ACC (Acetylcysteine) is a drug with an expectorant and mucolytic effect, which is prescribed to liquefy viscous bronchial secretions in diseases of the organs. respiratory system, occurring with the formation of thick, difficult to clear sputum.

In this article we will look at why doctors prescribe ACC, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS People who have already used ACC can be read in the comments.

Composition and release form

The active substance of ACC is acetylcysteine. The following types of the drug are produced:

1. Effervescent tablets ACC 100, ACC 200 and ACC Long, containing 100 mg, 200 mg and 600 mg of acetylcysteine, respectively;
2. Granules for the preparation of a solution for oral administration ACC, one package contains 100 or 200 mg of acetylcysteine ​​- granules with the smell of orange, 200 or 600 mg of the active substance - granules with the smell of lemon and honey;
3. Orange granules for the preparation of syrup for oral administration of ACC. 5 ml of finished syrup contains 100 mg of acetylcysteine.
4. Solution for intramuscular and intravenous administration ACC Inject, 1 ml of which contains 300 mg of acetylcysteine.

Clinical and pharmacological group: mucolytic drug.

What does Azts help with?

The main indications for use are:

• acute or chronic sinusitis;
• respiratory disease;
• acute and chronic, as well as obstructive bronchitis;
• pneumonia;
• tracheitis;
• lung abscess;
• bronchial asthma;
• Otitis media

Pharmacological action

The active substance is acetylcysteine, a derivative of cysteine ​​(amino acid). It has a mucolytic, expectorant effect due to the rupture of bisulfide bonds of sputum mucopolysaccharides. This depolymerizes mucoproteins and increases the viscosity of bronchial secretions.

As a result, mucociliary clearance increases and sputum discharge improves. Acetylcysteine ​​has an antioxidant and pneumoprotective effect, which is associated with the binding properties of sulfhydryl groups. Is an antidote for acute poisoning aldehydes, paracetamol and phenols (detoxifying effect is possible due to increased glutathione production).

Instructions for use

The tablet should be dissolved in water (100 ml) and taken immediately after preparation. In exceptional cases, it is permissible to store the solution for a maximum of 2 hours. Take after meals, with additional water.

• Children aged 2 to 5 years are recommended to take the drug 1 tablet. (ACC 100) or 1/2 tab. (ACC 200) 2-3 times/day, which corresponds to 200-300 mg of acetylcysteine ​​per day.
• Children aged 6 to 14 years are recommended to take 1 tablet. (ACC 100) 3 times/day, or 2 tablets. (ACC 100) or 1 tablet. (ACC 200) 2 times/day, which corresponds to 300-400 mg of acetylcysteine ​​per day.
• For adults and adolescents over 14 years of age, it is recommended to prescribe the drug 200 mg 2-3 times/day (ACC 100 or ACC 200), which corresponds to 400-600 mg of acetylcysteine ​​per day, or 600 mg (ACC Long) 1 time/day.

For short-term colds Duration of treatment is 5-7 days. At chronic bronchitis and cystic fibrosis, the drug should be used for a longer period of time to prevent infections.

Contraindications

The drug should not be used in the following cases:

• hypersensitivity to acetylcysteine ​​or to any other ingredients of the medicine;
• exacerbation of peptic ulcer;
• pulmonary bleeding;
• pregnancy and breastfeeding;
• glucose-galactose malabsorption;
• hemoptysis;
• lactase deficiency, lactose intolerance;
• child's age up to 2 years.

Side effects

ACCs are generally well tolerated; when taken orally in the form of a solution, a number of side effects may develop, which include:

• From the outside cardiovascular system– tachycardia (increased heart rate), arterial hypotension(decrease in systemic blood pressure).
• From the digestive system - nausea, sometimes vomiting, heartburn, stool disorder in the form of diarrhea (diarrhea).
• From the central side nervous system – headache, tinnitus,
• Allergic reactions are rare and severity may vary. They manifest themselves in the form of a rash on the skin, itching, and urticaria (a rash and swelling of the skin that looks like a nettle burn). In extreme in rare cases there may be a reaction from the bronchi in the form of their spasm, reminiscent of an attack of bronchial asthma.

At very severe course an allergic reaction develops anaphylactic shock with the development of multiple organ failure against the background of a progressive decrease in systemic blood pressure.

In case of an erroneous or intentional overdose, phenomena such as diarrhea, vomiting, stomach pain, heartburn and nausea are observed.

