Active ingredient

Pharmacological group

Nosological classification (ICD-10)

Composition and release form

1 ampoule with lyophilized powder for preparation injection solution contains ascorbic acid 0.05 g, complete with water for injection, in ampoules of 2 ml; There are 5 sets in the package.

Pharmacological action

Participates in regulation carbohydrate metabolism redox processes, blood clotting, capillary permeability, tissue regeneration, synthesis steroid hormones, collagen, procollagen.

Indications for the drug Ascorbic acid with glucose

Vitamin deficiency and hypovitaminosis C; hemorrhagic diathesis, bleeding (nasal, pulmonary, hepatic, uterine, caused by radiation sickness); overdose of anticoagulants; infectious diseases and intoxications; Addison's disease, nephropathy of pregnancy; slow-healing wounds and bone fractures; dystrophy; mental and physical stress.

Side effects

Inhibition of the function of the pancreatic insular apparatus (with long-term use).

Directions for use and doses

IM, IV, before administration, the lyophilized powder is dissolved in 1-2 ml of sterile water for injection, for adults - 1-3 ml of a 5% solution (2-6 ml of a 2.5% solution) per day; children - 1-2 ml of a 5% solution (2-4 ml of a 2.5% solution) per day.

Precautions

Prescribe with caution in case of increased blood clotting, thrombophlebitis, tendency to thrombosis, diabetes mellitus. It is necessary to monitor renal function and blood pressure, especially when prescribing large doses.

Storage conditions for the drug Ascorbic acid with glucose

Keep out of the reach of children.

Shelf life of the drug Ascorbic acid with glucose

lyophilisate for the preparation of solution for intravenous and intramuscular injection 0.05 g - 2 years.

tablets 100 mg + 877 mg 100 mg + 877 - 1 year.

tablets 50 mg - 1.5 years.

Do not use after the expiration date stated on the package.

Prices in Moscow pharmacies

The information provided on drug prices does not constitute an offer to sell or purchase goods.

The information is intended solely for comparison of prices in stationary pharmacies operating in accordance with Article 55 Federal Law“On the circulation of medicines” dated April 12, 2010 N 61-FZ.

tablets 100 mg + 877 mg 100 mg + 877, 10 pcs.

tablets 100 mg + 877 mg 100 mg + 877, 40 pcs.

Glucose dropper with ascorbic acid dosage

in pharmacies in Belarus

(information for specialists)

By medical use medicine

Agreed by the Ministry of Health of the Republic of Belarus

Order No. 393 of 04/14/2015

Trade name: Glucose.

International nonproprietary name: Carbohydrates.

Release form: solution for infusion 50 mg/ml or 100 mg/ml.

Description: transparent colorless or slightly yellowish color solution.

Composition per bottle:

solution 50 mg/ml:

active substance: anhydrous glucose – 20.0 g;

excipient: water for injections.

solution 100 mg/ml:

active substance: anhydrous glucose – 40.0 g;

excipients: hydrochloric acid 0.1 M solution, sodium chloride, water for injection.

Pharmacotherapeutic group: Solutions for intravenous administration. Solutions for parenteral nutrition.

Plasma replacement, rehydrating, metabolic and detoxification agent. The mechanism of action is due to the substrate inclusion of glucose in the processes of energy (glycolysis) and plastic (transamination, lipogenesis, nucleotide synthesis) metabolism.

Participates in various metabolic processes in the body, enhances redox processes in the body, improves the antitoxic function of the liver. Glucose, entering tissues, is phosphorylated, turning into glucose-6-phosphate, which is actively involved in many parts of the body’s metabolism. When glucose is metabolized in tissues, a significant amount of energy is released, which is necessary for the functioning of the body.

A 100 mg/ml glucose solution is hypertonic in relation to blood plasma, having increased osmotic activity. At intravenous administration increases the release of tissue fluid into the vascular bed, increases diuresis, increases excretion toxic substances with urine, improves the antitoxic function of the liver.

When diluted to an isotonic state (50 mg/ml solution), it replenishes the volume of lost fluid and maintains the volume of circulating plasma.

The theoretical osmolality of a glucose solution of 50 mg/ml is 287 mOsm/kg.

Theoretical osmolality of glucose solution 100 mg/ml - 602 mOsm/kg

When administered intravenously, the glucose solution quickly leaves the vascular bed.

Transport into the cell is regulated by insulin. In the body we undergo biotransformation along the hexose phosphate pathway - the main path of energy metabolism with the formation of high-energy compounds (ATP) and the pentose phosphate pathway - the main

the path of plastic metabolism with the formation of nucleotides, amino acids, glycerol.

