What is Reamberin used for? Why is Reamberin prescribed? Optimal daily dosage

Reamberin has antihypoxic and antioxidant effects, having a positive effect on aerobic processes in the cell, reducing the production of free radicals and restoring the energy potential of cells. The drug activates the enzymatic processes of the Krebs cycle and promotes the utilization of fatty acids and glucose by cells, normalizes the acid-base balance and gas composition of the blood. Has a moderate diuretic effect.

Pharmacokinetics

When administered intravenously, the drug is quickly utilized and does not accumulate in the body.

Indications for use

Reamberin is used in adults and children from 1 year of age as an antihypoxic and detoxifying agent for acute endogenous and exogenous intoxications of various etiologies.

Directions for use

Side effects

With rapid administration of the drug Reamberin, undesirable effects are possible, classified according to their frequency of development as follows:

General disorders and disorders at the injection site: very rarely - hyperthermia, chills, sweating, weakness, pain at the injection site, edema, hyperemia, phlebitis.

Immune system disorders: very rarely - allergic reactions, angioedema, anaphylactic shock.

Disorders of the skin and subcutaneous tissues: very rarely - allergic rash, urticaria, itching.

Disorders of the respiratory system, chest and mediastinal organs: very rarely - shortness of breath, dry cough.

Cardiac disorders: very rarely - tachycardia, palpitations, shortness of breath, pain in the heart, chest pain.

Vascular disorders: very rarely - arterial hypotension/hypertension, short-term reactions in the form of a burning sensation and redness of the upper body. Gastrointestinal disorders: very rarely - nausea, vomiting, metallic taste in the mouth, abdominal pain, diarrhea.

Nervous system disorders: very rarely - dizziness, headache, convulsions, tremor, paresthesia, agitation, anxiety.

If any of the undesirable effects indicated in the instructions get worse or you notice any other undesirable effects not listed in the instructions, tell your doctor.

Contraindications

Contraindications to the use of the drug Reamberin are: individual intolerance, a condition after a traumatic brain injury, accompanied by cerebral edema, acute renal failure, chronic kidney disease (stage 5, glomerular filtration rate less than 15 ml/min), pregnancy, during breastfeeding.

With caution: with alkalosis, renal failure.

Pregnancy

The use of Reamberin during pregnancy and breastfeeding is contraindicated due to the lack of clinical studies in these groups of patients.

Interaction with other drugs

Combines well with antibiotics, water-soluble vitamins, and glucose solution. It is not recommended to mix the drug in a bottle or container with other medications.

Intravenous administration of the drug Reamberin simultaneously with calcium supplements is unacceptable due to possible precipitation of calcium succinate.

Overdose

Arterial hypotension may occur, which requires stopping the infusion of the drug Reamberin, and, if necessary, the introduction of hypertensive drugs, cardiac drugs, calcium chloride, polyglucin.

Storage conditions

Reamberin should be stored in a place protected from light at a temperature of 0 to 25 ° C. Freezing of the drug is allowed.

If the color of the solution changes or there is a precipitate, the use of the drug is unacceptable. Keep out of the reach of children.

Release form

Reamberin - solution for infusion 1.5%.

100 and 200 ml in glass bottles with a capacity of 125 and 250 ml, respectively, or 400 ml in glass bottles with a capacity of 450 or 500 ml, sealed with rubber stoppers, crimped with aluminum caps or caps combined with aluminum and plastic. Each bottle, along with instructions for medical use, is placed in a cardboard pack.

The number of instructions for medical use is equal to the number of primary packaging in a group container.

Compound

Reamberin contains the active component: meglumine sodium succinate 15.00 g obtained according to the following recipe: N-methylglucamine (meglumine) 8.725 g; Succinic acid 5.280 g.

Excipients: Sodium chloride 6.00 g, Potassium chloride 0.30 g, Magnesium chloride (in terms of anhydrous) 0.12 g, Sodium hydroxide 1.788 g, Water for injection up to 1.0 l.