Pregnancy and lactation

Because of insufficient quantity According to this data, the use of the drug during pregnancy is contraindicated. If it is necessary to use the drug during lactation, the issue of stopping breastfeeding should be decided.

Analogs

Medicines analogous to ACC - ACC Long, Fluimucil, Acetylcysteine, Acetal, Acestad, Acestin, etc. Only a specialist should choose the optimal drug.

Mucolytic drug.

Drug: ACC ®
Active substance: acetylcysteine
ATX code: R05CB01
KFG: Mucolytic drug
Reg. number: P No. 015474/01
Registration date: 01/13/05
Owner reg. cert.: HEXAL AG (Germany)

DOSAGE FORM, COMPOSITION AND PACKAGING

Granules for the preparation of solution for oral administration (orange) white, without agglomerates and mechanical impurities, with the smell of orange.

Excipients:ascorbic acid, saccharin, sucrose, orange flavor.

Granules for the preparation of solution for oral administration white, homogeneous, no more than 1.5 mm in size, without agglomerates and mechanical impurities, with the smell of lemon and honey.

Excipients: ascorbic acid, saccharin, sucrose, honey and lemon flavors.

3 g - sachets (6) - cardboard packs.
3 g - sachets (10) - cardboard packs.
3 g - sachets (20) - cardboard packs.

ACC ® 100

Effervescent tablets white, round, flat, with the smell of blackberries.

Excipients:

ACC ® 200

Effervescent tablets white, round, flat, scored, with the smell of blackberries.

Excipients: ascorbic acid, citric acid anhydride, lactose anhydride, mannitol, sodium citrate, sodium bicarbonate, saccharin, blackberry flavor.

4 pcs. - strips (15) - cardboard boxes.
20 pcs. - aluminum tubes (1) - cardboard boxes.
20 pcs. - plastic tubes (1) - cardboard boxes.
25 pcs. - aluminum tubes (2) - cardboard boxes.
25 pcs. - plastic tubes (2) - cardboard boxes.
25 pcs. - aluminum tubes (4) - cardboard boxes.
25 pcs. - plastic tubes (4) - cardboard boxes.

ACC ® LONG

Effervescent tablets white, round, with a smooth surface, scored, with the smell of blackberries.

Excipients: anhydrous citric acid, sodium bicarbonate, anhydrous sodium carbonate, mannitol, anhydrous lactose, ascorbic acid, sodium cyclamate, sodium saccharinate dihydrate, sodium citrate dihydrate, blackberry flavoring "B".

6 pcs. - polypropylene tubes (1) - cardboard packs.
10 pcs. - polypropylene tubes (1) - cardboard packs.
20 pcs. - polypropylene tubes (1) - cardboard packs.

The description of the drug is based on the officially approved instructions for use.

PHARMACOLOGICAL ACTION

Mucolytic drug. The presence of sulfhydryl groups in the structure of the acetylcysteine ​​molecule promotes the rupture of disulfide bonds of acidic mucopolysaccharides of sputum, which leads to a decrease in the viscosity of mucus. The drug remains active in the presence of purulent sputum.

At prophylactic use acetylcysteine ​​there is a decrease in the frequency and severity of exacerbations in patients with chronic bronchitis and cystic fibrosis.

PHARMACOKINETICS

Pharmacokinetic data ACC drug not provided.

INDICATIONS

Respiratory diseases accompanied by increased formation of viscous mucus that is difficult to separate (acute and chronic bronchitis, obstructive bronchitis, pneumonia, bronchiectasis, bronchial asthma, bronchiolitis, cystic fibrosis, laryngitis);

Acute and chronic sinusitis;

Otitis media

DOSING REGIME

Adults and teenagers over 14 years old it is recommended to prescribe the drug 200 mg 2-3 times a day (ACC 100 or ACC 200), or 200 mg 3 times a day (ACC in the form of granules for the preparation of a solution for oral administration 200 mg) or 600 mg 1 time / day (ACC LONG or ACC in the form of granules for the preparation of a solution for oral administration 600 mg).

Children aged 2 to 5 years The drug is recommended to be taken 100 mg 2-3 times a day (ACC 100 or ACC 200).

