In this medical article, you can get acquainted with the drug Corvalol. The instructions for use will explain in which cases you can take injections or tablets, what the medicine helps with, what are the indications for use, contraindications and side effects. The annotation presents the form of release of the drug and its composition.
In the article, doctors and consumers can only leave real reviews about Corvalol, from which you can find out if the drug helped in the treatment of neurosis and irritability (sedative or sedative) in adults and children, for which it is also prescribed. The instructions list analogues of Corvalol, drug prices in pharmacies, as well as its use during pregnancy.
An effective drug with a sedative (sedative) effect is Corvalol. Instructions for use prescribes taking tablets, drops or tincture for insomnia and heart disorders.
Release form and composition
The drug Corvalol is available in the form of tablets, drops for oral administration, with a pungent mint smell in dark glass bottles of 25 ml. Instructions are included in the cardboard box.
The composition of the drug includes active active ingredients - phenobarbital, peppermint and ethyl ester of alpha-bromoisovaleric acid. Also, the composition of the drug includes a number of auxiliary components.
1 tablet of Corvalol contains 850 micrograms of peppermint oil, 7.5 mg of phenobarbital and 8.2 mg of α-bromoisovaleric acid ethyl ester.
The composition of drugs from different manufacturers may vary slightly. So, for example, the composition of Corvalol N (not available in tablets, only in the form of oral drops), in addition to these active components, also includes hop oil (concentration - 0.2 mg / ml). Excipients of the drug: sodium acetate trihydrate, diluted acetic acid, purified water, 96% ethanol.
pharmachologic effect
Corvalol is a combination drug. Its sedative and antispasmodic effect is due to the medicinal properties of the constituent substances. The drug has an excellent sedative effect and promotes the onset of natural sleep, therefore it is indicated for nervous disorders and insomnia.
These properties are given to it by the ethyl ester of alpha-bromoisovaleric acid, which is a sedative (its effect is very similar to the sedative effect of valerian) and antispasmodic.
Phenobarbital in the composition of the drug has an active effect on reducing the excitation of the central nervous system and, like the previous component of the drug, contributes to the onset of natural sleep.
Peppermint oil also has a reflex vasodilating and antispasmodic effect. Due to the presence of these substances in the composition of the drug, you should strictly monitor the dose of the drug in order to avoid an overdose of Corvalol.
Indications for use
What helps Corvalol? Tablets are prescribed for the treatment of:
- intestinal spasms caused by neurovegetative disorders;
- neuroses with increased irritability;
- insomnia;
- tachycardia and spasm of the coronary vessels (provided that these conditions are not pronounced);
- VSD and hypertension (used in complex therapy).
Drops, like tablets, are used for disorders of the central nervous system, which are accompanied by increased irritability, in the early stages of the development of hypertension, with neurocirculatory dystonia, insomnia, moderate tachycardia, and also to reduce the symptoms of spasm of the coronary vessels, provided that they are not bright expressed.
Instructions for use
The dose is set individually. Take orally, before meals, drink water. Adults are usually prescribed 1-2 tablets 2 times a day. With tachycardia, a single dose can be increased to 3 tablets. The maximum daily dose is 6 tablets. The duration of the drug is set by the doctor individually.
Drops Corvalol
Designed for oral administration. Previously, a single dose of drops is diluted with a small amount of water (about 20 ml). According to the instructions, a single dose of the drug is 15-25 drops 3 times a day. If necessary, under the supervision of a physician, a single dose of the drug can be increased to 50 drops. For patients aged 12 years, a single dose of the drug should not exceed 15 drops.
The duration of the course of treatment with Corvalol is determined by the doctor on a strictly individual basis.
How many times a day can I take the drug?
When asked how often Corvalol can be drunk, doctors answer that the frequency of applications depends on the indications. In some cases, a single dose of the drug is sufficient, in some tablets / drops should be drunk up to 3 times / day.
The duration of the course is determined depending on the tolerability and therapeutic efficacy of the drug.
Contraindications
According to the instructions, Corvalol should not be prescribed for severe renal, hepatic, during lactation, hypersensitivity. During pregnancy, the drug is used with caution.
During therapy, increased caution should be observed when driving vehicles, operating mechanisms, engaging in activities that require quick reaction, concentration.
Side effects
The negative actions of Corvalol are manifested in the form of: 
- difficulty breathing;
- hypersensitivity reactions (including angioedema);
- skin manifestations of allergies;
- disorders of the nervous system (ataxia, nystagmus, weakness, impaired coordination of movements, slow reactions, fatigue, paradoxical arousal, hallucinations, mild dizziness, cognitive impairment, headaches, drowsiness, confusion, decreased concentration of attention);
- arterial hypotension, bradycardia;
- digestive disorders (heaviness in the epigastric region, constipation; against the background of long-term treatment with the drug, nausea, liver dysfunction, vomiting are possible);
- changes in the blood formula (agranulocytosis, thrombocytopenia, anemia).
With prolonged use of the drug, violations of osteogenesis and the development of manifestations of bromism are possible: CNS depression, ataxia, conjunctivitis, rhinitis, depression, lacrimation, purpura or acne, confusion.
As a rule, these symptoms disappear after a dose reduction or discontinuation of treatment with Corvalol.
Children, during pregnancy and lactation
Contraindicated in pregnancy and during breastfeeding.
