Vermox 100 instructions for use. How to take Vermox from worms: instructions and reviews of people. When high doses are used for a long time

Release form

Tablets

Compound

Active ingredient: Mebendazole. Active ingredient concentration (mg): 100 mg

Pharmacological effect

Broad-spectrum anthelmintic drug. It is most effective in enterobiasis and trichuriasis. It prevents the formation of cellular tubulin in helminths, thus disrupting the utilization of glucose, and inhibits the formation of ATP in their body.

Pharmacokinetics

After oral administration, Vermox is poorly absorbed. A small part of the active substance, entering the blood, is 90% bound to plasma proteins and metabolized in the liver.

Indications

Contraindications

Hypersensitivity, ulcerative colitis, Crohn's disease, liver failure, children's age (up to 2 years).

Precautionary measures

In the course of the entire treatment, it is necessary to keep the peripheral blood picture, kidney and liver functions under control. Do not take alcohol, laxatives and fatty foods. Given the feedback from patients, this drug is effective and safe, so it can be used for both adults and children, not only for therapeutic, but also for preventive purposes. Side effects are mainly observed with uncontrolled use of the drug, as well as in the presence of individual intolerance.

Use during pregnancy and lactation

During pregnancy, especially in the first trimester, Vermox should be used with extreme caution, comparing the potential risk of prescribing the drug with the expected therapeutic effect. During the period of use of the drug should stop breastfeeding.

Dosage and administration

With enterobiasis, adults and children are prescribed 100 mg (1 tab.) of the drug once. To prevent re-invasion, the drug is repeated after 2 and 4 weeks at the same dose. With ascariasis, ankylostomidosis, trichuriasis, mixed helminthiases, adults and children over 1 year old are prescribed 100 mg 2 times a day (morning and evening) for 3 days. With teniasis and strongyloidiasis, adults are recommended to take 200 mg 2 times a day for 3 days. Children are prescribed 100 mg 2 times a day also for 3 days.

Side effects

Dizziness, nausea, abdominal pain. When used in high doses for a long time: vomiting, diarrhea, headache, allergic reactions (skin rash, urticaria, angioedema), increased activity of hepatic transaminases, hypercreatininemia, leukopenia, anemia, eosinophilia, hair loss, hematuria, cylindruria. May have a negative effect on fetal development. Overdose. Symptoms: abdominal pain, nausea, vomiting, diarrhea. When used in high doses for a long time: reversible liver dysfunction, hepatitis, neutropenia. Treatment: it is necessary to remove the drug from the stomach by inducing vomiting or by doing a gastric lavage, taking activated charcoal.

Overdose

Symptoms: abdominal cramps, nausea, vomiting, diarrhea. Treatment: There is no specific antidote. It is recommended to wash the stomach with an aqueous solution of potassium permanganate at the rate of 20 mg/100 ml of water. You can use activated charcoal.

Interaction with other drugs

Co-administration with cimetidine may increase the effect of Vermox by inhibiting hepatic metabolism of mebendazole and increasing plasma concentrations

special instructions

With prolonged use of Vermox, it is necessary to monitor the picture of peripheral blood, liver and kidney function. In patients with diabetes, it is necessary to control the concentration of glucose in the blood. During the day after the intake, the use of ethanol, fatty foods is prohibited, do not prescribe a laxative. Be sure to periodically examine the smears of the anal area and feces after the end of treatment: therapy is considered effective in the absence of helminths or their eggs for 7 consecutive days. The drug contains lactose, so patients with rare hereditary lactose intolerance, lactase deficiency or malabsorption of glucose / galactose should not prescribe this drug. Influence on the ability to drive vehicles and control mechanisms. Patients should be careful when driving vehicles and working with machinery, since dizziness and drowsiness may occur during treatment.

Anthelminthic medicine is made in the form of white flat-cylindrical tablets with the designation Vermox on one side and a dividing line on the other. 1 tablet contains 100 mg of mebendazole, which is the active ingredient of the drug.

Additional ingredients: 3 mg magnesium stearate, 5 mg sodium saccharinate, 9 mg talc, 71 mg corn starch, 110 mg lactose monohydrate, 1.5 mg colloidal silicon dioxide, 0.5 mg sodium lauryl sulfate.

The tablets are placed in contour foil blisters of 6 pcs. The box contains 1 foil blister.

Pharmacological properties of Vermox 100

Pharmacodynamics

The anthelmintic agent is active against such pathogens:

Trichinella nelsoni;
Trichinella nativa and spiralis;
Echinococcus multilocularis;
Strongyloides stercoralis;
Ancylostoma duodenale;
Trichuris trichiura;
Enterobius vermicularis.