At cystic fibrosischildren over 6 years old the drug is recommended to be taken 200 mg 3 times a day (ACC 100, ACC 200 or ACC in the form of granules for the preparation of an oral solution of 200 mg). Children aged 2 to 6 years- 100 mg 4 times/day (ACC 100 or ACC 200). Patients with weighing more than 30 kg for cystic fibrosis, if necessary, you can increase the dose to 800 mg/day.

At sudden short-term colds Duration of treatment is 5-7 days. At chronic bronchitis and cystic fibrosis the drug should be used for a longer period of time to prevent infections.

The drug should be taken after meals. Additional reception liquid enhances the mucolytic effect of the drug.

Effervescent tablets (ACC 100 and ACC 200) should be dissolved in 1/2 glass of water, effervescent tablets (ACC LONG) should be dissolved in 1 glass of water. Take immediately after dissolution, in exceptional cases you can leave it ready solution for 2 hours

Granules for preparing a hot drink (1 sachet) are dissolved with stirring in 1 glass hot water and drink it hot if possible. If necessary, you can leave the prepared solution for 3 hours.

Granules for oral solution (orange scent) should be dissolved in water, juice or iced tea and taken after meals.

SIDE EFFECTS

From the side of the central nervous system: rarely - headaches, tinnitus.

From the outside digestive system: rarely - stomatitis; in some cases - diarrhea, vomiting, heartburn and nausea.

From the cardiovascular system: in some cases - a drop in blood pressure, tachycardia.

From the respiratory system: in isolated cases - the development of pulmonary hemorrhage as a manifestation of the reaction hypersensitivity.

Allergic reactions: in isolated cases - bronchospasm (mainly in patients with a hyperreactive bronchial system with bronchial asthma), skin rash, itching and urticaria.

CONTRAINDICATIONS

Gastric ulcer and duodenum in the acute phase;

Hemoptysis;

Pulmonary hemorrhage;

Pregnancy;

Lactation period (breastfeeding);

Children under 6 years of age (the drug is in the form of granules for the preparation of a solution for oral administration 200 mg);

Children under 14 years of age ( dosage forms drug containing acetylcysteine ​​600 mg);

Hypersensitivity to acetylcysteine ​​and other components of the drug.

WITH caution the drug should be used in patients with varicose veins veins of the esophagus, with increased risk development of pulmonary hemorrhage and hemoptysis, with bronchial asthma, diseases of the adrenal glands, liver and/or kidney failure.

ACC LONG should not be prescribed to children under 14 years of age. In this category of patients, it is recommended to use dosage forms of the drug for oral administration with more low content acetylcysteine.

PREGNANCY AND LACTATION

Due to insufficient data, the use of the drug during pregnancy and lactation is possible only in cases where the expected benefit to the mother outweighs the potential risk to the fetus or child.

SPECIAL INSTRUCTIONS

For bronchial asthma and obstructive bronchitis acetylcysteine ​​should be prescribed with caution under systematic monitoring of bronchial patency.

During development side effects the drug should be discontinued.

When dissolving the drug, it is necessary to use glass containers and avoid contact with metals, rubber, oxygen, and easily oxidized substances.

1 tablet effervescent ACC 100 and ACC 200 corresponds to 0.006 XE.

1 effervescent tablet ACC LONG corresponds to 0.01 XE.

ACC (in the form of granules for the preparation of an oral solution of 200 mg) corresponds to 0.21 XE, ACC (in the form of granules for the preparation of an oral solution of 600 mg) - 0.17 XE.

ACC (in granules for the preparation of a solution for oral administration 100 mg and 200 mg with the scent of orange) 100 mg corresponds to 0.24 XE, 200 mg - 0.23 XE.

Use in pediatrics

OVERDOSE

Symptoms: Possible diarrhea, vomiting, stomach pain, heartburn, nausea.

Treatment: carrying out symptomatic therapy.

DRUG INTERACTIONS

With the simultaneous use of acetylcysteine ​​and antitussives, dangerous mucus stagnation may occur due to suppression of the cough reflex (use the combination with caution).

When taking acetylcysteine ​​and nitroglycerin simultaneously, the vasodilatory effect of nitroglycerin may be enhanced.

There is a synergism between acetylcysteine ​​and bronchodilators.

Pharmaceutical interactions

Acetylcysteine ​​is pharmaceutically incompatible with antibiotics (penicillins, cephalosporins, erythromycin, tetracycline and amphotericin B) and proteolytic enzymes.

