Calcium d3 nycomed evidence-based medicine. Calcium D3 Nycomed: instructions for use

Calcium D3 Nycomed is a drug based on two main components - calcium and vitamin D3, which is also called cholecalciferol.

In turn, calcium is a vital element for teeth, bones, bone tissue, and even neurotransmission in the central and peripheral nervous system of humans. In addition, the drug balances the synthesis of parathyrin, a failure in the production of which can result in the appearance of periodic processes of destruction bone tissue.

On this page you will find all the information about Calcium D3 Nycomed: full instructions on application to this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Calcium D3 Nycomed. Would you like to leave your opinion? Please write in the comments.

Clinical and pharmacological group

A drug that regulates the metabolism of calcium and phosphorus.

Conditions for dispensing from pharmacies

Available without a prescription.

Prices

How much does Calcium D3 Nycomed cost? Average price in pharmacies it is at the level of 400 rubles.

Release form and composition

The drug is produced and released in the form chewable tablets with lemon, orange and mint flavors.

Orange flavored tablets are produced without a coating, o round shape And white. Calcium-D3 Nycomed with orange contains the main substances:

calcium carbonate – 1250 milligrams;
vitamin D3 – 5.0 mcg (200 IU);

and minor elements:

isomaltitol – 62.0 mg;
glucite – 390 mg;
orange olive – 0.97 mg;
di and monoglycerides of carboxylic fatty acids – 0.08 mcg.

The products are produced in boxes of 20, 50, 100 pieces per box.

The mint-flavored product, which is also available on store shelves, is completely similar in composition to orange tablets.

The only difference between them is that instead orange oil, the drug contains mint flavor essence. Available in polyethylene bottles high density 30 and 100 pieces.

Chewable tablets with lemon flavor are somewhat different from other types in their composition, and, more precisely, in the amount of elements they contain. They are called Calcium D3 Nycomed Forte.

Primary substances:

calcium carbonate – 1250 mg;
equivalent to regular Ca – 500 mg;
cholecalciferol – 10.0 mcg (400 IU);
colecalciferol concentrate – 4.0 mg;

and additional elements:

Zomaltit – 49.9 mg;
povidone (enterosorbent) – 36.4 mg;
magnesium stearate – 6.00 mg;
L-Aspartyl-L-phenylalanine – 1.00 mg;
glucite – 390 mg;
lemon oil – 0.78 mg;
di- and monoglycerides of carboxylic fatty acids – 0.0006 mg.

The product is released in polyethylene bottles of 30, 60, 120 pieces.

Pharmacological effect

The drug belongs to the combination pharmaceuticals, which regulate the exchange of calcium and phosphorus in the body and compensate for the deficiency of the main structural element.

The biochemical role of calcium lies in the physiological construction of bone tissue, mineralization of teeth, the processes of coagulation and transmission of nerve impulses, the implementation muscle contractions. In response to his promotion to systemic blood flow bone density increases, calcium excretion by the kidneys decreases.

Cholecalciferol is responsible for the absorption processes of the element in the gastrointestinal tract and its distribution in the body. Oral administration of the drug inhibits the synthesis of parathyroid hormone, a natural hormone. parathyroid gland, which significantly affects phosphorus-calcium metabolism. Accordingly, the amount of calcium absorbed from the digestive tube increases and its resorption (leaching) from bones and other organs decreases.

Indications for use

Taking Calcium D3 Nycomed tablets is indicated in the following cases:

Preventing the development of complications of osteoporosis - a pathological decrease in the level of minerals in bone tissue, which is accompanied by a significant decrease in its strength and frequent fractures.
Treatment and prevention of conditions that are associated with insufficient levels of calcium or vitamin D3 in the body (hypovitaminosis and hypocalcemia).

The indications for taking the drug are determined by the doctor based on clinical picture and results additional examination, confirming the presence pathological process in the body.

Contraindications

According to the instructions, Calcium D3 Nycomed cannot be used for:

hypercalcemia;
nephrolithiasis;
hypercalciuria;
severe renal failure;
active form of tuberculosis;
hypervitaminosis D;
sarcoidosis;
and also up to three years of age;
high level of sensitivity of the body to the components included in the drug, peanuts or soy.

The drug should also not be taken by people with phenylketonuria, since it contains aspartame, which is transformed in the body into phenylalanine.

It is also not recommended to take the drug for persons with glucose-galactose malabsorption, hereditary fructose intolerance, or sucrase-isomaltase deficiency, since the tablets of the drug contain isomalt, sorbitol, and sucrose.

Use during pregnancy and lactation

Calcium and vitamin D3 are used during pregnancy to compensate for their deficiency in the body.

During pregnancy, the daily dose of the drug should not exceed 1500 mg of calcium and 600 IU of vitamin D3. Hypercalcemia due to overdose during pregnancy may have an adverse effect on developing fetus.

The drug is used during lactation. Calcium and vitamin D3 can penetrate into breast milk, therefore it is necessary to consider the intake of calcium and vitamin D from other sources in the mother and child.

Instructions for use

The instructions for use indicate that Calcium D3 Nycomed tablets can be chewed or dissolved and taken with meals.

Adults for the prevention of osteoporosis - 1 tablet. 2 times/day; V complex therapy osteoporosis – 1 tablet. 2-3 times/day.
To replenish calcium and vitamin D deficiency, adults and children over 12 years old – 1 tablet. 2 times a day, children from 5 to 12 years old - 1-2 tablets per day, children from 3 to 5 years old - dosage in accordance with the doctor’s recommendations.

