ACC

Compound

Effervescent tablets: acetylcysteine ​​and auxiliary components ( ascorbic acid, sucrose, saccharin, flavoring).

Powder: acetylcysteine ​​and auxiliary components (sucrose).

ACC Long effervescent tablets: acetylcysteine ​​and auxiliary components (ascorbic acid, sodium citrate, saccharin, sodium cyclamate, lactose, citric acid, sodium carbonate, mannitol, sodium bicarbonate, flavoring).

ACC for children: acetylcysteine.

Pharmacological action

The active substance is acetylcysteine, a derivative of cysteine ​​(amino acid). It has a mucolytic, expectorant effect due to the rupture of bisulfide bonds of sputum mucopolysaccharides. This depolymerizes mucoproteins and reduces the viscosity of bronchial secretions. As a result, mucociliary clearance increases and sputum discharge improves. Acetylcysteine ​​has an antioxidant and pneumoprotective effect, which is associated with the binding properties of sulfhydryl groups. Is an antidote for acute poisoning aldehydes, paracetamol and phenols (detoxifying effect is possible due to increased glutathione production).

When used internally, acetylcysteine ​​is almost immediately completely absorbed from gastrointestinal tract. The active metabolite is cysteine, which is formed in the liver. Further, the metabolism of acetylcysteine ​​passes through the formation of diacetylcysteine, cystine. The final product of metabolism is mixed disulfides.

Bioavailability is 10%. Cmax is determined after internal use after 1-3 hours. Plasma proteins bind 50% of acetylcysteine. The maximum concentration of the pharmacologically active metabolite in the blood is 2 µmol/l.

Inactive metabolites are excreted in the urine (inorganic sulfates, diacetylcysteine), but a small amount of acetylcysteine ​​is excreted unchanged in the feces.

The half-life of acetylcysteine ​​depends on biotransformation in the liver. At liver failure it lasts 8 hours, whereas normally it is 1 hour. It passes through the hematoplacental barrier and can accumulate in amniotic fluid.

Indications for use

Acetylcysteine ​​is prescribed in all cases of diseases with accumulation in bronchial tree and upper respiratory tract thick viscous sputum, namely:
Spicy and chronic bronchitis, including obstructive;
Bronchiolitis;
Tracheitis;
Bronchial asthma;
Bronchiectasis;
Cystic fibrosis;
Laryngitis;
Sinusitis;
Exudative otitis media.

Directions for use

The daily dose for the treatment of cystic fibrosis in patients weighing more than 30 kg is used up to 800 mg. Children from the 10th day of life to 2 years of age are given 50 mg 2-3 r/s. At the age of 2-5 years – 400 mg per day, divided into 4 doses. From 6 years – 600 mg/s (divided into 3 doses). Treatment is continued for a long time, in courses of several months (3-6).
In all other cases daily dose for children over 14 years of age and adults is 400-600 mg. From 6 to 14 years – 300-400 mg (divided into 2 doses), 2-5 years – 200-300 mg (divided into 2 doses). Children from the 10th day of life to 2 years of age are treated with 50 mg 2-3 r/s. At acute diseases without complications, the drug is prescribed for 5-7 days. In case of complications or chronic course Maybe course treatment(up to 6 months).

ACC is taken after meals. The tablet or contents of the sachet must be dissolved in half a glass of liquid (iced tea, water, juice).

Side effects

From the gastrointestinal tract - stomatitis, nausea, vomiting, diarrhea, heartburn.
From the side of the central nervous system - headache, tinnitus.
From the SSS side - arterial hypotension, increased heart rate.

Allergic reactions - bronchospasm (especially with bronchial hyperreactivity), rash and itching of the skin. Often the cause of hypersensitivity to the drug is the presence of propyl and methyl parahydroxybenzoate in the composition.

Contraindications

Hypersensitivity to acetylcysteine ​​and excipients
Peptic ulcer
Hereditary fructose intolerance
Pulmonary hemorrhage or hemoptysis
IN pediatric practice– for hepatitis and renal failure(threat of accumulation of nitrogen-containing products).

