Klion d tablets analogues. Special instructions for the use of Klion D. Instructions for use

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Klion D is a local medicinal combination drug, intended for treatment infectious diseases female genital organs. Klion D tablets are inserted into the vagina and have antiprotozoal (destroys protozoa, for example, Trichomonas, etc.), antibacterial and antifungal effect. Due to the specifics clinical action used in the treatment of vaginal trichomoniasis and candidiasis.

Dosages, release forms and composition of Klion D

Currently, the drug Klion D is available in only one dosage form – vaginal tablets . Klion D is not produced in the form of suppositories. The correct name of the drug is Klion D, however, the following options can be used in everyday life - “Klion D tablets” and “Klion D 100”. The drug is manufactured by the Hungarian pharmaceutical corporation GEDEON RICHTER, Plc. Klion D goes on sale in packs of 10 tablets.

Klion D tablets are colored white or almost white, have an oval, biconvex shape and a pointed end. On one side of the tablets there is an embossed "100" engraving. Tablet size 14 x 24 mm.

Each Klion D tablet contains 100 mg of active ingredients metronidazole and 100 mg miconazole. Metronidazole has antibacterial and antiprotozoal effects, and miconazole has antifungal effects.

As auxiliary components, Klion D tablets contain the following chemical compounds:

sodium lauryl sulfate;
Colloidal silicon dioxide;
Magnesium stearate;
Povidone;
Sodium bicarbonate;
Tartaric acid;
Sodium carboxymethyl starch;
Crospovidone;
Hypromellose;
Lactose monohydrate.

Absorption, distribution and excretion of Klion D

Klion D tablets are used for intravaginal administration, therefore they provide local action, destroying pathogenic microorganisms directly into a woman's vagina. However, after inserting the tablet into the vagina, metronidazole contained in it as one of the active substances is able to be absorbed into the vagina. systemic blood flow. In this case, the maximum concentration of metronidazole in the blood is achieved 6 to 12 hours after inserting the Klion D tablet into the vagina. Moreover, the concentration in the blood is 50% of that which is recorded when taking 100 mg of metronidazole orally. Due to its good absorption into the bloodstream, metronidazole from Klion D tablets used intravaginally penetrates into breast milk, through the placenta to the fetus, and into the structures of the spinal cord and brain.

60–80% of the metronidazole that enters the bloodstream is excreted by the kidneys in the form of chemical metabolites that color the urine reddish or brown. The remaining 20–40% of metronidazole absorbed into the blood is excreted in feces through the intestines.

Miconazole, unlike metronidazole, is practically not absorbed into the systemic circulation. Therefore, miconazole when administered intravaginally is not detected either in the blood or in the urine. 8 hours after the administration of the Klion D tablet, 90% of miconazole is still present in the woman’s vagina, having a powerful destructive effect on Candida fungi.

Klion D - therapeutic effects and scope of application

Klion D has antibacterial, antifungal and antiprotozoal effects, which are provided by two active components - metronidazole and miconazole.

Metronidazole provides a detrimental effect on protozoa (antiprotozoal action) and bacterial (antibacterial action) microorganisms. And miconazole provides an antifungal effect.

Metronidazole suppresses the processes of reduction of nitro groups inside the cells of protozoa and bacteria. As a result, the unreduced nitro group suppresses microbial DNA synthesis by combining with certain sections of nucleic acids. The absence of DNA synthesis entails the inability of microorganisms to reproduce and, accordingly, their death.

Miconazole inhibits the synthesis of one of the main lipid components of the fungal membrane - ergosterol. Due to the lack of ergosterol, the fungal cell membrane becomes loose and excessively permeable to water and salts, which enter the cell matrix in excess quantities from the surrounding space. Excess water and salts provoke a disruption of the normal balance inside cells, which leads to the death of fungi. Miconazole has a selective effect, destroying only fungi, and without disturbing the composition of the normal microflora and acidity of the vagina.

Klion D is active against the following pathogenic microorganisms:

Fungi of the genus Candida (mainly Candida albicans);
Trichomonas vaginalis (Trichomonas vaginalis);
Vaginal amoeba (Entamoeba histolytica);
Gardnerella vaginalis;
Guardia (Giardia lamblia);
Bacteroides – Bacteroides spp. (B. fragilis, B. ovatus, B. distasonis, B. thetaiotaomicron, B. vulgatus);
Fusobacterium (Fusobacterium spp.);
Veillonella spp.;
Prevotella – Prevotella spp. (Prevotella bivia, Prevotella buccae, Prevotella disiens);
Clostridia (Clostridium spp.);
Eubacteria (Eubacterium spp.;
Peptococcus (Peptococcus spp.);
Peptostreptococcus spp.

