You are a fairly active person who cares and thinks about your respiratory system and health in general, continue to play sports, lead healthy image life, and your body will delight you throughout your life, and no bronchitis will bother you. But do not forget to undergo examinations on time, maintain your immunity, this is very important, do not overcool, avoid severe physical and strong emotional overload.
It's time to think about what you are doing wrong...
You are at risk, you should think about your lifestyle and start taking care of yourself. Physical education is required, or even better, start playing sports, choose the sport that you like most and turn it into a hobby (dancing, cycling, gym or just try to walk more). Do not forget to treat colds and flu promptly, they can lead to complications in the lungs. Be sure to work on your immunity, strengthen yourself, and be in nature and fresh air as often as possible. Do not forget to undergo scheduled annual examinations, treat lung diseases initial stages much simpler than in a neglected state. Avoid emotional and physical overload; if possible, eliminate or minimize smoking or contact with smokers.
It's time to sound the alarm! In your case, the likelihood of developing asthma is huge!
You are completely irresponsible about your health, thereby destroying the functioning of your lungs and bronchi, have pity on them! If you want to live a long time, you need to radically change your entire attitude towards your body. First of all, get examined by such specialists as a therapist and pulmonologist, you need to take radical measures otherwise everything may end badly for you. Follow all the doctors' recommendations, radically change your life, perhaps you should change your job or even your place of residence, completely eliminate smoking and alcohol from your life, and make contact with people who have such bad habits to a minimum, toughen up, strengthen your immune system, spend time in the fresh air as often as possible. Avoid emotional and physical overload. Completely eliminate all aggressive products from everyday use and replace them with natural ones. natural remedies. Do not forget to do wet cleaning and ventilation of the room at home.
Eufillin, solution: instructions for use
Compound
1 ampoule (5 ml) contains - active ingredient: aminophylline - 120 mg; excipient: water for injection;Description
Transparent colorless or slightly yellowish liquid.Pharmacological action
The effect of aminophylline is primarily due to the content of theophylline in it. Ethylenediamine enhances antispasmodic (relieving spasms) activity and promotes the dissolution of the drug. Important Features aminophylline are its solubility in water and the possibility of its intravenous administration. Eufillin relaxes the muscles of the bronchi, reduces the resistance of blood vessels, dilates the coronary (heart) vessels, lowers pressure in the system pulmonary artery, increases renal blood flow, has a diuretic (diuretic) effect, associated mainly with a decrease in tubular reabsorption (reabsorption of water in the renal tubules), causes an increase in the excretion of water and electrolytes in the urine, especially sodium and chloride ions. The drug strongly inhibits platelet aggregation (sticking together).
Blocks adenosine receptors, inhibits phosphodiesterase activity, increases the level of cyclic AMP, reduces - ionized calcium in smooth muscle cells.
Indications for use
Bronchial asthma, chronic obstructive bronchitis, pulmonary hypertension, breathing disorders (Cheyne-Stokes syndrome), migraine, cerebrovascular accident.Contraindications
Hypersensitivity (including to other xanthine derivatives: caffeine, pentoxifylline, theobromine), epilepsy, gastric and duodenal ulcers (in the acute stage - for oral forms, especially non-extended-release tablets), gastritis with increased acidity, severe arterial hyper- or hypotension, severe tachyarrhythmias, hemorrhagic stroke, retinal hemorrhage, children's age (up to 3 years, for prolonged oral forms - up to 12 years).Directions for use and doses
At emergency conditions adults are administered intravenously (i.v.) loading doses at the rate of 5.6 mg/kg body weight (10-20 ml of aminophylline is diluted in 10-20 ml of 0.9% sodium chloride solution, 250-500 ml of physiological solution are added, administered over 30 minutes) and maintenance (0.9 mg /kg for 1 - 3.5 hours) doses. If the patient was taking theophylline, the dose should be reduced by 50% or more.
Maximum daily dose in adults it is 10-13 mg/kg (0.4-0.5 ml/kg), in children aged 6-17 years - 13 mg/kg body weight (0.5 ml/kg), from 3 years to 6 years – 20-22 mg/kg (0.8-0.9 ml/kg).
Side effect
From the outside nervous system: dizziness, headache, insomnia, agitation, anxiety, irritability, tremor.
From the cardiovascular system: palpitations, tachycardia (including in the fetus when taken by a pregnant woman in the third trimester), arrhythmias, decreased blood pressure (BP), cardialgia, increased frequency of angina attacks.
From the outside digestive system: gastralgia, nausea, vomiting, gastroesophageal reflux, heartburn, exacerbation peptic ulcer, diarrhea, with long-term use- loss of appetite.
Allergic reactions: skin rash, itchy skin, fever.
Other: chest pain, tachypnea, flushing, albuminuria, hematuria, hypoglycemia, increased diuresis, increased sweating.
Side effects decrease with decreasing dosage of the drug.
Local reactions: compaction, hyperemia, pain at the injection site.
Overdose
Symptoms: loss of appetite, gastralgia, diarrhea, nausea, vomiting (including blood), gastrointestinal bleeding, tachypnea, facial skin flushing, tachycardia, ventricular arrhythmias, insomnia, motor agitation, anxiety, photophobia, tremor, convulsions. In case of severe poisoning, epileptoid seizures may develop (especially in children without any warning signs), hypoxia, metabolic acidosis, hyperglycemia, hypokalemia, decreased blood pressure, necrosis skeletal muscles, confusion, renal failure with myoglobinuria.
