Compound medicinal product NO-SHPA

NO-SHPA®

tab. 40 mg, № 20 UAH 6.81

tab. 40 mg, № 100 UAH 20.38

Drotaverine hydrochloride 40 mg

Other Ingredients: Magnesium stearate, talc, lactose, corn starch, povidone.

No. P.01.03/05723 from 10.01.2003 to 10.01.2008

rr d / in. 40 mg amp. 2 ml, № 25 UAH 42.82

Drotaverine hydrochloride 20 mg/ml

Other Ingredients: Sodium Metabisulphite, Ethyl Alcohol 96%, Water for Injection.

No. P.01.03/05724 from 17.08.2007 to 17.08.2011

NO-SHPA® FORTE

tab. 80 mg, #10

tab. 80 mg, № 20 UAH 12.31

Drotaverine hydrochloride 80 mg

Other Ingredients: Magnesium stearate, talc, povidone, corn starch, lactose.

Dosage form

tablets

Pharmacological properties

drotaverine - antispasmodic, an isoquinoline derivative, acts directly on smooth muscle by inhibiting phosphodiesterase and intracellular cAMP accumulation, resulting in smooth muscle relaxation through inactivation of the myosin kinase light chain. The antispasmodic effect of drotaverine does not depend on the nature autonomic innervation, the drug is active against smooth muscles of the gastrointestinal, biliary, urogenital and cardiovascular vascular systems.

Drotaverine is rapidly absorbed both parenterally and orally. The maximum concentration in blood serum is reached in 45-60 minutes after oral administration. Metabolized in the liver. The half-life is 16–22 hours. In 72 hours, it is almost completely excreted from the body, about 50% in the urine, 30% in the feces. Basically - in the form of metabolites, unchanged in the urine is not determined. Drotaverine and / or its metabolites practically do not penetrate the placental barrier.

Indications for use NO-ShPA

No-Shpa

Spasms of smooth muscles caused by diseases biliary tract- cholelithiasis, cholangiolithiasis, cholecystitis, pericholecystitis, cholangitis, papillitis; to reduce the phase of cervical dilatation of physiological labor and the duration of labor; in the placental stage of labor to facilitate the implementation of the reception of Crede and the prevention of incarceration; spasms of smooth muscles of the urinary tract with nephrolithiasis, urethrolithiasis, pyelitis, cystitis, tenesmus Bladder. The drug can be used as an adjuvant therapy for spasms of smooth muscles of organs digestive tract- with peptic ulcer of the stomach and / or duodenum, gastroduodenitis, enteritis, spastic colitis, cardiospasm and pyloric spasm, irritable bowel syndrome, spastic constipation, flatulence, pancreatitis; at gynecological diseases- dysmenorrhea, adnexitis, severe painful labor pains, uterine tetany, threatened abortion; with headache of vascular origin.

No-Shpa Forte

Spasms of smooth muscles caused by diseases of the biliary tract, cholelithiasis, cholangiolithiasis, cholecystitis, pericholecystitis, cholangitis, papillitis. Spasms of smooth muscles of the urinary tract with nephrolithiasis, urethrolithiasis, pyelitis, cystitis, bladder tenesmus. The drug is effective and safe when used as an adjuvant therapy for smooth muscle spasms of the gastrointestinal tract - peptic ulcer of the stomach and duodenum, gastritis, enteritis, colitis, cardiospasm and pyloric spasm, irritable bowel syndrome, spastic constipation or flatulence, pancreatitis; with gynecological diseases - dysmenorrhea, adnexitis; with headache of vascular origin.

Contraindications

hypersensitivity to drotaverine or any component of the drug, severe hepatic, renal or heart failure (small cardiac output). Lactase deficiency, galactosemia, or glucose/galactose malabsorption syndrome. breastfeeding period. Children under the age of 1 year.

Usage Precautions

the drug can cause dyspepsia in patients with lactose intolerance due to its content in tablets. At arterial hypotension apply with caution. In / injected only in the supine position (risk of collapse). When hypersensitivity to sodium metabisulphite should be avoided parenteral use drug. After parenteral, especially intravenous administration of the drug, it is recommended to refrain from administration for 1 hour vehicles and performance of tasks that require increased attention.

The experiment did not establish the presence of a teratogenic and embryotoxic effect in the drug. Does not affect the course of pregnancy. During lactation, the drug should be prescribed taking into account the ratio of risk and benefit.

