Antifungal agent "nystatin", suppositories - reviews, instructions for use and composition. Nystatin suppositories: instructions Nystatin suppositories 500 instructions for use

Nystatin - suppositories, the instructions for use for this dosage form provide some features of use and describe in detail the cases in which the medicine will be really useful. Suppositories with Nystatin for thrush are a popular and common remedy prescribed by gynecologists and proctologists to suppress the activity of yeast-like fungi, the activity of which in the human body leads to the development of candidiasis.

Candidiasis is a pathological process that leads to negative symptoms caused by the presence of a mycotic infection. A conditionally pathogenic fungus of the genus Candida, under the influence of endogenous and exogenous factors, turns into a pathogenic one in the body and leads to the development of inflammatory processes that spread to the mucous membranes and skin of a person.

The active active ingredient of suppositories, nystatin, has significant activity against fungal infections, and is available in various dosage forms, including suppositories for rectal and vaginal use.

Medicinal composition, release form

In modern medicine, several dosage forms are used with the active active substance nystatin, the dosage of which can be 250 or 500 thousand units. depending on the packaging of suppositories or other type of drug. The dosage form contains a certain amount of excipients: petroleum jelly, butyloxyanisole, citric acid, butyloxytoluene, semi-synthetic glycerides, which is due to the specifics and localization of the use of the antifungal agent.

When asked whether Nystatin is an antibiotic or not, the attending physician usually characterizes the active ingredient of the suppositories as a polyene antibiotic. The group to which it belongs has a targeted effect, mycocidal and protocidal, which allows it to successfully inhibit the activity of the fungus due to its ability to destroy the cell membranes of mycoses.

You can purchase the suppository in a cardboard box with attached instructions for use and contour blisters, which usually contain 5 suppositories. There are 2 packages in a pack, the blister can be polyethylene or polyvinyl chloride.

Pharmacological action

Nystatin does not show activity against bacterial infections, like other polyene antibiotics. Its main effect is antifungal, achieved due to specific features that are realized during the release of nystatin. Once on the mucous membrane, the active substance penetrates the infectious agent, simultaneously:

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disrupting the permeability of cell membranes;
using double bonds of its own structure for tropism (incorporation into the membrane and formation of a channel for intracellular electrolyte transport);
destructuring the cell by increasing osmolarity;
lysing the cell, which becomes unstable and dies.

In gynecological and proctological practice, it is positioned as a polyene antibiotic with pronounced antifungal, antiseptic and antimicrobial properties, with predominant activity against candidiasis, a fungistatic agent, with little activity against bacterial infections.

Contraindications

The main contraindications are pregnancy and lactation. During lactation, due to the insignificant ability to be absorbed into the blood and the lack of information about excretion from the body in breast milk, Nystatin vaginal suppositories can only be used if breastfeeding is stopped for the period of use of the drug. Some sources indicate pancreatitis, gastric and duodenal ulcers, and liver failure as contraindications. It is definitely not used in the presence of individual immunity to individual components of the drug or the active substance.

Relative contraindications are the presence of vaginal or anal discharge of unknown etiology, hemorrhoids in the acute stage, suspected rectal cancer.

Nystatin suppositories: instructions for use

The instructions included with any dosage form contain detailed instructions on how to take Nystatin to achieve maximum therapeutic effect. Depending on the use in proctological or gynecological practice, different Nystatin suppositories are prescribed, for which suppositories are used rectally or intravaginally, by deep administration. The duration of the course is usually 14 days, but can be increased to achieve therapeutic goals, or recommended again after a break, if necessary.

For thrush

One of the most common prescriptions in gynecological practice is Nystatin suppositories for thrush. Reviews about the effectiveness of the action are received already on the 3-4th day, but the duration of twice daily dosing is always determined at 2 weeks. Typically, the use of suppositories is recommended for both sexual partners to destroy the source of infection. If necessary, the daily therapeutic dose can be increased up to 3-4 times.

For gynecology

Nystatin vaginal suppositories are used; indications for use include the absence of petroleum jelly in the composition. In obstetrics and gynecology, it is prescribed as a remedy against thrush, a way to prevent the occurrence of candidiasis after surgery and the treatment of bacterial infections. Both types of Nystatin suppositories can be used, the indications of which will provide a simultaneous therapeutic and preventive effect when there is a threat of the spread of a fungal infection from the vagina.

During pregnancy

During pregnancy, other medications are recommended for use. Nystatin is used in rare cases during pregnancy, provided that the hypothetical benefit exceeds the expected harm. Clinical studies have not revealed a teratogenic effect of Nystatin, but despite this, in the question of Pimafucin or Nystatin, which is better, in this period preference for use is given to Pimafucin, as it is less harmless.

Nystatin suppositories: side effects

Side effects (rarely) may include itching, redness, rashes, burning, subjective sensations such as the feeling of a foreign body in the anus or the urge to defecate (when used rectally).

Overdose

Cases of overdose with rectal and vaginal suppositories have not been recorded.

Compatibility of suppositories with other medications

Suppositories with Nystatin significantly reduce the activity of Clotrimazole, so it is not recommended to use them at the same time. At the same time, douching significantly neutralizes the therapeutic effect of suppositories.

