Veroshpiron appointment. Veroshpiron capsules - official* instructions for use

The main purpose of veroshpiron is to remove fluid from tissues, that is, diuretic effect. However, unlike other similar drugs, the drug does not remove potassium from the body along with sodium and chlorine, but, on the contrary, promotes its accumulation.

Taking Veroshpiron can provoke the following side effects: headache, dizziness, drowsiness, nausea, abdominal pain, stool upset and endocrine disorders.

In men taking the drug in rare cases gynecomastia (enlargement of the mammary gland), decreased potency and erection are observed, in women - amenorrhea (lack of menstruation) and dysmenorrhea ( painful menstruation), deepening of voice, chest pain, uterine bleeding during menopause. Such changes are temporary and disappear after stopping the use of Veroshpiron.

Veroshpiron can cause allergic reactions body: urticaria, rash, itching, as well as disrupt the function of the kidneys and liver. In case of long-term use, changes in laboratory parameters are possible.

Veroshpiron does not combine well with some drugs, so its use can only be started after medical consultation.

Veroshpiron reduces the effectiveness of anticoagulants, indirect anticoagulants and toxicity of cardiac glycosides.

When prescribing Veroshpiron, you should inform your doctor about taking other medicines, because this drug is able to interact with many of them.

Veroshpiron:

reduces the effectiveness of anticoagulants (coumarin derivatives, Heparin, Indandione);
reduces the toxicity of cardiac glycosides (Strophanthin K, Digitoxin, Celanide, Korglikon, etc.);
reduces vascular sensitivity to Norepinephrine;
reduces the effectiveness of Mitotane;
enhances the effectiveness of antihypertensive and diuretic drugs;
enhances the metabolism of Phenazol;
increases the toxicity of lithium-containing drugs;
accelerates the elimination of Carbenoxolone, and their joint reception leads to sodium retention;
enhances the effect of Buserelin, Triptorelin and Gonadorelin;
when taken simultaneously with salicylates, the diuretic effect of the drug decreases;
when taken with potassium-sparing diuretics or potassium-containing drugs, Indomethacin, aldosterone blockers, angiotensin II antagonists and cyclosporines, there is a risk of developing hyperkalemia;
when taken with cholestyramine and ammonium chloride, the risk of developing acidosis increases;
when taken with non-steroidal anti-inflammatory drugs there is a risk of developing hyperkalemia;
when taken with Fludrocortisone, increased secretion of potassium in the renal tubules develops;

combined use with Digoxin can lead to a slower elimination of the latter and cause its toxic effect on the body.

Potassium-sparing diuretic.

Veroshpiron can provoke the appearance of such side effects from the outside various systems body, like:

Hematopoiesis: thrombocytopenia, agranulocytosis, megaloblastosis.
Central nervous system: ataxia, headaches, drowsiness and lethargy, impaired concentration, in severe cases, lethargy.
Gastrointestinal tract: exacerbation of gastritis, constipation or diarrhea, internal intestinal bleeding, intestinal colic.
Metabolism: increased concentration of urea, hyperchloremic acidosis, alkalosis, hyperuricemia.
Urinary system: kidney failure acute form.
Muscular system: cramps and spasms calf muscles.
Endocrine system: deepening of the voice in women, enlargement of the mammary glands in men, decrease or loss of potency, decreased erectile function. Women may also experience bleeding during established menopause, or absence of menstruation during reproductive age, breast pain of unknown etiology and hirsutism (male pattern hair growth).

Based on the above list, Veroshpiron has a number of side effects.

GCS and diuretics mutually enhance and accelerate the diuretic and natriuretic effects.
The drug enhances the metabolism of phenazole, triptorelin, buserelin, gonadorelin, and reduces the sensitivity of blood vessels to norepinephrine.
Veroshpiron reduces the effectiveness of anticoagulants, indirect anticoagulants and the toxicity of cardiac glycosides.
When taking Veroshpiron with potassium supplements, potassium supplements and potassium-sparing diuretics, ACE inhibitors(acidosis), angiotensin II antagonists, aldosterone blockers, indomethacin, cyclosporine increases the risk of developing hyperkalemia.
Veroshpiron enhances toxic effect lithium due to a decrease in its clearance, accelerates the metabolism and excretion of carbenoxolone, the latter in turn contributes to sodium retention.

Release form and composition

Veroshpiron is available in the form of tablets and capsules.

Pills white and have a flat shape with a bevel on one side and an engraving “VEROSPIRON” and a bevel on the other side. Each cardboard package of the drug contains 1 blister containing 20 tablets

The capsules are hard, opaque, yellow-white in color. The cardboard package contains 3 blisters, each of which contains 10 capsules.

Veroshpiron

is potassium-sparing

diuretic

And it has a pronounced and long-lasting diuretic effect. The active ingredient of this medicinal product is

spironolactone

(one of

hormones

Verospiron is produced in Hungary by GEDEON RICHTER in the following dosage forms:

White (or almost white) tablets with a bevel, flat, round, on one side there is the marking “VEROSPIRON” - 25 mg each, 20 pieces in one blister, in a cardboard package.
Capsules with cap yellow and white body, hard, gelatinous, with a granular fine-grained mixture of white color - 50 mg each, 10 pieces in a blister, 3 blisters in a cardboard package.
Capsules with an orange cap and a yellow body, gelatin, hard, with a granular fine-grained mixture of white color - 100 mg each, 10 pieces in a blister, 3 blisters in a cardboard package.

The drug is available in the form of capsules and tablets. The active element of the drug Veroshpiron, which helps with high blood pressure, is spironolactone. The active ingredient is contained in an amount of 25 mg for tablets, 50 or 100 mg for capsules.

Additional substances in the tablets are talc, silicon dioxide, lactose monohydrate, magnesium stearate, corn starch. Capsules consist of sodium lauryl sulfate, lactose monohydrate, magnesium stearate, corn starch. The cap and body of the capsule also contain gelatin, dyes and titanium dioxide.

Conditions for dispensing from pharmacies

Dispensed by prescription.

The drug should be stored out of the reach of children at a temperature not exceeding 30°C. The shelf life is 5 years.

Veroshpiron price for 1 package from 74 rubles.

Dispensed with a doctor's prescription.

The shelf life of Veroshpiron tablets and capsules is 5 years. The drug must be stored in a dry, dark place, out of reach of children, at an air temperature not exceeding 30° C.

Contraindications

This drug is contraindicated for:

pregnancy and breastfeeding
severe renal failure
Addison's disease
hyperkalemia and hyponatremia
childhood (up to 3 years)
individual intolerance components

It is allowed to use veroshpiron with caution when:

excess calcium in the body
diabetes mellitus
planning surgical interventions
violations menstrual cycle
old age
liver diseases

Indications for Veroshpiron include most conditions and diseases that are accompanied by fluid retention in the body. The drug is prescribed as primary or combination therapy to eliminate edema in chronic heart failure, edema in liver cirrhosis and nephrotic syndrome, as well as other edema syndrome of various origins(origin).

Veroshpiron is indicated for primary hypertension. In combination with other drugs, it successfully treats high blood pressure.

In professional circles and among patients, reviews of the drug are positive character. Contraindications for women: hypersensitivity, renal failure and diabetic nephropathy. Compatibility with alcohol is negative.

According to the instructions, Veroshpiron is prescribed for:

Conditions accompanied by secondary hyperaldosteronism, including nephrotic syndrome, liver cirrhosis and other conditions accompanied by edema;
Edema syndrome against the background chronic heart failure(as the main drug or in combination with other drugs);
Primary hyperaldosteronism (Crohn's syndrome) – for a short time in preoperative period;
Essential hypertension (in combination with other drugs);
Hypokalemia or hypomagnesemia (for the purpose of prevention during treatment with diuretics).

Veroshpiron is also prescribed to establish a diagnosis of primary hyperaldosteronism.

Contraindications to the use of Veroshpiron are:

Anuria;
Severe renal failure;
Lactose intolerance, lactase enzyme deficiency, glucose-galactose malabsorption;
Pregnancy and breastfeeding period;
Childhood up to three years;
Hypersensitivity to any of the components of the drug;
Hyponatremia;
Hyperkalemia.

Veroshpiron is prescribed with caution to patients with metabolic acidosis, hypercalcemia, diabetes mellitus, diabetic nephropathy, liver failure, cirrhosis of the liver, as well as elderly people, women with irregular menstrual cycles, enlarged mammary glands and local or general anesthesia.

Price in pharmacies

The price of Veroshpiron depends on the form of its release, the city and the pharmacy selling the drug. Before purchasing it, it is recommended to check its cost in several pharmacies.

tablets 25 mg, 20 pieces – 72-87 rubles, 56-68 hryvnia;
capsules 50 mg, 30 pieces – 160-199 rubles, 89-116 hryvnia;
capsules 100 mg, 30 pieces – 232-263 rubles, 107-178 hryvnia.

Veroshpiron is available in pharmacies with a doctor's prescription.

How much does Veroshpiron cost? Average price in pharmacies it is at the level of 220 rubles.

Overdose

For essential hypertension, the daily dose for adults is 50-100 mg once and can be increased to 200 mg. The dosage is increased gradually - once every 2 weeks. The minimum duration of treatment is 2 weeks.

For idiopathic hyperaldosteronism, the dosage of the drug is 100-400 mg/day.

For severe hyperaldosteronism and hypokalemia, the daily dose is 300 mg (maximum 400 mg) in 2-3 doses. After the condition improves, the dose is gradually reduced to 25 mg/day.

For hypokalemia and/or hypomagnesemia, Veroshpiron is prescribed at a dose of 25-100 mg/day, once or in several doses. The maximum daily dose should not exceed 400 mg.

When diagnosing and treating primary hyperaldosteronism, Veroshpiron is prescribed as a diagnostic agent for a short diagnostic test at 400 mg/day for 4 days. Daily dosage distributed evenly into several doses throughout the day.