Interaction with drugs

care must be taken while using No-Shpa with levodopa, since the anti-Parkinsonian effect of the latter is reduced and there is an increase in tremor and rigidity.

Method of application and dosage NO-ShPA

No-Shpa

Adults inside - 120-240 mg / day in 2-3 doses. With attacks of kidney or hepatic colic 40-80 mg (2-4 ml) is slowly (over 30 s) injected intravenously, usually in combination with analgesics. In other spastic conditions, it is administered intramuscularly or s / c at a dose of 40–80 mg, if necessary, it is administered at the same dose again up to 3 times a day, or subsequently administered orally at a daily dose of 120–240 mg.

To alleviate cervical dilatation during childbirth, it is administered at a dose of 40 mg / m at the beginning labor activity. If this dose is ineffective, repeat the same dose after 2 hours.

Children aged 1 year - 6 years inside - 40-120 mg / day (2-3 times 1/2-1 tablet), over 6 years old - 80-200 mg / day (2-5 times 1 tablet).

Side effects

side effects, noted at clinical research and caused by taking drotaverine, classified by organs and systems, as well as by frequency of occurrence: very often (≥1/10), often (≥1/100, but
Gastrointestinal disorders: rarely - nausea, constipation.

From the side nervous system:rarely - headache, dizziness, insomnia.

From the side of cardio-vascular system: rarely - tachycardia, arterial hypotension.

Self-medication can be harmful to your health.
It is necessary to consult a doctor, and also read the instructions before use.

NO-ShPA forte tablets: instructions for use

Compound

One tablet contains:

Active substance: drotaverine hydrochloride 80 mg.

Excipients:

Magnesium stearag 6.0 mg

Telc 8.0 mg

Povidone 12.0 mg

Corn starch 70.0 mg

Lactose monohydrate 104.0 mg.

pharmachologic effect

Pharmacotherapeutic group: agents used in violation of bowel function. ATX code: A03AD02

Indications for use

* spasms of smooth muscles associated with diseases of the biliary tract: cholecystolithiasis, cholangiolithiasis, cholecystitis, pericholecystitis, cholangitis, papipitis;

* smooth muscle spasms urinary tract: nephrolithiasis, urethrolithiasis, pyelitis, cystitis, bladder tenesmus.

* with spasms of smooth muscles of gastrointestinal origin: peptic ulcer stomach and duodenum, gastritis, spasms of the cardia and pylorus, enteritis, colitis, spastic colitis with constipation and meteoristic forms of mucous colitis;

* Tension-type headaches (headaches muscle tension, psychogenic, stress, chronic daily headache, transformed migraine);

* in obstetrics and gynecology: with painful periods, to reduce the excitability of the uterus during pregnancy, with threatened abortion.

Contraindications

* hypersensitivity to the active substance or to any of the excipients of the drug;

* severe hepatic or kidney failure;

* severe heart failure;

*Children under 6 years of age.

Pregnancy and lactation

As shown by animal reproduction experiments and retrospective studies of clinical data, oral administration Drotaverine during pregnancy does not affect the fetus and its development. However, when prescribing the drug during pregnancy, caution is necessary.

Due to the lack of necessary clinical data during lactation, it is not recommended to prescribe.

Dosage and administration

adults: Plain daily dose is 120 - 240 mg, i.e. 1.5-3 tablets per day, to be taken in 2-3 divided doses. Single dose for adults 40-80 mg (0.5 - 1 tablet).

Children over 6 years old: The usual daily dose is 80-200 mg, i.e. 1-2.5 tablets per day, to be taken in 2-5 doses. Single dose for children over 6 years of age 40 mg (0.5 tablets).

Side effect

. from the gastrointestinal tract: rarely: nausea, constipation

from the nervous system: rarely: headache, dizziness, insomnia

from the cardiovascular system:

rare: palpitations, decrease blood pressure. In case of occurrence side effects it is necessary to stop taking the drug.

In case of side effects that are not mentioned in the instructions, it is necessary to inform the attending physician about this.

Overdose

No cases of overdose of drotaverine have been reported.

Interaction with other drugs

Care must be taken when joint application drug with levodopa, since the antiparkinsonian effect of the latter is reduced and there is an increase in tremor and rigidity.

Application features

Influence on the ability to drive a car and perform work requiring increased attention:

If dizziness occurs, avoid potentially dangerous actions such as driving vehicles and working on machines.

