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Egilok ® (Egilok ®)

Last update of the description by the manufacturer 11.09.2014

Show all release forms (14)

tablets (14)

tablets 25 mg; bottle (bottle) brown glass 60, carton pack 1; EAN code: 5995327166193; No. П N015639/01, 2009-03-17 from EGIS Pharmaceuticals PLC (Hungary) Egilok ®

tablets 50 mg; bottle (bottle) brown glass 60, carton pack 1; EAN code: 5995327166223; No. П N015639/01, 2009-03-17 from EGIS Pharmaceuticals PLC (Hungary) Egilok ®

tablets 100 mg; bottle (bottle) brown glass 60, carton pack 1; EAN code: 5995327166261; No. П N015639/01, 2009-03-17 from EGIS Pharmaceuticals PLC (Hungary) Egilok ®

tablets 100 mg; bottle (bottle) brown glass 30, carton pack 1; EAN code: 5995327114620; No. П N015639/01, 2009-03-17 from EGIS Pharmaceuticals PLC (Hungary) Egilok ®

Egilok ®

tablets 50 mg; bottle (bottle) brown glass 30, carton pack 1; EAN code: 5995327114217; No. П N015639/01, 2009-03-17 from EGIS Pharmaceuticals PLC (Hungary) Egilok ®

tablets 25 mg; blister 20, cardboard pack 3; No. П N015639/01, 2009-03-17 from EGIS Pharmaceuticals PLC (Hungary) Egilok ®

tablets 50 mg; blister 15, cardboard pack 4; No. П N015639/01, 2009-03-17 from EGIS Pharmaceuticals PLC (Hungary) Egilok ®

tablets 100 mg; bottle (bottle) brown glass 30, carton pack 1; No. П N015639/01, 2009-03-17 from EGIS Pharmaceuticals PLC (Hungary) Egilok ®

tablets 100 mg; plastic bag (bag) 12.8 kg, polypropylene container 1; No. П N015639/01, 2009-03-17 from EGIS Pharmaceuticals PLC (Hungary) Egilok ®

tablets 50 mg; bottle (bottle) brown glass 30, carton pack 1; No. П N015639/01, 2009-03-17 from EGIS Pharmaceuticals PLC (Hungary) Egilok ®

tablets 50 mg; plastic bag (bag) 12.8 kg, polypropylene container 1; No. П N015639/01, 2009-03-17 from EGIS Pharmaceuticals PLC (Hungary) Egilok ®

tablets 25 mg; bottle (bottle) brown glass 30, carton pack 1; No. П N015639/01, 2009-03-17 from EGIS Pharmaceuticals PLC (Hungary) Egilok ®

tablets 25 mg; plastic bag (bag) 14.3 kg, polypropylene container 1; No. П N015639/01, 2009-03-17 from EGIS Pharmaceuticals PLC (Hungary)

Egilok

Composition

Tablets of 25, 50, 100, 200 mg.

One tablet of Egilok, Egilok Retard contains 25, 50, 100 mg of the active substance ( metoprolol tartrate ) respectively.

One tablet of Egiloc C, the active substance (metoprolol succinate ) accounts for 23.75, 47.5, 95, 190 mg, respectively .

Excipients for Egilok, Egilok Retard: povidone . sodium carboxymethyl starch . magnesium stearate, microcrystalline cellulose, colloidal anhydrous silica.

Excipients for Egilok C: ethyl cellulose, microcrystalline cellulose, corn starch, metal cellulose, glycerol, magnesium stearate.

Release form

Packed in a cardboard box of 1, 2 and 3 blisters, 10 pcs. in each for 25mg, 50mg, 100mg, 200mg tablets.

Packed in a dark glass bottle: 30 and 60 pcs. for 25 mg, 50 mg and 100 mg tablets.

Round biconvex tablets, white or almost white color. Without smell. Volume: 25 mg, 50 mg, 100 mg.

• On a tablet Egilok 25 mg double beveled cross line on one side, E435 engraved on the other side.
• On a tablet Egilok 50 mg on one side of the risk, on the other side engraved E434.
• On a tablet Egilok 100 mg on one side of the risk, on the other side engraved E432.

Egilok Retard

White biconvex tablets round shape, on both sides of the risk. Volume 50 mg and 100 mg.

