Human antistaphylococcal immunoglobulin. Staphylococcal immunoglobulin. Contraindications and side effects

Latest update manufacturer's descriptions 31.07.1996

Filterable list

Active ingredient:

ATX

Pharmacological group

Nosological classification (ICD-10)

Composition and release form

One dose liquid preparation contains at least 100 IU of antialphastaphylolysin; in ampoules of 3-5 ml, in a package of 10 pcs. Stabilizer - glycine at a final concentration of 22.5+.−7.5 mg/ml. Sodium chloride concentration in finished product 9+,−0.5 mg/ml.

Characteristic

An immunologically active protein fraction containing antibodies to staphylococcal exotoxin, isolated from serum or blood plasma of donors, purified and concentrated by fractionation with ethyl alcohol. It is a clear or slightly opalescent liquid, colorless or with a faint yellow color. During storage, a slight sediment may appear, which disappears with shaking.

Pharmacological action

Pharmacological action- immunostimulating.

Binds staphylococcal exotoxin.

Indications of the drug Human immunoglobulin antistaphylococcal

Staphylococcal infections.

Contraindications

Hypersensitivity.

Side effects

Hyperemia at the injection site, increased temperature, allergic reactions.

Directions for use and doses

IM, into the upper outer quadrant of the gluteal muscle. For generalized staphylococcal infection, the minimum single dose is at least 100 IU. The course of treatment is 3-5 injections given daily or every other day.

Precautions

After administration, patients must be monitored for 30 minutes (possibility of allergic reactions). Funds should be prepared antishock therapy. The drug is not suitable for use in ampoules with damaged integrity and labeling, if the physical properties(turbidity, intense coloring, presence of unbreakable flakes), expired, improperly stored.

Storage conditions for the drug Human immunoglobulin antistaphylococcal

At a temperature of 2-8 °C (do not freeze).

Keep out of the reach of children.

Shelf life of the drug Human immunoglobulin antistaphylococcal

2 years.

Do not use after the expiration date stated on the package.

Instructions for medical use

from 2010-05-15
Human antistaphylococcal immunoglobulin - instructions for use medical use- RU No.

Staphylococcus is a genus of bacteria that is widespread almost everywhere. They are found in water, in soil, and normally live on the skin of humans and animals. Doctors classify them as opportunistic microflora. That is, staphylococci can quietly exist next to you and not cause any trouble. However, under certain conditions, for example, with a cold or the appearance of chronic diseases, they can become a source of dangerous infectious diseases.

What is antistaphylococcal immunoglobulin?

It is staphylococci that often cause the development of bronchitis, tonsillitis and pneumonia, and in severe form. Antibiotics are not always able to cope with this infection, and then doctors resort to the help of such a remedy as antistaphylococcal immunoglobulin.

Immunoglobulins, or antibodies, are a special type of proteins that are produced by the human immune system in response to any aggressive agent, it can be a virus or bacteria. For everyone a separate type Bacteria have their own personal immunoglobulins. Thus, staphylococcal bacteria are dangerous specifically for this type of bacteria and will be powerless against diseases caused by other pathogens.

Getting from the drug into the blood, immunoglobulins attack and destroy bacteria. That is, they work the same way as ordinary cells immune system. But due to the fact that proteins in such a preparation are contained in high concentration, the effect of its use develops faster and is more pronounced.

Do not confuse antistaphylococcal immunoglobulin and bacteriophage. The first contains proteins of the immune system, and the second special viruses that can destroy bacteria. Despite the similarity of action, these are two different medicines and one cannot be replaced with the other.

Features of treatment

Staphylococcal immunoglobulin is used only intramuscularly, all other methods of use are prohibited. After administration, the maximum concentration in the blood is reached within 24 hours. The drug also takes a long time to leave the body, up to five weeks.

Injections can be prescribed daily or every other day, and the course lasts from three to five days. The treatment regimen will primarily depend on the severity of the disease.

