The main disadvantage of our teeth is that they grow only from two groups of rudiments formed during intrauterine development. Primary crowns appear from the first group, and permanent crowns from the second.
If a permanent tooth is lost, it can only be replaced with an artificial one, which cannot fully perform natural functions, and even in this case the procedure is not recommended for everyone. This gave scientists the idea of growing human teeth.
To date, after large quantity Through research and experimentation, it was still possible to grow a tooth.
From history
The first developments on this project began in England in 2002. For their experiment, a group of scientists used piglet crowns six months of age and rats.
The research team was led by Pamela Yelick. The piglets had confiscated immature cells of dental tissue, which placed into enzymes.
Innovations in dentistry
After their formation, cells transferred onto a polymer plate, which gradually decomposed during cell development. Fully formed primordia implanted in rats.
Exactly 3 months later, the rats had new crowns with defective dentin, a complete absence of enamel and an unformed root.
Based on previous research, the experiment was continued by scientists from the city University of Sciences Tokyo in 2007. Takashi Tsuji and his colleagues were able to grow new teeth and successfully implant them into young mice.
The newly grown organs fully performed their functions. They had formed dental tissues and lacked the root part.
himself best result the same group achieved, but already in 2009. For their research, Tokyo scientists used a different technology than what was used previously. To form the rudiment, they took mouse cells, responsible for the development and growth of teeth, and stimulated their growth in a collagen environment.
After which hooked up rudiments in place of the removed crowns. In their place, normal teeth grew with a complete crown and root part. During growth in the pulp there was neurovascular bundle formed, responsible for further nutrition of dental tissue.
Genes
Scientists from the University of Zurich began identifying the gene responsible for tooth growth. They discovered that these processes are responsible Jagged2 gene and a section of chromosome with the name Notch. It was found that in the absence of activity of this gene, Notch begins to work with pronounced errors.
Based on the data obtained, scientists continued their research and isolated the gene responsible for formation of the correct position of the crown – Osr2. When it was deactivated, deformation of the dentition was detected with the growth of crowns beyond its limits, as well as the formation of a cleft palate.
Growing new teeth in humans artificially
For initiation of primordia formation gene answers Msx1. The experiment showed that in the presence of this gene and in the absence of others listed here above, single organs still developed. But when they were activated and Msx1 was turned off, no development of primordia occurred.
Based on the data obtained, scientists came to the conclusion that without the Msx1 gene, growing teeth is impossible.
Rudiments from stem cells
Professor Mitsiadis, after a detailed study of the relationship between gene activity and rudiment development, revealed that genes those responsible for their formation take an active part in stem cell production dental tissues.
Based on this, some scientists began to believe that for abnormalities of a number of teeth caused by genetic factors, stem cells could be used as a restoration therapy.
These cells are the only ones that have the ability to restore damaged cells of the body, replacing them through their division.
To form a crown stem cell planted in an empty alveolar socket and left alone. Over time, it forms a new germ and then a tooth.
At the same time, the growth process is accompanied by the same sensations as in childhood. The shape of the crown and root does not differ from real teeth.
The only caveat of this method is that with age stem cell count hopelessly diminishing. If at the age of up to 25 years one can find one such cell per 100 thousand, then at 50 years there is 1 cell per 500 thousand.
Besides, material collection process for cell isolation very painful. Therefore on at the moment Scientists are more focused on developing methods that would allow material to be collected more efficiently and less painfully.
Animal experiments
Photo: growing a real living tooth
The stem cell complex was infused into mice. In order to be able to monitor the process in detail, green fluorescent protein, which is safe for the mice, was added to the cells.
This experiment ended with the appearance of a new tooth. The studies carried out showed the following:
- grown crown and root according to their shape no different from a real tooth;
- the anatomical structure included exactly the same elements: pulp, neurovascular bundle, dentin, enamel;
- dental tissues had high strength, allowing you to fully perform all functions;
- the size of the crown part was slightly smaller than standard indicators.
This video talks about the methods by which scientists managed to achieve their first results:
Methods
In theory for growing human teeth There are 2 methods: internal and external.
Interior
This method involves growing directly in the human oral cavity. Internal method was developed by a Ukrainian scientist and consists of introducing stem cells into empty alveolar sockets. To do this, he suggests using cells isolated from fallen milk crowns.
They are necessary inject under the mucous membrane. Around 3 or 4 months, active cell proliferation and formation of the rudiment occurs. At the end of this period, a new tooth appears.
At the moment, this method is the simplest, but long-term. Moreover, he never received detailed research due to lack of funds for financing.
Outer
The external method involves the formation of a tooth outside the mouth and then its further implementation into the alveolar bone socket for engraftment. To do this, they suggest using two growing methods:
- In organic culture. For this purpose, cells of a primitive type are used: mesenchymal and epithelial. The combination of these cells is placed in a collagen scaffold to form the bud.
Then the germ is transferred to an organic culture and after 2 weeks a tooth with enamel, dentin, blood vessels and pulp is obtained. These periods are typical for growing a mouse crown, the size of which was only 1.3 mm.
- In a special test tube. In this case, exactly the same cells and the principle of embryo formation are used, but later it is placed not in organic matter, but in a capsule.
In order to ensure the growth of the crown, the capsule is implanted into the liver of the mouse. The timing of tooth formation in this case is no different from the first method.
Humanity will soon be able to grow new teeth on its own.
Side effects
Despite the success of all recent research, these developments are still not being actively developed. This is primarily due to the side effects that may accompany this procedure.
When replanting a tooth or growing it it is impossible to control the growth rate each of its elements. In a normal process, the neurovascular bundle should develop at the same rate as dentin.
Otherwise, you can initially get pathological crown, which can affect both oral health and any body systems.
There is also a problem with the body's immune response on the implanted cells. Perceiving them as foreign bodies, the immune system will reject them in every possible way.
