablets. The dose depends on the patient's body weight and averages 1 tab. 1-3 times / day.

Restrictions on the duration of the drug are not provided.

Side effects of Persen:

Perhaps: allergic reactions; with prolonged use - constipation.

Contraindications to the drug:

arterial hypotension;

Children's age up to 3 years (for coated tablets);

Children's age up to 12 years (for capsules);

Hypersensitivity to the components of the drug.

Use during pregnancy and lactation.

The use of the drug during pregnancy and lactation has not been studied. The appointment of the drug during pregnancy (especially in the first trimester) and during breastfeeding is possible only in cases where the intended benefit to the mother outweighs the potential risk to the fetus or infant.

Special instructions for the use of Persen.

When the drug is discontinued, withdrawal syndrome does not occur.

Do not use the drug continuously for more than 1.5-2 months.

Pediatric use

The question of the possibility of prescribing the drug in the form of coated tablets for children aged 3 to 12 years is decided by the doctor individually.

The drug in the form of capsules is used only in children over 12 years of age.

Influence on the ability to drive vehicles and control mechanisms

Drug overdose:

Symptoms: a single dose of 20 g of rhizomes with valerian roots (approximately 103 tablets or 39 capsules of Persen forte) can cause non-dangerous phenomena: feelings of fatigue, stomach cramps, chest tightness, dizziness, tremor, pupillary dilation, which can pass on their own in within 24 hours

Treatment: gastric lavage; if necessary, carry out symptomatic therapy.

Interaction of Persen with other drugs.

With the simultaneous use of Persen with other drugs that depress the central nervous system (including hypnotics, antihypertensive drugs of central action, analgesics), it is possible to increase the effect on the central nervous system (dose adjustment may be required).

Conditions of sale in pharmacies.

The drug is approved for use as a means of OTC.

Terms of the storage conditions of the drug Persen.

The drug should be stored in a dry place, out of the reach of children, at a temperature not exceeding 25°C. Shelf life - 3 years.

In this article, you can read the instructions for using the drug Persen. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Persen in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Persen's analogues in the presence of existing structural analogues. Use to treat excitability, irritability and insomnia in adults, children, and pregnancy and lactation. The composition of the drug.

Persen- a herbal sedative. It has a sedative and antispasmodic effect.

The extract of rhizomes with valerian roots causes a moderately pronounced sedative effect.

Melissa extract and peppermint extract have a sedative and antispasmodic effect.

Compound

Extract of valerian rhizomes with roots (dry) + extract of lemon balm leaves (dry) + extract of peppermint leaves (dry) + excipients.

Pharmacokinetics

Indications

increased nervous excitability;
insomnia;
irritability.

Release forms

Coated tablets.

Capsules Persen forte.

Instructions for use and dosage

Adults and adolescents over 12 years old are prescribed 2-3 tablets or 1-2 capsules. The drug is taken 2-3 times a day.

For insomnia - 2-3 tablets or 1-2 capsules 1 hour before bedtime.

Do not use Persen Forte continuously for more than 1.5-2 months.

Side effect

allergic reactions;
with prolonged use - constipation.

Contraindications

arterial hypotension;
children's age up to 3 years (for coated tablets);
children's age up to 12 years (for capsules);
hypersensitivity to the components of the drug.

Use during pregnancy and lactation

The use of the drug during pregnancy and lactation has not been studied. The appointment of the drug during pregnancy (especially in the 1st trimester) and during breastfeeding is possible only in cases where the intended benefit to the mother outweighs the potential risk to the fetus or infant.

special instructions

When the drug is discontinued, withdrawal syndrome does not occur.

Do not use the drug continuously for more than 1.5-2 months.

Influence on the ability to drive vehicles and control mechanisms

drug interaction

Analogues of the drug Persen

Persen has no structural analogues for the active substance.