Ionic composition per 1 l: sodium ion 147.2 mmol, potassium ion 4.0 mmol, magnesium ion 1.2 mmol, chloride ion 109.0 mmol, succinate ion 44.7 mmol, N-methylglucammonium- ion 44.7 mmol.

In case of poisoning, drug and infectious intoxication, alcohol overdose, ischemia and hypoxia, Reamberin helps, the instructions for use of which indicate that the drug promotes self-cleansing of the body from toxins, protects the cardiovascular and nervous system from their effects. The Reamberin dropper does not replace diseased cells, but stimulates their independent restoration and cleansing.

The drug is created on the basis of succinic acid. The main active ingredient is sodium meglumine succinate (15 g).

Other active ingredients:

sodium chloride (6 g);
potassium chloride (0.3 g);
magnesium chloride (0.12 g);
caustic soda (1.788 g);
water (up to a liter).

The medication is a clear, colorless, odorless liquid (1.5%) for infusion through a dropper. Sold in glass bottles of 100, 200 and 400 ml, packed in a box, and in hospital bags (Reamberin 250 and 500 ml). The packages are placed in large boxes (20 or 32 IV bags).

Taking the medication orally is not dangerous, but it will not work because the drug acts at the cellular level. Only intravenous administration is advisable.

Pharmacological action

Pharmacological group - detoxification agents. Reamberin is a carefully selected and ion-calculated solution. It has antioxidant and antihypoxic properties. The components of the drug complement and enhance each other's effects. Due to which the metabolism in the body is restored in a short time. The medicine is used for intoxication of all types and forms. The medication has undergone laboratory and clinical studies and has proven its effectiveness. The product quickly leaves the body, substances do not accumulate in cells (the color of urine may change).

The product removes toxins, stabilizes the energy balance in cells, helps in the breakdown of fats and sugar, enhances the anaerobic process in cells, and prevents the production of free radicals. The medicine restores the acid-base and water-electrolyte balance, normalizes blood composition. Positively affects the functioning and condition of the brain, liver, kidneys, heart, and nervous system. The active substances of the drug find the affected cells and promote their regeneration.

Why is Reamberin prescribed?

The medicine is prescribed for intoxication of various etiologies, oxygen starvation, impaired blood circulation and oxygen metabolism, and dehydration. The medicine is used in pediatrics and therapy. It has antihypoxic and antioxidant effects and provides a mild diuretic effect.

For what diagnoses and conditions is the solution prescribed:

psoriasis, dermatitis and other skin infections;
large blood losses;
disruptions in hematopoiesis and blood flow;
heart attack;
recovery after surgery;
chronic hepatitis, jaundice;
poisoning;
alcohol intoxication;
drug poisoning;
food poisoning;
weakening of brain, heart, liver and kidney cells;
hypoxia;
burns;
cholestasis;
state of shock;
necrotic blockage of blood vessels;
adaptation and increase in endurance in athletes;
therapy and prevention of fatigue.

Sometimes a medicine is prescribed after anti-cancer treatment in order to normalize the patient’s condition and well-being and protect healthy cells from the aggressive substances of chemotherapy. Reamberin is not prescribed directly during anticancer therapy.

According to patient reviews, the medicine helps to quickly recover from long-term infections or after alcohol poisoning. In combination with other medications, it accelerates the healing process for pathologies of the nervous or cardiovascular system. Suitable for prevention when working in hazardous industries or under increased physical activity.

Contraindications and precautions

Diagnoses and conditions for which taking Reamberin is prohibited:

cerebral edema caused by a recent traumatic brain injury;
liver and kidney diseases;
the period of bearing a child (due to insufficient knowledge);
breastfeeding (due to insufficient knowledge);
allergy to the composition.

In rare cases, Reamberin may be prescribed to a pregnant woman, provided that the intended benefit to the woman outweighs the potential risk to the fetus. Only a doctor can prescribe therapy and select the dosage. Treatment should be carried out under the strict supervision of a physician. Therapy for hepatitis B is unacceptable under any circumstances. Otherwise, you need to stop breastfeeding.

