Owner registration certificate:
MERZ PHARMA GmbH & Co. KGaA

Produced:
IMPFSTOFFWERK DESSAU-TORNAU GmbH

ATX code for XEOMIN

M03AX01 (Botulinum toxin)

Analogues of the drug according to ATC codes:

Before using XEOMIN you should consult your doctor. These instructions for use are for informational purposes only. To get more complete information Please refer to the manufacturer's instructions.

Clinical and pharmacological group

02.036 (Muscle relaxant. Acetylcholine release inhibitor)

Release form, composition and packaging

Lyophilisate for preparing a solution for intramuscular administration, white.

Excipients: sucrose, whey.

Bottles (1) - plastic pallets (1) - cardboard packs.

Pharmacological action

Muscle relaxant. Acetylcholine release inhibitor. Xeomin acts selectively on peripheral cholinergic nerve endings, inhibiting the release of acetylcholine. Introduction into cholinergic nerve endings occurs in 3 stages: binding of the molecule to external components of the membrane, internalization of the toxin by endocytosis, and translocation of the endopeptidase domain of the toxin from the endosome to the cytosol. In the cytosol, the endopeptidase domain of the toxin molecule selectively cleaves SNAP-25, an important protein component of the mechanism that controls membrane movement of exovesicles, thereby stopping the release of acetylcholine. The end effect is relaxation of the injected muscle.

The effect of the drug begins, on average, within 4-7 days after injection. The effect of each procedure usually lasts 3-4 months, although it can last significantly longer or shorter.

Pharmacokinetics

Data on the pharmacokinetics of the drug Xeomin are not provided.

XEOMIN: DOSAGE

The drug should only be administered by doctors who have special training and experience in handling botulinum toxin and electromyography equipment. The doctor sets the dosage and number of injection sites into the muscle individually for each patient.

Blepharospasm

After dissolution, Xeomin is administered with a sterile needle No. 27-30 G. The recommended initial dose is 1.25-2.5 units (0.05-0.1 ml) at each injection site. The drug is injected into the medial and lateral parts of the circular muscle of the eye (m. orbicularis oculi) upper eyelid and into the lateral part of the orbicularis oculi muscle of the lower eyelid.

If vision is impaired due to spasms in the forehead, lateral orbicularis oculi muscle, and upper face, additional injections may be given to these areas. The effect of the drug begins, on average, within 4 days after injection. The effect of each procedure usually lasts 3-4 months, although it can last significantly longer or shorter.

If the effect of the initial dose was insufficient (duration less than 2 months), with repeated procedures the dose of the drug can be doubled. The initial dose should not exceed 25 units per eye. A dose of more than 5 units should not be administered to each site. When treating blepharospasm, the total dosage over 12 weeks of treatment should not exceed 100 units.

Spasmodic torticollis

When treating spastic torticollis, the dosage should be selected individually, depending on the position of the neck and head, the location of pain, muscle volume (hypertrophy, atrophy), the patient’s body weight, and his response to therapeutic procedures. In practice, the maximum dose of the drug during one procedure should usually not exceed 200 units, but dosages up to 300 units are possible. A dose exceeding 50 units should not be administered to the same site.

Treatment for spasmodic torticollis includes injections into the sternocleidomastoid muscle, levator scapulae muscle, scalene muscle, splenius muscle, and/or trapezius muscle(s).

Injections into both sternocleidomastoid muscles should not be given as this increases the risk of adverse drug effects (particularly dysphagia) that occur with bilateral drug injections into this muscle or at doses greater than 100 units. For injections into superficial muscles, needles No. 25, 27 and 30 G are used, and for deep muscles, a needle No. 22 G is used.

In spastic torticollis, electromyography may be necessary to determine the muscles involved. Injecting into several places allows the drug to evenly cover muscle areas affected by dystonia (especially when injecting into large muscles). The optimal number of injection sites depends on the size of the muscle. The effect of the drug begins, on average, within 7 days after injection. The effect of each procedure lasts approximately 3-4 months, but may last significantly longer or shorter. The interval between procedures should be at least 10 weeks.