The drug is not prescribed to persons under 12 years of age due to the lack of clinical experience and data on the effect of the active ingredients of the drug on the child's body.
special instructions
Since the drug Corvalol has a direct effect on the activity of the central nervous system, the patient during the period of treatment with this drug should refrain from driving and activities that require increased concentration.
During the period of treatment with the drug, you should refrain from drinking alcohol, as alcohol enhances the therapeutic effect of the drug, which can lead to the development of serious side effects.
drug interaction
The action of Corvalol is enhanced with simultaneous use with drugs of the central inhibitory type of action, alcohol, valproic acid preparations.
Phenobarbital, inducing hepatic enzymes, thereby accelerates the metabolism of drugs that are biotransformed in the liver, including: cardiac glycosides, anticoagulants of indirect action; antifungal, antiviral, antimicrobial, antiepileptic, psychotropic, anticonvulsant, hormonal, oral hypoglycemic, cytostatic, immunosuppressive, antihypertensive and antiarrhythmic drugs.
Corvalol enhances the toxic effects of Methotrexate. Potentiates the action of local anesthetics and analgesics.
When using Phenobarbital in combination with gold preparations, the risk of kidney damage increases, with NSAIDs (with prolonged use) - the risk of ulceration of the gastric mucosa and the development of bleeding, with Zidovudine - the toxicity of both drugs increases.
The prolongation of the effects of Phenobarbital is facilitated by the simultaneous use of MAOIs. Reducing their severity - taking Rifampicin.
Corvalol's analogs
The drugs with a sedative effect include analogues:
- Cravaleon.
- Hawthorn tincture.
- Peony tincture.
- Sedative collection.
- Bellataminal.
- Valeodicramen.
- Bromenval.
- Phytorelax.
- Calming collection.
- Landyshevo-motherwort drops.
- Corvaldin.
- Fitosedan.
- Adonis bromine.
- Fertility hops.
- Calm down.
- Hop extract liquid.
- Passifit.
- Fito Novo-Sed.
- Sedoflor.
- Motherwort tincture.
- Novo-Passit.
- Doppelhertz Vitalotonic.
- Landyshevo-valerian drops.
- Klosterfrau MELISANA.
- Valoserdin.
- Valemidin.
- Songa Knight.
- Karniland.
- Sleepex.
- Barboval.
- Doppelhertz Melissa.
- Balm Muscovy.
- Valocordin.
- Valerian tincture.
- Kliofit.
- Lotusonic.
Which is better: Corvalol or Valocordin?
The difference in the composition of Valocordin and Corvalol is very insignificant. The only difference is that the former contains a small amount of hop oil, which has a calming and antispasmodic effect.
When asked how Valocordin differs from Corvalol, doctors answer that the drugs are absolutely identical. Both of them quickly eliminate discomfort and pain in the heart, and with timely use, they can prevent an attack of angina pectoris and myocardial infarction.
Holiday conditions and price
The average cost of Corvalol (25 ml drops) in Moscow is 25 rubles. The price of 20 tablets is 135 rubles. The drug is approved for over-the-counter dispensing from pharmacies.
Keep drops away from children in a cool, dark place. Always close the cap carefully after use. The shelf life is 3 years from the date of production, after the expiration of this period, the drops should not be taken orally.
Corvalol drops are one of the most popular drugs in cardiology. But now manufacturers have begun to produce this remedy in an even more convenient form for taking - in tablets.
Corvalol tablets - description
Corvalol ( tincture or tablets) for oral administration contains a number of active ingredients that provide sedative and antispasmodic effects. The tablet form of release is 0.2 g pills, produced by 10,20,50 pieces per package (blisters of 10 pieces).
The active composition of the drug is represented by the following components:
- phenobarbital- antiepileptic drug, barbiturate;
- peppermint oil- antispasmodic, antiseptic, substance of natural origin;
- ethyl ester of alpha-bromoisovaleric acid- a substance obtained from the root of valerian, antispasmodic, sedative.
To ensure the desired properties, shape and storage conditions, the tablets contain a number of additional substances - talc, magnesium stearate, magnesium aluminometasilicate, lactose monohydrate, starch, betadex. The drug in drops is distinguished by the presence of ethanol and water, as well as a stabilizer. The active composition is the same. Price for 20 tablets usually no more than 130 rubles.
The action of the drug
Phenobarbital- a derivative of barbituric acid, has a non-selective inhibitory effect on the central nervous system (CNS). After administration, it increases the sensitivity of specific GABA receptors to gamma-aminobutyric acid. As a result, the excitability of nerve cells decreases, and a sedative effect is provided.
Phenobarbital is often used as a sleeping pill - it not only helps to calm down, but also eliminates sleep disorders.
The valerian derivative also has a sedative effect (similar to a plant), reduces reflex excitation in the nervous system, and increases the inhibitory power of various processes in the cortex and subcortical substance of the brain.
Through the impact on smooth muscle fibers the substance has an antispasmodic effect, relaxes blood vessels.
Peppermint oil has the following properties:
- moderate bile thinning;
- disinfectant;
- vasodilating;
- antispasmodic.
The oil activates special cold receptors in the oral cavity, which causes the coronary and cerebral vessels to expand and relax. In addition to a positive effect on the cardiovascular system, the oil enhances the work of the intestines, improves the production and movement of bile.