If the concentration of potassium in the blood increases while taking the drug and decreases after its discontinuation, the presence of primary hyperaldosteronism can be assumed.

For a long-term diagnostic test, the drug is prescribed at a dosage of 400 mg/day (3-4 times a day) for 3-4 weeks. When correction of hypokalemia is achieved and arterial hypertension the presence of primary hyperaldosteronism can be assumed.

After confirming the diagnosis of hyperaldosteronism, as a short course of preoperative therapy, Veroshpiron is prescribed in a dosage of 100-400 mg, dividing it into 1-4 doses during the entire period of preparation for surgical operation.

If surgery is not indicated, then Veroshpiron is used for long-term maintenance therapy, using the lowest effective dose, which is selected individually for each patient.

When treating edema due to nephrotic syndrome, the daily dose for adults is usually 100-200 mg.

In case of edema syndrome against the background of chronic heart failure, the drug is prescribed daily for 5 days, 100-200 mg/day in 2-3 doses, in combination with a loop or thiazide diuretic. In some cases, the daily dose is reduced to 25 mg. The maintenance dose is selected individually. The maximum daily dose is 200 mg.

For edema due to liver cirrhosis, the daily dose of Veroshpiron for adults is usually 100 mg if the ratio of sodium and potassium ions (Na / K) in the urine exceeds 1.0. If the ratio is less than 1.0, then the daily dose is usually 200-400 mg. The maintenance dose is selected individually.

For edema in children, the initial dose is 1-3.3 mg/kg body weight or 30-90 mg/m2/day in 1-4 doses. After 5 days, the dose is adjusted. If necessary, it is increased 3 times.

Symptoms of overdose: nausea, vomiting, dizziness, decreased blood pressure, diarrhea, skin rash, hyperkalemia (paresthesia, muscle weakness, arrhythmias), hyponatremia (dry mouth, thirst, drowsiness), hypercalcemia, dehydration, increased urea concentration.

The treatment is gastric lavage, symptomatic treatment dehydration and arterial hypotension.

In case of hyperkalemia, it is important to normalize water-electrolyte metabolism with the help of potassium-sparing diuretics, rapid parenteral administration dextrose solution (5-20% solutions) with insulin at the rate of 0.25-0.5 IU per 1 g of dextrose. In severe cases, hemodialysis is performed.

Indications for use

Edema syndrome due to heart failure (alone or in combination with other drugs and diuretics);
essential hypertension (as part of complex therapy);
for the prevention of hypokalemia while taking other diuretics;
Conn's syndrome (primary hyperaldosteronism);
conditions of secondary hyperaldosteronism (ascites and edema in liver cirrhosis, nephrotic syndrome, etc.);
to perform diagnostic tests for hyperaldosteronism.

Contraindications

Children under 3 years of age;
pregnancy period;
breastfeeding period;
anuria (impaired urine excretion up to its complete absence);
lactose intolerance or lactase deficiency;
galactose and glucose malabsorption syndrome;
Addison's disease;
severe forms renal failure;
hyponatremia;
hyperkalemia;
hypersensitivity to one of the components of the drug.

Veroshpiron is prescribed with caution when:

Side effects

From the outside nervous system – lethargy, headaches and dizziness, ataxia, drowsiness, confusion, lethargy.
From the outside digestive organs – nausea, diarrhea, constipation, colic and abdominal pain, vomiting, gastritis, intestinal or stomach bleeding, liver dysfunction.
From the blood side – thrombocytopenia, megablastosis, agranulocytosis.
From the outside endocrine organs – in women, menstrual irregularities (dysmenorrhea, metrorrhagia during menopause, amenorrhea), pain in the mammary glands, hirsutism, breast cancer, in men - gynecomastia.
From the outside immune system – allergic reactions in the form of drug fever, itching, urticaria, erythematous and papular rash.
From the kidneys– acute renal failure.
From the outside muscular system – muscle spasms, cramps of the calf muscles.
From the skin and hair– hypertrichosis (excessive hair growth), baldness.
Metabolic disorders– increased blood levels of urea, creatinine and uric acid, decreased sodium levels in the blood, hyperchloremic alkalosis or acidosis.

In most cases, after discontinuation of Veroshpiron, side effects gradually disappear.

Treatment with Veroshpiron

How to take Veroshpiron?

Tablets or capsules are swallowed whole without chewing. It is advisable to take the drug in the morning or during the day, as taking it before bedtime will disrupt your usual routine.

It is recommended to take Veroshpiron simultaneously with meals or immediately after them. If you miss a dosage, if no more than 4 hours have passed since the prescribed time, you must immediately take the missed dose of the drug. In other cases, you should take the medicine in the usual dosage during your next appointment.

An overdose of Veroshpiron is manifested by the following symptoms:

nausea and vomiting;
diarrhea;
skin rash;
confusion;
drowsiness;
dehydration of the body.

If the above is identified

symptoms

the patient must rinse the stomach (call

) and consult a doctor. There is no specific antidote for Veroshpiron. To help the patient, symptomatic therapy is carried out.

When a diagnosis of hyperaldosteronism is made, the drug is recommended in a dosage of 100 to 400 mg per day, one to four times a day. In other cases, the medicine is taken orally at 0.05 - 0.3 grams per day.

The dose is usually divided into two to four doses. If the patient's condition has improved, the dose is reduced to 0.025 g per day.

People suffering from Parkinson's syndrome are prescribed twenty-day courses with breaks of five months. For hypertension, the medicine is prescribed at 0.025 g.

four times a day.

Teenagers can obtain and take medication in any form only with a prescription.

For edema dosage

The instructions for use indicate that the dosage of Veroshpiron depends on the disease:

For idiopathic hyperaldosteronism, the drug is prescribed at a dose of 100-400 mg/day.
For essential hypertension, the daily dose for adults is usually 50-100 mg once and can be increased to 200 mg, and the dose should be increased gradually, once every 2 weeks. To achieve an adequate response to therapy, the drug must be taken for at least 2 weeks. If necessary, adjust the dose.
For hypokalemia and/or hypomagnesemia caused by diuretic therapy, Veroshpiron is prescribed at a dose of 25-100 mg/day, once or in several doses. The maximum daily dose is 400 mg if oral potassium supplements or other methods of replenishing potassium deficiency are ineffective.
For severe hyperaldosteronism and hypokalemia, the daily dose is 300 mg (maximum 400 mg) in 2-3 doses; as the condition improves, the dose is gradually reduced to 25 mg/day.
When diagnosing and treating primary hyperaldosteronism, Veroshpiron is prescribed as a diagnostic tool for a short diagnostic test for 4 days at 400 mg/day, dividing the daily dose into several doses per day. If the concentration of potassium in the blood increases while taking the drug and decreases after its discontinuation, the presence of primary hyperaldosteronism can be assumed. For a long-term diagnostic test, the drug is prescribed at the same dose for 3-4 weeks. When correction of hypokalemia and arterial hypertension is achieved, the presence of primary hyperaldosteronism can be assumed.
Once the diagnosis of hyperaldosteronism has been established using more accurate diagnostic methods, as a short course of preoperative therapy for primary hyperaldosteronism, Veroshpiron should be taken in daily dose 100-400 mg, divided into 1-4 doses during the entire period of preparation for surgery. If surgery is not indicated, then Veroshpiron is used for long-term maintenance therapy, using the lowest effective dose, which is selected individually for each patient.
In case of edema syndrome against the background of chronic heart failure, the drug is prescribed daily for 5 days, 100-200 mg/day in 2-3 doses, in combination with a loop or thiazide diuretic. Depending on the effect, the daily dose is reduced to 25 mg. The maintenance dose is selected individually. The maximum daily dose is 200 mg.
For edema due to liver cirrhosis, the daily dose of Veroshpiron for adults is usually 100 mg if the ratio of sodium and potassium ions (Na / K) in the urine exceeds 1.0. If the ratio is less than 1.0, then the daily dose is usually 200-400 mg. The maintenance dose is selected individually.
When treating edema due to nephrotic syndrome, the daily dose for adults is usually 100-200 mg. There was no effect of spironolactone on the main pathological process, and therefore application this drug recommended only in cases where other types of therapy are ineffective.

For edema in children, the initial dose is 1-3.3 mg/kg body weight or 30-90 mg/m2/day in 1-4 doses. After 5 days, the dose is adjusted and, if necessary, increased by 3 times compared to the original.

Overdose is expressed in the following symptoms:

confusion of thoughts;
drowsy state;
nausea and vomiting;
diarrhea;
skin rash;
dehydration.

In case of observation specified symptoms You should perform gastric lavage (induce vomiting) and visit a doctor. Providing assistance is limited to symptomatic therapy.

Analogs

Analogs by ATC code: Aldactone, Veroshpilaktone, Spirix, Spironol, Uractone.

Do not decide to change the drug on your own; consult your doctor.

Analogues (synonyms) of Veroshpiron, which include the same active ingredient spironolactone are:

Aldactone (UK);
Vero-Spironolactone (Russia);
Veroshpilakton (Russia);
Spirix (Denmark);
Spironaxane (UK);
Spironol (Russia);
Spironolactone (Russia);
Spironolactone (Unilan) (USA);
Urakton (Italy).

The pharmacological group contains other analogues of the drug. Such agents as furosemide, indapamide, diuver, veroshpilactone, prolactin, triampur and others are widely used. Funds are available in Ukraine, Perm, St. Petersburg, Omsk and other cities of the Russian Federation.

Veroshpiron or Furosemide, which is better?

In this matter, everything depends on the goals pursued by the patient. Furosemide is a cheaper analogue of veroshpiron. It helps remove fluid from the body, but only veroshpiron has a potassium-sparing mechanism. Therefore, questions about choice should be decided individually.

Veroshpiron or Diuver, which is better?