Acetylcysteine ​​reduces the absorption of cephalosporins, penicillins and tetracycline, so they should be taken orally no earlier than 2 hours after taking acetylcysteine.

When acetylcysteine ​​comes into contact with metals and rubber, sulfides with a characteristic odor are formed.

CONDITIONS OF VACATION FROM PHARMACIES

The drug is approved for use as an over-the-counter product.

CONDITIONS AND DURATION OF STORAGE

The drug should be stored in a dry place, out of reach of children, at a temperature not exceeding 25°C. Shelf life - 3 years, shelf life of granules for preparing an oral solution (orange scent) - 4 years.

ACC LONG should be stored in a dry place, protected from light, out of reach of children, at a temperature not exceeding 30°C. Shelf life - 3 years.

After taking the tablet, the tube should be tightly closed.

In accordance with the instructions for medical use, ACC® tablets? should be dissolved in 1 glass of water and taken after meals.
Additional enhances fluid intake mucolytic effect of taking the drug.

How long can the prepared solution be stored?

The prepared solution should be taken immediately after dissolving the tablets or granules to prepare the solution. In exceptional cases, you can leave the ready-to-use solution for 2 hours.

What is the duration of taking ACC®?

For short-term colds Duration of treatment is from 4-5 to 5-7 days.
For chronic bronchitis of various etiologies the drug should be taken more long time under the supervision of a specialist. This will achieve a preventive effect.

For cystic fibrosis, acetylcysteine ​​is part of the basic therapy and is taken long-term according to an individual regimen.

Are there any peculiarities of taking ACC® together with other drugs?

Acetylcysteine ​​is active substance, so it is important to know how it interacts with other drugs:

• with the simultaneous use of acetylcysteine ​​and antitussives, sputum stagnation may occur due to suppression of the cough reflex, therefore such combinations are not recommended;
• simultaneous use with vasodilating agents and nitroglycerin can lead to increased vasodilator effect;
• It is recommended to take antibiotics no earlier than 2 hours after ingesting acetylcysteine, so as not to reduce their absorption.

With more detailed information Information about the interaction of the drug with other medications can be found in the instructions for use.

What are the signs that indicate that ACC® is working?

In practice, the criteria for the effectiveness of mucolytic therapy are usually: the following indicators:

• cough productivity (subjective assessment: sputum has become better coughed up);
• the time interval during which a non-productive (dry) cough 1 turned into a productive one;
• duration of detection of wheezing in the lungs (determined by a specialist);
• the duration of the period of illness during which obstruction persists in one of the sections of the respiratory tract (determined by a specialist).

At what age can you start taking ACC®?

ACC® can be used in children starting from 2 years of age in the form syrup, effervescent tablets(ACC® 100, ACC® 200) or granules for oral solution (orange) 100 mg and 200 mg.

Can ACC® be recommended for children with a dry/non-productive cough (when phlegm is not coughed up)?

If a cough 1 that occurs during the peak season of ARVI is accompanied by an increase in temperature and symptoms of intoxication, then YES - ACC® can be recommended at the onset of the disease. Since the appearance of a cough in this case is associated with inflammation respiratory tract, accumulation of viscous sputum in the respiratory tract. ACC®, by thinning sputum, accelerates the transition of a dry cough to a productive one and reduces the duration of the disease. 2

What is the difference between acetylcysteine ​​and ambroxol?

Both acetylcysteine ​​and ambroxol are mucolytic agents. If we compare ACC® with other mucolytics, including ambroxol, then the secretolytic ACC action® develops faster 3 . Ambroxol, having a mainly mucoregulating effect, slower reduces the viscosity of sputum. Therapeutic effect also enhance the antioxidant properties of acetylcysteine ​​4,5.

What is drainage gymnastics?

There are special exercises, aimed at improving the discharge of sputum, are the so-called drainage exercises. To improve the drainage function of the bronchi, they are used special drainage provisions and exercises with forced extended exhalation.

Positional (postural) drainage is the use of a certain body position for better discharge of sputum. Positional drainage is performed 2 times a day - morning and evening, but it can be done more often 1-2 hours after taking mucolytics. For 20-30 minutes, the patient alternately takes positions that promote maximum emptying of sputum from both lungs under the influence of gravity, so that it flows down the bronchi to the trachea and is easier to clear when coughing.

