Pentalgin is a modern and very effective antispasmodic analgesic. It helps relieve pain of various origins, bring down the temperature during a cold and reduce the severity of inflammation.

Active ingredients and dosage form

The combined drug Pentalgin is produced in the form of tablets for oral administration. They contain non-steroidal anti-inflammatory components (and naproxen), a myotropic antispasmodic (drotaverine hydrochloride), a histamine and muscarinic receptor blocker (pheniramine maleate) as well as caffeine, which has psychostimulating and adaptogenic properties.

Light green tablets are supplied in blisters of 4, 6, 10 and 12 pieces.

Pentalgin: what do pills help with?

Pentalgin has analgesic, antispasmodic, anti-inflammatory and antipyretic properties.

Paracetamol blocks the enzyme cyclooxygenase in the central nervous system, and affects the centers of thermoregulation and pain, which determines its analgesic and antipyretic effect.

The NSAID naproxen reduces the activity of cyclooxygenase, thereby reducing the release of inflammatory mediators - prostaglandins.

Drotaverine helps relieve spasms of smooth muscle elements by suppressing the activity of the phosphodiesterase-4 enzyme.

Pheniramine has a mild sedative effect, reduces spasms and blocks specific histamine receptors. Under its influence, inflammatory exudation decreases.

Caffeine tones and dilates blood vessels and increases the bioavailability of other components.

A single dose for pain relief is 1 tablet, and the frequency of administration is 1-3 times a day.. Acceptable daily dose– 4 tablets. However, you should not use this drug for more than 5 days in a row. As an antipyretic (antipyretic) for colds, Pentalgin is taken for up to 3 days. If there is a need to continue treatment, you should consult your doctor.

Indications

Pentalgin is indicated for pain syndrome(including spastic origin) and increased temperature due to colds.

Contraindications

Pentalgin should not be taken by patients with the so-called. the “aspirin triad,” which includes salicylate intolerance and recurrent polyposis of the nose and nasal sinuses.

Other contraindications include:

• individual hypersensitivity to active or auxiliary ingredients of drugs;
• in organs digestive system;
• erosions and ulcers of the gastrointestinal tract (during exacerbation);
• inhibition of hematopoiesis;
• severe functional failure of the liver (including with and) and (or) kidneys;
• carried out;
• ventricular extrasystole;
• spicy ;
• high levels of potassium in the blood (hyperkalemia).

Pentalgin is not prescribed to children and adolescents under 18 years of age.

Pentalgin during pregnancy

For women during pregnancy and breastfeeding Pentalgin is contraindicated for children. The active components of the drug are able to bypass the hematoplacental barrier and are found in breast milk. If treatment is necessary during lactation, the question is raised about temporarily transferring the baby to artificial feeding or replacing the drug with a safer one.

Side effects

As a hypersensitivity reaction develops, skin rashes () may appear and swelling may develop.

Possible side effects of Pentalgin:

If at least one of the listed symptoms develops, treatment with the drug should be stopped and reported. side effects doctor.

Overdose

In case of an overdose, the liver can be seriously damaged (even hepatonecrosis, i.e., tissue death, cannot be ruled out). Signs appear 12-48 hours after taking a large dose of Pentalgin. Encephalopathy progresses against its background.

If the dose is significantly exceeded, the patient is impaired heart rate and kidney function, and the pancreas is affected.

Coma and death are possible.

In case of Pentalgin poisoning, you should call an ambulance, urgently perform a gastric lavage and give it to the victim.

An effective antidote for paracetamol is Acetylcysteine, but its use this drug makes sense only within 8 hours after poisoning.

If bleeding occurs in the gastrointestinal tract, the patient is advised to take antacids and additional gastric lavage with a cooled isotonic solution. For cupping epileptic seizures give an injection of Diazepam (iv). Overdose may cause depression respiratory function, therefore, additional oxygenation (the victim is given an oxygen cushion) and mechanical ventilation may be required. Intravenously administered saline solutions to normalize water and electrolyte balance.

Interaction with other medications

It is important to exclude the parallel use of Pentalgin with Rifampicin and drugs from the tricyclic and groups, since they increase the risk toxic damage liver. For the same reason, reception was excluded ethanol(incl. pharmaceutical tinctures alcohol based).

Paracetamol present in the combined drug potentiates the effect indirect anticoagulants , worsening blood clotting. Diflunisal increases the hepatotoxic effect of paracetamol by increasing its serum concentration by one and a half times.

Another active ingredient, naproxen, reduces the effectiveness of the diuretic. Furosemide and increases toxicity antibacterial agents from the group of sulfonamides. It also slows down the excretion of lithium.

The antispasmodic component drotaverine reduces the effectiveness of the remedy for – Levodopa.

Pheniramine has a depressant effect on the central nervous system in combination with sleeping pills And.

The biotransformation of caffeine in the body slows down when taken birth control pills,-fluoroquinolones Norfloxacin and Ciprofloxacin, as well as Medicines for treatment Disulfiram. Caffeine metabolism accelerates when taken in parallel anticonvulsants and antiepileptic drugs(in particular Primidone) and barbiturates.

Reception psychostimulants(including drinks containing caffeine) leads to excessive stimulation of the central nervous system(overexcitation and strengthening of reflexes or, conversely, inhibition).

