The description is valid on 23.04.2015

• Latin name: Lipoic acid
• ATX code: A16AX01
• Active substance: Thioctic acid
• Manufacturer: URALBIOPHARM, MARBIOPHARM (Russia)

Compound

The tablet contains 12 or 25 mg of active substance. 1 ampoule contains 10 ml of solution.

Release form

Lipoic acid is produced in the form of tablets in a special film coating in packages of 10, 50, 100 pieces.

pharmachologic effect

The active component is endogenous, which is capable of binding aggressive free radicals . Alpha lipoic acid acts as a coenzyme in the transformation of substances that have pronounced antioxidant effects.

Such substances are capable of exhibiting protective functions in relation to cells, protecting them from the aggressive effects of reactive radicals that are formed during intermediate metabolism, or at the time of the breakdown of foreign exogenous substances (including heavy metals).

The active substance is involved in mitochondrial substances inside the cell. By stimulating the utilization of glucose, thioctic acid is able to exhibit synergism with. In patients with a change in the level of pyruvic acid concentration in the blood is recorded.

According to the mechanism and nature of the biochemical effect, the active substance is similar to. The active substance has a lipotropic effect, which manifests itself in accelerating the utilization processes of lipids in the hepatic system. Lipoic acid can stimulate the transfer of fatty acids from the liver system to various tissues in the body.

The nature of the drug is a detoxification effect when salts of heavy metals enter the body and in case of other poisoning. Thioctic acid changes cholesterol metabolism, improves the general and functional condition of the liver.

Pharmacodynamics and pharmacokinetics

Pharmacokinetics indicators and descriptions of pharmacodynamics are not found in the medical literature.

Indications, use of Lipoic acid

The medication is widely used in the treatment of liver pathology, nervous system, intoxication, diabetes, and to alleviate the course of cancer.

Main indications:

• against the background of alcoholism;
• chronic;
• acute liver failure;
• intoxication with heavy metals, sleeping pills, carbon, carbon tetrachloride, mushrooms;
• viral hepatitis with increasing jaundice ;
• diabetic polyneuritis ;
• alcoholic polyneuropathy;
• poisoning with toadstool;
• fatty liver degeneration;
• dyslipidemia;
• coronary

During the course of treatment, the medication acts as a corrector and synergist to prevent the development of “withdrawal syndrome” and gradually reduce the dose of glucocorticosteroid.

Lipoic acid for weight loss

The mechanism of action of the active substance allows the medication to be used to lose excess weight. The effect is more pronounced when simultaneously actively playing sports. Lipoic acid can trigger the fat burning mechanism, but it is not possible to burn absolutely all excess fat on its own, so intense physical activity is required.

Muscle tissue “attracts” nutrients during training, and thioctic acid can increase endurance, enhance fat burning and increase the overall effectiveness of physical activity. Simultaneous adherence to the diet allows you to achieve the greatest results.

Lipoic acid dosage for weight loss

Usually 50 mg of medication is sufficient. The minimum threshold is 25 mg. The most effective time to take the drug to achieve maximum results in the fight against excess weight:

• before or immediately after breakfast;
• at the last daily meal;
• after training, physical activity.

Reviews

The drug works well when following a diet and at the same time an active combination of exercises in the gym. On thematic forums, users discover a little secret: the drug works better when taking carbohydrate foods (semolina or buckwheat porridge, dates, honey, pasta, rice, peas, beans, bread products).

Lipoic acid in bodybuilding

Quite often in bodybuilding, thioctic acid is combined with Levocarnitine ( , ). This is a relative of B vitamins and is capable of activating fat metabolism. Levocarnitine releases fat from cells, stimulating energy expenditure.

Contraindications

Age limit – up to 16 years.

Side effects

• epigastric pain;
• nausea;
• anaphylactic reactions;
• skin rashes;
• vomit;
• convulsions;
• promotion ;
• disorders of glucose metabolism ( hypoglycemia );
• headache type;
• tendency to (with functional disorders);
• pinpoint hemorrhages;
• diplopia ;
• difficulty breathing.

Lipoic acid, instructions for use (Method and dosage)

300-600 mg of thioctic acid is administered intravenously daily, which corresponds to 1-2 ampoules of 10 ml and 1 ampoule of 20 ml of concentration 3%. The duration of therapy is 2-4 weeks, after which treatment is continued in tablet form at a daily dose of 300-600 mg.

Instructions for use of Lipoic acid tablets

Orally 30 minutes before meals. Tablets should not be broken or chewed. Daily dose: 1 tablet 1 time per day (300-600 mg). The therapeutic effect is achieved by taking 600 mg per day. In the future, the dose can be halved.

At diseases of the liver system tablets are prescribed: up to 4 times a day, 50 mg for a month. A repeat course can be carried out after 1 month.

Therapy diabetic neuropathy And alcoholic polyneuropathy: start with intravenous injections with a transition to a tablet form of 600 mg per day.

Overdose

The clinical picture consists of the following negative manifestations:

• diarrhea syndrome;
• headache;
• nausea;
• epigastric pain;
• hypoglycemia.

Treatment is syndromic.