It is necessary to take the medicine with extreme caution during alkalosis. People with diabetes should also take Reamberin with caution and need to regularly measure and monitor changes in glucose levels. The medicine causes low blood sugar, which can worsen the condition of people with initially low glucose levels.

Directions for use and dosage

In pediatrics, the drug is prescribed to children from one year old. The dosage is selected individually at the rate of 6-10 ml per kilogram. The medication is prescribed once a day, at a rate of 3-4 ml per second. The total volume is divided into two doses and dripped at intervals of 7-10 hours. The maximum daily norm is 400 ml.

In rare cases, with the permission of a doctor, the drug can be prescribed to a child up to one year old, for example, in case of prematurity or hypoxia during childbirth. In this case, the dosage is selected at the rate of 2-5 ml per kilogram at a rate of 2.5-6 ml per hour.

When treating adults, the dosage is selected at the rate of 10 ml per kilogram. The infusion rate is selected individually, but not more than 1-4.5 ml per minute (90-95 drops per minute). When treating elderly clients, you must first set the minimum drip frequency - 1-2 ml per minute. In case of shock, the rate of administration is 1-1.5 ml per minute. The maximum daily norm is from 300 to 900 ml. In rare cases, when recovering from an extremely serious condition, the daily volume can be increased to 2 liters. For viral hepatitis, the daily dosage is 200-400 ml.

The general course of treatment and the specifics of the appointment depend on the severity of the disease and the general condition of the client. The average course of treatment for patients over 18 years of age is 11 days, for pediatric patients - 5 days. When treating skin infections, a course of treatment is prescribed: 2 weeks every 3-4 months.

Side effects and overdose

No cases of overdose have been identified. If the drug is administered incorrectly, side effects from the respiratory, immune, cardiovascular, nervous, digestive, and integumentary systems are observed.

Side effects while taking the medication include (from common to rarely diagnosed complications):

allergies (swelling, anaphylactic shock, rashes, itching);
dyspnea;
frequent yawning;
feeling of lack of oxygen;
difficulty breathing;
dry cough;
chest pain;
immune disorders;
pressure fluctuations;
increased heart rate;
burning sensation in the chest;
redness in the upper parts of the body (a short-term reaction immediately after taking the medicine lasts 5-10 minutes);
nausea;
vomit;
metallic taste;
stool disorder;
abdominal pain;
cephalgia;
dizziness;
convulsions;
tremor;
hyperexcitability;
increased anxiety and restlessness;
hyperhidrosis;
increase in temperature;
chills;
general weakness;
pain at the IV insertion site.

The presence of adverse reactions indicates that the medication was administered too quickly or the dosage was incorrectly selected, or an allergy to the drug. In addition, complications arise due to long-term use of the drug.

If you feel worse, you should consult a doctor. He will adjust the dosage and course of treatment or replace the medicine with an analogue. If you feel unwell immediately during the administration of the medicine, then you need to stop the procedure and, if necessary, carry out symptomatic therapy.

Drug interactions and compatibility with alcohol

It is unacceptable to mix the medication in the same bottle with other medications and take it simultaneously as part of the same therapy with calcium supplements. The drug combines well with vitamins that need to be taken with water or dissolved in it, glucose solution and antibiotics.

Conditions for dispensing from pharmacies

To buy medicine, you need to provide a prescription from a doctor. It is not allowed to use the product outside the hospital.

Shelf life and storage conditions

The medicine is stored in glass bottles for 5 years, in polymer bags - 3 years. During storage, the drug should be kept away from children, moisture and light. It is important to maintain a temperature range from 0 to 25°C. Short-term freezing of the medicine is acceptable, but after the expiration date the medicine is not allowed to be used. In addition, it is unacceptable to use the medication if its color changes or there is sediment at the bottom.