Due to the peculiarities of the clinical spectrum of action of Klion D tablets, they are used mainly for the treatment of trichomoniasis, candidiasis and other infectious diseases. inflammatory diseases vagina, provoked by opportunistic and pathogenic microflora (for example, gardnerellosis, clostridiasis, amoebiasis).

Indications for use

The indication for the use of Klion D tablets is the treatment of inflammatory diseases of the vagina (vulvitis) caused by Trichomonas spp. or Candida spp. Accordingly, the indications for the use of Klion D are trichomoniasis or candidiasis, or a combination of both infections.

Klion D - instructions for use

Klion D tablets are inserted deep into the vagina using a finger. Before administering the drug, you should thoroughly wash your hands and wash the external genitalia. warm water with soap. Immediately before inserting the Klion D tablet into the vagina, it should be moistened with clean, warm water.

Klion D for trichomoniasis

Klion D for trichomoniasis (trichomonas vulvitis) must be injected deep into the vagina, one tablet moistened with water once a day. It is recommended to administer the tablet in the evening, just before going to bed. The duration of the course of treatment is 10 days. For maximum effectiveness of treatment of trichomonas vulvitis (colpitis), simultaneously with vaginal administration of Klion D, it is necessary to take one tablet of Klion or Metronidazole orally twice a day (morning and evening) during or after meals, also for 10 days. Metronidazole tablets must be swallowed whole without chewing. If a 10-day course of treatment with Klion D does not cure trichomoniasis, then it can be extended for another 10 days.

Treatment courses for trichomoniasis using Klion D can be repeated as needed.

Klion D for thrush

For thrush, Klion D is injected deep into the vagina once a day for 10 days. Every day you need to administer one tablet, pre-moistened with water. Optimal time The best time to administer the Klion D tablet is in the evening, right before going to bed.

If necessary, the course of treatment of candidiasis with Klion D can be repeated as many times as needed. However, if Klion D is repeatedly ineffective, it is recommended to test the vaginal discharge for sensitivity to antimycotics, which will help determine which antifungal drug the subspecies of Candida fungus that caused candidiasis in this particular case is sensitive to.

Klion D during pregnancy

In the first trimester of pregnancy (up to the 12th week of gestation inclusive), Klion D is contraindicated for use, since metronidazole, which is part of it, can be absorbed into the systemic bloodstream and penetrate through the placenta to the fetus. In the second and third trimesters of pregnancy (from the 13th to the 40th week of gestation), Klion D can be used only if the expected benefit outweighs the potential risks to the fetus.

According to experimental studies of metronidazole conducted on pregnant rats and mice, no negative influence the drug to the fetus even when a five-fold dose is administered to females. With intraperitoneal (intraperitoneal) administration of a human dose of metroniadazole to rats, an increase in toxic effects on the fetus was recorded. However, when the same dose of metronidazole was administered in tablet form, no toxic effects on the fetus were detected. For obvious ethical reasons, similar studies have not been conducted on pregnant women. However, according to studies carried out on mathematical models based on the results of animal experiments, no increase in negative effects on the fetus was detected when metronidazole was used at any stage of pregnancy, including in the first trimester. This is why metronidazole cannot be used during pregnancy as widely as desired. Klion D tablets can be used when all possible risks and concluded that the benefits of the drug to a pregnant woman would be greater than the hypothetical risks to the fetus.

Since metronidazole from vaginal tablets Klion D penetrates into the systemic bloodstream, and from there into breast milk, then you should not use the drug simultaneously with breastfeeding. It is better to stop breastfeeding while using Klion D tablets and resume it after completing the course of therapy. You can resume breastfeeding 1 – 2 days after use last pill Kliona D.

Klion D during menstruation

Klion D is not recommended for use during menstruation, since in the presence of blood the effectiveness active ingredients vaginal tablets is significantly reduced. In addition, part of the dissolved Klion D tablet is washed out of the vagina along with menstrual blood, which reduces the concentration of active substances and, therefore, makes it ineffective. Because of this, if a woman is menstruating, then the start of treatment with Klion D tablets should be postponed until the end of monthly bleeding. However, if menstruation began unexpectedly while using Klion D tablets, then you can continue the current course of therapy, keeping in mind the possibility of relatively low effectiveness of the treatment provided.

Special instructions for the use of Klion D

During the entire course of treatment, you should abstain from sexual intercourse with any partners. If complete abstinence from sexual intercourse during treatment with Klion D is impossible, then you should definitely use a condom.

During treatment with Klion D, it is impossible to test for treponemes, since metronidazole provokes false positive results Nelson test (TPI test).

