The best B vitamin complexes. Description of pharmacological action. Medicines containing cyanocobalamin

Characteristic

B-Complex provides good nutritional support to the nervous system. If all the B vitamins are present in your body at the same time, they interact with each other and contribute to energy production. They are important for your nerves, skin, hair, eyes and liver, necessary for normal fat and protein metabolism and maintaining muscle tone gastrointestinal tract.

Vitamin complexBin tablets It is more expedient to take than to try to organize a diet that includes a variety of vegetables, fruits, and meat. It is impossible to eat enough food to normalize and replenish required quantity vitamins of this group. Group B includes correct proportions para-aminobenzoic acid, riboflavin, nicotinic acid, thiamine, choline, inositol, pyridoxine, biotin, folic acid, cyanocobalamin and pantothenic acid. This corresponds to designations B1 to B 12.

Indications:

Diseases nervous system, frequent or chronic emotional stress
Pathologies of the gastrointestinal tract

Action of B-Complex:

Replenishes deficiency of B vitamins in the body
Helps strengthen the nervous system
Increases resistance to stress, depression, fatigue
Provides support cardiovascular system
Beneficial effect on the liver, intestines, organs of vision, skin and hair

Directions for use and dosage:

As a dietary supplement, take 1-2 tablets daily with meals.

Contraindications:

Individual intolerance to any component included in the product.

Storage:

In a cool (at a temperature not exceeding +25°C) and dry place.

Release form:

Tablets (60 tablets in a jar).

Composition (1 tablet):

Vitamin B1 (thiamine) 4.5 mg
Vitamin B2 (riboflavin) 6 mg
Vitamin B3 (niacinamide) 60 mg
Vitamin B5 (calcium pantothenate) 20 mg
Vitamin B6 (pyridoxine HCl) 6 mg
Vitamin B12 (cyanocobalamin) 9 mcg
Folic acid 400 mcg
Biotin 50 mcg
Choline 150 mg
Para-Aminobenzoic acid (PABA) 50 mg
Inositol 150 mg

Description of components:

B vitamins are one of the the most important groups nutrients. These vitamins are closely related, which has given rise to a group that is often called the B-Complex.

Vitamin B1 (thiamine)- one of the essential factors in the metabolism of fats, proteins and carbohydrates. It normalizes the functioning of the nervous and cardiovascular systems, regulates acidity gastric juice, motor function stomach and intestines.

Vitamin B2 (riboflavin) participates in the utilization of fats, proteins and carbohydrates, it is indispensable in the growth processes of the body. Vitamin B2 regulates the state of the central and peripheral nervous system, has positive impact on vision.

Vitamin B3 (niacin) participates in energy production processes, in the formation of a number of enzymes, normalizes carbohydrate, protein metabolism, renders positive influence improves the functioning of the digestive, nervous systems, heart, and improves immunity. Vitamin B3 helps reduce cholesterol levels and affects the synthesis of sex hormones, cortisone, thyroxine, and insulin. It helps saturate brain cells with Oxygen, increasing the efficiency of its work.

Vitamin B6 (pyridoxine) participates in the synthesis of nucleic acids, regulates phosphorus-calcium metabolism, improves liver function, participates in hematopoiesis, reduces blood sugar levels, strengthens the immune system. He's playing important role in the production of neurochemicals responsible for good mood. With a deficiency of this vitamin, disorders of the nervous system and depression are observed.

Vitamin B12 (cyanocobalamin) normalizes hematopoietic processes, the functioning of the liver and nervous system, regulates the metabolism of proteins, fats and carbohydrates.

Folic acid participates in the synthesis of nucleic acids, hematopoiesis, and prevents malformations of the neural tube in the fetus.

Biotype necessary for synthesis ascorbic acid, digestive enzymes. He participates in work enzyme systems, helps maintain healthy condition skin and hair.

Pantothenic acid(calcium pantothenate, vitamin B5) is necessary for the metabolism of proteins, fats and carbohydrates, regulates the state of the central and peripheral nervous system, the functioning of the adrenal glands, takes part in the synthesis of hemoglobin and antibodies.

Choline and inositol- two important lipotropic factor- promote the removal of cholesterol, participate in the transmission of nerve impulses.

PABA (para-aminobenzoic acid) participates in the formation of folic acid.

B vitamins play an extremely important role in converting food into energy, in the metabolism of fats, proteins and carbohydrates, and help improve energy production in the body.

