Diclofenac gel - instructions for use. What does Diclofenac gel help with, analogues and price. Methods of using diclofenac gel

NSAIDs for external use.

Drug: DICLOFENAC
Active substance: diclofenac
ATX code: M02AA15
KFG: NSAIDs for external use
Reg. number: LSR-000076
Registration date: 05.28.07
Owner reg. cred.: SYNTHEZ JSC (Russia)

DOSAGE FORM, COMPOSITION AND PACKAGING

? Gel for external use 1%

Excipients: rectified ethanol, propylene glycol, carbopol (carbomer), methyl parahydroxybenzoate (nipagin), triethanolamine (trolamine), lavender oil, purified water.

? Gel for external use 5% white or white with a yellowish or creamy tint and a specific odor.

Excipients: ethanol, propylene glycol, carbomer, methyl parahydroxybenzoate, triethanolamine (trolamine), lavender oil, purified water.

30 g - aluminum tubes (1) - cardboard packs.

The description of the drug is based on the officially approved instructions for use.

PHARMACOLOGICAL ACTION

NSAIDs for external use.

Diclofenac has pronounced analgesic and anti-inflammatory properties. By indiscriminately inhibiting the enzymes COX-1 and COX-2, it disrupts the metabolism of arachidonic acid and the synthesis of prostaglandins, which are the main link in the development of inflammation.

Used to eliminate pain and reduce swelling associated with the inflammatory process. When applied topically, it causes a weakening or disappearance of joint pain at rest and during movement. Reduces morning stiffness and swelling of the joints, helps to increase range of motion.

PHARMACOKINETICS

INDICATIONS

Post-traumatic inflammation of soft tissues and joints due to sprains, strains and bruises;

Rheumatic diseases of soft tissues (including tenosynovitis, bursitis, damage to periarticular tissues);

Pain and swelling associated with diseases of muscles and joints (incl. rheumatoid arthritis, osteoarthritis, radiculitis, lumbago, sciatica);

Muscle pain of rheumatic and non-rheumatic origin (for gel 5%).

DOSING REGIME

Externally. The amount of the drug depends on the size of the painful area. Single dose 1% gel is 2-4 g (volume comparable to the size of a cherry or walnut). A single dose of gel 5% - up to 2 g (about 4 cm with the neck of the tube completely open).

For adults And children over 12 years of age the drug should be applied to the skin 3-4 times a day and lightly rubbed.

Children aged 6 to 12 years the drug in the form of a 1% gel should be applied to the skin no more than 2 g (per application) up to 2 times a day; the drug in the form of a gel 5% - no more than 1 g (about 2 cm with the neck of the tube completely open) per application up to 2 times a day.

After applying the drug, hands must be washed. The duration of treatment depends on the indications and the observed effect. After 2 weeks of using the drug, you should consult your doctor.

SIDE EFFECTS

Local reactions: eczema, photosensitivity, contact dermatitis(including itching, redness, swelling of the treated area of skin, papules, vesicles, peeling).

Systemic reactions: generalized skin rash, allergic reactions(including urticaria, angioedema, bronchospastic reactions), photosensitivity.

CONTRAINDICATIONS

Integrity violation skin;

A history of attacks of bronchial asthma after the use of NSAIDs and salicylates;

III trimester of pregnancy;

Lactation period;

Children's age (up to 6 years);

Hypersensitivity to diclofenac or other components of the drug;

Hypersensitivity to salicylates or other NSAIDs.

WITH caution the drug should be used for hepatic porphyria (exacerbation), erosive and ulcerative lesions Gastrointestinal tract, severe violations liver and kidney function, chronic heart failure, bronchial asthma, in the first and second trimesters of pregnancy, in elderly patients. Additionally, for the drug in gel form, 5% should be used with caution in case of bleeding disorders (including hemophilia, prolonged bleeding time, bleeding tendency).

PREGNANCY AND LACTATION

The use of the drug is contraindicated in the third trimester of pregnancy. Use in the first and second trimesters is possible only after consultation with a doctor.

There is no experience with the use of the drug during lactation.

SPECIAL INSTRUCTIONS

At long-term use large quantities of the drug, the appearance of systemic side effects, characteristic of NSAIDs.

OVERDOSE

Extremely low systemic absorption active ingredients When used externally, the drug makes overdose almost impossible.