Duration of treatment:

When used for prevention and in complex therapy of osteoporosis, the duration of treatment is determined by the doctor individually.
When used to compensate for calcium and vitamin D3 deficiency average duration course of treatment for at least 4-6 weeks. The number of repeat courses during the year is determined individually.

Patients with impaired liver function do not require dose adjustment.

Should not be used in severe renal failure.

Elderly patients are prescribed the same dose as for adults. A possible decrease in CC should be taken into account.

Side effects

During therapy, undesirable reactions may occur:

Allergic reactions: very rare - skin rashes, itching, urticaria;
Laboratory indicators: infrequently – hypercalciuria and hypercalcemia ( increased content calcium in urine or blood);
From the outside digestive system: rarely – dysfunction gastrointestinal tract(increased formation of gases in the intestines, abdominal pain, nausea, dyspepsia, diarrhea or constipation).

Overdose

An overdose of calcium is fraught with the development of hypercalcemia, its symptoms: thirst, muscle weakness, abdominal pain, constipation, nausea, vomiting, polyuria, increased fatigue, anorexia, bone pain, urolithiasis, nephrocalcinosis, mental disorders. In severe cases, cardiac arrhythmias are added.

At long-term use in excessive doses (more than 2500 mg of calcium), kidney damage and soft tissue calcification are possible. If any of the described symptoms appear, you should stop taking Calcium-D3 Nycomed and consult a doctor. First aid for overdose involves gastric lavage, then a loop diuretic (for example, furosemide), a glucocorticosteroid, calcitonin and bisphosphonates are prescribed, and replenishment of lost fluid is also indicated. It is necessary to monitor diuresis, renal function and electrolyte levels in the blood; in severe cases, ECG monitoring and measurement of central venous pressure.

Hypercalcemia resulting from overdose during pregnancy may have adverse effects on the fetus.

Special instructions

To avoid overdose, it is important to consider additional vitamin D intake from any other sources, including food.
It is not recommended to prescribe quinolone and tetracycline antibiotics at the same time. If the use of such combinations is justified, caution should be exercised.
The drug should be used with caution in the treatment of patients with osteoporosis if they are immobilized, since this category is susceptible to increased risk development of hypercalcemia.

At long-term use of the drug, it is necessary to monitor the level of calcium and creatinine in the blood serum, especially in elderly people receiving concomitant diuretics and/or cardiac glycosides, as well as in patients with an increased tendency to form kidney stones. If symptoms of impaired renal function or the development of hypercalcemia appear, the dose of Calcium-D3 Nycomed Forte should be reduced or discontinued altogether.

Drug interactions

Calcium absorption is reduced by glucocorticosteroids, so an increase in the dose of the supplement may be required.

Developed as a result of taking mineral supplement hypercalcemia may potentiate the toxic effects of cardiac glycosides. Monitoring serum calcium concentration and ECG monitoring is necessary.

Calcium reduces absorption and reduces the effectiveness of levothyroxine, so the interval between doses should be at least 4 hours. Bisphosphonates, if necessary, are recommended to be taken no later than 1 hour before taking Calcium-D3Nycomed.

It is not recommended to take the drug simultaneously with tetracycline antibiotics and quinolone, since their absorption is reduced. If such a combination is still necessary, it is recommended to take these medications 2 hours before or 4-6 hours after taking Calcium-D3Nycomed. The patient must be under close medical supervision throughout the entire treatment period.

The risk of developing hypercalcemia increases with simultaneous use of thiazide diuretics. In this case, it is necessary to regularly monitor the concentration of calcium in the blood serum.

Name: Calcium-D3 Nycomed

Active ingredient

Calcium carbonate + Colecalciferol*

ATX

A12AX Calcium supplements in combination with vitamin D and/or other medications

Pharmacological groups

Calcium-phosphorus metabolism regulator [Bone and bone metabolism correctors cartilage tissue in combinations]
Calcium-phosphorus metabolism regulator [Vitamins and vitamin-like products in combinations]

Compound

Description of the dosage form

Round, biconvex, uncoated, white tablets with orange or mint flavor. May have small inclusions and uneven edges.

Pharmacological action

Pharmacological effect - replenishes the deficiency of calcium and vitamin D3.

Pharmacodynamics

A combined drug that regulates the exchange of calcium and phosphorus in the body (bones, teeth, nails, hair, muscles). Reduces resorption (resorption) and increases bone density, replenishing the lack of calcium and vitamin D3 in the body, necessary for the mineralization of teeth. Calcium is involved in the regulation nerve conduction, muscle contractions and is considered a component of the blood coagulation system.

Vitamin D3 increases calcium absorption in the intestines. The use of calcium and vitamin D3 interferes with the production of parathyroid hormone (PTH), which is believed to stimulate increased bone resorption (leaching of calcium from the bones).

Pharmacokinetics

Calcium

Suction. Often, the amount of calcium absorbed in the gastrointestinal tract is somewhere around 30% of the dose taken.

Distribution and metabolism. 99% of the calcium in the body is concentrated in the rigid structure of bones and teeth. The remaining 1% is found in intra- and extracellular fluids. About 50% of the total calcium content in the blood is in a physiologically active ionized form, of which about 10% is complexed with citrate, phosphate or other anions, the remaining 40% is associated with proteins, primarily albumin.

Excretion. Calcium is excreted by the intestines, kidneys and sweat glands. Renal excretion depends on glomerular filtration and tubular reabsorption of calcium.