Glucose molecules are utilized in the process of providing energy to the body. Glucose, entering the tissues, is phosphorylated, turning into glucose-6-phosphate, which is subsequently included in metabolism (the end products of metabolism are carbon dioxide and water). Easily penetrates through histohematic barriers into all organs and tissues.

It is completely absorbed by the body and is not excreted by the kidneys (appearance in urine is a pathological sign).

Indications for use

A glucose solution of 50 mg/ml is used to replenish fluid volume during cellular and general dehydration, and during extracellular hyperhydration.

Glucose solution 100 mg/ml is used for hypoglycemia and liver diseases (hepatitis, cirrhosis, hepatic coma), for the purpose of osmotherapy with insufficient diuresis, collapse and shock, with severe infectious diseases, decompensation of cardiac activity, various intoxications (poisoning with drugs, cyanides, carbon monoxide, etc.), with hemorrhagic diathesis, for parenteral nutrition.

Glucose solutions can be used either independently or, if indicated, in combination with other medicinal substances(sodium chloride, potassium chloride, NaEDTA, etc.), and also be used for diluting drugs.

Directions for use and dosage regimen

Before administration, the doctor is required to conduct a visual inspection of the bottle of medication. The solution must be clear and free of suspended particles or sediment. The medicinal product is considered suitable for use if the label is present and the packaging is sealed.

The concentration and volume of glucose solution administered for intravenous infusion is determined by a number of factors, including age, body weight and clinical condition patient. It is recommended to periodically determine blood glucose levels.

Isotonic solution 50 mg/ml administered intravenously by drip with a recommended injection rate of 70 drops/minute (3 ml/kg body weight per hour).

Hypertonic solution 100 mg/ml administered intravenously at a recommended injection rate of 60 drops/minute (2.5 ml/kg body weight per hour).

It is allowed to administer solutions of 50 mg/ml and 100 mg/ml glucose intravenously in a stream of 10-50 ml.

In adults with normal metabolism, the daily dose of administered glucose should not exceed 1.5-6 g/kg body weight per day (with a decrease in metabolic rate daily dose decrease), while the daily volume of administered fluid is 30-40 ml/kg.

For children for parenteral nutrition, along with fats and amino acids, 6 g/kg/day is administered on the first day, subsequently up to 15 g/kg/day. When calculating the dose of glucose when administering solutions of 50 mg/ml and 100 mg/ml dextrose, you need to take into account the permissible volume of administered fluid: for children with a body weight of 2-10 kg - 100-165 ml/kg/day, for children with a body weight 10-40 kg - 45-100 ml/kg/day.

When using a glucose solution as a solvent, the recommended dose is 50-250 ml per dose of the drug being dissolved, the characteristics of which determine the rate of administration.

Adverse reactions at the injection site: pain at the injection site, venous irritation, phlebitis, venous thrombosis.

Violations by endocrine system and marksmanship: hyperglycemia, hypokalemia, hypophosphatemia, hypomagnesemia, acidosis.

Violations by digestive tract: polydipsia, nausea.

General reactions of the body: hypervolemia, allergic reactions(increase in body temperature, skin rashes, hypervolemia).

In case of adverse reactions administration of the solution should be stopped, the patient's condition assessed and assistance provided. The remaining solution should be retained for later analysis.

Hypersensitivity, hyperglycemia, hyperlactic acidemia, hyperhydration, post-operative disorders of glucose utilization; circulatory disorders that threaten cerebral and pulmonary edema; cerebral edema, pulmonary edema, acute left ventricular failure.

C caution: decompensated chronic heart failure, chronic renal failure (oligo-, anuria), hyponatremia, diabetes mellitus.

Overdose can cause hyperglycemia, hyperhydration, hypervolemia, hypokalemia.

Therapy depends on the type and severity of the disorders: stopping the infusion, prescribing insulin (1 unit of insulin per 4-5 g of glucose), diuretics, electrolytes.

For more complete absorption of glucose introduced into large doses, at the same time insulin is prescribed at the rate of 1 unit of insulin per 4-5 g of glucose. For diabetic patients, glucose is administered under the control of its content in the blood and urine. During treatment it is necessary to monitor the ionogram.

The use of glucose in patients with acute ischemic stroke may slow down the healing process.

To avoid hyperglycemia, the level of possible glucose oxidation should not be exceeded.

Glucose solution should not be administered quickly or long time. If shivering occurs during administration, administration should be stopped immediately. To prevent thrombophlebitis, it should be administered slowly through large veins.

At renal failure, decompensated heart failure, hyponatremia required special care when prescribing glucose, monitor central hemodynamic parameters.

Use during pregnancy and lactation. Glucose solution for infusion should be administered with caution to women during pregnancy and lactation.

Impact on the ability to drive vehicles and other potentially dangerous mechanisms. No effect.