Dissolution of the drug

When diluting the drug, do not open the bottle by removing the stopper.

Remove the protective plastic cap from the bottle. Immediately before diluting the contents of the bottle, the central part of the stopper should be treated with alcohol.

The injection solution is prepared by piercing the stopper with a sterile needle and introducing a sterile 0.9% sodium chloride solution into the vial. Carefully turn the bottle, mixing the lyophilisate with the solvent until completely dissolved. After dissolution, a clear, colorless solution is formed.

The drug should not be used if, after dissolution, the resulting solution is opaque or contains visible flakes and particles. The drug is dissolved in the required volume, according to the table.

Since the drug does not contain antimicrobial agents, it is recommended to use it immediately after dissolution. If necessary, the dissolved drug can be stored in the original bottle for up to 24 hours in the refrigerator at a temperature of 2° to 8°C, provided that the dissolution was carried out under aseptic conditions.

Solvent volume (ml)
U/0.1 ml
0.5
20
1
10
2
5
4
2.5
8
1.25

Overdose

When Xeomin is used in high doses, severe muscle paralysis may develop in areas distant from the injection sites ( general weakness, ptosis, diplopia, difficulty speaking and swallowing, as well as paralysis of the respiratory muscles, leading to the development of aspiration pneumonia).

Treatment: in case of overdose, hospitalization with general supportive measures is necessary. In case of paralysis of the respiratory muscles, intubation and mechanical ventilation are necessary until the condition normalizes.

Drug interactions

Concomitant use with aminoglycosides is not recommended.

Muscle relaxants peripheral action should be used with caution.

The effect of the drug can be reduced with the simultaneous action of 4-aminoquinoline derivatives.

Pregnancy and lactation

The drug is contraindicated during pregnancy and breastfeeding.

XEOMIN: SIDE EFFECTS

Blepharospasm

Common: ptosis (6.1%), dry eyes (2%).

Uncommon: paresthesia, conjunctivitis, dry mouth, skin rash, headache, muscle weakness.

Common: superficial keratitis, lagophthalmos, irritation, photophobia, lacrimation.

Uncommon: keratitis, ectropia, diplopia, dizziness, diffuse skin rashes, dermatitis, entropion of the eyelid, focal paralysis of the facial nerves, weakness of the facial muscles, fatigue, visual disturbances, blurred vision.

Rarely: local swelling of the skin of the eyelid.

Very rare: acute angle-closure glaucoma, corneal ulceration.

Spasmodic torticollis

Common: dysphagia (10%), muscle weakness (1.7%), back pain (1.3%).

Uncommon: inflammation or pressure at the injection site, headache, asthenia, increased sweating, tremor, hoarseness, colitis, vomiting, diarrhea, dry mouth, bone pain, myalgia, skin rashes, itching, peeling skin, eye pain .

In addition, when using a similar drug containing botulinum toxin type A, and used in clinical trials Along with the drug Xeomin, the following side effects were noted. They are also possible when using the drug Xeomin.

Very common: pain.

Common: dizziness, increased blood pressure, feeling of numbness, general weakness, cold symptoms, general malaise, dry mouth, nausea, headache, muscle stiffness, irritation at the injection site, rhinitis, infections upper sections respiratory tract.

Uncommon: shortness of breath, diplopia, fever, ptosis, speech disorders.

Dysphagia usually occurs varying degrees severity (from very mild to strong, with the possibility of aspiration); V in rare cases this requires medical care. Dysphagia may persist for 2-3 weeks after injection, but a case of three-month dysphagia has been reported. Dysphagia develops in a dose-dependent manner. According to clinical trials, dysphagia rarely develops if the total dose of the drug does not exceed 200 IU per procedure.