Vitamin D3

Suction. Vitamin D3 is easily absorbed into small intestine(about 80% of the accepted dosage).

Distribution and metabolism. Colecalciferol and its metabolites circulate in the blood bound to a specific globulin. Colecalciferol is converted in the liver by hydroxylation to 25-hydroxycolecalciferol. Then converted in the kidneys to active form 1,25-hydroxycolecalciferol. 1,25-hydroxycolecalciferol is considered a metabolite responsible for increasing calcium absorption.

Unmetabolized vitamin D3 is stored in fat and muscle tissue.

Excretion. Vitamin D3 is excreted by the intestines and kidneys.

Indications for the drug Calcium-D3 Nycomed

prevention and treatment of calcium and/or vitamin D3 deficiency;

prevention and complex therapy of osteoporosis and its complications.

Contraindications

hypersensitivity to the components of the drug;

hypersensitivity to soy or peanuts;

hypercalcemia, hypercalciuria;

nephrolithiasis;

hypervitaminosis D;

severe renal failure;

active form of tuberculosis;

sarcoidosis;

children's age (up to 3 years).

With caution:

pregnancy;

lactation period.

renal failure.

Calcium-D3 Nycomed contains aspartame, which is transformed into phenylalanine in the body. Therefore, the drug should not be taken by patients with phenylketonuria.

The drug contains sorbitol, isomalt and sucrose, so its use is not recommended for patients with hereditary fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase deficiency.

Use during pregnancy and breastfeeding

Calcium-D3 Nycomed is used during pregnancy to replenish calcium and vitamin D deficiency in the body.

The daily dosage should not exceed 1500 mg of calcium and 600 IU of vitamin D3.

Hypercalcemia that develops against the background of an overdose during pregnancy can have an adverse effect on the developing fetus.

Calcium-D3 Nycomed is used during lactation.

Vitamin D and its metabolites can pass into breast milk, so the intake of calcium and vitamin D from other sources in the mother and baby must be considered.

Side effects

Itching, rash, urticaria, gastrointestinal dysfunction (constipation or diarrhea, flatulence, nausea, abdominal pain, dyspepsia), hypercalcemia and hypercaliciuria.

Interaction

Hypercalcemia may potentiate the toxic effects of cardiac glycosides when used concomitantly with calcium and vitamin D medications. Monitoring of ECG and serum calcium levels is necessary.

Calcium supplements may reduce the absorption of tetracyclines from the gastrointestinal tract. Therefore, tetracycline drugs should be taken at least 2 hours before or 4–6 hours after taking Calcium-D3 Nycomed.

To prevent decreased absorption of bisphosphonate drugs, it is recommended to take them at least an hour before taking Calcium-D3 Nycomed.

GCS reduce calcium absorption, so treatment with GCS may require an increase in the dosage of Calcium-D3 Nycomed.

With the simultaneous use of thiazide diuretics, the risk of hypercalcemia increases, because they increase tubular reabsorption of calcium. When using thiazide diuretics simultaneously, serum calcium levels should be regularly monitored.

Calcium reduces the effectiveness of levothyroxine by reducing its absorption. The period of time between doses of levothyroxine and Calcium-D3 Nycomed should be at least 4 hours.

The absorption of quinolone antibiotics is reduced when used simultaneously with calcium medications. Therefore, quinolone antibiotics should be taken 2 hours before or 6 hours after taking Calcium-D3 Nycomed.

Ingestion of foods containing oxalates (sorrel, rhubarb, spinach) and phytin (cereals) reduces the absorption of calcium, so you should not take Calcium-D3 Nycomed within 2 hours after eating sorrel, rhubarb, spinach, cereals.

Directions for use and doses

In complex therapy of osteoporosis: adults - 1 tablet. 2-3 times a day; to prevent osteoporosis - 1 table. 2 times a day.

For calcium and vitamin D deficiency: adults and children over 12 years old - 1 tablet. 2 times a day; children from 5 to 12 years old - 1–2 tablets. per day; 3–5 years - dosage in accordance with doctor’s recommendations.

Special groups patients

Patients with impaired liver function. No dosage adjustment is required.

Patients with impaired renal function. The drug Calcium-D3 Nycomed should not be used in case of severe renal failure.

Elderly patients. The dosage is the same as for adults. A possible decrease in creatinine clearance should be taken into account.

Duration of treatment. When used for the prevention and complex therapy of osteoporosis, the duration of treatment is determined by the doctor individually.

When used to replenish calcium and vitamin D3 deficiency, the average duration of treatment is at least 4–6 weeks. The number of repeat courses during the year is determined individually.

Overdose

Symptoms of overdose (hypercalcemia): anorexia, thirst, polyuria, muscle weakness, nausea, vomiting, constipation, abdominal pain, fatigue, bone pain, mental disorders, nephrocalcinosis, urolithiasis and, in severe cases, cardiac arrhythmias. At long-term use excessive doses (over 2500 mg of calcium) - kidney damage, soft tissue calcification.

If signs of overdose are detected, you should stop taking calcium and vitamin D, as well as thiazide diuretics and cardiac glycosides, and consult a doctor.

Treatment: gastric lavage, replenishment of fluid loss, use of loop diuretics (in particular furosemide), corticosteroids, calcitonin, bisphosphonates. It is necessary to monitor the content of electrolytes in the blood plasma, kidney function and diuresis. In severe cases, measurement of central venous pressure (CVP) and ECG monitoring are necessary.