Interaction with others medicines

When combined with other drugs, it is necessary to clinically monitor their possible incompatibility (invisible pharmaceutical or pharmacodynamic incompatibility is possible).

Glucose solution should not be mixed with alkaloids (their decomposition occurs), with general anesthetics (decreased activity), with sleeping pills (decreased their activity).

Glucose weakens the activity of analgesics and adrenomimetic drugs, inactivates streptomycin, and reduces the effectiveness of nystatin.

Due to the fact that glucose is a fairly strong oxidizing agent, it should not be administered in the same syringe with hexamethylenetetramine.

Under the influence of thiazide diuretics and furosemide, glucose tolerance decreases.

Glucose solution reduces the toxic effect of pyrazinamide on the liver. The administration of a large volume of glucose solution contributes to the development of hypokalemia, which increases the toxicity of simultaneously prescribed digitalis drugs.

Glucose is incompatible in solutions with aminophylline, soluble barbiturates, erythromycin, hydrocortisone, warfarin, kanamycin, soluble sulfonamides, cyanocobalamin.

Glucose solution should not be administered in the same infusion system with blood due to the risk of nonspecific agglutination.

Since the glucose solution is for intravenous infusions has an acidic reaction (pH<7), может возникнуть несовместимость при одновременном введении с другими лекарственными средствами.

Store at a temperature not exceeding 25 ºС.

Keep out of the reach of children.

Do not use after the expiration date stated on the packaging.

400 ml glass bottles for blood, transfusion and infusion drugs. Each bottle, along with instructions for use, is placed in a pack.

For delivery to hospitals: 24 bottles along with an appropriate number of instructions for use in corrugated cardboard boxes.

Release from pharmacies

All rights belong to RUE Belmedpreparaty.

When using portal materials in whole or in part for other purposes, a link to the source is required!

Take orally after meals. The duration of the course is determined by the doctor.

Ascorbic acid with glucose instructions for use for children

Take orally after meals, under adult supervision. The dosage form is not prescribed to children under 6 years of age.

How to take ascorbic acid with glucose for pregnant women

Ascorbic acid with glucose during pregnancy should be used taking into account the benefit/harm ratio, as prescribed by a doctor.

In 2-3 trimesters, the dose of 100 mg/day is not allowed to be exceeded;
During lactation it increases to 120 mg/day.

Ascorbic acid with glucose dosage

For adults Prescribe 0.5-1 tablet 1 time per day for prevention, and 0.5-1 tablet 3-4 times per day for treatment.
For children Prescribe half a tablet once a day for prevention and 0.5-1 tablet 2-3 times a day for treatment.

Ascorbic acid with glucose tablets composition

In terms of pure substance one tablet contains 100 mg of ascorbic acid and 877 mg of glucose.

Additional components: starch, talc, stearic acid.

Release form

Produced in white, flat cylindrical tablets with a separation line, 10 pieces per blister, in cell or cell-free contour packaging.

Vitamin C preparations

What are the benefits of ascorbic acid with glucose?

Ascorbic acid regulates the intensity of metabolism, participates in redox processes, the metabolism of proteins and carbohydrates. Glucose supplies tissues with energy and has a detoxification function. How the drug affects the body systems:
Immune

the immune response and resistance to disease increases;
the occurrence of infections is prevented;
accelerates the healing of wounds and fractures;
the restoration of antioxidants – retinol and tocopherol – is activated.

Cardiovascular and circulatory

toxic substances in the blood are neutralized;
hemoglobin formation increases;
the level of “bad” cholesterol in the blood decreases and the content of “good” increases;
the permeability of the walls of small vessels is normalized;
blood clotting increases.

Digestive

the process of absorption of iron from the intestines is facilitated;
the synthesis and secretion of bile increases;
the antitoxic activity of the liver increases;
the synthesis of digestive tract enzymes is accelerated;
the need for thiamine, retinol, tocopherol, folic and pantothenic acids is reduced;
liver production of building proteins increases.

Endocrine

the formation of hormones is normalized;
insulin secretion increases;
The endocrine function of the thyroid gland increases.

Pharmacodynamics and pharmacokinetics

Vitamin C is absorbed from the duodenum and jejunum, and 30-40 minutes after administration, its active uptake into tissues begins. The distribution is uneven; ascorbic acid accumulates most in the endocrine organs, liver, myocardium and striated muscles.

Vitamin C is absorbed by tissues in the form of three compounds - ascorbigen, ascorbic and dehydroascorbic acids. It is excreted in urine in pure form and in the form of oxalate.

Glucose is quickly absorbed in the small intestine and, with the help of insulin, is absorbed into tissues. Metabolized by glycolysis and aerobic oxidation. As a result, an energy substrate is formed - adenosine triphosphate (ATP), carbon dioxide and water.