Analogs (briefly)

The drug is produced in Russia. It has both domestic and foreign analogues:

Glyuksil. The composition includes potassium, magnesium, calcium and sodium chloride, sugar, xylitol and sodium acetate. Compared to Reamberin, it has a wider range of indications. Most often prescribed for shock, burns, intoxication, prolonged purulent inflammation, liver disease, and infections.
Xylate. The composition includes sodium, potassium, calcium and magnesium chlorides, xylitol, sodium acetate. Taking the medication is strictly permitted in a hospital setting. It is forbidden to take the drug during pregnancy and during breastfeeding. Most often, the medicine is prescribed for recovery after poisoning, as well as to stimulate local blood circulation, in case of shock (due to injuries, burns, operations, incompatibility of transfused blood), and carbohydrate metabolism disorders.
Sorbilact. This is a regulator of water-salt balance and blood plasma. It is prescribed for shock of any etiology, cerebral edema, infections, gastrointestinal pathologies, operations, liver and kidney diseases. The composition includes sodium, potassium, calcium and magnesium chlorides, sorbidol, sodium lactate. The drug stimulates intestinal activity, has a diuretic and detoxifying effect, stimulates and normalizes energy metabolism in cells.
Meglumine sodium succinate. This is a direct analogue of Reamberin and its international nonproprietary name (INN). You can search for a product by this name. All indications for use and contraindications, composition and properties are similar to Reamberin.

The average price for Reamberin is 600 rubles. The cost of analogues varies from 130 to 4000 rubles.

Reamberin is a medication sold in the form of a solution for infusion. The action of the drug is aimed at detoxification and providing an antihypoxic effect on the patient’s body. Accordingly, it is used for acute intoxications of an exogenous and endogenous nature. The drug is contraindicated for pregnant women and women who are breastfeeding. It can be used in pediatrics; the drug Reamberin is used in children over 1 year of age.

Dosage form

Reamberin is available in the form of a solution for infusion. Sales are carried out in glass bottles of 100, 200, 400 ml. Bottles are packed in cardboard boxes. The product is also available in containers made of multilayer polyolefin film of 250 and 500 ml. They are packaged in boxes of 20 or 32 pieces for hospitals.

Description and composition

Reamberin solution is a colorless liquid that is transparent.

The active component in the drug is sodium meglumine succinate.

The medication also contains a number of components that serve as additional components. These include:

sodium chloride;
potassium chloride;
magnesium chloride;
sodium hydroxide;
water for injections.

Pharmacological group

The active component of the drug has antioxidant and antihypoxic properties. The substance has a beneficial effect on cellular anaerobic processes. This occurs by reducing the production of free radicals and restoring the energy content of cells.

The drug stimulates enzymatic processes in the citrate cycle. The effect of the substance is noted, which manifests itself in promoting the process of excretion of glucose and fatty acids.

Withdrawal of the product occurs very quickly. There is no accumulation of the substance.

Indications for use

The drug Reamberin is used in patients according to the indications of the treating specialist.

for adults

Indications for the use of the drug Reamberin are acute intoxications of an endogenous and exogenous nature.

for children

Reamberin infusions are used in children over one year of age to achieve detoxification and antihypoxic effects in acute exogenous and endogenous intoxications.

Due to the insufficient number of clinical studies on the use of Reamberin in pregnant women, as well as in those who are in the lactation period, the use of droppers in these categories of patients is unacceptable.

Contraindications

There are a number of conditions, the presence of which in a patient obliges the doctor to refrain from prescribing the specified medication to the patient; these include for Reamberin:

acute renal failure;
period of bearing a child;
recent traumatic brain injury with associated cerebral edema;
kidney disorders of chronic etiology;
special individual hypersensitivity to any of the components of the product;
lactation period.

In case of renal failure and alkalosis, Reamberin should be used with great caution.

Applications and dosages

The drug is administered by drip. Reamberin is subject to intravenous administration.

The doctor determines the rate of administration of the medication and the required dosage. The treating specialist makes these decisions based on the patient's condition.

for adults

The rate of administration of the substance for adult patients should not be more than 90 drops per minute (1-4.5 ml per minute). The average daily dose is 10 ml per kilogram of body weight.

