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Marking of insulin syringes, calculation of insulin U-40 and U-100

First insulin drugs contained one unit of insulin per milliliter of solution. Over time, the concentration changed. Read in this article what an insulin syringe is and how to determine how much insulin is in 1 ml based on the labeling.

Types of insulin syringes

The insulin syringe has a structure that allows a diabetic to independently inject himself several times a day. The syringe needle is very short (12–16 mm), sharp and thin. The case is transparent and made of high quality plastic.

Syringe design:

• needle with protective cap
• cylindrical body with markings
• movable plunger to direct insulin into the needle

The body is long and thin, regardless of the manufacturer. This allows you to reduce the cost of divisions. For some types of syringes it is 0.5 units.

Insulin syringe - how many units of insulin are in 1 ml

To calculate insulin and its dosage, it is worth considering that in the bottles that are presented on pharmaceutical markets Russia and the CIS countries, contains 40 units per 1 milliliter.

The bottle is marked as U-40 (40 units/ml) . Regular insulin syringes used by diabetics are designed specifically for this insulin. Before use, it is necessary to make an appropriate calculation of insulin according to the principle: 0.5 ml of insulin - 20 units, 0.25 ml -10 units, 1 unit in a syringe with a volume of 40 divisions - 0.025 ml .

Each mark on an insulin syringe marks a certain volume; the graduation for insulin units is a graduation for the volume of the solution, and is designed for insulin U-40 (Concentration 40 units/ml) :

• 4 units of insulin - 0.1 ml of solution,
• 6 units of insulin - 0.15 ml of solution,
• 40 units of insulin - 1 ml of solution.

In many countries around the world, insulin is used, which contains 100 units in 1 ml of solution ( U-100). In this case, it is necessary to use special syringes.

Outwardly, they do not differ from U-40 syringes, however, the applied graduation is intended only for calculating insulin with a U-100 concentration. This kind of insulin 2.5 times higher than standard concentration (100 units/ml: 40 units/ml = 2.5).

How to use an incorrectly labeled insulin syringe

• The dosage established by the doctor remains the same and is determined by the body’s need for a specific volume of the hormone.
• But if a diabetic used U-40 insulin, receiving 40 units per day, then when treated with U-100 insulin, he will still need 40 units. These 40 units just need to be injected with a U-100 syringe.
• If you inject U-100 insulin with a U-40 syringe, the amount of insulin injected should be 2.5 times less .

For patients with diabetes mellitus when calculating insulin you need to remember the formula:

40 units U-40 is contained in 1 ml of solution and is equal to 40 units. insulin U-100 contained in 0.4 ml of solution

The insulin dosage remains unchanged, only the volume of insulin administered decreases. This difference is taken into account in syringes designed for U-100.

How to choose a quality insulin syringe

There are a lot of different names of syringe manufacturers in pharmacies. And since insulin injections become commonplace for a person with diabetes, it is important to choose high-quality syringes. Main selection criteria:

• indelible scale on the case
• built-in non-removable needles
• hypoallergenic
• silicone coating of the needle and triple laser sharpening
• small increment of divisions
• small needle thickness and length

Look at an example of an insulin injection. Learn more about insulin administration. And remember that a disposable syringe is only disposable, and reusing it is not only painful, but also dangerous.

Read also the article about. Perhaps if you have a big one overweight, such a pen will become a more convenient tool for your daily insulin injections.

Choose the right insulin syringe, carefully consider the dosage, and good health to you.

Today, the essence of the only course of treatment for diabetes mellitus (DM) is lifelong injections of a hormone that transports sugar into the body’s cells (insulin). For this reason, diabetics need to know what types there are. insulin syringe, and also to understand its volume, for example, how many ml are in u 40 and u 100 and what is the difference between them, only a few know.

It is worth noting that information about this is quite easy to find on the Internet and, if possible, you can go for a consultation with an endocrinologist. As for insulin itself, it has many names and you can look at the types of hormone in this photo:

The syringe is medical instrument for introducing liquid into the human body or removing biomaterial from it. It consists of a container, a piston that creates pressure and a needle. As for the types of insulin syringes, we can distinguish glass and plastic.

At the same time, a glass insertion tool is used quite rarely, because it requires constant processing and is quite difficult to make for insertion. In turn, the plastic version most often has a built-in needle and allows you to fully inject the drug without leaving residues inside the container.