Indications for use
The main indication for use is participation in the complex therapy of various diseases of the heart and blood vessels. Tablets can be drunk as a symptomatic remedy for any condition that is combined with increased irritability. The drug lowers blood pressure, so many patients prefer to take it in conjunction with antihypertensive drugs.
The medicine Corvalol in tablets helps with various functional disorders of the nervous system, heart, blood vessels:< /p>
The drug will also be useful for intestinal spasms - it reduces the manifestations of flatulence, spastic colitis, dyspepsia, neurovegetative disorders of the gastrointestinal tract. Often the drug is recommended for use during a hangover, headache, especially of vascular origin (for example, with hypertension). In most cases, Corvalol is a component of combination therapy; it is rarely used as an independent remedy.
Instructions for use
When treating Corvalol, it is important to prevent overdose. It is better to play it safe, because phenobarbilal in the composition of the drug can be harmful if it enters the body in excess. Tablets are taken sublingually (placed under the tongue). They can also be drunk with water (100-150 ml).
A single dosage of the drug is 1 tablet, but in some cases the doctor may recommend drinking 2-3 tablets / dose.
Standard daily dosage - up to 3 tablets. This dose is indicated for cases that do not involve acute disorders of the heart and blood vessels. The instruction clearly answers how much per day you can take this remedy. The upper limit of the daily dosage for an adult is 6 Corvalol tablets. The duration of the course is selected by the doctor, it depends on the type of disease, the tolerance of Corvalol.
The specific rules for admission are as follows:
Children are prescribed medicine only in emergency cases, the dosage is selected individually (more often it is ? - ? from an adult). For the treatment of nervous disorders, it is preferable to use a special remedy Corvalol Kids.
Pills and traditional medicine
Often, traditional healers are advised to use the drug for herpes on the lips. It is better to start treatment at the first symptoms - itching, twitching, irritation. The easiest way to use Corvalol for this purpose is in the form of a tincture. The recipe is the following:
- moisten a cotton swab in the preparation;
- apply to the problem area on the skin;
- hold for 10-20 seconds, if the herpes has already appeared, then glue the cotton with a band-aid for 5 minutes;
- repeat therapy up to 6 times / day.
If you leave the application on the skin for too long, it may cause a burn. Inside, drinking drops, tablets for herpes does not make sense - they do not have an antiviral effect. Another option for external treatment, according to traditional medicine, is getting rid of acne. The alcohol remedy effectively treats purulent and inflamed rashes, they need to be spotted with a cotton swab up to 5 times / day.
Another recipe involving tincture is a healing mixture with a calming effect. For manufacturing, you need to pour into one bottle of tincture of peony, motherwort, valerian, as well as Corvalol. Store the product in the refrigerator. Drink it 30 drops with 50 ml of water three times / day half an hour before meals. Course - 14 days.
Side effects and contraindications
During pregnancy, it is highly undesirable to take pills; in the 1st trimester, treatment is excluded. Phenobarbital can have a negative effect on the fetus, especially on its nervous system. Without the recommendation of a doctor, even a single dose is not allowed!
Lactation is also a contraindication to therapy - during treatment, you will have to stop breastfeeding.
It is also forbidden to use the drug in the presence of hypersensitivity, intolerance to components, with severe disorders of the kidneys and liver. At the age of 18 years, complete safety for the body after taking Corvalol has not been established, a single dose is carried out under the supervision of a doctor.
Other contraindications:
- malabsorption of glucose, galactose;
- lactase deficiency.
Among the side effects, various disorders of the central nervous system are noted - decreased attentiveness, bradycardia, dizziness, drowsiness, weakness. Some people experience hypersensitivity reactions, allergies. Diarrhea, abdominal pain are possible, which disappear with a decrease in dosage or after the abolition of Corvalol. Long-term treatment is addictive with the appearance of apathy, rash, rhinitis.
Analogues and special instructions
There are a number of drugs with a similar effect. Most of them are prescribed by prescription.
During treatment can't take alcohol! This can lead to various complications.
Alcohol increases the rate of heart rate, and the drug stabilizes it. The resulting imbalance interferes with the normal activity of the heart muscle.
When taking a large dose of alcohol and pills at the same time, the risk of heart damage and even myocardial rupture is high.
When taking tablets, care should be taken when working with mechanisms, while driving - phenobarbital has an inhibitory effect on the central nervous system. Simultaneous treatment reduces the effectiveness of certain drugs (corticosteroids, hormonal contraceptives, coumarin), enhances the work of sleeping pills, analgesics.
0*registered by the Ministry of Health of the Russian Federation (according to grls.rosminzdrav.ru)
Registration number:
LP 003225-290915
Trade name of the drug:
Corvalol
International non-proprietary or grouping name:
Peppermint Leaf Oil + Phenobarbital + Ethyl Bromisovalerianate
Dosage form:
tablets
Composition per tablet:
Active substances: ethyl bromisovalerianate (ethyl ester of alpha-bromoisovaleric acid) - 8.20 mg, phenobarbital - 7.50 mg, peppermint leaf oil (peppermint oil) - 0.58 mg.
Excipients: betadex (beta-cyclodextrin) - 55.55 mg, potato starch - 37.57 mg, lactose monohydrate (milk sugar) - 83.70 mg, magnesium aluminometasilicate (neusilin UFL 2) - 4.00 mg, talc - 2.00 mg, magnesium stearate - 0.90 mg.
Description: Round, flat-cylindrical tablets of white or almost white color, interspersed, chamfered and scored.