Biconvex tablets in white film shell oval shape. On both sides of the risk. Volume: 25 mg, 50 mg, 100 mg, 200 mg.

pharmachologic effect

Develops hypotensive, antiarrhythmic, antianginal and beta1-adrenergic blocking stimulation. Causes a rapid decrease in contractions in the heart muscle.

When sinus tachycardia on the background hyperthyroidism and functional problems with the heart, as well as with atrial fibrillation And supraventricular tachycardia the drug can significantly slow down the heart rate up to the restoration of sinus rhythm.

Unlike non-selective beta-blockers, the effect metoprolol on carbohydrate metabolism and insulin production is less significant.

Pharmacodynamics and pharmacokinetics

The drug has high speed absorption in the gastrointestinal tract. Within 1.5-2 hours after ingestion, Cmax in blood plasma is reached. Under the influence of the active substance is suppressed increased activity sympathetic system towards the heart. From what tablets Egilok with regular use cause lowering cholesterol in blood serum. The bioavailability of the drug increases by 30-40% if taken metoprolol along with food.

The impaired function of the kidneys and liver has practically no effect on the excretion and absorption of the active substance. However, with severe hepatic impairment ( cirrhosis . superimposed porto-caval shunt ) bioavailability increases significantly, and with chronic kidney failure increases the risk of unwanted side effects. In old age, the pharmacokinetics of the drug does not change significantly.

After use, the medicine passes full degree absorbability. Egilok has a weak binding to proteins in the blood plasma (no more than 10%). The drug is excreted from the body mainly in the form of metabolites, only 5% is excreted by the kidneys.

Indications for use Egilok

• prophylactic seizure prevention migraine ;
• high blood pressure;
• impaired functional cardiac activity;
• angina pectoris ;
• disturbed heartbeat(supraventricular tachycardia and bradycardia ventricular extrasystoles and atrial fibrillation)
• myocardial infarction .

Indications for the use of tablets also apply to people over 60 years of age.

Contraindications

• SSSU;
• cardiogenic shock ;
• pronounced bradycardia (less than 50 beats per minute);
• lactation period ;
• simultaneous reception of MAO inhibitors;
• age up to 18 years;
• hypersensitivity to the components of the drug in particular, or to beta-blockers in general;
• sinoatrial blockade;
• severely disturbed peripheral circulation;
• bronchial asthma in severe form;
• AV - blockade of 2 or 3 degrees.

Side effects

• In relation to the CNS: elevated threshold fatigue (very common), headaches and dizziness (often); infrequently - convulsions . weakened attention, depression, reinforced heart failure . nightmares; rarely - nervous excitability, anxiety state . sexual dysfunction . hallucinations . memory impairment.
• In relation to the senses (rarely): blurred vision .
• Towards digestive system(seldom): stomach ache . diarrhea . constipation . dryness in the area of ​​the mucous membrane in the oral cavity.
• Towards respiratory system: shortness of breath on exertion (often), rhinitis (seldom).
• Towards skin(infrequently): rash . increased sweating .

Instructions for use Egilok

Tablets are taken orally, washed down with a small amount of water. Reception is allowed both during meals (recommended), and on an empty stomach.

Instructions for Egilok Retard And Egilok. The dose is divided into two doses per day, morning and evening.

Instructions for Egilok S. take 1 time per day, in the morning.

How to take (the final dose size and number of doses) the medicine is determined by the doctor individually. Maximum dose 200 mg. With impaired renal function and with advanced age, redistribution of the volume of the drug consumed is not required.

• Heart failure with compensation: 25 mg per day.
• hyperthyroidism : 50-200 mg per day.
• Arrhythmia : 50-200 mg per day.
• angina pectoris : 50 mg per day.
• migraine attacks (prevention): 100-200 mg per day.
• Tachycardia : 50-200 mg per day.
• myocardial infarction (secondary prevention): 200 mg daily.

Find a doctor for treatment

Overdose

Excessive and inconsistent use of the drug with the doctor leads to an overdose, most clear symptom which is the reaction from of cardio-vascular system: slow pulse, heart failure. In some cases, when using the medicine by persons under 18 years of age, it is also possible backlash from the side of the central nervous system: increased fatigue, the occurrence of convulsions, excessive sweating, the onset of fatigue.