A syringe made of plastic can be used more than once, but it is advisable to treat it with alcohol or other antiseptic solution before use.

As for the divisions on the insulin syringe, it will take a long time to get used to them, because not everyone can understand how many units of insulin there will be in 1-3 ml. To do this, you will have to study the formula for calculating volume.

Currently, in the post-Soviet space, bottles labeled U-40 (40 units/ml) and U-100 (100 units/ml) are used. The first type of insulin syringe can hold 40 units of insulin per 1 ml. The hormone is calculated as follows:

• 1 ml of hormone = 40 units;
• 0.5 ml of hormone = 20 units;
• 0.25 ml of hormone = 10 units.

It follows from this that 1 unit will be equal to 0.025 ml of the hormone. Thus, other indicators can be calculated, for example, 3 ml of the hormone will contain 120 units, respectively. In addition, for some people it is important not only how much insulin in milliliters is placed in an insulin syringe, but in milligrams and the following calculation can be used to calculate:

• 1 ml = 1000 mg;
• U-40 = 1 ml = 1000 mg
• U-100 = 2.5 ml = 2500 mg.

It is worth noting the features of calculating divisions on a U-40 syringe (graduation):

• 4 divisions = 0.1 ml;
• 20 divisions = 0.5 ml;
• 40 divisions = 1 ml.

Thus, according to the insulin division units drawn on the syringe, you can calculate how much solution is needed for injection. See insulin type U-40 syringe can be seen in this photo:

If the hormone is labeled U-100, then the calculation is carried out differently. In this case, 100 units. insulin is contained in 1 ml of solution, which means you will need special insulin syringes. Outwardly, U-100 is no different from U-40, but the drawn scale of divisions is useful only in the case of a certain concentration of the drug and the amount of hormone can be calculated using the following formula:

From this it turns out that insulin syringes made for diabetics labeled U-100 (100 units) contain 2.5 times more insulin than U-40, therefore, this must be taken into account when injecting. For convenience, you can remember this formula:

• U-40 = 1 ml = 40 units;
• U-100 = 0.4 = 40 units.

Sick people need to remember that the dose of the hormone prescribed by the doctor does not change, but only the volume of insulin administered becomes less. You can see such a syringe for insulin in this photo:

Drug recruitment process

Most experts advise purchasing syringes with a non-removable needle, since the pain will be felt significantly less during the injection process. In addition, there is no so-called “dead zone” where the medicine can enter, so the injection is carried out in full.

It is worth noting that due to current prices, not many people can afford to use syringes only once, especially for pensioners. For this reason, many patients with diabetes use it 2 or more times. Experts on this matter said that in general this can be done, but you need to follow all hygiene standards and put the syringe back in the box after the injection. At the same time, you need to remember that you should not use it more than 2 times, as the needle begins to become dull, and this will cause discomfort when injecting the drug.

Learning to use an insulin syringe is not difficult if you know all the intricacies of performing the injection, because it will depend on them final result. First you need to treat the lid of the bottle containing the insulin, and this must be done carefully, because shaking the contents is not always necessary. For medicine with short and quick action This is prohibited, but if it comes to a drug with a delayed effect, then it must be shaken well before use.

The set of the drug also has its own subtleties, because first you need to pull the piston to the desired division, and then pierce the stopper of the bottle and release air into it. Next, you need to turn it over and start collecting the hormone. There are situations when air gets inside the container through the needle, and to remove it it will be enough to tap the syringe a little and release a little of the drug. For this reason, doctors advise taking a little more medicine than needed.

Before the injection, the place where it will be placed needs to be treated with alcohol, but due to excessively dry skin in diabetics, it is better to use it for this purpose. warm water And detergent. As for the injection itself, it is performed at an angle of 45 or 75°, because the drug can enter the muscle instead of the subcutaneous tissue and there will be no effect.

After administering the hormone, the syringe must be held in place for 10-15 seconds, and only then the needle must be removed. This must be done so that the drug is well absorbed and the maximum effect is achieved.

