Per tablet of active substance: 40 mg caffeine and 4 mg alpha-dihydroergocriptine mesylate . Auxiliary components: magnesium stearate, lactose monohydrate, anhydrous colloidal silicon dioxide, microcrystalline cellulose.

Per 1 milliliter of solution of the active substance there are: 1 mg of caffeine, 1 mg of alpha-dihydroergocriptine mesylate. Auxiliary components: purified water, ethanol , , citric acid.

Release form (detailed description)

• Round, flat pills. The edges are beveled. Color white. On front side risk tablets, on the back side the name of the drug in Latin (Vasobral). There are 10 tablets in a blister. One and three blisters per pack.
• Drops oral administration. Solution: 50 ml.

Pharmacological action

Renders vasodilating effect . Lowers the threshold of fatigue, improving mental and physical abilities.

Pharmacodynamics and pharmacokinetics

Dihydrogenated derivative ergot stimulates serotonin and dopamine receptors in the central nervous system by blocking adrenergic receptors (alpha1-, alpha2-) in vascular smooth muscle cells. After several doses of the drug, aggregation decreases significantly. Metabolic processes and blood circulation in the brain improve. Brain tissue becomes more resistant to.

Stimulation of the central nervous system is achieved primarily due to caffeine, which also affects the vasomotor and respiratory centers, as well as on the cerebral cortex. The feeling of fatigue decreases, performance increases.

Indications for use of Vasobral

Diseases:

Symptoms:

• decreased attention;
• insufficient production of body resources for proper physical and mental activity;
• Meniere's disease ;
• hypertensive and/or ;
• seizures (not in an advanced stage);
• labyrinthine and vestibular disorders;
• cerebrovascular insufficiency .

Contraindications

Reason for appearance adverse reactions This is explained by the fact that caffeine enhances the effects of alcohol on the body, significantly accelerating and intensifying intoxication. With regular and gross disregard for the rules for using the drug, in some cases, the occurrence of hypertensive crisis .

Use of medication during pregnancy

The evidence-based scientific base regarding the effects of Vasobral on the fetus has not been developed. In this regard, it is not recommended to use the drug during pregnancy. In case of urgent need and with the approval of a qualified treating specialist, Vasobral can be used as a treatment for pregnant women.

Reviews for Vasobral

Numerous reviews on forums on the Internet show that the drug is quite popular among many users who, in general, characterize the medicine positively. Indications for the use of the drug, in particular, with lack of attention, absent-mindedness and physical/mental fatigue occur in large quantity people. Vasobral copes excellently with its main function– raising the tone and vigor of the patient being treated.

It is not advisable to use Vasobral when taken by children. Feedback from parents in this case is both positive and negative character. Some analogues of the drug exhibit similar effects on the human body, but their symptoms and indications for use often differ.

Vasobral price, where to buy

Price per Vasobral tablets in Russia it fluctuates around 900-950 rubles. Price in Ukraine – 400-550 hryvnia.

Buy Vasobral in drops on the territory of the Russian Federation it is possible in almost any pharmacy. You can buy the solution in Moscow from 520 rubles, in the Ozerki pharmacy - for 500 rubles. Cost in others retail networks set at approximately the same level.

• Online pharmacies in Russia Russia

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I collected 30 tablets.Chiesi Farmaceutici [Chiesi Pharmaceuticals]

Europharm * 4% discount using promo code medside11

Vaso collected 30 tablets Chiesi Pharmaceuticals S.p.A./Pharmstandard-L

Pharmacy Dialog * discount 100 rub. by promo code medside(for orders over 1000 rub.)

Vasobral (tab. No. 30)

Pharmacy IFC

• Vasobral Chiesi S.A., France

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Author-compiler:- pharmacist, medical journalist Speciality: Pharmacist

Education: Graduated from Rivne State Basic medical college majoring in Pharmacy. Graduated from Vinnitsa State Medical University named after. M.I. Pirogov and internship at his base.

