Sulfadimethoxine is a chemical analogue of para-aminobenzoic acid, a substance vital for bacteria and some protozoa (Toxoplasma) for the synthesis of their DNA.

Sulfadimethoxine is absorbed by bacteria, disrupts the formation of nucleic acids, and as a result, the pathogen cell cannot reproduce and function normally.

The drug is active against gram-positive and gram-negative microorganisms: streptococci, staphylococci, Proteus, Escherichia coli, Klebsiella, Shigella and Salmonella, Vibrio cholerae, gonococcus, Toxoplasma, trachoma pathogen.

Clinical and pharmacological group

Antibacterial agent, sulfanilamide derivative.

Terms of sale from pharmacies

You can buy according to a doctor's prescription.

Price

How much does Sulfadimethoxine cost in pharmacies? The average price is 35 rubles.

Composition and release form

The dosage form of Sulfadimethoxine is tablets: white or white with a creamy tint, flat-cylindrical in shape, with a score and a bevel (in contour cell or cell-free packages of 10 pcs., in a cardboard pack of 1 or 2 packages; in polymer jars of 10 pcs., in 1 can in a cardboard pack; 15 pcs in a plastic case; 20 pcs in dark glass jars, 1 can in a cardboard pack).

Composition of 1 tablet:

• active substance: sulfadimethoxine – 0.2 or 0.5 g;
• auxiliary components (0.2/0.5 g of active ingredient): aerosil (colloidal silicon dioxide) – 0.000 44/0.001 1 g; potato starch of the “Extra” variety – 0.016 92/0.042 3 g; calcium stearate – 0.002 2/0.005 5 g; medical gelatin – 0.000 44/0.001 1 g.

Pharmacological action

The drug is effective against bacterial infections. Its mechanism of action is to inhibit the enzyme glucose-6-dehydrogenase, which is responsible for the synthesis of dihydrofolic acid (a type of folic acid). It is necessary for bacteria to produce purines and pyrimidines, which are part of the cell's DNA. The active substance of the drug stops reproduction, and does not kill encapsulated bacteria that are at rest in the body, and does not cause resistance.

The active component is an analogue of para-aminobenzoic acid, disrupts the metabolism of bacteria and the production of phosphatase enzymes. Sulfadimethoxine inhibits the proliferation of gram-positive staphylococci, streptococci, gram-negative Escherichia coli, Friedlander's bacillus, Klebsiella, pneumococci, dysentery pathogens and other shigellosis infections. The medicine inhibits the growth of chlamydia and has little effect on Proteus.

The drug is detected in the blood half an hour after administration, reaches maximum concentration after 8-12 hours, poorly penetrates the blood-brain barrier, and is therefore ineffective against meningitis (caused by meningococcus) and inflammatory processes of the brain. The active substance of the composition, soon after absorption in the gastrointestinal tract, is found in joint and peritoneal fluid, pleural effusion, and middle ear exudate. The component is metabolized in the liver and is excreted in urine and bile.

Indications for use

What does it help with? Sulfadimethoxine is used to treat infectious and inflammatory diseases (caused by microorganisms sensitive to sulfadimethoxine), such as:

• pyoderma,
• trachoma,
• acute respiratory diseases,
• inflammatory diseases of the urinary and biliary tract,
• dysentery,
• drug-resistant forms of malaria (in combination with antimalarials),
• inflammatory lesions of the central nervous system, wound infections.

Contraindications

According to the instructions, the use of Sulfadimethoxine is contraindicated in the following cases:

• azotemia;
• porphyria;
• pregnancy and lactation (prescription of Sulfadimethoxine is possible only in cases where the expected benefit exceeds the possible harm);
• age up to 3 months;
• thyroid diseases;
• inhibition of bone marrow hematopoiesis;
• congenital deficiency of glucose-6-phosphate dehydrogenase;
• liver/renal failure;
• chronic heart failure;
• individual intolerance to the components of the drug.

Caution when using Sulfadimethoxine (relative contraindications) is required in the presence of the following diseases/conditions:

• anemia with a reduced color index;
• functional disorders of the liver/kidneys;
• folic acid deficiency.

Prescription during pregnancy and lactation

Sulfadimethoxine is extremely undesirable to use during pregnancy and during breastfeeding, since it penetrates well through the placenta and into breast milk, and can cause dyspepsia, liver and kidney dysfunction, kernicterus or hemolytic anemia in the child.

Dosage and method of administration

As indicated in the instructions for use, before starting treatment, it is necessary to check the sensitivity of pathogenic microflora to this medicine. It makes no sense to use sulfadimethoxine in the absence of sensitivity, since the harm caused by the active substance to the body exceeds the benefit from the fight against pathogenic bacteria.

• Adults are prescribed a dose of 1000 mg on the first day, then 500 mg per day. In case of severe infection, it is possible to increase the starting dose to 2 mg, and the daily dose to 1 mg. Take the medicine once a day, after meals. Duration of treatment is 7-10 days.
• For children, the medicine is prescribed at a dose of 25 mg/kg body weight on the first day, and 12.5 mg/kg per day in subsequent days.
• The medication must be taken for another 2-3 days after the body temperature drops. While using the medicine, it is necessary to limit the patient's exposure to the sun or exposure to ultraviolet radiation.