The active substance of the drug disrupts the metabolism of glycogen and glucose in the tissue fibers of helminths, inhibits the production of tubulin by their cellular structures and slows down the secretion of ATP.

Pharmacokinetics

Mebendazole is almost not absorbed in the esophagus. After oral administration of the drug at a dosage of 100 mg twice a day for 3 days, the plasma concentration of the active ingredient is 0.03-0.09 μg / ml of blood.

The half-life of the drug is 2.5 to 6 hours. Most of the dose taken from the body is excreted in its original form through the intestines. The part that is absorbed by the esophagus (from 5 to 10%) is excreted along with the urine.

Indications for use Vermox 100

An anthelmintic drug can be prescribed to patients with the following diseases:

taeniasis;
trichinosis;
strongyloidiasis;
hookworm;
ascariasis;
combined forms of helminthiasis;
echinococcosis;
enterobiasis.

Contraindications

Doctors prohibit the use of medicine in such cases:

in combination with Phenytoin, Metronidazole, Ritonavir and Carbamazepine;
with lactase deficiency and lactose intolerance;
during breastfeeding and during gestation;
patients under 3 years of age;
with severe liver failure;
with Crohn's disease;
with acute ulcerative colitis;
with hypersensitivity to mebendazole and other ingredients of the anthelmintic drug.

How to take Vermox 100

An anthelmintic medicine is taken orally and washed down with water.

Patients older than 3 years in the treatment of enterobiasis are prescribed doses of 100 mg per day. Combined helminthiases are treated with doses of 100 mg 2 times a day (morning and evening) for 3 days. If signs of pathology persist, it is advisable to repeat the therapeutic course after 3 weeks.

Patients over 14 years of age with echinococcosis in the first 3 days are prescribed doses of 500 mg twice a day. The average treatment time is 4 to 6 weeks. With trichinosis, the drug is prescribed in dosages of 200-300 mg three times - on the first day, from 200 to 300 mg four times - on the second day, 500 mg three times a day - from 3 to 14 days.

Side effects of Vermox 100

Allergic manifestations: angioedema, urticaria, toxic epidermal necrolysis, Stevens-Johnson syndrome, anaphylactoid and anaphylactic conditions.

The hematopoietic system may respond to the drug with the occurrence of neutropenia.

Reactions from the digestive tract: diarrhea, increased activity of transaminases in the liver, hepatitis, urge to vomit.

From the side of the central nervous system: convulsive conditions, fatigue, headaches, confusion.

From the urinary system: glomerulonephritis, hypercreatininemia.

Deviations of clinical indicators: eosinophilia, anemia and leukopenia.

Other: baldness.

Overdose

The condition may be accompanied by pain in the abdominal region, diarrhea, nausea and vomiting. In chronic overdose, irreversible liver damage, neutropenia and hepatitis may develop.

To help, the medication must first be removed from the stomach, provoking a gag reflex and clearing the intestines. Then you should drink a few tablets of activated charcoal or other sorbent.

special instructions

When taking a long course of taking an anthelmintic medication, patients require regular monitoring of blood composition, kidney and liver function.

In diabetics, when taking the drug, it is required to control the level of glucose in the blood.

After completion of treatment, you need to pass a fecal analysis and make a smear of the anal area. Treatment is effective if helminths and their larvae are absent within 1 week.

Patients need to be careful when taking the drug when operating complex equipment, as drowsiness and confusion may occur.

Use during pregnancy and lactation

An anthelmintic agent is contraindicated for pregnant and lactating women.

Application in childhood

Not intended for patients under the age of 18.

For impaired renal function

The manufacturer does not provide information regarding the administration of the drug by patients with renal pathologies. Against the background of long-term use of the drug, regular monitoring of the work of the body is required.

IN 1 tablet 100 mg mebendazole.

Sodium lauryl sulfate, magnesium stearate, silicon dioxide, sodium saccharinate, starch, lactose monohydrate, talc, as excipients.

In 5 ml suspensions 100 mg medendazole.

Release form

Suspension 2%.
Tablets 100 mg.

pharmachologic effect

Anthelmintic .

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Detrimental to eggs roundworm , hookworm . In large doses, it is used to treat and - extraintestinal helminthiases. The drug is well tolerated.