When using Klion D, there may be a decrease total number leukocytes are below normal (leukopenia), therefore, during the entire course of treatment it is recommended to regularly take a general blood test.

Klion D can provoke various side effects from the central nervous system Therefore, during treatment with this drug, it is recommended to avoid any activity that requires increased concentration and attention. high speed psychomotor reactions, for example, driving a car, conveyor belt, etc.

Overdose of Klion D

An overdose of Klion D with proper intravaginal use is impossible. However, if Klion D tablets are used in combination with Metronidazole for oral administration, severe side effects and overdose may develop.

Symptoms of overdose are nausea, vomiting, abdominal pain, diarrhea, itchy skin, metallic taste in the mouth, impaired coordination of movements (ataxia), dizziness, convulsions, decreased total number leukocytes (leukopenia), red urine, paresthesia (feeling of “pins and needles”, etc.).

If symptoms of a metronidazole overdose are detected, or a person accidentally takes Klion D tablets orally, then they should immediately rinse the stomach, drink a sorbent (activated carbon, Enterosgel, Polysorb, Polyphepan, etc.) and perform hemodialysis. Otherwise, symptomatic treatment must be used.

Interaction with other drugs

Klion D can be used in combination with antibiotics and sulfonamide drugs administered intravenously, intramuscularly or orally.

Klion D should not be used together with Disulfiram, as this may cause confusion. It is also not recommended to use Klion D in combination with a muscle relaxant (a drug that relaxes muscles) vecuronium bromide.

Klion D enhances the effect indirect anticoagulants(for example, Warfarin, Dicumarin, Thrombostop, etc.) as a result of which, with the combined use of these drugs, a pronounced increase in prothrombin time is possible, which requires correction (reduction) of the dose of the anticoagulant.

Drugs that can enhance the processes of microsomal oxidation in the liver (for example, Phenobarbital, Phenytoin, alcohol, etc.) accelerate the elimination of metronidazole from the body, which reduces its effectiveness. Therefore, the combined use of Klion D with drugs that enhance microsomal oxidation in the liver is not recommended.

Cimetidine reduces the elimination rate of metronidazole, which may increase the severity of side effects.

Klion D increases the concentration of lithium in the blood plasma, therefore, during treatment with metronidazole, it is necessary to reduce the dosage of lithium preparations or stop taking them.

Vaginal tablets Klion D: instructions for use - video

Features of treatment with Klion D tablets

During the use of Klion D vaginal tablets, various local reactions may appear, such as discharge from the genitals, a feeling of discomfort, burning or itching.

Discharge after Klion D

Discharge after Klion D can be of various types. However, most often the discharge is semi-liquid or liquid, mucous, uncolored (transparent) or white, with a slight specific odor. In some cases, the discharge may be thick, with white flakes and a slight odor. In some women with severe inflammatory process after Klion D, orange, brownish or red discharge may appear, the color of which is due to the admixture of blood. Such discharge is not a reason to stop treatment, since it is associated with injury to the vessels located in the inflamed vaginal mucosa. If there is discharge mixed with blood, an urgent visit to a gynecologist is not required; you can go at the scheduled time. After completion of treatment with Klion D, discharge may be observed for 1 to 2 weeks.

Klion D – burning sensation during use

Klion D tablets can provoke locally irritating reactions, such as a burning sensation, itching or pain in the vagina. Therefore, the burning sensation caused by the use of Klion D is normal reaction woman's body on the effect of the drug. A burning sensation may appear on any day of treatment, for example, on the first or fifth, etc. Availability of this subjective feeling is not an indication for discontinuation of the drug and cessation of treatment.

Klion D and alcohol

Klion D and alcohol are incompatible. This means that during treatment with Klion D you should refrain from taking alcoholic drinks. Drinking alcohol during treatment with Klion D tablets can provoke unwanted reactions, such as cramping abdominal pain, nausea, vomiting, headache and flushing (redness) of the skin. The above reactions take place after dose taken alcohol will be completely neutralized in the liver.

Klion D - side effects

When using vaginal tablets Klion D, side effects are most often observed in the form of various local reactions, such as:

Burning sensation in the vagina;
Pain in the vagina;
Severe itching of the genitals;
Irritation of the vaginal mucosa;
Vaginal discharge is thick or thin, white or transparent, mucous in nature and has a slight odor;
A burning sensation or irritation of the penis in the sexual partner after sexual contact, produced against the background of the use of Klion D tablets.

Systemic side effects when using Klion D tablets develop relatively rarely, but their occurrence is quite possible. To system side effects from the outside various organs and systems include the following:
1. From the digestive tract:

Nausea;
Change in taste;
Metallic taste in the mouth;
Coated tongue;

From the liver:

Stagnation of bile;
Increased activity of transaminases (AST, ALT).