Analogues for the therapeutic effect (sedatives):

Altalex;
Bellaspon;
Belloid;
Bromocamphor;
Valdispert;
Valerian;
Valerian Forte;
Validol;
Gelarium Hypericum;
Glycine;
Dexdor;
Deprim;
Doppelhertz Nervotonik;
Dormiplant;
Oregano herb;
St. John's wort;
Life 600;
Life 900;
Melison;
Melissa officinalis herb;
Negrustin;
Neurobutal;
Nervoflux;
Nobrassite;
Novopassit;
Passiflora extract;
Peony evasive tincture;
Motherwort tincture;
Sanason Lek;
Pretty;
Stressplant;
Ethyl bromoisovalerianate.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

One coated tablet contains:
- 35 mg dry water-alcohol extract of valerian roots (Valeriana officinalis L.) (4-7:1); extractant: ethanol 70% (v/v);
- 17.5 mg dry extract of lemon balm leaves (Melissa officinalis L.) (3-6:1); extractant: ethanol 50% (v/v);
- 17.5 mg of dry extract of peppermint leaves (Mentha piperita L.) (3-6:1); extractant: ethanol 40% (v/v).
Excipients:
core: lactose monohydrate, microcrystalline cellulose, corn starch, crospovidone, talc, colloidal anhydrous silica, magnesium stearate, liquid glucose, maltodextrin, peppermint flavor powder;
shell: hypromellose, carmellose sodium, povidone, sucrose, colloidal anhydrous silicon dioxide, calcium carbonate, brown iron oxide (E172), titanium dioxide (E171), glycerin, talc, montan glycol wax.

Description

Round, biconvex brown coated tablets.

Pharmacological group

Other sleeping pills and sedatives.
ATX code: N05CM.

Pharmacological properties

The drug has a sedative and antispasmodic effect.
The rhizome extract with valerian roots has a calming effect.
Melissa leaf extract - soothing and antispasmodic effect.
Peppermint leaf extract - antispasmodic, moderate sedative effect.

Indications for use

In the complex therapy of mild functional disorders of the central nervous system (neurasthenia and sleep disorders).
The use of the medicinal product is based solely on the experience of traditional long-term use.

Contraindications

Hypersensitivity to the components of the drug, children under 12 years of age, arterial hypotension, pregnancy, lactation.

Dosage and administration

Adults and children over 12 years old
With increased nervous excitability, irritability - 3 coated tablets, 3 times a day;
in case of sleep disorders, it is recommended to take 3 coated tablets half an hour - 1 hour before bedtime.
Tablets should be taken with a small amount of boiled water at room temperature (1/4 cup), regardless of the meal.
The effect of taking the drug Persen develops gradually. To achieve the optimal effect, it is recommended to take the drug for at least 14 days. The duration of the course of treatment is determined by the doctor, taking into account the disease, the tolerance of the drug and the effect achieved.
If symptoms persist after taking the drug for fourteen days or if the condition worsens, you should consult a doctor.
Use in children
Due to the lack of data on safety and efficacy, Persen is not recommended for children under 12 years of age.

Side effects

The frequency of adverse reactions listed below: very often (≥1/10), often (≥1/100 to<1/10), нечасто (≥1/1000 до <1/100), редко (≥1/10000 до <1/1000), очень редко (<1/10000), не известно (не может быть оценена на основании доступных данных).
Perhaps the development of allergic reactions, bronchospasm.
Gastrointestinal Disorders
Not known: Nausea, spasmodic abdominal pain. With prolonged use - constipation.
May increase the symptoms of gastroesophageal reflux (heartburn).
In case of adverse reactions, including those not listed in the instructions for use, you should consult a doctor.

Use during pregnancy and lactation

The safety of use during pregnancy and lactation has not been established. Due to the lack of sufficient data, it is not recommended to use during pregnancy and lactation.

Influence on the ability to drive a car and work with mechanisms

Taking Persen may impair the ability to drive and use machines. During treatment, it is not recommended to drive a car and work with mechanisms.

Overdose

A single intake of 20 g of valerian root extract with rhizomes (approximately 103 Persen tablets) can cause general weakness, spastic abdominal pain, chest tightness, dizziness, hand tremors and dilated pupils.
In case of symptoms of an overdose, you should consult a doctor. Treatment is symptomatic.

Interaction with other drugs

There is limited information on interactions between Persen and other medicinal products. Before taking other medicines, the patient should consult a doctor. Clinically significant interactions with substances that are metabolized by CYP 2D6, CYP 3A4 / 5, CYP 1A2 and CYP 2E1 have not been observed. Simultaneous administration of the drug Persen with synthetic sedatives (for example, benzodiazepines) is not recommended and is allowed only under medical supervision.

