Panadol: instructions for use. Panadol® soluble tablets

is a drug that has analgesic and antipyretic properties. It is intended for symptomatic therapy, does not affect the etiology of the disease and does not accelerate the healing process. The drug helps with pain syndrome of various origins and localization.

Active substance and dosage form

The active component of Panadol is (1 tablet – 500 mg).

Issued as regular tablets, coated and dispersible. They are supplied in blisters of 6 or 12 pieces.

What does Panadol tablets help with?

Panadol tablets help relieve or reduce pain and fever due to colds and (including ).

Other indications include:

arthralgia;
muscle pain various localizations;
during menstruation;
at or ;
post-traumatic pain (including with);
pain after surgery.

Please note

Paracetamol tablets should not be given to children under 6 years of age. Others are produced for them dosage forms drug - syrup (suspension) and rectal suppositories.

Who should not take Panadol?

A contraindication to treatment with Panadol is hypersensitivity to paracetamol. Great care must be taken if there have been negative reactions to other NSAIDs, including acetylsalicylic acid.

Panadol tablets are not prescribed for the following diseases and pathological conditions:

functional;
hyperbilirubinemia (benign);
pathologies of the organs of the hematopoietic system.

Young patients from 6 to 9 years old are given 250 mg(half a tablet) 3 or 4 times a day according to indications. Acceptable daily dosage– 2 years

Children from 9 to 12 years old can take 1 tablet. up to 4 times a day(maximum daily dose– 4 g).

A single dose for patients over 12 years of age is 500-1000 mg, i.e. 1-2 tablets; frequency of administration – up to 4 times a day, observing 4-hour intervals.

As an analgesic, Panadol can be taken for no more than 5 days in a row, but in order to reduce high temperature– no more than 3 days. If there is a need for more long treatment, you should definitely consult a therapist. Taking paracetamol for more than 1 week requires monitoring of peripheral blood and liver function.

Pharmacological action

Paracetamol nonselectively blocks the enzyme cyclooxygenase in the central nervous system, thereby inhibiting the biosynthesis of prostaglandins (pain mediators). The substance reduces the excitability of the hypothalamic thermoregulation center, which causes an antipyretic effect. The anti-inflammatory effect of this active component is poorly expressed, so Panadol almost does not reduce swelling and exudation.

After oral administration, paracetamol is very quickly absorbed from the gastrointestinal tract and is almost evenly distributed in tissues and biological fluids. Biotransformation with the formation of inactive metabolites occurs in the liver, and excretion occurs mainly through the kidneys.

Possible side effects

The vast majority of patients tolerate Panadol tablets well., if the prescribed dosages are followed. The exception is for persons with hypersensitivity to paracetamol or auxiliary ingredients. They may develop skin allergic reaction(itching and erythematous-type rashes), and bronchospasm. In severe cases it is not excluded.

Probable side effects:

With long-term uncontrolled treatment with high doses, the development of tubular necrosis and interstitial nephritis is possible. Hematopoietic function may suffer; peripheral blood analysis shows leukopenia and thrombocytopenia.

Overdose, poisoning with Panadol tablets

For an adult in the absence of liver pathologies, paracetamol poses a danger if 10 g or more is taken per day.

Acute symptoms develop 6-14 hours after accidentally exceeding the dose (≥ 10 g), and chronic symptoms develop after 2-4 days.

Clinical signs acute overdose:

(excessive sweating);
anorexia ( sharp decline or complete absence appetite);
intestinal disorders;
pain or discomfort in the abdominal area.

Symptoms of chronic overdose:

decreased physical activity;
severe general weakness;

Overdose can lead to such severe complications, such as hepatonecrosis, progressive encephalopathy (against the background of liver dysfunction), collapsed state and coma. If qualified medical assistance is not provided in a timely manner, paracetamol poisoning can be fatal for the patient.

In case of overdose, you need to call an ambulance, rinse the victim’s stomach and give it (regular or white). The specific antidote for paracetamol is methionine; it must be administered within 8-9 hours after poisoning. After 12 hours they do intravenous injections N-acetylcysteine for detoxification. Hemodialysis may be required to cleanse the blood. Severe poisoning is an absolute indication for hospitalization of the victim in a specialized hospital department.