Interaction

The medication can enhance the effects of glucocorticosteroid drugs. Suppression of activity is noted Cisplatin . The drug enhances the effect of hypoglycemic agents (oral forms) and insulin.

If there is an urgent need to use drugs, it is recommended to maintain a certain time interval (at least 2 hours). Ethanol metabolites and ethanol itself weaken the effect of thioctic acid.

Terms of sale

Prescription holiday.

Storage conditions

Transportation and storage of tablets and solution is allowed only if the temperature is maintained - up to 25 degrees.

Best before date

special instructions

The main metabolic pathways are oxidation and conjugation (source - Wikipedia).

Benefits and harms

Lipoic acid is a natural antioxidant and vitamin. It helps to normalize and accelerate metabolic processes, stimulates the pancreas, removes toxins from the body, lowers blood sugar levels, improves visual perception, has a beneficial effect on heart function, reduces blood pressure, and helps normalize blood pressure.

With the use of Lipoic acid, there is a decrease in the severity of negative reactions that occur after treatment in cancer patients.

The drug has a beneficial effect on the condition of nerve endings damaged as a result of diabetes. Rarely do negative reactions occur during the use of the medication.

Similar drugs

Level 4 ATX code matches:

Preparations containing thioctic acid:

• Alpha Lipon;

For children

Thioctic acid can be used in pediatric practice from the age of 16.

During pregnancy and lactation

Lipoic acid is not used.

It is also a contraindication.

Lipoic acid reviews

Reviews of Lipoic acid for weight loss

There are a variety of reviews. Some felt absolutely no effect, maintaining their weight despite regularly taking the medication. Some users note that taking Lipoic acid in combination with intense cardio exercise and following a certain diet can significantly reduce weight without harming their health.

Patients suffering from diabetes mellitus note that the medication can reduce the severity of negative reactions of hypoglycemic drugs (in some cases it was possible to reduce the dosage) and improve overall well-being.

Lipoic acid price, where to buy

Most often, the drug is purchased for weight loss. You can buy Lipoic acid in a pharmacy in Russia for 50 rubles.

The price of Lipoic acid in Ukraine is 20 UAH, in Minsk 200 thousand Belarusian rubles.

• Online pharmacies in Russia Russia
• Online pharmacies in Ukraine Ukraine
• Online pharmacies in Kazakhstan Kazakhstan

ZdravCity

Now Foods Alpha Lipoic Acid Caps. 598.45 mg No. 60 (bud) NOW International

Alpha lipoic acid 100 mg. Evalar ANTI-AGE caps. 30 pcs. 1.1 g each Evalar CJSC

There are many drugs that contain substances necessary to maintain the health of the body and are used by pharmacology as medicines for various diseases. For example, lipoic acid, the harm and benefits of which will be discussed below.

pharmachologic effect

The vital activity of the human body is an amazing interweaving of various processes that begin from the moment of conception and do not stop for a split second throughout life. Sometimes they seem quite illogical. For example, biologically significant elements - proteins - require non-protein compounds, so-called cofactors, to function correctly. It is precisely these elements that include lipoic or, as it is also called, thioctic acid. It is an important component of many enzymatic complexes that work in the human body. Thus, when glucose is broken down, the final product will be salts of pyruvic acid - pyruvates. It is lipoic acid that is involved in this metabolic process. In its effect on the human body, it is similar to B vitamins - it also participates in lipid and carbohydrate metabolism, increases the glycogen content in liver tissue and helps reduce the amount of glucose in the blood.

Due to its ability to improve cholesterol metabolism and liver function, lipoic acid reduces the pathogenic effects of toxins of both endogenous and exogenous origin. By the way, this substance is an active antioxidant, which is based on its ability to bind free radicals.

According to various studies, thioctic acid has hepatoprotective, hypolipidemic, hypocholesterolemic and hypoglycemic effects.

Derivatives of this vitamin-like substance are used in medical practice to impart certain degrees of biological activity to drugs containing such components. And the inclusion of lipoic acid in injection solutions reduces the potential development of side effects of drugs.

What are the dosage forms?

For the drug "Lipoic acid", the dosage of the drug takes into account the therapeutic need, as well as the method of delivering it to the body. Therefore, the drug can be purchased in pharmacies in two dosage forms - in the form of tablets and in the form of a solution in ampoules for injection. Depending on which pharmaceutical company it is produced or capsules can be purchased containing from 12.5 to 600 mg of active substance in 1 unit. The tablets are produced in a special coating, which is most often yellow. The drug in this form is packaged in blisters and cardboard packs containing 10, 50 or 100 tablets. But the drug is available in ampoules only in the form of a 3% solution. Thioctic acid is also a common component of many medicinal multicomponent products and dietary supplements.

In what cases is the use of the drug indicated?

One of the vitamin-like substances important for the human body is lipoic acid. Indications for use take into account its functional load as an intracellular component important for many processes. Therefore, lipoic acid, the harms and benefits of which are sometimes the cause of controversy in health forums, has certain indications for use in the treatment of diseases or conditions such as:

• coronary atherosclerosis;
• viral hepatitis (with jaundice);
• chronic hepatitis in the active phase;
• dyslipidemia - including a change in the ratio of blood lipids and lipoproteins;
• liver dystrophy (fatty);
• intoxication with medications, heavy metals, carbon, carbon tetrachloride, mushrooms (including toadstool);
• acute liver failure;
• chronic pancreatitis due to alcoholism;
• diabetic polyneuritis;
• alcoholic polyneuropathy;
• chronic cholecystopancreatitis;
• liver cirrhosis.