You should not take Pentalgin and others at the same time non-steroidal anti-inflammatory drugs(especially those containing paracetamol).

Additionally

Particular caution should be observed when prescribing Pentalgin to persons with the following pathologies:

Patients suffering from these diseases are strongly recommended to consult with their doctor before starting treatment.

If symptomatic treatment lasts more than 5-7 days, monitoring of liver function indicators is required. A peripheral blood test (PBC) is also required.

Alcohol intake should be avoided during treatment!

Patients taking Pentalgin should be careful when administering vehicles. It is advisable to temporarily refuse to work with potentially dangerous mechanisms, since the ability to concentrate may be reduced.

Name:

Pentalgin

Pharmacological
action:

Pentalgin – combined analgesic, antipyretic and anti-inflammatory drug.
The drug contains 5 active ingredients, pharmacological properties which determine the pharmacological properties of the drug Pentalgin:

- paracetamol and metamizole sodium- non-selective non-steroidal anti-inflammatory drugs with pronounced antipyretic and analgesic effects; metamizole sodium also has a pronounced anti-inflammatory effect.
The mechanism of action of these substances based on their ability to inhibit prostaglandin synthesis by inhibiting the enzyme cyclooxygenase;

- phenobarbital– has pronounced antispasmodic, muscle relaxant and sedative activity, helps enhance the therapeutic effects of non-steroidal anti-inflammatory drugs;

- codeine – medicine groups narcotic analgesics, reduces the excitability of the cough center, has an analgesic effect.
In therapeutic doses does not cause oppression respiratory center and does not affect the secretory activity of the bronchi.
At frequent use codeine, as well as taking large doses possible development drug addiction.
Helps enhance action sedatives and non-steroidal anti-inflammatory drugs;

- caffeine– stimulates the central nervous system, prevents the development of collapse, strengthens therapeutic effects paracetamol and metamizole sodium.
After oral administration active ingredients The drug is well absorbed in the gastrointestinal tract.

Metamizole sodium biotransforms in the intestinal walls, the unchanged substance is not found in the bloodstream.
The degree of association of the active metabolite of metamizole with plasma proteins reaches 50-60%. Metabolized in the liver, is excreted primarily by the kidneys in the form of pharmacologically active and inactive metabolites.

Paracetamol has a high degree of binding to plasma proteins.
Paracetamol and caffeine are metabolized in the liver, are excreted primarily by the kidneys in the form of metabolites. The half-life of paracetamol ranges from 1 to 4 hours.

Phenobarbital is metabolized in the liver, is an inducer of microsomal liver enzymes. It is excreted primarily by the kidneys in the form of metabolites; the half-life is about 3-4 days.

Codeine penetrates well through the blood-brain barrier, accumulates in the body, predominantly accumulation of codeine is observed in adipose tissue, lungs, liver and kidneys. Hydrolysis of codeine is noted under the influence of tissue esterases, after which conjugation with glucuronic acid occurs in the liver.
Codeine metabolites have analgesic activity.
It is excreted mainly by the kidneys in the form of metabolites, some of it is excreted in bile.

Indications for
application:

Pain syndrome of various origins, including pain in joints, muscles, radiculitis, algodismenorrhea, neuralgia, toothache, headache(including those caused by cerebral vasospasm);
- pain syndrome associated with spasm of smooth muscles, incl. at chronic cholecystitis, cholelithiasis, postcholecystectomy syndrome, renal colic;
- post-traumatic and postoperative pain syndrome, incl. accompanied by inflammation;
- colds accompanied by febrile syndrome (as symptomatic therapy).

Directions for use:

Preparation taken orally, it is recommended to swallow the tablet whole, without chewing or crushing, with a drink required quantity water.
Should be observed interval of at least 4 hours between doses of the drug.
Duration of treatment and dose of the drug determined by the attending physician individually for each patient.

Adults and teenagers over 12 years of age:
- for acute short-term pain syndrome, 1 tablet of the drug is usually prescribed once;
- with prolonged pain syndrome, which is accompanied by various diseases musculoskeletal system and nervous system, usually prescribed 1 tablet of the drug 1-3 times a day.
The maximum duration of treatment is 5 days, unless the attending physician prescribes otherwise;
- as an antipyretic agent, 1 tablet of the drug is usually prescribed 1-3 times a day. The maximum duration of treatment is 3 days, unless the attending physician prescribes otherwise.

The maximum daily dose of the drug is 4 tablets.
At long-term use drug may develop drug dependence.

If it is necessary to use the drug for more than 7 days in a row, it is necessary to monitor liver function and the morphological composition of the blood.

Side effects:

Allergic reactions:
- skin rash, itching;
- urticaria, angioedema.
From the hematopoietic system:
- thrombocytopenia, leukopenia;
- agranulocytosis, anemia, methemoglobinemia.

From the side of the central nervous system:
- excitement, anxiety, increased reflexes;
- tremor, headache, sleep disturbances;
- dizziness, decreased concentration.

From the outside cardiovascular system : palpitations, arrhythmias, increased blood pressure.
From the digestive system:
- erosive and ulcerative lesions Gastrointestinal tract, nausea, vomiting;
- epigastric discomfort, abdominal pain, constipation;
- liver dysfunction.