Pharmacokinetics

Almost not absorbed in the intestine. 90% binds to blood proteins. The half-life is from 2.5 to 5 hours. Accumulates in helminth larvae, liver and adipose tissue. Metabolized in the liver. About 5-10% of the drug is absorbed and then excreted by the kidneys. More than 90% is excreted in the feces.

Indications for use

strongyloidiasis ;
enterobiasis ;
trichuriasis ;
taeniasis ;
trichinosis ;
alveococcosis ;
echinococcosis ;
capillariasis ;
mixed helminthiases .

Contraindications

liver failure ;
ulcerative ;
hypersensitivity;
age up to 2 years;
Crohn's disease ;
pregnancy and breastfeeding.

Side effects

stomach ache;
dizziness;
nausea.

When using high doses for a long time:

vomiting, stool disorder;
headache;
rash, ;
hair loss;
level up creatinine ;
hematuria and cylindruria ;
increased activity of liver enzymes;
leukopenia , eosinophilia , anemia .

Vermox tablets, instructions for use (Method and dosage)

Tablets are taken orally. How to take Vermox: before or after food? Tablets are taken after meals.

Adults and children from 10 years of age with identified enterobiasis appoint once 100 mg. Children from 2 to 5 years old 25 mg once, from 5 to 10 years 50 mg once. All family members are being treated. With a high probability of reinvasion - again after 2 weeks at the same dosage.

At ascariasis , hookworm infection , teniose , trichuriasis , strongyloidiasis or mixed helminthiases take twice a day, 100 mg for 3 days in a row.

At trichinosis three times a day, 200-400 mg for 3 days in a row, from day 4, the dose is increased by 400-500 mg three times a day and taken until the 10th day.

Instructions for the use of Vermox contains a warning that the day after taking the pills you can not drink alcohol, fatty foods, take a laxative. After the end of treatment, it is necessary to examine smears and feces for the presence of helminths and their eggs within 7 days. With long-term treatment, it is necessary to monitor the function of the liver and kidneys, a blood test.

Overdose

Symptoms: abdominal pain, nausea, , vomit.

When treated with high doses, there are long-term hepatitis transient dysfunction of the liver, neutropenia .

Treatment begins with gastric lavage, taking sorbents , conducting symptomatic therapy if necessary.

Interaction

Mebendazole reduces the need for insulin at .

Avoid concurrent appointment lipophilic substances .

Terms of sale

On prescription.

Storage conditions

At a temperature not exceeding 30 C.

Best before date

Vermox for children

At enterobiasis (infection pinworms ) treatment is carried out for one day: from 2 to 5 years 1/4 tablet once, from 5 to 10 years 1/2 tablet, over 10 years 1 tablet. It is obligatory to take the drug again in the same dose after 2 weeks. It is also recommended to wash the laundry at a high temperature (90C) for all family members.

You need to know that the drug causes increased motor activity of helminths, sometimes this leads to antiperistalsis , vomiting and casting roundworm into the respiratory tract. Therefore, with intensive invasion in children, it should be used with caution.

Analogues

Coincidence in the ATX code of the 4th level:

Analogues , Vero-Mebendazole , mebex , , Telmox 100 .

Wormin or Vermox, which is better?

Wormil or Vermox, which is better?

Active substance albendazole . Highly effective drug for all helminthiases - possible treatment for enterobiasis and ascariasis before echinococcosis . This tool is used in pediatric practice. A convenient form of release - suspension of 400 mg and chewable tablets of 400 mg. According to doctors, the most effective drug. Manufacturer Milli Healthcare (England).

Vermox or Nemozol, which is better?

Vermox or Decaris, which is better?

has an active ingredient levamisole and its content in a tablet of 50 mg or 150 mg. Tablets with a lower dosage are intended for children, prescribed from 3 years. The drugs differ in their spectrum of action. This drug works only on round worms ( nematodes ): roundworm , necator , hookworm . If the analysis confirms the parasitism of nematodes, then the drug can be taken. Producer JSC Gedeon Richter, Hungary.

Composition and form of release

Tablets - 1 tab.:

Active substance: mebendazole - 100 mg;
Excipients: sodium lauryl sulfate - 0.5 mg, colloidal silicon dioxide - 1.5 mg, magnesium stearate - 3 mg, sodium saccharinate - 5 mg, talc - 9 mg, corn starch - 71 mg, lactose monohydrate - 110 mg.

6 pcs. - blisters, packs of cardboard.