To reduce the risk similar situation at a minimum, the patient will have to take serious dosages of immunosuppressants, which can completely deprive him of immunity for life.
The main disadvantage of the ongoing developments is the lack of a combined approach that would take into account all the nuances of this procedure and its consequences.
Criticism
Most scientists, even when studying already confirmed positive data, are of the opinion that these are useless, meaningless developments.
In their opinion, a single tooth growing in a mouse does not prove that stem cells will always behave as predicted.
In addition, these manipulations are associated with such number of problems and questions, which no scientist can solve yet.
Also, many are confused by the effectiveness of engraftment of an artificially obtained embryo. Not long ago, doctors attempted implantation patient's own teeth from one part of the jaw arch to another.
This technique has shown that low survival rate, which has not found wide application in dentistry. Judging by unsuccessful result With this method, a grown tooth that differs little from your own may also simply not take root.
Many people are also confused by the fact that when replanting the germ, it is difficult to predict the type of tooth that will grow. For example, a molar or incisor will erupt in place of a fang.
When will the service be available?
Inspired positive result, Tokyo scientists began to further study this area. Today, they are successfully working on the differentiation of the created rudiments, which would allow precise positioning of the alveolar ridge section with the crown number.
New Dentistry of the Future: Growing Teeth
The scale and pace of research allowed scientists to assume that closer to 2030 The method of growing human teeth will become widespread and will gradually replace prosthetics and implantation.
Price
According to scientists, this technique will have the same cost as standard prosthetics using implantation, since its cost is not so high.
But if we take into account market marketing, then even with widespread distribution there is still at least 10 years after its appearance in clinics this service will be the most expensive of all dental work.
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2 Comments
Kate
October 8, 2016 at 01:45 pmDouble feelings after reading. It is not entirely clear why it is necessary to grow a tooth, which, moreover, is not known what kind it will grow. Prosthetics, in my opinion, is now at a fairly advanced level. high level. The materials used in dentures sometimes match the quality of your own teeth. It’s not clear whether it’s worth bothering so much and risking your health.
Lina
October 19, 2016 at 4:16 amDental specialists apparently still need to work hard on the procedure for growing teeth. While it is not yet completely harmless to humans and does more harm than good. Although it's not a bad idea. In general, there are now enough methods that allow you to renew your teeth. For example, extensions, or prosthetics. The main thing is to find a good specialist.
Dasha
November 7, 2016 at 0:34Everything is developing and science does not stand still, I think this is good, let scientists develop and research this technique! Prosthetics is of course an option, but for now, I think many will opt for a more natural and authentic tooth. When all risks are minimized, and the issue is sufficiently studied, the procedure will most likely become simple and familiar to all of us, as for example professional cleaning teeth at the dentist or whitening (this won’t surprise anyone).
Sasha
January 17, 2017 at 9:50 amI agree with Dasha. It is not clear why there is not enough funding for scientific developments that help human health! What are people thinking about!? In my opinion, it is in scientific developments that a happy, healthy future lies. And the sooner widespread implementation begins, the better. Previously, potatoes were considered an inedible plant and only its flowers were used for decoration. Growing teeth, in my opinion, is simply brilliant. Why can't you try shark cells?!)
Svetlana
April 4, 2017 at 3:59 amProsthetics are now developed at a high level, this is a fact, but no super modern dentures can replace natural teeth! It's good that science doesn't stand still. 20 years ago they knew nothing about the same implants, but now they are used everywhere. The idea of growing teeth is simply great! I hope that by my old age they will have time to introduce this technology and will be able to do without removable jaws in the cup.
Alexander
September 23, 2017 at 6:08 amOkay, what is being done now and when will such technologies be available to the average person?
As for why such technologies are needed, an implant approaches a natural tooth in terms of aesthetic and functional properties, surpassing bridges and false jaws. This is already progress and a reason to develop and implement new technologies. But a natural tooth allows you not only to chew, but also to receive information, fully experiencing food. Or all kinds of dirolls with orbits :)))
As for growing teeth and implantation, everyone has and will have their own niches. For those who have chronic disorder in their body, artificial structures have their advantages: they put you “above the situation.” And for those whose teeth have been lost due to injury or lack of care, those newly grown teeth will come in handy.
On March 6, many countries celebrate International Dentist Day. The date was not chosen by chance. It was on this day, more than 100 years ago, that the first prototype of the well-known drill was created. Today, the capabilities of dentists have expanded significantly. And what seemed fantastic is reality today. MedAboutMe joins in the congratulations and will talk about new dental opportunities in the field of restoring lost teeth and enamel. Is it possible today to grow a “tooth in a test tube”?
Dentists joke
One of the most famous dental jokes is: “Nature only gave us two sets of free teeth. For the third one, you will have to pay! And, if now you have to shell out money for plastic, ceramics and cold “metal”, then new scientific achievements will soon make it possible to get natural teeth for money.
Dentists and patients have always been interested in the possibility of regenerating enamel without using Greenwood's most famous invention - a drill, that is, replacing lost teeth with new ones. And if previously this was impossible, today, like science fiction, it is coming to life.
Does it mean that soon human teeth, just like rodents, will constantly grow, the enamel will be restored, and the ones that fall out can be replaced with your own, grown in a test tube?
“32 heroes”: why can’t there be more teeth?
Each person is given 2 sets of teeth during his life: 20 milk teeth and 28-32 permanent teeth. This number of teeth was formed in the process of evolution, and nature considered it sufficient for chewing food.
But many still have vestigial third molars, better known as wisdom teeth. There are cases when “lucky” patients were the owners of fourth molars, and in total there were 33-36 teeth in the oral cavity.
The presence of third molars is not necessary; they are no longer involved in the process of chewing food. And during the evolutionary change in food habits, the emergence heat treatment food, the jaw has become smaller and there is no longer enough space for the full eruption of third molars.