B vitamins necessary for normal functioning nervous system and are one of the most important factors, affecting the condition nerve tissue. They normalize the functioning of the cardiovascular system, as well as the liver, stomach and colon, and are necessary to maintain muscle tone in the gastrointestinal tract.

B vitamins are water soluble, the body cannot store them for for a long time, therefore, their quantity must be replenished daily with the help of a properly chosen diet or in the form of a biologically active food supplement.

B-Complex provides the body with all B vitamins at the same time. This dietary supplement is recommended for diseases of the nervous system, frequent or chronic emotional stress, with pathology of the gastrointestinal tract.

Additional information

B vitamins traditionally used to treat various neurological diseases. Clinicians know that deficiency of vitamins B1 (thiamine), B6 (pyridoxine) and B12 (cobalamin) leads to the development of peripheral nerve damage.

Thus, a lack of any of these vitamins will affect the state of the nervous system in one way or another. Considering the fact that B vitamins are often found in complexes in food products, signs of vitamin deficiency are usually observed simultaneously. Since in our time there is practically no absolute deficiency of vitamins, the severity of symptoms may vary. For example, fatigue can go unnoticed for a long time until it begins to interfere with the usual routine of life.

Besides being tired common symptoms There may be irritability, emotional instability, headache, sexual dysfunction, sensory disturbances and trembling of the limbs. And this is far from full list disorders caused by deficiency of B vitamins.

Most vitamins do not circulate in the blood, but are located at the sites of their activity or in depots, so a blood test will not give accurate results. The main method for diagnosing hypovitaminosis remains clinical, that is, based on complaints and individual symptoms. Therefore, to determine a deficiency of B vitamins, you should first pay attention to the state of the nervous system.

Despite the fact that B vitamins take part in almost all metabolic processes, for some reason it is the nervous system that suffers first. This is most likely due to the extremely high intensity of operation of this system.

Manifestations of hypovitaminosis can be different. As a rule, the first symptoms are quite vague and can go unnoticed by the person for a long time. Among them:

increased fatigue
weakness
chronic fatigue and exhaustion
decreased memory and performance
disturbances in cardiac activity (tingling, fading, discomfort).

Naturally, at this stage few people pay attention to such manifestations. Such symptoms can be explained by anything, including helminthiases and pregnancy. Following these symptoms, various neurological disorders, the main ones:

tingling and numbness in the fingers and toes
goosebump sensation
nervousness, irritability
obsessive fears
depression
sleep disorder
sexual dysfunction disorder

Skin lesions often occur in the form of furunculosis or acne. When it comes to expressed neurological symptoms, then this is usually followed by a visit to a neurologist.

Particular attention to this group of vitamins should be paid to people with pathologies of the gastrointestinal tract, especially with malabsorption syndrome, when the absorption of not only basic nutrients, but also vitamins is impaired. It is also known that any disease of the digestive system negatively affects the intestinal microflora, which plays a significant role in the synthesis and absorption of B vitamins.

Increase the content of foods containing B vitamins in your diet. This cereal crops, wholemeal bread, nuts, lactic acid products.
Reduce or eliminate refined sugar from your diet. This product robs our body of B vitamins.
Avoid synthetic products and preservatives.
Stop abusing alcohol, coffee and smoking.
Increase your resistance to stress by regularly physical exercise and rational rest.
Eliminate all possible sources of infection. This can be caries, tonsillitis and any infection, both manifest and hidden. Any infectious process The body uses up vitamin reserves.
Start taking a B complex vitamin.

IN modern society it's already hard to find completely natural products, so you need to be aware of things like B-complex vitamins to ensure you're getting enough beneficial micronutrients. In this article, we will talk about why these particular vitamins are useful, whether we really need them, and also choose the most suitable complex. After all, in modern conditions, taking into account constant stress, poor ecology and lack of time, vitamin deficiency becomes an urgent problem.

Why do you need a vitamin B complex?

We owe the discovery of vitamin B to the Polish scientist Kazemir Funk. In 1912, it was established that vitamins of the group are nitrogenous compounds. Each of these compounds has separate characteristic properties, each of them has its own number. At the same time, all representatives of this group have much in common. To understand why we need these vitamins, let's look at each of them separately.