It is necessary to strictly observe the time interval for taking the pills. Do not take a double dose if the drug was not taken on time. In this case, you should drink it as quickly as possible, and not move the dose too close to the next one to avoid an overdose.

In small animal veterinary medicine, pediatric dosages of the drug are used.

Side effect

The use of Sulfadimethoxine may cause the following side effects:

• Central nervous system: possible headache.
• Hematopoietic system: rarely – agranulocytosis, leukopenia.
• Digestive system: cholestatic hepatitis, nausea, dyspeptic symptoms, vomiting.
• Allergic manifestations: drug fever, skin rashes

Overdose

The state of oversaturation of the body with the drug is clinically manifested in intense thirst, severe dry mouth, small amounts of rich yellow-brown urine, pain in the right hypochondrium (liver projection) and lower back (renal localization). Biochemical analysis will reveal a significant increase in enzymes such as AST, ALT and acid phosphatase.

Therapeutic measures for overdose:

1. Reflexogenic initiation of vomiting.
2. Gastric lavage or high cleansing enema.
3. Oral astringents and adsorbents.
4. Saline laxatives.
5. Forced diuresis, if the drug has been completely absorbed from the gastrointestinal tract.

Special instructions

It is used externally as part of combination preparations.

Interaction with other drugs

Sulfadimethoxine reduces the effectiveness of bactericidal antibiotics that act only on dividing microorganisms (including penicillins, cephalosporins).

Gross formula

C11H12N4O3S

Pharmacological group of the substance Sulfamonomethoxin

Nosological classification (ICD-10)

CAS code

1220-83-3

Characteristics of the substance Sulfamonomethoxin

White or off-white crystalline powder. Very poorly soluble in cold water, poorly soluble in alcohol, easily soluble in dilute hydrochloric acid.

Pharmacology

Pharmacological action- antibacterial, bacteriostatic, antimicrobial.

It is an antagonist of para-aminobenzoic acid and competitively inhibits dihydropteroate synthetase, which ensures the synthesis of folates in the bacterial cell (folic and dihydrofolic acids). A decrease in the amount of dihydrofolic acid and its active metabolite, tetradihydrofolic acid, leads to disruption of the transfer of one-carbon fragments and stops the formation of purines, pyrimidines and DNA: the growth and reproduction of most gram-positive and gram-negative microorganisms, chlamydia, plasmodium, and toxoplasma stops.

After oral administration, it is quickly and completely absorbed into the gastrointestinal tract. Bioavailability is 70-100%. In the blood, it is 50-60% bound to plasma proteins. Penetrates well into various organs and tissues. Passes through the placental barrier and enters breast milk. It does not penetrate through the intact BBB. It undergoes biotransformation in the liver by acetylation with the formation of inactive metabolites. Excreted by the kidneys in the form of metabolites. Acid urine may promote stone formation.

Use of the substance Sulfamonomethoxine

Bronchitis, tracheitis, pharyngitis, laryngitis, otitis media.

Contraindications

Hypersensitivity, liver and kidney dysfunction, blood diseases, megaloblastic anemia, porphyria, glucose-6-phosphate dehydrogenase deficiency, pregnancy, breastfeeding (breastfeeding is stopped during treatment), children (up to 14 years).

Side effects of the substance Sulfamonomethoxine

Headache, dizziness, lethargy, dyspeptic symptoms (nausea, vomiting, diarrhea), interstitial nephritis, tubular necrosis, crystalluria, hematuria, liver damage, photosensitivity, thyroid dysfunction, hypocoagulation, agranulocytosis, leukopenia, methemoglobinemia, anemia, allergic reactions: Lyell's syndrome, Stevens-Johnson syndrome, urticaria, anaphylactic shock.

Name: Sulfamonomethoxinum

Pharmacological effects:
Long-acting sulfanilamide drug. Rapidly absorbed; penetrates the blood-brain barrier (barrier between blood and brain tissue). Relatively low toxic. In terms of the spectrum of antibacterial action and indications for use, it is close to sulfapyridazine.

Sulfamonomethoxine - indications for use:

Respiratory tract infections, purulent infections of the ear, throat, nose, dysentery, enterocolitis (inflammation of the small and large intestines), bile duct and urinary tract infections, pustular skin diseases, wound infection, generalized meningococcal infection (a disease caused by meningococcal bacteria), purulent meningitis ( purulent inflammation of the meninges), gonorrhea; to prevent purulent bacterial infection in the postoperative period.

Sulfamonomethoxine - method of application:

Before prescribing a medicine to a patient, it is advisable to determine the sensitivity of the microflora to it that caused the disease in this patient. Orally 0.5-1 g 2 times on the first day of treatment, then 0.5-1 g once a day; children - 25 mg/kg on the first day of treatment and 12.5 mg/kg on subsequent days. The course of treatment is 7-14 days.
For meningitis, on the first day, 2 g 2 times a day, then 2 g once a day. For gonorrhea, the first two days, 1.5 g 3 times a day and 1 g in subsequent days. The course of treatment is 5 days.