Common Side Effects

The information presented below is based on data on the effects of other complex preparations containing botulinum toxin type A. Information about severe adverse reactions that may be associated with the lesion cardiovascular system(such as arrhythmia and myocardial infarction, including fatal ones), are extremely insignificant. Were these deaths caused by injections of botulinum toxin type A, or concomitant cardiovascular diseases, has not been precisely established. One case reported anaphylactic shock after administration complex drug, containing botulinum toxin type A.

Side effects such as exudative erythema multiforme, urticaria, psoriasis-like rashes, itching and allergic reactions are noted, but their dependence on the action of a complex drug containing botulinum toxin type A has not been confirmed. Occasionally, after injection of botulinum toxin type A, fluctuations in the electrophysiological background were observed in some distant muscles; this side effect is not associated with muscle weakness or other electrophysiological abnormalities.

Storage conditions and periods

The drug should be stored and transported out of the reach of children, at room temperature (not higher than 25°C). Shelf life - 3 years.

Indications

• blepharospasm;
• idiopathic cervical dystonia (spasmodic torticollis),
• predominantly of a rotational form.

Contraindications

• neuromuscular transmission disorders (myasthenia gravis,
• Lambert-Eaton syndrome);
• elevated temperature;
• acute infectious and non-infectious diseases;
• pregnancy;
• lactation period (breastfeeding);
• age under 18 years;
• hypersensitivity to the components of the drug.

The drug is prescribed with caution for amyotrophic lateral sclerosis, for neurological diseases resulting from degeneration of motor neurons and other diseases with impaired neuromuscular transmission.

Special instructions

Immediately after the injection, the remaining solution in the vial or syringe should be inactivated with sodium hydroxide solution (0.1 N NaOH). All auxiliary materials that have been in contact with the drug must be autoclaved or inactivated for at least 18 hours with sodium hydroxide solution (0.1 N NaOH). Spilled medication should be wiped off with an absorbent cloth soaked in sodium hydroxide solution.

Impact on the ability to drive vehicles and operate machinery

Due to the nature of the diseases treated by the drug, the patient's ability to manage various techniques may be reduced. In addition, the side effects of the drug may negatively affect the patient’s ability to operate equipment; Accordingly, the patient should refrain from such activities until his abilities are fully restored.

Conditions for dispensing from pharmacies

The drug is distributed only to specialized medical institutions.

Registration numbers

lyophilisate for preparation. solution for intramuscular injection 100 units: vial. 1 piece LSR-004746/08 (2023-06-08 – 0000-00-00)

Muscle relaxant means.

Pharmacodynamics and pharmacokinetics

Action of this product, like others botulinum toxins , is based on blocking nerve impulses that are addressed to a specific group of facial muscles. Wrinkles disappear because muscle tissue stops contracting. Eventually they relax injected muscles. The greatest effectiveness is achieved in the forehead, neck, nasolabial folds and around the eyes.

The medicine begins to act approximately within 4-7 days after the injection. The effect of each procedure usually lasts 3-4 months, although it may be less.

Indications for use

The drug is taken for:

• blepharospasm ;
• immobility of arm muscles after surgery;
• idiopathic cervical ;
• facial wrinkles.

Contraindications

This drug is contraindicated in:

• violations neuromuscular transmission ;
• adverse reactions to the components of the drug;
• elevated temperature;
• childhood;
• various acute diseases.

Side effects

The drug usually does not cause adverse reactions. It does not contain complexing proteins, which often provoke.

During therapy blepharospasm Dry mouth, rash, etc. may appear. In addition, it is possible diffuse skin rashes or, lacrimation, , lagophthalmos , irritation, photophobia, fatigue, diplopia , focal paralysis facial nerve, blurred vision, ectropia , weakness of the facial muscles, entropion of the eyelid, visual impairment. In rare cases, local swelling of the skin of the eyelid is possible, corneal ulceration , acute angle-closure .