From the urinary system: impaired renal function.
From the senses:
- hearing loss, tinnitus;
- increase intraocular pressure in patients with angle-closure glaucoma.
Others: dermatitis, tachypnea (increased breathing).

If any of the side effects indicated in the instructions get worse, or the patient notices any other side effects not listed in the instructions, he should inform the doctor.

Contraindications:

Erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase);
- gastrointestinal bleeding;
- complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including a history);
- severe liver failure;
- severe renal failure;
- inhibition of bone marrow hematopoiesis;
- condition after coronary artery bypass surgery;
- severe organic diseases of the cardiovascular system (including acute myocardial infarction);
- paroxysmal tachycardia;
- frequent ventricular extrasystole;
- severe arterial hypertension;
- hyperkalemia;
- pregnancy;
- lactation period (breastfeeding);
- children and adolescents up to 18 years of age;
- hypersensitivity to the components of the drug.

Should be used with caution drug in patients with:
- cerebrovascular diseases, diabetes mellitus;
- diseases of peripheral arteries;
- history of ulcerative lesions of the gastrointestinal tract;
- with renal and liver failure of mild or moderate severity;
- viral hepatitis, alcoholic liver damage;
- benign hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes);
- epilepsy, with a tendency to seizures;
- deficiency of glucose-6-phosphate dehydrogenase;
- in elderly patients.
If you have any of the listed diseases and conditions the patient must consult a doctor before using the drug.

The use of the drug is contraindicated:
- during pregnancy and lactation (breastfeeding);
- in case of severe liver failure;
- in case of severe renal failure.
- children and adolescents up to 18 years of age.

WITHshould be avoided simultaneous use of the drug Pentalgin with other drugs containing paracetamol and/or NSAIDs, as well as with drugs to relieve symptoms of colds, flu and nasal congestion.

When using drug Pentalgin more than 5-7 days peripheral blood parameters and the functional state of the liver should be monitored.
Paracetamol distorts the results of laboratory tests of glucose and uric acid in blood plasma.
If it is necessary to determine 17-ketosteroids, Pentalgin® should be discontinued 48 hours before the study. Please note that naproxen increases bleeding time.

Effect of caffeine on central nervous system C depends on the type of nervous system and can manifest itself as both excitation and inhibition of higher nervous activity.
During the treatment period, the patient must avoid drinking alcohol.

In some cases Possible decreased concentration and speed of psychomotor reactions, therefore during the treatment period the patient should use caution when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Interaction with
other medicinal
by other means:

When taking the drug Pentalgin simultaneously with barbiturates, tricyclic antidepressants, rifampicin, ethanol the risk of hepatotoxicity increases(these combinations should be avoided).

Paracetamol enhances the effect indirect anticoagulants and reduces the effectiveness of uricosuric drugs.
Long-term use of barbiturates reduces the effectiveness of paracetamol.
When used simultaneously with paracetamol and ethanol, it increases risk of acute pancreatitis.
Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxic action of paracetamol.

Diflunisal increases plasma concentrations of paracetamol by 50%, which increases the risk of hepatotoxicity.

Naproxen is capable cause a decrease in the diuretic effect of furosemide, an increase in the effect of indirect anticoagulants, increases the toxicity of sulfonamides and methotrexate, reduces the excretion of lithium and increases its concentration in the blood plasma.

With the combined use of caffeine and barbiturates, primidone, anticonvulsants (hydantoin derivatives, especially phenytoin) Possible increased metabolism and increased caffeine clearance.
When taking caffeine and cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin simultaneously - decreased metabolism caffeine in the liver (slowing its excretion and increasing its concentration in the blood).

Concomitant use of caffeine-containing drinks and other drugs that stimulate the central nervous system, may lead to excessive stimulation of the central nervous system.

When used concomitantly, drotaverine may weaken the antiparkinsonian effect of levodopa.
With simultaneous use of pheniramine with tranquilizers, hypnotics, MAO inhibitors, ethanol possible increased depressant effect on the central nervous system.

Pregnancy:

Preparation contraindicated for use during pregnancy.
If it is necessary to use the drug during lactation, the issue of interrupting breastfeeding should be resolved.

Overdose:

Symptoms:
- pale skin, anorexia (lack of appetite);
- abdominal pain, nausea, vomiting, gastrointestinal bleeding;
- agitation, motor restlessness, confusion;
- tachycardia, arrhythmia, hyperthermia (increased body temperature);
- frequent urination, headache, tremors or muscle twitching;
-epileptic seizures, increased activity of liver transaminases;
- hepatonecrosis, increased prothrombin time.

Symptoms of liver dysfunction may appear 12-48 hours after an overdose.
In case of severe overdose liver failure develops with progressive encephalopathy, coma, death; acute renal failure with tubular necrosis; arrhythmia, pancreatitis.
If you suspect an overdose, you should immediately seek medical help..

Treatment: gastric lavage followed by activated charcoal.
The specific antidote for paracetamol poisoning is acetylcysteine.
The administration of acetylcysteine ​​is important within 8 hours after taking paracetamol.

For gastrointestinal bleeding it is necessary to administer antacids and gastric lavage with an ice-cold 0.9% sodium chloride solution; maintaining pulmonary ventilation and oxygenation; for epileptic seizures - intravenous administration of diazepam; maintaining fluid and salt balance.