The drug contains purified proteins, which means it rarely causes allergies. In addition, immunoglobulin has its own characteristics:

It is used only after a staphylococcal infection has been confirmed.
If you are suffering allergic diseases, for example, bronchial asthma, then on the day of the injection and throughout the next week, the doctor may additionally prescribe you antihistamines.
In case of exacerbation of allergies, immunoglobulin can be used only after consulting an allergist.
To those who suffer autoimmune diseases, the drug is prescribed only against the background of maintenance therapy.
Immunoglobulin affects the effectiveness of vaccines, so vaccinations are prescribed no earlier than two to three months after the last injection.

Immunoglobulin can be used only as prescribed by a doctor, alone or as an addition to the main treatment. Doctors often combine it with antibiotics.

Contraindications and contraindications

The drug can be prescribed for any infections caused by staphylococcus, for example, it is used for severe forms of bronchitis, pharyngitis and pneumonia. It has practically no contraindications, with the exception of an allergic reaction to the substances included in its composition or cases of anaphylactic shock to human blood products in the past.

Even during pregnancy and breastfeeding, immunoglobulin can be prescribed in cases where treatment with other methods has proven ineffective. At the same time, its active substance can penetrate into milk and enter the baby’s body. Therefore, doctors advise switching to artificial feeding for the duration of treatment. There are no contraindications for this drug based on age. But if it is prescribed to children under five years of age, the dose is selected individually.

As for side effects, these are usually dyspeptic symptoms and rarely an increase in temperature to 37.5, hyperemia at the site of administration. As a rule, they all go away on their own within 24 hours after administration. It is extremely rare that anaphylactic shock may develop, so the patient remains under observation in the first 30 minutes after the injection.

Antistaphylococcal immunoglobulin is quite effective medicine and allows you to cope with even severe infections. However, it is prescribed only by a doctor and used in a hospital.

Antistaphylococcal immunoglobulin is a drug that usually prescribed as an additional. However, it has proven effective in many clinical cases and is deservedly recommended for use by specialists.

Indications

Indications for the use of this drug may be as follows:

generalized infections caused by staphylococci;
staphylococcal infections of the skin and mucous membranes;
septic conditions.

These readings are the main, but it is possible to use staphylococcal immunoglobulin in other cases if the prescription is justified by the attending physician.

Contraindications

An absolute contraindication to injection of human antistaphylococcal immunoglobulin is hypersensitivity. If he previously experienced allergic reactions when administering donor blood components, he is prohibited from receiving anti-staphylococcal immunoglobulin.

There are cases when the benefits of administering the drug outweigh the harm. Here we're talking about about vital signs. For example, a patient has developed a severe septic condition and the use of this drug is indicated. Even if he previously had allergic reactions to blood products, an injection of immunoglobulin will save his life.

There are always exceptions: if this seriously ill patient previously had anaphylactic shock from receiving blood products, then even vital signs antistaphylococcal immunoglobulin is contraindicated.

People with a tendency to allergic reactions should take antihistamines while receiving anti-staphylococcal immunoglobulin therapy.

In this way, they protect themselves from dangerous consequences.

Compound

Antistaphylococcal immunoglobulin is a protein fraction of human blood plasma. It contains antibodies to staphylococcal toxins. Immunoglobulins are obtained by centrifuging donor blood. The composition also includes stabilizers glycine and sodium chloride.

Release forms

This medicine is available in the form of a solution in ampoules of 3 and 5 ml.

One ampoule contains 100 IU of the drug.

The solution is either colorless or slightly yellowish.

There may be sediment, which disappears with shaking.

Instructions for use

Immunoglobulin is injected intramuscularly into the upper outer quadrant of the gluteus maximus muscle, or into the middle part of the triceps femoris muscle. Before administration, it is necessary to hold the ampoules of the medicine for 2-3 hours at a temperature of about 20 degrees. If the solution contains persistent flakes, solid sediments, or the ampoule shows signs of damage, then using such a solution is strictly prohibited!

If the notes on the ampoule are erased, then it use is also prohibited.

After the administration of immunoglobulin, a record of the injection is made in a special journal with data on the expiration date, batch, number, and manufacturer of the drug. Within half an hour, the patient must be present in the area of attention of the doctors in order to immediately provide assistance if necessary. emergency assistance. To do this, there should always be an anti-shock kit in the treatment room.

Dosages

The dose of immunoglobulin is calculated from the ratio of 5 IU per 1 kg of body weight.