Pregnancy

Acetylcysteine ​​has no embryotoxic effect, however, during pregnancy, as well as during breastfeeding it is prescribed only if indicated under the supervision of a physician.

Drug interactions

Tetracycline and its derivatives (except doxycycline) should not be used together with ACC in pediatrics.
During experimental in vitro studies, no cases of inactivation of other species were identified antibacterial drugs. However, it is recommended to maintain a gap of at least 2 hours between taking the ACC and the antibiotic. In vitro, the incompatibility of acetylcysteine ​​with semisynthetic penicillins, aminoglycoside and cephalosporin antibiotics has been proven. Such studies have not been conducted with erythromycin, amoxicillin and cefuroxime.

The simultaneous use of antitussive drugs can lead to stagnation of respiratory tract secretions.

Use with nitroglycerin may increase vasodilator effect the last one.

Overdose

Cases of hypersecretion in children have been described in pediatric practice. infancy. Side effects that threaten life and health are not described. In case of overdose (dyspeptic disorders), symptomatic therapy is prescribed.

Release form

ACC 100, 200 - effervescent tablets, 20 pcs.
ACC hot drink – powder for preparing a hot drink for internal use- 200 mg (20 sachets) and 600 mg (6 sachets).
ACC-long – effervescent tablets (600 mg), 10 pcs. in the tube.
ACC powder for the preparation of solution for oral administration – 100, 200 mg, 2 pcs. in packaging.

ACC for children - powder for preparing a solution for internal use, 30 g in a 75 ml bottle (20 mg/ml) and 60 g in a 150 ml bottle (20 mg/ml).

Storage conditions

In places inaccessible to children. Temperature no more than 30°C. Ready solution can be stored for no more than 12 days in the refrigerator (at a temperature of 2-8°C).

Nosological classification (ICD-10)

Acute sinusitis (J01)

Acute obstructive laryngitis [croup] and epiglottitis (J05)

Bacterial pneumonia, not elsewhere classified (J15)

Acute bronchitis (J20)

Chronic sinusitis (J32)

Chronic laryngitis and laryngotracheitis (J37)

Chronic bronchitis, unspecified (J42)

For a better mucolytic effect, you should take plenty of fluids when treating with acetylcysteine.

10 ml ready oral solution contain 0.31 carbohydrate unit what should be taken into account by patients with diabetes mellitus.

Sorbitol has a slight laxative effect on stool.

For newborns and children under 1 year of age, acetylcysteine ​​is used exclusively for vital signs under strict medical supervision. The recommended dosage (10 mg/kg body weight) cannot be changed.
ACC 200 is not used for children under 2 years of age.
ACC Long is not recommended for children under 14 years of age.

The speed of reaction when driving and working with machinery does not change when taking acetylcysteine.

Authors

Attention!
Description of the drug " ACC"on this page is a simplified and expanded version official instructions by application. Before purchasing or using the drug, you should consult your doctor and read the instructions approved by the manufacturer.
Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.

ACC syrup is effective medicine, which is used to treat cough in childhood. The drug works carefully, so it has a minimum of contraindications. It is used to cleanse the bronchi and normalize function respiratory system. To quickly achieve the intended therapeutic effect, the instructions for the ACC syrup for children must be followed, which contains information regarding the duration of treatment, dosages for each age, side effects and contraindications for use.

Composition of children's cough medicine

Children's cough syrup is an effective medicine that is easy to give to your child. The drug has a liquid consistency and sweet taste, so most children take it without problems.

The syrup contains chemical compound acetylcysteine. By its structure, it is an amino acid that is included in metabolic processes and has a mucolytic effect on the child’s body.

In other words, the medicine helps make the mucus in the bronchi more liquid and speed up the release of mucus from the airways.

To improve the taste, the manufacturer included cherry flavoring in the syrup. Any hazardous substances, including ethanol or dyes, are not among the ingredients of the medicine. This means that the syrup can be safely given to children.