Interaction of Panadol with other drugs

With a slight overdose (≥ 5 g) may develop severe intoxication, when taken in parallel barbiturates, tricyclic Rifampicin or WITHZidovudine.

In combination with Panadol tablets antipsychotic and antiparkinsonian drugs(in particular, Carbamazepine) often cause dysuria.

Paracetamol potentiates the effect indirect anticoagulants (Warfarin and other coumarins) and antiplatelet agents; in such situations, the risk of bleeding of various locations (mainly in the gastrointestinal tract) increases.

Other drugs should not be used simultaneously with Panadol. NSAIDs(especially those containing paracetamol) to avoid the development of nephropathy (up to end-stage renal failure).

Antiemetics(Domperidone and Metoclopramide) increase the rate of absorption of paracetamol, and Cholestyramine reduces it.

The concentration of the active component in plasma increases by one and a half times if the patient receives Diflunisal.

Paracetamol reduces the therapeutic effect uricosuric agents.

Panadol tablets during pregnancy and lactation

The studies did not reveal the embryotoxic, mutagenic and teratogenic effects of paracetamol, but V gestation period and breastfeeding Panadol can be administered to a child only after prior consultation with the attending physician. Particular care should be taken when early stages pregnancy (first trimester) and last weeks before childbirth.

If it is necessary to carry out symptomatic therapy during lactation, the question of temporarily transferring the baby to artificial milk formula is raised.

Additionally

During therapy you should refrain from taking alcoholic drinks and pharmacy alcohol tinctures , since ethanol significantly increases hepatotoxicity and provokes inflammation of the pancreas.

One of the possible side effects is dizziness, so it is advisable for patients taking Panadol tablets to temporarily stop taking the medication. vehicles and working with other potentially dangerous machinery.

Conditions for storage and release from pharmacies

You do not need a doctor's prescription to purchase Panadol.

Regular and dispersible tablets should be kept in areas with low level humidity, at a temperature not exceeding +25°C.

The shelf life of Panadol tablets is 5 years from the date of issue.

Keep away from children!

Analogs of Panadol tablets

Analogues of Panadol tablets active substance are the drugs, Strimol and.

Plisov Vladimir, doctor, medical observer

In this medical article you can familiarize yourself with the drug Panadol. The instructions for use will explain in what cases you can take syrup, suppositories or tablets, what the medicine helps with, what are the indications for use, contraindications and side effects. The annotation presents the forms of release of the drug and its composition.

In the article, doctors and consumers can only leave real reviews about Panadol, from which you can find out whether the medicine helped in the treatment of various pains and fevers in adults and children, for which it is also prescribed. The instructions list analogues of Panadol, prices of the drug in pharmacies, as well as its use during pregnancy.

A medicine belonging to the group of non-steroidal anti-inflammatory drugs is Panadol. The instructions for use indicate that 500 mg tablets, Extra with caffeine, suspension or syrup for children Baby, rectal suppositories are prescribed to reduce elevated temperature bodies. Besides this remedy has an analgesic effect.

Release form and composition

Panadol is available in the following dosage forms:

The tablets have white, capsule-shaped with flat edges and a smooth surface. They are coated with enteric film-coated. The main active ingredient of the drug is paracetamol, its content in one tablet is 500 mg.
Panadol Extra tablets.
Oral suspension Children's Panadol Baby (sometimes mistakenly called syrup).
Rectal suppositories 125 mg and 250 mg (for children).

Paracetamol + caffeine + excipients - composition of Panadol Extra.

Suppositories and syrup for children contain only paracetamol.

Pharmacological action

Paracetamol is the main active substance included in the drug. This drug prevents the formation of inflammatory mediators, including chemical compounds and prostaglandins, which provoke an increase in body temperature.

Panadol and other paracetamol-containing drugs are characterized by weak anti-inflammatory activity. This is due to the fact that when paracetamol enters the tissue, cellular enzymes begin to destroy it. The drug has an antipyretic and analgesic effect at the level of the central nervous system. The maximum concentration of the drug in the blood is achieved after 0.5 - 2 hours from the moment of administration.