special instructions

Patients with gastroesophageal reflux (heartburn) should avoid taking medicinal products containing mint due to possible aggravation of heartburn.
Patients with gallstone disease, other diseases of the gallbladder and biliary tract should not take peppermint leaf preparations without medical supervision.
One tablet contains 99.5 mg lactose monohydrate, 66.988 mg sucrose and 14 mg liquid glucose. The content of sucrose and glucose must be taken into account when prescribing the drug to patients with diabetes mellitus.
Due to the lactose content, patients with galactose intolerance, lactase deficiency or glucose/galactose malabsorption syndrome should not take Persen.
Due to the sucrose content, patients with fructose intolerance, glucose/galactose malabsorption syndrome or sucrase-isomaltase deficiency should not take Persen.
Due to the glucose content, patients with glucose/galactose malabsorption syndrome should not take Persen.
If symptoms persist while taking the drug or if the condition worsens, you should consult a doctor.

Persen is a popular herbal sedative that is prescribed to adults for sleep problems or stress. But is it possible to give this remedy to children, in what cases and in what dosage?

Release form and composition

Persen is available in tablets, which have a convex round shape and a dark brown shell. They are placed in blisters of ten pieces and are sold in 2-8 blisters in one box. Each tablet contains the following dry extracts as active substances:

From valerian - 50 mg.
From lemon balm - 25 mg.
From peppermint - 25 mg.

Corn starch, MCC, lactose, crospovidone and some other ingredients are added to them, providing density to the core of the tablet. The drug shell is made of wax, povidone, sucrose, calcium carbonate, glycerin and other substances.

In addition to the usual Persen, in pharmacies there are two more options for such a medication - Persen Forte and Persen Night. Both of these drugs are presented in capsules and contain the same components as Persen tablets, but valerian is presented in a higher dosage (125 mg in one capsule). The medication is sold in packs of 10 to 80 red-brown capsules.

Operating principle

All components of Persen have a calming effect, and also have antispasmodic properties. Taking the drug helps to reduce the excitability of the nervous system and improve sleep.

Indications

Persen is prescribed for:

Stress and nervous overload.
Strong irritability, restlessness and nervousness.
Insomnia and trouble falling asleep.
Increased excitability of the CNS.
Neurosis of average or weak expressiveness.

The same indications for the drug Forte, and Persen Night are prescribed mainly for sleep disorders.

At what age are they prescribed?

Both Persen tablets and Noch or Forte capsules are prescribed for children over 12 years of age.

If a medicine is required for a younger patient, for example, for a child of 7 years old, together with the doctor they select a remedy with a similar effect, but allowed by age.

Contraindications

Persen tablets, as well as Noch and Forte capsules are not used if the patient has:

Increased sensitivity to lemon balm, valerian, mint or auxiliary ingredients of tablets.
There is no sucrase, lactase or isomaltase in the body.
Have fructose or lactose intolerance.
Reduced blood pressure.
There are pathologies of the biliary tract.

Children with gastroesophageal reflux require caution in the treatment with Persen.

Side effects

The drug can provoke an allergy in the form of skin redness, swelling, dermatitis, bronchospasm, rash and other symptoms. Prolonged use of tablets sometimes causes constipation. There are no negative effects (withdrawal syndrome) after the end of the intake .

Instructions for use

The tablet should be swallowed and washed down with water. The diet does not affect the time of taking Persen. A single dose of the drug is 2-3 tablets, and it is advised to take them with irritability or nervous excitability twice / thrice a day. If insomnia became the cause of the treatment, then the drug is drunk at night - 30-60 minutes before the child goes to bed.

The maximum dosage of Persen per day is 12 tablets. The duration of use should be determined by the doctor, but the medication should not be drunk for longer than 2 months. If instead of a tablet medicine, the doctor prescribed the drug in Forte capsules, then they drink it according to the same scheme, but at a dose of 1-2 capsules per dose.

Overdose and drug interactions

A very large dose of Persen provokes the appearance of abdominal cramps, hand tremors, weakness, dizziness and other negative symptoms. To eliminate them, it is recommended to wash the stomach and consult a doctor.

Treatment with Persen may enhance the effect of sleeping pills and any drugs that can depress the central nervous system. In addition, taking pills increases the effectiveness of antihypertensive drugs and painkillers.

Terms of sale and storage

Persen is sold without a prescription and costs an average of 200 rubles for 20 tablets or 350 rubles for 40 tablets. To buy Forte and Night capsules, a prescription is also not required. It is recommended to store the medicine at home at room temperature in a place that will be dry and hidden from children. The shelf life of both Persen tablets and Forte and Persen Night capsules is 3 years.