Release form:

Pentalgin tablets, film-coated in 2, 4, 6, 10, 12, 20 or 24 pcs.
Pills Pentalgin-IC
Pills Pentalgin-ICN 12 pieces in a blister, 1 blister in a cardboard box.
Pills Pentalgin-FS 10 pieces in a blister, 1 blister in a cardboard box.
Pills Pentalgin FS Extra in a blister pack 10 pcs., in a cardboard pack 1 or 2 packs or 12 pcs., in a cardboard pack 1 pack.
Pills Pentalgin-N 10 pcs in a blister pack, 1 or 2 packs in a box.

Storage conditions:

It is recommended to store the drug in a dry place, protected from direct sunlight, at a temperature not exceeding 25 degrees Celsius.
Best before date regardless of the form of release – 3 years.
The drug is approved for use as over-the-counter products.

1 tablet of the drug Pentalgin-IC contains:
- metamizole sodium – 300 mg;
- paracetamol – 200 mg;
- caffeine – 20 mg;
- phenobarbital – 10 mg;
- codeine phosphate – 9.5 mg (in terms of codeine – 7 mg);
Excipients: potato starch, calcium stearate, food gelatin.

1 tablet of the drugPentalgin-ICN contains:
- metamizole sodium – 300 mg;
- paracetamol – 300 mg;
- caffeine – 50 mg;
- phenobarbital – 10 mg;
- codeine phosphate – 8 mg.
Excipients: potato starch, povidone (low molecular weight medical polyvinylpyrrolidone), stearic acid, calcium stearate.

1 tablet of the drug Pentalgin-FS contains:
- metamizole sodium – 300 mg;
- paracetamol – 300 mg;
- caffeine – 50 mg;
- phenobarbital – 10 mg;
- codeine phosphate – 8 mg.
Excipients: potato starch, polyvinylpyrrolidone, stearic acid, calcium stearate.

1 tablet Pentalgin FS Extra contains:
- metamizole sodium and paracetamol 0.3 g each;
- caffeine - 0.05 g;
- codeine phosphate - 0.008 g;
- phenobarbital - 0.01 g.
Excipients: starch, talc, calcium stearate.

1 tablet Pentalgin-N contains:
-naproxen - 100 mg;
- metamizole sodium - 300 mg;
- codeine - 8 mg;
- caffeine - 50 mg;
- phenobarbital - 10 mg.
Excipients: potato starch, low molecular weight polyvinylpyrrolidone (povidone), sodium citrate, magnesium stearate.

Pentalgin is a widely used drug that is found in almost everyone's medicine cabinet. It is an analgesic with analgesic, anti-inflammatory and antispasmodic effects. It is so popular due to its availability, speed and complex effect on the human body. The presence of a number of active substances in the composition has made it effective in treating such common problems as fever, pain of any etiology, and spasms. Its use helps not only to relieve discomfort, but also such unpleasant consequences as swelling and inflammation.

New Pentalgin does not contain codeine and is available without a prescription.

Pentalgin: instructions for use

Consult your doctor! Usually the drug is taken orally, one tablet 1-3 times a day. The maximum dose per day is four tablets. Treatment is allowed for no more than three days to eliminate fever, and no longer than five days for pain. The exact dosage must be prescribed by a doctor.

The effectiveness of the drug lies in its unique composition, which incorporates the following components that have proven themselves in the treatment of common ailments: paracetamol, naproxen, phenobrabital, caffeine, drotaverine, pheniramine. Thanks to such a rich composition, taking Pentalgin helps to overcome pain of any nature and varying intensity:

• for radiculitis, neuralgia;
• toothache;
• spasms of smooth muscles (renal colic, cholecystitis, etc.);
• colds and infections accompanied by fever;
• pain resulting from injuries and surgery.

Can children and adolescents take Pentalgin?

The drugs Pentalgin-N, Pentalgin Plus and Pentalgin-ICN are approved for use in adults and children over 12 years of age, Pentalgin is approved for use only in adults (over 18 years of age), because There have been no studies of the effectiveness and safety of the drug in childhood and adolescence.

Contraindications for taking Pentalgin

• The medicine should not be taken by persons who are sick:
• ulcerative lesions of the digestive system, internal bleeding;
• pathologies of the heart and vascular system;
• bronchial asthma;
• arterial hypertension;
• having an allergy to the components present in the composition.

Is it possible for children to have Pentalgin photo

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Pentalgin tablets - instructions for use, composition

Pentalgin is a combination drug that has effective anti-inflammatory and analgesic effects. The therapeutic effect of the drug is due to the five main active components included in its composition. Instructions for use of Pentalgin tablets describe in detail its pharmacological properties and effects on the body. According to it, the drug has the ability to inhibit the synthesis of prostaglandins by blocking an enzyme such as cyclooxygenase in the central nervous system.

Pentalgin is a highly effective remedy for eliminating severe pain of various etiological origins. This non-steroidal and non-narcotic drug is able to cope with severe pain, as well as have a high anti-inflammatory and antipyretic effect. That is, this drug very quickly eliminates pain, various spasms, lowers the temperature and eliminates the source of inflammation.

The medicine has analgesic, antispasmodic, psychostimulating properties and effectively blocks H1-histamine receptors. The effect of the drug is provided by the following medicinal substances included in the composition:

Effectively eliminates spasms of any nature, has a beneficial effect on smooth muscles, biliary tract, genitourinary and vascular systems. The substance has a pronounced antispasmodic myotropic effect.