The main area of ​​work of the drug "Lipoic acid" is therapy for alcoholism, poisoning and intoxication, in the treatment of liver pathologies, the nervous system, and diabetes. Also, this medicine is often used in complex therapy of oncological diseases to alleviate the course of the disease.

Are there any contraindications for use?

When prescribing treatment, patients often ask doctors - what is lipoic acid for? The answer to this question can be quite lengthy, because thioctic acid is an active participant in cellular processes aimed at the metabolism of various substances - lipids, cholesterol, glycogen. It is involved in protective processes against free radicals and tissue cell oxidation. For the drug "Lipoic acid", the instructions for use indicate not only the problems that it helps to solve, but also contraindications for use. And they are as follows:

• hypersensitivity;
• history of allergic responses to medications;
• pregnancy;
• period of feeding the baby with breast milk.

This drug is not prescribed for the treatment of children under 16 years of age due to the lack of clinical trials in this regard.

Are there any side effects?

One of the biologically important substances at the cellular level is lipoic acid. Why is it needed in cells? To carry out a range of chemical and electrical reactions in the metabolic process, as well as to reduce the effects of oxidation. But despite the benefits of this substance, it is impossible to take drugs with thioctic acid thoughtlessly, not as prescribed by a specialist. In addition, these medications can cause the following side effects:

• allergic reactions;
• epigastric pain;
• hypoglycemia;
• diarrhea;
• diplopia (double vision);
• difficulty breathing;
• skin reactions (rashes and itching, urticaria);
• bleeding (due to functional disorders of thrombocytosis);
• migraine;
• petechiae (point hemorrhages);
• increased intracranial pressure;
• vomit;
• convulsions;
• nausea.

How to take medications with thioctic acid?

For the drug "Lipoic acid", the instructions for use describe the basics of treatment depending on the initial dosage of the drug unit. The tablets are not chewed or crushed, taking them orally half an hour before meals. The drug is prescribed up to 3-4 times per day, the exact number of doses and the specific dosage of the drug is determined by the attending physician in accordance with the need for the therapy. The maximum permissible daily dosage of the drug is 600 mg of the active ingredient.

For the treatment of liver diseases, lipoic acid preparations should be taken 4 times a day in the amount of 50 mg of the active substance per dose. The course of such therapy should be 1 month. It can be repeated after a time specified by the attending physician.

Intravenous administration of the drug is prescribed in the first weeks of treatment of diseases in acute and severe forms. After this time, the patient can be transferred to the tablet form of lipoic acid therapy. The dosage should be the same for all dosage forms - intravenous injections contain from 300 to 600 mg of the active substance per day.

How to buy the drug and how to store it?

As indicated in the instructions for use of the medicine, lipoic acid is sold in pharmacies by prescription. Its use without consultation with the attending physician is not recommended, since the drug has high biological activity; its use in complex therapy should take into account compatibility with other drugs that the patient is taking.

The purchased medicine in tablet form and in injection form is stored at room temperature without access to sunlight.

Drug overdose

In therapy with any medications, including lipoic acid, it is necessary to strictly adhere to the dosage recommended by the specialist. An overdose of thioctic acid manifests itself as follows:

• allergic reactions;
• anaphylactic shock;
• pain in the epigastric region;
• hypoglycemia;
• headache;
• diarrhea;
• nausea.

Since there is no specific antidote to this substance, overdose or poisoning with lipoic acid requires symptomatic therapy while discontinuing this medication.

Is it better or worse together?

A fairly common incentive for self-medication is price and reviews for various medications, including the drug Lipoic Acid. Thinking that only benefits can be obtained from a natural vitamin-like substance, many patients forget that there is also the so-called pharmacological compatibility that must be taken into account. For example, the combined use of glucocorticosteroids and drugs with thioctic acid is fraught with increased activity of adrenal hormones, which will certainly cause a lot of negative side effects.

Since lipoic acid actively binds many substances in the body, its use should not be combined with taking medications containing components such as magnesium, calcium, potassium, and iron. Treatment with these drugs should be divided over time - a break of at least 2-4 hours will be the best option for taking the medications.

Treatment with alcohol-containing tinctures is also best done separately from taking lipoic acid, since ethanol weakens its activity.

Is it possible to lose weight by taking thioctic acid?

Many people believe that one of the effective and safe means necessary for correcting weight and shape is lipoic acid for weight loss. How to take this drug to remove excess fat deposits? This is not a difficult question, considering that without certain physical activity and adjustments to the diet, no weight loss can be achieved with any medications. If you reconsider your attitude to physical education and proper nutrition, then the help of lipoic acid in losing weight will be very noticeable. You can take the drug in different ways:

• half an hour before breakfast or half an hour after it;
• half an hour before dinner;
• after an active sports workout.