According to cardiologists, the first drug is best taken to prevent heart failure. It is preferable to take Diuver for the direct treatment of this pathology. In any case, before replacing one medicine with another, consult your doctor, as the difference between taking them can be significant.

Veroshpiron has several structural analogues, which contain the same list of components and have a similar effect on the body.

These include:

Vero-Spironolactone;
Spironol;
Verospilactone;
Spirix;
Aldactone

Before using analogues, consult your doctor.

Use during pregnancy and lactation

The drug should not be taken by pregnant and lactating women. But, if indicated, the use of Veroshpiron is allowed in the second and third trimester of pregnancy to eliminate edema during pregnancy, if the expected benefit to the mother is higher than the risk to the fetus.

Taking Veroshpiron is contraindicated for women during

pregnancy lactation

Taking Veroshpiron is contraindicated for women during pregnancy and lactation.

Special instructions

During treatment with Veroshpiron, a temporary increase in serum urea nitrogen levels is possible, especially with reduced renal function and hyperkalemia.

When prescribing Veroshpiron to patients with impaired renal and liver function, and elderly patients, regular monitoring of serum electrolytes and renal function is necessary.

Taking Veroshpiron makes it difficult to detect the concentration of digoxin, cortisol and adrenaline in the blood.

During treatment with Veroshpiron, you should avoid eating foods rich in potassium, and drinking alcohol is contraindicated.

At the beginning of treatment, it is forbidden to drive a car or engage in activities that require increased concentration attention and speed of psychomotor reactions. The duration of restrictions is set individually.

During treatment with spironolactone, alcohol intake is prohibited.
Rapid weight loss should be avoided.
Hyperkalemia in patients with severe heart failure
Spironolactone may increase the risk of hyperkalemia in patients with diabetic nephropathy.
Caution should be exercised when prescribing to patients prone to acidosis or hyperkalemia due to an underlying disease (for example, diabetes mellitus).
Caution should also be exercised in patients with moderate renal impairment (serum creatinine between 1.2 mg/100 ml and 1.8 mg/100 ml or creatinine clearance between 60 ml/min and 30 ml/min), hypotension or hypovolemia.
Included dosage form includes lactose. The drug should not be prescribed to patients with rare congenital forms of lactose intolerance: Lapp lactase deficiency, glucose-galactose malabsorption.
Treatment should be stopped or suspended if blood potassium levels exceed 4 mg/dL.
Spironolactone therapy may interfere with the determination of serum and digoxin, plasma cortisol and epinephrine.
Concomitant intake of potassium supplements, diet, rich in potassium, taking other potassium-sparing diuretics, taking potassium-containing salt substitutes, taking ACE inhibitors, angiotensin II antagonists, aldosterone receptor antagonists, heparin or low molecular weight heparins, trimethoprim or other drugs that cause hyperkalemia may lead to severe hyperkalemia, especially in patients with renal impairment.
Hyperkalemia can be life-threatening. Serum potassium levels should be carefully monitored in patients with severe heart failure. If blood potassium levels exceed 3.5 mmol/L, potassium-sparing diuretics should be avoided. It is recommended to monitor potassium and creatinine levels in the blood one week after starting treatment, and then every six months.
Spironolactone therapy may cause a transient increase in serum urea nitrogen, especially in patients with pre-existing renal impairment and hyperkalemia. Spironolactone may cause the development of reversible hyperchloremic metabolic acidosis. Therefore, in patients with impaired renal and hepatic function, as well as in elderly patients, the biochemical parameters renal function, and electrolyte balance.

Drug interactions

The article describes the use of the drug "Veroshpiron", for which it is not recommended to take it. It also contains information about contraindications and side effects.

Annotation

Many patients are concerned about the question, what is Veroshpiron used for? It turns out that the list of uses for this diuretic potassium-sparing agent is quite wide. The main active ingredient is Spironolactone, and the medicine is produced in the form of capsules and film-coated tablets.

In this article you can find instructions for use medicinal product Veroshpiron. Feedback from site visitors - consumers - is presented of this medicine, as well as the opinions of specialist doctors on the use of Veroshpiron in their practice. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Veroshpiron in the presence of existing structural analogues. Use for the treatment of arterial hypertension and diuretic effect in adults, children, as well as during pregnancy and lactation. Composition of the drug.

Veroshpiron- potassium-sparing diuretic, competitive aldosterone antagonist.

In the distal parts of the nephron, Veroshpiron prevents the retention of sodium and water by aldosterone and suppresses the potassium-removing effect of aldosterone, reduces the synthesis of permeases in the aldosterone-dependent area of the collecting ducts and distal tubules. By binding to aldosterone receptors, it increases the excretion of sodium, chlorine and water ions in the urine, reduces the excretion of potassium and urea ions, and reduces the acidity of urine.

The hypotensive effect is due to the diuretic effect. The diuretic effect appears on days 2-5 of treatment.

Compound

Spironolactone + excipients.

Pharmacokinetics

After oral administration, it is quickly and completely absorbed from the gastrointestinal tract. Bioavailability is about 100%, and food intake increases it to 100%. Spironolactone penetrates poorly into organs and tissues, while spironolactone itself and its metabolites penetrate the placental barrier, and canrenone penetrates into breast milk. During the biotransformation process in the liver, active sulfur-containing metabolites 7-alpha-thiomethylspironolactone and canrenone are formed. It is excreted primarily by the kidneys (50% in the form of metabolites, 10% unchanged) and partially through the intestines.

Indications

essential hypertension (as part of combination therapy);
edema syndrome in chronic heart failure (can be used as monotherapy and in combination with standard therapy);
conditions in which secondary hyperaldosteronism can be detected, incl. liver cirrhosis, accompanied by ascites and/or edema, nephrotic syndrome and other conditions accompanied by edema;
hypokalemia/hypomagnesemia (as aid for its prevention during treatment with diuretics and if it is impossible to use other methods of correcting potassium levels);
primary hyperaldosteronism (Conn's syndrome) - for a short preoperative course of treatment;
to establish the diagnosis of primary hyperaldosteronism.

Release forms

Tablets 25 mg.

Capsules 50 mg and 100 mg.

Instructions for use and dosage

For essential hypertension, the daily dose for adults is usually 50-100 mg once and can be increased to 200 mg, and the dose should be increased gradually, once every 2 weeks. To achieve an adequate response to therapy, the drug must be taken for at least 2 weeks. If necessary, adjust the dose.

For idiopathic hyperaldosteronism, the drug is prescribed at a dose of 100-400 mg per day.

For severe hyperaldosteronism and hypokalemia, the daily dose is 300 mg (maximum 400 mg) in 2-3 doses; as the condition improves, the dose is gradually reduced to 25 mg per day.

For hypokalemia and/or hypomagnesemia caused by diuretic therapy, Veroshpiron is prescribed at a dose of 25-100 mg per day, once or in several doses. The maximum daily dose is 400 mg if oral potassium supplements or other methods of replenishing potassium deficiency are ineffective.

When diagnosing and treating primary hyperaldosteronism, Veroshpiron is prescribed as a diagnostic tool for a short diagnostic test for 4 days, 400 mg per day, dividing the daily dose into several doses per day. If the concentration of potassium in the blood increases while taking the drug and decreases after its discontinuation, the presence of primary hyperaldosteronism can be assumed. For a long-term diagnostic test, the drug is prescribed at the same dose for 3-4 weeks. When correction of hypokalemia and arterial hypertension is achieved, the presence of primary hyperaldosteronism can be assumed.

After the diagnosis of hyperaldosteronism is established using more accurate diagnostic methods, as a short course of preoperative therapy for primary hyperaldosteronism, Veroshpiron should be taken in a daily dose of 100-400 mg, divided into 1-4 doses during the entire period of preparation for surgery. If surgery is not indicated, then Veroshpiron is used for long-term maintenance therapy, using the lowest effective dose, which is selected individually for each patient.

When treating edema due to nephrotic syndrome, the daily dose for adults is usually 100-200 mg. No effect of spironolactone on the underlying pathological process has been identified and therefore the use of this drug is recommended only in cases where other types of therapy are ineffective.

In case of edema syndrome against the background of chronic heart failure, the drug is prescribed daily for 5 days, 100-200 mg per day in 2-3 doses, in combination with a loop or thiazide diuretic. Depending on the effect, the daily dose is reduced to 25 mg. The maintenance dose is selected individually. The maximum daily dose is 200 mg.

For edema due to liver cirrhosis, the daily dose of Veroshpiron for adults is usually 100 mg if the ratio of sodium and potassium ions (Na+/K+) in the urine exceeds 1.0. If the ratio is less than 1.0, then the daily dose is usually 200-400 mg. The maintenance dose is selected individually.

For edema in children, the initial dose is 1-3.3 mg/kg body weight or 30-90 mg/m2 per day in 1-4 doses. After 5 days, the dose is adjusted and, if necessary, increased by 3 times compared to the original.

Side effect

nausea, vomiting;
diarrhea;
ulcerations and bleeding from the gastrointestinal tract;
gastritis;
intestinal colic;
abdominal pain;
constipation;
ataxia;
lethargy;
dizziness;
headache;
drowsiness;
confusion;
agranulocytosis, thrombocytopenia, megaloblastosis;
hyperuricemia, hypercreatininemia, increased urea concentration, hyperkalemia, hyponatremia;
deepening of the voice;
in men - gynecomastia (the likelihood of development depends on the dose, duration of treatment and is usually reversible and disappears after discontinuation of Veroshpiron, only in rare cases breast remains slightly enlarged);
decreased potency and erection;
in women - menstrual irregularities;
dysmenorrhea;
amenorrhea;
metrorrhagia in menopause;
hirsutism;
pain in the mammary glands;
hives;
drug fever;
alopecia;
acute renal failure;
muscle spasm;
cramps of the calf muscles.