Nystatin suppositories: analogues

Industrial analogs of Nystatin suppositories are vaginal suppositories: Pimafucin, Moronal, Nystafungin, Fungicidin and Terzhinan, which contain another active substance, but achieve a similar therapeutic effect when used.

How to store candles, terms of sale

Sold in a pharmacy, with a doctor's prescription. Store in a cool, dark place with a storage temperature no higher than 100C, out of the reach of children and direct sunlight. Shelf life: 24 months; after the expiration date indicated on the package, use is not recommended.

Nystatin suppositories: price

The price of the drug may vary depending on the region of residence, dosage, and markup applied in a particular retail pharmacy network. In Moscow it starts from 45 rubles, but in other regions it may be lower.

Nystatin suppositories: reviews

There is a persistent and stable effect of using the drug against candidiasis of the vagina and anus with lesions of any severity by fungi of the genus Candida, better known under the collective collective name thrush. Suppositories also give excellent results when used prophylactically to prevent negative consequences that occur from long-term drug therapy with antibacterial drugs and antibiotics of other groups.

Therapy with the active substance of a suppository for candidiasis that occurs in the form of lesions of the colon mucosa also receives favorable reviews. Practicing surgeons approve of the activity of the dosage form in the prevention of candidiasis, which often occurs after surgical interventions performed on the colon.

Nystatin is a medicinal antifungal drug that has a fungistatic effect. Available in the form of tablets (250,000 and 500,000 units), vaginal and rectal suppositories, and ointments.

Pharmacological action of Nystatin

According to the instructions, the active ingredient of the drug is nystatin.

Excipients of the tablets are emulsion KE-10, titanium dioxide pigment, vanillin, Tween 80, methylcellulose, stearin, medical talc, stearic acid, milk sugar, potato starch.

An auxiliary component of Nystatin suppositories is a fat base. The ointment contains excipients such as medical petroleum jelly and anhydrous lanolin.

According to the instructions, Nystatin is a polyene group antibiotic produced by the actinomycete Streptomyces noursei.

The components of the drug bind to stearins in the cell membranes of fungi, which leads to their inability to function as a selective barrier, and this causes the loss of their main cellular components.

The action of Nystatin is aimed at defeating pathogens of mold mycoses, sporotrichosis, chromomycosis, blastomycosis (deep and visceral), and dermatomycosis. The drug is effective against some pathogenic protozoa.

When used, Nystatin affects the yeast-like fungi Candida and Aspergillus. The medicine blunts the development of vegetative forms of dysenteric amoebae in the intestines.

Nystatin has been noted to be highly effective for thrush.

In accordance with the instructions, Nystatin in all forms of release is not active against viruses, actinomycetes and bacteria.

When used locally and externally, the drug is not absorbed through the mucous membranes and skin. When administered internally, Nystatin is poorly absorbed from the gastrointestinal tract. It is excreted unchanged from the body along with feces.

Indications for use of Nystatin

Nystatin is prescribed for the prevention and treatment of fungal diseases of internal organs, mucous membranes, skin, and gastrointestinal tract, which are caused by yeast-like fungi of the genus Candida. These include candidiasis of the skin, mucous membranes and internal organs, candidiasis of the oral cavity and vagina.

Nystatin is prescribed for thrush, as well as for the purpose of preventing the development of candidiasis while taking high doses of antibiotics (especially tetracyclines) to young children, debilitated patients and the elderly.

Methods of using Nystatin and dosage

Adults should take Nystatin tablets 500,000 units 3-4 times a day or 250,000 6-8 times a day; for the treatment of severe candidiasis of internal organs and candidosepsis - 500,000 units 6-8 times a day. For children, the dosage of Nystatin tablets depends on the age of the child: up to 1 year, ¼ tablet of 250,000 units is prescribed, 1-3 years - 1 tablet. 250,000 units, from 3 years – 250,000-400,000 units. The frequency of taking tablets for children is 3 times a day.

Nystatin ointment for mycoses of the mucous membranes, skin dermatitis and fungal complications that arise when taking antibiotics is applied to the affected surfaces 2 times a day until the symptoms of the disease completely disappear.

For thrush, Nystatin is prescribed in the form of suppositories. Nystatin suppositories are also recommended for the treatment of candidiasis of the lower intestines, vulvovaginitis and colpitis. Rectally, 1 suppository is injected deep into the rectum 1-2 times a day. Use 1 Nystatin suppository intravaginally 2 times a day.

The duration of the course of use of Nystatin is 10-14 days.

A combination of local treatment with oral Nystatin is effective.

Side effects of Nystatin

Nystatin in all forms of release can cause the development of adverse reactions in the form of allergies, accompanied by rashes, itching, skin hyperemia, and urticaria.

When using Nystatin suppositories, vaginal irritation is possible; when taking Nystatin tablets, a bitter taste in the mouth, nausea, abdominal pain, vomiting, and diarrhea may occur.

Contraindications to the use of Nystatin

The medicine is not prescribed to patients with hypersensitivity to its components, liver dysfunction, peptic ulcers of the stomach and duodenum, pancreatitis.