When treating spasmodic torticollis, it may appear asthenia , painful sensations in the back, muscle weakness, pressure or inflammation at the injection site, headache, increased sweating, hoarseness, bone pain, vomiting, skin rashes, dry mouth, peeling skin, myalgia , painful sensations in the eyes, . In addition, possible upper respiratory tract infections, dizziness, numbness, cold symptoms, irritation at the injection site, increased blood pressure, general weakness, muscle weakness, general malaise, nausea, speech impairment, diplopia , ptosis .

In addition, information is known about some common side effects. For example, such as and.

Instructions for use of Xeomin (Method and dosage)

The instructions for Xeomin recommend applying a special anesthetic cream in advance. The effect of getting rid of wrinkles is noticeable already on the second or third day, the final result comes after 10-14 days. Re-introduction can be carried out maximum once every 4 months. The exact dose and injection site are determined by a specialist.

At blepharospasm It is recommended to administer an initial dosage of 0.05–0.1 ml at each injection site. The total dosage is no more than 100 units per 12 weeks of therapy. do in medial And lateral parts of the orbicularis oculi muscle. If vision is impaired due to the appearance, additional injections can be given. The effect is noticeable, as a rule, within 4 days after administration. It usually lasts 3-4 months.

If the effect of the drug lasts less than two months, the dosage at repeat procedure can be increased by 2 times. But the initial volume should not exceed 25 units per eye. For each injection site, the maximum dosage is 5 units.

For the purpose of treatment spastic torticollis the dose is selected individually. The maximum dosage during one procedure should not be more than 200 units, but if prescribed by a doctor, up to 300 units can be administered. Maximum dose at the same injection site - 50 units.

Injections are given in sternocleidomastoid muscle ; V scalene muscles ; V trapezius muscle ; V splenius muscle ; into the levator scapulae muscle. But you shouldn't inject in both sternocleidomastoid muscles in one procedure, as this increases the likelihood of side effects. Required quantity injections directly depends on the size of the muscle.

For insertion into the superficial muscles, needles with numbers 25, 27 and 30 G are used. For injections into deep muscles - needles with number 22 G.

It may be necessary to determine the muscles involved. electromyography . The effect of the drug is usually noticeable within a week after use and lasts for a total of 3-4 months. The interval between each procedure should be at least 10 weeks.

It is prohibited to open the bottle by removing the stopper when diluting the medicine. The plastic cap is removed, and the central part of the stopper is treated with alcohol before use. It is then pierced with a sterilized needle. Inject into the bottle isotonic sodium chloride solution 0.9% . After this, the mixture is carefully mixed, turning the bottle, until completely dissolved. lyophilized powder . The solution should eventually turn out transparent, without flakes and particles. For 10 units/0.1 ml of powder there is 1 ml of solvent.

It is advisable to use the solution immediately after preparation. If necessary, it can be stored for about a day in the refrigerator if dissolution was carried out under sterile conditions.

Overdose

This drug in increased dosages can cause severe muscular even in places that are remote from those where the injections were given.

The patient must be hospitalized. General support activities are carried out. If the respiratory muscles are paralyzed, the necessary and mechanical ventilation until the condition returns to normal.

Interaction

It is not advisable to use the drug together with aminoglycosides And spectinomycins . Do with caution injections against the background of application muscle relaxants peripheral action. The effect of the drug may be reduced by the influence of derivatives 4-aminoquinoline .

Terms of sale

The medicine can only be purchased by special institutions that carry out appropriate medical and cosmetic procedures.

Storage conditions

The drug should be kept out of the reach of children. Temperature up to 25 °C.

Best before date

Three years.

Analogs

Level 4 ATX code matches:

For a long time, it was the leader in cosmetology among drugs for skin rejuvenation. This is one of the most popular analogues of Xeomin. In addition, in our time, such quite worthy competitors as Lantox . What it is and which product is more effective is often of interest to clients of cosmetology centers.

Which is better – Xeomin or Botox?