It is a non-narcotic analgesic that effectively reduces fever and eliminates pain. Its analgesic and antipyretic effect is due to the blockade of certain enzymes of the central nervous system, which leads to an effective effect on pain centers and regulates body temperature.

1. Naproxen.

An anti-inflammatory non-steroidal component that quickly eliminates the inflammatory process, has an analgesic effect and can also reduce fever. The action of the substance is associated with the suppression of the enzyme cyclooxygenase, which regulates the synthesis of prostaglandins. Naproxen actively prevents the development of inflammation and pain.

Dilates the blood vessels of tissues and muscles, has a beneficial effect on the kidneys and heart, eliminates fatigue, drowsiness, and increases physical and mental performance. Caffeine enhances the bioavailability and effect of analgesics that are included in Pentalgin. It increases the permeability of barriers and helps increase the therapeutic effect of the drug. Caffeine has a tonic effect on the blood vessels of the brain.

It is a histamine receptor blocker. Effectively relieves spasms and pain of various types, enhances the analgesic effect of paracetamol and naproxen.

Indications

What does Pentalgin help with? The product has a very wide range of applications. The drug is effective for headaches, rheumatic pain, and pain after surgery. Main indications for use of the drug:

These drugs are also often prescribed:

• for complex therapy of ARVI and influenza;
• at high temperature;
• during the inflammatory process;
• for muscle pain;
• fever;
• pain after injury;
• pain after surgery;
• pain due to cholelithiasis;
• for chronic cholecystitis;
• renal colic.

The medicine is in the form of tablets. The maximum permissible dose of the drug is 4 tablets per day. It is important to know that long-term use of Pentalgin tablets can cause drug dependence. It is not recommended to use the drug in treatment for more than seven days. In case of such a need, it is necessary to monitor the functioning of the liver and kidneys, as well as the composition of the blood.

Contraindications

Pentalgin should not be used while pregnant or breastfeeding. Also, the drug is not used in the treatment of children under 12 years of age. Main contraindications:

• tachycardia;
• myocardial infarction;
• renal failure;
• disturbances in liver function;
• nasal polyposis;
• bronchial asthma;
• intestinal bleeding;
• individual intolerance.

Pentalgin should be taken with caution by elderly people, people with diabetes, and people with epilepsy.

Types of the drug

Pentalgin N

The drug Pentalgin N includes metamizole sodium, phenobarbital, codeine, naproxen and caffeine. The medicine is available in tablets, in blister packaging (10 pieces). Phenobarbital provides a sedative effect and calms the nervous system. Codeine blocks certain receptors and effectively relieves pain. The drug is a non-narcotic analgesic. It has an analgesic effect and effectively copes with pain in various diseases.

Pentalgin N is used to eliminate any pain and during feverish conditions. It is used after operations, for colds, neuralgia, myalgia, radiculitis and other diseases. The drug very effectively relieves toothache, muscle pain and quickly eliminates migraines.

The medication is contraindicated in:

Pentalgin icn

There is also such a medicinal variety as the drug Pentalgin icn. This medicine contains paracetamol, caffeine, phenobarbital, codeine phosphate, metamizole sodium. It is a combined medication that has anti-inflammatory, analgesic and antipyretic effects. The drug effectively blocks pain by acting on inflammation centers. Reduces peristalsis of intestinal sphincters, relaxes smooth muscles, eliminates spasms.

The medicine is indicated for the elimination of pain of any etiology; it is used for headaches, colds, rheumatism, and after surgery. The product also perfectly eliminates toothache and muscle pain. The drug should not be used for a long time and uncontrolled.

Contraindications:

Side effect

The drug is very well tolerated by the body and rarely causes side effects. When taking the drug, in rare cases, the following manifestations may occur:

• nausea;
• vomit;
• stomach ache;
• sleep disturbance;
• anemia;
• visual impairment;
• heart rhythm failure;
• noise in the ears;
• increased intracranial pressure;
• stool disorders;
• allergic reaction.

Pentalgin for pain: recommendations for use

1. Pentalgin should not be used together with other non-narcotic analgesics, with Aminophenazone, since the combined use of these drugs causes increased toxicity in the body. Paracetamol, which is part of the drug, enhances the effect of anticoagulants and reduces the effect of enzyme agents.
2. Treatment with Pentalgin during alcohol intoxication is prohibited, since codeine, which is part of the drug, enhances the depressant effect of alcohol on the central nervous system.
3. Pentalgin enhances the effect of drugs such as Griseofulvin, Phenothiazine, Doxycycline, as well as estrogens and antidepressants. The effects of tranquilizers and sedatives enhance the analgesic effect of Pentalgin.
4. The use of the drug in large doses and its long-term use causes drug dependence. The drug must be taken one tablet 1-3 times a day. The tablet is swallowed whole and washed down with plenty of drinking water. Many patients are interested in how long it takes for Pentalgin to work? All active components of the drug are quickly absorbed into the stomach tissue and enter the bloodstream, after which they begin their effect in the body. The therapeutic and analgesic effects can be felt within 10-15 minutes after consuming one tablet of the drug.
5. Taking the drug does not depend on food intake. The maximum dose (single dose) may be two tablets in special cases. The duration of treatment is usually prescribed for 5-7 days. In case of urgent need, taking the drug can be continued under the supervision of the attending physician and regular monitoring of blood counts. Pentalgin should not be used in the treatment of children under 12 years of age.