You can see what actions are performed and how the injection is given in this video:

Syringe pen

Doctors are trying in every way to make the lives of people suffering from diabetes easier, and an insulin syringe pen, or as it is also called a pencil, is perfect for insulin injections and can simplify the injection procedure. Inside this device there is a special cartridge in which the drug is stored, which allows you to forget about carrying bags with syringes, bottles, etc. You can see the syringe pen in this photo:

The obvious advantages of a pen syringe include:

• Insulin dosage is more convenient, since the pen syringe has increments of 1 unit, while a simple syringe usually has increments of 2 units;
• Due to its volume, the sleeve does not need to be changed frequently;
• The insertion of the needle is usually not particularly felt;
• New varieties of syringe pens make it possible to use a variety of different types insulin;
• The needle in a pen syringe is always thinner than even the most expensive conventional syringe.

The injection can be given not only in the stomach, but also in any accessible place, which greatly simplifies the procedure. You can see how to use a syringe pen to inject insulin in this video:

Types of needles for syringes

So that the injection is not painful and does not accidentally get into muscle tissue It is necessary to carefully select the needle for injection. Doctors advise not to discomfort focus on the following dimensions:

• Length – 4-8 mm;
• Thickness - up to 0.33 mm.

Thus, than smaller size needles, the less painful the injection will be, especially if the injection is given to a child. You can see their real size in this photo:

Cost of syringes and consumables

As for how much an insulin syringe costs on average, you can see approximate prices below:

• Simple syringe 80 rub. 10 pcs.;
• Insulin syringe pen RUB 1,700-2,100;
• Needles for simple syringes 380-420 rub. 100 pcs.;
• Needles for syringe pens 43o-460 rub. 100 pcs.

Insulin administration is very important procedure for people with diabetes, so every diabetic should be able to choose the right insulin syringe for injection and know how it is performed.

Most accessible method administration of insulin to hormone-dependent diabetics is the use of special syringes. They are sold complete with short sharp needles. It is important to understand what a 1 ml insulin syringe means and how to calculate the dosage. Diabetic patients are forced to inject themselves. They must be able to determine how much hormone to administer based on the situation.

Composition of drugs

To calculate insulin in a syringe, you need to know what solution is used. Previously, manufacturers made medicines with a hormone content of 40 units. On their packaging you can find the U-40 marking. Now we have learned to make more concentrated insulin-containing liquids, which contain 100 units of the hormone per 1 ml. Such containers with solution are marked U-100.

In each U-100, the dose of the hormone will be 2.5 times higher than in U-40.

To understand how many ml are in an insulin syringe, you need to evaluate the marks on it. For injections, different devices are used, they also have U-40 or U-100 signs. The following formulas are used in the calculations.

1. U-40: 1 ml contains 40 units of insulin, which means 0.025 ml - 1 U.
2. U-100: 1 ml - 100 IU, it turns out, 0.1 ml - 10 IU, 0.2 ml - 20 IU.

It is convenient to distinguish instruments by the color of the cap on the needles: for a smaller volume it is red (U-40), for a larger volume it is orange.

The dosage of the hormone is selected by the doctor individually, taking into account the patient’s condition. But it is extremely important to apply necessary remedy for injection. If you draw a solution containing 40 units per milliliter into a U-100 syringe, using its scale as a guide, it will turn out that the diabetic will inject 2.5 times less insulin into the body than planned.

Markup features

You need to figure out how much of the drug is required. Injection devices with a capacity of 0.3 ml are available for sale, the most common being 1 ml. This precise size range is designed to ensure that people can inject a strictly defined amount of insulin.

The volume of the injector should be based on how many ml are indicated by one marking division. First, the total capacity should be divided by the number of large pointers. This will give you the volume of each of them. After this, you can count how many small divisions are in one large one, and calculate using a similar algorithm.

It is not the applied stripes that need to be taken into account, but the spaces between them!

Some models indicate the value of each division. A U-100 syringe can have 100 marks, broken up by a dozen large ones. It is convenient to count on them the right dosage. To administer 10 units, it is enough to draw the solution up to the number 10 on the syringe, which will correspond to 0.1 ml.

U-40s typically have a scale from 0 to 40, with each division representing 1 unit of insulin. To administer 10 units, you should also dial up the solution to the number 10. But here it will be 0.25 ml instead of 0.1.

The amount should be calculated separately if the so-called “insulin” is used. This is a syringe that holds not 1 cube of solution, but 2 ml.

Calculation for other markings

Usually, diabetics do not have time to go to pharmacies and carefully select the necessary equipment for injections. Missing the hormone administration date may cause sharp deterioration well-being, especially difficult cases there is a risk of falling into a coma. If a diabetic has a syringe on hand intended for administering a solution with a different concentration, he has to quickly recalculate.