Description of the dosage form

Tablets of white or almost white color, ploskotsilindrichesky, with a facet, with the inscription "VERMOX" on one party and risk - on another, with a slight characteristic smell.

pharmachologic effect

Broad-spectrum anthelmintic drug. Most effective against Enterobius vermicularis, Trichuris trichiura, Ascaris lumbricoides, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Taenia solium, Echinococcus granulosus, Echinococcus multilocularis, Trichinella spiralis, Trichinella nativa, Trichinella nelsoni.

Causing an irreversible violation of glucose utilization, it depletes glycogen stores in the tissues of helminths, prevents the synthesis of cellular tubulin, and also inhibits the synthesis of ATP.

Pharmacokinetics

Suction and distribution

Practically not absorbed in the intestine. After taking the drug at a dose of 100 mg 2 times / day for 3 consecutive days, the plasma concentration of mebendazole and its metabolite (2-amino derivative) does not exceed 0.03 μg / ml and 0.09 μg / ml, respectively.

Plasma protein binding - 90%. Unevenly distributed in organs, accumulates in adipose tissue, liver, helminth larvae.

Metabolism

In the liver, it is metabolized to a 2-amino derivative that does not have anthelmintic activity.

breeding

T1 / 2 is 2.5-5.5 hours. More than 90% of the dose is excreted through the intestines unchanged. The absorbed part (5-10%) is excreted by the kidneys.

Indications for use

enterobiasis;
ascariasis;
hookworm;
strongyloidiasis;
trichocephalosis;
taeniasis;
echinococcosis (if surgical treatment is impossible);
mixed helminthiases.

Contraindications for use

hypersensitivity to the drug;
severe liver disease.

Use in pregnancy and children

The use of the drug during pregnancy is contraindicated. There is no data on whether mebendazole is excreted in breast milk. If necessary, the use of the drug during lactation, it is recommended to stop breastfeeding. The drug is contraindicated in children under the age of 2 years.

Side effects

Allergic reactions: urticaria, angioedema, Stevens-Johnson syndrome, toxic epidermal necrolysis, exanthema, anaphylactic and anaphylactoid reactions.

From the hemopoietic system: neutropenia.

From the digestive system: nausea, vomiting, abdominal pain, diarrhea, increased activity of hepatic transaminases, alkaline phosphatase, hepatitis (when used in high doses for a long time).

From the nervous system: dizziness, headache, drowsiness, convulsions.

From the urinary system: hypercreatininemia, glomerulonephritis (when used in high doses for a long time).

Deviations in the results of laboratory tests: leukopenia, anemia, eosinophilia (when used in high doses for a long time).

Other: hair loss (when used in high doses for a long time).

drug interaction

Vermox reduces the need for insulin in diabetic patients. Co-administration with lipophilic substances should be avoided.

Cimetidine can increase the concentration of mebendazole in the blood, carbamazepine and other inducers of metabolism - lower, therefore, with these combinations, the concentration of drugs in the serum should be monitored.

Dosage

With enterobiasis, 100 mg once. Children aged 2 to 10 years - once 25-50 mg. In case of re-infection, the drug is repeated at the same dose after 2-4 weeks.

With ascariasis, ankylostomidosis, trichocephalosis and mixed invasions, 100 mg 2 times a day for 3 days.

For strongyloidiasis and teniasis, adults - 200 mg 2 times a day for 3 days, children - 100 mg 2 times a day for 3 days.

When trichinosis is prescribed 200-400 mg 3 times a day for 3 days, from 4 to 10 days - 400-500 mg 3 races per day.

tablets

Owner/Registrar

GEDEON RICHTER, Plc.

International Classification of Diseases (ICD-10)

B67 Echinococcosis B68 Teniasis B75 Trichinosis B76 Hookworm B77 Ascariasis B78 Strongyloidiasis B79 Trichuria B80 Enterobiasis B83.1 Gnathostomiasis B83.8 Other specified helminthiases

Pharmacological group

Anthelmintic drug

pharmachologic effect

Broad-spectrum anthelmintic drug. Most effective against Enterobius vermicularis, Trichuris trichiura, Ascaris lumbricoides, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Taenia solium, Echinococcus granulosus, Echinococcus multilocularis, Trichinella spiralis, Trichinella nativa, Trichinella nelsoni.

Causing an irreversible violation of glucose utilization, it depletes glycogen stores in helminth tissues, prevents the synthesis of cellular tubulin, and also inhibits the synthesis of ATP.

Pharmacokinetics

Suction and distribution

Plasma protein binding - 90%. Unevenly distributed in organs, accumulates in adipose tissue, liver, helminth larvae.