Klion D - contraindications for use

Klion D is contraindicated for use if a woman has the following conditions or diseases:

Leukopenia (decrease in the total number of white blood cells) at the present time or in the past;
Organic diseases of the central nervous system, for example, epilepsy, strokes, etc.;
I trimester of pregnancy (up to the 12th week inclusive);
Breastfeeding period;
Age under 12 years;
Increased sensitivity or allergic reactions for any substances contained in the drug;
Hypersensitivity or allergic reactions to other drugs with azole structure (for example, Clotrimazole, Imidazole, Ornidazole, etc.).

relative contraindications

Klion D - analogues

pharmaceutical market

medicines

different composition

Synonyms of Klion D are the following drugs:

Neo-Penotran and Neo-Penotran forte vaginal suppositories;
Metromicon-Neo vaginal suppositories.

The following drugs are analogues of Klion D:

Vagisept vaginal suppositories;
Vagiferon vaginal suppositories;
Gainomax vaginal suppositories;
Ginalgin vaginal tablets;
Clomegel vaginal gel.

antibacterial effect

For treatment gynecological diseases specialists prescribe vaginal suppositories. Among the most effective are Klion-D suppositories with miconazole.

International nonproprietary name

International generic name candles Klion-D - Klion-D.

ATX and registration number

The ATC code and registration number of the drug is G01AF20. This tool belongs to group G01A (imidazole derivatives).

Pharmacotherapeutic group

Combined antimicrobial agent. It is also called an antiprotozoal and antifungal drug.

Mechanism of action

The composition includes components that have a complex effect on the vaginal microflora. They inhibit pathogenic microorganisms, making them non-viable. After entering the vagina, the medicine is absorbed into the mucous membranes.

Metronidazole does not start working immediately. Its concentration in the blood increases gradually and reaches its maximum only after 9 hours. After a few days, no traces of the drug remain in the body. 60-80% of the component is excreted by the kidneys, turning the urine reddish. The remaining amount of metronidazole is excreted in the feces.

Miconazole - antifungal agent, destroying dermatophytes and yeast fungi. It does not disturb the pH and does not suppress healthy microflora in the vagina. Lipid synthesis stops in the membrane of fungal organisms. Miconazole is not detectable in urine. 90% of it is excreted from the body. The maximum concentration in the blood can be achieved 8 hours after administration of the drug. IN biological fluids not detected if suppositories are administered vaginally. At the same time, the drug destroys fungi of the genus Candida, affecting them locally.

Composition of Klion-D candles

Klion D suppositories contain 0.1 g of active ingredients - metronidazole and miconazole. It also contains auxiliary components. TO excipients include lactose, silicon dioxide, povidone, starch, tartaric acid.

Also available in the form of tablets and solution for injection.

What do Klion-D suppositories treat?

The indication for the use of Klion-D suppositories is the development of trichomoniasis or candidiasis. These diseases are caused by the microorganisms Trichomonas spp. or Candida spp. Fungal infection provokes such a common disease as thrush.

The drug can also be recommended for other infectious and inflammatory diseases of the vagina, if they are provoked by opportunistic or pathogenic microflora. prescribed for the development of gardnerellosis, clostridiasis, and amoebiasis.

Contraindications

The drug may not be used in all cases. The most important contraindications are the first trimester of pregnancy, lactation,. IN medicinal purposes at liver failure This drug should not be used.

The drug is prohibited for the treatment of children under 12 years of age. Vaginal tablets are not recommended for use in cases of epilepsy and various lesions of the nervous system. With leukopenia, the content of leukocytes in the blood is greatly reduced, so drugs with metronidazole cannot be used. This will only make the problem worse. It's better to find a safer replacement.

During development diabetes mellitus It is better not to use the drug. It is also contraindicated individual intolerance. If a person is allergic to active ingredients, you should consult your doctor. When an allergy occurs suddenly, further treatment should be avoided.

How to use Klion-D suppositories

For thrush

For thrush, Klion-D suppositories must be administered into the vagina once a day, 1 suppository. The course of treatment is 10 days. There are cases when no improvement is observed during treatment. In this situation, a second course may be required, but it can be started only 10 days after the end of the first stage of treatment.

Can be passed additional tests, in order to determine the pathogen more accurately and determine how sensitive it is to metronidazole, adjust the therapy.

For trichomoniasis

If trichomoniasis develops, 1 suppository Klion-D is prescribed once a day. It is better to carry out treatment at the same time. The duration of the course is from 10 to 14 days. The attending physician will draw up a treatment plan in more detail. For this disease, it is often prescribed additional dose tablets containing metronidazole.