In case of an overdose, one or more of the above symptoms occur within 20-120 minutes, depending on the characteristics of the organism. High concentration metoprolol in the body, depending on the nature of the symptoms, it is eliminated by gastric lavage, symptomatic therapy, the appointment of adsorbents, atropine sulfate . gluconate . dopamine . norepinephrine .

The use of the drug Egilok with other medications

The list of prohibited drugs for simultaneous use with Egilok is wide. Therefore, special care should be taken to combine this medicine with third party medications.

When mixed with verapamil can cause cardiac arrest.

When mixed with beta-blockers ( estrogens . theophylline . indomethacin ) decreases the hypotensive property of metoprolol.

When mixed with ethanol, the pumping effect on the central nervous system is enhanced.

When mixed with oral hypoglycemic drugs and insulin increased likelihood of hypoglycemia .

When mixed with barbiturates (pentobarbital ) under the influence of enzyme induction, the metabolism of metoprolol is accelerated.

The drug Egilok is a drug from the group of so-called beta 1 blockers. Especially for the readers of "Popular about Health" I will present this tool for consideration.

Components of the tool and form of release

The pharmaceutical product is represented by several tablets. Some of them are white, round, biconvex, you can see a dividing cruciform line and a double bevel. On one side dosage form there is an engraving in the form of "E435". Active substance presented with metoprolol tartrate at a dosage of 25 mg.

Among the excipients in the composition of Egilok, microcrystalline cellulose can be noted, povidone K90 is added, magnesium stearate, sodium carboxymethyl starch, and anhydrous silicon dioxide are present. This medicine is sold in blister packs of 20, in addition, in tinted glass jars, where there are 60 tablet forms.

In other tablets, the active substance is presented in a dose of 50 mg, the medicine is round, there is an engraving in the form of "E434". Auxiliary substances are similar to those presented above. The product is sold in blisters of 15 pieces, as well as in jars of 60 pieces of tinted glass.

Other pills too white color biconvex with a chamfer, you can see the engraving in the form of "E432". The active substance is metaprolol in the amount of 100 mg. The drug is sold only in glass jars of 30 and 60 pieces, the container is packed in a cardboard box. You can buy this product with a prescription. Its shelf life is 5 years.

Action Egilok

The drug belongs to the group of beta-adrenergic blockers. Metoprolol reduces the activity of the sympathetic system directly on the heart muscle, helps to reduce heart rate, reduces heart contractility, and also reduces blood pressure.

Due to the active substance, there is a decrease in myocardial oxygen demand. In myocardial infarction, this medication helps to reduce the mortality rate, and also reduces the risk sudden death. The active substance of the drug is rapidly absorbed from the gastrointestinal tract. Approximately 2 hours after taking the tablets inside, the maximum concentration of this medication is noted in the blood plasma.

Bioavailability does not exceed 70%. The half-life is on average three and a half hours. Approximately 95% of the drug is excreted in the urine.

Indications for use

In Egilok's testimony, his instructions for use included the following cases:

At arterial hypertension;
An effective medication for functional disorder activity of the heart when the patient has tachycardia;
Prescribe a drug to prevent migraine attacks;
Apply means at an ischemic heart disease;
Prescribe medications for heart rhythm disturbances.

In addition, the drug Egilok is used for diagnosed hyperthyroidism.

Contraindications for use

In the contraindications of Egilok, the annotation introduced a ban on the use in such situations:

With cardiogenic shock;
At sinus bradycardia;
Do not use under 18 years of age;
When detecting sinoatrial blockade;
With severe asthma;
Not assigned with intravenous administration verapamil;
With pheochromocytoma;
With hypersensitivity to the drug.

With caution, Egilok is prescribed in the following cases: diabetes mellitus, lactation period, declared depression, pregnancy, metabolic acidosis, in addition, myasthenia gravis, as well as elderly age.

Application of Egilok and dosage

Tablets are taken orally, regardless of the meal. The medicine can be broken in half if necessary. Maximum daily dosage of this medication should not exceed 200 mg. On average, with arterial hypertension, the dosage varies from 25 to 50 mg, if necessary, the doctor can increase the amount of the remedy. As maintenance therapy after a heart attack, from 100 to 200 mg per day is prescribed, the amount can be divided into 2 doses.