Metabolism

In the liver, it is metabolized to a 2-amino derivative that does not have anthelmintic activity.

breeding

T 1/2 is 2.5-5.5 hours. More than 90% of the dose is excreted through the intestines unchanged. The absorbed part (5-10%) is excreted by the kidneys.

Enterobiasis;

Ascariasis;

Ankylostomiasis;

Strongyloidiasis;

trichuriasis;

Trichinosis;

Echinococcosis (if surgical treatment is impossible);

Mixed helminthiases.

Hypersensitivity to the components of the drug;

Ulcerative colitis;

Crohn's disease;

Liver failure;

Children's age up to 3 years;

Pregnancy;

lactation period;

Lactose intolerance, lactase deficiency, glucose-galactose malabsorption;

Simultaneous reception with metronidazole, phenytoin, carbamazepine, ritonavir.

Allergic reactions: urticaria, angioedema, Stevens-Johnson syndrome, toxic epidermal necrolysis, exanthema, anaphylactic and anaphylactoid reactions.

From the hematopoietic system: neutropenia.

From the digestive system: nausea, vomiting, abdominal pain, diarrhea, increased activity of hepatic transaminases, alkaline phosphatase, hepatitis (when used in high doses for a long time).

From the nervous system: dizziness, headache, drowsiness, convulsions.

From the urinary system: hypercreatininemia, glomerulonephritis (when used in high doses for a long time).

Deviations in the results of laboratory tests: leukopenia, anemia, eosinophilia (when used in high doses for a long time).

Others: hair loss (when used in high doses for a long time).

Overdose

Symptoms: abdominal pain, nausea, vomiting, diarrhea. When used in high doses for a long time: reversible liver dysfunction, hepatitis, neutropenia.

Treatment: it is necessary to remove the drug from the stomach by inducing vomiting or by doing a gastric lavage, taking activated charcoal.

special instructions

With prolonged use of Vermox, it is necessary to monitor the picture of peripheral blood, liver and kidney function.

In patients with diabetes, it is necessary to control the concentration of glucose in the blood.

During the day after the intake, the use of ethanol, fatty foods is prohibited, do not prescribe a laxative.

Be sure to periodically examine the smears of the anal area and feces after the end of treatment: therapy is considered effective in the absence of helminths or their eggs for 7 consecutive days.

The drug contains lactose, so patients with rare hereditary lactose intolerance, lactase deficiency or malabsorption of glucose / galactose should not prescribe this drug.

Influence on the ability to drive vehicles and control mechanisms

Patients should be careful when driving vehicles and working with machinery, since dizziness and drowsiness may occur during treatment.

With kidney failure

Data on the use of Vermox in patients with impaired renal function are not available. With prolonged use, it is necessary to monitor kidney function.

In violation of the functions of the liver

The drug is contraindicated in liver failure. With prolonged use, it is necessary to monitor liver function.

Elderly

Data on the use of the drug in elderly patients are not provided.

Use during pregnancy and lactation

Vermox is contraindicated during pregnancy and during breastfeeding.

There is no data on whether mebendazole is excreted in breast milk. If necessary, the use of the drug during lactation, it is recommended to stop breastfeeding.

drug interaction

Vermox reduces the need for insulin in diabetic patients. Co-administration with lipophilic substances should be avoided.

Inside with a little water.

Adults and children over 3 years old at enterobiasis- 100 mg 1 time / day, with mixed helminthiases- morning and evening 100 mg for 3 days. If the symptoms of the disease persist, it is recommended to repeat the course of treatment after 3 weeks.

Adults and children over 14 years of age: at echinococcosis in the first 3 days - 500 mg 2 times / day, in the next 3 days the dose is increased to 500 mg 3 times / day; in the future, the dose is increased to 1000-1500 mg 3 times / day. The average duration of treatment for echinococcosis caused by Echinococcus granulosus is 4-6 weeks, caused by Echinococcus multilocularis - up to 2 years. At trichinosis- on the 1st day, 200-300 mg 3 times / day, on the 2nd day, 200-300 mg 4 times / day, and from 3 to 14 days - 500 mg 3 times / day.

It is recommended that all family members be treated simultaneously. At ascariasis, trichuriasis, ankylostomidosis, teniasis, strongyloidiasis and mixed helminthiases- morning and evening 100 mg for 3 days.

Storage conditions and shelf life

The drug should be stored out of the reach of children at a temperature of 15 ° to 30 ° C. Shelf life - 5 years. Do not use after the expiry date stated on the packaging.