Pharmacotherapeutic group:
sedative.
ATX Code: .
Pharmacological properties
Pharmacodynamics
The combined drug has a sedative and antispasmodic effect, facilitates the onset of natural sleep.
Ethylbromisovalerianate has a sedative and antispasmodic effect due to irritation, mainly of the receptors of the oral cavity and nasopharynx, a decrease in reflex excitability in the central parts of the nervous system and an increase in inhibition in the neurons of the cortex and subcortical structures of the brain, as well as a decrease in the activity of the central vasomotor centers and a direct local antispasmodic effect on smooth muscle.
Phenobarbital has a sedative (in small doses), hypnotic, muscle relaxant and antispasmodic effects, helps to reduce the excitation of the central nervous system (CNS) and facilitates the onset of sleep, enhances the sedative effect of other components.
Peppermint oil has a reflex vasodilating, antispasmodic, mild choleretic, antiseptic effect. The mechanism of action is associated with the ability to irritate the "cold" receptors of the oral mucosa and reflexively expand mainly the vessels of the heart and brain. Eliminates the phenomena of flatulence due to irritation of the receptors of the mucous membrane of the gastrointestinal tract (GIT), increasing intestinal motility.
Pharmacokinetics
Data on the pharmacokinetics of ethyl bromisovalerianate and peppermint components are not available.
When taken orally, phenobarbital is absorbed slowly, completely. The maximum concentration in blood plasma is determined after 1-2 hours, the connection with plasma proteins is 50%, in newborns it is 30-40%. Metabolized in the liver, induces microsomal liver enzymes by CYP3A4, CYP3A5, CYP3A7 isoenzymes (the rate of enzymatic reactions increases 10-12 times). accumulates in the body. The half-life is 2-4 days. Excreted by the kidneys in the form of glucuronide, about 25% - unchanged. Penetrates into breast milk and through the placental barrier.
Indications for use
As a symptomatic (sedative and vasodilator) remedy for functional disorders of the cardiovascular system, in neurosis-like conditions accompanied by increased irritability, in violation of falling asleep, tachycardia, a state of excitation with pronounced vegetative manifestations; as an antispasmodic - with spasms of the intestines.
Contraindications
Hypersensitivity to the components of the drug;
- severe impairment of kidney and / or liver function;
- pregnancy;
- the period of breastfeeding;
- children under 18 years of age (efficacy and safety have not been established);
- Lactase deficiency, lactose intolerance, glucose-galactose malabsorption (the product contains lactose).
Carefully
Impaired liver and / or kidney function.
If you have one of the listed diseases/conditions, be sure to consult your doctor before taking the drug.
Use during pregnancy and during breastfeeding
The use of the drug Corvalol during pregnancy and during breastfeeding is contraindicated, since the drug contains phenobarbital, which penetrates the placenta and has a teratogenic effect, has a negative effect on the formation and further functioning of the central nervous system of the fetus and newborn; penetrates into breast milk, the development of physical dependence in the newborn is possible. If necessary, use during breastfeeding should resolve the issue of stopping breastfeeding.
Dosage and administration
Take orally, before meals, drink water.
The dosage is set individually.
Adults are usually prescribed 1-2 tablets 2 times a day. With tachycardia, it is possible to increase a single dose to 3 tablets.
The duration of the drug is set by the doctor individually.
Side effect
Drowsiness, dizziness, slow heart rate, reduced ability to concentrate, allergic reactions. Gastrointestinal disorders may occur. These phenomena disappear with a decrease in the dose of the drug or discontinuation of the drug.
With prolonged use of the drug, drug dependence, addiction, "withdrawal" syndrome may occur, as well as the accumulation of bromine in the body and the development of bromism phenomena (depressive mood, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements).
If any of the side effects listed in the instructions get worse, or if you notice any other side effects not listed in the instructions, tell your doctor.
Overdose
Symptoms: depression of the central nervous system (CNS), nystagmus, ataxia, lowering blood pressure, agitation, dizziness, weakness, chronic bromine intoxication (depression, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements).
Treatment: discontinuation of the drug, gastric lavage and symptomatic therapy, with CNS depression - caffeine, nikethamide.
Interaction with other drugs
Drugs that depress the central nervous system enhance the effect of the drug. Phenobarbital (an inducer of microsomal oxidation) may reduce the effectiveness of drugs metabolized in the liver (including coumarin derivatives, griseofulvin, glucocorticosteroids, oral contraceptives); enhances the action of local anesthetics, analgesics and hypnotics.
The drug enhances the toxicity of methotrexate.
The effect of the drug is enhanced by the use of valproic acid preparations.
special instructions
There is no experience of using the drug in children under 18 years of age.
During the use of the drug should not drink alcohol.
Influence on the ability to drive vehicles and mechanisms
The drug contains phenobarbital, so patients taking Corvalol are advised to refrain from engaging in potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions (including driving and working with complex mechanisms).
Release form
Tablets.
10 tablets in a blister pack made of PVC film and printed lacquered aluminum foil.
1, 2, 3, 4 or 5 contour packs, together with instructions for use, are placed in a cardboard pack.
Storage conditions
Store the drug in its original packaging. At a temperature not higher than 25 °C.
Keep out of the reach of children!
Best before date
1 year 6 months. Do not use after the expiration date.
Holiday conditions
Released without a prescription.