This attitude to weight loss involves the use of lipoic acid preparations in an amount of 25-50 mg per day. It will help metabolize fats and sugars, as well as remove unnecessary cholesterol from the body.

Beauty and thioctic acid

Many women use the drug "Lipoic acid" for the face, which helps make the skin cleaner and fresher. Using preparations with thioctic acid, you can improve the quality of a regular moisturizer or nourishing cream. For example, a couple of drops of an injection solution added to a cream or lotion that a woman uses every day will make it more effective in the fight against active radicals, pollution, and deterioration of the skin.

For diabetes

One of the significant substances in the metabolism and metabolism of glucose, and therefore insulin, is lipoic acid. For diabetes and types 1 and 2, this substance helps to avoid serious complications associated with active oxidation, and therefore the destruction of tissue cells. As studies have shown, oxidative processes are activated with a significant increase in blood sugar, and it does not matter for what reason such a pathological change occurs. Lipoic acid acts as an active antioxidant, which can significantly minimize the effects of the destructive effects of blood sugar on tissue. Research in this area continues, and therefore drugs with thioctic acid for diabetes mellitus should be taken only on the recommendation of the attending physician with regular monitoring of blood counts and the patient’s condition.

What do they say about the drug?

A component of many medications that has significant biological activity is lipoic acid. The harm and benefits of this substance are a source of constant debate between specialists and patients. Many consider such drugs to be the future of medicine, whose help in the treatment of various diseases will be proven in practice. But many people think that these drugs only have a so-called placebo effect and do not carry any functional load. But still, for the most part, reviews about the drug "Lipoic acid" have a positive and recommendatory connotation. Patients who took this medicine as a course report that after therapy they felt much better and had a desire to lead a more active lifestyle. Many people note an improvement in their appearance - their complexion has become clearer, acne has disappeared. Patients also note a significant improvement in blood counts - a decrease in sugar and cholesterol after taking a course of the drug. Many people say that lipoic acid is often used for weight loss. How to take such a remedy to lose extra pounds is a pressing question for many people. But everyone who took the drug for the purpose of losing weight says that without changing their diet and lifestyle, there will be no result.

Similar drugs

Biologically significant substances present in the human body itself help in the fight against many diseases, as well as pathological conditions that affect health. For example, lipoic acid. Although the harm and benefits of the drug are controversial, this substance still plays a huge role in the treatment of many diseases. A drug with an identical name has many analogues, which include lipoic acid. For example, "Octolipen", "Espa-Lipon", "Tiolepta", "Berlition 300". It can also be found as part of multi-component products - “Alphabet - Diabetes”, “Complivit Radiance”.

Every patient who wishes to improve their condition with the help of medications or biologically active food supplements, including lipoic acid preparations, should first obtain advice from a specialist regarding the rationality of such treatment, as well as any contraindications.

In this article you can read the instructions for use of the drug Lipoic acid. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Lipoic acid in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Lipoic acid analogues in the presence of existing structural analogues. Use for the treatment of diabetic polyneuropathy and weight loss in adults, children, as well as during pregnancy and lactation. Composition of the drug.

Lipoic acid- is an endogenous antioxidant that binds free radicals. Thioctic (alpha-lipoic) acid (the active ingredient of the drug Lipoic acid) is involved in the mitochondrial metabolism of the cell; it functions as a coenzyme in the complex of transformation of substances that have a pronounced antitoxic effect. They protect the cell from reactive radicals arising during intermediate metabolism or during the breakdown of exogenous foreign substances, and from heavy metals. Thioctic acid exhibits synergism with insulin, which is associated with increased glucose utilization. In patients with diabetes mellitus, thioctic acid leads to a change in the concentration of pyruvic acid in the blood.

Compound

Thioctic acid + excipients.

Indications

• diabetic polyneuropathy;
• alcoholic polyneuropathy;
• fatty liver;
• cirrhosis of the liver;
• chronic hepatitis;
• hepatitis A;
• intoxication (including salts of heavy metals);
• poisoning with toadstool;
• hyperlipidemia (including with the development of coronary atherosclerosis - treatment and prevention).

Release forms

Film-coated tablets 12 mg, 25 mg, 200 mg, 300 mg and 600 mg.

Injections in ampoules for injection (3% solution).

Instructions for use and dosage

Lipoic acid is administered intravenously at 300-600 mg per day, which is 1-2 ampoules of 10 ml + 1 ampoule of 20 ml of 3% solution. The duration of treatment is 2-4 weeks. After this, maintenance therapy is continued in the form of taking pills. The daily dose of maintenance therapy is 300-600 mg per day.

To treat liver diseases and intoxications, tablets of 25 mg or 12 mg are used. They are swallowed. For adults, the dose is 50 mg up to 4 times a day. Children over 6 years old can drink them up to 3 times a day. And so on until a month. If necessary, the course of treatment is repeated after 1 month.

For the treatment of alcoholic and diabetic neuropathy, tablets of 200, 300 and 600 mg are used. They are swallowed whole on an empty stomach with water. half an hour before breakfast, up to 600 mg per day. Treatment begins with parenteral administration.