The use of the drug in elderly patients and patients with renal failure should be carried out with caution. It may be necessary to reduce the rate of administration for elderly patients.

for children

For children over 1 year of age, Reamberin infusion solution is administered intravenously by drip in a dosage of 6 to 10 ml per kilogram of body weight. Administration is carried out once a day. The rate should be 3 to 4 ml per minute. The daily dosage of the drug Reamberin for children is no more than 400 ml.

The duration of the course of drug therapy is no more than 11 days.

for pregnant women and during lactation

The lack of studies proving the safety of Reamberin use in pregnant and lactating women makes it impossible to administer the infusion solution to these categories of patients.

Side effects

Side effects of Reamberin are very unlikely and are extremely low in frequency. Among the actions that may occur during the use of the medication are the following:

allergic reactions;
rash;
dyspnea;
tachycardia;
nausea;
dizziness;
hyperthermia;
Quincke's edema;
dry cough;
anaphylactic shock;
pain in the heart area;
excitation;
headache;
chills;
increased blood pressure;
metallic taste in the mouth;
sweating;
convulsions;
lowering blood pressure;
pain in the abdominal area;
diarrhea;
edema;
pain at the injection site;
lethargy;
tremor;
hyperemia;
anxiety;
phlebitis;
paresthesia.

If the above reactions occur in the patient, the rate of administration of the drug is reduced.

Interaction with other drugs

In general, the drug Reamberin is well compatible.

It can be administered simultaneously with a glucose solution or water-soluble vitamins or antibiotics.

Mixing the product with other solutions and medicinal substances is unacceptable.

Also, you should not combine the use of Reamberin with the administration of calcium supplements, since there is a possibility of calcium succinate precipitating.

Special instructions

The medication stimulates anaerobic processes, as a result of which the level of glucose in the blood may decrease, and there is also the possibility of an alkaline urine reaction.

Patients suffering from this should be treated with caution; in this group, blood glucose levels should be monitored.

If during storage the color of the product changes or a precipitate forms, then the use of this solution seems impossible.

During therapy with Reamberin, driving vehicles or other potentially dangerous mechanisms is not recommended.

Overdose

There is no information about cases of overdose. However, there is a possibility of intensifying side effects with long-term treatment with Reamberins in high dosages.

Storage conditions

The medicine should be stored in a dark place inaccessible to children. Storage temperature can vary from 0 to 25 degrees Celsius. It is possible to freeze the Reamberin solution.

The shelf life of the product in the form of release in glass bottles is 5 years, and when sold in polymer containers, this period is 3 years from the date of release.

Use after the expiration date is impractical and dangerous.

The drug is dispensed with the need to present a prescription from a doctor.

Analogs

There are a number of other IV solutions that produce a similar effect.

The active ingredients of the product include potassium chloride, magnesium chloride, calcium chloride, sodium chloride, glucose, xylitol and sodium acetate. The medication has a more extensive list of indications for use. Glyxil is used to normalize the acid-base balance in conditions of shock, burns and intoxications, long-term purulent lesions, liver disorders, as well as various infectious lesions.

The list of active substances in Xylate includes potassium chloride, xylitol, magnesium chloride, calcium chloride, sodium chloride and sodium acetate. Used only for inpatient therapy. Pregnancy is a contraindication to the use of the product. The drug Xylate, like Reamberin, is used to reduce intoxication, but also has a list of other indications, such as improving microcirculation, to replenish carbohydrate deficiency that occurs in other pathologies of glucose elimination, in traumatic, hemolytic, surgical and burn shock and in some other cases.

Meglumine calcium succitate

This remedy is a direct analogue of Reamberin. This drug is used for intoxication and has properties similar to Reamberin. Not used during pregnancy and lactation.

Price

The cost of Reamberin is on average 650 rubles. Prices range from 131 to 4298 rubles.

Intoxication of the body with harmful substances accompanies us everywhere. This includes poor nutrition, ecology, viral, infectious, and autoimmune diseases. It is very important to detoxify the body in a timely manner. Otherwise, complications may develop, including death.