Paracetamol is broken down in the liver. The drug is eliminated through the kidneys. This product does not disturb the balance of electrolytes and does not have a detrimental effect on the mucous membrane digestive tract, and also does not contribute to fluid retention in the body.

Indications for use

What does Panadol help with? The drug is used for symptomatic therapy and relief pain syndrome:

toothache;
post-traumatic pain;
migraine;
algodismenorrhea;
headaches;
sore throat;
pain from burns;
painful menstruation;
muscle pain;
pain in the back, lower back.

As an antipyretic (febrile syndrome), the drug is prescribed for elevated body temperature (cold, flu, infection). The drug does not affect the progression and course of the underlying disease and is used only to reduce the severity of pain symptoms.

Instructions for use

Panadol film-coated tablets should be swallowed without chewing and with plenty of water. Effervescent tablets must be dissolved in 200 ml of water.

Adults and children over 12 years of age are prescribed 500 mg-1 g (1-2 tablets) up to 4 times a day, if necessary. The interval between doses is at least 4 hours, single dose(2 tablets) can be taken no more than 4 times (8 tablets) within 24 hours.
Children aged 6-9 years: 1/2 tablet. 3-4 times/day. The interval between doses is at least 4 hours. The maximum single dose for children 6-9 years old is 1/2 tablet. (250 mg), maximum daily dose - 2 tablets. (1 g).
Children aged 9-12 years: 1 tablet. up to 4 times/day. The interval between doses is at least 4 hours, a single dose (1 tablet) can be taken no more than 4 times (4 tablets) within 24 hours.

An interval of four hours must be maintained between each use of Panadol. In accordance with the instructions, this product can be taken independently for no more than three days. If after three days of treatment there is no improvement in the condition, you should consult a doctor.

Extra

Adults (including the elderly) and children over 12 years of age are prescribed 1-2 tablets 3-4 times a day, if necessary. The interval between doses is at least 4 hours. The maximum single dose is 2 tablets, the maximum daily dose is 8 tablets.

It is not recommended to use the drug for more than five days as an analgesic and for more than three days as an antipyretic without a doctor’s prescription and supervision. Increasing the daily dose of the drug or the duration of treatment is possible only under the supervision of a physician.

Rectal suppositories

Rectally, in adults and adolescents weighing more than 60 kg, it is used in a single dose of 500 mg, the frequency of administration is up to 4 times a day. Maximum duration treatment - 5-7 days. Maximum doses: single - 1 g, daily - 4 g.

Single oral doses for children aged 6-12 years - 250-500 mg, 1-5 years - 120-250 mg, from 3 months to 1 year - 60-120 mg, up to 3 months - 10 mg/kg.
Single doses at rectal use in children aged 6-12 years - 250-500 mg, 1-5 years - 125-250 mg. Frequency of application - 4 times a day with an interval of at least 4 hours.

The maximum duration of treatment is 3 days. Maximum dose: 4 single doses per day.

Suspension or syrup

The drug is taken orally. The contents of the bottle should be shaken well before use. The measuring syringe placed inside the package allows you to dose the drug correctly and rationally. The dose of the drug depends on the age and body weight of the child.

For children over 3 months of age, the drug is prescribed 15 mg/kg body weight 3-4 times a day, the maximum daily dose is no more than 60 mg/kg body weight. If necessary, you can take the drug every 4-6 hours in a single dose (15 mg/kg), but no more than 4 times within 24 hours. Do not exceed the recommended dose.

Duration of use without consulting a doctor: to reduce temperature - no more than 3 days, to reduce pain - no more than 5 days. In the future, as well as in the absence of a therapeutic effect, you should consult a doctor.

Read also: how to take a close analogue for fever for children and adults.

Contraindications

Absolute:

Increased sensitivity to the components of the drug.
Age up to 6 years.

Relative (prescribing Panadol requires caution in the presence of the following conditions/diseases):

Glucose-6-phosphate dehydrogenase deficiency.
Liver and kidney failure.
Benign hyperbilirubinemia (including Gilbert's syndrome).
Viral hepatitis.
The period of pregnancy and breastfeeding.
Old age.
Alcoholic liver damage and alcoholism.