Side effect

• diplopia;
• convulsions;
• pinpoint hemorrhages in the mucous membranes and skin;
• platelet dysfunction;
• with rapid administration - increased intracranial pressure;
• dyspeptic symptoms (including nausea, vomiting, heartburn);
• allergic reactions (urticaria, anaphylactic shock);
• hypoglycemia.

Contraindications

• pregnancy;
• lactation period (breastfeeding);
• children under 6 years of age (up to 18 years in the treatment of diabetic and alcoholic polyneuropathy);
• hypersensitivity to thioctic acid.

Use during pregnancy and breastfeeding

Lipoic acid is contraindicated during pregnancy and lactation.

Use in children

Contraindicated in children under 6 years of age (under 18 years of age in the treatment of diabetic and alcoholic polyneuropathy).

special instructions

During the treatment period, regular monitoring of blood glucose concentrations (especially at the beginning of therapy) in patients with diabetes mellitus is necessary.

There is an opinion about the possibility of using the drug Lipoic acid for weight loss, but there is no clinical data on the use of the drug for weight loss.

Drug interactions

With simultaneous use, it is possible to enhance the hypoglycemic effect of insulin and oral hypoglycemic agents.

When used simultaneously with cisplatin, its effectiveness may be reduced.

Thioctic acid (in solution for infusion) is incompatible with dextrose solution and Ringer's solution.

Analogues of the drug Lipoic acid

Structural analogues of the active substance:

• Alpha lipoic acid;
• Berlition;
• Lipamide tablets;
• Lipothioxone;
• Neurolipon;
• Octolipen;
• Thiogamma;
• Thioctacid;
• Thioctic acid;
• Thiolepta;
• Thiolipon;
• Espa Lipon.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.

Content

To regulate metabolism in the skin and increase muscle endurance in athletes, Lipoic acid is used - the instructions for using the capsules include information about various indications for their use. The natural active substance has antioxidant properties and promotes weight loss. Read the instructions for the drug in more detail.

Alpha lipoic acid - instructions for use

According to the pharmacological classification, Alpha lipoic acid 600 mg is included in the group of antioxidants with a general strengthening effect. The drug is able to regulate lipid and carbohydrate metabolism due to the active substance thioctic acid (thioctic or lipoic acid). Fatty acid binds free radicals, thereby protecting body cells from toxins.

Composition and release form

Lipoic acid is available in tablets and solution form for infusion. Detailed composition of each medicine:

	Pills
Active substance concentration, mg	12-600 per 1 piece.
Additional composition	Starch, calcium stearate, yellow water-soluble dye, glucose, liquid paraffin, talc, polyvinylpyrrolidone, stearic acid, magnesium carbonate, aerosil, wax, titanium dioxide	Ethylenediamine, water, disodium ethylenediaminetetraacetic acid, sodium chloride
Description	Film-coated capsules	Transparent yellowish liquid
Package	10, 20, 30, 40 or 50 pcs. in a pack	Ampoules 2 ml, 10 pcs. in the box

pharmachologic effect

The drug is an endogenous antioxidant that binds free radicals and participates in the mitochondrial metabolism of liver cells. Lipoic acid functions as a coenzyme in the complex of transformation of substances that have an antitoxic effect. These components protect cellular structures from reactive radicals that are formed during the breakdown of exogenous foreign substances, as well as from heavy metals.

Thioctic acid is an insulin synergist, which is associated with a mechanism for increasing glucose utilization. Patients with diabetes mellitus taking the drug experience a change in the concentration of pyruvic acid in the blood. The active substance has a lipotropic effect, affects cholesterol metabolism, protects the liver, and is close to B vitamins in the nature of its biochemical effect.

When ingested, the drug is quickly absorbed and distributed in tissues, has a half-life of 25 minutes, and reaches maximum concentration in plasma in 15-20 minutes. The substance is excreted by the kidneys in the form of metabolites, which are formed in the body by 85%; a small part of the unchanged substance is excreted in the urine. Biotransformation of the component occurs due to oxidative reduction of side chains or methylation of thiols.

Applications of Lipoic Acid

According to the instructions for use, Alpha lipoic acid preparations have the following indications for use:

• complex therapy of steatohepatitis, intoxications;
• decreased energy metabolism with low blood pressure and anemia;
• to reduce oxidative stress (causes aging) and increase energy;
• chronic pancreatitis of alcoholic origin, cholecystopancreatitis and hepatitis;
• cirrhosis or other dangerous liver diseases in the active stage;
• chronic heart failure;
• viral hepatitis without jaundice;
• poisoning with mushrooms, carbon, carbon tetrachloride, hypnotics, salts of heavy metals (accompanied by acute liver failure);
• to reduce the dose of Prednisolone, ease the withdrawal syndrome;
• complex treatment and prevention of atherosclerosis.

For diabetes

One of the indications for the use of the drug is diabetic polyneuropathy and the prevention of type 1 and type 2 diabetes. In type 1 diabetes, beta cells are destroyed, which leads to decreased insulin secretion. In type 2 diabetes, peripheral tissues show insulin resistance. Both types cause tissue damage due to oxidative stress, increased free radical production, and decreased antioxidant defenses.