According to the instructions for Nystatin, the drug can be used during pregnancy and lactation.

Overdose

According to reviews, overdose may increase side effects.

Additional information

During Nystatin therapy for thrush, you should abstain from sexual intercourse. Joint treatment of both sexual partners is also recommended.

In accordance with the instructions, Nystatin should be stored in a cool, dark place out of reach of children.

Nystatin is available from pharmacies by prescription.

Shelf life – 24 months.

Nystatin: instructions for use and reviews

Latin name: Nystatin

ATX code: A07AA02

Active ingredient: nystatin

Manufacturer: Biokhimik (Russia), Biosynthesis, JSC (Russia), Irbit Chemical Pharmaceutical Plant (Russia), NIZHFARM (Russia), Borisov Medical Preparations Plant (Republic of Belarus)

Updating the description and photo: 14.08.2019

Nystatin is an antifungal antibiotic drug.

Release form and composition

Nystatin is available in the following dosage forms:

Tablets, coated or film coated: light yellow with a greenish tint, with a slight odor of vanillin, on the cross section - two layers (20 pieces in dark glass jars, plastic containers or polyethylene bottles, 1 jar, container or bottle in cardboard pack; 10, 20 pieces in blister packs, 1-3, 5 packs in a cardboard pack);
Suppositories for rectal use: yellow, torpedo-shaped, with a maximum diameter of 1.2 cm (5 pieces in blister packs, 2 packs in a cardboard box);
Vaginal suppositories: yellow, torpedo-shaped (5 pcs. in blister packs, 2 packs in a cardboard box);
Ointment for external use: brownish-yellow or yellow in color (10, 15, 25 or 30 g in aluminum or polymer tubes, 1 tube in a cardboard box).

1 tablet contains:

Auxiliary components: milk sugar, liquid paraffin, basic magnesium carbonate, hydroxypropyl methylcellulose (OPMC), calcium stearate, potato starch, MC-16 (methylcellulose), titanium dioxide pigment, trolein O, Tween 80, vanillin.

1 rectal suppository includes:

Active ingredient: nystatin – 250,000 or 500,000 units (units of action);
Auxiliary components: propyl ester of parahydroxybenzoic acid, food grade citric acid, vaseline oil, Witepsol W-35, Witepsol H-15.

1 vaginal suppository includes:

Active ingredient: nystatin – 250,000 or 500,000 units (units of action);
Auxiliary components: propyl ester of parahydroxybenzoic acid, food grade citric acid, Witepsol W-35, Witepsol N-15.

The composition of 1 g of external ointment includes:

Active ingredient: nystatin – 100,000 units;
Auxiliary components: anhydrous lanolin, medical petroleum jelly.

Pharmacological properties

Pharmacodynamics

Nystatin is a polyene antifungal antibiotic with antifungal (fungicidal and fungistatic) activity. The structure of the drug contains a large number of double bonds, which determines its high affinity for sterol formations of the cytoplasmic membrane of fungi. In this case, the active substance molecule is integrated into the cell membrane with the formation of a large number of channels that provide uncontrolled transport of water, non-electrolytes and electrolytes. Under the influence of this mechanism, the cell is lysed due to loss of resistance to the influence of external osmotic forces. Resistance to the drug develops very slowly.

Nystatin is active against aspergillus and yeast-like fungi Candida. It has a fungistatic and fungicidal (in large doses) effect. Tolerance of sensitive fungi to nystatin develops very slowly.

Pharmacokinetics

Nystatin, a 19-mycosaminyl nystatinolide, is an antibiotic of the polyene group and is produced by the actinomycete Streptomyces noursei.

It is poorly absorbed from the gastrointestinal tract. The bulk of the drug taken orally is excreted in the feces. Does not exhibit cumulative properties.

It is not absorbed from the surface of the skin.

When applied topically through the mucous membranes, it is practically not absorbed.

Indications for use

Tablets and ointment

Candidiasis of internal organs;
Candidiasis of mucous membranes and skin;
Candidiasis during long-term treatment with antimicrobial drugs, especially in weakened and depleted patients (prevention).

Vaginal suppositories

Vaginal candidiasis;
Fungal complications during local antimicrobial therapy (prevention).

Rectal suppositories

Candidiasis of the lower intestine;
Fungal infections in the pre- and postoperative periods (prevention).

Contraindications

Functional liver disorders;
Peptic ulcer of the stomach and duodenum;
Pancreatitis;
Pregnancy;
Hypersensitivity to the components of the drug.

Instructions for use of Nystatin: method and dosage

Pills

Nystatin tablets are taken orally, regardless of meals.

When treating candidiasis of internal organs, it is recommended to use the following dosage regimen:

Adults - 4-8 times a day, 500,000 units (for generalized candidiasis - up to 6,000,000 units per day);
Children 1-3 years old – 3-4 times a day, 250,000 units; children from 3 years old – 4 times a day, 250,000-500,000 units.

Course duration is 10-14 days. If necessary, the course of treatment can be repeated after a week.

External ointment

When treating candidiasis of the mucous membranes and skin, the ointment is applied to the affected areas in a thin layer 2 times a day. Treatment should be carried out daily for 7-10 days.