Symptoms: In case of accidental ingestion of large quantities of gel (more than 20 g), systemic symptoms may occur. adverse reactions, characteristic of NSAIDs.

Treatment: you should rinse your stomach, take activated carbon.

DRUG INTERACTIONS

The drug may enhance the effect of drugs that cause photosensitivity.

Clinically significant interactions with others medicines not described.

CONDITIONS OF VACATION FROM PHARMACIES

The drug is approved for use as an over-the-counter product.

CONDITIONS AND DURATION OF STORAGE

The drug should be stored in a dry place, out of reach of children, at a temperature of 15° to 25°C; do not freeze. Shelf life - 2 years.

Diclofenac gel is well absorbed into the skin and quickly provides therapeutic effect on sore joints. But its list of contraindications is quite wide. Therefore, the drug should be used only as prescribed by a doctor.

Composition, release form and packaging of Diclofenac gel

The gel is packaged in aluminum tubes of 30 g, 50 g, 100 g. Each is enclosed in cardboard box along with instructions for use. The concentration of the active ingredient (diclofenac sodium) is 1%, 3% or 5%.

The auxiliary composition is represented by the following components:

sodium benzoate;
carbomer;
trolamine;
disodium edetate;
dimethyl sulfoxide;
propylene glycol;
macrogol;
purified water.

Diclofenac in gel form is produced by many domestic pharmaceutical factories, so the composition may vary slightly. For example, 5% gel from “Sintez” contains lavender essential oil.

Pharmacological action

Consequences of overdose

There were no cases of overdose. If you accidentally swallow Diclofenac gel, you need to quickly rinse your stomach and then take an enterosorbent - activated carbon, Smecta, Enterosgel.

Possible unwanted effects

Systemic and local side effects Diclofenac gel occurs quite rarely. Usually they are provoked by violations of the dosage regimen, applying the drug to large areas of the skin.

In what cases is the drug contraindicated?

The drug is not prescribed to patients if they have hypersensitivity to diclofenac or auxiliary ingredients. Absolute contraindication- “aspirin triad”. This is the name of a condition in the body in which taking aspirin or NSAIDs leads to attacks of bronchial asthma, urticaria, acute rhinitis. Contraindications also include the 3rd trimester of pregnancy, lactation, and age under 6 years.

The medicine should not be applied to skin with microtraumas - abrasions, cuts, burns, cracks.

Special instructions

If after 3-5 days of using Diclofenac gel the intensity of the symptoms of any disease does not decrease, you should consult your doctor. He will clarify the diagnosis, make changes to the dosage regimen, or prescribe a more effective external remedy.

Interactions with other substances

Diclofenac gel should not be used simultaneously with drugs, one of the side effects of which is sensitization. It should be applied to the skin 20-30 minutes after using other external products.

Conditions for dispensing from pharmacies

When purchasing any dosage form with diclofenac for external use, a prescription from a doctor is not required.

Storage periods and rules

The shelf life of the medicinal gel is 24 months. It must be stored at room temperature in places protected from direct sun rays. The drug cannot be used for treatment if its consistency, color or smell changes. Access for small children to the gel storage area should be limited.

Diclofenac gel analogs

Replace Diclofenac gel with current or structural analogue Only the attending physician can. All drugs that contain NSAIDs have similar therapeutic properties.

"Voltaren emulgel"

"Diclobene gel"

Indications for use of 1% Dolobene are the same as for Diclofenac gel. The German drug is used in the treatment of both inflammatory and degenerative diseases of the joints and spine.

"Dicloran"

The composition of the Dicloran gel, in addition to NSAIDs, includes flax seed oil, levomenthol, and methyl salicylate. These components enhance and prolong the effect of the active ingredient. Due to levomenthol, when applying the drug, a pleasant feeling of coolness occurs. A linseed oil nourishes and moisturizes the skin.

"Naklofen"

The active ingredients of Naklofen are diclofenac diethylamine and diclofenac sodium. The gel has a pronounced anti-inflammatory, analgesic, and antipyretic effect. Spectrum of use, lists of contraindications and adverse reactions Naklofen and Diclofenac are identical.