Nowadays the question is, which is better, Xeomin or Botox , is quite relevant. Many people do not know the difference between these drugs and have no idea about their positive and negative properties.

Both drugs are classified as neurotoxins, but they are produced in different countries: Botox - in Germany, and Xeomin - in Ireland. Here are a few of its advantages compared to Botox :

• Does not require mandatory cold storage.
• Not addictive.
• Small dosages required.
• Side effects are rare, while Botox A rash occurs quite often.
• The negative effect of the application is practically unnoticeable, so there are no problems with facial expressions after the procedure.

In addition, there are positive aspects and at Botox :

• Suitable for the treatment of hyperhidrosis.
• A more studied remedy.
• A lasting effect that lasts about six months.

Thus, each of these means has its own positive and negative aspects. You should choose one or another drug for yourself, taking them all into account. In addition, reviews from clients of cosmetology centers can help with this.

Xeomin or Dysport - which is better?

Among the drugs that are used for anti-aging procedures, it is known Dysport . It is also made based on botulinum toxin type A . There are similarities and differences between the two drugs, so you can often come across the question: Xeomin or Dysport – which is better?

The undoubted advantage of the first product is that it does not contain complexing proteins. IN Dysporte they are needed to maintain the integrity of the drug, but they slow down the stimulation of production. In addition, the absence of complexing proteins reduces the likelihood of developing allergic reactions.

However, Xeomin is less effective for people with increased sweating, since it has reduced diffusion properties. So it is more suitable for some patients Dysport .

Which is better - Botox, Dysport or Xeomin?

All three popular drugs to get rid of wrinkles are developed based on botulinum toxin type A . However, each of them has its own nuances. Botox is more popular in the USA. And in Europe the English remedy is used more Dysport , since it is much cheaper, but at the same time is not inferior in properties and indications.

Ultimately, there is no clear answer to the question: “Which is better? Botox, Dysport or Xeomin ? – does not exist. All three drugs serve mainly the same aesthetic injections however, they cannot be interchanged. After all, each of them is created from its own specific substance, so it has its own characteristics, both in safety profiles and in effectiveness. Which remedy will be effective in a particular case, everyone chooses for himself.

Botulinum toxin injections are one of the most effective methods correction of facial wrinkles, successfully used in cosmetology for more than 20 years. The first drug used for these purposes was Botox, later Lantox and Dysport appeared, and one of the latest developments is Xeomin. All products have an identical mechanism of action, since they contain the same active ingredient, but there are differences between them. Thus, there is a lower risk of side effects and more simple conditions storage of xeomin makes it a worthy competitor to Botox in the cosmetic services market.

Content:

Composition of drugs

Botox (botulinum toxin type A) is produced by the American company Allergan and has been used in cosmetology to eliminate facial wrinkles since 1989. Until then active substance this drug, a botulinum toxin produced by the bacteria Clostridium botulinum and is fatal in the wild dangerous poison, used only in medical purposes for the treatment of strabismus and blepharospasm in ophthalmological practice.

Xeomin (incobotulinumtoxin type A) is produced by the German pharmaceutical company Merz. It was approved for use in cosmetology for the correction of facial wrinkles relatively recently, starting in 2011. Despite careful preclinical study of the drug, at the moment experience with its use is not as extensive as compared to Botox, so many cosmetologists are afraid to work with it due to the lack of information about long-term consequences and prefer to use the old proven remedy.

Important: Botox, Xeomin and other botulinum toxin-based preparations used in cosmetology include a weakened neurotoxin, which correct use And strict adherence dosages do not pose a danger to human life.

Both drugs are available in the form of a lyophilisate for the preparation of a solution for intramuscular injection, packed in sterile vials. They differ in composition excipients and the structure of botulinum toxin. Botox contains botulinum toxin type A in a form bound to complexing proteins, when ingested physiological conditions the complex disintegrates, pharmacological action renders already free neurotoxin. Sodium chloride and human serum albumin are used as excipients.