Combination therapy with Nystatin in tablet form is possible.

Vaginal suppositories

Nystatin should be administered into the vagina after hygiene procedures.

Rectal suppositories

Nystatin suppositories are injected deep into the rectum.

Single dose – 1 suppository, frequency of use – 2 times a day (morning and evening). Course duration is 10-14 days.

If necessary, repeated treatment courses are possible.

Side effects

Digestive system: vomiting, nausea, diarrhea (for tablets and rectal suppositories);
Allergic reactions: chills, itchy skin, fever;
Other: there is a possibility of spread of resistant forms of fungi, which may lead to discontinuation of therapy.

Overdose

No cases of Nystatin overdose have been recorded.

Special instructions

In cases of side effects, it is necessary to reduce the dose or discontinue therapy.

Treatment with vaginal suppositories should not be interrupted during menstruation. For fungal diseases of the vagina, simultaneous treatment of the sexual partner is recommended. During therapy, sexual intercourse should be avoided.

Use during pregnancy and lactation

It is prohibited to use Nystatin in the form of tablets and vaginal suppositories during pregnancy.

The drug in the form of rectal suppositories can be used to treat pregnant women, provided that the expected risk to the fetus is lower than the potential benefit to the mother.

Nystatin in ointment form can be used during pregnancy and breastfeeding.

There is no data on the excretion of the drug in the form of tablets into breast milk, therefore, if it is necessary to use it during lactation, it is recommended to stop breastfeeding.

It is allowed to use Nystatin in the form of vaginal suppositories and rectal suppositories during lactation (the drug is practically not absorbed through the mucous membranes).

Use in childhood

Nystatin ointment can be used to treat children.

It is prohibited to use the drug in tablet form to treat patients under the age of 3 years.

According to the instructions, Nystatin in the form of vaginal and rectal suppositories cannot be used to treat patients under the age of 18 years.

For impaired renal function

Nystatin in tablet form should be used with caution in patients with kidney disease.

For liver dysfunction

Nystatin in tablet form is contraindicated for use in cases of liver dysfunction.

Drug interactions

When Nystatin is used together with clotrimazole, the activity of the latter decreases.

Analogs

Analogues of Nystatin are: Levoy, Natamycin, Ketoconazole, Miconazole, Clotrimazole, Fluconazole, Intraconazole.

Terms and conditions of storage

Store in a dry, dark place, out of reach of children.

Best before date:

Tablets – 2 years at a temperature of 18-20 °C;
Rectal and vaginal suppositories – 2 years at temperatures up to 5 °C;
Ointment for external use – 3 years at temperatures up to 5 °C.

Conditions for dispensing from pharmacies

Tablets are available with a prescription, ointments and suppositories are available without a prescription.

The site provides reference information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. Consultation with a specialist is required!

The drug Nystatin

Nystatin belongs to the group antifungal drugs and is used to treat candidiasis, which is caused by fungi of the genus Candida and aspergillus. This drug can be used to treat candidiasis of the oral cavity, skin, vagina and intestines, since it is not absorbed into the blood and acts on the fungus locally. Nystatin has no effect on normal bacterial flora. When taken orally, it is excreted from the body practically unchanged along with feces.

Nystatin has a destructive effect on the cell membranes of fungi and, penetrating inside the cell, causes its suppression or death. It can be used for a long time, because fungi do not develop resistance to it for a long time. The drug is available in various pharmacological forms and, due to its low toxicity and effectiveness, can be used among almost all groups of patients, excluding pregnant women and people with individual intolerance to this drug.

Release forms

Nystatin is available in a variety of forms:

tablets - 250 and 500 thousand units, 10 pieces in a blister, 20 pieces per package;
granules for preparing a suspension (Fungostatin) - 100 thousand units in 1 granule, 7.5 g in a bottle;
ointment - 100 thousand units per 1 g, 15 or 30 g in tubes;
rectal suppositories – 500 thousand units, 10 pcs. in packaging;
vaginal suppositories - 250 or 500 thousand units, 10 pieces per package.

Nystatin granules and tablets can be used to treat or prevent fungal infections caused by various causes. Granules are convenient to use for preparing a suspension for children. The tablets can be used for preparing Nystatin solution and for oral administration.

Rectal and vaginal suppositories include, in addition to Nystatin, a number of additional substances that make it more convenient for the treatment of candidiasis of the vagina and lower intestines. Suppositories should be administered after toileting the perineal area, following all the doctor’s recommendations.

Nystatin ointment for external use is used to treat skin candidiasis. In addition to Nystatin, it contains components such as white petrolatum and lanolin, which ensure uniform distribution of the active substance. If necessary, this ointment can be used not only for the treatment of cutaneous candidiasis, but also for the treatment of candidiasis of the vulva and anus.

Instructions for use of Nystatin

Indications for use

Prevention of candidiasis during long-term antibiotic treatment;
prevention of intestinal candidiasis in the preoperative period and after surgery;
prevention of candidiasis of the external genitalia with external use of antibacterial drugs;
treatment of candidiasis of the vagina or gastrointestinal tract;
treatment of candidiasis of the skin or mucous membranes.