In each pose, the patient first performs 3-5 deep slow breathing movements , inhaling air through the nose and exhaling through pursed lips. Then, after taking a slow, deep breath, he coughs shallowly 3-4 times. Good results can be achieved by combining drainage provisions with various methods vibrations chest over the drained lung.

1. Cough as a symptom of respiratory diseases, accompanied by the formation of viscous, difficult to separate sputum.

2. Doctor, No. 8, 2010, p. 60-63

3. According to a comparative study involving 259 children with acute and chronic bronchopulmonary pathology under the age of 15 years (92 received acetylcysteine, 117 - abmroxol, 30 - bromhexine and 20 - mucaltin) it was found that on the 2nd day of using acetylcysteine The cough becomes productive, decreased on the 3rd day, and disappeared on the 4th-5th. When taking Ambrocosl, the intensity of the cough decreased significantly on the 4th day of therapy, and recovery occurred on the 5th-6th day. The effect of bromhexine occurred on average 1-2 days later than abmroxol and 2-3 days later than acetyl cysteine. When mucaltin was prescribed, the cough was severe for 6-8 days and recovery occurred by 8-10 days from the onset of the disease.
Adapted from:
Zaitseva O.V. Rational choice mucaltic therapy in the treatment of respiratory diseases in children. RMJ, 2009, T.17, No. 19, pp.1217-1222.

4. American Journal of Respiratory and Critical Care Medicine, 1997; (156):1897–1901

5. Instructions for the medical use of acetylcysteine ​​and ambroxol preparations, State Register medicines http://grls.rosminzdrav.ru/default.aspx, accessed 07/02/2018.

My health worsened and the first symptoms of the disease appeared. What are they telling us? Cough is defensive reaction our body, in this way it tries to cleanse itself of mucus and large quantity microbes The sooner this happens, the sooner your health will improve and the long-awaited recovery will come. It often happens that the mucus has a fairly thick structure, so when coughing it does not come out and a person cannot get rid of it so easily. It's easy to solve this problem in short time The drug ACC will help. How does it act on the body? Who should take it and when, and in what cases is it better not to use this drug? Now let's look at it in more detail.

ACC drug, basic concepts

Today this medicine is one of the most effective existing funds for cough. Acetylcysteine ​​is the main active ingredient, from which the name ACC comes. The substance was formed with the help chemical compounds and cysteine. The man who has already for a long time I have an annoying cough after using it this tool will feel much better. What causes a persistent cough? It's simple. Usually, in such people, thick mucus stagnates in the respiratory tract, which regularly irritates the mucous membranes, the phlegm interferes with normal air circulation, which subsequently results in a coughing attack. In this state pathogenic organisms prone to further reproduction, which results in long-term illness. It is no secret that at night the patient’s well-being worsens, causing both the patient and his family to suffer. In this case, treatment with acetylcysteine ​​is ideal; it is classified as a mucolytic agent; it promotes expectoration of sputum. Composition of the ACC helps to liquefy mucous membranes, thereby facilitating the removal of mucus from the respiratory tract.

The effect of the drug on the body

The active ingredients of the drug affect thick mucus at the molecular level. At this time, the compounds of sulfur atoms are destroyed, which allows the sputum to become more viscous. The drug ACC promotes the rapid removal of mucus from the respiratory tract and the body as a whole.

Elements of the drug can destroy the integrity of mucolysaccharides (viscous clots). The mucus will be easily coughed up until it is completely clear. bronchial tree. The person will notice that the cough has become wet, followed by expectoration of phlegm. Recovery will come in a short time. The substance acetylcysteine ​​can have a beneficial effect on inflammatory process, which occurs in the bronchi.

Purpose of the ACC

This drug should be taken by patients who have accumulation of sputum in the lungs, bronchi and other parts of the respiratory system.

Diseases that ACC can cure:

• Bronchial diseases;
• Chronic, acute, obstructive bronchitis;
• COPD (lung disease)
• Pneumonia
• Sinusitis (chronic stage)
• Larengitis, farengitis, tracheitis;
• Otitis (exudative);
• Cystic fibrosis.

The drug ACC is found in pharmacies in the form:

• Granular powder sachets;
• Effervescent tablets;
• Solution for intramuscular injections and drip infusions.