Side effects

Allergic reactions - skin rash and itching, angioedema Quincke's disease (severe swelling of the soft tissues of the face and external genitalia).
Urinary system - interstitial nephritis(inflammation of kidney tissue), nonspecific bacteriuria (the appearance of bacteria in the urine), renal colic(severe spasm of the kidney tubules with the appearance of severe paroxysmal pain in the lumbar region), papillary necrosis(death of the kidney papillae).
Blood and red bone marrow– a decrease in the number of red blood cells (anemia) and platelets (thrombocytopenia) in the blood, an increase in the concentration of the oxidized form of hemoglobin methemoglobin in the blood (methemoglobinemia).

If signs of side effects appear, you should stop taking Panadol tablets and consult a doctor.

Children, pregnancy and breastfeeding

When used during pregnancy, the active ingredients of the drug penetrate the placental barrier. For this reason, the use of Panadol during pregnancy is not recommended. The drug is prescribed during pregnancy only if the potential risk to the fetus is lower than the benefit to the health of the mother.

In childhood

Contraindication: childhood up to 6 years old.

Special instructions

When prescribing a long course in high doses blood picture should be monitored. Panadol is prescribed only under medical supervision and with caution for kidney or liver diseases, simultaneously with antiemetic drugs (metoclopramide, domperidone), as well as with drugs that lower blood cholesterol (cholestyramine).

To avoid toxic liver damage, you should not combine the use of Panadol and alcoholic beverages. In cases where there is a need for daily painkillers, paracetamol, when used in combination with anticoagulants, can be taken only occasionally. The doctor must be warned about taking Panadol in cases of testing to determine glucose levels and uric acid in the blood.

Drug interactions

The risk of hepatotoxic damage increases with simultaneous treatment with microsomal inducers. liver enzymes and drugs that exhibit hepatotoxic effects. A moderate or slight increase in prothrombin time is recorded.

The absorption of Paracetamol is reduced when anticholinergic medications are prescribed. The severity of the analgesic effect is reduced, and elimination is accelerated when treated with oral contraceptives. Paracetamol inhibits the activity of uricosuric drugs. The bioavailability of Panadol decreases when taken Activated carbon. A decrease in the excretion of Diazepam is recorded.

Panadol accelerates the elimination of Lamotrigine. Metoclopramide increases the concentration of Paracetamol in the blood, increasing its absorption. Probenecid reduces the clearance of Panadol. The opposite effect observed in relation to Sulfinpyrazone and Rifampicin. Ethinyl estradiol enhances the absorption of the drug from the intestinal lumen.

Analogues of the drug Panadol

Analogues are determined by structure:

Sanidol.
Tylenol for babies.
Children's Tylenol.
Panadol Junior.
Xumapar.
Ifimol.
Tsefekon D.
Children's Panadol.
Calpol.
Paracetamol for children.
Daleron.
Tylenol.
Paracetamol.
Febricet.
Passed for children.
Paracetamol syrup 2.4%.
Meksalen.
Apap.
Strimol.
Lupocet.
Paracetamol (Acetophene).
Perfalgan.
Passer
Aldolor.
Pamol.
Panadol tablets soluble.
Akamol Teva.
Efferalgan.
Acetaminophen.

Vacation conditions and price

The average cost of Panadol (tablets 500 mg No. 12) in Moscow is 49 rubles. The price of the suspension is 98 rubles per 100 ml. Available without a prescription.

Store out of the reach of children at a temperature not exceeding 25 C. Shelf life - 5 years.

In this article you can find instructions for use medicinal product Panadol. Feedback from site visitors - consumers - is presented of this medicine, as well as the opinions of specialist doctors on the use of Panadol in their practice. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Panadol, if available structural analogues. Use for the treatment of various pains and fever in adults, children, as well as during pregnancy and breastfeeding. Composition of the drug.

Panadol- analgesic-antipyretic. Has an analgesic and antipyretic effect. Panadol Extra contains paracetamol or a combination of two active ingredients: paracetamol and caffeine.