For staphylococcal skin infections and acne, the course of the drug is at least 5 injections.

Features of use in children

In children this drug usually used infrequently. The dose of the administered drug should not be less than 100 IU. One ampoule contains 100 IU.

Features of use in pregnant women

The use of immunoglobulin in pregnant and nursing mothers is not recommended, as it may cause undesirable consequences.

If possible, it is necessary to protect the fetus and infants from the use of drugs.

Antistaphylococcal immunoglobulin easily passes through the placental barrier and is detected in breast milk, so it should be administered only for health reasons, when the benefit outweighs the harm.

Features of use in the elderly

Older people usually tolerate this drug well, so dosage adjustments are not required.

Where to buy?

Antistaphylococcal immunoglobulin can be purchased at almost any pharmacy. But due to the price and rarity of use, it is better to look for it in large pharmacies.

The price of human antistaphylococcal immunoglobulin ranges from 10,000 rubles per package of 10 ampoules.

Storage and expiration dates

It is recommended to store immunoglobulin at a temperature of 2 to 8 degrees, but under no circumstances should the ampoules be frozen! Because when frozen, antibodies are destroyed and lose their activity. Transportation is also carried out at this temperature. The shelf life of the drug is 24 months.

Interaction with other drugs

Antistaphylococcal immunoglobulin does not affect the activity of other drugs.

Overdose and side effects

No cases of overdose have been identified. Side effects consist either in local irritation when the drug is administered, or in the development of allergic reactions, the proportion of which is extremely small.

Conclusion

Antistaphylococcal immunoglobulin is an excellent remedy in the treatment of staphylococcal skin infections, various pimples, as additional remedy V complex therapy septic conditions.

Source: 1pokrovi.ru

Instructions for use:

HUMAN IMMUNOGLOBULIN ANTISTAPHYLOCOCCAL,

solution for intramuscular injection 100 ME

Registration number: R N000942/01 dated 07/08/2008.

The drug is a concentrated solution of a purified fraction of immunoglobulins, isolated by fractionation with ethyl alcohol at temperatures below 0 °C from the blood plasma of healthy donors, containing antibodies to staphylococcal exotoxin and tested individually from each donor for the absence of hepatitis B virus surface antigen (HBsAg), antibodies to hepatitis C virus and human immunodeficiency virus HIV-1 and HIV-2.

Transparent or slightly opalescent liquid, colorless or slightly yellow in color. During storage, slight sediment may appear, which disappears after gentle shaking at a temperature of (20 ± 2) °C.

One dose (1 ampoule) contains at least 100 IU of antialphastaphylolysin. Stabilizer - glycine at a concentration of (2.25±0.75)%. The protein concentration in immunoglobulin is from 9.5 to 10.5%. The drug does not contain preservatives or antibiotics.

Immunological properties.

The active principle of the drug is immunoglobulins, which have the activity of antibodies that neutralize staphylococcal exotoxin (alphastaphylolysin).

Purpose.

Treatment of diseases of staphylococcal etiology in children and adults.

Directions for use and dosage.

Liquid antistaphylococcal immunoglobulin is injected intramuscularly into the upper outer quadrant of the gluteal muscle or into the outer surface of the thigh. Before injection, ampoules with the drug are kept for 2 hours at room temperature from 18 to 22 °C.

The opening of the ampoules and the administration procedure are carried out when strict adherence rules of asepsis and antiseptics. To avoid foam formation, the drug is drawn into a syringe with a wide bore needle. The drug cannot be stored in an opened ampoule.

The dose of the drug and the frequency of its administration depend on the indications for use:

- with generalized staphylococcal infections, the minimum single dose is 5 IU of antialphastaphylolysine per 1 kg of body weight (for children less than 5 years old, the single dose of the drug should be at least 100 IU);

- for localized diseases the minimum single dose is at least 100 IU.

The course of treatment consists of 3 - 5 injections given daily or every other day, depending on the severity of the disease and therapeutic effect.

Side effects.

As a rule, there are no reactions to the administration of immunoglobulin. IN in rare cases may develop local reactions in the form of hyperemia and an increase in temperature to 37.5 ° C during the first day after administration of the drug. Individuals with altered reactivity may develop allergic reactions various types, and in extremely rare cases - anaphylactic shock, in this regard, people who have been administered the drug should be under medical supervision for 30 minutes after its administration.