Experience: From 2003 to 2013, she worked as a pharmacist and manager of a pharmacy kiosk. She was awarded diplomas and decorations for many years of conscientious work. Articles on medical topics were published in local publications (newspapers) and on various Internet portals.

PLEASE NOTE! Information about medications on the site is for reference and general information, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medications in the course of treatment. Before use medicinal product Be sure to consult your doctor if you take Vasobral.

Anastasia | 12:48 | 16.04.2019

My cerebral circulation is impaired, so I constantly suffer from dizziness and headaches. This is already a classic set of symptoms for my problem. But besides this mental state I also suffer: concentration is impaired, I sleep restlessly, I have no strength. State of mind apathetic, lethargic, I take offense at my family for no reason. Only Vasobral helped to overcome these symptoms and feel healthy and cheerful. I took it for three months on the doctor’s advice, my sleep also improved, after about a month I noticed that the headaches were going away, I was becoming more energetic and attentive.

Olga | 14:04 | 14.03.2019

First of all, if you experience frequent headaches, migraines, memory loss, and God forbid, tinnitus, you need to go to a specialist. No one can help you better than a qualified doctor. At one time, thanks to a timely visit to a neurologist, I was diagnosed with deterioration cerebral circulation, I was immediately prescribed treatment. The doctor prescribed Vazobral, and from the first course of treatment, improvements were already noticeable. Now I take it consistently twice a year, one course (lasts two months). It has become much easier, there is no pain, the crippling migraines have passed, my head seems to have become clear, I feel like my fatigue has decreased. On the unpleasant side, at first I was periodically bothered by a rapid heartbeat, but it quickly went away, after about a week.

Katerina | 19:46 | 18.12.2018

Helped cope with constant headaches, effective, without side effects, improves mood, no shortcomings were found. After moving to a new place of work, nagging headaches became my eternal companions. Okay, if this lasted a month, it could be chalked up to bad habit, but all this lasted for about six months. The dizziness began to increase, feeling unwell, I've always been a morning person, but I just couldn't lift my head from the pillow. Relatives also noticed this and insisted on an examination. The neurologist concluded that I have problems with vascular circulation in the brain. He prescribed me to drink a glass of water and find a relaxing hobby, because it was overwork and constant stress at work that led me to illness. Vasobral acts quite gently, but effectively, all symptoms go away unnoticed, and the condition improves. My performance has also improved, I began to get enough sleep and get up normally in the morning. I signed up for a drawing course to relax. I went to the doctor after a course of vasotherapy, he said that everything was fine with me and I didn’t need an additional course. I took the tablets according to the instructions twice a day.

Valeria | 17:46 | 06.02.2018

What does "be careful" mean? In fact, your doctor should have prescribed Vasobral to you (like any other drug, especially a similar one) and this property of Vasobral is described in the instructions. Your doctor should have known this - change your doctor. It's the other way around for me high blood pressure, and Vazobral suited me perfectly for another reason, although it is not intended for this (in fact, it was prescribed to me for a different reason). And my doctor is gold! Thanks to him.

Nina | 8:29 | 06.12.2017

Lyudmila, I have been taking Vazobral for several years now and have never had any side effects. My doctor prescribes it for me to prevent strokes, and I actually feel much better when I start taking it. Check with your doctor again, but I think he did everything right.

Oksana | 9:56 | 08.09.2017

I also started taking Vasobral as prescribed by the doctor. But it all started with a headache, tinnitus, constant feeling tired, you wake up in the morning already tired. But I’m not even forty years old yet. This is a medicine that improves brain function, normalizes nervous condition. So I took a leave of absence from work, took the course and now I feel fine and have no previous symptoms.

In this article you can read the instructions for use of the drug Vasobral. Feedback from site visitors - consumers - is presented of this medicine, as well as the opinions of specialist doctors on the use of Vasobral in their practice. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Vasobral, if available structural analogues. Use for the treatment of Raynaud's disease, cerebrovascular accidents, attention and memory in adults, children, as well as during pregnancy and lactation. Interaction of the drug with alcohol.