Paracetamol blocks COX in the central nervous system, affecting the centers of pain and thermoregulation (in inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on COX), which explains the almost complete absence of anti-inflammatory effect. The lack of influence on the synthesis of prostaglandins in peripheral tissues determines the absence of negative influence on water-salt metabolism(sodium and water retention) and gastrointestinal mucosa.

Caffeine stimulates the psychomotor centers of the brain, has an analeptic effect, enhances the effect of analgesics, eliminates drowsiness and fatigue, and increases physical and mental performance.

Compound

Paracetamol + excipients.

Paracetamol + caffeine + excipients (Panadol Extra).

Suppositories and syrup for children contain only paracetamol.

Pharmacokinetics

Absorption is high. Panadol is quickly and almost completely absorbed from the gastrointestinal tract. The distribution of paracetamol in body fluids is relatively even. Metabolized primarily in the liver with the formation of several metabolites. In newborns in the first two days of life and in children 3-10 years of age, the main metabolite of paracetamol is paracetamol sulfate; in children 12 years of age and older, it is conjugated glucuronide. When taking therapeutic doses 90-100% dose taken excreted in urine within one day. The main amount of the drug is released after conjugation in the liver. No more than 3% of the received dose of paracetamol is excreted unchanged.

Indications

headache;
migraine;
toothache;
lower back pain;
neuralgia;
muscle and rheumatic pain;
painful menstruation;
symptomatic treatment of colds and flu (to reduce elevated body temperature);
to reduce elevated body temperature against the background of colds, flu and children's infectious diseases(incl. chicken pox, mumps, measles, rubella, scarlet fever);
for toothache (including teething), headache, ear pain for otitis media and sore throat.

Release forms

Film-coated tablets 500 mg.

Panadol Extra tablets.

Oral suspension Children's Panadol Baby (sometimes mistakenly called syrup).

Rectal suppositories 125 mg and 250 mg (for children).

Instructions for use and dosage

Pills

For adults (including the elderly), the drug is prescribed 500 mg-1 g (1-2 tablets) up to 4 times a day, if necessary. The interval between doses is at least 4 hours, a single dose (2 tablets) can be taken no more than 4 times (8 tablets) within 24 hours.

Children aged 6-9 years are prescribed 1/2 tablet 3-4 times a day, if necessary. The interval between doses is at least 4 hours. The maximum single dose for children 6-9 years old is 1/2 tablet (250 mg), the maximum daily dose is 2 tablets (1 g).

Children aged 9-12 years are prescribed 1 tablet up to 4 times a day, if necessary. The interval between doses is at least 4 hours, a single dose (1 tablet) can be taken no more than 4 times (4 tablets) within 24 hours.

The drug is not recommended for use for more than 5 days as an analgesic and for more than 3 days as an antipyretic without a doctor’s prescription and supervision. Increasing the daily dose of the drug or the duration of treatment is possible only under the supervision of a physician.

Extra

Increasing the daily dose of the drug or the duration of treatment is possible only under the supervision of a physician.

Suspension or syrup

The drug is taken orally. The contents of the bottle should be shaken well before use. The measuring syringe placed inside the package allows you to dose the drug correctly and rationally.

The dose of the drug depends on the age and body weight of the child.

Duration of use without consulting a doctor: to reduce temperature - no more than 3 days, to reduce pain - no more than 5 days.

In the future, as well as in the absence of a therapeutic effect, you should consult a doctor.

Rectal suppositories

Orally or rectally in adults and adolescents weighing more than 60 kg, use a single dose of 500 mg, frequency of administration - up to 4 times a day. The maximum duration of treatment is 5-7 days.

Maximum doses: single - 1 g, daily - 4 g.

Single oral doses for children aged 6-12 years - 250-500 mg, 1-5 years - 120-250 mg, from 3 months to 1 year - 60-120 mg, up to 3 months - 10 mg/kg. Single doses for rectal use in children aged 6-12 years - 250-500 mg, 1-5 years - 125-250 mg.

The frequency of use is 4 times a day with an interval of at least 4 hours. The maximum duration of treatment is 3 days.

Maximum dose: 4 single doses per day.