If trichomoniasis develops, 1 suppository Klion-D is prescribed once a day. It is better to carry out treatment at the same time. The duration of the course is from 10 to 14 days.

Trichomoniasis is a disease that is almost always transmitted to a sexual partner, so both women and men need treatment. The specialist will select the right drug. At the end of treatment, both partners must undergo tests to monitor the effectiveness of the therapy.

How to bet

For treatment to be effective, suppositories must be placed correctly. It is best to carry out this procedure at night. After this, it is advisable to take a horizontal position, lie on your back, placing a small pillow under your buttocks. This will help avoid leakage of the drug from the vagina and increase the therapeutic effect.

Before the procedure, you need to wash your hands with soap. The genitals should be washed thoroughly. It is advisable to moisten the suppository with warm water immediately before insertion into the vagina. The instructions for use provide detailed recommendations.

Before starting the procedure, you need to wash your hands with soap.

Special instructions

During treatment you should avoid sexual intercourse. Some experts are not too categorical on this issue and believe that intimate life acceptable, but with the use of a condom.

Is it possible to take Klion-D during menstruation?

Klion-D cannot be used during menstruation for several reasons. The presence of blood in the genital tract leads to changes acid-base balance and the drug turns out to be ineffective. WITH menstrual flow Most of the drug leaks out. Such treatment may not lead to the expected effect.

Experts advise planning treatment after the end of menstruation or before it begins. If your period comes during the period of therapy, you need to discuss this issue individually with a gynecologist. Sometimes doctors advise replacing Klion-D with a drug that must be taken orally.

During pregnancy and lactation

In the first trimester of pregnancy, the use of Klion-D is strictly prohibited. In the second and third trimesters, treatment with the drug is possible, but only in case of urgent need and after agreement with the gynecologist. The components tend to penetrate the placental barrier and can affect the development of the fetus.

The drug should not be used during breastfeeding. Active substance passes into breast milk. If treatment is necessary and only with this remedy, breastfeeding should be stopped.

In childhood

Klion-D cannot be used in childhood. The drug is suitable for the treatment of teenage girls, but under the condition strict adherence doctor's recommendations.

In old age

In old age, suppositories with this type of effect can only be used after consultation with a gynecologist. It is necessary to consider whether the woman has chronic diseases.

For kidney and liver diseases

In case of liver failure, the use of drugs with metronidazole is strictly prohibited. Diseases of low severity do not exclude the possibility of treatment with these suppositories, but the decision on the advisability of such therapy must be made by a doctor.

Side effects

When using the drug, side effects may be present. The most common are itching and discomfort in the vagina. Some patients do not consider this to be the body’s reaction to the drug, since similar symptoms were present before the start of therapy.

A woman may experience diarrhea and vomiting during treatment. appears in the mouth metallic taste. Nausea and headache may be observed on the very first day of taking the drug.

In some cases, you have to deal with skin rashes and allergies. If swelling of the face appears, it is better to stop treatment with this remedy and consult a doctor. Urine turns reddish-brown. This sign classified as a side effect, but this is considered normal and does not cause the woman any discomfort.

During treatment, clinical blood test parameters may change. There is no point in conducting diagnostics. During this period, vaginal discharge increases.

Effect on driving

The drug affects the nervous system. The speed of reactions slows down somewhat. Strict contraindications There is no need to drive any vehicles during the treatment period, but experts advise caution. If possible, it is better to refrain from driving when using the medication during the daytime.

If possible, it is better to refrain from driving when using the medication during the daytime.

Overdose of Klion-D

Overdose candles Klion-D with vaginal administration is unlikely. It can only occur during a combination of treatment with suppositories and oral medications with metronidazole. A woman may begin to feel sick, it can be felt severe weakness. In case of an overdose, the content of leukocytes in the blood decreases sharply.

Drug interactions

The medication should not be used simultaneously with psychotropic drugs. The likelihood of developing severe depression increases dramatically.

Alcohol compatibility

Klion-D is not compatible with alcohol. greatly reduces the effectiveness of treatment. When drinking alcohol during therapy, a woman should remember that it is unlikely to achieve results.

rapid achievement of maximum concentration in the body and, as a result, the onset of a rapid therapeutic effect;
availability of several forms of release: solution for intravenous administration, pills;
low price compared to analogues.

Flaws:

low bioavailability of the drug compared to analogues.

Klion solution for infusion 5 mg/ml, 1 pc.
126.00 rub.

Klion tablets 250 mg, 20 pcs.
65.80 rub.