Nonsteroidal anti-inflammatory drugs

Name

gel for external use 5%

Pharmacotherapeutic group

Nonsteroidal anti-inflammatory drug (NSAID)

Trade name

Diclofenac

International nonproprietary name

Diclofenac

Dosage form

Gel for external use

Compound

Active substance: diclofenac sodium - 5.0 g; Excipients: ethanol, propylene glycol, carbomer, methyl parahydroxybenzoate, trolamine, lavender oil, purified water.

ATX Code

Pharmacological properties

The active component of the drug diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) with pronounced analgesic (painkiller) and anti-inflammatory properties. By indiscriminately inhibiting cyclooxygenase types 1 and 2, it disrupts the metabolism of arachidonic acid and the synthesis of prostaglandins, which are the main link in the development of inflammation.
Diclofenac gel 5% is used to eliminate pain and reduce swelling associated with the inflammatory process. When applied topically, it causes a weakening or disappearance of joint pain at rest and during movement. Reduces morning stiffness and swelling of joints, helps increase range of motion.
With the recommended method of applying the drug, no more than 6% of diclofenac is absorbed.

Indications for use

Post-traumatic inflammation of soft tissues and joints, for example due to sprains, strains and bruises;

Rheumatic diseases of soft tissues (tenosynovitis, bursitis, damage to periarticular tissues);

Pain and swelling associated with diseases of muscles and joints (rheumatoid arthritis, osteoarthritis, radiculitis, lumbago, sciatica, muscle pain of rheumatic and non-rheumatic origin).

Contraindications

Hypersensitivity to diclofenac or other components of the drug, acetylsalicylic acid or other NSAIDs, anamnestic data on an attack of bronchial obstruction, rhinitis, urticaria after taking acetylsalicylic acid or other NSAIDs, pregnancy (III trimester), lactation period, children (up to 6 years), violation of the integrity of the skin.

Use during pregnancy

The drug should not be used in the third trimester of pregnancy. There is no experience with the use of the drug during lactation. Use in the first and second trimesters is possible only after consultation with a doctor.

Directions for use and doses

Externally. For adults and children over 12 years of age, the drug is applied to the skin 2-3 times a day and lightly rubbed. Required quantity The drug depends on the size of the painful area. A single dose of the drug is up to 2 g (about 4 cm with the neck of the tube completely open). For children from 6 to 12 years old, use no more than 2 times a day, a single dose of the drug up to 1 g (about 2 cm with the neck of the tube completely open).
After applying the drug, hands must be washed.
The duration of treatment depends on the indications and the observed effect. After 2 weeks of using the drug, you should consult your doctor.

Side effect

Local reactions: eczema, photosensitivity, contact dermatitis (itching, redness, swelling of the treated skin area, papules, vesicles, peeling).
Systemic reactions: generalized skin rash, allergic reactions (urticaria, angioedema, bronchospastic reactions), photosensitivity.

Overdose

The extremely low systemic absorption of the active components of the drug when used externally makes overdose almost impossible. If large quantities of gel (more than 20 g) are accidentally ingested, systemic adverse reactions characteristic of NSAIDs may occur. It is necessary to lavage the stomach and take activated charcoal.

Use with other drugs

The drug may enhance the effect of drugs that cause photosensitivity. Clinically significant interactions with other drugs have not been described.