Vitamin B1 or thiamine is the first of this group to be discovered. It's water soluble chemical compound, which our body needs every day. Main role Thiamine is directly involved in the metabolic process. It also affects the functioning of the brain, endocrine and digestive system. As a rule, Vitamin B1 is prescribed for metabolic disorders and diseases of the cardiovascular system. It is also used for skin diseases and for visual impairment.

Vitamin B2 or riboflavin is responsible for regeneration and helps speed up the wound healing process. This vitamin has a beneficial effect on the condition of the skin and mucous membranes. With its deficiency in the body, peeling of the skin, blurred vision, dizziness and drowsiness may occur. Riboflavin may act as one of the means complex therapy for anemia, eye diseases and gastritis.

Vitamin B3 or niacin is a soluble powder white. This trace element is necessary for the formation of hormones. Nicotinic acid itself is involved in more than half a hundred reactions and performs the function of releasing energy. Vitamin B3 is very important for the normal functioning of the brain. Among its properties, it is noted that it prevents genetic damage, as well as normalizes the functioning of the cardiovascular system.

Vitamin B5 or panthenol - water soluble vitamin, which is involved in the breakdown of fats and carbohydrates. Pantothenic acid affects the production of acetylcholine, which, in turn, helps the nervous system function smoothly. Among other things, panthenol helps with wound healing and is directly involved in the production of red blood cells.

Vitamin B6 regulates heart function, participates in the synthesis of protein and enzymes. Has a beneficial effect on the condition of the skin and hair. With a deficiency of vitamin B6, atherosclerosis develops, immunity decreases, dermatitis and anemia appear. A deficiency of this substance can be indicated by brittle nails and hair loss.

Vitamin B9 or folic acid is necessary for the production of white blood cells and red blood cells. This vitamin plays an important role in normal development fetus, so its use is often prescribed to pregnant women.

Vitamin B12 or cyanocobalamin is a water-soluble vitamin whose main task is hematopoiesis and energy metabolism. In addition, vitamin B12 helps to be better absorbed in the body folic acid. Acute shortage in this trace element can lead to anemia, brain problems and even mental disorders.

As you can see, a lack of vitamins in this group can lead to various consequences, including serious illnesses. We can receive required quantity microelements through food. However, we are unlikely to be able to avoid a deficiency in at least one of the vitamins from this group. It is difficult not only to create a diet rich in all necessary elements, but also to comply with it.

Fortunately, modern pharmacology offers us an alternative - a complex of B vitamins. Pharmacy drugs will certainly help us compensate for the lack of these substances in the body. The difficulty here lies in choosing a complex. There are a huge number of similar vitamin complexes, but it is important to choose the most suitable and most effective one, because we want to get the maximum benefit.

Vitamin B complex – which one is better?

Multivitamin complexes with B vitamins, based on market offers, can be divided into 2 groups:

Combined (contain additional minerals and other groups of vitamins);
Specialized (contain high dosages vitamins B).

Among the combined complexes that contain B vitamins, the following can be distinguished:

AlfaVit Classic;
Supradin;
Vitrum;
Centrum from A to Zinc;
Complivit;
Perfect;
Duovit.

All these drugs can be found on the shelves in pharmacy chains. Each of these complexes contains the entire group of B-vitamins. In Perfectil and Supradin, the dosages for some vitamins from this group are slightly higher than the therapeutic dosage. Thus, they contain approximately 10 times more (compared to other drugs) vitamin B1, 3-4 times more vitamin B2 and 10 times more vitamin B6. The most vitamin B5 is found in Perfectil. The richest in vitamin B12 content is Complivit.

Specialized B vitamin complexes can also be divided into two groups:

Injectable;
Tablets.

The division, as can be seen, is based on their form of implementation. Let's take a closer look at each of them and highlight several drugs.

Injections are usually used in crisis situations when you need to get instant results. This form is used to achieve quick therapeutic effect. The most popular and effective drugs injection form can be called the following:

Tigamma – domestic development with vitamins B1, B6, B12;
Compligam – Russian vitamin complex group B with vitamins B1, B6, B12;
Beviplex - Serbian development with a more impressive composition - B1, B2, B5, B6, B12, PP;
Neurobion is a German manufacturer with three vitamins in a complex - B1, B6, B12

Tablets are usually intended for long-term therapy with a gradual effect. Among the most effective and popular are:

Multi-Tabs B-complex;
Milgamma Compositum;
Doppelhertz;
Neurobion.