Name and address of manufacturer/organization receiving claims
JSC Pharmstandard-Leksrsdstva.
305022, Russia, Kursk, st. 2nd Aggregate, 1 a/18,
www.pharmstd.ru
Elderly people often suffer from pain in the heart. With an appropriate diagnosis, the doctor may prescribe Corvalol to the patient. This medicine is also used for chest tightness, anxiety or insomnia. Like any medication, Corvalol has side effects and contraindications, so you should consult with your doctor before taking the medicine.
Corvalol (lat. Korvalol) is used for diseases of the cardiovascular system. It corrects functional deviations in the work of an important organ, gives calmness and helps to improve the general condition of the patient.
There are several forms of drug release:
Corvalol is dispensed from pharmacies without a doctor's prescription. The drug should be stored in a dark room at a temperature of +16 ... +26 degrees. It must not be accessed by children or pets. The shelf life of the drug is 2.5 years from the date of production. After this time, it is forbidden to take the medicine.
The drug has many analogues that have a similar sedative effect. For example, Corvalol drops can be replaced with Valocordin (the product is made in Germany). Analogues of the drug, consisting entirely of natural ingredients, - Novo-Passit. Barboval, Adonis-bromine and motherwort tincture - they all also belong to the pharmacological group of sedatives.
It must be remembered that it is possible to replace the medicine only after consulting with the treating specialist.
Impact on the human body
Corvalol lowers blood pressure and has a stimulating effect on the vasomotor centers. This helps to relieve and prevent spasms of the heart and other vessels. The soothing properties of the drug are explained by the presence of certain components in it:
After ingestion, the drug immediately begins to be absorbed in the oral cavity. The active ingredients are highly bioavailable. It varies between 60-80%. If you keep the tablet in the mouth longer or take drops with a piece of refined sugar, you can expect a faster effect from the drug.
The drug begins to act after 20-40 minutes, and the effect of it lasts up to 3-6 hours. The duration of action may be reduced if the patient has previously taken drugs with barbituric acid.
In people with cirrhosis of the liver and elderly patients, a reduced metabolism is observed - they need to increase the interval between medications and reduce the dose.
Indications for admission
Any medicines for the treatment of cardiovascular diseases should be prescribed only by a specialist. He can tell you what Corvalol drops and the tablet form of the drug help with, and whether they can be taken in each case.
As a sedative and vasodilator, the drug is used for certain pathologies. The doctor prescribes treatment with this medicine only after examining the patient and making a diagnosis.
Indications for Corvalol's use:
- vegetative lability;
- hypochondriacal syndrome;
- irritability;
- sinus tachycardia;
- cardialgia;
- blood pressure disorders.
Carvalol can be used by patients suffering from neurosis-like conditions. These can be sleep disturbances due to acute or chronic stress. However, in these cases, the drug can not be used for a long time: after two weeks of use, the effect of it decreases.
The medicine can also be used if the patient has spasms of the muscles of the digestive system. Antispasmodic helps to cope with biliary and intestinal colic.
Instructions for use
The doctor prescribes Corvalol to patients in whom cardiac disorders have arisen due to neurosis. The specialist must also make sure that the patient does not have serious pathologies from the heart. If you do not start treating arrhythmia, angina pectoris or other serious illness in a timely manner, then the medication can adversely affect the person's condition.
Dosage and method of application of Corvalol:
The medication should be taken within two weeks. Some patients use Corvalol longer, but its effect gradually decreases. Elderly people may increase the duration of treatment.
Overdose and side effects
Corvalol should be taken according to the scheme prescribed by the doctor. An overdose of the drug can lead to a hypnotic effect. This is due to the cumulation of the components in the composition of the drug. If the patient takes Corvalol for a long time, then the medication will cause dependence and psychomotor agitation. Withdrawal syndrome is possible if you abruptly stop taking the drug.
Signs of an overdose:
In the case when the patient has an acute overdose, doctors need to maintain the vital functions of his body. In this case, conduct detoxification therapy. Sometimes resuscitation may be required.
Usually patients tolerate Corvalol well. Side effects are rare. Possible negative effects can be observed from several body systems:
Liver failure, fever, and conjunctivitis may also occur. Due to the action of phenobarbital, megaloblastic anemia sometimes develops.
If there was a dosage of Corvalol, the victim must be given first aid and eliminate signs of poisoning. It is necessary to wash the stomach by giving several glasses of water with a sorbent to drink (Smecta, Filtrum, activated charcoal). You can press on the root of the tongue to induce a gag reflex. In case of convulsions or coma, an ambulance should be called urgently.
Contraindications for use
Corvalol helps to cope with various pathologies of the cardiovascular system. But this medicine can adversely affect the patient's condition if he does not tolerate the components contained in the drug.
Corvalol is contraindicated in the following cases:
With caution, you should take the drug for stomach or duodenal ulcers.
Corvalol should not be taken by pregnant women, since phenobarbital adversely affects the condition of the fetus. The substance has a depressing effect on the nervous system of the child and the expectant mother. The drug component can cause bleeding in the first days of the baby's life. If a woman takes Corvalol in the third trimester of pregnancy, she may develop addiction and subsequent withdrawal syndrome, and the baby may develop convulsions and severe excitability.
The drug should also not be used by women during lactation. If Corvalol cannot be dispensed with, then the patient must stop breastfeeding.