Special instructions

At long-term therapy, the levels of calcium and creatinine in the blood serum should be monitored.

Monitoring is especially important in elderly patients during simultaneous treatment with cardiac glycosides and diuretics (see “Interaction”) and in patients with an increased tendency to form kidney stones. In cases of hypercalcemia or signs of renal dysfunction, reduce the dose or discontinue treatment.

Vitamin D should be taken with caution in patients with renal failure. In this case, it is necessary to monitor the calcium and phosphate levels in the blood serum. You also need to consider the risk of soft tissue calcification.

To avoid overdose, additional vitamin D intake from other sources must be taken into account.

Calcium and vitamin D3 should be used with caution in immobilized patients with osteoporosis due to the risk of hypercalcemia.

Concomitant use with tetracycline or quinolone antibiotics is often not recommended, or should be used with caution (see “Interactions”).

Release form

Chewable tablets (orange). 20, 50 or 100 tablets. in a HDPE bottle, sealed with a screw cap, under which there is a ring for tearing off the sealing gasket, ensuring control of the first opening. 1 fl. placed in a cardboard box.

Chewable tablets (mint). 30 or 100 tablets. in a HDPE bottle, sealed with a screw cap, under which there is a ring for tearing off the sealing gasket, ensuring control of the first opening. 1 fl. placed in a cardboard box.

Manufacturer

Nycomed Pharma AS, Norway.

Conditions for dispensing from pharmacies

Over the counter.

Storage conditions for the drug Calcium-D3 Nycomed

In a dry place, at a temperature not exceeding 25 °C, in a tightly closed bottle.

Keep out of the reach of children.

Shelf life of the drug Calcium-D3 Nycomed

Do not use after the expiration date stated on the packaging.

Calcium is very important for the human body. Thanks to it, iron is absorbed, joints and bones are strengthened, and work improves nervous system and sleep normalizes. In the absence of this important element The patient develops osteoporosis, teeth decay, and seizures occur. To compensate for calcium deficiency, you need to take medications based on this substance.

So unique medical device is Calcium D3 Nycomed. Thanks to this remedy, the patient will receive additional calcium and phosphate, as well as vitamin D3.

Description of the medical product

It is produced in the form of chewable strips with orange, lemon and mint flavors.

The medicine contains the following substances:

Calcium carbonate 1250 mg, which corresponds to regular calcium 500 mg in one tablet;
Colecalciferol or vitamin D3 in the amount of 200 IU.

Answer to the question: read here.

The product is available in plastic bottles 30, 60 and 120 pieces each. The tablet is round, convex with small inclusions and uneven edges.

Pharmacological action

Refers to the form of drugs with combined substances, in which contains calcium and vitamin D3. As you know, calcium is necessary for the formation of bone tissue, the normal functioning of joints and cartilage, and for dental health. Once in the stomach, the drug is evenly distributed throughout the body.

When taken orally, the drug is completely absorbed in the stomach and intestines. The bioavailability of tablets is approximately 30 percent. The drug is mainly metabolized in the liver to form metabolites. The active substances in the drug are excreted in urine and feces, and calcium is excreted through the sweat glands.

The drug is eliminated from the body within 24 hours. In this case, there is no irritation of the intestinal mucosa.

Indications

Prevention of osteoporosis;
Replenishment of vitamin D3 and calcium deficiency;
Appointed to joint reception with other drugs in the treatment of osteoporosis;
Prevention of fractures and injuries of bones and joints.

Contraindications

Severe pathology of the liver and kidneys;
High content of vitamin D3 in the body;
Hypersensitivity to the components of the drug;
Sarcoidosis;
Tuberculosis;
Phenylketonuria;
Urolithiasis;
Children under 5 years old;
Elderly people.

Dosage and course of treatment

Calcium tablets D3 Nycomed are prescribed for oral administration. The medicine has a pleasant orange, mint or lemon scent, which can be swallowed whole or chewed.

The remedy can be taken at any time and does not depend on food intake. The course of treatment depends on the severity of the disease and individual characteristics the patient's body. Children over 12 years old and adults Prescribe one tablet once or three times a day. The dosage is determined only by the doctor after examining and examining the patient.

Children over five and under 12 years old The medicine is prescribed to take one tablet once or twice a day. In the presence of osteoporosis in combination with other drugs, the drug is prescribed in a dose of one tablet two or three times a day.

To replenish vitamin D3, adults and children over 12 years of age are recommended to take two tablets per day. From 5 to 12 years, one tablet per day.

Overdose

When treated with the drug in large doses long period Hypercalcemia may develop.

Symptoms of the disease are:

Gag reflex;
Migraine;
Feeling dizzy;
Lack of appetite;
Increased weakness;
The creatinine level in the blood increases and the patient may fall into a coma;
Kidney failure.

At the first signs of overdose the patient is stopped taking the drug, the body is saturated a large number fluids and are prescribed to take special diet dream high content calcium. In more severe cases, it is necessary to prescribe somatic treatment and taking hormone therapy.

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Concomitant use with other groups of drugs

Other drugs containing calcium and vitamin D3;
Tetracycline antibiotics;
Barbiturates;
Corticosteroids;
Laxatives;
Diuretics.

Side effects

The drug is usually well tolerated, but in rare cases The following effects may occur:

Diarrhea;
Lack of appetite;
Nausea, vomiting;
Stomach pain;
Development allergic reactions, which manifest themselves in the form of rashes and itching on the skin.

Pain and crunching in the back over time can lead to dire consequences- local or complete restriction movements, even to the point of disability.