Ascorbic acid with glucose indications for use

Indications

hypovitaminosis C;
malnutrition;
heavy physical and mental stress;
recovery after illnesses and operations;
alcohol, nicotine and drug addiction;
overdose of blood thinning drugs;
poisoning;
slow healing wounds and fractures;
pregnancy and lactation;
period of active growth;
nervous and physical exhaustion;
infections;
prevention of colds;
anemia;
intoxication with iron preparations.

Ascorbic acid with glucose contraindications

Contraindications

hypersensitivity to components;
thrombophlebitis;
predisposition to thrombosis;
diabetes mellitus;
Use with caution in cases of glucose-6-phosphate dehydrogenase deficiency, hemochromatosis and kidney stones.

Side effects

After taking ascorbic acid with glucose in tablets, the following phenomena may be observed in certain body systems:
Endocrine system

decreased insulin synthesis.

Skin and mucous membranes

rash;
redness and itching of local areas of the skin;
irritation of the gastric mucosa.

Digestive system

nausea and vomiting;
diarrhea;
cramping pain in the upper abdomen.

Cardiovascular and circulatory system

increased blood pressure;
increased blood glucose levels;
thrombocytosis;
decreased potassium content;
decrease in the number of red blood cells;
hyperprothrombinemia.

Nervous system

irritability;
fatigue;
depression.

Special instructions

With long-term use, kidney function and blood pressure should be monitored. Possible decrease in insulin synthesis. If there is excess iron in the body, ascorbic acid with glucose is prescribed in a minimal dose.

When conducting laboratory tests, it is necessary to take into account the distortions that ascorbic acid may produce. In patients with malignant neoplasms, their growth may accelerate. If you have diabetes, you must take into account that one tablet contains 877 mg of glucose.

Ascorbic acid with glucose - benefits and harms of using with other drugs

Ascorbic acid with glucose enhances the absorption of estradiol, iron, penicillin and tetracycline antibiotics from the intestine. Increases the overall clearance of ethanol and reduces the effect of antidepressants.

Vitamin C slows down the removal of acids from the body, accelerating the removal of alkaline drugs. Calcium supplements and corticosteroid hormones reduce the concentration of ascorbic acid in the blood. Barbiturates accelerate the metabolism of vitamin C.

Overdose of ascorbic acid with glucose

Cases of acute overdose are unknown. Long-term overdose can lead to:
Overdose

deterioration of capillary permeability and histohematic (standing in the way of blood to tissues) barriers;
blurred vision;
increased prothrombin levels in the blood;
disruption of the blood supply to the heart muscle;
decrease in dehydrogenase activity.
nausea and vomiting;
diarrhea;
skin rashes and itching;
increased blood pressure;
inhibition of pancreatic and kidney function.

In case of overdose, you must stop taking ascorbic acid with glucose and consult a doctor. At home, you should induce vomiting, then drink a large amount of alkaline drink and take sorbents (activated carbon, enterosgel).

Terms of sale

Over-the-counter sale in pharmacies is permitted.

Storage conditions and shelf life

Store in a dark and dry place, out of reach of children, at a temperature of 15 to 25°C.

Manufacturer: Eikos-Farm TOO

Anatomical-therapeutic-chemical classification: Ascorbic acid in combination with other drugs

Registration number: No. RK-LS-5 No. 015550

Registration date: 13.03.2017 - 13.03.2022

Instructions

Russian

Trade name

Ascorbic acid with glucose

International nonproprietary name

Dosage form

Pills

Compound

One tablet contains

active substances: ascorbic acid - 50 mg

glucose monohydrate - 483 mg

(in terms of glucose 100% 439 mg)

excipients: potato starch, talc, calcium stearate.

Description

The tablets are round, flat, white, with beveled edges and scored on one side.

Pharmacotherapeutic group

Ascorbic acid in combination with other drugs.

ATX code A11GВ

Pharmacological properties

Pharmacokinetics

After oral administration, ascorbic acid is completely absorbed from the gastrointestinal tract and widely distributed in the tissues of the body. The normal concentration of ascorbic acid in blood plasma is approximately 10-20 mcg/ml. The depot level in the body is about 1.5 g. The concentration of ascorbic acid in leukocytes and platelets is higher than in erythrocytes and plasma. In deficiency states, leukocyte concentrations decline later and more slowly and are considered a better measure of deficiency than plasma concentrations.

Plasma protein binding is about 25%.

Ascorbic acid is reversibly oxidized to form dehydroascorbic acid, some is metabolized to form ascorbate-2-sulfate, which is inactive and excreted in the urine.

Ascorbic acid, taken in excessive quantities, is quickly excreted unchanged in the urine, usually when the daily dose is exceeded.