Each package indicates the number of milligrams: 600, 200 and 100. Therefore, ACC 100 indicates that there is 100 mg of acetylcystene in the bag. If the dose of ACC is 600 mg, then on such packaging there is a note “LONG”, given quantity medications must be taken once a day. Before use, the tablet or powder suspension should be dissolved in 100 ml of water. If the drug is prescribed to children, then it is allowed to dissolve it in juice and even milk. It is advisable that the water be warm or room temperature. It is best to take the medicine after meals. During treatment with the drug, try to consume as much as possible more water, especially recommended to drink mineral water"Borjomi", because it enhances the effect medicinal product.

ACC dosage

More information about admission to children under 14 years of age:

1. From 6-14 years old you need to take the drug 3 times a day, 100 mg.
2. From 2-5 years - 2 times a day with a dosage of 100 mg.
3. Children who are less than 2 years old are prescribed a dose on the recommendation of a doctor, no more than 50 mg several times a day.

The standard treatment period is 5-7 days. It all depends on the type of disease and its severity.

Side effects

Side effects exist, but are quite rare.

These include:

• Heartburn, nausea followed by vomiting, diarrhea;
• Decreased blood pressure, which is accompanied by dizziness and tinnitus;
• Increased heart rate;
• Various types of rash.

This drug is contraindicated in the following persons suffering from:

• pulmonary hemorrhage;
• hypersensitivity to drug components;
• kidney or liver problems;
• bronchial asthma.

Pregnant and breastfeeding women should avoid taking this medicine because there is very little data on how the medicine affects the fetus and the pregnant woman in general.

Doctors do not recommend taking ACC simultaneously with other cough medications. This can cause mucus to accumulate in the airways.

When combining ACC with nitroglycerin, remember that this drug will increase vasodilation.

It is incompatible to take ACC at the same time with antibiotics of some groups, so when purchasing an antibiotic, consult your doctor which group it belongs to and whether it can be combined with taking ACC medication. If not, then several hours should pass after taking ACC, and then you can take an antibiotic.

Pay special attention to studying the packaging of the drug, if it says on it that you need to prepare a hot drink from this powder, therefore, dissolve the medicine in hot water. The drug should be dissolved in a glass container, stirring the mixture using a porcelain spoon or wooden stick. No contact with metal! Stir until the drug is completely dissolved.

This is it effective property has the drug ACC. Follow all the doctor’s recommendations, pay attention to the packaging of the medicine, carefully study the instructions for use and only then begin treatment. You should not have any contraindications - this is important, because taking it can only aggravate this disease.

In this article you can read the instructions for use of the drug ACC. Feedback from site visitors - consumers - is presented of this medicine, as well as the opinions of specialist doctors on the use of ACC in their practice. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications were observed and side effects, perhaps not stated by the manufacturer in the annotation. Analogues of ACC, if available structural analogues. Use for the treatment of bronchitis and dry cough in adults, children, as well as during pregnancy and lactation. Various shapes release of a drug to thin sputum.

ACC- mucolytic drug. The presence of sulfhydryl groups in the structure of the acetylcysteine ​​molecule promotes the rupture of disulfide bonds of acidic mucopolysaccharides of sputum, which leads to a decrease in the viscosity of mucus. The drug remains active in the presence of purulent sputum.

With the prophylactic use of acetylcysteine, there is a decrease in the frequency and severity of exacerbations in patients with chronic bronchitis and cystic fibrosis.

Compound

Acetylcysteine ​​+ excipients.

Indications

• respiratory diseases accompanied by increased formation of viscous mucus that is difficult to separate (acute and chronic bronchitis, obstructive bronchitis, pneumonia, bronchiectasis, bronchial asthma, bronchiolitis, cystic fibrosis, laryngitis);
• acute and chronic sinusitis;
• Otitis media

Release forms

Powder or granules for making syrup 100 mg.

Syrup 100 ml.

Effervescent tablets 100 mg, 200 mg, 600 mg long.

Solution for injection ACC injection - 100 mg and 300 mg in 1 ml.

Instructions for use and dosage

Powder or effervescent tablets

Adults and adolescents over 14 years of age are recommended to prescribe the drug 200 mg 2-3 times a day (ACC in the form of granules for the preparation of an oral solution / orange / 100 mg and 200 mg), or 200 mg 3 (ACC in the form of granules for preparing a solution for oral administration 200 mg) or 600 mg 1 time per day (ACC in the form of granules for preparing an oral solution 600 mg).