Side effect

skin rashes;
Quincke's edema;
leukopenia, thrombocytopenia, methemoglobinemia, agranulocytosis, hemolytic anemia;
dyspeptic disorders (including nausea, epigastric pain);
sleep disturbance;
tachycardia.

Contraindications

severe liver dysfunction;
severe renal dysfunction;
arterial hypertension;
glaucoma;
sleep disorders;
epilepsy;
neonatal period;
children under 12 years of age (for Panadol Extra);
hypersensitivity to the components of the drug.

Use during pregnancy and breastfeeding

The drug should be used with caution during pregnancy and lactation.

Special instructions

In cases of long-term use in high doses, monitoring of the blood picture is necessary.

To avoid toxic liver damage, paracetamol should not be combined with alcoholic beverages, or taken by persons prone to chronic alcohol consumption.

In patients suffering from atonic bronchial asthma, hay fever, available increased risk development of allergic reactions.

May change the results of doping control tests for athletes.

Drug interactions

When taken for a long time, the drug enhances the effect of indirect anticoagulants (warfarin and other coumarins), which increases the risk of bleeding.

The drug enhances the effect of MAO inhibitors.

Barbiturates, phenytoin, ethanol (alcohol), rifampicin, phenylbutazone, tricyclic antidepressants and other stimulants of microsomal oxidation increase the production of hydroxylated active metabolites, causing the possibility of severe intoxication with small overdoses.

Microsomal oxidation inhibitors (cimetidine) reduce the risk of hepatotoxicity.

Under the influence of paracetamol, the elimination time of chloramphenicol increases by 5 times.

Caffeine accelerates the absorption of ergotamine.

The simultaneous use of paracetamol and alcoholic beverages increases the risk of developing hepatotoxic effects and acute pancreatitis.

Metoclopramide and domperidone increase, and cholestyramine reduces the rate of absorption of paracetamol.

The drug may reduce the effectiveness of uricosuric drugs.

Analogues of the drug Panadol

Structural analogues of the active substance:

Akamol Teva;
Aldolor;
Apap;
Acetaminophen;
Daleron;
Children's Panadol;
Children's Tylenol;
Ifimol;
Calpol;
Xumapar;
Lupocet;
Mexalen;
Pamol;
Panadol Junior;
Panadol tablets, soluble;
Paracetamol;
Paracetamol (Acetophene);
Paracetamol for children;
Paracetamol syrup 2.4%;
Perfalgan;
Passer;
Children's walker;
Sanidol;
Strimol;
Tylenol;
Tylenol for babies;
Febricet;
Cefekon D;
Efferalgan.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.

Each tablet contains 500 mg paracetamol.

Excipients: pregelatized starch, corn starch, povidone, potassium sorbate, talc, stearic acid, water, hydroxypropyl methyl cellulose, triacetin.

Description

White capsule-shaped tablets with a flat edge. On one side of the tablet there is PANADOL embossed, on the other side there is a mark.

Pharmacological action

Pharmacotherapeutic group: analgesic non-narcotic drug.

ATX code: N02BE01.

Pharmacological properties: The drug has analgesic and antipyretic properties. Blocks cyclooxygenase in the central nervous system, affecting the centers of pain and thermoregulation. The anti-inflammatory effect is practically absent. Does not cause irritation to the mucous membranes of the stomach and intestines. It has no effect on water-salt metabolism, since it does not affect the synthesis of prostaglandins in peripheral tissues.

Indications for use

1. Pain syndrome. For headaches, migraines, toothaches, sore throats, lower back pain, muscle pain, painful menstruation.

2. Feverish syndrome as an antipyretic. At elevated temperatures due to colds and flu.

Contraindications

Hypersensitivity to paracetamol or any other ingredient of the drug;

Severe liver or kidney dysfunction;

Contraindicated in children under 9 years of age and weighing less than 35 kilograms.

Directions for use and doses

Adults (including the elderly): 0.5 - 1 g (1-2 tablets) up to 4 times a day, if necessary. The interval between doses is at least 4 hours, a single dose (2 tablets) can be taken no more than 4 times (8 tablets) within 24 hours.