For patients who have depressive disorders, suicidal tendencies or drug addiction, the doctor should prescribe another medicine.
In the elderly and immunocompromised patients, reactions to phenobarbital may occur in the form of confusion or severe motor restlessness. With great care, Corvalol is prescribed to people with acute or chronic pain: due to the drug, paradoxical excitation may occur, which masks important clinical symptoms. If the medication is prescribed to a patient with arterial hypotension, then the doctor must constantly monitor the patient's condition.
Interaction with other drugs
Drugs of the central depressant type enhance the effect of the sedative. Corvalol should not be used in combination with drugs that are metabolized in the liver. The phenobarbital contained in Corvalol induces the enzymes of this organ and reduces the effectiveness of the drugs.
The medicine can increase the effect of sleeping pills, painkillers and local anesthetic medicines. Corvalol should not be taken with valproic acid and methotrexate. During treatment with the drug, it is necessary to abandon alcoholic beverages, which increase its toxicity.
Features of the action of the drug
Corvalol can disrupt coordination and reduce the speed of psychomotor reactions. Therefore, people taking this drug should not drive or operate machinery. At the time of therapy, you should also abandon any activity associated with increased concentration.
Some consider Corvalol a remedy for most ailments. The medicine helps to get rid of a neurotic state and normalize sleep. If you correctly follow the scheme of taking the medicine prescribed by the doctor, it will be possible to avoid negative consequences.
Last update of the description by the manufacturer 17.06.2009
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Active substance:
ATX
Pharmacological group
Nosological classification (ICD-10)
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Composition and form of release
in dark glass dropper bottles of 15 or 25 ml; in a cardboard pack 1 dropper bottle.
Description of the dosage form
Transparent colorless liquid with a fragrant specific smell.
Characteristic
Combined drug.
pharmachologic effect
pharmachologic effect- antispasmodic, vasodilating, sedative.Pharmacodynamics
Phenobarbital has a sedative and mild hypnotic effect. It helps to reduce the excitation of the central nervous system and facilitates the onset of natural sleep. Ethylbromisovalerianate has a sedative and antispasmodic effect. Peppermint oil has reflex vasodilating and antispasmodic activity.
Indications for Corvalol
As a sedative and vasodilator:
functional disorders of the cardiovascular system;
neurosis-like states, accompanied by increased irritability;
sleep disorders;
tachycardia;
states of excitation with pronounced vegetative manifestations.
As an antispasmodic:
spasms of the intestines.
Contraindications
hypersensitivity to the components of the drug;
severe impairment of kidney and / or liver function.
The appointment of the drug during pregnancy is possible only according to strict indications. If it is necessary to prescribe the drug during breastfeeding, the issue of stopping breastfeeding should be resolved.
Side effects
Corvalol is generally well tolerated. In some cases, drowsiness and slight dizziness may occur during the daytime.
With prolonged use of large doses, the development of chronic bromine poisoning is possible, the manifestations of which are: depressive mood, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination.
Dosage and administration
inside. The dosage is set individually. Adults are usually prescribed 15-30 drops 3 times a day before meals. With tachycardia, it is possible to increase a single dose to 40-50 drops. Children are prescribed 3-15 drops per day, depending on the age and clinical picture of the disease.
The duration of the drug is set individually by the doctor.
special instructions
The drug contains 79 volume percent ethanol and phenobarbital, so patients taking Corvalol are not recommended to engage in activities associated with increased attention and requiring quick mental and motor reactions.
With prolonged use of the drug, the formation of drug dependence is possible; possible accumulation of bromine in the body and the development of poisoning them.
If you experience any side (unusual) effects, you should report them to your doctor.
Storage conditions of the drug Corvalol
At a temperature not higher than 25 °C.Keep out of the reach of children.
Shelf life of Corvalol
5 years.Do not use after the expiry date stated on the packaging.
Instructions for medical use
Corvalol
Instructions for medical use - RU No. LP-003881
Last Modified Date: 05.10.2016
Dosage form
Tablets.
Compound
Composition per tablet:
Active substances:
Ethyl bromisovalerianate - 8.2 mg
(alpha-bromoisovaleric acid ethyl ester)
Phenobarbital - 7.5 mg
Peppermint leaf oil - 0.58 mg
Excipients:
β-cyclodextrin - 55.55 mg
Potato starch - 13.00 mg
Lactose monohydrate - 43.77 mg
Cellulose microcrystalline - 10.50 mg
Magnesium stearate - 0.90 mg
Description of the dosage form
Tablets of white or almost white color with inclusions, round shape with a flat surface, beveled to the edge with chamfers.
Pharmacological group
Sedative.
Pharmacodynamics
The combined drug has a sedative and antispasmodic effect, facilitates the onset of natural sleep.
Ethyl bromisovalerianate (ethyl ester of alpha-bromoisovaleric acid) has a sedative (similar to the effect of valerian) and antispasmodic effect due to irritation, mainly of the receptors of the oral cavity and nasopharynx, a decrease in reflex excitability in the central parts of the nervous system and increased inhibition in the neurons of the cortex and subcortical structures of the brain, as well as a decrease in the activity of the central vasomotor centers and a direct local antispasmodic effect on smooth muscles.
Phenobarbital has a sedative (in small doses), hypnotic, muscle relaxant and antispasmodic effects, helps to reduce the excitation of the central nervous system (CNS) and facilitates the onset of sleep, enhances the sedative effect of other components.