Side effects

In general, the drug is well tolerated by the patient, however, some side effects Egilok. Among them: fatigue, dizziness is characteristic, there may be increased excitability, anxiety joins, convulsions are observed, nightmares, depressed mood, and bradycardia are not excluded, in addition, orthostatic hypotension.

Other negative manifestations may be cold lower extremities, cardiogenic shock is not excluded, shortness of breath, especially with physical effort, is observed, rhinitis is observed, there may be nausea, liquid stool, urticaria, photosensitivity is fixed, conjunctivitis joins, and sexual dysfunction is also noted.

In addition, the patient may register increased sweating, in some situations, alopecia is recorded, there may be an exacerbation of psoriasis, in addition, taste sensations, joins arthralgia, laboratory thrombocytopenia, ringing in the ears, characterized by an increase in body weight. If such changes are recorded, it is necessary to consult with the treating specialist.

drug overdose

With an overdose of Egilok may develop the following symptoms: cardiogenic shock, a pronounced decrease in blood pressure, sinus bradycardia is recorded, heart failure, asystole, nausea are characteristic, in addition, loss of consciousness may be noted, up to coma. In this situation, the Patient should be provided with comprehensive medical care.

special instructions

When prescribing Egilok, it is important to regularly monitor the patient's blood pressure, as well as monitor the heart rate.

What to replace?

Metoprolol, metocard, metoprolol organics are analogues of Egilok.

Conclusion

You can use Egilok tablets as directed and under the guidance of an experienced cardiologist.

Antihypertensive drug is the drug "Egilok". What are these pills for? The drug has antiarrhythmic and antianginal properties. Tablets "Egilok" instructions for use suggests drinking with high blood pressure, migraine, angina pectoris.

Therapeutic properties

The medicine "Egilok", from which it helps to normalize pressure, is an effective beta-blocker. The drug creates an antianginal, antiarrhythmic, hypotensive effect. Active ingredient reduces arousal nervous system, quickly reduces the pressure and heart rate. Due to the smooth decrease in vascular resistance, a long-term hypotensive effect is observed.

Prolonged use of the drug in hypertension causes a decrease in the weight of the left ventricle of the heart. Doctors indicate that the drug reduces mortality among men with medium degree high blood pressure. The drug "Egilok", from which angina attacks occur less often, reduces the need for myocardium in oxygen. With its systematic use, the amount of cholesterol in the blood decreases.

Composition and form of release

Produced in the form of white tablets. The active element of the drug "Egilok", from which these tablets are taken for violations of the heart, is metoprolol tartrate. Its amount reaches 25, 50 or 100 mg. A variety of "Egilok Retard" has a similar active ingredient in the amount of 50 or 100 mg. Auxiliary components cellulose, silicon dioxide, magnesium stearate and other components act.

Tablets "Egilok" 25, 50, 100 mg contain a dividing line on one side, and a numerical engraving on the back. The form "Egilok C" includes metoprolol succinate as an active element in the amount of 25-200 mg.

Indications for the use of the drug "Egilok"

What are these pills for? The tool is prescribed for:

• increased rates blood pressure;
• for the prevention of migraine attacks;
• angina;
• violations of the heart;
• tachycardia;
• heart attack;
• atrial fibrillation;
• bradycardia and other cardiac arrhythmias.

Contraindications

Tablets "Egilok" instructions for use and doctors prohibit when:

• bradycardia;
• decompensation heart failure;
• during lactation;
• cardiogenic shock;
• hypersensitivity to the components of the drug "Egilok", from which these tablets can cause allergic reactions;
• sinoatrial and atrioventricular blockade of 2-3 degrees;
• pronounced reduced pressure;
• angiospastic angina.

Caution while taking the medication must be observed in children under 18 years of age and women during pregnancy. Physician supervision is required when prescribing tablets to patients with bronchial asthma, psoriasis, diabetes, myasthenia gravis, kidney or liver failure, thyrotoxicosis, metabolic acidosis, depression.

Medicine "Egilok": instructions for use

Tablets are taken orally with a sufficient volume of liquid, regardless of the meal. The dosage is determined by the specialist depending on the indications and individual features sick. The daily volume of the drug should not exceed 200 mg. Tablets are drunk 2 times a day, dividing daily dose in half. Instructions for use "Egilok Retard" is similar.