At the same time, it is increasingly possible to see patients whose baby teeth have not been replaced at all and fully perform the functions of permanent ones.
According to many dentists, perhaps in a few centuries, the need to change teeth will disappear altogether. The timing of the eruption of baby teeth will shift, and the concept of “changeable bite” will cease to exist altogether.
Natalya Maykova, owner of 2 milk teeth, Arkhangelsk
I learned that I have a unique feature (not that unique, but rare), when I was 19 years old. My wisdom tooth hurt very badly, and I went to the dentist. Knowing that dentists are in no hurry to save “eights”, because these teeth usually grow poorly and deteriorate very quickly, I was already prepared to remove the tooth, which, by the way, had been filled earlier. But the dentist told me that I needed to remove the old filling and “clean” the canals again. After all, losing a second molar at such an age is very disappointing. I was surprised and taken aback. How come it’s a second molar and not a third? And then I just counted my teeth. Exactly! There are 7 teeth on each side, but it turned out that out of 3 molars I have - 1 milk one, on each side! What a surprise! It turns out that an adult has milk teeth. In my case, these are “fours” on lower jaw. They took a picture of me, and I was very upset when the doctor did not see any rudiments in the jaw permanent teeth. This means that if baby teeth fall out, new ones will not grow! We must take care of them. But now 10 years have passed, and my baby teeth still sit firmly in the jaw, and have not yet been susceptible to caries. My peculiarity does not interfere with my life at all, and those around me do not suspect anything.
Teeth like a shark: lucky or not?
It is known that sharks have teeth that grow in several rows, and their total number is close to 250. It is sharks that are the envy of patients who have lost one or more teeth. But is it worth it? Sometimes, supernumerary teeth may appear in the oral cavity of a person, growing in several rows. But this fact, for the most part, is not a reason for pride and envy.
When the germs of teeth are formed, even during pregnancy, disruptions may occur. And when permanent teeth erupt, extra ones appear: instead of the required 4 premolars - 8, instead of 4 incisors - 6 or more. Extra teeth, that is, in addition to the main set, are called supernumerary.
Their appearance cannot be called rare. And until recently, the exact reasons for their formation were not known. But in June 2017, the scientific world was presented the real reason formation of extra teeth.
Scientists from the University of Texas, USA, discovered that when the FAM20B gene was deleted, supernumerary teeth developed. This gene itself is responsible for the formation of cartilage tissue. But in experimental mice, “turning it off” led to increased enamel mineralization and the growth of extra teeth.
Leading researcher of the study, Dr. Xiofang Wang, notes: “Having such teeth is not beneficial for dental health and occlusion. But understanding the process of their formation is important. After all, this knowledge can be used to regenerate teeth and, of course, to prevent the appearance of supernumerary teeth.” At the moment, scientists have received a large grant and continue their research.
In 2014, The Times of India published an article about a group of surgeons who removed 80 teeth from the jaw of a 7-year-old boy! A small patient asked for help for a completely different reason. After the examination, odontoma was discovered - a tumor that occurs due to disruption of the development and formation of dental tissue. The operation itself lasted about 4 hours.
Leading surgeon Dr. Ankit Khasgiwala noted that in this age group similar tumors are rarely diagnosed, and if the patient, whose name remained secret, sought help a few years later, there could be about 200 supernumerary teeth. There is a known case in which more than 230 teeth were removed from a 17-year-old teenager from India.
Young man 32 years old from Saudi Arabia appealed to an ENT specialist with complaints of constant nasal congestion and bleeding that occurred for no reason. During the examination, an erupted supernumerary tooth was discovered in the nasal cavity. This unique case became known in August 2014.
Unique cases
There are stories on the Internet about unique cases: “I grew another tooth,” “After the tooth was removed, I used unique means, and, oh, miracle, I grew a new tooth!” What is this? Imagination of the authors, unique cases or deception?
It’s worth starting with the fact that not a single product sold on the Internet or in pharmacies, be it “ magic pills, powder or gel" cannot stimulate the growth of teeth and even enamel. If, during intrauterine development, the formation of 28 rudiments of permanent teeth occurs, that is how many of them will erupt. The only exception is wisdom teeth, the formation of the rudiments of which begins at the age of 5-9 years. And, even if there are rudiments, their appearance in the oral cavity is not necessary.
If, due to some circumstances, there was a failure in this process, and instead of 28 rudiments, 29-36 appeared, then there may be “surprises” in the future. Often, supernumerary teeth are impacted, that is, they are deeply “settled” in the jaw and are in the wrong position, pressed down by the root of the “twin tooth.”
If permanent tooth was lost or removed - this process stimulates eruption impacted tooth. As a result, one fine morning, the stunned patient notices the eruption of another tooth in place of the extracted tooth. This is how legends are born.
Knocked out a tooth doesn't mean forever
“Spolt is a rant” is one of the most famous demotivators on the Internet. And, usually, these phrases belong to hockey players. Indeed, a coward does not play hockey. Often, athletes are let down by “defense” - and injuries occur, and knocked out teeth are no exception.
Dentists assure: a completely knocked out tooth (complete dislocation) does not indicate its irreversible loss, and with the correct and clear algorithm of actions it can be safely returned to its place. This operation is called reimplantation. It is possible due to the ability of periodontal tissue to recover and form new bonds. But to succeed, you need to act quickly.
After the injury, and if the tooth was knocked out completely, provided that the root of the tooth was not damaged and remained intact, the patient has 72 hours to contact a dental surgeon and have the operation performed. And the sooner it is carried out, the better the future forecasts.
After a tooth has been completely dislocated, it must be carefully examined: assess the integrity of the root, the presence of cracks, and place it in a nutrient medium. It is reliably known that the most optimal storage medium is the patient’s own saliva or saline solution.