Treatment: drug withdrawal, gastric lavage, administration activated carbon, laxatives medicines, siphon enemas with the introduction of a combination of polyethylene glycol and polyelectrolyte solutions, forced diuresis, when the drug level in plasma is more than 50 mcg/ml - hemosorption, plasmapheresis are indicated; hemodialysis or peritoneal dialysis are less effective. Symptomatic therapy: monitor hemodynamic parameters and provide respiratory support (oxygen supply and mechanical ventilation). At convulsive syndrome– intramuscular administration of diazepam 0.1-0.3 mg/kg (but not more than 10 mg); the use of barbiturates is contraindicated! At severe nausea and vomiting - metoclopramide or ondansetron (iv). As a specific antidote for aminophylline intoxication, intravenous jet administration of riboxin (inositol) diluted in physiological solution is used (glucose or dextrose solutions should not be used for dilution).
Interaction with other drugs
Pharmaceutically incompatible with acid solutions.
Increases the likelihood of developing side effects GCS, MCS (hypernatremia), means for general anesthesia(increases the risk of ventricular arrhythmias), drugs that excite the central nervous system (increases neurotoxicity).
Rifampicin, phenobarbital, phenytoin, rifampicin, isoniazid, carbamazepine, sulfinpyrazone, aminoglutethimide, oral estrogen-containing contraceptives and moracizine, being inducers of microsomal oxidation, increase the clearance of aminophylline, which may require an increase in its dose.
When used simultaneously with macrolide antibiotics, lincomycin, allopurinol, cimetidine, isoprenaline, enoxacin, ethanol, disulfiram, fluoroquinolones, fluvoxamine, viloxazine, recombinant interferon alpha, methotrexate, mexiletine, propafenone, thiabendazole, ticlopidine, verapamil and when vaccinated against flu intensity of action aminophylline exposure may increase, which may require a dose reduction.
Enhances the effect of beta-agonists and diuretics (including by increasing glomerular filtration), reduces the effectiveness of drugs containing lithium and b-blockers.
Due to the possibility of potentiating the action of anticoagulants, it is necessary to observe special caution when used together.
Features of application
Before administration, the drug solution must be warmed to body temperature. Aminophylline is pharmaceutically incompatible with solutions of glucose, fructose and levulose. When preparing for infusion, the pH of the solutions used should be taken into account. With caution, the drug is prescribed simultaneously with anticoagulants, with other theophylline or purine derivatives. During treatment, it is prohibited to take substances containing xanthine derivatives (tea, coffee).Precautions
Intravenous administration should be carried out under careful monitoring of blood circulation, breathing and general condition patient (heart rate, blood pressure, number of respirations).
Administration of theophylline derivatives is associated with high probability development toxic effect due to its low therapeutic breadth.
Determination of theophylline content is recommended at the beginning of treatment, before increasing the dose in the absence of expected treatment results, when using high doses, when any side effect occurs, when any change physiological state, as well as prescribing a drug that affects the elimination of theophylline or a new drug with an unknown effect on the elimination of theophylline.
Leads to development more side effects and is likely to be less effective in controlling asthma symptoms (including nocturnal asthma).
During treatment bronchial asthma Theophylline preparations should not be considered as drugs of choice; they should be used in patients with an inadequate response to anti-inflammatory and β-adrenergic drugs.
During an attack of bronchial asthma in adults, routine intravenous administration of aminophylline in addition to β 2 -agonist therapy is not indicated. This does not lead to an additional bronchodilator effect, but is accompanied by an increase in the frequency of side effects.
Cases of hypotension and cardiac arrest have been reported after rapid administration through a central venous catheter.
Release form
5 ml in ampoules in packaging No. 10, No. 5 x 2.Storage conditions
In a place protected from light, at a temperature not exceeding 25ºС. Keep out of the reach of children.Best before date
2 years. Do not use after expiration date.Conditions for dispensing from pharmacies
By doctor's prescription.Self-medication can be harmful to your health.
You should consult your doctor and read the instructions before use.
Bronchopulmonary diseases are among the most common not only among the adult population of the planet, but also among children of almost any age. Treatment of respiratory diseases has already formed into an entire branch of medicine. One of the favorite drugs that has an invariable effect is Euphyllin (euphyllini). It has pronounced activity and helps fight pulmonary insufficiency, relieves cough. "Eufillin" is prescribed to children, observing some important precautions and restrictions.
The use of Eufillin has become widespread due to its pharmacokinetic properties. Active ingredient, taken as a basis, is theophylline. Internationally pharmaceutical market known as aminophylline. It has a pronounced bronchodilator effect. What does it mean?
The main effect of the drug is that, through complex chemical interactions, the drug reduces the motor and contractile activity of smooth muscles.
Of course, this applies not only to bronchi of different diameters, but also to blood vessels, the liver, the uterus, and the stomach. At the same time, aminophylline increases the amount of blood that passes through the kidneys, which contributes to an increase in diuresis.
Action on respiratory tract consists of the following steps:
A decrease in smooth muscle tone occurs due to a decrease in the supply of calcium ions through cell membranes due to blocking purine receptors. Relaxation of the bronchi is necessary for the free passage of mucus and improved respiratory activity.
The diaphragm begins to actively move, which is an auxiliary mechanism for ventilation of the respiratory system. At the same time, the contractile activity of the intercostal muscles increases. They contribute to the full opening of air flow paths.