Absorption of ascorbic acid is reduced by simultaneous consumption of fresh fruit and vegetable juices and alkaline drinks.

Glucose is easily absorbed and quickly distributed in all tissues of the body. The main metabolic pathways are glycolysis and aerobic oxidation to carbon dioxide and water, resulting in the formation of ATP and other high-energy compounds.

Pharmacodynamics

Ascorbic acid is involved in redox reactions, tyrosine metabolism, the conversion of folic acid into folinic acid, carbohydrate metabolism, lipid and protein synthesis, iron metabolism, cellular respiration processes, blood clotting, normalization of capillary permeability, and contributes to the formation of resistance to infections. Reduces the need for vitamins B1, B2, A, E, folic acid, pantothenic acid, helps increase the body's resistance; improves iron absorption, promoting its deposition in a reduced form, has antioxidant properties. Ascorbic acid is necessary for the formation of intracellular collagen and is required to strengthen the structure of teeth, bones and capillary walls.

Glucose takes part in carbohydrate and energy metabolism, improves the detoxification potential of the body, thus optimizing a number of its functions. When glucose is metabolized in tissues, a significant amount of energy is released, which is necessary for the functioning of the body.

Indications for use

Prevention and treatment of hypo- and avitaminosis of vitamin C. Ensuring the body’s increased need for vitamin C and glucose during:

Growth period

Pregnancy and lactation

Heavy physical and mental stress

Overworked

The period of recovery after long, serious illnesses

Postoperative period

Stressed state

In winter, there is an increased risk of developing infectious diseases.

Directions for use and doses

Inside, after eating.

For the prevention of hypovitaminosis C, adults 50-100 mg/day (1-2 tablets).

Children: 6-14 years old - 50 mg/day (1 tablet), 14-18 years old - 75 mg/day (1.5 tablets).

During pregnancy and lactation - 300 mg/day (6 tablets) for 10-15 days, then 100 mg/day (2 tablets) throughout the entire lactation period. For therapeutic purposes: children 50-100 mg (1-2 tablets) 2-3 times a day, adults 50-100 mg (1-2 tablets) 3-5 times a day for 2 weeks. The maximum daily dose for adults is 1000 mg (20 tablets). The duration of treatment depends on the nature and course of the disease.

Side effects

Hyperglycemia

Glucosuria, inhibition of glycogen synthesis

Arterial hypertension

Nausea, vomiting, heartburn, diarrhea, cramping pain in the epigastrium

Headache, feeling tired

Skin rash

Transient decrease in urine pH

Inhibition of the function of the pancreatic insular apparatus

Depression of kidney function

Allergic reactions

Hypervitaminosis

With long-term use of large doses - increased excitability of the central nervous system, sleep disturbance

Laboratory indicators

Thrombocytosis

Hyperprothrombinemia

Erythropenia

Neutrophilic leukocytosis

Hypokalemia

Formation of urinary, cystine and oxalate stones in the kidneys.

Contraindications

Hypersensitivity to the components of the drug

Increased blood clotting

Thrombophlebitis, tendency to thrombosis

Diabetes mellitus

Glucose-6-phosphate dehydrogenase deficiency.

Kidney failure

Hemochromatosis

Thalassemia

Children under 6 years old

Drug interactions

Aluminum-containing antacids

The simultaneous use of aluminum-containing antacids and ascorbic acid is not recommended, as it can lead to the accumulation of toxicity in bone tissue and the central nervous system.

Salicylates

Increases the concentration of salicylates in the blood and increases the risk of developing oxalaturia.

Disulfiram

In some cases, ascorbic acid can be used as a specific antidote to eliminate the symptoms of interaction between ethanol and disulfiram. It should be expected that concomitant use of ascorbic acid will inhibit the effectiveness of disulfiram when used in patients with withdrawal symptoms.

Drugs that affect the acidity of urine (for example, amphetamine, mexiletine)

Increased urine acidity by ascorbic acid may cause precipitation of cysteine, uric acid, or oxalate stones and alters the excretion of some other drugs administered concomitantly. The excretion of some drugs may be increased by increasing the acidity of the urine. The patient's condition should be constantly monitored. If an interaction reaction is observed, it is necessary to decide whether to discontinue or adjust the dose of ascorbic acid. Warfarin Large doses of ascorbic acid reduce the effect of the anticoagulant warfarin. It is necessary to monitor coagulation parameters in patients receiving daily ascorbic acid at a dose of 5 g or more and adjust the dose of warfarin accordingly.

Increases absorption ethinyl estradiol, tetracycline and penicillins.

Promotes absorption gland and its deposit in restored form.

Amphetamine/dextroamphetamine/benzphetamine

Using ascorbic acid with dextroamphetamine, amphetamine, or benzphetamine may reduce the effects of these drugs. Do not stop using medications without consulting a doctor.