There are conflicting opinions about other nutritional media such as water and milk. Most authors agree that these environments negatively affect the condition of the knocked-out tooth and the subsequent outcome of reimplantation surgery. But if there is no other option at hand, you can use them.
Exactly from proper storage tooth, the choice of nutrient medium and timely contact with the dentist will depend on the success of the operation.
Already in the dentist's office, under the influence local anesthesia, the hole is processed and the tooth is implanted in its place. To fix it in place, dentists use the splinting method for a period of 3 weeks or more. At this time, the doctor monitors the healing processes and makes a prognosis for further treatment tactics.
Subsequently, the tooth must undergo endodontic treatment - removal of the tooth pulp with filling of the root canals.
Growing a “tooth in a test tube”: expectation and reality
The possibility of regenerating one's own teeth has always worried dentists. And, if earlier attempts to grow “teeth in vitro” were unsuccessful, today such an opportunity has arisen. The mechanism that made it possible to achieve the results is simple, like everything ingenious - a full-fledged organ can be formed from one cell.
Russian scientists extracted cells from a tooth germ from a donor mouse and transplanted them into another animal. As a result, it was possible to grow a full-fledged tooth in 2 weeks, while the mouse did not experience any discomfort and suffering.
Igor Malyshev, head of the Department of Pathophysiology at Moscow State Medical University, notes: “Teeth themselves are an inexhaustible source of stem cells, and perhaps soon there will be a need to create appropriate storage banks. In the future, if a tooth is lost, patients will be able to restore the defects with their own biological material. And dentists will have a unique opportunity to regenerate lost teeth.”
Fact!
MedAboutMe reminds that the source of stem cells can be the dental pulp. Recent studies have shown that the pulp of wisdom teeth contains cells that can become the precursors of most cells in the body. In addition, each tooth has a so-called growth zone - by extracting cells from this area, modern dentists can already grow full-fledged teeth.
Research by scientists is also aimed at the possibility of restoring teeth using 3D printing technologies. At this time, the data obtained is insufficient to make such statements. But, as scientists predict, in a few years this industry will change all ideas about the process of prosthetics and implantation.
Russian scientists suggest that in just a few decades, reimplantation of a “test tube tooth” will become as common a procedure in the dentist’s office as prosthetics.
With the development of new prosthetic technologies, 3D printing is being widely introduced into dentistry. Today, “printing” part of a tooth - a crown or inlay to restore lost enamel and dentin - is a reality. But, as they say, there is no limit to perfection.
Scientists from the Netherlands have created an antibacterial polymer from which teeth can be “printed” to improve the microflora of the oral cavity. This polymer is planned to be used to create crowns and subsequent prosthetics on implants.
The uniqueness of the polymer lies in the inclusion of quaternary ammonium salts in its composition, which can destroy bacterial biofilms. According to study author Andreas Hermann, “the material destroys bacteria, but is absolutely safe for cells human body».
Data were provided to support his words: printed artificial teeth made of polymer were placed in a mixture of saliva and bacteria that cause caries. After 6 days, it was found that 99% of the environment had died dangerous bacteria. And in the control samples, where the polymer was not used, there were less than 1% dead bacteria.
Currently, scientists are working on introducing ammonium salts into oral hygiene products and assessing how durable the material is and whether it can fully withstand the chewing load.
As scientists from the USA assure, this discovery is very important and will significantly reduce the risk of implantation complications and the formation of peri-implantitis. In the United States, treating bacterial damage to installed implants costs patients and dentists millions of dollars.
Is it possible to restore enamel?
IN lately there is a general fashion for miracle remedies that save you from all troubles and misfortunes: a remedy that gets rid of excess weight in 3 days, an anti-wrinkle cream that restores youth in a few seconds, and drugs that restore enamel and treat caries, and you need to rush to the dentist for an appointment not at all necessary.
To prove the properties of the “miracle remedies”, photos are given: “before” and “after”. Moreover, the picture is striking: if previously the teeth were crooked, yellow and affected by caries, then after using the products they meet all standards Hollywood smile. As dentists sarcastically note, such products are truly “unique”: not only do they restore enamel and treat caries, but they also change the shape of teeth and correct the bite. Their real effectiveness is nothing more than a marketing ploy and ordinary deception.
Meanwhile, there are truly effective remedies that will help restore enamel, but from which you should not expect fantastic results. Remineralizing toothpastes, gels and varnishes used in the dentist's chair can restore the enamel structure and treat caries. But! The products will be effective only for caries in the spot stage, when pathological process develops within the surface layer of enamel, and nothing else! In addition, such pastes do not affect the activity of bacteria, therefore, even if this outbreak was eliminated, there is no guarantee that it will not reappear.
In this case, it is possible to restore enamel by replenishing lost minerals from the crystal lattice and increasing resistance to aggressive agents in the oral cavity. Typically, such products are used in dentist chairs and are characterized by increased concentration active substances. Mistakes in their use can cause more harm than good.
Calcium hydroxyapatite is the main substance of enamel. And created in laboratory conditions the mineral has long been successfully used in dentistry to create medicinal toothpastes for sensitive teeth, or in the dentist's chair to solve various problems. At the moment, the technology for its production is complex and requires large financial costs.
A team of chemists from Nizhny Novgorod state university named after N.I. Lobachevsky, a new one-stage technology for the production of artificial nanohydroskyapatite was developed. According to the scientists' plans, the material is planned to be used not only to restore lost enamel, but also in the manufacture of implants and the elimination of skin defects.
The main advantage of the created mineral is improved biocompatibility and the ability to control the biological and mechanical properties of the material. It is planned that it will gain popularity in the field of prosthetics, restorative dentistry and implantology.
This article collects evidence of the regeneration of new teeth that has been leaked to the media, and also provides a general description of the techniques that various authors offer in order to restore extracted and diseased teeth.