Contraindications

pregnancy;
breastfeeding period;
severe disturbances in liver function;
hypersensitivity to Nystatin.

Side effects

when taken orally and when administered rectal suppositories - nausea, vomiting (sometimes), diarrhea, discomfort and abdominal pain;
when using vaginal suppositories, allergic reactions are possible;
with long-term use - in rare cases, fungal resistance to the drug may develop and it will not be effective;
when taken orally in any form, allergic reactions are possible (fever, chills, itchy skin, rashes).

Before inserting the suppository, the woman must toilet the external genitalia and insert the Nystatin suppository into the vagina with clean hands.

As a rule, suppositories of 500 thousand units are prescribed for the treatment of thrush, but in some cases a dosage of 250 thousand units may be prescribed. It is recommended to administer suppositories twice a day: morning and evening. The course of treatment is usually about two weeks, but in some cases the duration of use of Nystatin may be increased. Suppositories should not be used during menstruation and during pregnancy and lactation.

In the treatment of thrush, gynecologists often prescribe, along with the use of suppositories, an ointment based on Nystatin, which must be applied 2 times a day after the administration of the suppository. The course of its use can last from several days to two weeks, and in case of chronic thrush, a second course of treatment can be prescribed after three weeks.

It is advisable to carry out parallel treatment of the sexual partner with nystatin ointment, which in these cases is applied to the head of the penis twice a day. This measure is explained by the fact that, despite the absence of clinical manifestations of thrush, a man may be a carrier of a fungus of the genus Candida, and sexual intercourse with him after treatment of the disease can provoke a relapse of the disease.

In some cases, Nystatin tablets are used to treat thrush, which develops against the background of long-term illness or treatment with antibacterial drugs. The dosage of the drug is carried out according to the age of the patient, and the duration of treatment is determined by the doctor.

In recent years, Nystatin has been used less frequently for the treatment of thrush, since the modern pharmacological industry produces a large number of other antifungal drugs (Levorin, Betadine, Clotrimazole, Terzhinan, etc.), which are more convenient to use. Despite this, in some special clinical cases, gynecologists prescribe Nystatin. As a rule, this drug is well tolerated by patients and rarely causes adverse reactions.

Interaction of Nystatin with other drugs

Nystatin interacts with few pharmacological drugs, since it practically “transits” through the human body. It is not absorbed or accumulated, does not penetrate through the mucous membranes into the blood, and does not undergo any biotransformation process.

The only exceptions are some drugs with which it can interact and lose its activity or reduce the effectiveness of a particular drug.

(Marvelon, Logest, etc.) - their effectiveness under the influence of Nystatin may decrease, and the risk of breakthrough (intermenstrual) bleeding increases;
when retinol drugs are combined with Nystatin, the risk of increased intracranial pressure increases.

Vaginal suppositories Nystatin belong to a group of drugs that have an antifungal effect.

The drug Nystatin is available in various forms (ointment, tablets, rectal suppositories) and is characterized by a wide range of applications.

Without going into the pharmacological details of the mechanism of action of nystatin on the fungal membrane, we note that the active substance is capable of destroying yeast-like fungi from the genus Candida.

Forms of release and use of Nystatin:

Tablets and ointment are used for candidiasis of internal organs
Vaginal suppositories - for vaginal candidiasis
Rectal suppositories are prescribed for candidiasis of the lower intestine and for the prevention of fungal diseases after or before surgery.

Vaginal suppositories Nystatin are known to women with (candidiasis). The course of treatment is two weeks.

Gynecologists insist on completing a full therapeutic course. The absence of symptoms is not a reason to stop using the medicine, since yeast-like microorganisms may not be completely destroyed, and after some time the disease will return. Suppositories are used 2 times a day, 1 suppository.

Contraindications include pregnancy and lactation. Side effects are associated with diarrhea, vomiting, nausea, chills and abdominal pain.

Vaginal suppositories are stored in the refrigerator. Due to these storage conditions, it is not possible to take them into a travel first aid kit.

After the first trimester, vaginal suppositories are used if the benefit to the expectant mother outweighs the risk to the developing fetus. Again, prescribing suppositories is the responsibility of the doctor, and not the mother, who has read reviews and advice on forums.

During pregnancy, it is advisable to use the drug Nystatin not in the form of suppositories, but in the form of an ointment. External application promotes effective action and rapid local absorption.

For the correct treatment of thrush in pregnant women. Identifying the cause of thrush is not easy. For a quick recovery, along with medications, it is recommended to change your diet by removing sweets from it. Yeast-like fungi feed on sweet foods. Many women who have reduced their consumption to a minimum have forgotten about thrush.

There are a number of drugs that are used from the first stages of pregnancy and do not harm the fetus: Hexicon, Pimafucin and Livarol.

If you are breastfeeding and you have been prescribed Nystatin, you should stop breastfeeding for the duration of treatment. The active substances of the drug pass into breast milk.

During pregnancy and lactation, approach the choice of any medications with caution, consulting a gynecologist.

The use of Nystatin vaginal suppositories is due to their rapid action. The lack of effect is explained by the wrong choice of medication or mistakes made during treatment. To defeat thrush, follow the advice of your gynecologist.