Due to activation muscle fibers the corresponding center in the brain is indirectly stimulated - the respiratory rate increases.
"Eufillin" is as relevant for children as for adult patients, but its use is significantly limited due to some characteristics of childhood.
The use of the drug is not limited only to the treatment of diseases of the bronchi and lungs. "Eufillin" and its analogues are used in complex treatment due to the following properties:
- stimulate cardiac activity;
- reduce the tone of blood vessels carrying blood to the brain and kidneys;
- reduce the formation of blood clots in vessels of different sizes;
- improve rheological properties blood;
- increase emissions hydrochloric acid in the stomach.
It can be prescribed as a component of therapy for edema syndrome of renal origin.
Analogues of the drug
A large number of medicines on the pharmaceutical market allows the patient and the doctor to choose exactly the drug that will provide the maximum, necessary action. At the same time, it will be available for purchase at a price, and it can be easily purchased in a specific locality. Many companies produce synthesized analogues of the original "Eufillin", which are based on 
contain the same active ingredients.
In the pharmacy you can find medicines with the active element “theophylline” as a base, but each has its own commercial name. For example, drugs produced in India, Slovenia, and Ukraine are widely represented: Teopek, Theotard, Theophylline, Neophylline, Unicontin. They are available in the form of tablets with different concentrations and dosages, solutions for injection.
Indications for use of "Eufillin" in children
IN childhood There are a number of serious restrictions on the use of Eufillin precisely because of such a diverse spectrum of influence. Children under three months are not subject to therapeutic effects by this means. In the age interval between one and three years, it is preferable to use aminophylline treatment in the form of inhalations. Children under six years of age are prescribed electrophoresis with aminophylline; for older children, the drug is administered intravenously.
Any diseases respiratory system with a spastic component, cough, difficulty breathing are indications for prescribing aminophylline:
- bronchitis with asthma-like attacks;
- obstructive bronchitis;
- emphysema;
- acute laryngitis with spastic attacks;
- swelling of the airways at any level;
- bronchial asthma;
- pneumonia.
In addition to the above-mentioned diagnoses, it is used as a palliative in the treatment of cerebrovascular insufficiency, diseases of the cardiovascular system, and spastic conditions of the smooth muscles of other internal organs.
Treatment of infants up to one year
A child under three months of age cannot be treated with Eufillin. And even at this age, the use is strictly limited, only in case of absolute ineffectiveness of other bronchodilators. If there is a threat of pulmonary edema for a child of several months, as well as bronchospasm, acute hypoxia, then the drug is prescribed. Its dose is selected very carefully, and the doctor monitors the body’s reaction and the result obtained around the clock.
Newborn children cannot take electrophoresis tablets for obvious reasons. All medications are administered to them intravenously, through droppers. Calculation of the amount for relief of an acute condition is carried out based on six milligrams per 1 kilogram of the baby’s body weight. After the threat of hypoxia disappears, the doctor can adjust the dose:
- 3 - 6 months of age: multiply the number of weeks by 0.07 and add 1.7 mg;
- age 6 - 12 months: weeks multiply by 0.05 and add 1.25 mg.
The frequency of injections in the first half of life is up to three times a day. Children aged six months and older, if necessary, are allowed to administer Eufillin no more than four times a day.
Young patients are very sensitive to drugs of this type. A reaction to treatment may include convulsions and respiratory arrest, so the doctor monitors the condition of such patients especially carefully.
Treatment of young children
In the second year of life children's body It’s already stronger, but you shouldn’t lose your vigilance. The method for selecting the correct, optimal dose remains in force and cannot be deviated from. It is preferable to choose the route of entry of “Eufillin” into the body by injection, drip. This allows you to protect against unwanted side effects of rapid administration.
The instructions for calculating doses take into account not only the patient’s age, but also the degree of development of the process: acute or chronic. Thus, for children from one to three years old, the amount of the drug per kilogram of body weight in case of acute illness should not exceed 5 mg and be administered orally up to 4 times a day. Children with chronic forms pulmonary pathologies, it is recommended to prescribe a dose of no more than 4 mg per kilogram with the same frequency of administration. Children from three to five years old can receive the medicine in an amount of 4 to three milligrams, depending on the severity of the disease, with a frequency of administration up to four times a day.
The maximum daily amount is limited to 7 mg per kilogram of body weight for a single dose and no more than fifteen milligrams per kilogram per day. These doses can be administered through a therapeutic enema, which is less traumatic for children and adult patients and reduces the possibility of an adverse reaction.
Self-treatment of small children with Eufillin is unacceptable!
Inhalation treatment
One of the valuable qualities of the drug is the ability to provide the necessary effect when different forms receipts, which makes it possible to use "Eufillin" for children, selecting the dosage and method of administration. The most convenient and in an efficient way introductions for children over three years of age are inhalation and iontophoresis, which can be carried out even at home using an Elfor electrophoresis and galvanization apparatus.
The inhalation effect of inhaling “Eufillin” in a vapor state occurs quickly. The medicine acts directly in the target organ, which increases the effectiveness of treatment. Modern inhalers make it possible to carry out procedures as compactly as possible, with the necessary frequency and efficiency.