The concentration of B vitamins in these supplements is usually increased because they are intended for the complex treatment of diseases of the nervous system and the treatment of vitamin deficiency.

The Multi-Tabs complex contains all the B vitamins mentioned above. If we compare it with other drugs, then in comparison with the products already discussed, it contains increased content:

Vitamin B2 5-8 times;
Vitamin B5 5-6 times;
Vitamin B1 10 times.

At the same time, Multi-Tabs B-complex contains less pantothenic acid and thiamine than Perfectil and Supradin, respectively.

Doppelhertz active Magnesium + B vitamins – famous drug German made. Its main feature is the combination of a classic set of B-complex vitamins and a microelement such as magnesium. You can find vitamins B1, B6, B9 and B12 in it.

Most often this is biologically active supplement recommended for elevated physical activity athletes, in stressful situations, as well as to replenish useful substances with an unbalanced diet.

The combination of group vitamins and magnesium is an excellent combination, making this drug very popular among sprinters. They use it to recover from hard workouts. Also among the fans of this supplement are elderly people, for whom the Doppelherz B vitamin complex becomes one of the means of preventing postoperative complications and diseases of the cardiovascular system.

Neurobion is another representative of Germany on the market of multivitamin complexes. The tablets contain three B vitamins:

Thiamine (B1);
Pyridoxine (B6);
Cyanocobalamin (B12).

The technology used to create the drug allows it to be stored in tablets. biological activity all the components we need. A high dosage of each vitamin from the group helps to compensate for their deficiency in the body even in the most advanced cases.

As a rule, Neurobion is prescribed for complex treatment trigeminal nerve, neuritis and during stressful situations. This complex is excellent for eliminating mild forms of depression, if they are caused precisely by a deficiency of the vitamins in question.

Milgamma Compositum is represented by only two B vitamins – B1 and B6. However distinctive feature This drug is that the manufacturer replaced vitamin B1 with a similar benfotiamine. This analogue is fat-soluble, and therefore is absorbed better than the usual thiamine in the stomach. The dosage of B6 in this drug is significantly higher than all other drugs reviewed.

We have reviewed the most best vitamins B-complex. Each of them has a different concentration of certain representatives of this vitamin group. Assessing your physical and mental health, relying on beneficial properties each vitamin, you can choose the most suitable complex for you. You should not choose the one with the highest dosages. It is best to consult with your doctor, who will make the correct diagnosis and give recommendations on choosing a particular multivitamin complex.

Instructions for use

medicine forspecialists

VITAMIN B complex

Trade name

VITAMIN B complex

International nonproprietary name

Dosage form

Solution for injection 2 ml

Compound

2 ml of solution contains

active substances: thiamine hydrochloride (vitamin B 1) 10 mg,

riboflavin sodium phosphate in the form of 100% ribo -

flavin (vitamin B 2) 2 mg,

pyridoxine hydrochloride (vitamin B 6) 10 mg,

nicotinamide (vitamin PP) 100 mg,

excipients: edetate disodium 1 mg, parahydroxybenzoate

methyl - 2 mg, glycerin - 352 mg, water for injection up to 2 ml.

Description

Clear liquid; color - yellow to yellow-orange; the smell is specific to thiamine hydrochloride.

Farmacotherapy group

B vitamins in combination with other drugs.

ATS code A11EX

Pharmacological properties

Pharmacokinetics

Distribution: Vitamin B1 is distributed in all tissues. About 70-80% of vitamin B6 in the human body is distributed in the muscles, about 10% in the liver, and the rest in other tissues. The concentration of vitamin B 6 in blood plasma averages 6 µmol/100 ml. Pyridoxal phosphate binds completely to plasma proteins. Pyridoxine does not bind to plasma proteins. Riboflavin is distributed evenly in various tissues.

Metabolism: Vitamin B1 is highly metabolized in the liver and its main metabolites are thiamine carboxylic acid and pyramine.

Pyridoxine and priridoxamine are phosphorylated by the enzyme pyridoxal kinase and then transformed into pyridoxal 5-phosphate with the participation of a flavin-dependent enzyme. Free pyridoxal is broken down by alkaline phosphatase, hepatic and renal aldehyde oxidase and pyridoxal dehydrogenase.

Nicotinamide is metabolized to N-methyl-nicotiamide, which is then oxidized to N-methyl-4-pyridone-3-carboxamide. The plasma half-life is approximately 40 minutes.