Here are a few brief headlines from materials that document this phenomenon.
“...Mikhail, yesterday I watched a report on TV about a grandmother who, at the age of 70, discovered that her teeth began to change for the third time in her life...”
“...In a neighboring village, a healer teaches people how to build up enamel on damaged teeth by rinsing their mouth with a propolis solution and using a mental image.”
“...The doctors of the Drozhzhanovsky district hospital could not believe their eyes when their ward Maria Efimovna Vasilyeva opened her mouth wide. Wow, a 104-year-old resident of the village of Chuvashskoe Drozhzhanoe has... started to grow teeth again!”
“...Daria Andreeva, a 94-year-old resident of Cheboksary, has started cutting new teeth. According to specialists from the Chuvash Republican Dental Clinic, the old woman has already erupted one tooth.”
“...At a resident settlement Sharanglu, Iranian province of East Azerbaijan, has grown new teeth to replace those lost due to old age.”
“...Unexpected happiness befell Marya Andreevna Tsapovalova, who lives at the Rehabilitation Center for Pensioners in Sochi. At the age of one hundred, she suddenly began to grow new teeth!
“...One of them is 128-year-old Iranian Bahram Ismaili. Due to old age, he lost only three teeth, and new ones grew to replace them. Bahram also does not eat meat. Besides, he had never brushed his teeth in his life.
A similar incident happened to the Indian peasant Baldev. He grew new teeth at 110 years old. Baldev - heavy smoker. He complains that he has long been accustomed to holding the pipe with his toothless mouth and now it is inconvenient for him to clamp it with his teeth.”
“...12-year-old French girl Michelle was a little unlucky in life. The fact is that the girl suffers from a rare hereditary disease. Michelle has grown shark teeth that constantly break and grow back. She has much more of them than ordinary people, and they grow in several rows. Michelle recently had 28 teeth pulled. And still she has 31 more of them than she should.”
Quote from an article by Natalia Adnoral:
Miracle one: there may be no caries. A similar phenomenon was observed by Italian dentists who visited several monasteries in Tibet. Of the 150 monks examined, 70% did not have a single diseased tooth, and the rest had extremely limited caries. What is the reason? Partly due to dietary habits. The traditional menu of Tibetan monks includes barley cakes, yak milk butter, Tibetan tea; In summer, turnips, potatoes, carrots, and a little rice are added, sugar and meat are excluded.
What if caries has already damaged your teeth?
Miracle two: tooth decay can be reversed. An example of this is the cases of self-healing caries observed by dentists, when the affected tissues become strong again, and the restored area of the tooth acquires a darker shade. And such cases are by no means isolated. How does this happen? Builder cells detect damage and restore the integrity of the tooth in the same sequence in which it was originally created.
Well, what if caries has won and there is nothing left of the tooth?
Then prosthetics, of course.
Miracle three: new teeth can grow. This is called the “third change of teeth” and is observed in very old people. And although a person does not have the rudiments of the third generation of teeth, there are remnants of “eternally young” tissues that suddenly, for reasons that are not entirely clear, remember their destiny to become teeth and successfully realize their potential. Similar messages are not uncommon lately: a 110-year-old resident Indian state Uttar Pradesh grew two new teeth; a 94-year-old resident of Cheboksary and a 104-year-old woman from Tatarstan began to cut new teeth; As many as six teeth appeared in an 85-year-old Novgorod woman... Of course, one can be skeptical about sensations. If only... not for the latest discoveries of science.
A scientifically proven miracle. A group of scientists from the American Research Center of Texas, led by Dr. McDougal, studied special cells that produce dental tissue (enamel and dentin). The genes responsible for this production are active only during the period of tooth formation, and then turn off. Scientists managed to “turn on” these genes again and grow a full-fledged tooth (for now “in vitro”, outside the body). True, one cannot count on rapid changes in the practice of prosthetics. It will take at least 20 years for the technology of growing your own teeth to become widespread..."
A few more studies reported by the media:
Researchers at Osaka University are preparing to clinical trials in public. According to scientists, this method is much cheaper than prosthetics, ITAR-TASS reports.
The treatment system is based on the effect of genes that activate the growth of fibroblasts. This is the main cellular form of connective tissue.
Its effect was tested on a dog that had previously developed severe form periodontal disease - atrophy of the tissue around the teeth, leading to their loss. Then the affected areas were treated with a substance that included the mentioned genes and agar-agar - an acidic mixture that provides a nutrient medium for cell reproduction. Six weeks later, the dog's fangs erupted. The same effect was observed in a monkey with teeth cut down to the base.
Today, Paul Sharp from King's College in London is engaged in growing teeth; he also heads the most famous company in this area - Odontis - at Guys Hospital in the same London. In addition, the Forsyth Institute in Boston, America, and Queen Mary's College in the English city of Hants are working in this direction. Among our scientists, Poltava geneticist from the Center for Transplantation of Cryopreserved Embryonic, Cellular and Fetoplacental Tissues Alexander Baranovich is working in this direction.
A few quotes:
A revolutionary method of growing teeth has been developed in Ukraine. The author of the idea is Alexander Baranovich, a geneticist at the Poltava Center for Transplantation of Cryopreserved Embryonic, Cellular and Fetoplacental Tissues.
He is working on creating a unique technique with which toothless people can renew their jaw with virtually no prosthetics. To do this, an injection of liquid based on the stem cells of the fallen baby teeth is made into the patient’s gums at the site of the lost tooth. Once in the bone tissue of the jaw, the cells begin to multiply, and in 3-4 months a new tooth grows.
According to the scientist, similar experiments are being carried out in the West. So, English doctor Paul Sharp is close to creating a genetic gel with which a new tooth can be strictly programmed to exactly the shape and size of its fallen predecessor.