"ACC" for children in liquid form is available in bottles made of dark thick glass. Each container is equipped with a cap to prevent accidental opening by children. The manufacturer offers two options - 100 ml and 200 ml. Each product package contains detailed instructions, measuring cap and syringe for quickly drawing up syrup.

Pharmacological properties and pharmacokinetics

Acetylcysteine ​​from medicinal product enters the baby's gastrointestinal tract and is absorbed into systemic blood flow from small intestine. Next, the active substance is transported to respiratory tract, where he begins to work. In this case, the impact is carried out in three directions at once.

1. In the branches of the bronchi, acetylcysteine ​​acts on disulfide bonds in sputum molecules. As a result, they are destroyed, and the mucus itself becomes more liquid and leaves the respiratory tract more easily, without lingering on their inner walls.
2. The product does more than just liquefy mucus. It protects the body from inflammatory processes. Acetylcysteine ​​plays the role of an antioxidant, protecting tissues and cells from free radicals, the concentration of which increases during illness.
3. Acetylcysteine ​​is able to suppress the excessive activity of paracetamol, therefore it can protect the child’s body from intoxication with this drug.

The spent drug is metabolized in the liver tissues. In gland cells, the active substance is transformed into cysteine ​​and cystine, as well as their derivatives. Later they leave the child’s body in urine.

For which cough is the medicine prescribed?

“ACC” in the form of syrup perfectly reduces the viscosity of sputum, so the drug is prescribed for wet coughs. It will help even if the sputum comes out extremely slowly or if it contains impurities of pus.

The main indications for the use of children's cough syrup are:

• laryngitis;
• bronchitis;
• pneumonia;
• lung abscess;
• COPD;
• cystic fibrosis.

According to doctors, “ACC” will become one of key elements therapy for the listed diseases, however, in some cases, taking the medication will not have the desired effect.

It makes no sense to take "ACC" for nasopharyngitis - a condition in which the cough becomes a consequence of a runny nose and not the accumulation of mucus in the bronchi.

In this case, it is important to address the cause of the symptom.

Instructions for use of ACC cough syrup for children

Syrup "ACC" – excellent remedy to cleanse the bronchi, which must be used strictly according to the scheme suggested by the doctor. When selecting the optimal dose, the patient's age is taken into account.

1. For children from 2 to 5 years old, pediatricians prescribe 5 ml of syrup 2 or 3 times a day.
2. Children under 14 years of age can take the medicine twice a day, 10 ml.
3. Teenagers over 14 years old can drink 10 ml of “ACC” three times.

Please note that 1 ml of the drug contains 20 mg active substance. General daily norm for children under 5 years of age should not exceed 300 mg of acetylcysteine. For older children, this threshold is higher (400 mg if the child is from 6 to 14 years old, and 600 mg for adolescents).

Take "ACC" cough syrup for children immediately after meals. During treatment it is necessary to ensure drinking plenty of fluids. This measure will enhance the thinning effect and allow you to quickly eliminate the unpleasant symptom.

The duration of the entire course of therapy will be determined by the doctor. Typically, “ACC” in liquid form is prescribed for 5–7 days, but a positive effect is observed already on the third day. An exception is the treatment of cystic fibrosis. In this case you will need long-term use medications to prevent sudden exacerbations.

Important! An opened bottle must be used during one course of therapy. The medicine will be useful only for 10 days.

This is worth paying attention to when choosing the right volume. It must be stored in the refrigerator.

Drug interactions

"ACC" is prescribed for treatment wet cough for pathologies of the lower respiratory tract. Such conditions often require taking other medications, in particular antipyretic or anti-inflammatory medications. The drug containing acetylcysteine ​​does not reduce their effectiveness, so it can be used without restrictions.

Doctors inform that ACC cannot be taken simultaneously with any medications designed to cure dry cough. Such medications block the reflex center. As a result, the cough is suppressed, but sputum still continues to accumulate in the lungs, which can provoke its stagnation and subsequent inflammatory process.

In addition, ACC should be taken with caution with penicillin or tetracycline antibiotics. There is a possibility that the cough medicine will reduce the antimicrobial effect and treatment will be delayed. To avoid this, you need to take a two-hour break between taking ACC and the antibiotic.