Vaccination sites must be provided with anti-shock therapy.

The administration of immunoglobulin is registered in established accounting forms indicating the manufacturer, batch number, date of manufacture, expiration date, date of administration, dose and nature of the reaction to the administration.

Contraindications.

The use of antistaphylococcal human immunoglobulin is contraindicated in persons with a history of severe allergic reactions to the administration of human blood products.

In cases of severe sepsis, the only contraindication for the use of the drug is a history of anaphylactic shock when administering human blood products.

For persons suffering from allergic diseases or with a history of clinically significant allergic reactions, antihistamines are recommended on the day of immunoglobulin administration and for the next 8 days.

Persons suffering from immunopathological systemic diseases(blood diseases, connective tissue, nephritis, etc.), the drug should be administered against the background of appropriate therapy.

The drug is not suitable for use if the integrity of the ampoules or their labeling is damaged, the physical properties are changed (turbidity, color change, the presence of unbreakable flakes), if the expiration date has expired and the storage conditions are not met.

Interactions with others medicines.

Not installed.

Release form.

1 dose (at least 100 IU) in a volume of 3 to 5 ml in ampoules. A) 10 ampoules in a cardboard pack with instructions for use. B) 5 or 10 ampoules in blister packs. 1 or 2 blister packs in a pack with instructions for use, an ampoule knife or an ampoule scarifier.

Vacation conditions.

Dispensed with a doctor's prescription.

Best before date. Storage and transportation conditions.

Best before date. 2 years. A drug that has expired cannot be used. Store and transport in accordance with SP 3.3.2.1248-03 at a temperature of 2 to 8 °C out of the reach of children. Freezing is not allowed.

Manufacturer. FSUE NPO Microgen, Russia.

Staphylococcal therapeutic vaccine

Vaccination is administered to form a stable immune system against dangerous microorganisms. It is injected under the skin into the area under the shoulder blade or shoulder. To achieve the desired effect, the vaccine is administered once. If necessary and according to the doctor's instructions, re-injection is allowed 14 days after the first injection.

The complex contains bacterial antigens that are resistant to thermal temperature changes. The staphylococcus vaccine contains many active ingredients that are extracted from microorganism cells using a special program. The vaccine contains:

carbohydrate phosphate-containing heteropolymers;
heteropolymer of N-acetylglucosamine and N-acetylmuramic acid;
hydroxybenzene (additional component).

The drug is a yellowish suspension with a specific odor, packaged in special ampoules. IN cardboard box You can purchase one or five ampoules at once for vaccination.

Ceftriaxone for staphylococcus

Ceftriaxone is available exclusively as an injection for intramuscular or intravenous administration. It is advisable that it be used exclusively in inpatient settings.

The product is effective against any pathogenic microbes, which can be gram-positive or negative. However, most often it is prescribed to destroy various coccal infections. The drug will not be effective enough against gram-positive cocci, Escherichia coli, hemophilus and some other gram-negative microorganisms. The drug is also recommended for use in the treatment of sexually transmitted diseases, even for secondary treatment.

The drug discussed in the article has excellent penetrating characteristics. Its active components pass the placenta barrier and even enter the breast milk. The active substances of the drug remain in the body for quite a long time (a day, a day and a half). Therefore, doctors allow only one injection per 24 hours.

When paying attention to effectiveness, the form of administration of the drug does not matter. When administered intravenously or intramuscularly, all active substances work against infection. However, when acute form during the course of the disease, and especially with a large dose, exclusively intravenous administration is prescribed.

In young children and the elderly, the active substances of the drug remain in the body for up to 7 days. It is excreted by the liver in equal proportions. The peculiarity of the components is that if the liver malfunctions, all active substances are excreted through the kidneys.

Gammaglobulin is a fairly popular drug for the prevention of many viral and coccal infections.

Due to the fact that the Union carried out planned and compulsory vaccination for women expecting a child, classic gammaglobulin contains protein compounds in the blood plasma in a large percentage. The average concentration of antibodies in gammaglobulin can reach 12AE.