Children aged 6 to 14 years are recommended to take 100 mg 3 times a day or 200 mg 2 times a day (ACC in the form of granules for oral solution / orange / 100 mg and 200 mg), or 200 mg 2 times a day (ACC in the form of granules for the preparation of a solution for oral administration 200 mg).

There is not enough data on the dosage of the drug in newborns.

For cystic fibrosis, children over 6 years of age are recommended to take the drug 200 mg 3 times a day (ACC in the form of granules for preparing an oral solution /orange/ 100 mg and 200 mg or ACC in the form of granules for preparing an oral solution 200 mg ).

Children aged 2 to 5 years - 100 mg 4 times a day (ACC in the form of granules for the preparation of an oral solution / orange / 100 mg and 200 mg).

For patients weighing more than 30 kg with cystic fibrosis, if necessary, the dose can be increased to 800 mg per day.

For sudden short-term colds, the duration of use is 5-7 days. For chronic bronchitis and cystic fibrosis, the drug should be used for a longer period of time to prevent infections.

The drug should be taken after meals. Additional fluid intake enhances the mucolytic effect of the drug.

Rules for preparing the drug

ACC in the form of granules for the preparation of a solution for oral administration /orange/ 100 mg and 200 mg: 1/2 or 1 sachet (depending on the dose) dissolved in water, juice or iced tea and taken after meals.

ACC in the form of granules for the preparation of a solution for oral administration 200 mg and ACC in the form of granules for the preparation of a solution for oral administration 600 mg: 1 sachet is dissolved with stirring in 1 glass of hot water and drunk, if possible, hot. If necessary, you can leave the prepared solution for 3 hours.

Syrup

Adults and adolescents over 14 years of age are prescribed 10 ml of syrup 2-3 times a day (400-600 mg of acetylcysteine).

Children aged 6 to 14 years - 5 ml of syrup 3 times a day or 10 ml of syrup 2 times a day (300-400 mg of acetylcysteine).

Children aged 2 to 5 years are prescribed 5 ml of syrup 2-3 times a day (200-300 mg of acetylcysteine).

For cystic fibrosis, children over 6 years of age are recommended to take the drug 10 ml of syrup 3 times a day (600 mg of acetylcysteine); children aged 2 to 6 years - 5 ml of syrup 4 times a day (400 mg of acetylcysteine).

For short-term colds, the duration of use is 4-5 days. For chronic bronchitis and cystic fibrosis, the drug should be used for a longer period of time to prevent infections. At long-term illnesses The duration of therapy is determined by the attending physician.

The drug is taken orally after meals. Additional fluid intake enhances the mucolytic effect of the drug.

ACC syrup is taken using a measuring syringe or measuring cup contained in the package. 10 ml ACC syrup corresponds to 1/2 measuring cup or 2 filled syringes.

Using a measuring syringe

1. Open the bottle cap by pressing on it and turning it counterclockwise.

2. Remove the cap with the hole from the syringe, insert it into the neck of the bottle and press in until it stops. The stopper is designed to connect the syringe to the bottle and remains in the neck of the bottle.

3. It is necessary to insert the syringe tightly into the stopper. Carefully turn the bottle upside down, pull the syringe plunger down and draw required quantity syrup (ml). If air bubbles are visible in the syrup, press the plunger all the way and then refill the syringe. Then return the bottle to starting position and remove the syringe.

4. The syrup from the syringe should be poured onto a spoon or directly into the child’s mouth (into the cheek area, slowly, so that the child can swallow the syrup). While taking the syrup, the child should be in an upright position.

5. After use, rinse the syringe with clean water.

Ampoules for injections

Adults are prescribed intravenously or intramuscularly at 300 mg (1 ampoule) 1-2 times a day.

Children aged 6 to 14 years are prescribed IV or IM 150 mg (1/2 ampoule) 1-2 times a day.

For children under 6 years of age, oral therapy is preferred, however, if indicated and necessary parenteral administration daily dose is 10 mg/kg body weight.

For children under 1 year of age, intravenous administration of the drug is possible only by vital signs in a hospital setting.

The duration of therapy is determined individually.

For chronic bronchitis and cystic fibrosis application of ACC INJECT for a long time can be combined with oral administration of the drug to prevent infections.

The mucolytic effect of acetylcysteine ​​increases with increased fluid intake.