Contraindications, side effects and overdose

"ACC" should be taken strictly in the dosage suggested by the doctor. Otherwise, instead of expected quick recovery side effects will develop.

The most common ones include:

• headache;
• tinnitus;
• nausea;
• diarrhea;
• skin rashes;
• swelling.

In cases of overdose, the listed side effects will be most pronounced, however, clinical studies confirm that intoxication medicine was not observed even when consumed by healthy people.

"ACC", like all medications, has its contraindications.

The syrup should not be taken if:

• high sensitivity to the active substance;
• stomach ulcer in acute form;
• bleeding in the lungs.

Analogues of ACC syrup

"ACC" is not the most cheap drug for cough. Average price for a bottle of 100 ml – 240 rubles, and for a volume of 200 ml – 350 rubles. In some cases, a pharmaceutical drug can be replaced by similar drugs with the same active ingredient. Many of these products are cheaper, but work exactly the same. To the list of medications with similar composition include "Fluimucil" or "Acetylcysteine". They are produced in the form of granules, which require preliminary dilution in warm water.

Sometimes doctors prescribe other drugs that contain ambroxol. It also thins phlegm and frees the bronchi from viscous mucus. The most known drugs from this group are the Lazolvan and Ambrobene syrups. They are in the same price category as "ACC".

Older children can consider taking the drug "ACC", but not in the form of syrup, but in the form effervescent tablets or powder for dissolution in water. This medicine has an orange flavor, so children drink it without problems.

The final decision on prescribing any drug is always made by the doctor. The pediatrician will examine the child and decide which remedy will most quickly relieve unpleasant symptoms. Syrup "ACC" – great option for children over two years of age suffering from a productive cough.

Instructions for use

ACC instructions for use

Dosage form

The syrup is transparent, colorless, slightly viscous, with a cherry smell.

Compound

Acetylcysteine ​​20 mg

Excipients: methyl parahydroxybenzoate - 1.3 mg, sodium benzoate - 1.95 mg, disodium edetate - 1 mg, sodium saccharinate - 1 mg, sodium carmellose - 2 mg, sodium hydroxide (10% aqueous solution) - 30-70 mg, "Cherry" flavoring - 1.5 mg, purified water - 910.25-950.25 mg.

Pharmacodynamics

Mucolytic agent. It thins mucus, increases its volume, facilitates secretion, and promotes expectoration. The action of acetylcysteine ​​is associated with the ability of its sulfhydryl groups to break the disulfide bonds of acidic mucopolysaccharides of sputum, which leads to depolarization of mucoproteins and a decrease in mucus viscosity. Remains active in the presence of purulent sputum.

It has an antioxidant effect due to the presence of an SH group that can interact with and neutralize electrophilic oxidative toxins. Acetylcysteine ​​helps increase the synthesis of glutathione, which is an important antioxidant factor in intracellular protection and ensures the maintenance of functional activity and morphological integrity of the cell.

Pharmacokinetics

When taken orally, it is well absorbed from the gastrointestinal tract. It is largely subject to the “first pass” effect through the liver, which leads to a decrease in bioavailability. Binding to plasma proteins up to 50% (4 hours after oral administration). Metabolized in the liver and possibly in intestinal wall. In plasma it is determined unchanged, as well as in the form of metabolites - N-acetylcysteine, N,N-diacetylcysteine ​​and cysteine ​​ester.

Renal clearance accounts for 30% of the total clearance.

Side effects

From the outside digestive system: rarely - heartburn, nausea, vomiting, diarrhea, feeling of fullness in the stomach.

Allergic reactions: rarely - skin rash, itching, urticaria, bronchospasm.

With shallow intramuscular injection and in the presence of increased sensitivity, a slight and quickly passing burning sensation may occur, and therefore it is recommended to inject the drug deep into the muscle.

At inhalation use: possible reflex cough, local irritation of the respiratory tract; rarely - stomatitis, rhinitis.

Other: rarely - nosebleeds, rarely - tinnitus.