A team of researchers from the University of Oregon (USA) after a long search found the gene responsible for the production of tooth enamel, which is so necessary for teeth. It is the inability of enamel to recover that leads to tooth damage in more than 8/10 of the world's population. It is possible that scientists will be able to force the found gene to restore enamel, covering vulnerabilities. Thus, caries and some other dental diseases can be avoided.
Scientists called new type Ctip2 gene - interestingly, it is responsible not only for the production of enamel, but also for some functions of our immunity, the development of the skin and nervous system. Now we can add enamel restoration to this list of responsibilities of this gene.
Japanese scientists from medical university the city of Hokkaido managed to develop a unique technology for dental treatment thanks to the invention of a special chemical composition, which is based on the proteins collagen and phosphorin.
During the experiment, doctors placed a loose protein mass into a tooth of an experimental dog damaged by caries. Just two months later it was recorded full recovery dentin. Dentin is the substance that forms the basis of the tooth.
Japanese scientists intend to begin human trials as soon as possible. short terms, the practical application of the discovery will become possible within five years.
Scientists have managed to create a technology that allows one to grow new teeth in place of lost ones. The miniature system uses ultrasound pulses to stimulate the formation of dental tissue and help heal diseased teeth, reports Eurekalert.
A small wireless device sealed in a casing made of biomaterials will not cause any inconvenience to the patient. It is attached to the oral cavity by any in a convenient way, for example, on “braces” or in a removed crown. Scientists have also developed a sensor that changes the power of the device so that the pulses always reach the roots of the teeth. The researchers hope to present a finished model of the device by next year.
The device is intended for patients with tooth root resorption, which occurs from mechanical or chemical damage. Mechanical damage are caused by wearing corrective braces for a long time. The new device will allow such people to wear “braces” and not worry about anything. It is assumed that among this segment of the population (in North America five million people wear braces), sales of the device will amount to 1.4 million copies.
Initially, the technology was tested on rabbits. The device also allows you to build up jaw bone, which will greatly help children with hemifacial microsomia, a disease in which one side of the child's jaw remains underdeveloped in relation to the other. It is usually treated surgically.
All dental restoration techniques from various authors have several common points, which are listed below:
1. Mental teleportation in time. Researchers recommend transporting yourself in your imagination or in meditation to the age of 13-15 years, when all the baby teeth are already gone, but the molars are still healthy. Imagine yourself at this time as best as possible, possibly using photographs. Remember as many exciting moments from this period of life as possible...
2. Work with the energy-information field. The goal is to implant or transfer the “embryo” of a healthy tooth to the place you need. According to Mikhail Stolbov - giving the order to a tooth to grow. Subsequently, there is a constant mental visualization of beautiful, shiny, white teeth.
3. Daily, according to some methods, hourly maximum attention to the right place, constant stimulation (both physical and psychological), increased blood flow, massage of the gums with a toothbrush, jaw training.
Reader comments:
2 years ago, a wisdom tooth was pulled out, an x-ray was taken, the gums were empty. A year later, he began to grow a tooth in the same place. Now I have already grown more than half of the tooth. As soon as I finish, I'll move on to the rest. There is no secret here; this was in the order of things for our ancestors. I also know a person who grew a tooth.
You don’t even need practice, just trust yourself and believe in the result. Great placebo =) And that’s why various practices exist, to tune you into the right wave.
Stepan Rudakov
About 15 years ago, on the people (Yandex sites), there was a forum dedicated to this issue, military pensioners, with bad scans of photos of their extended teeth, shared their experience, although they had salt + electricity, with small currents, they fused their teeth in this way, I don’t remember about the fortress, but they were definitely whiter in color than their relatives.
Alexander Dvornikov
Below is a fragment from ]]> an unfinished book ]]> by Mikhail Stolbov (the author died in an accident), where Mikhail shares his experience of growing 17 new teeth.
It all started in 1978, when I was serving my required three years of military service on Russian Island. It was then and there that they knocked out almost all my teeth with a stool. Then I terribly hoped that I would be immediately commissioned, but at government expense, within a week they made false jaws for me, and for the remaining 2.5 years, because of my burr, I was “Mongrel” for everyone. Dentures It’s an unpleasant thing, but not fatal... and it’s not something one gets used to.
Over the following years, I repeatedly replaced these dental prostheses with new ones and had already resigned myself to my fate, but some time ago I found myself “locked” in the Siberian taiga for almost a year. There I was overtaken by a disease, due to which I could not wear prostheses for longer than 15-20 minutes a day. Any object and even my own language caused me pain. Food had to be turned into porridge and swallowed without chewing. The process of eating turned into flour and dragged on for forty to sixty minutes. Besides, I couldn't talk! After all, teeth, in collaboration with the tongue, participate in the formation of the sounds T, D, Z, N, R, S, C, Ch; and together with the lips in the formation of the sounds V and F. Fortunately, at that time in the guardhouse near Razdolny I had no one to talk to... But there was no one to save me either. I was very painful and scared. This is what made me start looking for ways to GROW new teeth.
As of today, I have 17 (SEVENTEEN!!!) new teeth of my own, which have grown contrary to all the claims of modern medicine. During this year, a lot of different events happened in the taiga, and I don’t know what exactly played a role in the occurrence of the miracle. Therefore, in my book I will try to carefully repeat the discoveries that I made in the taiga and describe the actions that helped me become sharp-toothed again.
I will try to list them and write each one sequentially.
· Changing our worldview - learning to believe in miracles
· Quit smoking
· We accumulate energy (reset overweight)
· Learning to listen to your body
· Learning to listen to your soul
· Learning to listen to the World
· Growing teeth
Several letters:
“Hello Mikhail! I was glad to find your work on growing teeth on the Internet. I had all my teeth removed and recently discovered the growth of two new teeth. I can’t explain the reason for this and for now I’m just observing the process... I’m really looking forward to finishing your book. The teeth were completely removed a year and a half ago and these two teeth are growing NEW. I don’t have a serious technique, with the exception of water charging and the “Chew-bite” exercise, and the formula “Where there is thought, there is energy, where there is energy, there is blood.”