Overdose

In case of an overdose of the drug, vomiting, nausea, weakness, decreased pulse and blood pressure may occur. Also, in case of overdose, an allergic reaction and depression of the central nervous system occur.

Use during pregnancy and lactation

Carrying a fetus requires a pregnant woman to pay special attention to her health. Any medication taken can cause a risk of developing various pathologies and developmental disorders in the unborn child. A pregnant woman needs to be as careful as possible when treating with medications. Any desire to take medications must be agreed with a gynecologist who knows the specifics of the course of pregnancy.

The drug Pentalgin and its varieties Pentalgin N, Pentalgin icn cannot be used during pregnancy! The instructions for the drug from the manufacturers of the drug prohibit its use during pregnancy at any stage of pregnancy. It is better for the expectant mother to use other, less dangerous drugs to relieve pain and treat her. Today, the pharmaceutical market offers pregnant women a large selection of various safe homeopathic remedies that are allowed to be used during pregnancy.

Pentalgin is also not used while breastfeeding. The active substances that make up the medicine are very quickly absorbed into the blood and pass into breast milk. For treatment with Pentalgin, it is better to transfer the child to artificial feeding or stop taking this medication.

Pentalgin for children

The drug can be taken after 12 years of age. Before this age, Pentalgin cannot be used in the treatment of children according to the instructions of the manufacturer of the drug. For children over 12 years of age, it is not advisable to use a single dose in the form of two tablets. Otherwise, the drug will have an extremely negative effect on the child’s body. You should also limit treatment to two to three tablets per day. The instructions allow children to be given 1 tablet of Pentalgin three times a day.

If weakness, nausea, allergies, vomiting, dizziness, tinnitus and other negative side effects occur, you should stop taking the drug and consult a doctor.

After surgery

The drug is a very strong pain reliever, so it is often used to eliminate various pains after surgical interventions. The drug can also be used effectively after tooth extraction. It is not advisable to take two tablets at a time. The components of the drug are designed to act quickly, so you should wait until the pain subsides.

This drug is widely used during the recovery period after major operations. You should know that a prescription for Pentalgin without codeine is not required to purchase the drug at a pharmacy. If the type of drug does not contain codeine, the medicine can be easily purchased at pharmacies.

The high effectiveness of Pentalgin in eliminating pain after surgery is due to the active properties of the drug components. In the body, paracetamol binds to plasma proteins and persistently blocks the development of prostaglandins. The medicinal substances of the drug act directly on the receptors that cause pain.

Phenobarbital, which is part of the product, has a relaxing effect on the nervous system, calms nerve receptors and reduces excitability. The complex effect of all components of Pentalgin allows you to quickly and permanently eliminate stabbing, cutting, pulling pain after surgery.

Analogues

Today, the pharmaceutical market offers a wide variety of painkillers. Pentalgin has its advantages over other painkillers, but sometimes it becomes necessary to replace it with similar drugs. There are cheaper analogues of Pentalgin, which have a similar composition and effect. When selecting a drug from a group of analogues, it is important to consult with your doctor in advance. Perhaps, due to the characteristics of the body, a similar drug will not be suitable.

The main analogues of Pentalgin:

Price

In retail pharmacies, the price of the drug may vary. Approximate cost:

• Pentalgin (12 pcs.) – 85-104 rubles;
• Pentalgin (24 pcs.) – 160 -170 rubles;
• Pentalgin icn (12 pcs.) – 50 rubles;
• Pentalgin N with drotaverine – 56 -106 rubles;
• Pentalgin N – 170 rubles.

Average price of analogues:

• Pentamialgin – 130 rubles;
• Pentalfen – 70 – 100 rubles;
• Sedal M – 120 – 230 rubles;
• Plivalgin – 50 rubles;
• Sedalgin plus – 126 – 260 rubles.

Reviews about the application

Review #1

I recently took Pentalgin after pancreatic surgery. The medicine is very effective and quickly relieves pain. Pentalgin is used by my whole family to relieve headaches and when teeth become inflamed. Good and high quality product.

Irina, 45 years old - Moscow

Review #2

I have known this medicine for a long time - it quickly eliminates any pain and makes you feel better within ten minutes after taking it. Sometimes I drink it when I have a sprain after a workout.

Konstantin, 33 years old - Novosibirsk

Review #3

I often use Pentalgin for headaches. Quickly relieves severe migraines. I recommend it as a good and high-quality pain reliever.

Nikita, 62 years old - Samara

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Pentalgin: what it helps with, instructions for use, price, reviews, analogues

Pentalgin is a combined medicinal product that has anti-inflammatory, analgesic, antispasmodic, and antipyretic effects. Such a wide range is explained by the fact that the composition includes several active ingredients at once. The instructions for use will tell you in detail what Pentalgin helps with and how to use it correctly.

Instructions for use

In accordance with the description, the product is available in tablets; the duration of action of the drug on the body is from four to six hours.