Vasobral- combination drug. Alpha-dihydroergocryptine is a dihydrogenated ergot derivative that blocks alpha1 and alpha2 adrenergic receptors. It has a dopaminergic, serotonergic effect, reduces platelet and erythrocyte aggregation, reduces the permeability of the vascular wall, increases the number of functioning capillaries, improves blood circulation and metabolic processes in the brain, and increases the resistance of brain tissue to hypoxia.

Caffeine has a psychostimulating and analeptic effect, enhances excitation processes in the cerebral cortex - increases mental and physical performance, reduces fatigue and drowsiness, increases reflex excitability spinal cord, stimulates the respiratory and vasomotor centers, has a diuretic effect.

Compound

Alpha-dihydroergocriptine mesylate + Caffeine + excipients.

Pharmacokinetics

When taken orally, the absorption of dihydroergocriptine is accelerated in the presence of caffeine.

Indications

• decline mental activity, impaired attention and memory, impaired spatial orientation caused by age-related changes;
• cerebrovascular insufficiency (including due to cerebral atherosclerosis);
• consequences of cerebrovascular accident;
• migraine prevention;
• vestibular and labyrinthine disorders (dizziness, tinnitus, hypoacusia) of ischemic origin;
• Meniere's disease;
• retinopathy (diabetic and hypertensive);
• peripheral arterial circulation disorders (Raynaud's syndrome and disease);
• venous insufficiency.

Release forms

Pills.

Oral solution (sometimes mistakenly called drops).

Instructions for use and dosage regimen

Orally (during meals, with a small amount of liquid) 0.5-1 tablets or 2-4 ml of oral solution (1-2 dosing syringes) 2 times a day.

The duration of the course of treatment is 2-3 months; if necessary, courses of treatment can be carried out 1-2 times a year.

Side effect

• nausea;
• gastralgia;
• dyspepsia;
• dizziness;
• excitation;
• headache;
• allergic reactions;
• tachycardia;
• hypotension.

Contraindications

• increased individual sensitivity to the components of the drug.

Use during pregnancy and breastfeeding

There are no clinical data on the use of Vazobral during pregnancy and lactation. Use of the drug during breastfeeding may lead to decreased lactation.

Special instructions

Vasobral has a vasodilating effect without affecting systemic blood pressure. Prescription of Vazobral for patients with arterial hypertension does not exclude the need to use antihypertensive drugs.

The oral solution contains ethanol (alcohol).

Drug interactions

With the simultaneous administration of Vasobral and antihypertensive drugs possible development arterial hypotension. Caffeine weakens the effect of sleeping pills.

Analogs of the drug Vasobral

Structural analogues according to active substance the medicine Vasobral does not have.

Analogues pharmacological group(correctors for cerebrovascular accidents):

• Amylonosar;
• Bilobil;
• Bilobil forte;
• Bravinton;
• Breinal;
• Vero Vinpocetine;
• Vertizin;
• Vertisin Forte;
• Vincamine;
• Winpoton;
• Vinpocetine;
• Vinpocetine forte;
• Vincetin;
• Vitrum Memory;
• Gingium;
• Ginkgo Biloba;
• Ginkyo;
• Ginkum;
• Ginos;
• Dilceren;
• Cavinton;
• Cavinton forte;
• Complamin;
• Xanthinol nicotinate;
• Nilogrin;
• Nimopin;
• Nimotop;
• Nicergoline;
• Oxybral;
• Picamilon;
• picanoyl;
• Pikogam;
• Sermion;
• Stugeron;
• Tanakan;
• Telektol;
• Cellex;
• Tsinedil;
• Cinnarizine;
• Cinnarone;
• Cinnasan.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.

Vegetative-vascular dystonia (VSD) occurs due to a decrease in vascular tone, as a result of which it develops.

The disease is characterized by a number of symptoms, the manifestation of which can be reduced by specially selected drugs, including drugs that strengthen blood vessels and normalize their oxygen metabolism. Such a drug is the drug Vasobral, which is successfully used for treatment of VSD and migraines.