Children (9-12 years old): 1 tablet up to 4 times a day, if necessary. The interval between doses is at least 4 hours, a single dose (1 tablet) can be taken no more than 4 times (4 tablets) within 24 hours.

Do not exceed the indicated dose. In case of overdose, consult a doctor immediately, even if you feel well.

Side effect

At recommended doses, the drug is usually well tolerated. Paracetamol rarely causes side effects. Sometimes an allergic reaction may occur in the form of skin rashes, itching, and Quincke's edema. Rarely - blood system disorders (anemia, thrombocytopenia, methemoglobinemia).

At long-term use in high doses, the likelihood of liver and kidney dysfunction increases (renal colic, nonspecific bacteriuria, interstitial nephritis, papillary necrosis) and monitoring of the blood picture is necessary. Whenever unusual symptoms you should consult a doctor.

Overdose

Signs acute poisoning paracetamol are nausea, vomiting, stomach pain, sweating, pallor skin. After 1-2 days, signs of liver damage are determined (pain in the liver area, increased activity of “liver” enzymes). In severe cases it develops liver failure, encephalopathy and coma.

Treatment: Stop using the drug and consult a doctor immediately.

In case of accidental overdose, seek medical advice immediately medical care, even if you feel well.

Interaction with other drugs

Interaction with other drugs: the drug, when taken for a long time, enhances the effect of indirect anticoagulants (warfarin and other coumarins), which increases the risk of bleeding. Inducers of microsomal oxidation enzymes in the liver (barbiturates, diphenin, carbamazepine, rifampicin, zidovudine, phenytoin, ethanol, flumecinol, phenylbutazone and tricyclic antidepressants) increase the risk of hepatotoxicity in overdoses. Microsomal oxidation inhibitors (cimetidine) reduce the risk of hepatotoxicity.

Metoclopramide and domperidone increase, and cholestyramine reduces the rate of absorption of paracetamol. Ethanol contributes to the development of acute pancreatitis. The drug may reduce the activity of uricosuric drugs.

Features of application

Before taking the drug, you should consult your doctor if:

you have liver or kidney disease;

You are taking anti-nausea and vomiting medications (metoclopramide, domperidone), as well as medications that lower blood cholesterol (cholestyramine);

Panadol

Compound

1 film-coated tablet Panadol contains:
Paracetamol – 500 mg;
Excipients.

1 film-coated tablet Panadol Active contains:
Paracetamol – 500 mg;
Excipients, including sodium bicarbonate.

1 tablet soluble Panadol Soluble contains:
Paracetamol – 500 mg;
Excipients.

Pharmacological action

Panadol is a drug from the group of non-selective non-steroidal anti-inflammatory drugs. The drug contains the active substance paracetamol, which has a pronounced antipyretic and analgesic effect. The mechanism of action of the drug is associated with inhibition of prostaglandin synthesis, which occurs due to a decrease in the activity of the enzyme cyclooxygenase. The anti-inflammatory effect of the drug is weak due to the fact that paracetamol is inactivated by cellular peroxidases. The analgesic and antipyretic effect of the drug is achieved by reducing the amount of prostaglandins in the central nervous system.

In addition to paracetamol, the drug Panadol Active contains sodium bicarbonate, which helps accelerate absorption active substance and ensures the rapid onset of the therapeutic effect of paracetamol.
After oral administration paracetamol is well absorbed from the gastrointestinal tract, the maximum plasma concentration of the active substance is observed 30-120 minutes after taking the drug. The degree of binding of paracetamol to plasma proteins is low. Metabolized mainly in the liver, excreted by the kidneys in the form of metabolites. The half-life is 2-3 hours.

Indications for use

The drug is used to relieve pain of various etiologies, including:
Headache, migraine and migraine-like pain.
Myalgia, arthralgia, rheumatic pain, neuralgia.
Algomenorrhea, toothache.
In addition, the drug can be used to relieve flu symptoms, including fever, headache and muscle pain.