I am 46 years old. Alexander".
“I grew two teeth. The essence of results is motivation, at least that was the case for me. Initially, I just wanted to reanimate my teeth, in terms of aesthetics, but gradually I realized that they just don’t react like that. It all started when the teeth became vitally important and simply began to fall out of the gums. That’s when the first results appeared. The pain was incredibly acute, especially in the first 2 days and when the gums broke through in some places. 2 teeth appeared, but not in the place of the old ones, but nearby, though without curvature. In other words, the result is 2 new teeth and after six months of work there were no more results.”
“When my side tooth was pulled out, the front two teeth moved apart and there was a very wide and ugly gap between them. Because of this, I was terribly worried and complex. Imagine my surprise when, after some time, another tooth GROWED in this gap!!!”
“I would never have believed it! But, having found your articles on the Internet, I decided to try it and three days ago I got a new tooth!!! At first I didn’t understand anything! Something stings my tongue and that’s it. Yesterday I saw: the infection is creeping!!!”
“Hello, Mikhail! I have one tooth with history. That is, I have had a cyst there for a long time; several years ago we intensively treated it. Today they took a picture, and it turned out that the bone tissue between the roots had been restored, which, in principle, cannot be, as my dentist told me.”
Quotes from forums:
“Anatoly: Cultivated purely deliberately. He created a mental image of teeth where they no longer existed. In a couple of months, 4 beautiful white ones grew like snow. But our dentists are typical barbarians. They began to prove that this was an anomaly, that these were wisdom teeth (after 50 years) and before I had time to come to my senses, all 4 of my handsome teeth were brutally removed without anesthesia. A repeated attempt to grow new ones did not lead to anything. The fact is that I went to these barbarians to build a bridge and they “proved” to me that these teeth would not only interfere, but also harm. And faith in Soviet medicine was higher than faith in one’s own abilities, so...” http://magov.net/blog/135.html
“It so happened that I put off dental treatment until the last moment, always believing that I could do it on my own, and even I think at one time it worked out - I mentally “scanned” the jaws, imagining how strength appeared in the teeth and blood flow increased, but somehow not systematically . And suddenly, in the place of the tooth pulled out in the army, something appeared. I didn't know what to think. On the one hand, the army may not have completely removed the tooth and it could have been a remnant of the root; on the other hand, what appeared was absolutely smooth and neat (!!!) Then suddenly a spot appeared on its surface (it protruded by 1-2 mm) which quickly began to turn into caries. And then, because of another tooth, my cheek became swollen and I had to go to the clinic where the doctor, along with the damaged tooth, pulled out this piece. Naturally, no one paid attention to all my attempts to draw attention to the fact that it might not be a fragment (and I was good - under the injection and even panicked by visiting the clinic - I was not particularly persistent). In short, about 4 years have passed since that event and I gave up (there’s nothing left to chew).”
http://www.e-puzzle.ru/forum/lofiversion/index.php/t350.html
“And here’s what one acquaintance, a former Khalulayevo member (one of the former special forces elites in Primorye), told me. Once he met a Buddhist monk in the taiga, he was looking for grass. got acquainted. He said that it is possible to grow teeth, for this you need a special mood (possibly meditation), a certain set of herbs, and most importantly, you need to be in the taiga for three months. Apparently, being in nature is a must (not everyone who wants to go to the Primorsky or Siberian taiga). Herbs, I think, are needed to cleanse the body, nature - to gain energy, meditation - for pure thoughts, a mood - for teeth growth.” http://forum.anastasia.ru/topic_21135_30.html
Officially recognized by medicine, the fact of tooth growth at the site of the removed one:
Baby teeth appear in a child in the first year of life, and over time they are replaced by molars. After this, only dentures can appear in the mouth. No matter how modern and beautiful they may be, they are no longer real teeth. It would be nice if doctors could grow real teeth instead of extracted ones! Is this possible?
Attempts to grow new ones for humans healthy teeth have been attempted several times. What came of it? What are the prospects for such a technique?
What genes are responsible for the growth and development of teeth?
A few years ago, there was a report in the press that Japanese scientists were able to grow new teeth. Indeed, such work was carried out. In 2007, mice became the owners of artificially grown young teeth. Their teeth performed all the necessary functions, but had no roots. It was only in 2009 that the real indigenous ones were grown.
How is this possible? Scientists from Zurich have found the gene responsible for tooth growth. They also discovered a region of the chromosome responsible for the development and formation of the crown. It turned out that the rudiments from which teeth develop are formed by the operation of the Msx1 gene, and another gene, Osr2, is responsible for the correct position of the crown. Its function is very important. With its anomaly, teeth grow in unexpected places and have a strange shape. The development of teeth is determined by the functioning of a part of the chromosome called Notch.
Is it possible to grow new molars to replace those removed in adults?
This article talks about typical ways to solve your issues, but each case is unique! If you want to find out from me how to solve your particular problem, ask your question. It's fast and free!
Everyone knows that the cells of the human body are completely replaced at certain periods throughout life. Each type of cell takes a different time to renew. Epithelial cells of the stomach are renewed in 5 days, while in bone cells the process occurs within 10 years. Only the teeth, having begun to decay, “finish the job”, and only the roots remain, which have to be removed in order to install a prosthesis (we recommend reading:). Why does this happen? Why are the tissues of the coronal part not capable of regeneration?
No one has an answer yet. But the Japanese have learned to restore dentin in dogs by filling carious cavity special biomass. It took 2 months to recover. Experiments in this direction are ongoing. Interesting results were also obtained in America: scientists have learned to stimulate the restoration of their own tissues in some animals using ultrasound pulses. When will it be people's turn?