* The maximum permissible retail price is indicated medicines calculated in accordance with Decree of the Government of the Russian Federation No. 865 of October 29, 2010 (For those medicines that are on the list)

Instructions for use:

Tablets are prescribed orally during or immediately after meals, without chewing and with a sufficient amount of cool, clean water.

For trichomoniasis the drug is prescribed:

children from 2 to 5 years, 250 mg per day, children from 5 to 10 years, 250–375 mg per day, over 10 years, 500 mg per day orally, with the daily dose divided into 2 doses. The course of treatment is 10 days;

for adults, the drug is prescribed 250 mg 2 times a day for 10 days or 400 mg 2 times a day for 5 – 8 days;

Women should additionally be prescribed metronidazole in the form vaginal suppositories or tablets.

If necessary, the course of treatment is repeated after 3–4 weeks.

The course of treatment is 10 days.

For giardiasis the drug is prescribed:

children under 1 year, 125 mg per day, children from 2 to 4 years, 250 mg per day, children from 5 to 8 years, 375 mg per day, over 8 years, 500 mg per day, daily dose divided into 2 doses. The course of treatment is 5 days. After completion of treatment, a control laboratory test is performed 2–3 months later.

For adults, the drug is prescribed 500 mg 2 times a day. The course of treatment is 5–7 days.

For giardiasis, the drug is prescribed at a dose of 15 mg per 1 kg of body weight per day, the dose is divided into 3 doses over 5 days.

For amoebiasis, the drug is prescribed:

children (depending on age) - 1/4 - 1/2 adult dose.

adults: 1–1.5 g per day, divided into 2–3 doses, for 5–10 days.

For eradication Helicobacter pylori the drug is prescribed 500 mg 3 times a day for 7 days (as part of combination therapy).

At anaerobic infection the drug is prescribed:

children under 12 years old - 7.5 mg per 1 kg of body weight 3 times a day.

adults 400-500 mg 3-4 times a day.

The course of treatment is 7 – 10 days.

For chronic alcoholism, the drug is prescribed at 500 mg per day. The course of treatment should not exceed 6 months.

For prevention infectious complications the drug is prescribed at 750–1500 mg per day in 3 divided doses 3–4 days before surgery or a single dose of 1000 mg on the first day after surgery. 1–2 days after surgery, the drug is taken at a dose of 750 mg for another 7 days.

The injection solution is administered intravenously. For children under 12 years of age, the dose is calculated based on body weight - 7.5 mg of the drug per 1 kg. For adults and children over 12 years of age, the drug is administered at an initial dose of 500–1000 mg, then 500 mg every 8 hours at a rate of 5 ml per minute.

The course of treatment is individual and selected by the attending physician.

The drug is prohibited for use during the first trimester of pregnancy (up to 12 - 13 weeks) and during lactation.

Children are allowed from 2 years of age.

Comparison table

Drug name	Bioavailability, %	Bioavailability, mg/l	Time to reach maximum concentration, h	Half-life, h




Klion

Description and instructions: to " KLION D, tbl vagina. 100mg No. 10"

Indications for use drug Klion-D 100

Trichomonas, candidal and nonspecific vaginitis (local treatment).

Release form of the drug Klion-D 100:

vaginal tablets; contour packaging without cells 10, cardboard pack 1;

vaginal tablets 100 mg + 100 mg; strip 10, cardboard pack 1;

vaginal tablets 100 mg + 100 mg; strip 10, box 100;

Compound.

Vaginal tablets 1 table.

metronidazole100 mg

miconazole nitrate100 mg

excipients: sodium lauryl sulfate; colloidal silicon dioxide; magnesium stearate; povidone; sodium bicarbonate; tartaric acid; sodium carboxymethyl starch (type A); crospovidone; hypromelose; lactose monohydrate

in contour-free packaging 10 pcs.; in a cardboard pack 1 package.

Pharmacodynamics of the drug Klion-D 100.

The mechanism of action of metronidazole is the biochemical reduction of the 5-nitro group by intracellular transport proteins anaerobic microorganisms and protozoa. The reduced 5-nitro group interacts with the DNA of the cell of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of microorganisms.

Metronidazole is a broad-spectrum antimicrobial and antiprotozoal agent. Active against Trichomonas vaginalis, Giardia intestinalis, Entamoeba histolytica, Lamblia intestinalis as well as against obligate anaerobes (spore- and non-spore-forming) - Bacteroides spp. (Bacteroides fragilis, Bacteroides ovatus, Bacteroides distasonis, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Clostridium spp., Peptostreptococcus spp., sensitive strains of Eubacterium. Not sensitive to metronidazole aerobic microorganisms and facultative anaerobes.

Miconazole has antifungal activity against common dermatophytes, yeasts and various other fungi and antibacterial activity against certain gram-positive bacteria.