Directions for use

The drug is taken orally. It is recommended to swallow Panadol and Panadol Active tablets whole, without chewing or crushing, with a sufficient amount of water. Panadol Soluble tablets should be dissolved in a glass of water before taking. The duration of the course of treatment and the dose of the drug are determined by the attending physician individually for each patient.
Adults and adolescents over the age of 12 years are usually prescribed 500-1000 mg of the drug 3-4 times a day. It is recommended to maintain an interval between taking the drug of at least 4 hours.
Children aged 6 to 12 years are usually prescribed 250-500 mg of the drug 3-4 times a day. It is recommended to maintain an interval between taking the drug of at least 4 hours.
The maximum daily dose for adults is 4000 mg, for children aged 6 to 12 years - 2000 mg. If it is necessary to use the drug for more than 3 days in a row, you should consult your doctor. It is not recommended to take the drug for more than 7 days in a row.
Patients suffering from impaired liver and/or kidney function require dose adjustment of the drug.

Side effects

The drug is usually well tolerated by patients, but in some cases the following side effects may develop:
From the outside gastrointestinal tract and liver: nausea, vomiting, pain in the epigastric region, increased activity of liver enzymes.
From the hematopoietic system: anemia, including hemolytic anemia, agranulocytosis, thrombocytopenia, pancytopenia. In addition, methemoglobinemia may develop, the symptoms of which are cyanosis, shortness of breath and cardialgia.
Allergic reactions: skin rash, itching, urticaria, multiforme exudative erythema, toxic epidermal necrolysis and anaphylactoid reactions.
Others: decreased blood glucose levels up to hypoglycemic coma, bronchospasm (occurring mainly in patients with increased individual sensitivity to non-steroidal anti-inflammatory drugs), papillary necrosis and interstitial nephritis. Paracetamol may change laboratory parameters blood sugar and uric acid levels.

Contraindications

Increased individual sensitivity to the components of the drug.
Hyperbillirubinemia, glucose-6-phosphate dehydrogenase deficiency.
Severe liver and/or kidney dysfunction.
Disorders of the hematopoietic system, including anemia and leukopenia.
The drug Panadol and Panadol Soluble are not used to treat children under 6 years of age.
Panadol Active is not used to treat children under 12 years of age.
The drug should not be prescribed to patients suffering from alcoholism.
The drug should be prescribed with caution to patients with liver and/or kidney disease.

Pregnancy

The drug does not have embryotoxic, mutagenic or teratogenic effects, however, due to the fact that paracetamol penetrates the hematoplacental barrier, its administration during pregnancy is possible only if the expected benefit to the mother is higher than the potential risks to the fetus.
The drug can be prescribed during lactation by the attending physician, who must take into account possible risks for a child.

Drug interactions

When used in combination, the drug enhances therapeutic effect coumarin anticoagulants, including warfarin.
When used simultaneously, metoclopramide and domperidone increase the absorption of paracetamol.
Cholestyramine, when used in combination, reduces the absorption of paracetamol.
With simultaneous use of the drug with barbiturates, a decrease in the antipyretic effect of paracetamol is observed.
Inducers of microsomal oxidation, isoniazid and hepatotoxic medicines increase the hepatotoxic effect of paracetamol.
When used simultaneously, the drug reduces the effectiveness of diuretics.
The combined use of the drug with ethanol is contraindicated.

Overdose

When using the drug in doses significantly higher than recommended, patients may develop toxic lesions liver. In addition, on the first day after an overdose of the drug, patients may develop nausea, vomiting, pale skin, loss of appetite and abdominal pain. With a further increase in dose, metabolic acidosis and disorders may develop. carbohydrate metabolism. In case of severe intoxication with the drug, the development of encephalopathy, bleeding, hypoglycemia and coma is possible.
In case of overdose, gastric lavage and use of enterosorbents are indicated. A specific antidote is N-acetylcysteine, which is used during the first 24 hours after taking excessive doses of the drug. If the patient does not develop vomiting, in case of overdose, oral methionine is prescribed. Treatment of an overdose of paracetamol should be carried out under strict medical supervision in a hospital setting.

Official instructions for the drug Panadol.

Attention!
Description of the drug " Panadol"on this page is a simplified and expanded version of the official instructions for use. Before purchasing or using the drug, you should consult your doctor and read the instructions approved by the manufacturer.
Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.