Contraindications

Addison's disease;
hyperkalemia;
hyponatremia;
severe renal failure (creatinine clearance less than 10 ml/min);
anuria;
lactose intolerance, lactase deficiency, glucose/galactose malabsorption syndrome;
pregnancy;
lactation period ( breast-feeding);
children under 3 years of age;
hypersensitivity to the components of the drug.

Use during pregnancy and breastfeeding

The use of Veroshpiron is contraindicated during pregnancy and lactation.

Special instructions

When using Veroshpiron, a temporary increase in the level of urea nitrogen in the blood serum is possible, especially with reduced renal function and hyperkalemia. It is also possible to develop reversible hyperchloremic metabolic acidosis.

When prescribing Veroshpiron to patients with impaired renal and liver function, and elderly patients, regular monitoring of serum electrolytes and renal function is necessary.

It is believed among ordinary people that Veroshpiron is capable of reducing weight, but the weight loss caused by the drug can only be correlated with the number of kilograms lost in liquid excess weight and nothing more. It has nothing to do with diets or real weight loss.

Taking Veroshpiron makes it difficult to determine the concentration of digoxin, cortisol and adrenaline in the blood.

Despite the lack of direct impact on carbohydrate metabolism, availability diabetes mellitus, especially with diabetic nephropathy, requires special caution when prescribing Veroshpiron due to the possibility of developing hyperkalemia.

When treated with non-steroidal anti-inflammatory drugs while taking Veroshpiron, kidney function and blood electrolyte levels should be monitored.

During treatment with Veroshpiron, alcohol consumption is contraindicated, and food rich in potassium should be avoided.

During treatment, alcohol consumption is contraindicated.

Impact on the ability to drive vehicles and operate machinery

During the initial period of treatment, it is prohibited to drive a car or engage in activities that require increased concentration and speed of psychomotor reactions. The duration of restrictions is set individually.

Drug interactions

Veroshpiron reduces the effect of anticoagulants, indirect anticoagulants (heparin, coumarin derivatives, indanedione) and the toxicity of cardiac glycosides (since normalizing the level of potassium in the blood prevents the development of toxicity).

Enhances the metabolism of phenazole.

Reduces the sensitivity of blood vessels to norepinephrine (requires caution during anesthesia).

Increases T1/2 of digoxin, so digoxin intoxication is possible.

Strengthens the toxic effect of lithium due to a decrease in its clearance.

Accelerates the metabolism and excretion of carbenoxolone.

Carbenoxolone promotes sodium retention by spironolactone.

Glucocorticosteroids (GCS) and diuretics (benzothiazine derivatives, furosemide, ethacrynic acid) enhance and accelerate the diuretic and natriuretic effects.

Enhances the effect of diuretic and antihypertensive drugs.

GCS enhance the diuretic and natriuric effect in hypoalbuminemia and/or hyponatremia.

The risk of developing hyperkalemia increases when taking Veroshpiron with potassium preparations, potassium supplements and potassium-sparing diuretics, ACE inhibitors (acidosis), angiotensin 2 antagonists, aldosterone blockers, indomethacin, cyclosporine.

Salicylates and indomethacin reduce the diuretic effect.

Ammonium chloride and cholestyramine contribute to the development of hyperkalemic metabolic acidosis.

Fludrocortisone causes a paradoxical increase in tubular secretion of potassium.

Reduces the effect of mitotane.

Enhances the effect of triptorelin, buserelin, gonadorelin.

Analogues of the drug Veroshpiron

Structural analogues according to active substance:

Aldactone;
Vero-Spironolactone;
Verospilactone;
Spirix;
Spironaxane;
Spironol;
Spironolactone;
Spironolactone (Unilan);
Urakton.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.

Veroshpiron (INN - spironolactone) is a potassium-sparing diuretic used for primary arterial hypertension, chronic heart failure and closely related primary and secondary hyperaldosteronism (excessive production of aldosterone by the adrenal cortex). Acting as a competitive antagonist (“antipode”, if you like) of aldosterone, veroshpirone and other potassium-sparing diuretics in lately are considered as a separate specific group cardiovascular drugs, grouped under the name “aldosterone receptor blockers”.

In the person of aldosterone, one can easily consider the most powerful mineralcorticoid hormone in terms of the degree of its influence on the body, which is formed in the adrenal cortex. Its main function is to control the levels of sodium and potassium ions in order to maintain constant homeostasis. This is achieved through two mechanisms: stimulating the reabsorption of sodium ions in the distal convoluted tubules of the kidneys and “pushing” potassium ions from the blood into the filtrate. Normally, this process is in balance, but if chronic heart failure develops against the background of excess aldosterone, then the reabsorption of sodium, and, consequently, water, increases. This circumstance causes the appearance of edema and an increase in the volume of circulating blood. A deficiency of potassium and magnesium ions provokes disorders heart rate. Then the vicious circle closes and secondary hyperaldosteronism develops, when, due to chronic heart failure, the formation of adrenocorticotropic hormone by the pituitary gland is activated, which, in turn, stimulates the release of aldosterone, which is already a lot due to the excessive activity of the renin-angiotensin-aldosterone system.

And here veroshpiron appears in the foreground, which, rolling up its sleeves, immediately and for a long time (since the drug has a prolonged effect) begins to create confusion in the aldosterone “Barbarossa plan”: it inhibits the retention of sodium and water ions by aldosterone in the distal parts of the renal tubules, prevents removal of potassium from the body. By interacting with aldosterone receptors, veroshpiron increases the excretion of sodium chloride ions and water in the urine, while simultaneously reducing the acidity of urine. Veroshpiron is not a diuretic in the full sense of the word: its diuretic effect is inconsistent and makes itself felt only on days 2-5 of pharmacotherapy.

The drug is available in the form of tablets and capsules. The dosage regimen is determined by the doctor. During treatment for any alcoholic products a strict taboo is imposed. In case of existing liver and kidney diseases, in elderly patients, as well as in concomitant use of non-steroidal anti-inflammatory drugs, it is recommended to regularly “monitor” the content of electrolytes in the blood and the functioning of the kidneys.

Pharmacology

Potassium-sparing diuretic, long-acting competitive aldosterone antagonist (mineralocorticoid hormone of the adrenal cortex).

In the distal parts of the nephron, spironolactone prevents the retention of sodium and water by aldosterone and suppresses the potassium-removing effect of aldosterone, reduces the synthesis of permeases in the aldosterone-dependent area of the collecting ducts and distal tubules. By binding to aldosterone receptors, it increases the excretion of sodium, chlorine and water ions in the urine, reduces the excretion of potassium and urea ions, and reduces the acidity of urine.

The hypotensive effect is due to the diuretic effect. The diuretic effect appears on days 2-5 of treatment.

Pharmacokinetics

Suction

After oral administration, it is quickly and completely absorbed from the gastrointestinal tract. Bioavailability is about 100%, and food intake increases it to 100%. After a daily dose of 100 mg of spironolactone for 15 days, Cmax is 80 ng/ml, the time to reach Cmax after the next morning appointment- 2-6 hours

Distribution

Plasma protein binding is 98%.

Spironolactone penetrates poorly into organs and tissues, while spironolactone itself and its metabolites penetrate the placental barrier, and canrenone penetrates into breast milk. Vd - 0.05 l/kg.

Metabolism

During the biotransformation process in the liver, active sulfur-containing metabolites 7-alpha-thiomethylspironolactone and canrenone are formed. Canrenone reaches its Cmax after 2-4 hours, its binding to plasma proteins is 90%.

Removal

T1/2 - 13-24 hours. Excreted mainly by the kidneys (50% in the form of metabolites, 10% unchanged) and partially through the intestines. Canrenone excretion (mainly by the kidneys) is two-phase, T1/2 in the first phase is 2-3 hours, in the second - 12-96 hours.

Pharmacokinetics in special clinical situations

With cirrhosis of the liver and heart failure, the duration of T1/2 increases without signs of cumulation, the likelihood of which is higher in chronic renal failure and hyperkalemia.

Release form

Hard gelatin capsules, size No. 3, with an opaque yellow cap and an opaque white body; the contents of the capsules are a fine-grained granular powder mixture of white color.

Excipients: sodium lauryl sulfate - 2.5 mg, magnesium stearate - 2.5 mg, corn starch - 42.5 mg, lactose monohydrate - 127.5 mg.

Composition of hard gelatin capsule: cap - quinoline yellow dye (E104) - 0.48%, titanium dioxide (E171) - 2%, gelatin - up to 100%; body - titanium dioxide (E171) - 2%, gelatin - up to 100%.

10 pcs. - blisters (3) - cardboard packs.

Dosage

For idiopathic hyperaldosteronism, the drug is prescribed at a dose of 100-400 mg/day.

For severe hyperaldosteronism and hypokalemia, the daily dose is 300 mg (maximum 400 mg) in 2-3 doses; as the condition improves, the dose is gradually reduced to 25 mg/day.

For hypokalemia and/or hypomagnesemia caused by diuretic therapy, Veroshpiron is prescribed at a dose of 25-100 mg/day, once or in several doses. The maximum daily dose is 400 mg if oral potassium supplements or other methods of replenishing potassium deficiency are ineffective.

When diagnosing and treating primary hyperaldosteronism, Veroshpiron is prescribed as a diagnostic tool for a short diagnostic test for 4 days at 400 mg/day, dividing the daily dose into several doses per day. If the concentration of potassium in the blood increases while taking the drug and decreases after its discontinuation, the presence of primary hyperaldosteronism can be assumed. For a long-term diagnostic test, the drug is prescribed at the same dose for 3-4 weeks. When correction of hypokalemia and arterial hypertension is achieved, the presence of primary hyperaldosteronism can be assumed.

When treating edema due to nephrotic syndrome, the daily dose for adults is usually 100-200 mg. No effect of spironolactone on the underlying pathological process has been identified, and therefore the use of this drug is recommended only in cases where other types of therapy are ineffective.