Excretion: Vitamin B1 is excreted in urine and partly in bile.

Vitamin B2 is excreted unchanged in the urine or in the form of riboflavin-5-phosphate. Its half-life is 14 hours.

Vitamin B 6 is excreted in the urine (almost entirely in the form of metabolites). The half-life is 15-20 days. Eliminated by hemodialysis. Patients undergoing hemodialysis should receive increased quantities(up to 300% of the recommended dose).

Following therapeutic doses of nicotinamide, only small amounts of unchanged nicotinamide are excreted in the urine.

Pharmacodynamics

B vitamins are biologically active in low concentrations and regulate cellular functions. They are part of many enzyme systems and are involved in regulating the metabolism of carbohydrates, proteins, fats and in the synthesis of nucleic acids. The combined use of B vitamins leads to a synergism of their action.

Niamycin and its amides are part of NAD and NADP codehydrases, participating in oxygen transport and redox processes. They are necessary for tissue respiration. Niacin induces peripheral vascular dilatation and reduces plasma cholesterol and triglyceride levels.

Indications for use

Deficiency of B vitamins (B 1, B 2, B 6) and nicotinamide

Neuritis, polyneuritis (alcoholic, toxic, post-infectious)

Diabetic polyneuropathy

Neuralgia, sciatica

Spastic conditions central genesis

Myasthenia gravis

Wernicke's encephalopathy

Autonomic neuroses

Asthenia

Dermatitis

Neurodermatitis

Exudative diathesis

Psoriasis

Erythematous lupus

Furunculosis

Stomatitis

Glossitis

As part of complex therapy:

Atherosclerosis

Chronic alcoholism

Hepatitis

Intoxication syndrome.

Directions for use and doses

The drug is usually administered intramuscularly or rarely intravenously at a dose of 1-2 ml per day or every other day for 5-10 days.

Side effects

The drug is usually well tolerated. May occur very rarely:

Urticaria, itching, angioedema, contact dermatitis

Bronchospasm

Yellow-orange coloration of urine

Renal dysfunction.

Contraindications

Hypersensitivity to the components of the drug

Arterial hypertension II and III degrees

Use with caution when malignant tumors due to possible stimulation of tumor cell proliferation

Pregnancy and lactation

Drug interactions

No data available pharmacological interaction between thiamine, riboflavin, pyridoxine and nicotinic acid.

There is no data on the physicochemical interaction between the individual components of the drug in solution.

Physico-chemical incompatibilities: due to various in vitro incompatibilities, simultaneous use (in the same syringe) with benzylpenicillin and oxacillin (inactivation and precipitation of the antibiotic), macrolides (formation of insoluble precipitate), chloramphenicol (precipitation), vitamin B 12 (destruction of vitamin B 2 by cobalt ions), vitamin C (inactivation of vitamin B 6).

Pharmacodynamic interaction: the drug can reduce the hypotensive effect of adrenergic and sympatholytic drugs, and can suppress the sedative effect of barbiturates and glutethimide due to the presence of vitamin B1. Vitamin B6 reduces the antiparkinsonian effect of levodopa.

Chlorpromazine increases urinary excretion of vitamin B2, probenecid suppresses tubular secretion and reabsorption of vitamin B2, as a result of which its excretion in urine decreases.

Special instructions

Prescribing the drug to patients with a history of: peptic ulcer stomach and duodenum, gastritis, kidney and liver diseases, gout - must be done with caution and under the supervision of a doctor.

Pyridoxine may cause pseudo-positive results when urobilinogen is determined using Ehrlich's reagent.

Use in pediatrics

There is no data on the use of this form of the drug in pediatric practice.

Pregnancy and lactation

Vitamin B 6 is excreted from breast milk Therefore, Vitamin B complex is not recommended during breastfeeding. If necessary, breast-feeding needs to stop.

Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms

Does not affect driving ability vehicles.

Overdose

Symptoms: excitement, fear, tremor, insomnia, headache, convulsions, development of peripheral neuropathy in the form of ataxia.

Treatment symptomatic.

Isoniazid is an antidote to pyridoxine.

Release form and packaging

Solution for injection 2 ml.

Ampoules of 2 ml (I hydrolytic class). Ampoules No. 10 are placed in a blister made of solid PVC foil. One blister is packed in a cardboard box with instructions.