Miconazole inhibits the biosynthesis of ergosterol in fungi and changes the composition of other lipid components in the membrane, which leads to the death of fungal cells. Quickly relieves itching that often accompanies infections caused by yeast and dermatophytes. Does not change the composition of the microflora and pH of the vagina.

Pharmacokinetics of the drug Klion-D 100.

Metronidazole. When administered intravaginally, it is absorbed into the systemic circulation. Cmax in the blood is determined after 6–12 hours and is approximately 50% of the Cmax that is achieved (after 1–3 hours) after a single dose of metronidazole orally.

Miconazole. Systemic absorption of miconazole nitrate after intravaginal use is limited. 8 hours after application of the drug, 90% of miconazole is still present in the vagina. Unchanged miconazole is not detectable in either plasma or urine.

Use of the drug Klion-D 100 during pregnancy.

Contraindicated during pregnancy. Breastfeeding should be stopped during treatment.

Contraindications to the use of the drug Klion-D 100:

hypersensitivity to the components of the drug (including other nitroimidazole derivatives);

blood diseases, leukopenia (including history);

impaired coordination of movements, organic lesions Central nervous system (including epilepsy);

liver failure (if large doses are prescribed);

pregnancy;

period breastfeeding.

With caution:

diabetes mellitus;

microcirculation disturbance.

Side effects of the drug Klion-D 100.

Local: itching, burning, pain and irritation in the vagina; thick, white, mucous vaginal discharge with no odor or odor faint odor, frequent urination; a burning sensation or irritation of the penis in a sexual partner.

From the gastrointestinal tract: nausea, changes taste sensations, “metallic” taste and dry mouth, decreased appetite, cramping pain in abdominal cavity; vomiting, constipation or diarrhea.

Allergic reactions: urticaria, itching skin, rash.

From the nervous system: headache, dizziness.

Other: leukopenia or leukocytosis. IN in rare cases- coloration of urine in a red-brown color (due to the presence of a water-soluble pigment formed as a result of the metabolism of metronidazole).

Method of administration and dose of the drug Klion-D 100.

Intravaginally (deeply), after moistening the tablet with water.

Trichomonas vaginitis - 1 tablet. per day for 10 days in combination with oral metronidazole.

Nonspecific vaginitis or candidal vaginitis - 1 table. 2 times a day for 10 days, if necessary in combination with oral metronidazole.

Treatment with metronidazole should not last more than 10 days and be repeated more than 2-3 times a year.

Interactions of the drug Klion-D 100 with other drugs.

Like disulfiram, it causes ethanol intolerance. Concomitant use with disulfiram can lead to the development of various mental disorders, depression of consciousness.

Strengthens the effect of indirect anticoagulants (warfarin, etc.), which leads to an increase in the time of prothrombin formation.

Co-administration with barbiturates may accelerate the elimination of metronidazole, resulting in a decrease in its effect.

Cimetidine inhibits the metabolism of metronidazole, which may lead to an increase in its concentration in the blood serum and an increased risk of side effects.

When taken simultaneously with lithium preparations, the concentration of the latter in plasma may increase.

Special instructions when taking the drug Klion-D 100.

During the treatment period you should abstain from sexual intercourse.

If there are indications in the anamnesis of changes in the composition of peripheral blood, as well as when using the drug in high doses and/or with it long-term use control needed general analysis blood.

Metronidazole can immobilize treponemes, leading to a false-positive Nelson test.

With caution to be used by drivers during work vehicles and people whose profession is related to increased concentration attention (dizziness associated with taking the drug may occur).

Storage conditions for the drug Klion-D 100

List B.: In a dry place, protected from light, at a temperature of 15–30 °C.

Best before date drug Klion-D 100

- Descriptions and photographs in product cards may differ from what is presented in the pharmacy. Please check information with operators before placing an order.
- This product cannot be exchanged or returned on the basis of Resolution 55 of January 19, 1998.

Klion D is an antibacterial and antifungal pharmacological product used in gynecology.

International nonproprietary name

Metronidazole.

ATX and registration number

J01XD01 — Antimicrobials for systemic use.

Pharmacotherapeutic group

Intravaginal antiseptic and antifungal imidazole derivatives prescribed in therapeutic regimens for gynecological diseases.

Antibiotic or not

Combined antibacterial pharmacological product.

Mechanism of action

The effectiveness is due to the presence of active ingredients - metronidazole (group 5 nitroimidazole) and miconazole.

Metronidazole affects the synthesis of deoxyribonucleic acid by the bacterium, which subsequently leads to its death. Effective against protozoan microorganisms and anaerobic bacteria.