People, taught by bitter experience, use natural remedy which orthopedists recommend...

Drug price

The approximate price in the Russian Federation for the drug Calcium D3 Nycomed is:

Tablets in a package of 30 pieces – 239 rubles;
50 pieces per package – 317 rubles;
100 pieces each – 522 rubles;
20 pieces each – 171 rubles.

The cost of the drug may vary in different pharmacies. The drug is produced in Norway and has good taste and quite easy to use.

Reviews about the drug

Combination tablets enjoy in great demand among patients and doctors. Patients note that the tablets are convenient to take, they are tasty and do not cause heartburn.

In a short period Pain in joints and teeth ceases to bother you, which is characteristic of osteoparosis. Reviews from doctors are also highly rated. In the former, calcium and vitamin D3 in combination have a more pronounced effect.

Pharmacokinetic features, positive effects and quick results allow us to call this remedy one of the best among other drugs in the group.

Calcium D3 Nycomed - cheaper analogues

Pharmaceutical companies produce cheaper analogues of the drug Calcium D3 Nycomed:

Complivit calcium D3;
Calcide;
Calcium is an asset;
Calcium gluconate.

All of them are used to treat osteoporosis and prevent it.

Complivit calcium D3

Available in the form of chewable tablets with orange and mint flavors.

The drug contains the following substances:

Calcium 500 mg;
Vitamin D3 400 IU.

Refers to calcium-phosphate metabolic regulators. The medicine has a round, slightly rough shape with a white or slightly creamy color.

Restores calcium and phosphate metabolism, reduces bone and joint wasting and increases density bone bone. Complements the lack of calcium and vitamin D3 in the body.

Calcium is necessary for the functioning of the following systems:

Forms bone tissue;
Increases blood clotting;
Carries out the transmission of nerve impulses;
Supports the stability of the heart and blood vessels.

Indications:

Prevention and treatment of osteoporosis and its complications during menopause, taking hormones;
Replenishment of vitamin D3 and calcium deficiency.

Vitamin D3 helps:

Helps calcium to be well absorbed in the intestines;
Participates in the mineralization of bone tissue and teeth.

The drug Complivit calcium D3 is prescribed for the prevention and treatment of osteoporosis.

Price:

The price for 30 tablets is 249 rubles;
The cost of 100 tablets is 403 rubles.

The medicine is produced by Pharmstandard in the Russian Federation.

Calcide

The biologically active supplement is produced in the form of capsules and tablets. The medicine contains calcium eggshells, vitamins B, C, PP, E, A and D.

Eggshells contain large amounts of calcium and trace elements, which provide in the human body metabolic processes. The dietary supplement Calcide is produced by processing eggshells, which allows it to retain all its beneficial properties.

Additional vitamins are added to the drug. Therefore the remedy considered a source of natural calcium with a high content of vitamins.

Indications:

Replenishment of calcium and vitamin D3 deficiency;
Prevention and treatment of osteoporosis;
Increased immunity;
Strengthening the blood vessels of the heart;
Normalizes the functioning of the nervous and endocrine systems.

The cost for a package of 100 tablets in Russia is approximately 141 rubles. The medicine is produced in the Russian Federation by the company Comfort Complex.

Calcium-active

Available in tablet form and used biologically active additive to food. The medicine contains 50 mg of calcium and 50 IU of vitamin D3. Tablets are packaged in plastic containers 40 and 80 pieces each in each.

The drug contains a calcium metabolism regulator. Normalizes normal functioning structure and destruction of bone tissue. Calcium included medicine easily and quickly absorbed. His made from the amaranth plant, where calcium is present in large quantities. This allows you to replenish calcium deficiency in the body. Vitamin D3 and phosphorus improve the absorption of calcium, which enters the body with food. It is prescribed for various pathologies musculoskeletal system.

Indications:

As additional source calcium and vitamin D3;
Comprehensive treatment and prevention of osteoporosis;
Patients with diseases of the gums and teeth;
For teenagers to improve growth;
Frequent fractures and joint problems.

The price of tablets in Russia is 146 rubles for 80 tablets, which are packaged in plastic containers.

Calcium gluconate

The medicine is available in powder, tablets and ampoules with solution.

The product includes:

Calcium salt of gluconic acid;
White granular powder that dissolves quickly in hot water and slowly in cold.

Action:

Replenishes calcium deficiency in the body, which is involved in the transmission of nerve impulses, in the formation of bone tissue and teeth, and blood clotting;
Also prescribed to relieve intoxication;
Is an anti-inflammatory agent;
Antiallergic;
Hemostatic.

Belongs to the group of macro- and microelements. Its approximate cost in Russia is from 4 to 398 rubles depending on the release form and packaging.

Indications:

Allergy of unknown etiology;
Hepatitis;
Dermatological pathologies;
Bleeding;
Liver damage.

Dosage form:

Chewable tablets (orange, mint)

Compound:

Chewable tablets (mint) Active ingredients:calcium carbonate - 1250 mg (equivalent to elemental calcium - 500 mg), colecalciferol (vitamin D 3 ) - 5.0 mcg (200 IU) in the form of colecalciferol concentrate - 2.0 mg. Auxiliary components: sorbitol - 390 mg, mint granulate flavoring*** - 31.8 mg, povidone - 36.4 mg, magnesium stearate - 6.0 mg, aspartame - 1.00 mg.