Unlike Botox, Xeomin contains botulinum toxin type A in a free form, that is, not associated with complexing proteins. It contains sucrose and human serum albumin as excipients. It is precisely the absence of complexing proteins, which is achieved by a better degree of purification when isolating the neurotoxin produced in laboratory conditions bacteria Clostridium botulinum, explains all the differences between Botox and Xeomin.

One of the advantages of Xeomin compared to Botox is its higher stability and less strict storage conditions. Unlike Botox, which should be stored at a temperature of 2–8°C for no more than 2–3 years, it can be transported and stored unopened at room temperature for 3–4 years. After opening the bottles, both drugs should be stored at a temperature of 2–8°C and used within 24 hours or discarded.

Mechanism of action

The mechanism of action of both drugs, given that they contain the same active ingredient (botulinum toxin type A), is identical. When introduced into the area of ​​muscles, the constant contraction of which due to active facial expressions has caused the formation of creases in the skin, they lead to blocking the process of neuromuscular transmission and cause temporary relaxation and immobilization of these muscles. As a result, wrinkles are smoothed out, the face looks noticeably better and younger, and, in addition, the person gradually loses the habit of constantly using the muscles when showing any emotions, even after full recovery their mobility. This also serves to a certain extent to prevent the appearance of wrinkles or an increase in their severity.

Advice: Particularly effective for noticeable facial rejuvenation is the combination of botulinum toxin injections with the introduction of fillers based on hyaluronic acid, allowing you to fill creases in the skin, smooth out the relief and stimulate tissue regeneration.

At making the right choice injection zones and administration techniques, both drugs have their neurotoxic effect only at the injection site and do not diffuse into adjacent tissues. There is information that xeomin spreads less into surrounding tissues than Botox, as it binds to its targets faster.

The duration of action of botulinum toxin-based products is usually about 4-6 months, sometimes up to one year. It depends more on individual sensitivity and skin care than on the choice of one product or another. However, some cosmetology experts note that the validity period of Xeomin is 2 months less than Botox. With repeated injections of botulinum toxin, the duration of the paralytic effect of the neurotoxin on the facial muscles increases, which allows women to visit a cosmetologist less often.

Applications

Botulinum toxin preparations are mainly used in cosmetology for women over 25 years of age with the following problems:

• facial wrinkles in the eye area (“crow’s feet”);
• wrinkles on the forehead, between the eyebrows and on the bridge of the nose;
• facial asymmetry;
• the need to correct the shape of the eyebrows;
• increased sweating palms, feet and armpits.

According to some cosmetologists, Xeomin is better than Botox to use for correcting wrinkles in the lips, chin and neck, since it has a lower risk of adverse reactions such as drooping corners of the lips and sagging skin. On the other hand, due to its lower degree of diffusion into surrounding tissues, it is less effective than Botox for eliminating hyperhidrosis, so it is not used for these purposes.

Xeomin, like Botox, has indications for use not only in cosmetology, but also in medicine. It may be useful in the treatment of blepharospasm, cervical dystonia, and muscle spasticity after a stroke.

Warning: The selection of a specific botulinum toxin preparation (Botox, Dysport, Xeomin, Lantox or another) is made by a cosmetologist. After examining the client, analyzing her health status, skin characteristics and the range of problems that need to be solved, he will advise which product will have the best effect.

Contraindications and side effects

Xeomin began to be used in cosmetology relatively recently, therefore, despite high efficiency and certain benefits, it still raises some concerns due to the lack of sufficient experience with it and confirmation of safety in the long term.