Precautionary measures

With hypotension, the use of the drug requires caution. The drug contains 104 mg of lactose. When taken according to the recommended dosage, each dose contains up to 156 mg of lactose. It can cause gastrointestinal complaints in individuals suffering from lactose intolerance.

This form is unacceptable for patients suffering from lactose deficiency, galactosemia or impaired glucose / galactose absorption syndrome.

"No-shpa" is a drug that has antispasmodic and vasodilating effects. With this drug, you can lower the tone of smooth muscles and muscles internal organs. In its action, it surpasses its analogues. At the same time, such strong action this drug is not negative factor for the work of the central and autonomic nervous system.

When taking this drug, its active substance - drotaverine acts only on the muscles of the internal organs. Therefore, this antispasmodic is used in the treatment of patients who are contraindicated in drugs - anticholinergics.

The effect of taking this drug occurs within a few minutes. After half an hour, the phase of the maximum effect from taking this antispasmodic begins.

No-shpa release forms

Each form contains active substance- drotaverine, as well as some additional compounds: talc, lactose, corn starch, etc.

Tablets

• The tablet form of "No-shpy" is presented in the form of orange or yellow-green biconvex pills with the letters "spa" on one of their sides. One tablet contains 40 mg of drotaverine hydrochloride
• Tablets are indicated for muscle spasms in diseases such as: cholecystitis, cholecystolithiasis, cholangitis, papillitis, cystitis, cystitis, uro- and nephrolithiasis, pyelitis and bladder tenesmus
• Also, No-shpa tablets are used to relieve spasms in diseases of the stomach and intestines, as an anesthetic for headaches caused by spasm of blood vessels

Solution

The use of this drug in ampoules is indicated if taking tablets, according to various reasons impossible

• No-shpa solution does not contain lactose. Therefore, it can be used to relieve spasms in patients with intolerance to this carbohydrate.
• Injections with this drug are prescribed for patients with impaired glucose absorption syndrome, galactosemia and lactose deficiency.
• With pancreatitis complicated by strong gag reflexes, only injections of this drug can also be used.

No-shpa indications for use

The instruction for this drug says that it is necessary to use "No-shpu" in the event of spasmolytic pain caused by:

• Urolithiasis
• Peptic ulcer of the stomach and duodenum
• Chronic cholecystitis
• Postoperative spasms
• Violations of the duct of the vessels of the head

No-shpa dosage

It is necessary to use this drug in strictly prescribed dosages.

• For adults, 120 - 240 mg of this remedy is shown per day. It must be taken 2-3 times. At one time, you can take no more than 80 mg of this antispasmodic
• The daily intake intravenous solution"No-shpa" is 40-240 mg. Single dosage 40-80 mg. It is possible to use three injections of this drug per day with 2-3 hours between them.
• It is possible to take "No-shpu" on your own for no more than two days in a row. If the drug does not give the desired effect, you should seek help from a qualified specialist.

No-shpa for children

• Children under one year of age should not take this medicine. Although many mothers ignore this instruction and give "No-shpa" to infants with intestinal colic
• As a rule, no negative consequences such reception of this drug does not cause. in minimal quantities, active substance this antispasmodic, mixed with mother's milk, has a "soft" effect. But, it is better to consult a doctor before taking this.
• Children from 1 to 6 years old can use "No-shpu" in the amount of 40 - 200 mg of the drug for 2-3 doses. Accurate dosage the doctor will tell

Children over 6 years old can use this remedy in the amount of 80-200 mg for 2-5 doses.

IMPORTANT: Do not give "No-shpu" to a child who is lactose intolerant and allergic to drotaverine.

No-shpa side effects

The most severe negative reactions when taking this antispasmodic were recorded when it was administered as an injection.

No-shpa contraindications

You can not take this antispasmodic for glaucoma and hypersensitivity to its components

No-shpa overdose

• When taking this antispasmodic over allowable rate induce vomiting and gastric lavage
• At the same time, it is urgent to provide clinical control to the affected person and carry out symptomatic and supportive therapy.

No-shpa during pregnancy

Carrying a child is a very important stage in the life of every woman.

• And the main task is right choice medicines to treat problems that arise during this period. They must be effective and at the same time not harm the unborn child.
• Experts have proven that taking "No-shpy" during pregnancy cannot harm the child and recommend using this remedy to remove increased tone uterus
• Therefore, all women who are carrying a child should always have this drug on hand.