Gammaglobulin, which is extracted from serum, during research saved animals that were specifically infected with a harmful infection from death. Except high content active substances drug in the blood, gammaglobulin entered the amniotic fluid. Therefore, pregnant women are not recommended to receive a double dose of the vaccine or revaccination.

Consequently, today, due to the frequent vaccination of pregnant women against Staphylococcus aureus, classical gammaglobulin mainly contains anti-staphylococcal protein compounds in blood plasma. The vaccine can be recommended as the main component of complex therapy for patients dangerous illnesses. It is especially worth introducing when reducing protective functions body.

Doctors use gammaglobulin to treat patients varying degrees staphylococcus. It is also used for toxic digestive disorders, pneumonia, inflammation of the colon and small intestine. According to laboratory research, the treatment method described in the article has positive impact on the development of the disease and contributes to the maximum effective recovery healthy microflora.

However, it is necessary to note that in some patients, when the desired clinical result is achieved and visible improvements occur, after using gammaglobulin (after 14-21 days), a relapse of the disease is observed, and often the disease is localized with new progress. This signals that the vaccine should be combined with drugs that increase the activity of the immune system.

Vaccination against staphylococcal infection

Is the most effective means against the disease in question. It contains active protein components that are extracted from human blood plasma. The fraction is pre-purified.

The main substance in the drug is staphylococcal immunoglobulin, which perfectly attacks a certain class of microorganisms. After administration of the active substance, its maximum concentration is reached within a day. If you pay attention to the withdrawal period active ingredients from the body, it is quite long and is approximately 4 – 5 weeks.

Vaccine administration regimen

For children up to school age, the dose of the drug should be 0.1 grams. If the body reacts positively to the introduction of active substances, the dosage is gradually doubled. If the baby was premature, vaccines are given only after he reaches the required age.

Pay attention! The dose of the drug and the schedule of vaccine administration must be agreed with the attending physician.

Children, after reaching the age of seven, are vaccinated according to the following method: day one - the vaccine is administered in a dosage of 0.2 ml. After a few days, the dose is increased by 0.1 ml. As a result, one milliliter of the drug must be injected into the patient’s body.

Pay attention! If the human body reacts negatively to medicinal product, further administration is prohibited until the negative symptoms. The course of administration continues with the same dosage at which vaccination was interrupted.

Negative reactions

At the injection site, the skin may become red due to active blood flow, and may also appear discomfort. In rare cases, the temperature rises slightly and the injection site becomes inflamed.
A vaccine against the disease in question, with reintroduction, may cause pain in some infectious foci.
If other negative reactions occur, you should immediately consult a doctor and undergo a comprehensive examination.

When is it prohibited to use the drug?

A vaccine against a harmful microorganism is prohibited:

with a severe disorder of bone formation of the second/third degree;
children under six months of age;
for eating and digestive disorders of the second/third degree;
for diseases of the endocrine system;
at the first allergic manifestations;
with attacks of suffocation of various origins;
with chronic pneumonia;
for diseases of the central nervous system;
for chronic illnesses;
for illnesses during exacerbation;
while expecting a baby or feeding him breast milk;
for liver and kidney diseases.

It is prohibited to administer the staphylococcus vaccine if the integrity of the container is damaged, if there is some sediment in the suspension or if the drug cannot be used due to the expiration date.

Special instructions

Before starting treatment and administering the vaccine, it is necessary to mandatory consult with your treating specialist. They may be pediatrician or therapist. If the disease occurs with relapse or active infectious spread on the skin, then it is rational to prescribe a second course of treatment, which may be identical to the previous one.

Manufacturer: PJSC "Biopharma" Ukraine

PBX code: J06B B08

Farm group:

Release form: Liquid dosage forms. Solution for injection.

General characteristics. Compound:

Active ingredients- specific antibodies active against staphylococcal alpha-exotoxin. One dose of the drug contains at least 100 IU of antialphastaphylolysin.

excipients - glycine (glycocol, aminoacetic acid), sodium chloride.