In case of edema syndrome against the background of chronic heart failure, the drug is prescribed daily for 5 days, 100-200 mg/day in 2-3 doses, in combination with a loop or thiazide diuretic. Depending on the effect, the daily dose is reduced to 25 mg. The maintenance dose is selected individually. The maximum daily dose is 200 mg.

For edema due to liver cirrhosis, the daily dose of Veroshpiron for adults is usually 100 mg if the ratio of sodium and potassium ions (Na + /K +) in the urine exceeds 1.0. If the ratio is less than 1.0, then the daily dose is usually 200-400 mg. The maintenance dose is selected individually.

Overdose

Symptoms: nausea, vomiting, dizziness, decreased blood pressure, diarrhea, skin rash, hyperkalemia (paresthesia, muscle weakness, arrhythmias), hyponatremia (dry mouth, thirst, drowsiness), hypercalcemia, dehydration, increased urea concentration.

Treatment: gastric lavage, symptomatic treatment of dehydration and arterial hypotension. In case of hyperkalemia, it is necessary to normalize water-electrolyte metabolism with the help of potassium-removing diuretics, rapid parenteral administration of a dextrose solution (5-20% solutions) with insulin at the rate of 0.25-0.5 units per 1 g of dextrose; if necessary it is possible reintroduction dextrose. In severe cases, hemodialysis is performed.

Interaction

Enhances the metabolism of phenazole.

Reduces the sensitivity of blood vessels to norepinephrine (requires caution during anesthesia).

Increases T1/2 of digoxin, so digoxin intoxication is possible.

Strengthens the toxic effect of lithium due to a decrease in its clearance.

Accelerates the metabolism and excretion of carbenoxolone.

Carbenoxolone promotes sodium retention by spironolactone.

GCS and diuretics (benzothiazine derivatives, furosemide, ethacrynic acid) enhance and accelerate the diuretic and natriuretic effects.

Enhances the effect of diuretic and antihypertensive drugs.

GCS enhance the diuretic and natriuric effect in hypoalbuminemia and/or hyponatremia.

The risk of developing hyperkalemia increases when taking Veroshpiron with potassium supplements, potassium supplements and potassium-sparing diuretics, ACE inhibitors (acidosis), angiotensin II antagonists, aldosterone blockers, indomethacin, cyclosporine.

Salicylates and indomethacin reduce the diuretic effect.

Ammonium chloride and cholestyramine contribute to the development of hyperkalemic metabolic acidosis.

Fludrocortisone causes a paradoxical increase in tubular secretion of potassium.

Reduces the effect of mitotane.

Enhances the effect of triptorelin, buserelin, gonadorelin.

Side effects

From the outside digestive system: nausea, vomiting, diarrhea, ulceration and bleeding from the gastrointestinal tract, gastritis, intestinal colic, abdominal pain, constipation, impaired liver function.

From the central nervous system and peripheral nervous system: ataxia, lethargy, dizziness, headache, drowsiness, lethargy, confusion.

From the hematopoietic system: agranulocytosis, thrombocytopenia, megaloblastosis.

Metabolic: hyperuricemia, hypercreatininemia, increased urea concentration, hyperkalemia, hyponatremia, metabolic hyperchloremic acidosis or alkalosis.

From the outside endocrine system: deepening of the voice, in men - gynecomastia (the likelihood of development depends on the dose, duration of treatment and is usually reversible and disappears after discontinuation of Veroshpiron, only in rare cases the mammary gland remains slightly enlarged), decreased potency and erection; in women - menstrual irregularities, dysmenorrhea, amenorrhea, metrorrhagia during menopause, hirsutism, pain in the mammary glands, breast carcinoma (no connection with taking the drug has been established).

Allergic reactions: urticaria; rarely - maculopapular and erythematous rash, drug fever, itching.

Dermatological reactions: alopecia, hypertrichosis.

From the urinary system: acute renal failure.

From the outside musculoskeletal system: muscle spasms, cramps of the calf muscles.

Indications

essential hypertension (as part of combination therapy);
edema syndrome in chronic heart failure (can be used as monotherapy and in combination with standard therapy);
conditions in which secondary hyperaldosteronism can be detected, incl. liver cirrhosis, accompanied by ascites and/or edema, nephrotic syndrome and other conditions accompanied by edema;
hypokalemia/hypomagnesemia (as an adjuvant for its prevention during treatment with diuretics and when it is impossible to use other methods of correcting potassium levels);
primary hyperaldosteronism (Conn's syndrome) - for a short preoperative course of treatment;
to establish the diagnosis of primary hyperaldosteronism.

Contraindications

Addison's disease;
hyperkalemia;
hyponatremia;
severe renal failure (creatinine clearance less than 10 ml/min);
anuria;
lactose intolerance, lactase deficiency, glucose/galactose malabsorption syndrome;
pregnancy;
lactation period (breastfeeding);
children under 3 years of age;
hypersensitivity to the components of the drug.

The drug should be prescribed with caution in case of hypercalcemia, metabolic acidosis, AV block (hyperkalemia contributes to its intensification), diabetes mellitus (with confirmed or suspected chronic renal failure), diabetic nephropathy, surgical interventions, taking medications that cause gynecomastia, local and general anesthesia, menstrual irregularities, breast enlargement, liver failure, liver cirrhosis, as well as elderly patients.

Features of application

Use during pregnancy and breastfeeding

The use of Veroshpiron is contraindicated during pregnancy and lactation.

If it is necessary to use the drug during lactation, breastfeeding should be discontinued.

Use for liver dysfunction

The drug should be prescribed with caution in case of liver failure or liver cirrhosis.

When prescribing Veroshpiron to patients with liver disorders, regular monitoring of serum electrolytes and renal function is necessary.

Use for renal impairment

The drug is contraindicated in severe renal failure (creatinine clearance less than 10 ml/min). The drug should be prescribed with caution for diabetic nephropathy.

When prescribing Veroshpiron to patients with impaired renal function, regular monitoring of serum electrolytes and renal function is necessary.

Special instructions

When prescribing Veroshpiron to patients with impaired renal and liver function, and elderly patients, regular monitoring of serum electrolytes and renal function is necessary.

Taking Veroshpiron makes it difficult to determine the concentration of digoxin, cortisol and adrenaline in the blood.

Despite the absence of a direct effect on carbohydrate metabolism, the presence of diabetes mellitus, especially with diabetic nephropathy, requires special caution when prescribing Veroshpiron due to the possibility of developing hyperkalemia.

When treating NSAIDs while taking Veroshpiron, kidney function and blood electrolyte levels should be monitored.

During treatment with Veroshpiron, you should avoid eating foods rich in potassium.

During treatment, alcohol consumption is contraindicated.

Impact on the ability to drive vehicles and operate machinery

Pharmacological action

A potassium-sparing diuretic, it is a competitive aldosterone antagonist. In the distal parts of the renal tubules, the drug inhibits the action of aldosterone, aimed at retaining sodium and water in the body, as well as increasing potassium secretion. Due to the blockade of aldosterone receptors, the urinary excretion of sodium and chlorine ions increases, and the excretion of potassium and hydrogen ions decreases.

The hypotensive effect of the drug is due to the presence of a diuretic effect.

The diuretic effect develops on days 2-5 of treatment and persists for 2-3 days after discontinuation of the drug.

Pharmacokinetics

Suction

When taken orally, it is absorbed from the gastrointestinal tract. Bioavailability is 90%.

Eating increases the absorption and bioavailability of spironolactone.

Distribution

Plasma protein binding - 90%. Spironolactone and its metabolites cross the placenta and are excreted in breast milk.

Metabolism

Rapidly metabolized in the liver. The main metabolites of spironolactone are canrenone and 7-alpha-(thiomethyl)-spironolactone.

Removal

Spironolactone and its metabolites are excreted mainly in the urine and, to a lesser extent, in the feces.

Indications for use of the drug VEROSHPIRON

Primary hyperaldosteronism (to clarify the diagnosis and short-term preoperative treatment, as well as for long-term treatment if surgery is impossible);

Edema syndrome (advisable joint use with other diuretics) for chronic heart failure (in the absence of effect or intolerance to other types of treatment, as well as if it is necessary to increase the effects of other diuretics), cirrhosis of the liver (accompanied by edema and/or ascites), nephrotic syndrome (if treatment of the underlying disease is ineffective, limiting consumption table salt and fluids, as well as when using other diuretics);

Essential arterial hypertension (in combination with other antihypertensive drugs; the use of the drug is preferable for hypokalemia);

Hypokalemia (if it is impossible to use other methods of correcting potassium levels, including to prevent hypokalemia during treatment with digitalis preparations).

Dosage regimen

At primary hyperaldosteronism during preparation for surgery Veroshpiron prescribed in a daily dose of 100-400 mg. If for some reason surgical treatment not carried out, long-term use is possible Veroshpirona at the minimum effective dose (the initial dose of the drug is reduced every 14 days to the lowest dose that has an effect). At long-term use to reduce the risk of side effects, it is advisable to prescribe Veroshpirona in combination with other diuretics.

At edema syndrome in chronic heart failure, liver cirrhosis, nephrotic syndrome the drug is prescribed adults in the initial daily dose of 100 mg, divided into 2 doses. In the future, depending on the clinical effectiveness, the daily dose can be reduced to 25 mg or increased to 200 mg.

If the expected diuretic effect is not observed, it is advisable to prescribe a diuretic acting on the proximal renal tubules. Dose Veroshpirona in this case it is recommended not to change.

For children The daily dose of the drug is 3 mg/kg body weight (in 1 or 2 doses).

At essential arterial hypertension The initial daily dose is 50-100 mg (divided into 2 doses). The duration of treatment is at least 2 weeks (since during this time the maximum hypotensive effect develops). Then an individual dose adjustment of the drug is carried out. Recommended use Veroshpiron in combination with other antihypertensive drugs.