One of the effective drugs for detoxification is Reamberin. Instructions for use of the drug indicate that it is used to treat the liver, kidneys, heart, and infectious pathologies. It is important to note that Reamberin is available exclusively in the form of a solution for intravenous administration. Therefore, therapy is carried out within the walls of the clinic.

The product is available in the form:

solution for infusion 1.5%; glass bottle (bottle) 400 ml box (box);
solution for infusion 1.5%; glass bottle (bottle) 200 ml box (box);
solution for infusion 1.5%; polymer container 250 ml;
solution for infusion 1.5%; polymer container 500 ml;
solution for infusion 1.5%; glass bottle (bottle) 100 ml box (box).

The composition of the drug includes:

Among the auxiliary agents, sodium hydroxide is noted - 1.788 g, water for liquid - up to 1 liter.

Pharmacological action

A drug with a detoxification effect for parenteral use. It has antihypoxic and antioxidant effects, having a positive effect on aerobic processes in the cell, reducing the production of free radicals and restoring the energy potential of cells.

The drug activates the enzymatic processes of the Krebs cycle and promotes the utilization of fatty acids and glucose by cells, normalizes the acid-base balance and gas composition of the blood. Has a moderate diuretic effect.

Worth knowing! The only possible way to use the drug Reamberin is a dropper.

This pharmacological agent belongs to complex drugs with a large number of medicinal properties:

detoxification effect;
antihypoxic effect;
antioxidant effect;
nephro-, cardio- and hepatoprotective effect;
inhibition of fat peroxidation under conditions of hypoxia or tissue ischemia;
stimulation of antioxidant enzyme protection;
stabilize the membranes of brain, liver, kidney, and heart cells;
increasing the compensatory capabilities of glycolysis;
stimulation of liver cell regeneration;
activation of reparative processes during cardiac muscle infarction;
diuretic effect.

All these functions make the scope of the medicine very wide, it includes various types of intoxication of the body, liver disease, kidney disease, heart disease, and internal infections.

Indications for use

Reamberin is used in adults and children from 1 year of age as an antihypoxic and detoxifying agent for acute endogenous and exogenous intoxications of various etiologies.

The drug is prescribed when detoxification is necessary:

early period after traumatic operations;
severe blood loss;
anesthesia;
acute respiratory failure;
acute heart failure;
ischemic-hypoxic lesions of vital organs;
intoxication of any etiology, including endogenous intoxication;
circulatory disorders;
poisoning with xenobiotic substances.

The drug is effective as a therapy for cholestasis, toxic hepatitis, protracted forms of hepatitis of viral etiology with icteric syndrome (as a component of complex treatment). In general, Reamberin is used to treat any liver disease, including psoriasis and helminthiasis.

Contraindications

The drug is contraindicated for use in the following cases:

condition after a traumatic brain injury, accompanied by cerebral edema;
severe renal dysfunction;
pregnancy;
lactation;
hypersensitivity to the components of the drug.

Applications and dosages

The rate of drug administration and dose are determined in accordance with the patient's condition. The duration of the course of drug administration depends on the severity of the patient’s condition, but not more than 11 days.

Worth knowing! Reamberin is administered intravenously at a rate of no more than 90 drops/min.

For adults

For adults, the maximum daily dose of the solution is 2 liters. The usual dosage for adults is 400-800 ml per day.

In severe conditions (shock, intoxication, hypoxia), treatment is supplemented with infusion therapy and, if necessary, blood substitutes.

For hepatitis of viral etiology, adults are recommended 200-400 ml per day for 2 to 10 days. At the same time, blood serum is regularly examined to determine hepatocyte cytolysis enzymes.

For psoriasis, Reamberin is used for a long time - 400 ml of the medicine must be used for 10-14 days. It is recommended to take several such courses per year with a break of 3-4 months between them.

For children

For children over 1 year of age, the drug is administered at a rate of 10 ml/kg body weight once a day at a rate of no more than 60 drops per minute (3 ml/min).