Peppermint leaf oil has a reflex vasodilatory effect. antispasmodic, mild choleretic, antiseptic action. The mechanism of action is associated with the ability to irritate the "cold" receptors of the oral mucosa and reflexively expand mainly the vessels of the heart and brain. Eliminates the phenomena of flatulence due to irritation of the receptors of the mucous membrane of the gastrointestinal tract (GIT). enhancing intestinal peristalsis.
Pharmacokinetics
Data on the pharmacokinetics of ethyl bromisovalerianate and peppermint components are not available. When taken orally, phenobarbital is absorbed slowly, completely. The maximum concentration in blood plasma is determined after 1-2 hours. The connection with plasma proteins is 50%, in newborns - 30-40%. Metabolized in the liver, induces microsomal liver enzymes by CYP3A4, CYP3A5, CYP3A7 isoenzymes (the rate of enzymatic reactions increases 10-12 times). accumulates in the body. The half-life is 2-4 days. It is excreted by the kidneys in the form of glucuronide, about 25% unchanged. Penetrates into breast milk and through the placental barrier.
Indications
Corvalol is prescribed as a symptomatic (calming and vasodilating) agent for functional disorders of the cardiovascular system. with neurosis-like states, accompanied by increased irritability, sleep disturbance, tachycardia, a state of excitation with pronounced vegetative manifestations; as an antispasmodic for intestinal spasms.
Contraindications
- Hypersensitivity to the components of the drug;
- Severe impairment of kidney and / or liver function;
- Pregnancy;
- The period of breastfeeding;
- Children under 18 years of age (efficacy and safety have not been established);
- Lactase deficiency, lactose intolerance, glucose-galactose malabsorption (the product contains lactose).
Carefully
Impaired kidney and / or liver function.
If you have one of the listed diseases/conditions, be sure to consult your doctor before taking the drug.
Use during pregnancy and lactation
The use of Corvalol during pregnancy and during breastfeeding is contraindicated, since the drug contains phenobarbital, which crosses the placenta and has a teratogenic effect, has a negative effect on the formation and further functioning of the central nervous system of the fetus and newborn; penetrates into breast milk, the development of physical dependence in the newborn is possible. If it is necessary to use the drug during breastfeeding, the issue of stopping breastfeeding with breast milk should be resolved.
Dosage and administration
For oral administration, before taking, write with water.
Adults are usually prescribed 1-2 tablets of the drug 2 times a day.
With tachycardia, it is possible to increase a single dose to 3 tablets.
The maximum daily dose is 6 tablets.
The dosage and duration of treatment is set by the doctor individually for each patient.
Side effects
Corvalol is generally well tolerated. In some cases, drowsiness, slight dizziness, slowing of the heart rate, decreased ability to concentrate, and an allergic reaction may occur. Gastrointestinal disorders may occur. These phenomena disappear with a decrease in the dose of the drug or discontinuation of the drug.
With prolonged use of the drug, the formation of drug dependence, addiction, the "withdrawal" syndrome, as well as the accumulation of bromine in the body and the development of bromine phenomena (depressive mood, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements) are possible.
If any of the side effects listed in the instructions get worse, or if you notice any other side effects not listed in the instructions, tell your doctor.
Overdose
Symptoms: depression of the central nervous system, nystagmus, ataxia, lowering blood pressure, agitation, dizziness, weakness, chronic bromine intoxication (depression, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements).
Treatment: discontinuation of the drug, gastric lavage and symptomatic therapy, with CNS depression - caffeine, nikethamide.
Interaction
Medicines that depress the central nervous system enhance the effect of the drug.
Phenobarbital (an inducer of microsomal oxidation) may reduce the effectiveness of drugs metabolized in the liver (including coumarin derivatives, griseofulvin, glucocorticosteroids, oral contraceptives); enhances the action of local anesthetic, analgesic and hypnotic drugs.
The drug enhances the toxicity of methotrexate.
The action of the drug is enhanced by the use of valproic acid preparations.
special instructions
There is no experience of using the drug in children under 18 years of age.
During the use of the drug should not drink alcohol.
Influence on the ability to drive vehicles, mechanisms.
The drug contains phenobarbital, so patients taking Corvalol should refrain from driving and engaging in other potentially hazardous activities that require increased concentration and psychomotor speed.
Release form
Tablets.
10, 20 or 25 tablets in a blister pack (blister) made of PVC film and printed lacquered aluminum foil.
1, 2, 3, 4, 5 or 10 blisters, together with instructions for medical use, are placed in a cardboard pack.
30, 50, 100 blisters, together with an equal number of instructions for medical use, are placed in a cardboard box (for hospitals).
Storage conditions
In a place protected from light, at a temperature not exceeding 25 ° C.
Keep out of the reach of children.
Best before date
2 years. Do not use after the expiration date.
Terms of dispensing from pharmacies
Without recipe.