It seems incredible that the appearance of a third generation of teeth in an adult. However, it happens that even without the use of special technologies, teeth can change. There are known cases when the change occurred in very elderly people. A new generation of teeth, the third in a row, has grown in people who have celebrated or are approaching their centenary. Where did these teeth come from?
Chewing organs develop from rudiments located in the gingival tissues. Usually, a baby develops two sets of rudiments at once: for baby teeth and for molars. However, even in the body of old people, rudimentary cells are preserved, which can begin to develop when certain conditions occur. Unfortunately, this phenomenon is extremely rare, but modern medicine is working to stimulate the process artificially.
Innovative technologies
Theoretically, teeth can be grown at any age, even for people over 50 years old. It is possible to change genetic information in order to activate the growth of a new tooth instead of an extracted one. However side effects Such effects are completely unpredictable, so such methods have no chance of becoming widespread in the near future.
Methods of influencing the gene responsible for the development of teeth have been tested on dogs and have given good results. However, according to expert assessments, doctors will begin to perform similar procedures on people no earlier than in 20 years.
Stem cells
A promising method of regeneration is growing new organs from stem cells. Stem cells, using special stimuli, create a new tooth germ. Then scientists place the resulting blank in right place and wait. The organ develops independently, and the use of native stem cells eliminates the possibility of tissue rejection.
Individual units of teeth have been learned to grow, but the difficulty lies in obtaining stem cells. This procedure is very painful. In addition, it was possible to grow a tooth only in laboratory conditions, and not in the human body.
They are trying to use stem cell-based drugs to initiate the growth of teeth to replace lost ones. In parallel, work is underway to program the size and shape so that the resulting organ is identical to its predecessor.
Ultrasound
Low-intensity ultrasound pulses can awaken regeneration processes in bone tissue. If you apply them to a diseased tooth, this can lead to its restoration. With this effect, you can even grow a new tooth unit at the site of removal. The gum bone tissue also responds to the impulses and begins to grow. This allows you to correct the underdevelopment of one of the jaws. Unfortunately, all these wonderful transformations so far only work well on rabbits.
Canadian scientists have developed an innovative device the size of a pea. Placing it on the gum helps strengthen it. Ultrasonic radiation reaches the tooth root, and deep massage produced by pulses promotes speedy regeneration fabrics. Root restoration allows you to install dentures and not worry about their strength and durability. Unexpected side effect impact was the growth of a new tooth.
Laser exposure
There is an assumption that tooth regeneration will also occur under the influence of laser beam low power. Irradiation of stem cells should lead to the formation and growth of a new tooth. However, this technology is at the beginning of its development, has not been tested on humans, and it is too early to talk about its effectiveness.
Growing teeth instead surgical intervention and prosthetics - a long-standing dream of humanity. Attempts to find ways to grow new teeth have been made repeatedly. Absence medical technologies led to efforts to regenerate teeth through the power of mental influence.
Folk and shamanic methods of growing teeth at home
It’s not just scientists who are trying to get teeth to replace lost ones. This problem has been troubling humanity for a long time. Numerous healers and traditional healers have repeatedly tried to develop techniques to promote dental regeneration. Fans of folk wisdom and various mental and spiritual practices are convinced that with the power of thought, awakening internal forces humans are capable of growing a second generation of molars. Popular techniques are presented in the video.
Method of self-healing of teeth according to Norbekov
Mirzakarim Norbekov suggests carrying out the process of growing teeth by force of will yourself, at home. The essence of self-healing practice is to activate cellular activity using breathing exercises.
Breathing exercises are designed for a month. It is suggested to do them in the morning, starting with light breaths and ending with deeper ones - 10 times. Then the exercise is repeated in reverse order. According to Norbekov, after finishing gymnastics, you should concentrate on the area where the tooth should reappear. Before going to bed, you should also focus on this area, mentally imagining the union of cells and the process of formation and growth of the missing bone formation. After 2 weeks, a tingling sensation should appear in the selected area. It indicates that the process has gone in the right direction.
Self-hypnosis according to Shichko
In Russia, other home methods for restoring teeth through willpower are also known. One of them belongs to the biologist Shichko. Initially, the method was intended to rid patients of pathological addictions. The biologist is confident that when going to sleep, in a semi-conscious state, a person is able to adjust his subconscious, giving it the right direction. The methodology is based on the following basic principles:
Stolbov's technique
Mikhail Stolbov suggests using a similar method, claiming that he managed to grow 17 teeth to replace the lost ones. He recommends: The practice developed by Sergei Veretennikov suggests growing new teeth, acting in a natural sequence. He suggests growing them, starting with the lower incisors and further in the sequence in which they grow in babies, right up to wisdom teeth. The practice requires half an hour a day.
Veretennikov advises imagining future teeth in the form of seeds located in the gums in conditions favorable for germination. Using auto-training, you should induce in the relevant areas sensations of itching, blood flow, warmth and swelling of the gum tissue. This process should take 10 minutes. It is then recommended to concentrate on the lower incisors. Sensations of squeezing and itching will mean that the growth process has begun.
The last stage is concentration in the third eye area. At the same time, it is necessary to convince yourself that “my teeth are growing young, strong and white.” The process must last at least 3 months. It is also suitable for replacing diseased teeth with new and healthy ones, but you just need not be afraid of losing old teeth.
Criticism
Most experts are skeptical about the fundamental possibility of growing new teeth for a person. The behavior of stem cells cannot be predicted; there are no techniques to control their development. We cannot exclude the possibility of mutations that will not lead to the result that was expected.
Shamanic methods and folk wisdom also do not provide any guarantees. You can’t count on the power of thought; in any case, only a dentist can provide the most reliable help in this problem.