Miconazole is active against dermatophytes, yeasts, yeast-like and other pathogenic fungi. At the same time, it does not change the composition normal microflora vagina.

Acting simultaneously, they have antimicrobial, antiprotozoal, antifungal effects.

Composition and release form

Produced in the form of intravaginal, each of which contains:

metronidazole - 100 mg;
miconazole nitrate - 100 mg.

What does it treat?

Used in complex treatment for:

candidiasis;
bacterial and/or fungal vaginitis;
trichomoniasis;
giardiasis;
extraintestinal amoebiasis.

Contraindications to the use of Klion D

According to the instructions for use, the drug is not used if the patient’s medical history includes:

intolerance to the constituent components of the medication;
some blood diseases;
pathological processes in the liver;
congenital lactose intolerance or lactase deficiency;
CNS diseases.

In addition, it is not prescribed for initial stage pregnancy, during the lactation period and under the age of 12 years.

Directions for use and dosage

Intravaginally. The therapeutic regimen and its duration are determined by the gynecologist depending on the clinical manifestations of the disease.

For trichomoniasis

1 intravaginal pill into the vagina in the morning and evening. Highest daily dosage— 8 units of the drug.

For thrush

1 time per day, 1 suppository at night. Use within 10 days.

How to insert

Intravaginally. Pre-moistened with water.

Special instructions when using Klion D

When combined with alcohol, there is a risk of developing disulfiram-like reactions. In addition, alcohol-containing drinks neutralize the effect of the antibiotic.

During the course of use, it is necessary to exclude sexual contact.

Simultaneous therapy of the male sexual partner is necessary.

When using intravaginal suppositories, signs of leukopenia may be observed.

During menstruation

During pregnancy and lactation

Contraindicated in the early stages of pregnancy.

Prescription in the 2nd trimester is possible when all potential risks to the mother and fetus are taken into account. Maximum effectiveness can be achieved after 36 weeks of pregnancy.

Absorbed into mother's milk Therefore, use during the lactation period is prohibited.

In childhood

Not prescribed for girls under 12 years of age.

In old age

In older patients, pharmacokinetic properties may slow down.

For liver dysfunction

Not prescribed for liver failure.

For impaired renal function

Does not require changing the mode of application.

Side effects of Klion D

During treatment, sometimes unpleasant reactions of the body occur in the form of local manifestations:

itching, burning, discomfort in the vagina;
profuse, odorless white discharge;
irritation of the partner's penis.

The body's response from the gastrointestinal tract can be expressed in the form of nausea, diarrhea, constipation, dysfunction taste buds or decreased appetite.

In addition, some women report dizziness, headaches, allergic rash, and also frequent urge to urination and dark coloration of urine.

Discharge

Usage vaginal suppositories may cause unusual secretion in the vagina. The amount and nature of discharge depend on factors such as:

nature of the disease;
neglect of the pathological process;
patient's age;
the presence of other pathologies of the genitourinary system;
presence of allergies.

Burning

This is a normal vaginal reaction to the use of this type of pill. May appear on any day of use. It is not an indication for stopping treatment.

Effect on driving

Not identified.

Overdose

There is no information on cases of overdose. With simultaneous use of metronidazole orally, systemic effects may develop. In this case clinical manifestations poisonings are:

gastrointestinal disorders;
dizziness;
numbness of the limbs;
convulsive conditions;
motor dysfunction.

There is no specific antidote for metronidazole, so restorative therapy is carried out according to symptoms.

Drug interactions

Incompatible with medications containing:

ethanol;
disulfiram.

Not combined with non-depolarizing muscle relaxants.

Prescribed with caution when taking:

Cimetidine;
lithium preparations;
indirect anticoagulants;
inducers of microsomal liver enzymes.

Alcohol compatibility

Drinking alcoholic beverages while using intravaginal suppositories can lead to the following:

dizziness;
chest pain;
increased heart rate;
lowering blood pressure;
general weakness;
stomach ache;
facial skin hyperemia;
nausea and vomiting.

Conditions for dispensing from pharmacies

With a doctor's prescription.

How much does it cost in Russia and Ukraine

The price in Russia can vary from 320 to 600 rubles. In Ukraine it can be purchased in the price range from 160 to 260 grams.

Storage conditions

In a dark and dry place with a temperature no higher than 30˚C. Hide from children.

Best before date

Analogues

Substitutes are:

Gainex;
Limenda;
Neo-Penotran Forte et al.

Which is better - Klion or Klion D

The difference between intravaginal suppositories and traditional oral pills is not only in the method of use, but also in the composition. The presence of miconazole provides an additional local antimycotic effect, which is a clear advantage of this dosage form.