VSD is characterized huge number various symptoms, there are more than a hundred different manifestations of this disease. Features of vegetative-vascular dystonia are that symptoms appear suddenly, so-called attacks or crises. Common symptoms:

• dizziness;
• angina pectoris;
• feeling of lack of air;
• pain in the left hypochondrium;
• headache;
• tinnitus;
• psycho-emotional instability (fears, phobias).

There is only one reason for these manifestations of the disease - this is the unstable work of the vegetative system. nervous system. Instability appears suddenly. The impetus to start can be anything - from some food products to stressful situation or emotional arousal. Loss of vascular tone is accompanied by sleep disturbances, irritability and chronic fatigue.

VSD manifests itself differently in patients. For some, the frequency of attacks is so low that the disease does not interfere with normal life. Some patients note a significant deterioration in quality of life due to attacks; symptoms appear almost daily.

Every patient with VSD sooner or later faces an exacerbation of fear, phobias and panic attacks. These symptoms develop against the background vegetative crisis. More often, fears are associated with a lack of understanding of the processes that occur in the patient’s own body. Since VSD is often accompanied by pain in the heart area, fear develops heart attack and, accordingly, thanatophobia - fear of death.

Complex therapy allows you to get rid of these symptoms, however therapeutic effect achieved only with a long course of treatment.

VSD therapy

One drug will not work. With this disease, no pathologies of the cardiovascular system or internal organs, and treatment is aimed at normalizing the functioning of the patient’s autonomic system. Treatment is complex and includes:

• normalization of cerebral circulation;
• normalization blood pressure;
• strengthening the walls of blood vessels;
• normalization of psycho-emotional state;
• stress relief and.

To obtain such a complex therapeutic effect, several various drugs. Medicines with a vasodilating effect help normalize blood supply to the brain. At the same time, it is important to control the patient’s blood pressure, to normalize which they use special drugs. Medicines with vitamins (for example, Ascorutin), as well as drugs that improve metabolic processes in the brain.

Symptoms of VSD are aggravated by stress and overstrain of the nervous system. To get rid of these conditions, antidepressants, sedatives and tranquilizers are used. An important condition to normalize vegetative function is normal healthy sleep, for the improvement of which the technique is indicated sedatives and sedatives of traditional medicine.

Vitamin and mineral complexes help strengthen the nervous system and the walls of blood vessels. Regular intake of B vitamins, preparations with rutin and magnesium, which have a positive effect on nerves and blood vessels, is recommended.

Vasobral and VSD

Vasobral is one of the popular drugs for the treatment of a number neurological disorders, including VSD. The medicine is prescribed in the following cases:

• vegetative-vascular dystonia;
• migraine;
• memory and concentration disorders;
• weather sensitivity;
• cerebral circulatory disorders.

The effectiveness of the drug increases with properly selected complex treatment.

The work is based on influencing directly the central nervous system, resulting in a double effect - improving blood circulation in the brain and stimulation metabolic processes in vessels.

Thanks to the combined composition, the medicine controls vascular tone and has psychostimulant effect.

There are not many contraindications to taking the medicine - pregnancy, lactation and individual intolerance to the components of the drug.

Possible side effects

In general, the medicine is well tolerated. Taking the drug Vasobral for VSD helps to quickly improve the patient’s well-being; side effects appear in two cases - when the dosage is exceeded, and also when individual intolerance components of the drug.

The following phenomena may develop:

• decreased blood pressure;
• disorders of the gastrointestinal tract;
• headache;
• dizziness;
• weakness.

At reduced drug is prescribed with caution, since in some cases the medicine helps lower blood pressure, which can lead to a deterioration in well-being. The decrease in blood pressure when taking Vasobral is short-term. This feature provides a good therapeutic effect in the treatment of patients with hypertension. The effectiveness increases many times if Vasobral is supplemented with other medications to normalize blood pressure.

Therapy for high blood pressure is selected only by the attending physician, since the wrong combination of medications can contribute to a rapid decrease in blood pressure, which will lead to the development of a hypertensive crisis and loss of consciousness.