A specialist will tell you more about the drug Nystatin in the video:

Nystatin is a polyene antibiotic that is active against pathogenic fungi.

It is used for the treatment and prevention of diseases caused by microorganisms against which the drug is effective. It is produced in the form of tablets for oral use, as well as in the form of suppositories for vaginal and rectal administration.

Usually well tolerated by the body, except in cases of intolerance to the drug.

Clinical and pharmacological group

Antifungal antibiotic.

Conditions for dispensing from pharmacies

Dispensed without a doctor's prescription.

Prices

How much do Nystatin suppositories cost in pharmacies? The average price is 55 rubles.

Release form and composition

Vaginal suppositories, tablets, ointment.

1 suppository of nystatin contains 250,000 units or 500,000 units.
In 1 g of ointment - 100,000 units.
1 tablet contains 500,000 units.

Pharmacological effect

Nystatin is an antifungal antibiotic. It is started to be taken at the first symptoms of thrush. The medicine is effective against fungi of the genus Candida spp and aspergillus. The active substance binds to sterols in the cell membrane of fungi, causing disruption of its permeability and destruction of the main components of the cell.

When applied topically, the antibiotic is practically not absorbed. After oral administration, the drug is poorly dissolved in the gastrointestinal tract.

Indications for use

Nystatin is available in the form of suppositories. In this case, the drug is used rectally and vaginally.

Indications:

Intestinal candidiasis.

Nystatin is prescribed for the prevention and treatment of diseases caused by yeast-like fungi of the genus Candida

Contraindications

The drug has contraindications:

Pancreatitis;
Pregnancy;
Functional liver disorders;
Peptic ulcer of the stomach and duodenum;
Hypersensitivity to the components of the drug.

Use during pregnancy and lactation

In recent years, Nystatin is rarely prescribed to women during pregnancy. This drug, according to the instructions, is contraindicated for use in pregnant women and, due to the presence of a wide range of other antifungal agents, can be successfully replaced with safer antifungal drugs (for example, Pimafucin, Polygynax, Difluzol, etc.).

In rare cases, Nystatin in tablets or vaginal suppositories is prescribed to pregnant women, but in these forced cases its dosage is reduced.

The only safe method of treatment with Nystatin during pregnancy can only be considered the use of an ointment based on this drug. When used externally to treat candidiasis of the mucous membranes or skin, it is not absorbed into the blood and cannot harm the unborn child.

Dosage and method of administration

The instructions for use indicate that Nystatin should be administered into the vagina after hygiene procedures.

Rectal suppositories

Nystatin suppositories are injected deep into the rectum.

Single dose – 1 suppository, frequency of use – 2 times a day (morning and evening). Course duration is 10-14 days.

If necessary, repeated treatment courses are possible.

Side effects

Very rare: local reactions (itching, burning).

Other: there may be a risk of the spread of resistant forms of fungi. If thrush symptoms persist, consult your doctor.

Overdose

Since Nystatin suppositories act locally and the absorption of the drug into the systemic circulation is minimal, the likelihood of an overdose even with long-term use of suppositories is practically absent.

If the suppository is accidentally ingested, the patient must induce vomiting and be given activated charcoal or one of the enterosorbents.

Special instructions

If adverse reactions develop, the dose should be reduced or the drug discontinued.

During menstruation, treatment with vaginal suppositories should not be interrupted. For fungal diseases of the vagina, simultaneous treatment of the sexual partner is recommended. During treatment, sexual intercourse should be avoided.

Drug interactions

With simultaneous use of nystatin and clotrimazole, the activity of the latter decreases.

Nystatin is a medicinal antifungal drug that has a fungistatic effect. Available in the form of tablets (250,000 and 500,000 units), vaginal and rectal suppositories, and ointments.

Pharmacological action of Nystatin

According to the instructions, the active ingredient of the drug is nystatin.

Excipients of the tablets are emulsion KE-10, titanium dioxide pigment, vanillin, Tween 80, methylcellulose, stearin, medical talc, stearic acid, milk sugar, potato starch.

An auxiliary component of Nystatin suppositories is a fat base. The ointment contains excipients such as medical petroleum jelly and anhydrous lanolin.

According to the instructions, Nystatin is a polyene group antibiotic produced by the actinomycete Streptomyces noursei.

When used, Nystatin affects the yeast-like fungi Candida and Aspergillus. The medicine blunts the development of vegetative forms of dysenteric amoebae in the intestines.

Nystatin has been noted to be highly effective for thrush.

In accordance with the instructions, Nystatin in all forms of release is not active against viruses, actinomycetes and bacteria.

Indications for use of Nystatin

Methods of using Nystatin and dosage

The duration of the course of use of Nystatin is 10-14 days.

A combination of local treatment with oral Nystatin is effective.

Side effects of Nystatin

Nystatin in all forms of release can cause the development of adverse reactions in the form of allergies, accompanied by rashes, itching, skin hyperemia, and urticaria.

When using Nystatin suppositories, vaginal irritation is possible; when taking Nystatin tablets, a bitter taste in the mouth, nausea, abdominal pain, vomiting, and diarrhea may occur.