Daily dosage for diseases

For the secondary prevention of a heart attack, take 200 mg. For the treatment of heart failure, 25 mg per day is prescribed. With hyperthyroidism, arrhythmia, tachycardia, the use of 50-200 mg is indicated. For angina pectoris, the dose is 50 mg per day. To prevent migraine attacks, you need to drink 100-200 mg per day.

Tablets "Egilok C" instruction prescribes to use 1 time per day, in the morning.

Side effect

The drug "Egilok", instructions and reviews indicate this, can cause negative reactions from various systems organism. Adverse reactions include:

• palpitations, weakness, abdominal pain;
• nasal congestion, decreased libido;
• sinus bradycardia, fatigue;
• dry mouth, itchy skin;
• orthostatic hypotension, headache;
• constipation, shortness of breath; hives, weight gain;
• cardialgia, depression, nausea, vomiting;
• rash, exacerbation of psoriasis, arrhythmia;
• confusion, change in taste;
• leukopenia, increased sweating;
• back pain, asthenic syndrome;
• agranulocytosis, photodermatosis, hypoglycemia;
• hyperemia of the skin, memory impairment.

Analogues

The following analogues of Egilok have a similar effect on the body:

1. "Metoprolol".
2. "Lidalok".
3. "Metolol".
4. "Concor".
5. "Metocard".
6. "Betalok".
7. "Emsok".
8. "Corvitol".

"Concor" or "Egilok" - which is better?

Doctors answer in the following way. Analogue "Concor" causes less adverse reactions, its use is more appropriate with a low pulse. The drug "Egilok" 100 mg and in other dosages is more strong remedy how it differs from Concor.

Price

In Moscow, St. Petersburg, you can buy "Egilok" 50 mg at a price of 137 rubles. In Ukraine, the medicine costs 55 hryvnias. In Minsk, it is offered for 6-13 bel. rubles. The price in Kazakhstan reaches 1245 tenge (Egilok 25 mg No. 60 tablets (pcs.) EGIS Pharmaceuticals, Ltd. (Hungary)).

Egilok refers to complex preparations that regulates heart rate and normalizes blood pressure. It is an indispensable medicine for people old age and all those who suffer from cardiovascular problems. The range of indications for the use of Egilok is very wide.

The drug Egilok - the use is justified

The use of the drug Egilok became widespread only in last years, until then, physicians preferred to use individual preparations for the treatment of each of the diseases in which Egilok is effective. This approach is fully justified, but usually, heart failure, vascular problems, high blood pressure and other diseases caused by the frequency of heart systoles are observed simultaneously. It is much easier to take one tablet of Egilok than a handful of medicines!

The drug belongs to beta-blockers, that is, it reduces the action of adrenaline, due to which the number of systolic contractions of the heart decreases during an attack. The main thing active substance- metoprolol. The effect of taking the drug occurs after 20 minutes, becomes maximum after 3-4 hours and completely disappears within 6 hours. It is excreted from the body mainly by the kidneys. The use of Egilok is shown to all elderly people without exception, since age-related changes the work of the heart makes no exception.

In general, Egilok tablets have the following indications for use:

• tachycardia;
• arrhythmias of various kinds;
• thyrotoxicosis;
• hyperthyroidism;
• primary and secondary hypertension;
• previous myocardial infarction and clearly undefined heart disease;
• migraine;
• elevated level cholesterol in the blood.

The drug Egilok and features of indications for use

Doctors recommend taking Egilok with food, this allows you to increase its bioavailability by 40-60 percent. If this is not possible, you can use the drug on an empty stomach. The medicine must be taken with a sufficient amount clean water otherwise the expiration date will change.

During treatment, you should pay attention to other drugs that you use, together with Egilok, they can give an unpredictable effect. For example, the simultaneous administration of Verapomil and taking Egilok can provoke cardiac arrest. Nifedipine will cause very strong and a sharp decline blood pressure. In combination with ethanol and alcohol-containing agents, Egilok has a depressant effect on the central nervous system. This drug enhances the effect of muscle relaxants, anticoagulants and some other drugs.

Since Egilok can cause a strong reduction in the number of heart systoles, as well as too intensive decline blood pressure, these indicators should be constantly monitored while taking the drug. You should be alerted by a pulse below 60 beats per minute - this is a good reason to immediately seek medical help.