Storage conditions

In the original packaging, in a dry place protected from light at a temperature not exceeding + 25ºС. Do not freeze!

Keep out of the reach of children!

Best before date

Do not consume after expiration date.

Conditions for dispensing from pharmacies

By prescription

Manufacturer

JSC SOPHARMA, Bulgaria

Sofia, st. Ilienskoye Highway No. 16

Vitamin B Complex - a complex of B vitamins.

Indications and dosage

Indications for Vitamin B Complex:

Conditions of deficiency of B vitamins (B 1, B 2, B 6) and nicotinamide in the following diseases:

central and autonomic nervous system: neuritis, polyneuritis (alcoholic, toxic, post-infectious), diabetic polyneuropathy, neuralgia, sciatica, spastic conditions of central origin, myasthenia gravis, Wernicke encephalopathy, autonomic neuroses, asthenia
skin: dermatitis, neurodermatitis, exudative diathesis, psoriasis, lupus erythematosus, furunculosis;
others stomatitis, glossitis, colitis, sprue, atherosclerosis, chronic alcoholism, hepatitis, anemia, intoxication.

The drug is usually prescribed intramuscularly, in more cases in rare cases- intravenously.

Children aged 6 to 12 years - 1 ml per day or every other day.

Children over 12 years old and adults - 1-2 ml per day or every other day.

The course of treatment is 5-10 days.

After completing the course, you can switch to oral treatment with Vitamin Complex, film-coated tablets.

Overdose

Symptoms. The use of high doses of the drug Vitamin B Complex can cause agitation, fear, tremors, insomnia, herpes, headache, and convulsions.

Treatment. Symptomatic treatment is carried out.

Side effects

Side effects of the drug Vitamin B Complex:

Hypersensitivity reactions - urticaria, itching or angioedema, especially in patients with hypersensitivity.

Nicotinamide, which is part of the drug, can cause redness of the facial skin and hot flashes.

Contraindications

Contraindications Vitamin B Complex:

§ sensitivity to any active or excipient;

§ stage II-III hypertensive disease;

§ age up to 6 years.

Interaction with other drugs and alcohol

Chlorpromazine increases the excretion of vitamin B2 in the urine, while probenecid inhibits the tubular secretion of vitamin B2, as a result of which its excretion in the urine slows down, which leads to potentiation of therapeutic and side effects.

Vitamin B1 contained in the drug can both antagonize the hypotensive effect of adrenolytics and suppress sedative and hypnotic effect barbiturates and glutethimide.

Vitamin B1 may enhance the effect of tricyclic antidepressants (nortriptyline, imipramine, desipramine), especially in elderly patients.

Vitamin B 6 has an antagonistic effect on the antiparkinsonian effect of L-Dora.

The simultaneous use of nicotinamide and antiepileptic drugs, especially carbamazepine, diazepam and sodium valproate, potentiates their anticonvulsant effect.

Composition and properties

active ingredients: thiamine hydrochloride (vitamin B 1), riboflavin sodium phosphate (vitamin 2), pyridoxine hydrochloride (vitamin B 6), nicotinamide (vitamin PP)

1 ml thiamine hydrochloride (vitamin 1) 5 mg riboflavin sodium phosphate equivalent to riboflavin (vitamin 2) 1 mg pyridoxine hydrochloride (vitamin 6) 5 mg nicotinamide (vitamin PP) 50 mg

excipients: sodium edetate, methyl parahydroxybenzoate (E 218), glycerin, hydrochloric acid (1 mol / l), water for injection.

Release form: Solution for injection.

Pharmacological action:

Pharmacodynamics.

B vitamins are organic substances with different chemical structure necessary to ensure vital important functions body. They are biologically active in low concentrations and are involved in the regulation of cellular functions. B vitamins are part of many enzyme systems and are involved in the regulation of the metabolism of carbohydrates, proteins and fats, and in the synthesis of nucleic acids. When used simultaneously, vitamins have a stronger and more complex effect. biological effect: combined use B vitamins leads to their synergism.

Vitamin B1, after conversion to pyrophosphate, participates as a coenzyme in the metabolism of carbohydrates, proteins and the synthesis of nucleic acids. Affects the conduction of nerve impulses at synapses.

The physiological effect of riboflavin is determined by its participation in the redox processes of the body. Improves carbohydrate metabolism, has a positive effect on improving lipid metabolism, and is also associated with the synthesis of amino acids. Riboflavin is involved in the metabolism of iron and porphyrins, as well as in the synthesis of hemoglobin and cellular respiration.