Contraindications for the use of both Botox and Xeomin include:

• pregnancy;
• breast-feeding;
• myasthenia gravis and muscle weakness;
• neurological disorders;
• any inflammatory processes on the skin at the intended injection sites;
• oncological diseases;
• exacerbation of chronic diseases;

The absence of complexing proteins in Xeomin has reduced the risk of local allergic reactions compared to Botox. These include redness, swelling, rash, and swelling at the injection sites. This is due to the fact that the causative agents of allergies in humans are most often foreign proteins. Xeomin is also considered the best because it is not addictive, its effectiveness remains unchanged, in response to its intake the body does not produce an immunological response, and antibodies are not produced to it.

Price

The cost of a bottle of Xeomin containing 100 units of botulinum toxin is approximately 20% less than Botox containing 100 units of botulinum toxin.

Things to consider: Although empirically It was found that the coefficient of interchangeability of drugs is 1 to 1; each manufacturer calculates the activity using its own method.

Video: Cosmetologist about the benefits and use of xeomin

Xeomin – drug latest generation based on neurotoxin. Created in 2001 by German scientists, registered in Russia in 2008.

It differs from its more well-known predecessors, Botox and Dysport, by a greater degree of purification of active botulinum toxin from complex proteins.
This helps to avoid allergic reactions: rashes, redness and swelling, and also minimizes the risk of addiction to the drug.

When does the effect occur?

After the injection, the toxin penetrates into the nerve ending, where a specific protein is blocked, which is the carrier of acetylcholine, which causes muscle contraction.

As a result of the blockade, nerve impulse transmission does not occur, the muscle does not contract, but relaxes and lengthens. Thanks to this, the surface of the skin is leveled, fine wrinkles disappear, and the depth of creases is reduced.
The effect of Xeomin begins to appear approximately 2 days after administration. The maximum effect occurs after 8–12 days and lasts from three to six months.

Let's look at how to prolong the effect of Xeomin injections.

How to maintain results

To maintain the results achieved as long as possible, you must adhere to following rules behavior before and after the procedure.

A few days before the injection session you need to:

Tell your doctor about all medications you are taking, chronic diseases, allergic reactions, regularly performed cosmetic procedures.
Stop drinking alcohol, reduce the number of cigarettes and cups of coffee you drink.
Do not take aminoglycoside antibiotics, which include: gentamicin, erythro- and streptomycin, as well as blood thinning drugs, including aspirin.

The first few hours after the procedure are most critical for obtaining the optimal final result, so after the injections you should:

For four hours, try not to bend over or take a horizontal position, so as not to provoke redistribution of the drug into neighboring tissues. The procedure itself is also performed in a sitting or reclining position, which ensures maximum muscle relaxation.
During the day, do not touch your face with your hands, do not massage or apply cream to it.
Use active facial expressions to distribute the drug evenly in the muscles.
Limit alcohol intake, especially beer, salty and spicy foods, so as not to provoke the formation of swelling. In addition, alcohol promotes expansion blood vessels and increased blood flow, this can lead to an increase in the area of ​​distribution of the drug and unpredictable consequences.
Do not visit the sauna and solarium for two weeks, as thermal effect promotes the rapid removal of neurotoxin from the muscles. For the same reason, it is not recommended to dry your hair with a hot hair dryer for two days after injections. If you are going to do the procedure before going to the sea, plan it at least a week before departure so that the effects of hot sun rays did not accelerate the elimination of neurotoxin.
Reduce for about a week motor activity, give up intensive sports training.
Avoid taking B vitamins and performing physiotherapeutic procedures: massage, microcurrent myostimulation.
Do chemical peeling no earlier than a week and a half after the injections.

If you follow all the instructions, then a face that has retained facial expressions, but is youthful and refreshed, will delight you for at least six months on average.

The history of the long-term and still relevant use of botulinum toxin to smooth out wrinkles began more than 25 years ago. But initially it was implemented in medical practice as part of Botox for the treatment of hemispasms on the face and neck, as well as hyperhidrosis. It was only in the 2000s that the drug's name began to appear in television news reports about movie stars using it for other purposes than for its intended purpose, but to treat fine lines and wrinkles. Today there is no need to use strong drugs with contradictory results if there are easy analogues. For example, German drug Xeomin does not claim to take the place of Botox in cosmetology, but has become a life-saving alternative for doubting patients.