Instructions for use Diclofenac
Buy Diclofenac gel 5% 30g
Dosage forms
gel 5%, gel for external use 5%
Manufacturers
Synthesis AKO OJSC (Kurgan)
Group
Anti-inflammatory drugs - phenylacetic acid derivatives
Compound
The active substance is diclofenac sodium.
International generic name
Diclofenac
Synonyms
Voltaren, Voltaren Acti, Voltaren Ofta, Voltaren Rapid, Voltaren Emulgel, Diclak, Diclak Lipogel, Diclo-F, Diclobene, Diclovit, Diclogen, Diclonate P, Dicloran, Diclofenac sodium, Diclofenac retard, Diclofenac retard Obolenskoye, Diclofenac Sandoz, Diclofenac Stada, Diclofenac-Acos, Diclofenac-Acri, Diclofenac-Acri retard, Diclofenac-Altfarm, Diclofenac-MFF, Diclofenac-Ratiopharm, Diclofenac-UBF, Diclofenac-FPO, Diclofenac-Eskom, Diclofenacol, Dorosan, Naklofen, Naklofen Duo, Naklofen SR, Ortofen , Ortofer, Ortoflex, Panamor AT-50, Rapten Duo, Rapten rapid
Pharmacological action
Non-steroidal anti-inflammatory drug. Inhibits the biosynthesis of prostaglandins. Prostaglandins play a major role in the development of the main symptoms of inflammation (swelling, temperature, pain). In rheumatic diseases, anti-inflammatory and analgesic properties cause a reduction in symptoms such as pain at rest and with movement, morning stiffness, and swelling of the joints. Has a pronounced analgesic effect in moderate and severe pain non-rheumatic nature. At inflammatory processes arising after operations and injuries, quickly relieves both spontaneous pain and pain during movement, reduces inflammatory edema at the wound site. In primary dysmenorrhea, it relieves pain and reduces bleeding. Suppresses platelet aggregation. At long-term use has a desensitizing effect. In ophthalmology - eliminates miosis, reduces the likelihood of developing cystoid macular edema during cataract surgery. Absorption is rapid and complete; food slows down the rate of absorption. Maximum plasma concentration is achieved after 1-2 hours. As a result of delayed release active substance The maximum concentration of extended-release diclofenac in the blood plasma is lower than that formed when the drug is administered short acting. With intramuscular administration, maximum plasma concentration is achieved after 10-20 minutes, with rectal administration - after 30 minutes. Bioavailability - 50%. Communication with blood plasma proteins is over 99%. When applied topically active substance partially absorbed through the skin. When instilled into the eye, the onset of maximum concentration in the cornea and conjunctiva is 30 minutes, penetrates into the anterior chamber of the eye, into the systemic circulation therapeutically significant concentrations does not penetrate. Does not accumulate. It is excreted in the form of metabolites through the kidneys and bile.
Indications for use
Inflammatory joint diseases (rheumatoid arthritis, rheumatism, ankylosing spondylitis, chronic gouty arthritis), degenerative diseases (deforming osteoarthritis, osteochondrosis), lumbago, sciatica, neuralgia, myalgia, diseases of extra-articular tissues (tenosynovitis, bursitis, rheumatic soft tissue lesions), post-traumatic pain syndromes accompanied by inflammation, postoperative pain, acute attack gout, primary dysmenorrhea, adnexitis, migraine attacks, renal and hepatic colic, infections of the ENT organs, residual effects of pneumonia. Locally - injuries of tendons, ligaments, muscles and joints, localized forms of soft tissue rheumatism. In ophthalmology - non-infectious conjunctivitis, post-traumatic inflammation after penetrating and non-penetrating wounds eyeball, pain syndrome when using an excimer laser, during surgery for removal and implantation of the lens (pre- and postoperative prevention of miosis, cystoid edema of the optic nerve).
Contraindications
Hypersensitivity, hematopoietic disorders, stomach ulcers and duodenum, "aspirin" bronchial asthma, children's age (up to 6 years), last trimester pregnancy.
Side effect
From the gastrointestinal tract: gastralgia, nausea, vomiting, diarrhea, stomach cramps, dyspepsia, flatulence, anorexia. From the side of the central nervous system: headache, dizziness, fatigue. From the hematopoietic organs: thrombocytopenia, leukopenia, agranulocytosis, hemolytic anemia. There is a burning sensation at the site of intramuscular injection. When using suppositories - local irritation. Skin: skin rashes, urticaria, itching, burning. With long-term use and/or application to large surfaces, systemic side effects due to resorptive effects occur. Immediately after instillation into the eyes - a passing burning sensation and/or blurred vision.
Interaction
Increases blood concentrations of lithium, digoxin, indirect anticoagulants, oral antidiabetic drugs (both hypo- and hyperglycemia are possible), quinolone derivatives. Increases the toxicity of methotrexate, cyclosporine, the likelihood of developing side effects of glucocorticoids ( gastrointestinal bleeding), the risk of hyperkalemia in the presence of potassium-sparing diuretics reduces the effect of diuretics. Plasma concentrations decrease with the use of acetylsalicylic acid.
Directions for use and dosage
Gently rub 2 to 4 g of gel into the skin 2-4 times a day. The course of treatment is 7-14 days.
Overdose
When taken orally: Symptoms: dizziness, headaches, hyperventilation, clouding of consciousness, in children - myoclonic convulsions, disorders of the gastrointestinal tract, liver and kidney functions. Treatment: symptomatic therapy.
Special instructions
In order to quickly achieve the desired effect, oral forms of diclofenac are taken 30 minutes before meals. After removal contact lenses, instillation is carried out after 5 minutes. Medicines for local application Apply only to undamaged areas of the skin. At long-term treatment it is necessary to periodically study the blood count and liver function, stool analysis for occult blood. In the first 6 months of pregnancy should be used according to strict indications and in lowest dosage. Due to a decrease in reaction speed, driving vehicles and operating machinery is not recommended. Restrictions on use. Impaired liver and kidney function, heart failure, porphyria, work requiring increased attention, pregnancy, breastfeeding (breastfeeding should be avoided).
Storage conditions
In a dry place, protected from light, at room temperature.