*colecalciferol concentrate contains, including 10% excess: colecalciferol - 0.0055 mg, alpha-tocopherol - 0.022 mg, modified corn starch - 1.607 mg, sucrose - 0.385 mg, sodium ascorbate - 0.088 mg, interchain triglycerides - 0.066 mg, silicon dioxide - 0.026 mg.

**orange flavor granulate contains: isomalt -62.0 mg, orange flavor- 0.95 mg, mono- and diglycerides fatty acids- 0.0008 mg.

***mint flavor granulate contains: isomalt - 31.0 mg, mint flavor - 0.80 mg, mono- and diglycerides of fatty acids

0.0004 mg. Description:

Chewable tablets (orange)

White, round, biconvex tablets with orange flavor. May have small inclusions yellow and jagged edges.

Chewable tablets (mint)Round, biconvex, white tablets with mint flavor. May have small inclusions white to grayish in color and jagged edges. Pharmacotherapeutic group:Calcium-phosphorus metabolism regulator Pharmacodynamics:

A combined drug that regulates the exchange of calcium and phosphorus in the body (bones, teeth, nails, hair, muscles). Reduces resorption (resorption) and increases bone density, replenishing the lack of calcium and vitamin D 3 in the body, necessary for the mineralization of teeth. Calcium is involved in the regulation of nerve conduction, muscle contractions, hormone production and is a component of the blood coagulation system.

Adequate calcium intake is especially important during growth, pregnancy and lactation.

Vitamin D 3 increases calcium absorption in the intestine.

Use of calcium and vitamin D 3 prevents an increase in the production of parathyroid hormone (PTH), which is a stimulator of increased bone resorption (leaching of calcium from bones).

Pharmacokinetics:

Calcium

Absorption: Typically, the amount of calcium absorbed from the gastrointestinal tract is approximately 30% of dose taken.

Distribution and metabolism: 99 %, Calcium in the body is concentrated in the rigid structure of bones and teeth. The remaining 1% is found in intra- and extracellular fluids. About 50% of general content calcium in the blood is in a physiologically active ionized form, of which approximately 10 % in combination with citrate, phosphate or other anions, the remaining 40 % associated with proteins, primarily albumin.

Excretion: Calcium is excreted by the intestines, kidneys and sweat glands. Renal excretion depends on glomerular filtration and tubular reabsorption of calcium. VitaminD3

Absorption: Vitamin D 3 easily absorbed in the small intestine (about 80% of the dose taken).

Distribution and metabolism: its metabolites circulate in the blood bound to a specific globulin. Converted in the liver by hydroxylation to 25-hydroxycolecalciferol. It is then converted in the kidneys to the active form 1,25-hydroxycolecalciferol. 1,25-hydroxycolecalciferol is a metabolite responsible* for increasing calcium absorption. Unmetabolized Vitamin D 3 deposited in adipose and muscle tissue.

Elimination: Vitamin D 3 excreted by the intestines and kidneys.

Indications:

- Prevention and treatment of calcium and/or vitamin D deficiency 3 .

- Prevention and complex therapy of osteoporosis and its complications (bone fractures).

Contraindications:

- Hypercalcemia ( increased concentration calcium in the blood).

- Hypercalciuria (increased calcium in the urine).

- Nephrolithiasis.

- Hypervitaminosis D.

- Hypersensitivity to the components of the drug.

- Hypersensitivity to soy or peanuts.

- Severe renal failure.

- Active tuberculosis.

- Sarcoidosis.

Drug in dosage form tablets nIt is not used in children under 3 years of age. Calcium-Dz Nycomed contains, which is transformed in the body into. Therefore, the drug should not be taken by patients with phenylketonuria.

The drug contains isomalt and sucrose, so its use is not recommended for patients with hereditary fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase deficiency.

With caution:pregnancy, lactation, renal failure. Pregnancy and lactation:

Calcium-Dz Nycomed is used during pregnancy to replenish calcium and vitamin D deficiency in the body. Daily dose during pregnancy should not exceed 1500 mg of calcium and 600 IU of vitamin D 3 . Hypercalcemia due to overdose during pregnancy can have an adverse effect on the developing fetus. Calcium-Dz Nycomed is used during lactation.

Calcium and vitamin D 3 may pass into breast milk, so it is necessary to consider the intake of calcium and vitamin D from other sources in the mother and child.

Directions for use and dosage:

Calcium-Dz Nycomed is taken orally . The tablets can be chewed or dissolved and taken with meals.

Adults: in complex therapy of osteoporosis - 1 tablet 2-3 times a day, for the prevention of osteoporosis - 1 tablet 1 tablet 2 once a day.

For calcium and vitamin D deficiency: Adults and children over 12 years old - 1 tablet 2 times a day.

Children from 5 to 12 years: 1-2 tablets per day.

Children from 3 to 5 years old - dosage in accordance with doctor's recommendations.

Special groups of patients.

Patients with disordersFunctionsliver: No dose adjustment required. ,

PatientsWithviolationFunctionskidney: The drug Calcium-Dz Nycomed should not be used in case of severe renal failure.

Elderly patients: The dose is the same as for adults. A possible decrease in creatinine clearance should be taken into account.

Duration of treatment

When used for prevention and in complex therapy of osteoporosis, the duration of treatment is determined by the doctor individually.

When used to compensate for calcium and vitamin D deficiency 3 the average duration of treatment is at least 4-6 weeks. The number of repeat courses during the year is determined individually.