From the outside laboratory parameters: possible decrease in prothrombin time due to prescription large doses acetylcysteine ​​(monitoring of the state of the blood coagulation system is necessary), changes in test results quantification salicylates (colorimetric test) and ketone quantitation test (sodium nitroprusside test).

Selling Features

Available without a prescription

Special conditions

Acetylcysteine ​​is used with caution in patients with bronchial asthma, diseases of the liver, kidneys, and adrenal glands. When using acetylcysteine ​​in patients with bronchial asthma, it is necessary to ensure sputum drainage. In newborns, it is used only for health reasons at a dose of 10 mg/kg under the strict supervision of a physician.

A 1-2 hour interval should be observed between taking acetylcysteine ​​and antibiotics.

Acetylcysteine ​​reacts with some materials such as iron, copper and rubber used in the spray device. In places of possible contact with acetylcysteine ​​solution, parts made of the following materials should be used: glass, plastic, aluminum, chromed metal, tantalum, sterling silver or stainless steel. After contact, the silver may tarnish, but this does not affect the effectiveness of acetylcysteine ​​and does not cause harm to the patient.

Indications

Respiratory diseases and conditions accompanied by the formation of viscous and mucopurulent sputum: acute and chronic bronchitis, tracheitis due to bacterial and/or viral infection, pneumonia, bronchiectasis, bronchial asthma, atelectasis due to blockage of the bronchi by mucus plugs, sinusitis (to facilitate the passage of secretions), cystic fibrosis (as part of combination therapy).

Removal of viscous secretions from the respiratory tract in post-traumatic and postoperative conditions.

Paracetamol overdose.

Contraindications

Gastric ulcer and duodenum in the acute phase, hemoptysis, pulmonary hemorrhage, increased sensitivity to acetylcysteine.

Use during pregnancy and breastfeeding

Adequate and strictly controlled clinical trials The safety of acetylcysteine ​​during pregnancy and lactation has not been studied.

During pregnancy and lactation, the use of acetylcysteine ​​is possible only if the expected benefit to the mother outweighs the potential risk to the fetus or infant.

Use for liver dysfunction

Acetylcysteine ​​should be used with caution in patients with liver disease.

Use for renal impairment

Acetylcysteine ​​should be used with caution in patients with kidney disease.

Use in children

When using acetylcysteine ​​in patients with bronchial asthma, it is necessary to ensure sputum drainage. In newborns, it is used only for health reasons at a dose of 10 mg/kg under the strict supervision of a physician.

Orally for children over 6 years old - 200 mg 2-3 times a day; children aged 2 to 6 years - 200 mg 2 times / day or 100 mg 3 times / day, up to 2 years - 100 mg 2 times / day.

Drug interactions

The simultaneous use of acetylcysteine ​​with antitussives may increase sputum stagnation due to suppression of the cough reflex.

When used simultaneously with antibiotics (including tetracycline, ampicillin, amphotericin B), their interaction with the thiol group of acetylcysteine ​​is possible.

Acetylcysteine ​​reduces the hepatotoxic effect of paracetamol.

Prices for ACC in other cities

Buy ACC,

You are a fairly active person who cares and thinks about your respiratory system and health in general, continue to play sports, lead healthy image life and your body will delight you throughout your life. But do not forget to undergo examinations on time, maintain your immunity, this is very important, do not overcool, avoid severe physical and strong emotional overload. Try to minimize contact with sick people; if forced contact, do not forget about protective equipment (mask, washing your hands and face, clearing your respiratory tract).

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You are at risk, you should think about your lifestyle and start taking care of yourself. Physical education is required, or even better, start playing sports, choose the sport that you like most and turn it into a hobby (dancing, cycling, gym or just try to walk more). Do not forget to treat colds and flu promptly, they can lead to complications in the lungs. Be sure to work on your immunity, strengthen yourself, be in nature as often as possible and fresh air. Do not forget to undergo scheduled annual examinations, treat lung diseases initial stages much simpler than in a neglected form. Avoid emotional and physical stress; if possible, eliminate or minimize smoking or contact with smokers.

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