Ascorbic acid and combined oral contraceptives mutually reduce each other's concentration.

When used simultaneously with deferoxamine potentiates its effect and increases iron excretion.

Smoking and ethyl alcohol accelerate the metabolism of ascorbic acid and reduce its content in the body.

Special instructions

Due to the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor adrenal function and blood pressure.

With long-term use of large doses, inhibition of the function of the pancreatic insular apparatus is possible, so it must be regularly monitored during treatment.

Since ascorbic acid increases iron absorption, its use in high doses can be dangerous in patients with hemochromatosis, thalassemia, polycythemia, leukemia, and sideroblastic anemia. Patients with high iron levels in the body should take ascorbic acid in minimal doses. The use of ascorbic acid in high doses can cause an exacerbation of sickle cell anemia.

Pregnancy and lactation

Use with caution during pregnancy, since high doses of vitamin C more than 1 g per day can cause abortion due to increased estrogen synthesis. Use during pregnancy and lactation after consultation with a doctor.

Features of the drug's influence on the ability to drive a vehicle or potentially dangerous mechanisms.

In therapeutic doses, ascorbic acid with glucose does not affect the ability to drive a car or drive potentially dangerous mechanisms.

Overdose

Symptoms: nausea, vomiting, shortness of breath, decreased blood pressure, arrhythmias, acute left ventricular failure (ALVF).

Treatment: gastric lavage, monitoring kidney function and blood pressure, symptomatic therapy.

Release form and packaging

10 tablets in a contoured, cell-free package made of polymer-coated paper. Contour cellless packages, together with instructions for medical use in the state and Russian languages, are placed in a cardboard box (multiple packaging). The number of instructions must correspond to the number of packages. 50 tablets in polyethylene jars with polypropylene lids. 250 contour packages or 20 cans each, along with instructions for medical use in the state and Russian languages, are placed in a cardboard box.

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C.

Keep out of the reach of children!

Shelf life

Do not use after expiration date.

Conditions for dispensing from pharmacies

Over the counter

Manufacturer

Eikos-Pharm LLP, Kazakhstan, Almaty region, Ili district, village. Boraldai, 71 crossing point.

Registration Certificate Holder

Eikos-Pharm LLP, Kazakhstan

Address of the organization that receives complaints from consumers regarding the quality of products (goods) on the territory of the Republic of Kazakhstan, and is responsible for post-registration monitoring of the safety of the medicinal product

Almaty, st. Nusupbekova, 32

tel: 397 64 29, fax: 250 71 78,

e-mail: [email protected]

Attached files

248956981477976491_ru.doc	63.5 kb
249621921477977659_kz.doc	70 kb

Take orally after meals. The duration of the course is determined by the doctor.

Ascorbic acid with glucose instructions for use for children

Take orally after meals, under adult supervision. The dosage form is not prescribed to children under 6 years of age.

How to take ascorbic acid with glucose for pregnant women

Ascorbic acid with glucose during pregnancy should be used taking into account the benefit/harm ratio, as prescribed by a doctor.

In 2-3 trimesters, the dose of 100 mg/day is not allowed to be exceeded;
During lactation it increases to 120 mg/day.

Ascorbic acid with glucose dosage

For adults Prescribe 0.5-1 tablet 1 time per day for prevention, and 0.5-1 tablet 3-4 times per day for treatment.
For children Prescribe half a tablet once a day for prevention and 0.5-1 tablet 2-3 times a day for treatment.

Ascorbic acid with glucose tablets composition

In terms of pure substance one tablet contains 100 mg of ascorbic acid and 877 mg of glucose.

Additional components: starch, talc, stearic acid.

Release form

Produced in white, flat cylindrical tablets with a separation line, 10 pieces per blister, in cell or cell-free contour packaging.

Vitamin C preparations

What are the benefits of ascorbic acid with glucose?

the immune response and resistance to disease increases;
the occurrence of infections is prevented;
accelerates the healing of wounds and fractures;
the restoration of antioxidants – retinol and tocopherol – is activated.

Cardiovascular and circulatory

toxic substances in the blood are neutralized;
hemoglobin formation increases;
the level of “bad” cholesterol in the blood decreases and the content of “good” increases;
the permeability of the walls of small vessels is normalized;
blood clotting increases.

Digestive

the process of absorption of iron from the intestines is facilitated;
the synthesis and secretion of bile increases;
the antitoxic activity of the liver increases;
the synthesis of digestive tract enzymes is accelerated;
the need for thiamine, retinol, tocopherol, folic and pantothenic acids is reduced;
liver production of building proteins increases.

Endocrine

the formation of hormones is normalized;
insulin secretion increases;
The endocrine function of the thyroid gland increases.