Vitamin B 6 is part of enzymes such as decarboxylase and transaminases. Participates in the exchange of free amino acids and proteins. Plays an important role in histamine metabolism. Participates in processes fat metabolism. Necessary for the normal functioning of the central and peripheral nervous system, skin and digestive organs.

Nicotinamide, as the amide of nicotinic acid, is part of the codehydrases NAD and NADP, which are involved in oxygen transport and carry out redox processes necessary for tissue respiration. Nicotinamide causes peripheral vasodilation and reduces plasma cholesterol and triglyceride levels.

Pharmacokinetics.

Distribution. Up to 70-80% dose taken Vitamin B 6 is distributed in the muscles, 10% in the liver, the rest in other tissues. Its normal plasma concentration averages 6 µmol/100 ml.

Pyridoxal phosphate is completely bound to blood plasma proteins. Pyridoxine does not bind to blood plasma proteins.

Riboflavin is distributed evenly in various tissues.

Vitamin B 1 is distributed almost evenly in all tissues

Metabolism. Vitamin B1 is metabolized to a significant extent; its main metabolites are thiamine carboxylic acid and pyramine.

Pyridoxine and pyridoxamine are phosphorylated by the enzyme pyridoxal kinase and then transformed into pyridoxal 5"-phosphate using the flavin enzyme. ALP, hepatic and renal aldehyde oxidases and pyridoxal dehydrogenase participate in the biotransformation of free pyridoxal.

Nicotinamide is metabolized to N-methyl-nicotinamide, which is then oxidized to N-methyl-4-pyridone-3-carboxamide. Its half-life is approximately 40 minutes.

Conclusion. Vitamin B1 is excreted in the urine and partially in the bile, and one part of it is exposed to the enterohepatic circulation. Vitamin B1 is excreted into breast milk. Vitamin B2 is excreted in the urine unchanged and in a small part - in the form of riboflavin-5-phosphate. Inactive metabolites of vitamin 2 are also excreted in the urine. Its half-life is 14 hours.

injection solution: amp. 2 ml 10 pcs.
Reg. No.: 8033/07/12/17/17 dated 12/07/2017 - Registration period. beat not limited

Solution for injection in the form clear liquid yellow-green in color, practically free of particles, with a specific odor of thiamine hydrochloride.

Excipients: disodium edetate, methyl parahydroxybenzoate (E218), glycerol, hydrochloric acid (1 mol/l), water d/i.

2 ml - dark glass ampoules (10) - blisters (1) - cardboard packs.

Description medicinal product VITAMIN B COMPLEX based on officially approved instructions for use of the drug and made in 2013. Update date: 02/15/2013

Pharmacological action

B vitamins are organic substances with different chemical structures that are absolutely essential for vital functions body. They are biologically active in low concentrations and regulate cellular processes. B vitamins are part of a number of enzyme systems and are involved in the metabolism of carbohydrates, proteins and fats, as well as in the synthesis of nucleic acids. By combined administration of B vitamins in the body, synergism of their effects is achieved.

Nicotinamide, as a co-dehydrase of NAD and NADP, is involved in hydrogen transport and in redox processes necessary for tissue respiration. It causes peripheral vasodilation and lowers plasma levels of cholesterol and triglycerides.

Pharmacokinetics

Distribution

Up to 70-80% of the taken dose of vitamin B 6 is distributed in the muscles, up to 10% in the liver, and the rest in other tissues. Its normal plasma concentration averages 6 µmol/100 ml.

Pyridoxal phosphate is completely bound to plasma proteins. Pyridoxine does not bind to plasma proteins. Riboflavin is distributed evenly in various tissues.

Metabolism

Vitamin B 1 is metabolized to a large extent and its main metabolites are thiamine carboxylic acid and pyramine.

Pyridoxine and pyridoxamine are phosphorylated by the enzyme pyridoxal kinase and then transformed to pyridoxal 5'-phosphate using a flavin-dependent enzyme. Alkaline phosphatase, hepatic and renal aldehyde oxidase and pyridoxal dehydrogenase participate in the biotransformation of free pyridoxal.

Nicotinamide is metabolized to N-methyl-nicotinamide, which is oxidized to N-methyl-4-pyridone-3-carboxamide.