No-shpa or Papaverine

• Both drugs are myotropic antispasmodics. They are able to reduce muscle tone and expand blood vessels. This relieves muscle spasms
• In terms of severity of action and effectiveness, "No-shpa" surpasses "Papaverine" several times. It is also important to know that "Papaverine" is poorly soluble in the aquatic environment.
• Therefore, it is more effective to take it intravenously or rectally. As for the No-shpa tablets, their intake is not complicated by this. They can be taken at any time. As a rule, these tablets are always at hand.

Analogues

"Drotaverine hydrochloride". Tablets with antispasmodic and vasodilating effects. They are used in the treatment of cholecystitis, pyelitis, stomach ulcers and spasms caused by other diseases.

• Dosage - 1-2 tablets 2-3 grooves per day

"Drotaverin Forte". Myotropic antispasmodic. Produced in the form of tablets. In terms of components and structure, it is close to Papaverine, but surpasses it in action and efficiency.

• Dosage - 1-2 tablets 1-3 times a day

"Spazmol". Myotropic antispasmodic based on drotaverine hydrochloride. Therefore, it has the same scope and effectiveness.

Spazmonet. Myotropic antispasmodic based on drotaverine hydrochloride. It is used for spasms of smooth muscles.

• Dosage - 1-2 tablets 2-3 times a day

Ekaterina. Always at acute pain I use "No-shpu". It works within 10-15 minutes. But, somehow, this medicine was not in the first-aid kit. I went to a neighbor, he said that instead of "No-shpa" he uses drotaverine. Gave it to me. Personally, it didn't work for me. I advise everyone only "No-shpu".

Sonya. The child got sick. I lay in bed with him, I see the handles became cold. I called my pediatrician. She said urgently to give "No-shpu". Half a pill. And so it did. After 20 minutes, the hands became warm again. I’m even afraid to think about what would have happened if it weren’t for the doctor’s advice and “No-shpa” in the first-aid kit.

Video: ALL ABOUT PILLS [Pain of various origins]

A drug based on a pronounced antispasmodic effect of a substance - drotaverine. In its action, drotaverine is close to papaverine, but its antispasmodic properties are stronger and it lasts much longer.

But - shpa relieves spasm of smooth muscles, and as a result, eliminates spasms of the walls of blood vessels, stomach and intestines, urinary organs, as well as organs included in reproductive system. To some extent, the drug depresses brain activity and upon admission to large doses- cardiac activity.

When administered intramuscularly, it causes a slight decrease in pressure. Intravenous administration achieves an increase in blood flow in the vessels lower extremities, although with intra-arterial administration this effect will be much more noticeable.

Unlike narcotic painkillers, but - shpa in no way masks a complex of symptoms, which is called " acute abdomen", which allows you to use it for pain different nature in the abdomen without fear to ignore, for example, an attack acute appendicitis.
When hit in intestinal tract, this drug is absorbed quite quickly, and to act but - the spa tablet will begin in about an hour. With intravenous (intra-arterial) administration of the drug, it starts within five minutes, with intramuscular administration - after about half an hour.

Instructions for use

The drug can be administered both intravenously and intramuscularly, and taken orally. In some cases, but-shpu is used intradermally. With a pronounced pain syndrome, which can be caused by a spasm of smooth muscles, but - shpu is administered intravenously, but extremely slowly, drip. Intravenous administration can alleviate the patient's condition with renal colic and pain in the liver and gallbladder, which often occur when the lumen of the passages is blocked by stones.

But - shpa helps with painful periods, due to the fact that the spasm of the smooth muscles of the uterus is noticeably reduced.

This effect allows you to use but - shpu during pregnancy, when the uterus is in good shape. Moreover, but - shpa during pregnancy does not have any harm to the unborn child. This drug is excellent for relieving pain and tension in the abdomen and can remove the threat of miscarriage. Pregnant women, especially those to whom doctors "put" the threat of termination of pregnancy, it is better to always have no-shpa tablets on hand.

But - shpa during childbirth turns out to be indispensable tool. Since it not only relieves pain during contractions, but also relieves spasms from the cervix, thereby contributing to its fuller and faster opening.

Due to the ability to relieve spasm of smooth muscles, but - shpa is successfully used in pediatric practice. But - shpa children can be prescribed after the age of six.

At the same time, but - shpa during breastfeeding also does not harm the child, in some cases, taking but - shpa by a nursing mother can alleviate the condition of a baby who is tormented by colic.
But - shpa application.

More often they take but - shpu in tablets. An adult is prescribed up to 0.08 g per day, and take 1 to 4 per day. During pregnancy maximum dose is 6 tablets per day.