Pharmacodynamics and pharmacokinetics

Vitamin C is absorbed by tissues in the form of three compounds - ascorbigen, ascorbic and dehydroascorbic acids. It is excreted in urine in pure form and in the form of oxalate.

Ascorbic acid with glucose indications for use

Indications

hypovitaminosis C;
malnutrition;
heavy physical and mental stress;
recovery after illnesses and operations;
alcohol, nicotine and drug addiction;
overdose of blood thinning drugs;
poisoning;
slow healing wounds and fractures;
pregnancy and lactation;
period of active growth;
nervous and physical exhaustion;
infections;
prevention of colds;
anemia;
intoxication with iron preparations.

Ascorbic acid with glucose contraindications

Contraindications

hypersensitivity to components;
thrombophlebitis;
predisposition to thrombosis;
diabetes mellitus;
Use with caution in cases of glucose-6-phosphate dehydrogenase deficiency, hemochromatosis and kidney stones.

Side effects

After taking ascorbic acid with glucose in tablets, the following phenomena may be observed in certain body systems:
Endocrine system

decreased insulin synthesis.

Skin and mucous membranes

rash;
redness and itching of local areas of the skin;
irritation of the gastric mucosa.

Digestive system

nausea and vomiting;
diarrhea;
cramping pain in the upper abdomen.

Cardiovascular and circulatory system

increased blood pressure;
increased blood glucose levels;
thrombocytosis;
decreased potassium content;
decrease in the number of red blood cells;
hyperprothrombinemia.

Nervous system

irritability;
fatigue;
depression.

Special instructions

Ascorbic acid with glucose - benefits and harms of using with other drugs

Overdose of ascorbic acid with glucose

Cases of acute overdose are unknown. Long-term overdose can lead to:
Overdose

deterioration of capillary permeability and histohematic (standing in the way of blood to tissues) barriers;
blurred vision;
increased prothrombin levels in the blood;
disruption of the blood supply to the heart muscle;
decrease in dehydrogenase activity.
nausea and vomiting;
diarrhea;
skin rashes and itching;
increased blood pressure;
inhibition of pancreatic and kidney function.

Terms of sale

Over-the-counter sale in pharmacies is permitted.

Storage conditions and shelf life

Store in a dark and dry place, out of reach of children, at a temperature of 15 to 25°C.

If the solution has a concentration of 10%, then the injection rate should be 3 ml per minute, and the maximum daily dose should be 1 liter. Glucose 20% is administered very slowly, about 1.5-2 ml per minute, the daily dose is 500 ml. In any case, you will not be able to administer intravenous drips yourself, so go to the hospital for the procedure.

You can administer subcutaneous ones yourself. To do this, buy syringes and. Inject fractionally into different places, 300-500 ml per day. Use only hypodermic syringes; regular intramuscular ones have too thick a needle and deform the skin to a greater extent.

Give an enema if all other methods for some reason do not suit you. Inject up to 2 liters of solution per day (isotonic) into the anus.

Please note

When administered subcutaneously, side effects may occur in the form of tissue necrosis. And as a result of rapid injection of glucose solution into a vein, phlebitis may begin. Therefore, do not self-medicate, especially if you do not understand anything about it. Trust your health to doctors.

Useful advice

Glucose is contraindicated in diabetes, but in some cases it is administered together with insulin exclusively in a hospital setting.

Sources:

how to inject glucose

Subcutaneous injections are done when an immediate effect from the medicine is not required. And at the same time, such injections begin to act faster than taking a pill. The fact is that in the subcutaneous fat layer, where the injection is made, there are many blood vessels, so the medicine administered in this way is well absorbed into the blood. Typically, vaccinations are given subcutaneously and hormonal medications, such as insulin or growth hormone, are administered.

You will need

- 1 ml syringe;
- medicine;
- cotton ball or disk;
- alcohol.

Instructions

Wash your hands and wipe them with a cotton swab soaked in alcohol.

Lubricate the injection site with a cotton pad soaked generously in alcohol. First, treat a large area of skin around the injection site, then the injection site itself.

Make a triangle fold of skin with your left hand. Take the syringe in your right hand. If you are left-handed, then do the opposite. The syringe must be in the dominant hand for precise movements.

Insert the needle 2/3 of the way at an angle of 45 degrees into the base of the skin fold.

Remove the needle from the skin and apply a cotton pad soaked in alcohol to the injection site. Without removing the cotton from the skin, lightly massage the injection site in a circular motion.

Throw the syringe into the trash, after putting the cap on the needle.

Please note

Be careful not to get any air bubbles into the syringe when drawing the medicine. If this does happen, do not inject it under the skin. Leave an air bubble with a small amount of medicine in the syringe.