Sulfamonomethoxine - side effects:

In some cases, nausea, headache, leukopenia (decrease in the level of leukocytes in the blood), allergic reactions.

Sulfamonomethoxine - contraindications:

Allergic reactions to sulfonamides.

Sulfamonomethoxine - release form:

Tablets of 0.5 g in a package of 15 pieces.

Sulfamonomethoxine - storage conditions:

List B. In a place protected from light.

Sulfamonomethoxin - synonyms:

Daimeton, Dufadin.

Important!
Before using the medicine Sulfamonomethoxin you should consult your doctor. This instruction is intended for informational purposes only.

substance-powder: packages Reg. No.: 73/636/13

Clinical and pharmacological group:

Release form, composition and packaging

substance -powder.

double-layer paper bags.

Description of the active components of the drug " Sulfamonomethoxin»

Pharmacological action

Antibacterial agent, sulfanilamide derivative. Has a long lasting effect. Active against Streptococcus spp. (including Streptococcus pneumoniae, Enterococcus spp.), Staphylococcus spp., Escherichia coli, Shigella spp., some strains of Proteus spp., Neisseria gonorrhoeae, Neisseria meningitidis.

Sulfamonomethoxine is also active against Chlamydia spp., Toxoplasma gondii, Plasmodium.

Rapidly absorbed from the gastrointestinal tract, penetrates the BBB. Relatively low toxic.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to sulfamonomethoxine.

Dosage regimen

Take orally 1 time/day. Depending on the severity of the disease, adults on the 1st day of the disease - 1-2 g / day, on subsequent days - 500 mg-1 g / day. Children on the 1st day of illness - 25 mg/kg, on subsequent days - 12.5 mg/kg.

Side effect

Rarely: headache, dyspeptic symptoms, skin rashes, drug fever, leukopenia.

Contraindications

Hypersensitivity to sulfamonomethoxine.

Application for children

Application is possible according to the dosage regimen.

Special instructions

If adverse reactions develop, the dose should be reduced and, if necessary, discontinued. Can be used in combination with trimethoprim.

Synonyms:

Sulfamonomethoxin, Daimeton, Duphadin, Sulfamonomethoxinum, Sulfamonomethoxine.

Description

Active ingredient - Sulfamonomethoxin: 4 - (para-Aminobenzenesulfamido) - 6 - methoxypyrimidine, or 4-sulfamido - 6 - methoxypyrimidine.

Pharmacological action

Sulfamonomethoxine is a long-acting sulfonamide drug, an antimicrobial bacteriostatic agent. Active against gram-positive microorganisms: Streptococcus spp. (including Streptococcus pneumoniae), Enterococcus spp., Staphylococcus spp. and gram-negative bacteria: Escherichia coli, Shigella spp., some strains of Proteus spp., Neisseria gonorrhoeae, Neisseria meningitidis, active against Chlamydia trachomatis, Toxoplasma gondii, Plasmodium spp. The mechanism of action is due to competitive antagonism with PABA, inhibition of dihydropteroate synthetase, disruption of the synthesis of tetrahydrofolic acid, necessary for the synthesis of purines and pyrimidines.

Indications for use

Respiratory tract infections, purulent infections of the ear, throat, nose, dysentery, enterocolitis, biliary and urinary tract infections, pustular skin diseases, wound infection, generalized meningococcal infection, purulent meningitis, gonorrhea; for the prevention of purulent bacterial infection in the postoperative period.

Directions for use and doses

Sulfamonomethoxin is taken orally 0.5-1 g 2 times on the 1st day of treatment, then 0.5-1 g 1 time per day; children: 25 mg/kg on the 1st day of treatment and 12.5 mg/kg on subsequent days. The course of treatment is 7-14 days.

For meningitis, on the 1st day, 2 g 2 times a day, then 2 g 1 time a day. For gonorrhea, the first 2 days, 1.5 g 3 times a day and 1 g in subsequent days. The course of treatment is 5 days.

Side effect

In some cases, nausea, headache, leukopenia, allergic reactions.

Contraindications

Toxic-allergic reactions to sulfonamides.

Interaction

Increases the effects of anticoagulants, anticonvulsants and oral hypoglycemic drugs, methotrexate, phenylbutazone, as well as the risk of side effects when prescribing myelosuppressants, oral contraceptives, hemolytic and hepatotoxic drugs. Reduces the effectiveness of cyclosporine and bactericidal drugs.

Special instructions

Release form

Tablets of 0.5 g, 10 pieces in a package.

Storage

List B. In a place protected from light.

Brief description of the drug. Sulfamonomethoxine is used in the treatment of respiratory tract infections, purulent infections of the ear, throat, nose, dysentery, enterocolitis, biliary and urinary tract infections, pustular skin diseases, wound infections, generalized meningococcal infections, purulent meningitis, gonorrhea.