Elevated blood glucose levels increase the concentration of dangerous reactive oxygen species, causing complications of diabetes. When using Alpha lipoic acid R (right type) or L (left type, synthesis product), the utilization of glucose in tissues increases and reduces the oxidative process due to its antioxidant properties. This allows the product to be used as a prevention and treatment of diabetes.

For weight loss

Lipoic acid for weight loss is found in dietary supplements. It is combined with B vitamins or carnitine. The process of losing weight is achieved by accelerating metabolism. Unlike other fat-burning weight loss products, thioctic acid improves and activates metabolic processes without disrupting them; it is a natural substance produced by the human body and is therefore non-toxic.

When using the drug according to the instructions, you can avoid dietary restrictions and fasting because it naturally converts fats into energy. The acid relieves the skin of stretch marks, improves overall well-being, lowers blood sugar, and strengthens the function of the stomach and heart. In the process of losing weight, the substance inactivates harmful substances, accelerates the process of burning sugar in the blood, restores the functioning of blood vessels and the liver, and suppresses appetite. To support the complex effect of the product on the body and weight loss, it is recommended to exercise.

In bodybuilding

Thioctic acid is considered one of the most popular supplements among bodybuilders. When used, the fat burning process is launched, which is enhanced by active physical activity. During training, muscles attract nutrients, thereby increasing endurance and effectiveness of exercise. During intense exercise, oxidative stress accumulates in the muscles, and the medication helps reduce it and inhibits the destruction of proteins.

Due to the insulin-like properties of the drug, glycogen preservation processes are stimulated, muscles absorb glucose more fully and quickly. If you combine the medication with creatine, the process of absorption by muscle fibers is accelerated. Another important property of the substance is the breakdown of heat in mitochondria, which enhances thermogenesis and increases energy expenditure, serving as a powerful fat burner.

How to take Lipoic acid

The instructions for use of the drug indicate the method of administration and dosage, which depend on the form of release prescribed by the doctor. The tablets are taken orally, the solution is intended for injection. The dosage is determined based on the individual characteristics of the patient, as is the course of treatment with the medication. Do not exceed the daily dose of the medicine to avoid overdose symptoms.

Pills

A single dose when taking the drug orally cannot exceed 600 mg, but cannot be less than 25 mg. The tablets are taken after meals, washed down with a small amount of water. The average dose for adults will be 0.05 g 3-4 times/day, for children over six years old - 0.012-0.024 2-3 times/day. The course of treatment, according to the instructions, lasts 20-30 days. If desired, it can be repeated after a month.

To enhance the weight loss effect, it is recommended to take the tablets before or immediately after breakfast, after training or with your last meal. According to reviews, it is advisable to combine the intake with carbohydrate foods (dates, pasta, cereals, bread, legumes). If desired, it is good to combine the medicine with L-carnitine (an amino acid related to B vitamins, necessary for activating fat metabolism), which helps to quickly consume fat energy.

Solution

According to the instructions, the solution is administered intravenously, in a slow stream or drip, with a daily dose of 300-600 mg. It is allowed to administer 2-4 ml of a 0.5% solution (0.01-0.02 g) once a day intramuscularly. The average course of treatment will be 20-30 days; if desired, it can be repeated after a month. Children's dosage aged 2-7 years will be 2 ml at a time, 7-12 years - 4 ml.

special instructions

The instructions for use of the drug indicate that during treatment they need to be careful when driving vehicles and dangerous mechanisms, since the substance reduces the speed of psychomotor reactions and concentration. When treating patients with diabetes with medication, it is necessary to determine the concentration of glucose in the blood more often and reduce the dose of antidiabetic drugs if necessary.

During pregnancy

The drug is prohibited while carrying a child. Its use during pregnancy is possible if the attending physician determines that the expected effect of therapy exceeds the potential risk to the fetus. The drug is included in the FDA group, characterized by uncertain effects on the newborn. When breastfeeding, the product is prohibited.

In childhood

According to the instructions for use, there is little information about the effect of the acid medication on the children's body. Tablets are contraindicated for children under six years of age; solutions for intravenous and intramuscular administration are contraindicated for children under two years of age. Before children use the drug, parents should consult a pediatrician to determine possible negative reactions.

With alcohol

The combination of medication and ethanol is unacceptable throughout the entire course of treatment. This is due to the fact that drinking alcohol weakens the effectiveness of the active substance. In addition, alcohol and alcohol-containing drinks and medications increase the toxic effect on the liver, leading to its destruction, prolonging the time it takes to remove the drug from the body and increasing the risk of overdose.

Drug interactions

The instructions for use indicate drug interactions between the drug and other medications:

• enhances the hypoglycemic effect of doses of insulin and oral hypoglycemic agents;
• reduces the effectiveness of Cisplatin, enhances the anti-inflammatory effect of glucocorticoids;
• binds metals, therefore it is taken at intervals of two hours when combined with preparations of iron, magnesium, calcium;
• the solution is incompatible with glucose, Ringer's solution, compounds that react with disulfide groups and alcohol.