Main properties: the drug is an immunologically active protein fraction isolated from human serum or plasma tested for the absence of antibodies to HIV-1, HIV-2, hepatitis C virus and hepatitis B virus surface antigen, purified and concentrated by fractionation with alcohol-water precipitating solutions , which has undergone the stage of viral inactivation using the solvent-detergent method. Transparent or slightly opalescent, colorless or yellowish liquid. During storage, a slight sediment may appear, which disappears with shaking. The protein content in 1.0 ml of the drug is from 0.09 g to 0.11 g. The drug does not contain preservatives or antibiotics.

Pharmacological properties:

The drug contains high concentrations antibodies to staphylococcal alpha-exotoxin. It is a targeted immunoglobulin: it compensates for the lack of specific neutralizing antibodies in the body.

Indications for use:

The drug is used to treat diseases of staphylococcal etiology in children and adults.

Important! Get to know the treatment

Directions for use and dosage:

Immunoglobulin is administered intramuscularly.

In the case of generalized staphylococcal infection, the minimum single dose of the drug is 5 IU of antialphastaphylolysin per 1 kg of body weight (for children under 5 years of age, a single dose is at least 100 IU). For mild localized diseases, the minimum single dose of the drug is at least 100 IU. Injections are carried out daily or every other day, depending on the severity of the disease, the patient’s condition and the therapeutic effect. The course of treatment is 3 - 5 injections.

Features of application:

It is prohibited to administer the drug intravenously!

The sick, the suffering allergic diseases, or those with a history of severe allergic diseases, on the day of immunoglobulin administration and for the next 8 days, it is recommended to prescribe antihistamines. For persons with immunopathological systemic diseases (diseases of the blood, connective tissue, etc.), immunoglobulin should be administered against the background of appropriate therapy.

Side effects:

As a rule, there are no reactions to the administration of immunoglobulin. In rare cases, local reactions may occur in the form of hyperemia and an increase in temperature to 37.5 o C during the first two days after administration of the drug. The drug may cause allergic reactions in some people with altered reactivity. different types, and in extremely rare cases - . In this regard, persons who received the drug must be under medical supervision for 30 minutes.

Interaction with other drugs:

Combination with other specific drugs is possible.

Contraindications:

The administration of immunoglobulin is contraindicated in persons with a history of severe allergic reactions to the administration of human blood protein products. In severe cases, the only contraindication is a history of anaphylactic shock to human blood products.

Overdose:

Not studied.

Storage conditions:

In a dry place, protected from light, at a temperature of 2°C to 8°C. Keep out of the reach of children.

Vacation conditions:

By prescription

Package:

100 MO (1 dose) per ampoule. 3, 5 or 10 ampoules per pack.

Human antistaphylococcal immunoglobulin is a concentrated solution of a purified fraction of immunoglobulins containing antibodies to staphylococcal exotoxin. It was isolated by fractionation with ethyl alcohol from the blood plasma of healthy donors and tested individually from each donor for the absence of hepatitis B virus surface antigen (HBsAg), antibodies of the human immunodeficiency virus HIV-1 and HIV-2, as well as to the hepatitis C virus. Doctors at the Yusupov Hospital use a solution for intramuscular administration of 100 ME in the composition complex treatment severe forms staphylococcal infection.

The therapy clinic has all the conditions for treating patients:

comfortable rooms;
attentive attitude personnel;
application innovative methods examinations;
usage effective drugs with minimal side effects.

The Yusupov Hospital employs candidates and doctors of medical sciences, doctors highest category. All complex cases diseases are discussed at a meeting of the expert council with their participation. Patients have the opportunity to undergo the most complex examinations at partner clinics. Human antistaphylococcal immunoglobulin, registered in the Russian Federation, is used to treat patients.

Human antistaphylococcal immunoglobulin can be purchased in Moscow with a doctor’s prescription. The drug is transported at air temperatures from +4 to +8°C. In the therapy clinic, immune drugs are stored in the refrigerator. Before use, the ampoules are kept at room temperature for 2 hours.

Characteristics of human antistaphylococcal immunoglobulin

You can buy anti-staphylococcal human immunoglobulin in pharmacies. It is a clear or slightly opalescent liquid, colorless or slightly yellow in color. During storage, a slight sediment may appear, which should disappear after gentle shaking at a temperature of 20 ° C.