If a patient requires a one-time injection of 20 units of a drug labeled U-40, and only U-100 syringes are available, then you should draw not 0.5 ml of solution, but 0.2 ml. If there is a graduation on the surface, then it is much easier to navigate by it! You need to choose the same 20 units.

How else are insulin syringes used?

ASD fraction 2 - this remedy is well known to most diabetics. It represents biogenic stimulant, which actively influences everything metabolic processes, passing through the body. The drug is available in drops and is prescribed to non-insulin-dependent diabetics with type 2 disease.

ASD fraction 2 helps reduce the concentration of sugar in the body and restore the functioning of the pancreas.

The dosage is set in drops, but why then a syringe if we are not talking about injections? The fact is that the liquid should not come into contact with air, otherwise oxidation will occur. To prevent this from happening, and also for accuracy of administration, syringes are used for the set.

Let's calculate how many drops ASD factions 2 in “insulin”: 1 division corresponds to 3 particles of liquid. This amount is usually prescribed when starting the drug and then gradually increased.

Features of various models

There are insulin syringes on sale that are equipped with removable needles and are of one-piece construction.

If the tip is soldered to the body, the medicine will be completely removed. With fixed needles, there is no so-called “dead zone” where part of the drug is lost. Achieve complete removal medication, if the needle is removed, is more difficult. The difference between the amount of hormone collected and injected can reach up to 7 units. Therefore, doctors advise diabetics to purchase syringes with non-removable needles.

Many people use the injection device several times. This is prohibited. But if there is no choice, then the needles mandatory are disinfected. This measure is extremely undesirable and is only permissible if the syringe is used by the same patient and it is impossible to use another one.

The needles on the “insulin”, regardless of the number of cubes in them, are shortened. The size is 8 or 12.7 mm. The release of smaller versions is impractical, since some insulin bottles are equipped with thick stoppers: the medicine may simply not be removed.

The thickness of the needles is determined by special markings: a number is indicated next to the letter G. You should focus on it when choosing. The thinner the needle, the less painful the injection will be. Given that insulin is administered several times daily, this is important.

What to pay attention to when performing injections

Each vial of insulin can be used multiple times. The remaining amount in the ampoule should be stored strictly in the refrigerator. Before administration, the drug is warmed to room temperature. To do this, remove the container from the cold and let it stand for about half an hour.

If you have to use a syringe multiple times, it must be sterilized after each injection to prevent infection.

If the needle is removable, then different models should be used to collect the medicine and administer it. Large ones are more convenient for taking insulin, while small and thin ones are better for injections.

If you need to measure 400 units of the hormone, you can take it into 10 syringes marked U-40 or 4 syringes labeled U-100.

When choosing a suitable injection device, you should focus on:

• The presence of an indelible scale on the case;
• Small step between divisions;
• Needle sharpness;
• Hypoallergenic materials.

You should take a little more insulin (1-2 units), since some amount may remain in the syringe itself. The hormone is taken subcutaneously: for this purpose, the needle is inserted at an angle of 75 0 or 45 0. This level of tilt allows you to avoid hitting the muscle.

When diagnosing insulin dependent diabetes The endocrinologist must explain to the patient how and when the hormone must be administered. If children become patients, the entire procedure is explained to their parents. For a child, it is especially important to correctly calculate the dose of the hormone and understand the rules for its administration, since a small amount of the drug is required, and an excess of it should not be allowed.

Currently, the cheapest and easiest way to administer insulin into the human body is to use a disposable syringe. Previously, less concentrated solutions of the drug were produced (1 ml included 40 units of the hormone), which is why it was possible to purchase a syringe to administer a concentration of 40 units/ml.

Today, 1 ml already contains 100 units of the hormone, and in order to introduce them into the human body, it is necessary to purchase a syringe for 100 units/ml. You can buy two types of insulin syringes at the pharmacy - 40 and 100 units/ml.

This is why patients with a history diabetes mellitus for whom the doctor recommended insulin injections certain dosage, you need to figure out how to calculate it correctly, and then enter the appropriate norm.

If you do not understand what the difference is, you can seriously harm your body and lead to severe and irreversible consequences due to the incorrect dosage of the drug.