Side effects

When taking the drug, side effects indicated in the instructions may occur:

• with rapid intravenous administration of the solution: diplopia, convulsions, pinpoint hemorrhages in the mucous membranes and skin, increased intracranial pressure;
• when taking pills: nausea, vomiting, heartburn, urticaria;
• for both forms of release: anaphylactic shock, hypoglycemia

Overdose

In case of overdose, irritation of the mucous membranes of the digestive tract may occur, leading to vomiting and diarrhea. If a dose of 10-40 g is accidentally or intentionally ingested into the body along with alcohol, signs of intoxication appear, including death. The patient has psychomotor agitation, dizziness, convulsions, and develops lactic acidosis.

The consequences are hypoglycemia, shock, suppression of the bone marrow, blood vessels, and failure of internal organs. In case of acute poisoning, immediate hospitalization with detoxification is indicated. The patient is induced to vomit, the stomach is washed, artificial respiration is given if necessary, and activated charcoal is given. If seizures occur, symptomatic therapy is used.

Contraindications

The instructions for use of the drug indicate contraindications for which its use is prohibited:

• pregnancy (with caution), breastfeeding;
• hypersensitivity to thioctic acid or additional component composition;
• children up to six years of age for the use of tablets and up to two years for the infusion solution.

Terms of sale and storage

Tablets are available without a prescription, solution - with permission from a doctor. Both drugs are stored in a dry place, protected from light and children, at a temperature of up to 25 degrees for the tablet form and up to 15-20 degrees for the solution. Shelf life is three years.

Analogs

There are no direct analogues of the medicine on the shelves of Russian pharmacies. Possible substitutes that exhibit a similar effect and contain an active substance with different additions are the following domestic and foreign drugs:

• Neurolipon;
• Thiogamma;
• Thiolepta;
• Octolipen;
• Lipothioxone;
• Berlition;
• Thioctacid.

Price

You can buy drugs via the Internet or pharmacies at a cost whose level depends on the chosen form of release of the medicine and the trade markup of the enterprises. Approximate prices for medicines in Moscow and St. Petersburg will be:

Video

Lipoic acid Film-coated tablets 25 mg - polymer jar (jar) 60, cardboard box (box) 36 - No. LSR-006275/08, 2009-11-16 from Uralbiopharm OJSC (Russia)

Latin name

Lipoic acid

Active substance

Thioctic acid

ATX

A16AX01 Thioctic acid

Pharmacological groups

HepatoprotectorsOther lipid-lowering agents

Nosological classification (ICD-10)

B18.8 Other chronic viral hepatitis E78.5 Hyperlipidemia, unspecified K74 Fibrosis and cirrhosis of the liver K76.0 Fatty degeneration of the liver, not elsewhere classified T56 Toxic effect of metals T62.0 In eaten mushrooms Description of the active substance. The scientific information provided is general and cannot be used to make a decision about the possibility of using a particular drug.

Indications of the drug

Parenteral, orally 300 and 600 mg: diabetic and alcoholic polyneuropathy.

Orally 12 and 25 mg: fatty liver, liver cirrhosis, chronic hepatitis, hepatitis A, intoxication (including salts of heavy metals), poisoning with toadstool, hyperlipidemia (including with the development of coronary atherosclerosis - treatment and prevention ).

Contraindications

Hypersensitivity, children under 6 years of age (up to 18 years in the treatment of diabetic and alcoholic polyneuropathy).

Use during pregnancy and breastfeeding

During pregnancy, it is possible if the expected effect of therapy exceeds the potential risk to the fetus.

Breastfeeding should be stopped during treatment.

Side effects

From the gastrointestinal tract: when taken orally - nausea, vomiting, abdominal pain, diarrhea.

Allergic reactions: skin rash, itching, urticaria, anaphylactic shock.

Other: headache, impaired glucose metabolism (hypoglycemia) - with rapid intravenous administration - short-term delay or difficulty breathing, increased intracranial pressure, convulsions, diplopia, pinpoint hemorrhages in the skin and mucous membranes and a tendency to bleeding (due to impaired platelet function ).

Precautionary measures

During the treatment period, regular monitoring of blood glucose concentrations (especially at the beginning of therapy) in patients with diabetes mellitus is necessary. Patients are advised to refrain from drinking alcoholic beverages during treatment.

Storage conditions for the drug Lipoic acid

In a dry place, protected from light, at a temperature not exceeding 25 °C.

Keep out of the reach of children.

Shelf life of the drug Lipoic acid

3 years.

Other packaging options for the drug are Lipoic acid.