Combination with other drugs

Patients with hypotension should take Vasobral cautiously to avoid a further decrease in blood pressure. For hypertension, it is important to monitor treatment by a doctor, as there is a risk of a rapid decrease in blood pressure.

The medicine impairs the effectiveness of sedatives, which are often prescribed to normalize sleep in patients with VSD. If it is necessary to treat insomnia and when taking tranquilizers, antidepressants and sedatives, you should consult with your doctor about adjusting the dosage of these medications during treatment with Vasobral.

The drug is not combined with alcohol consumption. Alcoholic drinks enhance the effect of the drug, which is fraught with the development side effects. The use of Vasobral for the treatment of the consequences of alcoholism is advisable only if the patient’s condition is constantly monitored by the treating narcologist.

Release form and availability

The medicine is sold in two forms - tablets (40 pieces per package) and solution (50 ml). The drug is not cheap; the cost of the solution is slightly lower than the price of the tablets. Since the medicine is potent, it is dispensed in pharmacies only with a prescription from the attending physician. There are no problems purchasing the medicine, since it is available in all major pharmacies and pharmacy chains.

Migraine treatment

Migraine is characterized by sudden attacks which are accompanied severe pain only on one side of the head. In addition, migraines include nausea, confusion, weakness, and tinnitus.

Vasobral for migraine is used in a course to reduce the frequency of attacks. The medicine affects vascular tone and blood circulation in the brain, which reduces the frequency of attacks and reduces symptoms. It should be understood that directly during an attack, at the beginning of treatment, the medicine does not bring any relief, since it does not have an analgesic effect.

The doctor selects the treatment regimen. Usually the course lasts several months. After the body has become accustomed to the action of the drug, the medicine can be taken to relieve the attack. Symptoms are reduced by vasodilator effect caffeine composition and effects taken pills directly to the receptors responsible for cerebral vascular tone.

Vaso collected. alpha-dihydroergocriptine – dihydrogenated ergot derivative

Combined preparation containing the active ingredient alpha-dihydroergocriptine mesylate, caffeine and auxiliary components. Available in the form of tablets and solution for oral administration

Active ingredient

The active substance of the drug alpha-dihydroergocriptine is a dihydrogenated derivative of ergot. Pharmacological action - blocking alpha1- and alpha2-adrenergic receptors.

The active substance has:

• dopaminergic effect;
• serotonergic effect.

Active ingredient:

• helps reduce platelet and erythrocyte aggregation;
• helps reduce the permeability of blood vessel walls;
• activates blood circulation in the brain;
• normalizes metabolism in neurons;
• increases the number of functional capillaries;
• improves resistance to hypoxia.

Caffeine, which is part of the drug Vasobral, has:

• psychostimulating effect;
• analeptic effect.

Caffeine enhances excitation processes in the cerebral cortex, due to which, when taking the drug in recommended therapeutic doses, mental and physical performance increases, manifestations of astheno-neurotic syndrome decrease (fatigue, drowsiness, lethargy, apathy, decreased concentration, memory impairment and sleep disturbances, and etc.).

Caffeine significantly increases reflex conductivity of the spinal cord, promotes respiratory activation and stimulates vasomotor centers. Ergot alkaloids eliminate the formation of blood clots.

After the course of treatment the tone increases venous vessels, the permeability of blood flow improves, and the clumping of platelets and red blood cells is prevented.

Mild diuretic effect complements the therapeutic effect combination drug Vaso collected.

Absorption of the drug occurs half an hour after taking the dose. The elimination period is two hours, together with bile. Small amounts of ergot alkaloids are found in breast milk.

The drug reduces the manifestations of meteosensitivity and the body’s reaction to sharp jumps ambient temperature.

Symptoms of weather sensitivity:

• nausea;
• vomit;
• sleep disorders and insomnia;
• fainting.

History of creation

Neuroprotective drugs are medical supplies with an active substance that can prevent the death of neurons caused by exposure to one or any group of pathogenic factors.

The pharmacological effect of neuroprotectors is due to their ability to completely eliminate or reduce to varying degrees pathophysiological and biochemical disorders in neurons.