Contraindications to the use of Nystatin

The medicine is not prescribed to patients with hypersensitivity to its components, liver dysfunction, peptic ulcers of the stomach and duodenum, pancreatitis.

According to the instructions for Nystatin, the drug can be used during pregnancy and lactation.

Overdose

According to reviews, overdose may increase side effects.

Additional information

During Nystatin therapy for thrush, you should abstain from sexual intercourse. Joint treatment of both sexual partners is also recommended.

In accordance with the instructions, Nystatin should be stored in a cool, dark place out of reach of children.

Nystatin is available from pharmacies by prescription.

Shelf life – 24 months.

The drug is available in the following forms:

In the form of vaginal and rectal suppositories, which can comprehensively affect the infection. The candles are packed in special cells in the amount of five pieces. One package contains detailed instructions on how to take the medicine. Such candles are produced in the shape of a torpedo, with a yellowish tint.
In tablet form. The dragees are covered with a light yellow shell. The tablets have a slight vanilla scent. Such tablets are available for sale in quantities of twenty pieces in dark glass bottles. Tablets are also available for sale in special contour cells in a cardboard packaging box.
In the form of an ointment. The ointment is intended for external use. The color of the composition of the drug is brownish-yellow. Available in specially designed tubes.

One tablet contains nystatin, as well as auxiliary, additional components in the form of milk sugar, magnesium carbonate, potato starch, vanillin and other components.
One suppository for rectal administration contains nystatin and auxiliary components in the form of propyl ether and parahydroxybenzoic acid. Also included in the additional components is citric acid, as well as petroleum jelly.
One suppository for vaginal administration contains nystatin and auxiliary components in the form of propyl ester of parahydroxybenzoic acid, as well as citric acid.
Composed of one gr. The external ointment contains nystatin and an auxiliary component in the form of anhydrous lanolin and medical petroleum jelly.

A drug such as Nystatin is used in two ways: intravaginally and rectally. The method of administration depends, first of all, on the indications and prescription of the doctor.

To take this drug, the patient must lie in a comfortable position and insert the suppository deep into the rectal cavity or vagina.

The drug must be administered one piece at a time twice a day. After the drug has been administered, the patient must remain in the same position so that the medicine dissolves and does not leak out.

The course of therapy can continue for as long as it is prescribed directly with the doctor.

According to the instructions, treatment lasts on average about two weeks. If there is no therapeutic effect or the condition worsens, the patient should consult a doctor. It is also worth keeping in mind that during therapy with this drug, discharge may be increased. As prescribed by the doctor, the course of therapy can be prescribed again.

Quite often, when prescribing treatment, doctors prescribe several drugs that can overcome the disease.

It is worth making a reservation, drugs that help eradicate the problem of candidiasis contain active substances. It is precisely due to such circumstances that not all groups of drugs are compatible. Especially when it comes to drugs for the treatment of sexually transmitted infections.

In gynecological practice, a drug such as Nystatin is not recommended for use in parallel with the drug Clotrimazole. It is worth noting an important factor - the presence of a sufficiently highly active substance that can displace the active substances of other drugs. When two drugs interact, the effectiveness of Clotrimazole is significantly reduced.

The price of Nystatin in various forms of release depends on various factors: the city, the manufacturer of this medicine. That is why, before purchasing this drug, it is worth checking how different prices are in pharmacies.

On average in Russia the cost of various dosage forms of Nystatin is as follows:

vaginal suppositories 500 thousand units, 10 pieces per package – 42-60 rubles;

Before use, you should consult a specialist.

The downside of most drugs, including those described in this article, is side effects. Often medications greatly harm the body, subsequently causing complications in the functioning of the kidneys and liver.

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We wish you good health!

Nystatin

belongs to the group

antifungal drugs

and is used for treatment

candidiasis

The price of Nystatin in various forms of release depends on various factors: the city or region and the pharmacy selling the drug, the manufacturer of this drug. That is why before purchasing this drug it is worth checking the price in different pharmacies. The average price of various dosage forms of Nystatin is as follows:

tablets of 250 thousand units, 20 pieces per package - 14-16 rubles;
tablets 500 thousand units, 20 pieces per package - 13-30 rubles;
Fungostatin granules, 100 thousand units, 7.5 g per package – 400 rubles;
vaginal suppositories 250 thousand units, 10 pieces per package – 33-40 rubles;
vaginal suppositories 500 thousand units, 10 pieces per package – 42-60 rubles;
rectal suppositories 500 thousand units, 10 pieces per package – 47-80 rubles;
ointment 100 thousand units per 1 g, tube 15 g – 21-48 rubles;
ointment 100 thousand units per 1 g, tube 30 g - 30-45 rubles.

The dosage form contains a certain amount of excipients: petroleum jelly, butyloxyanisole, citric acid, butyloxytoluene, semi-synthetic glycerides, which is due to the specifics and localization of the use of the antifungal agent.

Suppositories with Nystatin significantly reduce the activity of Clotrimazole, so it is not recommended to use them at the same time. At the same time, douching significantly neutralizes the therapeutic effect of suppositories.