For example, an inhalation “Nebulizer” can be portable, which makes it possible to inhale a therapeutic mixture with “Eufillin” directly in a hospital ward or at home. One of the recipes for preparing a solution with “Eufillin” for inhalation is as follows: 
- 100 ml of water must be mixed with the contents of one ampoule of diphenhydramine solution and the same amount of “Eufillin”, the concentration percentage of which is 2%;
- inhalation is carried out no more often than with a break of up to 6 hours;
- The patient's neck is in a fixed state for maximum air flow.
After inhalation medicinal mixture, the child must spend in calm state at least 30 minutes. We remind you once again that self-prescription of Eufillin is unacceptable!
When is Eufillin prescribed in ampoules?
Any solutions for parenteral, rectal or inhalation administration are indicated for acute conditions, for the rapid relief of a life-threatening attack or consequences. Also, drugs in ampoules are preferable if there are violations from gastrointestinal tract, the patient is in unclear consciousness, inadequate. Another indication for prescribing injection forms is old age, childhood.
Features of treatment with a tablet drug
Conscious age of seven years and older allows taking tablet forms. Instructions for the use of tablets for children have been developed for aminophylline. Here, too, the doctor adheres to a strict prescribing regimen, which contains the following instructions:
- A child's weight up to 30 kg requires prescription of more than 20 mg per 1 kg per day;
- from three to seven years maximum dose is 100 mg per day.
You need to take the pills a large number fluids, preferably plain water, to prevent kidney complications.
Compress with Eufillin
There are recommendations to put it on the back small child a compress containing a solution of Eufillin, dimexide, and no-shpa to relieve a strained cough. There is no reliable information about its effectiveness, but allergic reaction you can get it. It is best to consult your doctor to avoid undesirable consequences such treatment.
Contraindications and side effects
There is a list absolute contraindications to prescribe treatment with Eufillin not only for children, but also for adults:
- epileptic activity;
- convulsive syndrome;
- renal failure;
- acute and chronic liver failure;
- mental disorders.
The following pathologies serve as relative limitations:
- organic disorders of the cardiovascular system;
- diseases of the gastrointestinal tract with high acidity.
In addition to restrictions on use and contraindications, there is a list of possible side effects:
- allergic reactions various manifestations: from skin rashes to Quincke's edema;
- gastrointestinal disorders;
- attacks of palpitations, tachycardia;
- vegetative reactions.
Children are susceptible to adverse reactions from the nervous system. They may be agitated, have trouble sleeping, be capricious, and react to the drug with seizures.
Interaction with other drugs and overdose
Antimicrobial agents potentiate the effect of Eufillin; this must be taken into account when calculating the dose. Antidiarrheal drugs reduce the absorption of the drug and its effectiveness.
Steroid drugs greatly increase the likelihood of adverse reactions with simultaneous use of a bronchodilator. That is why only a doctor decides the issue of treatment with Eufillin, its dose and frequency of administration, especially for children.
Symptoms of drug poisoning, convulsions, respiratory arrest, hypercapnia - this is an emergency condition that requires immediate discontinuation of Eufillin, rinsing the stomach, and administering antidotes.
Name:
Name: Euphylline (Euphyuinum)
Indications for use:
Eufillin is used for bronchial asthma and bronchospasms ( sharp narrowing bronchial lumen) various reasons(mainly to relieve attacks), hypertension in the pulmonary circulation ( high blood pressure in the vessels of the lungs), also in cardiac asthma, especially when attacks are accompanied by bronchospasm and breathing disorders of the Cheyne-Stokes type. It is also recommended for relieving (relieving) cerebral vascular crises (cerebral vascular crises) of atherosclerotic origin and improving cerebral circulation, reducing intracranial pressure and cerebral edema during ischemic strokes ( acute disorder cerebral circulation), also with chronic failure cerebral circulation. The drug improves renal blood flow and can be used if indicated.
Pharmacological action:
The effect of aminophylline is primarily due to the content of theophylline in it. Ethylenediamine enhances antispasmodic (relieving spasms) activity and promotes the dissolution of the product. The mechanism of action of aminophylline is basically similar to the mechanism of action of theophylline. Important features of aminophylline are its solubility in water and the possibility of its parenteral (intravenous or intramuscular) administration. Like theophylline, aminophylline relaxes the bronchial muscles, reduces the resistance of blood vessels, dilates the coronary (heart) vessels, lowers pressure in the pulmonary artery system, increases renal blood flow, and has a diuretic (diuretic) effect associated primarily with a decrease in tubular reabsorption (reabsorption of water in the renal tubules ), causes an increase in the excretion of water and electrolytes, especially sodium and chlorine ions, in the urine. The drug strongly inhibits platelet aggregation (sticking together).