Side effects:

Frequency side effects the drug is considered as follows:

Very common: >1/10

Frequent: > 1/100,< 1/10

Uncommon: > 1/1000,< 1/100

Rare: > 1/10,000,< 1/1000

Very rare:< 1/10 000

Violations withsidesmetabolism and nutrition: Uncommon: hypercalcemia and hypercalciuria.

Gastrointestinal disorders: Rarely: constipation, flatulence, nausea, abdominal pain, diarrhea, dyspepsia.

Violations withsides of the skin and subcutaneousfiber: Very rare: itching, rash, urticaria.

Overdose:

Symptoms of overdose (hypercalcemia): anorexia, thirst, polyuria, muscle weakness, nausea, vomiting, constipation, abdominal pain, fatigue, bone pain, mental disorders, nephrocalcinosis, urolithiasis and, in severe cases, cardiac arrhythmias. With long-term use of excessive doses (over 2500 mg of calcium) - kidney damage, soft tissue calcification.

If signs of overdose are detected, you must stop taking calcium and vitamin D as well as thiazide diuretics and cardiac glycosides, and consult a doctor.

Treatment: gastric lavage, replacement of fluid loss, use of loop diuretics (for example, furosemide), glucocorticosteroids, calcitonin, bisphosphonates.

It is necessary to monitor the content of electrolytes in the blood plasma, renal function and diuresis.

In severe cases, it is necessary to measure central venous pressure (CVP) and monitor the electrocardiogram (ECG). Interaction:

- Hypercalcemia may potentiate the toxic effects of cardiac glycosides when used concomitantly with. calcium and vitamin D supplements. Monitoring of ECG and serum calcium levels is necessary.

- Calcium preparations can reduce the absorption of tetracyclines from the gastrointestinal tract. Therefore, tetracycline preparations should be taken at least 2 hours before or 4-6 hours after taking Calcium-Dz Nycomed.

- To prevent decreased absorption of bisphosphonate drugs, it is recommended to take them at least an hour before taking Calcium-Dz Nycomed.

- Glucocorticosteroids reduce calcium absorption, so treatment with glucocorticosteroids may require increasing the dose of Calcium-Dz Nycomed:

- With the simultaneous use of thiazide diuretics, the risk of hypercalcemia increases, since they increase tubular reabsorption of calcium. When using thiazide diuretics simultaneously, the calcium level in the blood serum should be regularly monitored.

- Calcium reduces the effectiveness of levothyroxine by reducing its absorption. The period of time between taking levothyroxine and Calcium-Dz Nycomed should be at least 4 hours.

- The absorption of quinolone antibiotics is reduced when used simultaneously with calcium supplements. Therefore, quinolone antibiotics should be taken 2 hours before or after 6 hours after taking Calcium-Dz Nycomed.

- Taking food products containing oxalates (sorrel, rhubarb, spinach) and phytin (cereals) reduces the absorption of calcium, so you should not take Calcium - Dz

Special instructions:

During long-term therapy, calcium and calcium levels should be monitored.serum creatinine. Monitoring is especially important in elderly patients during concomitant treatment with cardiac glycosides and diuretics (see section"Interaction with others medicines And food products") and in patients with an increased tendency to form kidney stones. In - cases of hypercalcemia or signs of renal impairment, the dose should be reduced orstop treatment.

Vitamin D should be used with caution in patients with renal impairmentinsufficiency. In this case, it is necessary to monitor the calcium and phosphate levels in the blood serum. The risk of soft tissue calcification must also be considered.

- To avoid overdose, it is necessary to take into account. additionalvitamin intake D from other sources.- Calcium and - vitamin D 3 , should be used with caution

immobilized patients with osteoporosis due to the risk of hypercalcemia.

- Concomitant use with tetracycline or quinolone antibiotics is usually not recommended or should be done with caution (see section"Interaction with other drugs and food products").

Impact on the ability to drive vehicles. Wed and fur.:

The drug Calcium-Dz Nycomed does not affect the ability to drive vehicles or work with technically complex mechanisms.

Release form/dosage:Chewable tablets, 500 mg + 200 ME. Package: 20, 50 or 100 tablets in a bottle made of high-density polyethylene, sealed with a screw cap, iodine of which is a ring for tearing off the sealing gasket, ensuring control of the first opening.

1 bottle along with instructions for use is placed in a cardboard pack.

Chewable tablets (mint), 500 mg + 200 ME.

30 or 100 tablets in a bottle made of high-density polyethylene, sealed with a screw cap, under which there is a ring for tearing off the sealing gasket, ensuring first opening control.

1 bottle along with instructions for use is placed in a cardboard pack.

Storage conditions:Keep the bottle tightly closed at a temperature not exceeding 25 °C. Keep out of the reach of children! Best before date:

3 years

Do not use after expiration date.

Conditions for dispensing from pharmacies: Over the counter Registration number: P N013478/01 Registration date: 16.09.2011 Owner of the Registration Certificate:Takeda Nycomed AS Norway Manufacturer: Representative office: Takeda Pharmaceuticals LLC Information update date: 24.02.2015 Illustrated instructions

The popular medicine “Calcium D3 Nycomed” is based on substances such as calcium and vitamin D3. Main pharmacological action This medication is that it prevents excessive synthesis of parathyroid hormone, which improves bone resorption. Both active substances of the drug help regulate phosphorus-calcium metabolism in the patient’s body. Good reviews This medicine has earned its value, among other things, for its relatively low cost. However, many people would probably still like to know whether there is an analogue of “Calcium D3 Nycomed” that is cheaper in cost. Of course, there are such drugs on the modern pharmacological market.