LS-002249 from 2015-01-13
Corvalol - instructions for medical use - RU No. LP-003881 dated 2016-10-05
Corvalol - instructions for medical use - RU No. P N001855 / 01 dated 2013-11-25
Corvalol - instructions for medical use - RU No. LP-002745 dated 2015-05-26
Corvalol - instructions for medical use - RU No. P N000123 / 01 dated 2007-07-12
Corvalol - instructions for medical use - RU No. R N000444/01 dated 2012-11-20
Corvalol - instructions for medical use - RU No. LSR-001750/09 dated 2017-06-30
Corvalol - instructions for medical use - RU No. P N000426 / 01 dated 2012-04-25
Corvalol - instructions for medical use - RU No. P N002085/01 dated 2012-09-11
Synonyms of nosological groups
| Category ICD-10 | Synonyms of diseases according to ICD-10 |
|---|---|
| F48.9 Neurotic disorder, unspecified | Secondary neurotic symptom |
| Other neurotic conditions | |
| Neurosis | |
| neuroses | |
| Neurosis of all kinds | |
| neuroses with retardation | |
| Neuroses of the heart | |
| Neurotic disorders in alcoholism | |
| Neurotic disorders with lethargy | |
| Neurotic disorders with anxiety syndrome | |
| Neurotic reactions | |
| Neurotic symptoms in alcoholism | |
| neurotic states | |
| neurotic syndrome | |
| neurotic disorder | |
| An attack of neurological dysfunction | |
| school neurosis | |
| emotional stress | |
| G47.0 Disorders of initiation and maintenance of sleep [insomnia] | Insomnia |
| Insomnia, especially difficulty falling asleep | |
| Desynchronosis | |
| Long-term sleep disturbance | |
| Difficulty falling asleep | |
| Difficulty falling asleep | |
| Difficulty falling asleep | |
| insomnia | |
| Short-term and transient sleep disorders | |
| Short-term and chronic sleep disorders | |
| Short-term or shallow sleep | |
| Sleep disturbance | |
| Sleep disturbance, especially during the falling asleep phase | |
| Sleep disorders | |
| Sleep disorders | |
| Neurotic sleep disorder | |
| shallow superficial sleep | |
| light sleep | |
| Poor sleep quality | |
| Night awakening | |
| Night awakenings | |
| Sleep pathology | |
| Postsomnic disorder | |
| transient insomnia | |
| Sleep problems | |
| early awakening | |
| early morning awakening | |
| early awakenings | |
| Sleep disorder | |
| sleep disorder | |
| Persistent insomnia | |
| Difficulty falling asleep | |
| Difficulty falling asleep | |
| Difficulty falling asleep in children | |
| Difficulty falling asleep | |
| Difficulty falling asleep | |
| Persistent insomnia | |
| Sleep deterioration | |
| chronic insomnia | |
| Frequent nocturnal and/or early morning awakenings | |
| Frequent nocturnal awakenings and feeling of light sleep | |
| I99 Other and unspecified disorders of the circulatory system | Angiopathy |
| Arterial angiopathy | |
| Atherosclerotic angiopathy | |
| Age related vascular disease | |
| Hemodynamic defects of the right half of the heart | |
| Hemodynamic defect of the right half of the heart | |
| Ischemic angiopathy | |
| Violation of arterial circulation | |
| Circulatory disorders | |
| Violation of microcirculation in organs and tissues | |
| Peripheral circulation disorders | |
| Peripheral circulatory disorders in the extremities | |
| Circulatory failure | |
| Occlusive hemodynamic disorder of arteriovenous origin | |
| Acute circulatory failure | |
| Pseudo-angina conditions | |
| Pseudoangina disorder | |
| Circulatory disorder | |
| Thrombus risk | |
| Cardiovascular diseases | |
| Vascular insufficiency | |
| Thrombosis of the arteriovenous shunt | |
| Thrombosis in prosthetic heart valves | |
| Poor circulation in the pelvic organs | |
| Functional insufficiency of the cardiovascular system | |
| Functional disorders of the cardiovascular system | |
| Chronic arterial insufficiency | |
| Chronic circulatory failure | |
| R00.0 Tachycardia, unspecified | Tachycardia |
| R45.1 Restlessness and agitation | Agitation |
| Anxiety | |
| Explosive excitability | |
| Internal arousal | |
| Excitability | |
| Excitation | |
| Acute excitation | |
| Excitation psychomotor | |
| hyperexcitability | |
| motor excitation | |
| Relief of psychomotor agitation | |
| Nervous excitement | |
| restlessness | |
| night restlessness | |
| Acute stage of schizophrenia with arousal | |
| Acute mental agitation | |
| Paroxysm of arousal | |
| overexcitation | |
| Hyperexcitability | |
| Increased nervous excitability | |
| Increased emotional and cardiac excitability | |
| Increased arousal | |
| Mental arousal | |
| Psychomotor agitation | |
| Psychomotor agitation | |
| psychomotor agitation | |
| Psychomotor agitation in psychosis | |
| Psychomotor agitation of an epileptic nature | |
| Psychomotor paroxysm | |
| psychomotor seizure | |
| Symptoms of arousal | |
| Symptoms of psychomotor agitation | |
| state of agitation | |
| state of anxiety | |
| State of arousal | |
| A state of heightened anxiety | |
| State of psychomotor agitation | |
| Anxiety states | |
| Excitation states | |
| Anxiety states in somatic diseases | |
| State of excitation | |
| Feeling restless | |
| Emotional arousal | |
| R45.4 Irritability and anger | outbursts of anger |
| Anger | |
| Dysphoria | |
| Neurosis with increased irritability | |
| Anger | |
| Increased irritability | |
| Increased irritability of the nervous system | |
| Irritability | |
| Irritability in neurosis | |
| Irritability in psychopathic disorders | |
| Symptoms of irritability |