Euphyllin method of administration and dosage:
Eufillin is prescribed orally, into muscles, veins and in microclyses. Aminophylline solutions are not injected under the skin, as they cause tissue irritation. The method of administration depends on the specifics of the case: when acute attacks bronchial asthma and strokes are administered intravenously, in less severe cases - intramuscularly or orally. Adults take 0.15 g orally after meals 1-3 times every day. Children are given orally at the rate of 7-10 mg/kg per day in 4 divided doses. The duration of treatment ranges from several days to several months. Adults are administered slowly (over 4-6 minutes) 0.12-0.24 g (5-10 ml of 2.4% solution) into a vein, which is pre-diluted in 10-20 ml of isotonic sodium chloride solution. If palpitations, dizziness, or nausea occur, the rate of administration is slowed down or switched to drip administration, for which 10-20 ml of a 2.4% solution (0.24-0.48 g) is diluted in 100-150 ml of isotonic sodium chloride solution; administered at a rate of 30-50 drops per minute. If it is impossible to administer into a vein, 1 ml of a 24% solution is injected intramuscularly. Parenterally (bypassing digestive tract) aminophylline is administered up to 3 times a day for no more than 14 days. Children are administered intravenously at a single dose of 2-3 mg/kg. The drug is not recommended for children under 14 years of age (due to possible side effects). You can prescribe aminophylline rectally (into the rectum) in the form of microenemas. Dose for adults 10-20 ml; for children - less, according to age. Higher doses aminophylline for adults orally, intramuscularly and rectally: single dose - 0.5 g, daily - 1.5 g; into a vein: single - 0.25 g, daily - 0.5 g. Higher doses for children orally, intramuscularly and rectally: single - 7 mg/kg, daily - 15 mg/kg; intravenously: single dose - 3 mg/kg.
Eufillin contraindications:
The use of aminophylline, especially intravenously, is contraindicated in cases of sharply low blood pressure, paroxysmal tachycardia, extrasystoles, epilepsy. The product should also not be used for heart failure, especially associated with myocardial infarction, when there are coronary insufficiency(discrepancy between blood flow through the cardiac arteries and the heart’s need for oxygen) and disorders heart rate.
Eufillin side effects:
Dyspeptic disorders (digestive disorders), with intravenous administration, dizziness, hypotension (low blood pressure), headache, palpitations, convulsions, with rectal use, irritation of the rectal mucosa.
Release form:
Powder; tablets of 0.15 g in a pack of 30 pcs.; ampoules of 10 ml of 2.4% solution and 1 ml of 24% solution in packs of 10 pcs.
Synonyms:
Aminophylline, Aminocardol, Ammophylline, Diaphylline, Genophylline, Metaphylline, Neophylline, Novophylline, Syntophylline, Theophylline, Theophylline ethylenediamine.
Storage conditions:
List B. In a place protected from light.
Additionally:
Combination product containing theophylline and ethylenediamine.
Eufillin is included in the product trisolvin. Theophylline is also included in the combination products coritrate, theoasthaline, theoasthaline forte, theoasthaline SR.
Attention!
Before using the medication, you should consult your doctor.
The instructions are provided for informational purposes only.
Relaxes the smooth muscles of all internal organs, such as the uterus, bladder, bronchi, blood vessels, biliary tract, etc. Thanks to the relaxation of smooth muscles, Euphyllin relieves spasms and excessive contractions of internal organs caused by any causative factor. Thus, Eufillin dilates blood vessels, relieves bronchospasm, reduces contractile activity uterus, stopping the threat of miscarriage or premature birth etc.
Release forms, names and composition of Eufillin
Currently, Eufillin is produced by various pharmaceutical factories in the countries former USSR, in most cases under the same name - "Eufillin". However, some pharmaceutical factories, having decided to register their own name, which would distinguish their product from many others, use various options names containing the word "Eufillin". Usually in such cases, some word or abbreviation is added to “Eufillin”, which is related to the name of the drug’s manufacturing plant, for example, Eufillin-Darnitsa, Eufillin-UBF and some others. However, all these drugs are actually the same thing, since they are produced using the same technology, developed back in the USSR. In the following text, under the name "Eufillin" we will mean all the described medicines, which differ from each other only by a few letters in the name.So, Eufillin is available in three dosage forms:
- Tablets for oral administration;
- Solution for intravenous administration;
- Solution for intramuscular injection.
As active substance all dosage forms of Eufillin include the substance aminophylline in the following different quantities:
- Tablets – 150 mg of aminophylline;
- Solution for intravenous administration – 24 mg of aminophylline per 1 ml (2.4%);
- Solution for intramuscular administration – 240 mg of aminophylline per 1 ml (24%).
In solutions for intramuscular and intravenous injections The auxiliary components include only purified water and a preservative, which may be different for drugs produced by different pharmaceutical factories. Therefore, to obtain complete and accurate information about auxiliary components For this particular injection solution, it is recommended that you carefully study the instructions included with the medicine. In Euphyllin tablets as excipients includes calcium stearate and potato starch.
Tablets are available in packs of 10, 15, 20, 25, 30, 40, 50, 75, 80 and 100 pieces. A solution for intravenous administration of 2.4% is available in ampoules of 5 ml and 10 ml. A solution for intramuscular administration of 24% is available in 1 ml ampoules.
Eufillin - recipe
The prescription for Eufillin solution for intravenous injection is written as follows:
Rp: Sol. Euphyllini 2.4% – 10 ml
D.t.d. No. 10 inamp.
S. dilute with 0.9% NaCl ( saline solution) 10 ml, administered intravenously slowly in 10 ml increments.
The prescription for Euphyllin solution for intramuscular injection is written in exactly the same way as for the solution for intravenous administration, but with the only difference - after the words “Sol. Euphyllini” the concentration of 24% is indicated. After the letter S, the doctor can indicate how the solution should be administered. However, often the doctor does not write in the prescription how to administer the solution, but explains the rules and methodology for performing injections to a person in words.
The prescription for Eufillin tablets is written as follows:
Rp: Tab. Euphyllini 150 mg
D.t.d. No. 10 intab.