Therefore, you need to find out what volume of syringe is needed in a given situation, and how many ml are in the insulin syringe?

To prevent patients from getting confused, the manufacturer applies a special graduation to the syringe, which indicates the concentration of insulin in the bottle of medicine. It is worth noting that each mark on the cylinder does not at all indicate milliliters of solution, it indicates the number of units.

Features of marking division:

• When a syringe is needed for U40 concentrate, on the marking line, where, as a rule, 0.5 ml is written, an indicator of 20 units is observed, and at the level of 1 ml, 40 units are written.
• With all this 1 insulin unit equals 0.025 ml of insulin.
• The U100 syringe has a parameter of 100 units, not 1 ml, and 50 units - 0.5 ml.

Diabetes mellitus requires the use of an insulin syringe of the required concentration. If the patient uses the hormone 40 units/ml, then U40 is required, and when the hormone is 100 units/ml, then U100.

Many patients wonder what will happen if they make a mistake and use the wrong syringe? For example, when U100 is filled with liquid with a concentration of 40 units/ml, instead of the required 20 units, only 8 will be obtained. That is, the dosage will be half as much as what is needed in this situation.

Another analogue can be given, when U40 and a solution of 100 units/ml are used, but in reality only 50 units will be obtained, but 20 are needed.

So that a diabetic can easily choose the required insulin syringe, manufacturers have come up with a specific identification mark to help select the required syringe:

1. The 40 units syringe has a red protective cap.
2. The 100 unit syringe has an orange cap.

In a similar way, you can distinguish insulin pens, which are designed for 100 units. In this regard, if for some reason the pen breaks down or is lost, it is important to know how much volume is in the syringe or insulin pen, and how to distinguish them.

In situations where the patient purchased the wrong product, an insulin overdose cannot be ruled out, which can lead to serious consequences, and even death.

How to choose a needle and determine the division price?

Patients are faced with the task of not only choosing the correct volume of the syringe, but also choosing a needle of the required length. The pharmacy sells two types of needles:

• Removable view.
• Non-removable view.

Medical experts advise choosing the second option, because removable needles have the ability to retain a certain amount medicinal substance, the volume of which can be up to 7 units.

Today, needles are produced whose length is 8 and 12.7 millimeters. They are not produced shorter than this length, because bottles of medicine with thick rubber stoppers are still sold.

In addition, the thickness of the needle is also important. The fact is that when insulin is injected with a thick needle, the patient will feel painful sensations. And using the thinnest possible needle, the injection is absolutely not felt by the diabetic. At the pharmacy you can buy syringes with different volumes:

1. 0.3 ml.
2. 0.5 ml.
3. 1 ml.

In the vast majority of cases, patients prefer to opt for 1 ml, which is marked with three types of markings:

• U 40.
• U 100.
• Scale in milliliters.

In some situations, you can purchase an insulin syringe that has a double designation. Before injecting yourself with medicine, you need to determine the entire volume of the syringe. To do this, you need to do the following:

1. First, the volume of the 1st division is calculated.
2. Next, the entire volume (indicated on the packaging) is divided by the number of divisions in the product.
3. Important: you need to count only intervals.
4. Then you need to determine the volume of one division: all small divisions are counted among all large ones.
5. Then, the volume of the large division is divided by the number of small divisions.

How is the insulin dose calculated?

It was found out how much the volume of the syringe is, and when to choose a syringe for U40 or U100, you need to find out how to calculate the dose of the hormone.

The hormonal solution is sold in packaging made according to medical standards, the dosage is indicated by means of BUA (biological units of action), which are designated “unit”.

Typically, a 5 ml vial contains 200 units of insulin. When you recalculate in a different way, it turns out that 1 ml of liquid contains 40 units of the drug.

Features of dosage administration:

• It is advisable to make the injection with a special syringe that has single divisions.
• If a standard syringe is used, then before administering the dose, you need to calculate the number of units included in each division.

The medicine bottle can be used many times. The medicine must be stored in a cold place, but not in the cold.

When using a hormone that has a prolonged effect, the bottle must be shaken before taking the medicine to obtain a homogeneous mixture. Before administration, the medicine must be warmed to room temperature.

To summarize, it is necessary to summarize that every diabetic should know what the syringe markings mean, which needle to choose correctly, and how to calculate the correct dosage. Only this knowledge will help you avoid negative consequences, and maintain the patient's health.