Gel for external use 5% white or white with a yellowish or creamy tint, homogeneous, with a specific odor.

Excipients:

ethanol, propylene glycol, carbomer (carbopol), methyl parahydroxybenzoate, triethanolamine (trolamine), lavender oil, purified water.

Clinical and pharmacological group:

NSAIDs for external use

Indications

- post-traumatic inflammation of soft tissues and joints due to sprains, strains and bruises;
- rheumatic diseases of soft tissues (including tendovaginitis, bursitis, damage to periarticular tissues);
- pain and swelling associated with diseases of muscles and joints (including rheumatoid arthritis, osteoarthritis, radiculitis, lumbago, sciatica);
- muscle pain of rheumatic and non-rheumatic origin (for gel 5%).

Dosage regimen

Externally. The amount of the drug depends on the size of the painful area. A single dose of 1% gel is 2-4 g (the volume is comparable to the size of a cherry or walnut). A single dose of gel 5% - up to 2 g (about 4 cm with the neck of the tube completely open).
For adults and children over 12 years of age, the drug should be applied to the skin 3-4 times a day and lightly rubbed.
For children aged 6 to 12 years, the drug in the form of a 1% gel should be applied to the skin, no more than 2 g (per application) up to 2 times a day; the drug in the form of a gel 5% - no more than 1 g (about 2 cm with the neck of the tube completely open) per application up to 2 times a day.
After applying the drug, hands must be washed.
The duration of treatment depends on the indications and the observed effect. After 2 weeks of using the drug, you should consult your doctor.

Side effect

Contraindications for use

- violation of the integrity of the skin;
- a history of attacks of bronchial asthma after the use of NSAIDs and salicylates (including acetylsalicylic acid);
- III trimester of pregnancy;
- lactation period;
- children under 6 years of age;
- increased sensitivity to diclofenac or other components of the drug;
- hypersensitivity to salicylates (including acetylsalicylic acid) or other NSAIDs.

The drug should be used with caution in cases of hepatic porphyria (exacerbation), erosive and ulcerative lesions of the gastrointestinal tract, severe dysfunction of the liver and kidneys, chronic heart failure, bronchial asthma, in the first and second trimesters of pregnancy, and in elderly patients.

Additionally, for the drug in gel form 5%: should be used with caution in case of bleeding disorders (including hemophilia, prolonged bleeding time, bleeding tendency).

Use during pregnancy and breastfeeding

The use of the drug is contraindicated in the third trimester of pregnancy. Use in the first and second trimesters is possible only after consultation with a doctor.
There is no experience with the use of the drug during lactation.

Use for liver dysfunction
The drug should be used with caution in cases of hepatic porphyria and severe liver dysfunction.

Use for renal impairment
The drug should be used with caution in severe renal impairment.

Use in children
Contraindicated in childhood up to 6 years old.

Special instructions

The gel should be applied only to intact skin, avoiding contact with open wounds.
After application, do not apply an occlusive dressing.
The drug should not come into contact with the eyes and mucous membranes.
With long-term use of large quantities of the drug, the occurrence of systemic side effects characteristic of NSAIDs cannot be ruled out.

Overdose

The extremely low systemic absorption of the active components of the drug when used externally makes overdose almost impossible.

Symptoms: if large quantities of gel (more than 20 g) are accidentally ingested, systemic adverse reactions characteristic of NSAIDs may occur.
Treatment: rinse the stomach, take activated charcoal.