Contraindications to the use of Egilok

The medicine should not be used by persons under the age of 18. With caution, the drug is prescribed to pregnant and lactating mothers. Egilok is also contraindicated during acute heart attack, heart attack. Here short list factors limiting the use of the drug.

Egilok is a remedy for
treatment of diseases of the cardiovascular system.

pharmachologic effect

Egilok, according to the instructions, refers to beta1-adrenergic blocking agents.

The main active ingredient is metoprolol. It has antianginal, antiarrhythmic, pressure-lowering effects. By blocking beta1-adrenergic receptors, Egilok reduces the excitatory effect of the sympathetic nervous system on the heart muscle, quickly reduces heart rate and blood pressure. The hypotensive effect of the drug is long-lasting, as peripheral vascular resistance decreases gradually.

On the background long-term use Egilok with high blood pressure significantly reduces the mass of the left ventricle, it relaxes better in the diastolic phase. According to reviews, Egilok is able to reduce mortality from cardiovascular pathology in males with a moderate increase in blood pressure.

Like analogues, Egilok reduces the heart's need for oxygen due to a decrease in pressure and heart rate. Due to this, diastole is lengthened - the time during which the heart rests, which improves its blood supply and the absorption of oxygen from the blood. This action reduces the frequency of angina attacks, and against the background of asymptomatic episodes of ischemia the physical state and the patient's quality of life is greatly improved.

The use of Egilok reduces the frequency of ventricular heart contractions in atrial fibrillation, ventricular extrasystole and supraventricular tachycardia.

Compared with non-selective beta-blockers of Egilok's analogues, it has less pronounced vasoconstrictor and bronchial properties, and it also has less effect on carbohydrate metabolism.

Against the background of taking the drug for several years, blood cholesterol is significantly reduced.

Release form Egilok

Egilok is produced in tablets of 25, 50 and 100 mg.

Indications for Egilok

The drug is used to treat angina pectoris, myocardial infarction, arterial hypertension, including in elderly patients, rhythm disturbances, in complex treatment migraine.

Contraindications

According to the instructions, Egilok can not be used in case of atrioventricular blockade of 2 and 3 degrees, weaknesses sinus node, lowering blood pressure below 90-100 mm Hg. Art., with sinus bradycardia with a heart rate below 50-60 beats per minute.

Hypersensitivity to the components of the drug is also a contraindication.

Instructions for use Egilok

The drug in tablets is taken regardless of food, dose selection is strictly individual and should be carried out gradually. More than 200 mg / day Egilok can not be taken. To achieve the effect, regular intake of the drug is important.

To lower blood pressure, start with a dose of 25-50 mg 2 times a day (morning, evening), if necessary, increasing the dose.

For the treatment of angina pectoris
take 25-50 mg 2-3 times a day, if the effect is insufficient, the dose is increased to 200 mg / day or another drug is added to the treatment regimen. It is advisable to maintain a heart rate of 55-60 beats / min at rest and no more than 110 beats / min during exercise while taking the medication.

As maintenance therapy after myocardial infarction, 100-200 mg / day is prescribed in 2 divided doses.

With cardiac arrhythmias, the initial dose is 25-50 mg 2-3 times a day, in case of insufficient effectiveness, increase it to 200 mg / day or add another antiarrhythmic agent to the treatment regimen.

If there are indications for Egilok in the treatment of migraine attacks, its dose in this case is 100 mg / day in 2 divided doses.

At concomitant pathology kidney and liver, as well as in elderly patients, dose adjustment of Egilok is not required.

When used by a patient contact lenses the patient should be aware of possible appearance discomfort due to a decrease in the production of tear fluid during treatment with this agent.

If planned surgery against the background of taking Egilok, it is necessary to warn the anesthetist about this so that he can choose adequate means for anesthesia with a minimal inotropic effect. It is not required to cancel the drug.

It is necessary to complete the treatment with the drug gradually, reducing the dose every 2 weeks. Abrupt withdrawal of the drug may worsen the patient's condition.

Side effects

According to reviews, Egilok is sometimes able to cause headache, fatigue, depression, insomnia, dizziness, decreased concentration, decreased heart rate, shortness of breath, bronchospasm, rhinitis, nausea, diarrhea, vomiting, abdominal pain, increased sweating, allergic reactions.

Sincerely,