Suppositories also give excellent results when used prophylactically to prevent negative consequences that occur from long-term drug therapy with antibacterial drugs and antibiotics of other groups.

For vaginal candidiasis, suppositories are usually used. This disease is scientifically called “vaginal candidiasis”, but popularly it is called “thrush”.

Today, candidiasis is the most common problem for most women. This disease is expressed by swelling of the vaginal mucosa, the appearance of cheesy discharge from the genital tract, burning and itching.

This causes a lot of trouble and discomfort, and therefore requires immediate treatment with antifungal agents. The main causative agent of this disease is yeast-like fungi, which in medicine are called Candida fungi.

“Nystatin” is the most common medicine, affordable and of very high quality. Judging by the reviews, the price of Nystatin suppositories is affordable.

They contain nystatin in a dosage of 250,000 or 500,000 units, petroleum jelly, citric acid, butyloxytoluene, semi-synthetic glycerides (serve as the basis for suppositories).

For candidiasis of the genital tract in women, a remedy is prescribed in the form of vaginal suppositories. Often, women with similar problems treat thrush on their own, not considering it a serious disease, and therefore do not seek medical help.

In these cases, relapses are possible, since only a qualified doctor is able to prescribe the correct dosage and determine the duration of use of the medicine. If the drug is used incorrectly, not all pathogens may be destroyed, and this will provoke further development of the disease, its transition to a chronic form.

There are many reviews about Nystatin suppositories, but we will talk about them at the end of the article.

Experts consider this drug to be proven and effective. It is often prescribed to patients. But some adverse reactions of the body cannot be ruled out, which go away on their own after stopping the medication.

Since the drug has been used to treat candidiasis for more than half a century, a lot of information about it has accumulated. Patients are overwhelmingly satisfied with this medicine, since it is inexpensive, treats effectively and is very convenient to use.

For women, Nystatin suppositories for thrush, judging by reviews, help quickly eliminate painful symptoms. Rectal suppositories also do not cause a negative reaction from patients.

As for tablets, they are sometimes mentioned in a negative way, since they cause adverse reactions from the gastrointestinal tract (usually diarrhea). However, for effective treatment with ointment or suppositories, the tablet version should be taken simultaneously for a systemic effect on the infection. That is, in general, the drug is reliable, effective, time-tested and safe.

However, sometimes, in search of analogues, buyers are interested in which is better: nystatin or fluconazole? There is no definite answer, since the latter has an undeniable advantage in the form of a single dose, in contrast to a weekly course of Nystatin. However, Fluconazole also has various contraindications, so the choice of a particular medicine should be made by the attending physician.

The drug is based on an antibiotic of the polyene group. Its peculiarity is that it inhibits the cells of the Candida fungus, which is the cause of the development of symptoms of thrush in women. At the same time, the product does not affect beneficial bacteria. Thus, Nystatin has a selective effect.

Tablets for thrush are used more often in chronic and recurrent forms of the disease, when local therapy is not enough.

Vaginal suppositories with Nystatin are used for vaginal candidiasis. Their introduction is recommended after hygiene procedures.

The ointment is intended for treatment of candidiasis of the skin, but it can also be used for thrush in the vagina, as well as in the anus.

When taking the drug, the following recommendations should be followed:

Combining the medicine with alcoholic beverages is unacceptable;
when undergoing therapy, it is necessary to postpone intimate relationships until recovery;
suppositories are not used during menstruation;
treatment of the sexual partner is necessary.

The cost of the drug depends on the form of release and manufacturer, as well as on the pharmacy’s policy. Average prices for Nystatin:

tablets, pack of 20 pcs. – from 15 rubles;
vaginal suppositories, pack of 10 pcs. – from 35 rubles;
ointment, tube – from 20 rubles.

Nystatin is an effective remedy for candidiasis in women. However, its use should be as prescribed by a doctor in order to avoid unpleasant consequences.

Using Nystatin, you can cure diseases that were caused by yeast-like fungi on the mucous membranes of the mouth, vagina, gastrointestinal tract, lungs, kidneys, etc. It should also be noted that Nystatin is also prescribed for prophylactic purposes during long-term use of antibiotics and drugs of the group penicellins, as well as people with exhausted and weakened immune systems.

The main advantage of the drug is its release form. Nystatin is available in the form of ointments, tablets and suppositories, which makes it possible to treat candidiasis of various forms of its localization.

Analogs of this remedy are drugs such as Mycostatin, Anticandin, Fungicidin, Levorin and d/r

After analyzing patient reviews about the treatment of thrush with Nystatin suppositories, we can conclude that allergies are very rarely detected when using suppositories. Also, in some cases, a decrease in the effectiveness of treatment with this drug was noticed, in comparison with new ones, which is due to the fact that the fungi become resistant to the active substance.

But at the same time, sometimes it was Nystatin suppositories that were detected more effectively.

Contraindications

Like any drug, Nystatin also has a number of contraindications. It is not allowed to take Nystatin in any form during pregnancy, during breastfeeding, in the presence of an ulcer, if the patient has pancreatitis and severe liver dysfunction, as well as in case of personal intolerance to the drug.