Removal

Vitamin B 1 is excreted in the urine and partially in the bile, with one part of it undergoing enterohepatic circulation. Vitamin B1 is also excreted in breast milk.

Vitamin B2 is excreted in the urine unchanged or in the form of riboflavin-5-phosphate. Inactive metabolites of vitamin B2 are also excreted in the urine. T 1/2 is 14 hours.

Vitamin B 6 is excreted in the urine mainly in the form of metabolites. T 1/2 is 15-20 days. Eliminated by hemodialysis. Patients undergoing hemodialysis should receive 100 to 300% of the recommended dose.

When used in therapeutic doses, unchanged nicotinamide is found in the urine in small quantities. T 1/2 is 40 min.

Side effects

The drug is well tolerated.

Very rarely hypersensitivity reactions such as urticaria, itching, angioedema can be observed, especially in predisposed patients.

Nicotinamide, which is part of the Vitamin B complex, can cause redness of the facial skin and hot flashes.

Use during pregnancy and breastfeeding

The drug can be used during pregnancy in therapeutic doses. The use of high doses in utero can cause pyridoxine dependence syndrome in the newborn.

Vitamin B 6 is excreted in breast milk and its concentration depends on the dose taken by the mother. The use of Vitamin B complex in women during lactation is not recommended. If the use of the drug is necessary, breastfeeding should be discontinued.

Special instructions

In case of malignant processes, Vitamin B complex (containing thiamine) should be used with caution due to the possible stimulation of tumor cell proliferation.

Due to the very rare but serious threat of anaphylactic shock(the so-called thiamine shock) before using Vitamin B complex solution for injection, a skin allergy test is recommended.

Excess daily dose pyridoxine (more than 100 mg) for a long time can lead to the manifestation of peripheral polyneuropathy with ataxia and burning pains in the feet. The development of these symptoms may occur 1 month to 3 years after the start of treatment.

When determining urobilinogen using the Ehrlich reagent, pyridoxine can cause a false positive result.

Riboflavin can cause yellow-orange coloration of urine.

The use of nicotinamide in patients with a history of ulcers, gastritis, hemorrhage, gout, liver damage and biliary tract requires special care. It is necessary to monitor the level of transaminases, alkaline phosphatase, GGTP, bilirubin, uric acid, platelets, especially if long-term treatment with Vitamin B complex is required.

The drug contains methyl parahydroxybenzoate (E218) as an excipient, which may cause allergic reactions. Usually these reactions are of a delayed type, such as contact dermatitis. Less commonly, the drug may cause immediate reactions such as urticaria and bronchospasm.

The drug contains less than 1 mmol of sodium (23 mg) per dose, i.e. Contains virtually no sodium.

Impact on the ability to drive vehicles and operate machinery

Vitamin B complex in therapeutic doses does not affect the ability to drive vehicles or operate machines.

Preclinical safety data

The B vitamins included in the combination drug are practically non-toxic.

There is no data on the embryotoxic, teratogenic and mutagenic effects of individual vitamins.

Overdose

Symptoms: very high doses(more than 10 g) Vitamin B complex can cause overdose symptoms (excitement, tremors, fear, insomnia, herpes, headache, convulsions).

Treatment is symptomatic.

Drug interactions

Chlorpromazine increases the excretion of vitamin B2 in the urine, while probenecid suppresses its tubular secretion and slows down its excretion from the body, which leads to potentiation of therapeutic and side effects.

Vitamin B1, which is part of the drug, can antagonize the hypotensive effect of adrenolytics, as well as suppress the sedative and hypnotic effects of barbiturates and glutethimide.

Vitamin B1 may potentiate the effect of tricyclic antidepressants (nortriptyline, imipramine, desipramine), especially in elderly patients.

Vitamin B6 antagonizes the antiparkinsonian effect of levodopa.

With simultaneous use of nicotinamide with antiepileptic drugs, especially such as carbamazepine, diazepam and sodium valproate, their anticonvulsant effect may be potentiated.

Incompatibility

Due to proven in vitro incompatibility, simultaneous use (mixing in one syringe) of Vitamin B complex with the following drugs is not recommended:

benzylpenicillin and oxacillin (inactivation and precipitation of the antibiotic);
macrolides (formation of insoluble precipitate);
chloramphenicol (precipitation);
vitamin B 12 (destruction of vitamin B 12 by cobalt ions);
vitamin C (inactivation of vitamin B 6).