Sources:

how to do subcutaneous

Glucose is a source of valuable nutrition. It is easily absorbed by the body and increases its energy reserves. It is used as a general tonic for various diseases associated with depletion of the body, and is a component of blood replacement and anti-shock fluids. Glucose solutions are widely used for hypoglycemia, infectious diseases, liver diseases, decompensated heart failure, various intoxications, pulmonary edema and other diseases. Isotonic and hypertonic solutions of this substance are widely used in medicine.

Instructions

Isotonic glucose solutions (4.5 - 5%) are used to replenish body fluid losses during illness, for example, with prolonged diarrhea, large blood losses, or as a source of nutrition. Glucose, distributed in tissues, releases the energy necessary to restore the vitality of the body.
Isotonic glucose solutions are administered subcutaneously or rectally in the form of enemas. If the drug is used subcutaneously, glucose is infused in a stream, 300-500 ml or more per injection. For rectal administration - by 200, 500 and 1000 ml. The maximum amount consumed is 2 liters per day.
When administered intravenously by drip, the solution is delivered at a rate of up to 7 ml per minute (or 400 ml/hour), in a volume of 300 - 500 ml. The daily dose should also not exceed two liters.

Hypertonic (10, 20, 25 and 40%) glucose solutions are used to quickly remove toxins from the body through the kidneys, as well as to restore metabolic processes. When administered, the osmotic pressure of the blood increases, the contractile activity of the heart muscle increases, the blood vessels dilate, and diuresis increases.
Hypertonic solutions are administered, 10–100 ml per injection. Possibly funds in the form. The rate of administration of a 10% solution can reach up to 60 drops (3 ml) per minute. The permissible daily dose is 250-300 ml.

When using glucose for parenteral nutrition, the first administered dose should not exceed 6 mg of solution per 1 kg per day. With subsequent administrations - up to 15 ml/kg/day. The maximum permissible volume of liquid when administering 5% and 10% solutions from 2 to 10 kg is 100 - 165 ml/kg/day, with a weight from 10 to 40 kg - 45 -100 ml/kg/day. The rate of glucose administration for a 5% solution cannot be more than 10 ml (200 drops) per minute.

Please note

Glucose solutions are contraindicated in diabetes mellitus, hyperglycemia, circulatory disorders that threaten cerebral and/or pulmonary edema, hyperosmolar coma and other diseases. If, however, the drug is used for patients with diabetes, then it is administered carefully, constantly monitoring the glucose level in the blood and urine.

Useful advice

Typically, when large doses of glucose are administered, insulin is prescribed for better absorption in the body at a rate of 1 unit of the drug per 4-5 g of glucose.

Sources:

cytopsor.com

Carbohydrates entering the body are influenced by enzymes and converted into glucose. It is an important source of energy, and its role in the body is difficult to overestimate.

What is glucose needed for?

Glucose in the body is a source of energy. Very often, doctors use glucose to treat certain types of liver diseases. Doctors also often inject glucose into the human body in case of poisoning. It is administered by stream or using a dropper.

Glucose is also used to feed babies if for some reason they do not consume food. Glucose is able to cleanse the liver of waste and toxins. It restores lost liver functions and accelerates metabolism in the body.

With the help of glucose, medical workers relieve any type of intoxication. When additional energy enters the body, tissues and organs begin to work more actively. Glucose ensures complete burning of fats in the body.

It is imperative to monitor the level of glucose in the human body. A deficiency or excess of this substance indicates the presence of any disease in a person. The endocrine system controls glucose levels, and regulation is carried out by the hormone insulin.

Where is glucose found?

You can find high levels of glucose in grapes and other types of berries and fruits. Glucose is a type of sugar. In 1802, glucose was discovered by W. Prout. The industry is engaged in the production of glucose. It is obtained by processing starch.

In the natural process, glucose appears during photosynthesis. Not a single reaction in the body occurs without the participation of glucose. For brain cells, glucose is one of the main nutrients.

Doctors may prescribe glucose use for a variety of reasons. Very often, people start consuming glucose when they have hypoglycemia – a lack of glucose in the body. Sometimes poor nutrition can affect glucose levels in the body. For example, when a person gives preference to protein foods, the body lacks carbohydrates (fruits, cereals).

During poisoning, it becomes necessary to restore the cleansing function of the liver. Consuming glucose also helps here. In case of liver diseases, glucose is able to restore the working processes of its cells.

When vomiting or bleeding, a person may lose a lot of fluid. With the help of glucose, its level is restored.

In case of shock or collapse - a sharp decrease in blood pressure - the doctor may also prescribe additional glucose intake.

Glucose is also used for parenteral nutrition if for some reason a person cannot eat regular food. Sometimes glucose solution is added to medications.