At hypokalemia Veroshpiron used in a daily dose of 25-100 mg, if oral administration of potassium supplements and other methods of replenishing its deficiency are ineffective.

Side effect

From the side of water-electrolyte balance: hyperkalemia, hyponatremia, electrolyte imbalance.

From the endocrine system: at long-term treatment in men - gynecomastia and decreased erection; in women - engorgement of the mammary glands, menstrual irregularities; It is possible to change the timbre of the voice in both men and women.

From the digestive system: rarely - nausea, vomiting, diarrhea, gastritis, stomach ulcers and duodenum, gastritis, gastric bleeding.

From the side of the central nervous system: rarely - ataxia, lethargy, headache.

Dermatological reactions: rarely - maculopapular rash, erythema.

Side effects usually regress after discontinuation of the drug.

Contraindications to the use of the drug VEROSHPIRON

Use for liver dysfunction

Use for renal impairment

It is prohibited to take the drug in case of acute renal failure and severe renal dysfunction (KR<10 мл/мин).

Special instructions

Although the drug does not have a direct effect on carbohydrate metabolism, special caution is required when prescribing Veroshpirona with diabetes mellitus (especially complicated by diabetic nephropathy) due to the risk of developing hyperkalemia.

When using Veroshpirona in case of edematous syndrome, it is recommended to use other diuretics simultaneously, limit the intake of table salt and liquid, and, if necessary, maintain bed rest.

Due to the possibility of developing hyperkalemia, hyponatremia, hyperchloremic metabolic acidosis and a transient increase in blood urea nitrogen during the use of the drug, systematic monitoring of serum electrolytes and indicators of renal function is required.

It should be taken into account that against the background of the use Veroshpirona Determination of digoxin, cortisol and adrenaline in plasma and serum is difficult.

During the treatment period Veroshpiron alcohol consumption is prohibited.

According to some literature data in experimental studies in animals that were dosed over a long period of time Veroshpirona . Many times exceeding the maximum permissible dose for humans, the occurrence of cancer and myeloid leukemia was noted. Taking into account these data, it is recommended to avoid excessively prolonged use of the drug.

Impact on the ability to drive vehicles and operate machinery

In the initial period of use of the drug Veroshpiron Driving a car and other activities that require rapid psychomotor reactions are prohibited. In the future, the possibility of engaging in these types of activities is determined individually.

Overdose

Symptoms: nausea, vomiting, drowsiness, confusion, skin rash, diarrhea. Possible disturbance of water-electrolyte balance and dehydration of the body.

Treatment: there is no specific antidote. Symptomatic treatment of dehydration and water-electrolyte imbalance should be carried out by prescribing diuretics that increase potassium excretion, parenteral administration of a glucose solution (dextrose) with insulin. In severe cases, hemodialysis should be performed.

Drug interactions

When used simultaneously Veroshpirona with salicylates there is a decrease in the diuretic effect.

When used simultaneously Veroshpirona with other diuretics there is an increase in diuresis.

When used simultaneously Veroshpirona with antihypertensive drugs, the hypotensive effect may be enhanced.

When used simultaneously Veroshpirona with potassium supplements or potassium-sparing diuretics, the risk of developing hyperkalemia increases.

When used simultaneously Veroshpirona with NSAIDs the risk of developing hyperkalemia increases.

When used simultaneously Veroshpirona with ACE inhibitors and ammonium chloride, the risk of developing acidosis increases.

When used simultaneously Veroshpirona with fludrocortisone there is a paradoxical increase in tubular secretion of potassium.

When used simultaneously Veroshpirona with mitotane the effect of the latter decreases.

When used simultaneously Veroshpiron reduces the effect of indirect anticoagulants (coumarin derivatives).

When used simultaneously Veroshpirona with triptorelin, buserelin, gonadorelin, the effect of the latter is enhanced.

Pharmacokinetic interaction

When used simultaneously with Veroshpiron The half-life of digoxin increases. This can lead to an increase in the concentration of digoxin in the blood, up to toxic levels (if it is necessary to use them together, the dose should be reduced or the interval between doses of digoxin should be increased).

Conditions for dispensing from pharmacies

The drug is available with a prescription.

Veroshpiron - instructions for use, analogues, reviews, price

Description of the drug and composition

Preparation Veroshpiron is potassium-sparing diuretic. and has a pronounced and long-lasting diuretic effect. The active ingredient of this medicinal product is spironolactone(one of the hormones of the adrenal cortex). This substance has a long-lasting effect and can prevent the retention of water and sodium in the lower parts of the renal tubules. Veroshpiron does not have a significant effect on blood circulation in the kidneys, helps reduce the acidity of urine and reduces the excretion of potassium from the body.

The diuretic effect of this drug helps lower blood pressure. It begins to appear 2-5 days after starting to take Veroshpiron, and persists for 3 days after its discontinuation. After oral administration, spironolactone is completely absorbed from the digestive tract into the blood and enters the kidneys. providing a diuretic effect. The drug is excreted from the body mainly through urine and partly through feces.

Release forms

Verospiron is produced in Hungary by GEDEON RICHTER in the following dosage forms:

White (or almost white) tablets with a bevel, flat, round, on one side there is the marking “VEROSPIRON” - 25 mg each, 20 pieces in one blister, in a cardboard package.
Capsules with a yellow cap and a white body, hard, gelatin, with a granular fine-grained mixture of white color - 50 mg each, 10 pieces in a blister, 3 blisters in a cardboard package.
Capsules with an orange cap and a yellow body, gelatin, hard, with a granular fine-grained mixture of white color - 100 mg each, 10 pieces in a blister, 3 blisters in a cardboard package.

Instructions for use of Veroshpiron

Indications for use

Edema syndrome due to heart failure (alone or in combination with other drugs and diuretics);
essential hypertension (as part of complex therapy);
for the prevention of hypokalemia while taking other diuretics;
Conn's syndrome (primary hyperaldosteronism);
conditions of secondary hyperaldosteronism (ascites and edema in liver cirrhosis, nephrotic syndrome, etc.);
to perform diagnostic tests for hyperaldosteronism.

Contraindications

Children under 3 years of age;
pregnancy period;
breastfeeding period;
anuria (impaired urine excretion up to its complete absence);
lactose intolerance or lactase deficiency;
galactose and glucose malabsorption syndrome;
Addison's disease;
severe forms of renal failure;
hyponatremia;
hyperkalemia;
hypersensitivity to one of the components of the drug.

Veroshpiron is prescribed with caution when:

Side effects

From the nervous system– lethargy, headaches and dizziness. ataxia, drowsiness, confusion, lethargy.
From the digestive organs– nausea, diarrhea, constipation. colic and abdominal pain. vomiting, gastritis. intestinal or stomach bleeding. liver dysfunction.
From the blood side– thrombocytopenia. megablastosis, agranulocytosis.
From the endocrine organs– in women, menstrual irregularities (dysmenorrhea, metrorrhagia during menopause, amenorrhea), pain in the mammary glands. hirsutism. breast cancer, in men – gynecomastia.
From the immune system– allergic reactions in the form of drug fever, itching. hives. erythematous and papular rash.
From the kidneys– acute renal failure.
From the muscular system– muscle spasms, cramps of the calf muscles.
From the skin and hair– hypertrichosis (excessive hair growth), baldness.
Metabolic disorders– increase in blood urea level. creatinine and uric acid. decreased blood sodium levels, hyperchloremic alkalosis or acidosis.

In most cases, after discontinuation of Veroshpiron, side effects gradually disappear.

Treatment with Veroshpiron

How to take Veroshpiron?

Veroshpiron is taken orally in the recommended dosage and washed down with a sufficient amount of water. Tablets or capsules are swallowed whole without chewing. It is advisable to take the drug in the morning or during the day, since taking it before bedtime will disrupt your usual routine.

It is recommended to take Veroshpiron simultaneously with meals or immediately after them. If you miss a dosage, if no more than 4 hours have passed since the prescribed time, you must immediately take the missed dose of the drug. In other cases, you should take the medicine in the usual dosage during your next appointment.

While taking Veroshpiron, it is recommended to avoid consuming excessive amounts of salt and foods rich in potassium (apricots, tomatoes, peaches, dates, oranges, coconuts, grapefruits, bananas, prunes). During treatment with this drug, the consumption of alcoholic beverages is prohibited.

In the initial period of taking Veroshpiron, it is necessary to abandon activities that require speed of psychomotor reactions and increased attention (driving vehicles, working with complex mechanisms, etc.). The duration of such restrictions depends on the individual characteristics of the patient’s health condition.

When prescribing Veroshpiron to elderly people and patients with severe kidney and liver diseases, constant laboratory monitoring of kidney function and the level of electrolytes in the blood serum is recommended. The same monitoring is necessary for patients who are receiving non-steroidal anti-inflammatory drugs while taking this diuretic. If necessary, the doctor can adjust the dose of the drug.

Dosage

The dosage and duration of taking Veroshpiron is determined only by a doctor, and depends on the diagnosis and severity of the condition:

Essential hypertension - 50-100 mg once a day, then the dose can be gradually increased to 200 mg (once every 2 weeks), duration of administration is at least 2 weeks.
Idiopathic hyperaldosteronism – 100-400 mg once a day.
Severe hyperaldosteronism and hypokalemia – 300-400 mg 2-3 times a day; then, as the condition improves, the dose can be reduced to 25 mg per day.
Edema in nephrotic syndrome – 100-200 mg per day.
Edema in heart failure - 100-200 mg 2-3 times a day, for 5 days in combination with thiazide diuretics; then the maintenance dosage can be reduced to 25 mg (determined individually).
Edema in liver cirrhosis - the dose of Veroshpiron depends on the ratio of Na+/K+ ions in the urine. If this ratio is greater than 1.0, 100 mg is prescribed once a day; if the ratio is less than 1.0, 200-400 mg is recommended once a day; then the maintenance dose is determined individually.
Diagnostic test for hyperaldosteronism - 400 mg per day, divided into several doses, taken for 4 days. For a long-term test, it may be recommended to take 400 mg per day for 3-4 weeks.
Preoperative preparation for primary hyperaldosteronism - 100-400 mg per day, divided into 2-3 doses; The duration of treatment is determined individually.