Composition, action

The drug contains five components: paracetamol, metamizole sodium, phenobarbital, codeine, caffeine. Paracetamol and metamizole sodium have an analgesic effect and exhibit an anti-inflammatory effect. Phenobarbital enhances the therapeutic effect of non-steroidal anti-inflammatory drugs. Codeine reduces arousal and has a characteristic analgesic effect. Caffeine dilates blood vessels in the brain, increases productivity, relieves lethargy, and improves well-being.

Pentalgin N contains naproxen instead of paracetamol.

Indications

Pentalgin will help with muscle and joint pain.

The indications for use of the drug note that this remedy helps with:

• joint pain;
• muscles;
• sciatica;
• neuralgia;
• headache, toothache;
• migraine attacks;
• pain syndrome after injuries, surgical operations;
• during menstruation.

The medicine is also used for colds, to reduce high body temperature, inflammatory manifestations, and muscle pain.

Contraindications

Pentalgin is contraindicated in the following conditions:

• exacerbation of peptic ulcer of the stomach and duodenum;
• liver disease, kidney disease, heart disease;
• disorders of the circulatory system;
• hypersensitivity to the components of the drug.

The medicine should not be taken by patients with high blood pressure who have suffered head injuries. The drug is prescribed with caution to patients suffering from exacerbation of liver disease, kidney disease, diabetes, asthma, alcohol dependence, and patients with glaucoma.

Important! The use of the medicine by elderly patients is possible after consultation with a medical professional and only as prescribed.

Doses and rules of administration

Pentalgin should be taken without exceeding the prescribed dose.

Pentalgin tablet includes 325 mg of paracetamol, 100 mg of naproxen, 50 mg of caffeine, 40 mg of drotaverine, 10 mg of pheniramine maleate. The tablets are swallowed whole, do not bite or crush, and are washed down with water. The time interval between doses should be at least four hours.

The duration of taking the medicine and the dose are prescribed by the doctor to the patient personally. You are allowed to take no more than four tablets per day. Adult patients and children over 12 years of age are recommended to take one tablet 1 to 3 times a day.

When using this drug as an antipyretic, the duration of use is no more than three days, as an analgesic - five days; if there is a need to increase the duration of taking the medicine, you should consult with your doctor.

Important! Taking Pentalgin should not be combined with alcohol; you should refrain from work that requires increased attention and instant response to the situation. If side effects occur, it is advisable to stop taking the pills and contact your doctor for advice.

Overdose

In case of drug overdose the following is observed:

• nausea;
• vomit;
• lack of appetite;
• pain in the intestines;
• stomach bleeding;
• pale skin;
• rapid heartbeat;
• clouding of mind;
• elevated temperature;
• possible headache;
• convulsions;
• frequent urination;
• hysterical attacks;
• epilepsy.

Liver dysfunction may appear between 12 and 48 hours after an overdose. In case of severe poisoning of the body with the drug, the development of liver failure, coma, and possible death are possible. If an overdose occurs, you need to rinse your stomach, take activated carbon tablets, and be sure to contact a medical facility for medical assistance.

Side effects

The product may cause negative reactions in the body.

When using Pentalgin, patients experienced side effects of the drug. Indicators of side effects of the drug on the body are:

• disorders of the gastrointestinal tract;
• nervous, immune, respiratory systems;
• sense organs;
• allergy.

Pentalgin during pregnancy

Women should not take this medication during pregnancy. If the mother takes the drug while breastfeeding, the baby is transferred to formula milk.

Analogues

Analogues are Pentalfen, Pentamialgin (contain narcotic substances, sold by prescription in pharmacies), Plivalgin, Sedal M, Sedalgin plus, Santotitralgin, Citramon, Spazmalgon, Novigan. Cheap analogues are Andipal, Spazgan, Caffetin, Ibuprofen, Drotaverine, Paracetamol, they help with moderate pain. If Pentalgin is changed to another medicine, it is necessary to consult a doctor, only he will be able to suggest similar substitutes for the drug.

Price

In pharmacies, the drug is sold in cardboard packaging, which contains from four to twenty-four pieces. The price of tablets varies from 56 to 165 rubles and is available without a prescription. The Pentalgin N package contains ten tablets, the cost is from 169 rubles to 220 rubles, sold only with a prescription.

Pentalgin is a combination drug from the group of non-selective NSAIDs (non-steroidal anti-inflammatory drug), an inhibitor of cyclooxygenase (COX-1 and COX-2). The composition includes 5 substances that complement each other's actions: paracetamol, metamizole, phenobarbital, codeine and caffeine. Release forms:

• Tablets Pentalgin-IC, 10 tab. on the plate: paracetamol 200 mg, metamizole sodium (analgin) 300 mg, caffeine 20 mg, phenobarbital 10 mg and codeine 9.5 mg
• Tablets Pentalgin-ICN, 12 tab. on the plate: paracetamol 300 mg, metamizole sodium (analgin) 300 mg, caffeine 50 mg, phenobarbital 10 mg and codeine 8 mg
• Tablets Pentalgin-FS, 10 tab. on the plate: paracetamol 300 mg, metamizole sodium (analgin) 300 mg, caffeine 50 mg, phenobarbital 10 mg and codeine 8 mg

Indications for use of Pentalgin

Pentalgin is indicated for the following diseases of the spine and its structures:

• Spinal tumor (both benign and malignant)
• Spinal injuries (bruise, fracture, dislocation, etc.)
• Postoperative period

Contraindications

Pentalgin is contraindicated for the following diseases in the patient:

• Pregnancy
• Lactation period
• Children under 12 years old
• Allergy to the drug and its components
• Recent traumatic brain injury
• Anemia
• Increased intracranial pressure
• Glaucoma
• Episodes of bronchospasm of unknown etiology
• Ulcer in the intestines and stomach
• Respiratory failure
• Liver failure
• Kidney failure
• Diabetes mellitus
• Myocardial infarction, acute period
• High blood pressure numbers
• Glucose-6-phosphate dehydrogenase deficiency (hereditary congenital disease)
• Increased nervous excitability
• Drowsiness during the day and insomnia at night
• Arrhythmia
• Bronchial asthma

Operating principle

The action of Pentalgin is based on the complementarity of the constituent active substances. Paracetamol and metamizole are NSAIDs with non-selective blockade of COX-1 and COX-2, which allows you to stop the production of prostaglandins (inflammatory mediators) and reduce pain and inflammation.

Phenobarbital has a mild sedative effect, and also relieves spasm in vascular smooth muscles and striated muscles of the back, and enhances the effect of NSAIDs.

Caffeine stimulates the nervous system, accelerates blood flow and enhances the effect of paracetamol and metamizole.

Codeine is a narcotic analgesic, has pronounced analgesic and antitussive effects, and enhances the effect of phenobarbital and NSAIDs.

As a result, the patient feels an immediate reduction in pain in the spine, after a few days of use, tissue inflammation and swelling decreases, the amplitude of active and passive movements in the back is restored, and the patient returns to the usual lifestyle that he led before the exacerbation of the disease.

How to use Pentalgin

Pentalgin should be taken orally with a sufficient amount of liquid, 1-2 tablets 1-3 times a day. Taking with food or in the first 15-20 minutes after a meal improves the absorption of the drug in the gastrointestinal tract. The maximum daily dosage is 4-5 tablets. The course of treatment is up to 5 days. If necessary, you can extend treatment under the control of blood tests (general analysis and liver tests) or repeat it at the next exacerbation of the disease.

Side effects

Side effects of Pentalgin develop quite rarely:

• Rash and itching on the skin
• Dry mouth
• Increased heart rate (tachycardia)
• Abdominal pain
• Decreased appetite
• Nausea
• Vomit
• Headache
• Trembling hands
• Increased sleepiness
• Rapid heartbeat
• Constipation
• Deterioration of visual acuity
• Quincke's edema (angioedema)
• Dizziness
• Edema
• Kidney failure
• Liver failure

All side effects from the use of Pentalgin require discontinuation of the drug and the use of symptomatic medications.

If the prescribed dosage of Pentalgin is not observed and it is exceeded several times per day, signs of overdose may develop:

• Marked general weakness
• Severe nausea and vomiting
• Lower blood pressure
• Respiratory depression
• Pale skin
• Arrhythmia
• Acute liver failure
• Severe abdominal pain
• Tachycardia (rapid heartbeat)

In case of an overdose of Pentalgin, you should urgently rinse your stomach, consult a doctor, take enterosorbents and symptomatic medications.

Special instructions

During pregnancy of any gestational age and during breastfeeding, taking Pentalgin is strictly contraindicated due to the negative effect of the drug on the fetus and infant (inhibits breathing and organ formation).

Children under 12 years of age should not take Pentalgin due to possible depression of the respiratory center.

Alcoholic drinks can reduce or interfere with the effect of the drug and cause side effects, so it is recommended not to drink alcohol for 3 hours after taking Pentalgin. After the last drink, 2 to 8 hours should also pass (the stronger the drink, the more time you need to wait).

Pentalgin is a widely used drug that is found in almost everyone's medicine cabinet. It is an analgesic with analgesic, anti-inflammatory and antispasmodic effects. It is so popular due to its availability, speed and complex effect on the human body. The presence of a number of active substances in the composition has made it effective in treating such common problems as fever, pain of any etiology, and spasms. Its use helps not only to relieve discomfort, but also such unpleasant consequences as swelling and inflammation.

New Pentalgin does not contain codeine and is available without a prescription.

Pentalgin: instructions for use

Consult your doctor! Usually the drug is taken orally, one tablet 1-3 times a day. The maximum dose per day is four tablets. Treatment is allowed for no more than three days to eliminate fever, and no longer than five days for pain. The exact dosage must be prescribed by a doctor.

The effectiveness of the drug lies in its unique composition, which incorporates the following components that have proven themselves in the treatment of common ailments: paracetamol, naproxen, phenobrabital, caffeine, drotaverine, pheniramine. Thanks to such a rich composition, taking Pentalgin helps to overcome pain of any nature and varying intensity:

• for radiculitis, neuralgia;
• toothache;
• spasms of smooth muscles (renal colic, cholecystitis, etc.);
• colds and infections accompanied by fever;
• pain resulting from injuries and surgery.

Can children and adolescents take Pentalgin?

The drugs Pentalgin-N, Pentalgin Plus and Pentalgin-ICN are approved for use in adults and children over 12 years of age, Pentalgin is approved for use only in adults (over 18 years of age), because There have been no studies of the effectiveness and safety of the drug in childhood and adolescence.