For pregnant women and during lactation

The drug is contraindicated for use during pregnancy and lactation.

Side effects and overdose

Among the adverse reactions the following are noted:

metallic taste in the mouth;
allergic reactions (itching, burning, urticaria);
redness of the upper half of the body and a feeling of heat in case of rapid administration (temporary side effect);
shortness of breath, tachycardia, cough;
a sharp decrease or increase in blood pressure;
Dizziness, nausea, vomiting;
cramps, swelling;
anaphylactic shock.

With excessive use of the drug, negative phenomena may appear, expressed in the form of a sharp decrease in blood pressure. In order to eliminate the consequences, you need to stop taking the drug and carry out proper treatment.

Special instructions

Due to the activation of aerobic processes in the body by the drug, alkalization of the blood and urine is possible. If the color of the solution changes or there is a precipitate, the use of the drug is unacceptable.

Interaction with other drugs

Combines well with antibiotics, water-soluble vitamins, and glucose solution.

Storage conditions

The drug should be stored out of the reach of children, protected from light at a temperature of 0° to 25°C. Freezing of the drug is allowed. Shelf life - 3 years.

Important! If the color of the solution changes or there is a precipitate, the use of the drug is unacceptable.

Analogs and price

There are a number of other solutions for droppers that produce a similar effect:

Gluxil
Among The active ingredients of the product are potassium chloride, magnesium chloride, calcium chloride, sodium chloride, glucose, xylitol and sodium acetate. The medication has a more extensive list of indications for use. Glyxil is used to normalize the acid-base balance in conditions of shock, burns and intoxications, long-term purulent lesions, psoriasis, liver disorders, as well as various infectious lesions.
Xylate
List Xylate's active ingredients include potassium chloride, xylitol, magnesium chloride, calcium chloride, sodium chloride and sodium acetate. Used only for inpatient therapy. Pregnancy and lactation are contraindications to the use of the product. The drug Xylate, like Reamberin, is used to reduce intoxication, but also has a list of other indications, such as improving microcirculation, to compensate for the deficiency of carbohydrates that occurs in diabetes mellitus and other pathologies of glucose elimination, in traumatic, hemolytic, surgical and burn shock and in some other cases.
Meglumine calcium succitate
This remedy is a direct analogue of Reamberin. This drug is used for intoxication and has properties similar to Reamberin. Not used during pregnancy and lactation.

The cost of Reamberin is on average 650 rubles. Prices range from 131 to 4298 rubles.

REAMBERIN (form - solution) belongs to the group of plasma replacement and perfusion solutions. The instructions for use highlight the following features:

Sold only with a doctor's prescription
During pregnancy: contraindicated
When breastfeeding: contraindicated
In childhood: with caution
If renal function is impaired: contraindicated

Package

Compound:

Active ingredient:
Meglumine sodium succinate	15.00 g
obtained according to the following formula:
N-methylglucamine (meglumine)	8.725 g
Succinic acid	5.280 g
Excipients:
Sodium chloride	6.00 g
Potassium chloride	0.30 g
Magnesium chloride (calculated as anhydrous)	0.12 g
Sodium hydroxide	1.788 g
Water for injections	up to 1.0 l
Ionic composition per 1 l:
sodium ion	147.2 mmol
potassium ion	4.0 mmol
magnesium ion	1.2 mmol
chloride ion	109.0 mmol
succinate ion	44.7 mmol
N-methylglucammonium ion	44.7 mmol
Osmolality 313 mOsm/kg

Description:

transparent colorless liquid.

Pharmacotherapeutic group:

solutions affecting water-electrolyte balance.

ATX code:

Pharmacological properties

Pharmacodynamics

Reamberin ® has an antihypoxic and antioxidant effect, having a positive effect on aerobic processes in the cell, reducing the production of free radicals and restoring the energy potential of cells. The drug activates the enzymatic processes of the Krebs cycle and promotes the utilization of fatty acids and glucose by cells, normalizes the acid-base balance and gas composition of the blood. Has a moderate diuretic effect.