Overdose

An overdose of Veroshpiron is manifested by the following symptoms:

nausea and vomiting;
diarrhea;
skin rash;
confusion;
drowsiness;
dehydration of the body.

If the above symptoms are detected, the patient should rinse the stomach (induce vomiting) and consult a doctor. There is no specific antidote for Veroshpiron. To help the patient, symptomatic therapy is carried out.

Veroshpiron for children

Veroshpiron can be used in pediatric practice as a diuretic for various diseases. The dosage and duration of its use is determined only by the doctor, and the child’s parents must strictly follow all medical recommendations.

Despite the fact that the contraindications for this drug indicate a restriction for use by children under 3 years of age, in practice the drug is in some cases prescribed to younger children (including infants). However, treatment with Veroshpiron for children in this age group is carried out in a hospital setting or under strict medical supervision.

Dosage of Veroshpiron for edema in children:

1. The initial daily dose is 1-3 mg/kg for 1-4 doses.

2. After 5 days, the initial dose can be adjusted (if necessary, it can be increased 3 times).

In some cases, especially in infants. after taking Veroshpiron, vomiting occurs. If it appears earlier than half an hour after administration, the child must be given another dose of the drug. If more than half an hour has passed from the time of administration to the attack of vomiting, then there is no need to give another dose.

An overdose of Veroshpiron is especially dangerous in young children. It is accompanied by an increase in many side effects. The child becomes increasingly sleepy. weakness, heart rhythm disturbances or seizures may occur. Signs of dehydration are also detected: lack of saliva, the skin becomes dry, and there may be vomiting or diarrhea. In such cases, it is urgent to stop taking the drug, rinse the child’s stomach and call a doctor or an ambulance.

Use during pregnancy and lactation

Taking Veroshpiron is contraindicated for women during pregnancy and lactation.

If it is necessary to prescribe this drug to nursing mothers, it is recommended to stop breastfeeding. because spironolactone can penetrate into milk and have a negative effect on the child’s body.

Veroshpiron for weight loss

On the Internet and in some media you can find recommendations for taking Veroshpiron for weight loss. Despite the fact that this diuretic drug can get rid of several kilograms by removing fluid from the body, using it for weight loss is strictly prohibited. In addition, the loss of body weight does not occur due to the loss of adipose tissue, and the fluid removed after taking Veroshpiron is easily restored in the coming days.

This diuretic helps remove sodium and calcium ions from the body and causes dehydration. Loss of electrolytes can lead to seizures and cardiac dysfunction, while dehydration can lead to disruption of all body functions. These problems can bring those who want to lose weight this way to the intensive care unit and cause serious health problems in the future.

Also, taking Veroshpiron for the purpose of losing weight may be accompanied by a number of side effects of this drug:

tendency to bleed;
liver dysfunction;
diarrhea, vomiting and nausea;
menstrual irregularities in women or gynecomastia in men;
stomach diseases, etc.

We should not forget that uncontrolled use of this diuretic by people with certain kidney diseases can lead to the development of kidney failure and cause the movement of stones through the urinary tract.

Remember! Taking Veroshpiron and other diuretics for the purpose of losing weight is absolutely unjustified and dangerous!

Drug interactions of Veroshpiron

When prescribing Veroshpiron, you should inform your doctor about taking other medications, since this drug can interact with many of them.

Veroshpiron:

reduces the effectiveness of anticoagulants (coumarin derivatives, Heparin, Indandione);
reduces the toxicity of cardiac glycosides (Strophanthin K, Digitoxin, Celanide, Korglikon, etc.);
reduces vascular sensitivity to Norepinephrine;
reduces the effectiveness of Mitotane;
enhances the effectiveness of antihypertensive and diuretic drugs;
enhances the metabolism of Phenazol;
increases the toxicity of lithium-containing drugs;
accelerates the elimination of Carbenoxolone, and their combined use leads to sodium retention;
enhances the effect of Buserelin, Triptorelin and Gonadorelin;
when taken simultaneously with salicylates, the diuretic effect of the drug decreases;
when taken with potassium-sparing diuretics or potassium-containing drugs, Indomethacin. aldosterone blockers, angiotensin II antagonists and cyclosporines pose a risk of developing hyperkalemia;
when taken with cholestyramine and ammonium chloride, the risk of developing acidosis increases;
when taken with nonsteroidal anti-inflammatory drugs, there is a risk of developing hyperkalemia;
when taken with Fludrocortisone, increased secretion of potassium in the renal tubules develops; combined use with Digoxin can lead to a slower elimination of the latter and cause its toxic effect on the body.

Analogues of Veroshpiron

Analogs (synonyms) of Veroshpiron, which contain the same active component spironolactone, are:

Aldactone (UK);
Vero-Spironolactone (Russia);
Veroshpilakton (Russia);
Spirix (Denmark);
Spironaxane (UK);
Spironol (Russia);
Spironolactone (Russia);
Spironolactone (Unilan) (USA);
Urakton (Italy).

Veroshpiron is a high-quality diuretic drug that compares favorably with other diuretics in its effect on the level of potassium in the body. Mechanism of action: spironolactone (the active compound of the drug) affects the adrenal cortex, thereby blocking the hormone aldosterone, which is responsible for removing potassium from the body during water retention. Potassium remains in the body, while water is excreted with sodium and chlorine. After entering the body, it is absorbed into the gastrointestinal tract. The drug is excreted from the body through urine and feces.

The drug is marketed in the form of capsules and tablets.

What does Veroshpiron help with?

The medicine is not dispensed without a doctor's prescription. Typically, this diuretic is prescribed to eliminate edema and reduce blood pressure in heart failure. The drug may also be prescribed to identify problems associated with increased activity of the adrenal cortex (hyperfunction). The drug is also actively used if there is a need to remove excess sodium or chlorine ions from the body. In combination, it can be prescribed for essential hypertension as a drug that improves blood circulation and thereby lowers blood pressure. If surgery is planned for Conn's Syndrome, the drug may be prescribed for several days before surgery.

How and how much to take

If you are using the drug to relieve swelling due to disorders of the cardiovascular, renal and other systems, then Veroshpiron should be taken from 110 to 190 mg per day for adults. Children at least three years old should take the drug at a rate of 1.1-3.2 mg/kg body. After approximately five days, the dosage should be adjusted, coordinating it with the result.

In case of treatment of problems with the adrenal glands with the drug, 390 mg per day is prescribed three to four times a day for four days. Approximately the same dosage of the drug is prescribed in case of testing for hyperaldosteronism. In such cases, the medicine should be taken for about 20-30 days.

If the drug is used to normalize the ionic balance, possibly disturbed by other diuretics, then the medicine should be taken from 30 to 90 mg/day. If hypokalemia is clearly visible, the initial dose is prescribed at 300 mg/day. Guided by further tests, the dosage is slowly reduced.

The daily dose of Veroshpiron should not exceed 400 mg.

In what cases should you refrain from taking

The drug is inappropriate for excess potassium, lack of sodium, Addison's disease, kidney problems, allergies, pregnancy and breastfeeding.

You should think carefully before taking the drug:

for diabetes
for general and local anesthesia
for liver damage associated with cirrhosis
for irregular menstruation
old people

If the drug cannot be discontinued if you are breastfeeding, you should stop breastfeeding.

Side effects

The drug is often well tolerated by humans; side effects are observed in case of overdose. In case of an overdose, a person may experience dizziness, an allergic reaction, arrhythmia, nausea and vomiting, dry mouth, thirst, and weakness. In case of poisoning, perform gastric lavage.

We hope that we have helped you with this article. We hope that you understand what Veroshpiron is and why it is taken. We wish you good health.

otchego.net

"Veroshpiron" - a diuretic or not? "Veroshpiron": reviews

Taking antihypertensive drugs in most cases is due to deteriorating health, poor diet and old age, which causes hypertension. In our time, hypertension is called a “slow killer”: it wears out blood vessels and the heart gradually, without causing harm with sudden attacks, with the exception of hypertensive crises. Diuretic tablets "Veroshpiron" are a popular solution for reducing the volume of circulating fluid. But is it safe to take them?

Blood pressure concept

Blood pressure, hereinafter referred to as blood pressure, is one of the main vital indicators, determined by the need to transport blood through vessels to organs and tissues. Probably everyone knows that there is “upper” and “lower” pressure: these two numbers, measured with a tonometer, characterize blood pressure at two points.

The first, systolic, at the moment of ejection of blood by the heart. The second, diastolic, at the moment of relaxation of the heart muscle. How does the drug “Veroshpiron” help in adjusting blood pressure? Is this a diuretic or not? Let's figure it out.

Group of antihypertensive drugs

Drugs that affect the innervation of the heart and blood vessels. The contraction of the heart muscle and blood vessels can be regulated. More precisely, innervation can be regulated. Take, for example, the well-known “white coat hypertension”, when patients show higher indicators when they see doctors: by worrying, they (the patients) thereby “inflate” their indicators. Anti-anxiety medications can reduce blood pressure by eliminating stress-induced vasodilation.
Diuretics. Diuretic tablets "Veroshpiron" (reviews of the effectiveness of this drug can be found on many forums) are a typical representative of diuretic drugs. The action of the drug is aimed at reducing the volume of circulating fluid, which is the direct cause of the decrease in pressure.

"Veroshpiron" (diuretic): reviews, description of the drug and active substance

The active ingredient of the drug "Veroshpiron" is spironolactone. This substance is also found in medicinal analogues of “Veroshpiron”: “Spirix”, “Uractone”, “Aldactone”. There are also a number of drugs based on spironolactone against hair loss.