If there is an acute pain syndrome but - shpu is administered intravenously in the amount of 3 - 4 ml of a 20% solution.

With a protracted, unrepairable attack of angina, analgin is administered and no-shpa 2 ml of each drug.
No-shpu is prescribed for children depending on their body weight, and also taking into account age, however single dose should not exceed 0.5 tablets. According to the appointment of a pediatrician, it is possible to receive but - spas starting from the age of three.

However, no matter how harmless this drug is, its appointment is possible only by the attending physician. In some cases, the drug but - shpa is completely useless. At the same time, the time spent waiting for the relief of a painful attack can be the cause of complications. Therefore, for pain, the cause of which is not clear, but - shpa can be used exclusively as a remedy first aid. As a means that can alleviate the condition of the patient until he can receive a qualified medical assistance.
Side effects and overdose.
But - shpa has side effects, which must be taken into account when taking.

First of all, these are allergic reactions of the body, expressed mainly by dermatitis.

In case of overdose when taken orally, weakness, constipation, dry mouth occur.

When too fast intravenous administration the drug may cause dizziness, drowsiness, a feeling of heat and even cardiac arrhythmia.

Nevertheless, the response to this drug from doctors and patients is consistently positive. This remedy is indeed very often the one magic wand- a lifesaver that will help in almost any situation.

Buy it medicine It is possible both on the Internet and in a regular pharmacy. But - shpa is produced in ampoules of 2 ml, and in the form of tablets of 0.04 gr.
But - shpa price
But - shpa 40 mg 100 tablets costs 200 rubles
But - shpa 2 ml 5 ampoules - 90 rubles.

Antispasmodic.

Preparation: NO-ShPA ®
Active ingredient: drotaverine
ATX code: A03AD02
KFG: Myotropic antispasmodic
Reg. number: P No. 011854/02
Date of registration: 02.09.05
The owner of the reg. acc.: CHINOIN Pharmaceutical and Chemical Works Private Co. Ltd. (Hungary)

PHARMACEUTICAL FORM, COMPOSITION AND PACKAGING

Tablets round, biconvex, yellow with a greenish or orange tint, marked "spa" on one side.

Excipients: magnesium stearate, talc, polyvidone, corn starch, lactose monohydrate.

10 pieces. - blisters (2) - packs of cardboard.
60 pcs. - polypropylene bottles with "push-top" dispenser (1) - packs of cardboard.
100 pieces. - polypropylene bottles (1) - cardboard packs.

Solution for intravenous and intramuscular administration transparent, greenish-yellow color.

Excipients: sodium metabisulphite, ethanol 96%, water for injection.

2 ml - dark glass ampoules (5) - plastic cell packaging (1) - cardboard packs.
2 ml - dark glass ampoules (5) - plastic cell packaging (5) - cardboard packs.

The description of the drug is based on the officially approved instructions for use.

PHARMACHOLOGIC EFFECT

Antispasmodic. Drotaverine is an isoquinoline derivative that exhibits an antispasmodic effect on smooth muscles by inhibiting the enzyme phosphodiesterase 4 (PDE 4). Inhibition of the PDE4 enzyme leads to increased concentration cAMP, which inactivates the myosin kinase (MLCK) light chain, which in turn leads to smooth muscle relaxation.

Drotaverine inhibits the PDE 4 enzyme in vitro without inhibiting the PDE 3 and PDE 5 isoenzymes. Apparently, PDE IV is functionally very important for reducing the contractility of smooth muscles, therefore, selective PDE 4 inhibitors can be effective in the treatment of hyperkinetic diseases and diseases associated with spastic conditions of the gastrointestinal tract .

The enzyme hydrolyzing cAMP in myocardial and vascular smooth muscle cells is mainly a PDE 3 isoenzyme, which explains high efficiency drotaverine as an antispasmodic in the absence of pronounced action on the cardiovascular system and serious cardiovascular adverse events. The drug is effective in spasms of smooth muscles of both nervous and muscular etiology. Regardless of the type of autonomic innervation, drotaverine acts on the smooth muscles of the gastrointestinal tract, biliary tract, as well as the genitourinary and vascular systems. Thanks to vasodilating action No-shpa improves blood circulation in tissues.

PHARMACOKINETICS

Suction and distribution

when taken orally and parenteral administration drotaverine is rapidly and completely absorbed. C max is achieved within 45-60 minutes. It binds to plasma proteins (alpha albumins and alpha and beta globulins).