Pharmacokinetics

When administered intravenously, the drug is quickly utilized and does not accumulate in the body.

Indications for use:

Reamberin ® is used in adults and children from 1 year of age as an antihypoxic and detoxifying agent for acute endogenous and exogenous intoxications of various etiologies.

Contraindications:

Individual intolerance, condition after traumatic brain injury, accompanied by cerebral edema, acute renal failure, chronic kidney disease (stage 5, glomerular filtration rate less than 15 ml/min), pregnancy, during breastfeeding.

With caution

With alkalosis, renal failure.

Use during pregnancy and breastfeeding

The use of Reamberin ® during pregnancy and breastfeeding is contraindicated due to the lack of clinical studies in these groups of patients.

Directions for use and doses

For adults: administered intravenously at a rate of 1-4.5 ml/min (up to 90 drops per minute). The average daily dose is 10 ml/kg. The course of therapy is up to 11 days.

For children: administered intravenously at a rate of 6-10 ml/kg per day at a rate of 3-4 ml/min. The course of therapy is up to 11 days.

Use in elderly patients

No studies have been conducted in elderly patients. In this regard, the use of the drug should be started with a slower rate of administration: 30-40 drops (1-2 ml) per minute.

Use in patients with renal failure

No studies have been conducted in patients with renal failure. In this regard, it is recommended to exercise caution when using the drug in such patients.

Use for alkalosis

If decompensated alkalosis is detected, the use of the drug should be discontinued until the acid-base state of the blood normalizes.

Side effect

With rapid administration of the drug, undesirable effects are possible, classified according to their frequency of development as follows:

– very often (≥1/10);

– often (from ≥1/100 to<1/10);

– uncommon (from ≥1/1000 to<1/100);

– rarely (from ≥1/10000 to<1/1000);

- very rarely (<1/10000);

– frequency unknown (frequency cannot be determined based on available data).

General disorders and disorders at the injection site: very rarely - hyperthermia, chills, sweating, weakness, pain at the injection site, edema, hyperemia, phlebitis.

Immune system disorders: very rarely - allergic reactions, angioedema, anaphylactic shock.

Disorders of the skin and subcutaneous tissues: very rarely - allergic rash, urticaria, itching.

Disorders of the respiratory system, chest and mediastinal organs: very rarely - shortness of breath, dry cough.

Cardiac disorders: very rarely - tachycardia, palpitations, shortness of breath, pain in the heart, pain in the chest.

Vascular disorders: very rarely - arterial hypotension/hypertension, short-term reactions in the form of a burning sensation and redness of the upper body.

Gastrointestinal disorders: very rarely - nausea, vomiting, metallic taste in the mouth, abdominal pain, diarrhea.

Nervous system disorders: very rarely - dizziness, headache, convulsions, tremor, paresthesia, agitation, anxiety.

If any of the undesirable effects indicated in the instructions get worse or you notice any other undesirable effects not listed in the instructions, tell your doctor.

Interaction with other drugs

Combines well with antibiotics, water-soluble vitamins, and glucose solution. It is not recommended to mix the drug in a bottle or container with other medications.

Intravenous administration of the drug Reamberin ® simultaneously with calcium supplements is unacceptable due to possible precipitation of calcium succinate.

Special instructions

Due to the activation of aerobic processes in the body by the drug, a decrease in the concentration of glucose in the blood and the appearance of an alkaline reaction in urine are possible. In patients with diabetes mellitus or patients with reduced glucose tolerance, periodic monitoring of blood glucose concentrations is required.

Impact on the ability to drive vehicles and machinery

Release form:

Solution for infusion 1.5%.

250 or 500 ml in containers made of multilayer polyolefin film. 32 containers of 250 ml or 20 containers of 500 ml, together with instructions for medical use, are placed in a group container (for hospitals) made of corrugated cardboard. The number of instructions for medical use is equal to the number of primary packaging in a group container.