S. Take 1 tablet 3 times a day.
In recipes, after the letters “Rp” the Latin name of the drug (in this case Euphyllini) and its dosage form (Sol. - solution or Tab. - tablets) are indicated. After the name, the concentration of the solution or the dosage of the tablets is written. On the next line after the letters "D.t.d." under the No. icon the number of ampoules or tablets that the pharmacist must dispense to the person presenting the prescription is indicated. Finally on last line After the letter “S” of the prescription, the doctor writes how the drug should be used. This information is intended for the patient himself.
Therapeutic effect of the drug
Eufillin reduces the contractile activity of smooth muscles that are present in those internal organs, which need to perform spastic muscle contractions in order to move their contents, for example, bronchi, bile ducts, uterus, bladder, blood vessels, intestines, etc. All of the listed organs are involved in the movement of any content: air passes through the bronchi, blood flows through the vessels, etc. Accordingly, to perform their functions, these internal organs perform contractile movements provided by smooth muscles.If the smooth muscles tense excessively, then instead of rhythmic contractions a spasm develops, the lumen of the organ sharply narrows, and various substances either stop transporting altogether, or the speed of this process slows down significantly. After all, a small amount of blood flows through a narrow lumen in a blood vessel, and air also passes through sharply narrowed bronchi with great difficulty, etc. To restore the normal patency of the organ and ensure regular transport of substances at the required speed and in the required quantity, it is necessary to eliminate the spasm of the smooth muscles, that is, to relax them. After the muscles relax, the lumen of the organ expands and all substances can pass through it unhindered. Eufillin causes just such relaxation of smooth muscles and, accordingly, relief of their spasm with restoration of patency.
Since smooth muscles are present in many internal organs, and Eufillin has a non-selective effect, when it is used, all smooth muscle structures relax and, accordingly, multiple effects occur on the part of various systems.
Thus, Eufillin has the following therapeutic effects on various organs and fabrics:
- Relaxes the muscles of the bronchi, expands their lumen and, thereby, relieves bronchospasm;
- Stimulates work respiratory center in the brain;
- Reduces the number and severity of apnea attacks;
- Increases the strength and frequency of heart contractions;
- Increases the intensity of cardiac blood flow and myocardial oxygen demand;
- Reduces the tone of blood vessels, relaxing them and lowering blood pressure;
- Improves peripheral microcirculation in tissues;
- Increases blood supply to the kidneys and, thereby, has a moderate diuretic effect;
- Expands the bile ducts, relieving spasm and pain;
- Prevents the development of allergic reactions;
- Reduces the adhesion of platelets to each other and the formation of blood clots;
- Increases the resistance of red blood cells to deformation;
- Has a tocolytic effect (relaxes the uterus and eliminates the threat of miscarriage or premature birth);
- Increases the acidity of gastric juice;
- IN high dosages may provoke epileptic attacks.
Eufillin - indications for use
Indications for the use of tablets and injection solutions are different and are reflected in the table.| Indications for the use of Eufillin solutions for intravenous and intramuscular injections | Indications for the use of Euphyllin tablets |
| Asthmatic status | Broncho-obstructive syndrome (bronchospasm) of any origin, for example, with asthma, pulmonary hypertension, sleep apnea, COPD, etc. |
| Apnea in newborns | |
| Cerebral circulatory disorders such as ischemia (as part of complex therapy) | |
| Left ventricular failure, combined with bronchospasm and Cheyne-Stokes respiration | |
| Renal edema (as part of complex therapy) |
That is, the tablets are recommended for use when chronic course diseases with periodically recurring episodes of bronchospasm. And intravenous or intramuscular injections indicated only for acute, emergency, life-threatening conditions, regardless of the cause that provoked them.
Non-standard use of the drug (for what procedures is it used)
Eufillin is used in the treatment of various conditions and diseases in which it is necessary to improve blood microcirculation and reduce tissue tension and tone. In such situations, it is recommended to deliver Eufillin to the affected areas during electrophoresis, as this ensures penetration of the drug into the tissue.Electrophoresis with Eufillin is used in the following cases:
- Osteochondrosis;
- Arthrosis and arthritis of various joints;
- Chronic bronchitis;
- Cerebrovascular accident;
- Increased intracranial pressure;
- Hypertonicity or hypotonicity of muscles in children;
- Head dysplasia femur in infants;
- Long-term non-closure of the fontanel in infants;
- Nerve lesions in adults (eg, facial nerve).
Instructions for use
Let's consider the various nuances of using Eufillin tablets and solutions separately to avoid confusion.Eufillin tablets - instructions for use
The tablets should be taken after meals, swallowed whole and washed down with a small amount of water (half a glass is enough). If necessary (for example, if you have difficulty swallowing), the tablet can be broken into halves or quarters and swallowed one after another. To treat bronchospasm, adults need to take Eufillin 150 mg (1 tablet) 2 to 3 times a day. For children, the dosage of tablets is calculated individually based on body weight, based on the ratio of 7 - 10 mg per 1 kg of weight. The amount of Eufillin calculated in this way is divided into 4 doses. For example, a child weighing 20 kg needs to take 10 * 20 = 200 mg of Euphyllin per day. This quantity– 200 mg should be divided into 4 doses – 200/4 = 50 mg. Thus, a child weighing 20 kg should take 50 mg (1/3 tablet) of Euphyllin 4 times a day.
Maximum permissible single dose Eufillina for adults is 500 mg (3.3 tablets), and the daily dose is 1500 mg (10 tablets). For children, the highest single dosage is 10 mg per 1 kg, and the daily dosage is 15 mg per 1 kg.