Metabolism and excretion

Metabolized in the liver. T 1/2 - 16-22 hours. After 72 hours, drotaverine is excreted from the body mainly in the form of metabolites, 50% in the urine, 30% in the feces.

INDICATIONS

Spasms of smooth muscles associated with diseases of the biliary tract: cholelithiasis, cholecystitis, pericholecystitis, cholangitis, papillitis;

Spasms of the smooth muscles of the urinary system: urolithiasis disease, pyelitis, cystitis, bladder tenesmus;

At physiological childbirth- shortening the phase of cervical dilatation and thereby reducing the total duration of labor (for solution for intravenous and intramuscular injection);

As adjuvant therapy:

With spasms of smooth muscles of the gastrointestinal tract: peptic ulcer of the stomach and duodenum, gastritis, spasms of the cardia and pylorus, enteritis, colitis, accompanied by constipation and flatulence;

Tension headaches (for oral administration);

With gynecological diseases (dysmenorrhea);

Strong labor pains (for solution for intravenous and intramuscular administration);

When used as aid the drug is administered parenterally when it is impossible to use tablets.

DOSING MODE

Adults when taken orally, the recommended daily dose is 120-240 mg (in 2-3 doses); children the dose of the drug is set depending on age, for children aged from 1 to 6 years- 40-120 mg (in 2-3 doses); v over 6 years of age- 80-200 mg (in 2-5 doses).

The average daily dose for i / m administration in adults is 40-240 mg (divided into 1-3 injections / day). At acute colic (renal or biliary) the drug is administered intravenously at a dose of 40-80 mg.

For shortening of the dilatation phase of the cervix during physiological labor 40 mg is administered intramuscularly, which, if the effect is unsatisfactory, can be repeated 1 time for 2 hours.

SIDE EFFECT

From the side digestive system: rarely - nausea, constipation.

From the side of the central nervous system: rarely - headache, dizziness, insomnia.

From the side of the cardiovascular system: rarely - palpitations; very rarely - arterial hypotension.

Others: very rarely - allergic reactions (with parenteral administration, especially in patients with hypersensitivity to bisulfite).

CONTRAINDICATIONS

severe renal or hepatic insufficiency;

Severe heart failure (low cardiac output syndrome);

Children's age up to 1 year (for tablets);

Hypersensitivity to drotaverine or to any excipient the drug (especially to sodium metabisulphite - for a solution for intravenous and intramuscular administration).

WITH caution use the drug for arterial hypotension. When the / in the introduction of the drug, the patient should be in the supine position because of the risk of collapse.

PREGNANCY AND LACTATION

Drotaverine does not have teratogenic and embryotoxic effects. However, the use of the drug is recommended only after careful weighing of the ratio of the expected benefits and possible risks.

Due to the lack of necessary clinical data, drotaverine is not recommended for use during lactation (breastfeeding).

SPECIAL INSTRUCTIONS

The composition of the tablets includes 52 mg of lactose, therefore it is not prescribed for patients with lactase deficiency, galactosemia or impaired glucose / galactose absorption syndrome.

The solution for intravenous and intramuscular injection contains sodium bisulfite, which can cause allergic reactions, including anaphylactic and bronchospasm, in sensitive individuals (especially in people with bronchial asthma or allergic reactions in history). In case of hypersensitivity to sodium metabisulphite, parenteral use of the drug should be avoided.

Influence on the ability to drive vehicles and control mechanisms

When taken orally in therapeutic doses, drotaverine does not affect the ability to exercise potentially dangerous species activities.

After parenteral (especially intravenous) administration of the drug, it is recommended to refrain from driving vehicles and operating mechanisms for 1 hour (after application).

OVERDOSE

To date, no cases of overdose of No-shpa have been reported.

DRUG INTERACTIONS

With the simultaneous use of No-shpa, it can reduce the antiparkinsonian effect of levodopa.

TERMS AND CONDITIONS OF DISCOUNT FROM PHARMACIES

The drug in the form of a solution for intravenous and intramuscular administration is dispensed by prescription.

The drug in the form of tablets is approved for use as an over-the-counter drug.

TERMS AND CONDITIONS OF STORAGE

Tablets in blisters should be stored at a temperature not exceeding 30°C.

Tablets in a polypropylene vial and a solution for intravenous and intramuscular administration should be stored in a place protected from light, out of the reach of children, at a temperature of 15° to 25°C. Shelf life - 5 years.