One glass ampoule contains 1 dose of staphylococcal immunoglobulin (at least 100 IU antialphastaphylolysin). Glycine is used as a stabilizer at a concentration of 2.25%. Human antistaphylococcal immunoglobulin (can be purchased in online pharmacies) contains from 9.5 to 10.5% protein. The drug is made without the use of preservatives and antibiotics.

The active principle of the drug is immunoglobulins. They neutralize staphylococcal exotoxin. The maximum concentration of antibodies in the blood is reached after 24 hours, the half-life of antibodies from the body is 4-5 weeks. Staphylococcal immunoglobulin can be bought in Moscow. It is used for the treatment of staphylococcal diseases in children and adults.

Method of use of antistaphylococcal immunoglobulin

Antistaphylococcal immunoglobulin is injected intramuscularly into the upper outer quadrant of the buttock or into the outer surface of the thigh. Nurses at the Yusupov Hospital strictly follow the rules of asepsis and antisepsis when opening the ampoule and performing the injection. To avoid foam formation, the drug is drawn into a syringe with a wide bore needle. A different needle is used to inject immunoglobulin. The drug should not be stored in an opened ampoule.

Therapists individually determine the dose of the drug and the frequency of its administration depending on the indications for use. For patients with generalized staphylococcal infection The minimum single dose of the drug is 5 IU of antialphastaphylolysine per 1 kg of body weight. Children under 5 years of age are used single dose antistaphylococcal immunoglobulin not less than 100 IU. Patients with localized diseases are given a one-time dose of at least 100 IU of human antistaphylococcal immunoglobulin. The course of therapy consists of 3 - 5 injections. Depending on the severity of the disease and the therapeutic effect, they are done daily or every other day.

Contraindications to the use of antistaphylococcal immunoglobulin

Human antistaphylococcal immunoglobulin is not used to treat patients with a history of severe allergic reactions to the administration of blood products. In patients suffering severe form sepsis, the only contraindication for the use of the drug is anaphylactic shock, which developed in the past after the administration of blood products.

For persons suffering from allergic diseases or clinically significant allergic reactions, doctors at the Yusupov Hospital prescribe antihistamines on the day of immunoglobulin administration and for the next 8 days. For patients with immunopathological systemic diseases (diseases of the blood, connective tissue, nephritis), the drug is administered against the background of appropriate therapy. During pregnancy and breastfeeding, human antistaphylococcal immunoglobulin is used only for health reasons.

Antistaphylococcal immunoglobulin is not suitable for use if the integrity of the ampoules or their labeling is damaged and the physical properties of the solution change (turbidity, color change, presence of unbreakable flakes). Do not administer a drug that has expired or was stored in violation of the conditions prescribed by the instructions.

When antistaphylococcal immunoglobulin is administered, most patients have no side effects. In rare cases, during the first day after administration of the drug, local reactions develop in the form of redness and an increase in body temperature to 37.5 ° C. Some patients with altered reactivity sometimes develop allergic reactions, and in extremely rare cases, anaphylactic shock. Patients after administration of immunoglobulin are under medical supervision for 30 minutes after administration. The manipulation room of the Yusupov Hospital is equipped with anti-shock therapy. When anaphylactic reactions develop, patients are administered antihistamines, adrenergic agonists and glucocorticosteroid hormones.

Administration of antistaphylococcal immunoglobulin nurses registered in established accounting forms. They indicate the manufacturer, batch number, date of manufacture, expiration date, date of administration of the drug, dose and nature of the reaction to administration.

Human antistaphylococcal immunoglobulin is produced in glass ampoules in one dose (at least 100 IU) in a volume of 3 to 5 ml. The price of 10 ampoules in a cardboard pack with instructions for use can vary from 11,223 to 12,699 rubles. The kit includes an ampoule knife or scarifier. Ampoules may have a colored break ring, a notch or an identifying colored dot on the clamp.

Get a consultation with a therapist by first making an appointment by calling the Yusupov Hospital. The doctor will determine the indications and contraindications for the use of human antistaphylococcal immunoglobulin and draw up an individual treatment regimen. Compliance with the rules for administering the drug by the staff of the Yusupov Hospital prevents the development of complications.