The duration of therapy with Eufillin is determined individual characteristics body and the rate of normalization of the condition. So, for some people, to relieve bronchospasm, it is enough to take Eufillin for several days, while others will have to take the drug for 2 to 5 months in a row. The duration of treatment is determined by the attending physician, who knows the person’s medical history, is aware of his reactions to drugs, the individual rate of normalization of the condition and the decrease in bronchial smooth muscle tone.
If a person takes Eufillin on his own, then it is necessary to stop therapy no earlier than 4 to 5 days after complete relaxation of the bronchi has occurred, which is manifested in ease of breathing.
In addition to the specified scheme for using Eufillin tablets, which implies self-treatment, which initially consisted of taking the drug orally, there is also the option of maintenance therapy. This maintenance therapy consists of a course of use of Eufillin tablets after relief of an acute condition using intravenous injections of a solution of the same drug. Maintenance therapy with Eufillin is aimed at maintaining the results achieved by injections, as well as achieving stable remission and preventing repeated episodes of severe, life-threatening bronchospasm.
Maintenance therapy begins with taking the minimum dosage of Eufillin tablets, which can be increased by 25% every three days, until the maximum is reached. permissible quantities use of the drug. The duration of therapy is determined by the rate of onset of stable remission with the absence of episodes of bronchospasm.
So, for adults, the minimum maintenance dosage is as follows – 1 tablet every 6 hours (that is, take 1 tablet 4 times a day). After three days, the dosage can be increased by 25%, that is, by 1 tablet and take not 4, but 5 tablets per day. This fifth tablet can be divided into four parts and taken 1 + 1/4 tablets 4 times a day. But you can have one extra tablet Take whole in one of four daily doses. For example, take 2 tablets at once in the morning, and one tablet at a time during the remaining three doses. The maximum daily dosage for adults for maintenance treatment is 900 mg, which corresponds to 6 tablets.
For children, the initial dosage of maintenance therapy is calculated based on body weight at a ratio of 16 mg per 1 kg. The calculated amount of the drug is divided into 3 to 4 doses per day. If necessary, as for adults, you can increase it every 3 days. daily dosage by 25% until the maximum permissible values are reached. The maximum daily dosage for maintenance treatment in children is determined by age and is as follows:
- Children under 1 year– dosage is calculated using the formula: 0.3*age in weeks + 8;
- Children 1 – 9 years old– the maximum permissible daily dosage is 22 mg per 1 kg;
- Children 9 – 12 years old– 20 mg per 1 kg;
- Children 12 – 16 years old– 18 mg per 1 kg.
- Children from 0 to 6 months – dosage is calculated using the formula: 0.07 * age in weeks + 1.7. The calculated amount of Euphyllin is given to the child every 8 hours (3 times a day).
- Children 6 – 12 months – calculated using the formula: 0.05*age in weeks + 1.25. The calculated amount of the drug is given to the child every 6 hours (4 times a day).
- Children 1 – 9 years old– 5 mg per 1 kg every 6 hours.
- Children 9 – 12 years old
- Children 12 – 16 years old
- Adults who do not smoke or have liver disease – 3 mg per 1 kg every 6 hours.
- Adults smoking – 4 mg per 1 kg every 6 hours.
- Adults with liver disease – 2 mg per 1 kg every 8 hours.
Eufillin ampoules - instructions for use
The ampoules may contain a solution of Eufillin of different concentrations, intended, respectively, for intravenous or intramuscular administration. If the ampoule indicates a concentration of 2.4% or 2%, then this is a solution for intravenous administration. And if the concentration of the solution is 24%, then it is intended for intramuscular administration. That is, the difference in the concentration of solutions for intravenous and intramuscular injections is 10 times. These solutions are not interchangeable, so before performing an injection you should always look carefully at the ampoule and read the concentration of this particular drug. Intravenous administration of Eufillin is used only in emergency conditions, when it is necessary to quickly relieve life-threatening bronchospasm. When the acute condition is relieved, they switch to maintenance administration of Eufillin tablets or intramuscular injections. At the same time the best option are tablets, and intramuscular injections are used only in cases where a person for some reason cannot take tablets orally (for example, stomach diseases, etc.). However, at the first opportunity, it is recommended to switch from intramuscular injections to taking tablets.
So, in acute emergency conditions, Eufillin is administered intravenously (a “dropper” is placed). The dosage is calculated or determined individually depending on the age and weight of the person:
- Adults and teenagers over 16 years of age – 6 mg per 1 kg of weight;
- Infants up to 3 months – administer 30–60 mg per day;
- Children 4 – 12 months – administer 60–90 mg per day;
- Children 2 – 3 years old– administer 90–120 mg per day;
- Children 4 – 7 years old– administer 120–140 mg per day;
- Children 8 – 16 years old– administer 250–500 mg per day.
For status asthmaticus, regardless of weight, 720–750 mg of Eufillin is administered intravenously (30–32 ml of solution from ampoules is diluted in 250 ml of physiological solution) for 1–2 hours.
Intramuscularly at various states For adults, Eufillin is administered at 100–500 mg per day, and for children, the dosage is calculated individually according to the ratio of 15 mg per 1 kg. Moreover, the daily dosage is divided into 3 - 4 equal parts and, accordingly, 3 - 4 injections are given per day.