Lipoic acid Substance-powder-bag (bag) double-layer polyethylene 18 kg, cardboard drum 1- No. P N000060/01, 2006-05-05 from Marbiopharm (Russia) Lipoic acid Substance-powder-bag (bag) double-layer polyethylene 1 kg, tin can (jar) 1- EAN code: 4602876000656- No. Р N000060/01, 2006-05-05 from Marbiopharm (Russia) Lipoic acid Substance-powder- bag (bag) double-layer polyethylene 5 kg, tin can (jar) 1- No. Р N000060/01, 2006-05-05 from Marbiopharm (Russia) Lipoic acid Substance-powder - double-layer polyethylene bag (bag) 1 kg - No. LSR-007948/08, 2008-10-08 from POLYSAN (Russia) - manufacturer : Polysynthesis (Russia) Lipoic acid Substance-powder - double-layer polyethylene bag (bag) 5 kg - No. LSR-007948/08, 2008-10-08 from POLYSAN (Russia) - manufacturer: Polysynthesis (Russia) Lipoic acid Substance-powder- double-layer polyethylene bag (bag) 10 kg - No. LSR-007948/08, 2008-10-08 from POLYSAN (Russia) - manufacturer: Polisintez (Russia) Lipoic acid Substance-powder - double-layer polyethylene bag (bag) 15 kg - No. LSR -007948/08, 2008-10-08 from POLYSAN (Russia) - manufacturer: Polisintez (Russia) Lipoic acid Film-coated tablets 12 mg - can (jar) 50, cardboard pack 1 - No. P N001574/01, 2007-05 -10 from Marbiopharm (Russia) Lipoic acid Film-coated tablets 25 mg - contour strip packaging 10, cardboard pack 5 - EAN code: 4602876000120- No. P N001574/01, 2007-05-10 from Marbiopharm (Russia) Lipoic acid Tablets, coated 12 mg - contour pack 10, cardboard pack 5 - EAN code: 4602876001653- No. P N001574/01, 2007-05-10 from Marbiopharm (Russia) Lipoic acid Film-coated tablets 12 mg - jar (jar) 100, cardboard pack 1- No. P N001574/01, 2007-05-10 from Marbiopharm (Russia) Lipoic acid Film-coated tablets 25 mg - jar (jar) 50, cardboard pack 1- No. P N001574/01, 2007-05-10 from Marbiopharm (Russia) Lipoic acid Coated tablets 25 mg - can (jar) 100, cardboard pack 1 - EAN code: 4602876003114- No. P N001574/01, 2007-05-10 from Marbiopharm (Russia) Lipoic acid Coated tablets coated 12 mg - polymer jar (jar) 50, cardboard pack 1 - EAN code: 4602876003091- No. P N001574/01, 2007-05-10 from Marbiopharm (Russia) Lipoic acid Coated tablets 25 mg - polymer jar (jar) 50, cardboard pack 1- No. P N001574/01, 2007-05-10 from Marbiopharm (Russia) Lipoic acid Film-coated tablets 25 mg - polymer jar (jar) 100, cardboard pack 1 - EAN code: 4602876003107- No. P N001574 /01, 2007-05-10 from Marbiopharm (Russia)Lipoic acid Film-coated tablets 25 mg - polymer jar (jar) 10, cardboard pack 1- No. LSR-006275/08, 2009-11-16 from Uralbiopharm OJSC (Russia ) Lipoic acid Film-coated tablets 25 mg - polymer jar (jar) 100, cardboard pack 1- No. LSR-006275/08, 2009-11-16 from Uralbiopharm OJSC (Russia) Lipoic acid Film-coated tablets 25 mg - jar ( jar) polymer 20, cardboard pack 1- No. LSR-006275/08, 2009-11-16 from Uralbiopharm OJSC (Russia) Lipoic acid Film-coated tablets 25 mg - polymer jar (jar) 30, cardboard pack 1- No. LSR- 006275/08, 2009-11-16 from Uralbiopharm OJSC (Russia) Lipoic acid Film-coated tablets 25 mg - polymer jar (jar) 40, cardboard pack 1 - No. LSR-006275/08, 2009-11-16 from Uralbiopharm OJSC (Russia) Lipoic acid Film-coated tablets 25 mg - polymer jar (jar) 50, cardboard pack 1- No. LSR-006275/08, 2009-11-16 from Uralbiopharm OJSC (Russia) Lipoic acid Film-coated tablets 25 mg - polymer jar (jar) 60, cardboard pack 1- No. LSR-006275/08, 2009-11-16 from Uralbiopharm OJSC (Russia) Lipoic acid Film-coated tablets 25 mg - contour cell packaging (polymer-coated paper/PVC) 10 , cardboard pack 1- No. LSR-006275/08, 2009-11-16 from Uralbiopharm OJSC (Russia) Lipoic acid Film-coated tablets 25 mg - contour cell packaging (polymer-coated paper/PVC) 10, cardboard pack 2- No. LSR-006275/08, 2009-11-16 from Uralbiopharm OJSC (Russia) Lipoic acid Film-coated tablets 25 mg - contour cell packaging (polymer-coated paper/PVC) 10, cardboard pack 3 - No. LSR-006275/08, 2009-11-16 from Uralbiopharm OJSC (Russia) Lipoic acid Film-coated tablets 25 mg - contour cell packaging (polymer-coated paper/PVC) 10, cardboard pack 4 - No. LSR-006275/08, 2009-11-16 from Uralbiopharm OJSC (Russia) Lipoic acid Film-coated tablets 25 mg - contour strip packaging (polymer-coated paper/PVC) 10, cardboard pack 5 - EAN code: 4603179003351 - No. LSR-006275/08, 2009-11-16 from Uralbiopharm OJSC (Russia) Lipoic acid Film-coated tablets 25 mg - contour cell packaging (polymer-coated paper/PVC) 10, cardboard pack 6 - No. LSR-006275/08, 2009-11-16 from Uralbiopharm OJSC (Russia) Lipoic acid Film-coated tablets