Origin and principle of action of the drug

In Russia, the drug has been registered and approved for use since 2008. The development of the drug took place in the German company Merz Aesthetics under the leadership of Jurgert Friwert and was completed in 2001. The idea of ​​​​creating Xeomin relates exclusively to the field of wrinkle correction.

In front of the client is a small bottle with a blue label and injection powder. Before the cosmetologist - a drug for botulinum therapy of the second generation A-type. It works the same way as similar drugs based on botulinum toxin: blocks the nerve endings of the facial muscles. Without receiving impulses, the muscles remain in a relaxed and motionless state, remaining amorphous to emotions and reflective urges.

Of course, this will not always be the case, and new nerve cells are formed in muscle tissue after 3-4 months. But during a period of absolute immobility muscle fibers the skin over them is smoothed out.

Obviously, the maximum effect from using Xeomin will be achieved when injecting areas of facial wrinkles. Where there are nasolabial folds, crow's feet, and horizontal lines on the forehead, botulinum toxin suppresses the reflexive contraction of muscle fibers, and they have to rest involuntarily.

Xeomin under a microscope

The simplicity of the composition guarantees the comparative safety of the procedure. To ensure the safety of the drug, protein complexes are usually used. Since a person has his own protein, then:

• The protein in the muscle relaxant can cause the production of antibodies and rejection of botulinum toxin. The injection will not work.
• Antibodies against the foreign protein are gradually formed, and the muscle’s susceptibility to botulinum therapy with a specific drug decreases. The body gets used to it, and the dose has to be increased.
• An allergic reaction may occur.
• The safety of the drug depends on the temperature in which it is located.

The peculiarity of the drug formula lies in its low molecular weight, which is 150 kilodaltons. This is the most low rate among botulinum toxins. For cosmetologists and patients, this is an additional advantage - the product acts on the smallest muscles of the face, and only in the area of ​​invasion. To carry out the procedures you need much less than similar products.

The composition and formula of the drug make it not only good remedy to eliminate facial wrinkles, but also a convenient drug that does not cause specific problems. By looking at the reviews, you can be sure of this.

Progress of the procedure

Xeomin injections take about 30-40 minutes and are usually painless. The protective plastic cover is removed immediately before the procedure. Then you need to inject it into the bottle using a needle. required quantity sodium chloride solution 0.9%. The instructions for use of the drug contain all the data on the dosage of sodium chloride in tabular form.

After the puncture points on the face are identified, an anesthetic is applied to the skin, and then injections are made. 3-5 days after the procedure, the blocking effect of botulinum toxin begins to appear. Facial muscles constrained by short-term paralysis, which will end in 3-4 months. During this time, wrinkles are noticeably smoothed out, which is confirmed by the photo. The difference between “before” and “after” is pronounced.

Photos before and after No. 1

Photos before and after No. 2

Photos before and after No. 3

Photos before and after No. 4

Photos before and after No. 5

For different types corrections and for the treatment of spasmodic diseases are used different dosages in units (0.1 ml). They are determined by a specialist individually for each case.

Contraindications for use

No matter how good Xeomin may be, it is toxic and requires caution. Therefore, contraindications to the injection use of the drug, as well as a number of precautionary measures should be studied. This:

• pregnancy;
• breast-feeding;
• minor age;
• diseases associated with muscle weakness;
• glaucoma;
• taking antibiotics;
• allergic and infectious diseases;
• hemophilia;
• pustular rash, eczema, acne in the area of ​​the intended injection.

Usually the photo shows the final aesthetic result, but side effects are not excluded. They are not associated with a reaction to the drug, but with insufficiently qualified execution of the procedure. This may be ptosis of the treated skin surface, curvature of natural facial features, asymmetry, or headache.

Choose a specialist carefully for the procedure