Intramuscular and intravenous use of Eufillin should be as short as possible, and at the first opportunity it is necessary to switch to taking tablets. The maximum permissible duration of injection administration of Eufillin solutions is 14 days.
Gynecologists prescribe Eufillin in the complex treatment of gestosis and edema of pregnant women, placental insufficiency, as well as other conditions that require immediate use of the drug due to a threat to the life of the mother. Thus, Eufillin is not completely safe drug, but the degree of its “harmlessness” is quite sufficient for use during pregnancy if indicated.
Therefore, if a doctor has prescribed Eufillin to a pregnant woman, she can take it, strictly observing the prescribed dosage and duration of therapy. But if any signs that worry a woman appear, you should not use the drug on your own.
Eufillin for children
For children under 3 months of age, Eufillin in injections and tablets is prescribed only vital signs. Even at older ages, intravenous and intramuscular injections of the drug are carried out only in emergency conditions, since Eufillin has a pronounced effect on the child’s cardiovascular system, as a result of which, after each administration of the solution, the baby should be under the supervision of a doctor.And at older ages, tablets are quite widely used in the practice of pediatricians, who prescribe them for the treatment of bronchospasms, which often develop in children suffering from bronchitis. In tablet form, this is the main use of Eufillin. However, pediatricians for the treatment of bronchitis prefer to prescribe Eufillin not in tablets, but in the form of inhalations, for the production of which a 2.4% solution is used.
IN infancy(up to a year) Eufillin is used to relieve muscle hypertonicity, reduce intracranial pressure, and also to eliminate developmental delays associated with cerebrovascular accidents. However, in infants, Eufillin is used, as a rule, during the physiotherapeutic procedure of electrophoresis, since it allows the medicine to be administered directly to the areas where it is needed. That is, administration of the drug during electrophoresis allows one to avoid pronounced systemic effects on blood vessels, bronchi, bile ducts and kidneys, as well as possible irritation of the stomach and intestines, and at the same time create the necessary concentration of Euphyllin in the affected tissues.
Dosages of aminophylline for electrophoresis, inhalation and oral administration are determined by the doctor. Typically, the dosage of Eufillin tablets for a child is calculated according to the ratio of 7–10 mg per 1 kg, after which the resulting value is divided into 3–4 doses per day.
Use for cough
Eufillin expands the bronchi, as a result of which sputum is more easily removed, and a person can breathe normally without whistling, wheezing and painful coughing attacks. If the adult or child is not bothered by seizures painful cough, in which he literally suffocates, then there is no need to use Eufillin. In such situations, expectorant medications are quite sufficient. But if an adult or child coughs heavily and painfully, he develops entire attacks that prevent him from breathing and literally has a suffocating effect, then it is recommended to take Eufillin 3 times a day. Adults are recommended to take 1 tablet, and children – 1/4 - 1/3 tablet. As the cough decreases, you should switch to taking only one dose of Eufillin (1 tablet for adults and 1/4 - 1/3 for children) at night so that you can sleep peacefully without coughing attacks, which quite often occur with transition from vertical to horizontal position. A minimum of 6-hour interval should be maintained between taking tablets.
With a purpose speedy recovery 10 - 15 minutes after taking the Eufillin tablet, it is recommended to carry out regular inhalation mineral water or saline solution. This will speed up the removal of sputum and, accordingly, the recovery process will be faster.
Eufillin for inhalation
Inhalations with Eufillin are prescribed for obstructive bronchitis, since the drug expands the bronchi, relieving spasm, and facilitates the removal of sputum. However, the drug has all these effects only when it enters systemic blood flow, that is, when taken orally or injected.Inhalation use of Eufillin belongs to the category of so-called off-label-prescription, that is, use not according to instructions. Unfortunately, such inhalations are used quite widely, although their effectiveness is very low, since when it comes into contact with the mucous membrane, Eufillin has virtually no significant effect. After all, to achieve therapeutic effect the drug must get into the blood.
In such situations, relaxation of the bronchi and removal of mucus occurs due to the fact that water vapor enters the respiratory tract during inhalation. That is, inhalation with Eufillin is comparable in effectiveness to inhalation with plain water. Therefore, in order to treat obstructive bronchitis or relieve an attack of suffocation, it is not recommended to use inhalations with Eufillin.
Electrophoresis with Eufillin (infants, children, adults)
Electrophoresis with Eufillin in people of any age is carried out to relieve muscle hypertonicity, reduce intracranial pressure, treat hip dysplasia, osteochondrosis and arthrosis. In other words, electrophoresis with Eufillin is recommended for conditions when it is necessary to increase blood flow in a specific area. For example, with hypertonicity of the legs, Eufillin electrophoresis is carried out on lumbar region, with increased intracranial pressure or cerebrovascular insufficiency - on the cervical vertebrae, etc. This physiotherapeutic procedure allows you to create a concentration of the drug directly in the affected tissues, due to which it acts locally without causing systemic effects. It is precisely due to the absence of these systemic effects that electrophoresis with Eufillin can be used in
We recommend reading
Fusel oils in moonshine and other alcoholic beverages: influence, benefits, harm and purification
Functional projections of zodiac signs What can be said about vector projection signs
Degas E. “Blue Dancers. Essay based on the painting by Edgar Degas “Blue Dancers Dancers in Blue”
We reflect in the RSV reimbursement of social insurance expenses for the last year Appendix 2 line 090 of the calculation of insurance premiums