Rules for injections

With intramuscular administration, when performing a shallow injection and in the presence of increased sensitivity, a slight and quickly passing burning sensation may occur, therefore it is recommended to administer the drug to patients in a supine position and deep into the muscle.

For intravenous administration, the first dose must be diluted with 0.9% sodium chloride solution or 5% dextrose solution in a 1:1 ratio. The drug should, if possible, be administered by infusion.

IV injections should be administered slowly (over 5 minutes).

Side effect

• headache;
• tinnitus;
• stomatitis;
• diarrhea;
• vomit;
• heartburn;
• nausea;
• drop in blood pressure;
• tachycardia;
• development of pulmonary hemorrhage as a manifestation of a hypersensitivity reaction;
• bronchospasm (mainly in patients with a hyperreactive bronchial system with bronchial asthma);
• skin rash;
• hives.

Contraindications

• peptic ulcer of the stomach and duodenum in the acute phase;
• hemoptysis;
• pulmonary hemorrhage;
• pregnancy;
• lactation period (breastfeeding);
• children under 2 years of age (the drug is in the form of granules for the preparation of a solution for oral administration /orange/ 100 mg and 200 mg, syrup and ACC 200);
• children under 6 years of age (the drug is in the form of granules for the preparation of a solution for oral administration, 200 mg);
• children under 14 years of age (the drug in the form of granules for the preparation of a solution for oral administration 600 mg and ACC Long);
• hypersensitivity to acetylcysteine ​​and other components of the drug.

Use during pregnancy and breastfeeding

Due to insufficient data, the use of the drug during pregnancy is contraindicated.

For syrup: use of the drug during pregnancy is possible only if the expected benefit to the mother outweighs the potential risk to the fetus.

If it is necessary to use the drug during lactation, the issue of stopping breastfeeding should be decided.

Use in children

Contraindicated for children under 2 years of age (the drug in the form of granules for the preparation of an oral solution /orange/ 100 mg and 200 mg, syrup and ACC 200), up to 6 years of age (the drug in the form of granules for the preparation of an oral solution 200 mg) , up to 14 years (the drug in the form of granules for the preparation of a solution for oral administration 600 mg and ACC Long).

Special instructions

For bronchial asthma and obstructive bronchitis, acetylcysteine ​​should be prescribed with caution under systematic monitoring of bronchial patency.

When using acetylcysteine, very rarely cases of severe allergic reactions such as Stevens-Johnson syndrome and Lyell's syndrome. If changes in the skin and mucous membranes occur, the patient should immediately stop taking the drug and consult a doctor.

When dissolving the drug, it is necessary to use glass containers and avoid contact with metals, rubber, oxygen, and easily oxidized substances.

You should not take the drug immediately before bedtime (the preferred time of administration is before 18.00).

If side effects develop, you should stop taking the drug.

ACC (in the form of granules for the preparation of solution for oral administration / orange / 100 mg and 200 mg) 100 mg corresponds to 0.24 XE, 200 mg - 0.23 XE.

Impact on the ability to drive vehicles and operate machinery

Information about the effect of the drug on the ability to drive vehicles and potentially engage in others dangerous species activities requiring increased concentration attention and speed of psychomotor reactions are absent.

Drug interactions

With the simultaneous use of acetylcysteine ​​and antitussives, dangerous mucus stagnation may occur due to suppression of the cough reflex (use the combination with caution).

When taking ACC with vasodilators and nitroglycerin simultaneously, the vasodilator effect may be enhanced.

There is a synergism between acetylcysteine ​​and bronchodilators.

ACC is pharmaceutically incompatible with antibiotics (penicillins, cephalosporins, erythromycin, tetracycline and amphotericin B) and proteolytic enzymes.

Acetylcysteine ​​reduces the absorption of cephalosporins, penicillins and tetracycline, so they should be taken orally no earlier than 2 hours after taking acetylcysteine.

When acetylcysteine ​​comes into contact with metals and rubber, sulfides with a characteristic odor are formed.

Analogues of the drug ACC

Structural analogues according to active substance:

• N-AC-ratiopharm;
• N-acetylcysteine;
• Acestine;
• Acetylcysteine;
• Acetylcysteine ​​SEDICO;
• Acetylcysteine ​​solution for inhalation 20%;
• Acetylcysteine ​​solution for injection 10%;
• Mukobene;
• Mucomist;
• Mukonex;
• N-AC-ratiopharm;
• Fluimucil;
• Exomyuk 200.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.