Why do they take it?

Vitamins "Nycomed calcium d3 Nycomed"drink primarily for this purpose, to:

replenish calcium deficiency in bones;

improve blood clotting;

restore bone tissue;

Mineralize teeth and bones;

regulate calcium absorption in the gastrointestinal tract.

This medicine is supplied to the market in the form of chewable round tablets in jars. Its dosage depends on the age of the person and the type of disease. Typically, patients are prescribed 2-3 tablets per day. The course of treatment most often lasts 1-2 months. When choosing a cheaper analogue of Calcium D3 Nycomed, you should, of course, pay attention to its instructions for use. Some drugs in this group are prescribed in smaller dosages, others in larger dosages.

“Calcium D3 Nycomed” costs about 200-250 rubles. for 30 tablets.

Contraindications

Of course, “Calcium D3 Nycomed” and cheaper analogues of this medicine may not be prescribed to patients by doctors in all cases. Contraindications to the use of the original medicine are:

renal failure;

increased calcium levels in the blood;

acute form of tuberculosis;

sarcoidosis;

isomaltose-sugar deficiency;

phenylketonuria.

Of course, you should not take this medicine if you are intolerant to any of its components.

The best cheap analogues

Judging by the reviews, this drug is quite effective. But since it is quite expensive, of course, many consumers are interested in what to replace Calcium D3 Nycomed with. Cheap analogue instead of this drug, for example, you can use the following:

"Complivit calcium D3."

"Calcid".

"Calcium active".

“Take calcium D3.”

"Calcemin".

Also on sale is an analogue of “Calcium D3 Nycomed”, which is cheaper in price and called “Mountain Calcium with D3 and Shilajit”.

Analogue - “Complivit”

Like D3 Nycomed, this drug is extremely popular on the market. It is also intended to regulate the phosphorus-calcium balance in the body. The difference between these two drugs is that Complivit D3 additionally contains citric acid. It is believed that this component promotes better absorption of calcium.

Complivit calcium D3 is much cheaper than D3 Nycomed. For 30 tablets of this medicine, the pharmacy usually asks for 100-120 rubles. In this case, the daily dosage of this drug is most often 1-2 tablets.

Reviews

This medicine is most often used instead of Calcium D3 Nycomed. What analogues for this medicine exist that are high-quality and inexpensive? In answer to this question, in most cases this particular drug is called. Consumers have generally good opinions about this dietary supplement. Among the undoubted advantages of this medicine, patients say, first of all, that it simply perfectly replenishes the lack of calcium in the body. Also, many patients note the fact that this medication simply perfectly promotes bone healing after fractures. There are different reviews regarding the taste of Complivit calcium D3 tablets. Many patients find that this medicine is very easy to take. Others believe that the taste of these tablets is not particularly pleasant.

Some patients consider the only disadvantage of this drug to be that sometimes people experience it individual intolerance. It is better not to take Complivit calcium D3 for such patients. This can negatively affect the health of their liver.

Medicine "Calcid": composition and cost

This analogue is also often prescribed by doctors instead of Calcium D3 Nycomed. The main advantage of this drug is its low cost. This medicine replenishes calcium in the body quite well. Vitamin D3, which improves the absorption of this microelement, is present in the preparation, despite its absence in the name. In fact, “Calcid” is just a cheap domestic generic of the drug “D3 Nycomed”. The drug “Calcid” costs about 150 rubles. for 100 tab. It is prescribed in the amount of approximately 3 tablets per day.

Consumer opinion about "Kaltsid"

This drug is chosen by many consumers who are looking for cheaper analogues for the drug “Calcium D3 Nycomed”. This medication has received simply excellent reviews from patients. Most patients note the fact that it helps no worse than the advertised “Calcium D3 Nycomed”. Of course this medicine deserves it great reviews and for its very low cost.

Consumers consider the only disadvantage of Calcid to be that defective (too hard) tablets are sometimes found on sale.

"Calcium active"

Many drugs in this group, including, for example, Calcid, are not recommended for women expecting a child. Therefore, many consumers are interested in whether there are cheaper analogues on the market for Calcium D3 Nycomed for pregnant women. Fortunately, such medicines exist in pharmacies today. For example, a pleasant exception in this case is “Calcium Active”. This drug is called the best in the group for pregnant women.

In addition to the main substance itself, this medication contains a complexone substance, which stabilizes the “building-destruction” of human bone tissue. This medicine is made on the basis not of ordinary, but vegetable calcium, obtained from the amaranth plant. In this form, this microelement is much better absorbed by the human body.

This analogue of “Calcium D3 Nycomed” is cheaper than the latter. The price for it in pharmacies is about 80 rubles. for 40 tab.

Reviews about the medication

Many consumers also praise this dietary supplement. However, some people who have taken it believe that it is somewhat inferior in effectiveness to the drug “Calcium D3 Nycomed”. This medicine is cheaper than some other analogues. But it is recommended to take it not 2-3 tablets a day, but 4. The effect, according to many consumers, when using this medicine is noticeable later than when using Calcium D3 Nycomed.

Among the disadvantages of this medicine, among other things, some consumers include the fact that it can negatively affect kidney function.

"Beresh calcium D3"

This drug can also be classified as a fairly effective cheap substitute for Nycomed D3. It costs about the same - around 200-250 rubles. for 30 tablets. This dietary supplement is produced in Hungary. Its indications and contraindications are the same as those of the drug “Calcium D3 Nycomed”.