Preparations containing spironolactone, in addition to arterial hypertension, are used against a fairly wide range of diseases. These include, for example, edema syndrome in heart failure. For "Veroshpiron", a diuretic, reviews and ratings from doctors in the treatment of such diseases are quite favorable. Systematic treatment with drugs of this group has a positive effect on the dynamics of blood pressure, and also helps eliminate the phenomenon of swelling by reducing the volume of extracellular fluid. In addition, a group of these diuretics may be effective in the event of development of resistance (immunity) to other diuretics (Furosemide, for example).

"Veroshpiron" - a diuretic or not? Hormonal aspects of drug use

It is known that, in addition to therapeutic use, spironolactone is also used in trichological practice. The effectiveness of the active substance as an antiandrogenic is known and proven. That is, an antagonist of the male sex hormone aldosterone. But in undesirable cases, the drug also has a feminizing effect on the body. The main effect of the drug "Veroshpiron" is diuretic. But the side effect is hormonal. Patients with gynecomastia – enlarged mammary glands – were especially surprised. It should be borne in mind that the drug affects the endocrinological functions of the body, and in order to avoid side effects it should be taken with caution.

Practice of using "Veroshpiron"

"Veroshpiron" is a drug found in all therapeutic departments of the country. Most doctors use the drug as a “battery” in case of ascites and edema of unknown origin. However, the drug is contraindicated for people with weakened kidneys and liver, as it puts additional stress on these organs. Also, due to the hormonal effects of the drug, people with menstrual irregularities are not recommended to use veroshpiron. The diuretic drug, however, is compatible with most foods and does not require a special diet. Not recommended for use by pregnant and lactating women, since hormonal changes can adversely affect the development of the fetus (in pregnant women). In nursing women, it is possible for the drug to enter the baby's body through milk.

In resolving the issue: “Is Veroshpiron a diuretic or not?” You can definitely come to an answer based on the Register of Medicines. According to him, the drug is a diuretic. The hormonal effect of the drug is considered in the context of side effects. However, spironolactone is currently undergoing a new wave of clinical trials in the field of cosmetology and dermatology.

Spironolactone: prospects for using the substance

What is the drug based on spironolactone, “Veroshpiron”? Is this remedy a diuretic or not? Or maybe hormonal?

The drug affects many functions in our body indiscriminately and, in addition to lowering blood pressure, can cause erectile dysfunction. The hormonal effects of this drug are used by many for other purposes. Persons wishing to improve the appearance of their hair or feminize the body (improved hair appearance, smooth skin, breast enlargement) often use this drug uncontrolled. In the near future, it is planned to release Veroshpiron exclusively by prescription in order to protect people from its uncontrolled use.

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Veroshpiron

Veroshpiron is a diuretic drug that is used to eliminate various edema. The medicine belongs to the group of potassium-sparing diuretics. The active substance is spironolactone, after which the drug is called Spironolactone on the international pharmacological market.

Veroshpiron is available in the following dosage forms:

Tablets containing the substance 25 mg;
Hard gelatin capsules of 50 and 100 mg.

Pharmacological properties of Veroshpiron

According to the instructions, Veroshpiron is a competitive antagonist of the mineralocorticoid aldosterone, a special hormone produced by the adrenal cortex. The medicine produces a pronounced diuretic effect, but does not significantly affect renal blood circulation and the functioning of the renal tubules, and does not disrupt the acid-base state in the body.

After oral administration, the medicine is completely and quickly absorbed from the gastrointestinal tract. The bioavailability of Veroshpiron, according to the instructions, reaches almost 100 percent, and food intake makes this figure maximum. The highest content of the drug in the blood is 80 ng/ml, subject to daily use of a dose of 100 mg for two weeks. After the next dose in the morning, Cmax is observed after 2-6 hours.

The drug binds to blood proteins by 98 percent. The active component spironolactone penetrates tissues and organs poorly, but it has the ability to penetrate the placental barrier in its original form and in the form of metabolites. The drug is also found in mother's breast milk.

The half-life of Veroshpiron, according to the instructions, is 13-24 hours. For the most part, the drug is excreted in the urine - 50% of the dose taken in the form of metabolites and unchanged - 10%. Minor excretion occurs through the intestines. Canrenone (the active metabolite of spironolactone) leaves the body in two stages: within 2-3 hours after administration - half and within 12-96 - the remaining amount.

In heart failure and liver cirrhosis, the half-life of Veroshpiron increases without signs of accumulation, the risk of which is higher with hyperkalemia and renal failure.

Indications for use

Indications for Veroshpiron are the following diseases:

Ascites associated with liver cirrhosis;
Edema caused by diseases of the heart and endocrine system: chronic heart failure, hirsutism, Conn's disease, polycystic ovary syndrome;
Arterial hypertension;
Severe burns;
Brain swelling;
Diseases accompanied by edema of various origins;
Myasthenia;
Paroxysmal paralysis associated with calcium deficiency.

Directions for use and dosage

The indications for Veroshpiron described above are only guidelines, therefore treatment with this drug is prescribed only by a doctor.

For liver cirrhosis, the dosage of the drug is 0.1, 0.2 or 0.4 g per day and depends directly on the stage and characteristics of the course of the disease.

For nephrotic syndrome, the use of Veroshpiron involves doses of 0.1 to 0.2 g per day. To treat edema syndrome, it is recommended to take the medicine at a dose of 100-200 mg in three doses. According to the instructions, Veroshpiron should be taken every day for 5 days, after which the daily dosage is gradually reduced to 25 mg or increased to 400 mg in 4 doses.

To reduce high blood pressure, doses of the drug range from 50 to 100 mg per day, and the medicine is taken either once a day or in 4 divided doses. The course of treatment lasts 2 weeks. Reviews of Veroshpiron confirm that the drug is allowed to be combined with antihypertensive drugs.

For hypokalemia, the use of Veroshpiron is indicated in an amount of 25-100 mg at a time or up to 400 mg per day, divided into several doses.

Doses of the drug for primary hyperaldosteronism are 0.1, 0.2 or 0.4 mg per day, divided into 4 doses - before surgery and 25-50 mg - for long-term treatment.

To eliminate polycystic ovary syndrome and hirsutism, the dose of Veroshpiron is 100 mg 2 times a day.

Children are prescribed 1-3.3 mg per kg of weight, and this amount is taken either fractionally (4 doses) or once. After 4 days of treatment, the dose is adjusted, and it can be increased threefold. When a clinical effect is achieved, the dosage is reduced to 25 mg per day, after which the drug is taken 1 tablet 4 times a day every 4 days.

Side effects

According to reviews of Veroshpiron, the following disorders in the body are possible:

From the peripheral and central nervous system: lethargy, headaches and dizziness, ataxia, lethargy, drowsiness, confusion;
From the gastrointestinal tract: diarrhea, gastritis, nausea and vomiting, the appearance of ulcers and bleeding in the gastrointestinal tract, constipation, abdominal pain, impaired liver function;
From the hematopoietic organs: thrombocytopenia, agranulocytosis and megaloblastosis;
Metabolism: hypercreatininemia, metabolic hyperchloremic acidosis, alkalosis, hyperuricemia, increased urea concentration, hyponatremia, hyperkalemia;
From the endocrine system: gynecomastia in men (the phenomenon is reversible, quickly disappears when the drug is discontinued, in isolated cases the mammary gland may be slightly enlarged), deepening of the voice, decreased erection and potency; in women: dysmenorrhea, menstrual irregularities, pain in the mammary glands, hirsutism, metrorrhagia during menopause, amenorrhea;
Allergic reactions: itching, drug fever, rash, urticaria, maculopapular and erythematous rash (rare);
Dermatological disorders: hypertrichosis, alopecia;
From the excretory system: acute renal failure;
From the musculoskeletal system: cramps of the calf muscles, muscle spasms.

Overdose of Veroshpiron

It is extremely rare that reviews of Veroshpiron indicate cases of drug overdose. However, in such situations, you need to rinse the stomach, drink plenty of fluids, as well as caffeine in order to increase blood pressure. Patients with hyperkalemia are prescribed insulin and dextrose.

Contraindications to the use of Veroshpiron

Contraindications to Veroshpiron are:

Renal dysfunction;
Hypersensitivity to any component;
Diabetes mellitus with complications;
Addison's disease;
Increased levels of calcium and potassium in the blood;
Pregnancy;
Liver failure;
Gynecological diseases.

Veroshpiron is prescribed cautiously for conduction blockades in the heart muscle, taking hormonal medications, surgical interventions, and in elderly patients.

During treatment with this drug, you should limit the intake of potassium into the body, as well as monitor your blood condition and kidney function.

Conditions and shelf life

zdorovi.net

The drug "Veroshpiron": from what

The article describes the use of the drug "Veroshpiron", for which it is not recommended to take it. It also contains information about contraindications and side effects.

Annotation

The drug "Veroshpiron": what is it used for?

The main purposes of the drug are:

Polycystic ovary syndrome, premenstrual syndrome, hirsutism
Diagnosis of hyperaldosteronism
Myasthenia (auxiliary drug)
Aldosterone-producing adrenal adenoma
Arterial hypertension
Primary hyperaldosteronism
Hypokalemia
Edema syndrome, nephrotic syndrome, liver cirrhosis, edema during pregnancy

Contraindications to the use of the drug "Veroshpiron"

It is prohibited to prescribe medication for a diagnosis of:

Addison's disease
hyperkalemia,
Hypersensitivity,
hypercalcemia,
anuria,
hyponatremia,
metabolic acidosis,
pregnancy (first trimester),
diabetic nephropathy,
enlargement of the mammary glands,
liver failure,
diabetes mellitus,
menstrual irregularities

Prescribed with caution in case of AV block (possibility of intensification due to the development of hyperkalemia), decompensated cirrhosis of the liver, surgical interventions, taking drugs that cause gynecomastia in old age.