The creation of neuroprotectors began in the early 70s of the last century. Since that time, the list of neuroprotectors has been constantly updated and the scope of their use has expanded.

Neuroprotective drugs are the most prescribed by doctors for patients suffering from cerebrovascular insufficiency.

As a result, in most cases, with individual selection of medication, timely treatment and patient compliance with all doctor’s instructions, it is possible to prevent the development of pathological processes in brain tissue and prevent severe and irreversible consequences of neuronal damage.

The scientists' research lies in the field of studying cerebrovascular disorders and creating substances that have a minimum of side effects with a high degree of action, that is, they have a positive effect on cerebral metabolism in the brain and can normalize blood supply to the brain.

These drugs currently include vasoactive agents and dosage forms, affecting blood clotting.

The group of neuroprotectors are drugs that have different structure, a different mechanism of action and its own classification.

The drug Vasobral belongs to the group of neuroprotective combination drugs. Absorption of the active substance dihydroergocriptine goes faster and is more effective in the presence of caffeine, which is part of the drug, increasing its pharmacological effect.

The main mechanisms of action of neuroprotective drugs:

• the ability to accelerate the penetration of glucose through the blood-brain barrier;
• activation of cholinergic impulses in the central nervous system;
• acceleration of protein synthesis in neurons and red blood cells;
• increased synthesis of phospholipids in neurons;
• removal of free radicals;
• activation of higher mental functions;
• activation of cerebral microcirculation;
• inhibition of lysosomal enzymes;
• normalization of cortical-subcortical interaction, neurotransmitter disorders and reparative processes.

An important factor is that drugs in this group can be prescribed for the treatment of various pathologies of the central nervous system and used healthy people if necessary (general physical and intellectual fatigue, natural consequences aging of the body, extreme situations).

Indications for use

Vasobral is prescribed:

• with complaints of decreased mental activity and concentration;
• with memory impairment;
• at various forms violations of orientation in space, which are formed as a result age-related changes in elderly patients;
• with cerebrovascular insufficiency, including those caused by complications of cerebral atherosclerosis;
• with the consequences of disorders of cerebral blood supply to the brain;
• How preventative measure with frequent migraine attacks;
• for vestibular and labyrinthine disorders (dizziness, tinnitus, hypoacusis) of ischemic origin;
• with Meniere's disease;
• with osteochondrosis;
• for retinopathy in patients diabetes mellitus and arterial hypertension;
• for peripheral arterial circulation disorders (Raynaud's syndrome and disease);
• with venous insufficiency.

Directions for use and doses

The drug is administered orally during meals, 0.5-1 tablets or 2-4 ml of solution (1-2 dosing syringes) with a small amount of water twice a day.

At varicose veins veins, accompanied by swelling and pain, the dose of the drug is 5 mg or 20 drops of solution in three doses. The course of therapy is about four months.

The initial stage of varicose veins, accompanied by severity in lower limbs. One tablet in the morning for two to two months.

Trophic ulcers. The treatment period increases to six months.

Alcoholism. The drug is indicated for treatment alcohol addiction, as noted positive influence active substance on the central nervous system, blood supply to the brain, peripheral circulation. Vasobral has a calming effect. Recommended in composition complex treatment alcohol dependent persons together with other medications.

Side effects

From the gastrointestinal tract:

• nausea;
• epigastric pain of varying intensity;
• dyspepsia.

From the central nervous system:

• dizziness;
• excitation;
• headache of varying intensity;

From the cardiovascular system:

• attacks of tachycardia;
• lowering blood pressure.

People prone to allergic reactions may experience itchy skin And various manifestations allergic reactions.

Attention! Side effects when taking the drug are observed extremely rarely. According to statistics, no more than one percent of one hundred respondents reported one or another side effect. At the same time, patients suffering from arterial hypertension noted a significant improvement general condition body after a course of treatment with Vasobral.

Overdose

In case of overdose, side effects develop. Help when the dose is exceeded is to eliminate symptoms.

Interaction with ethanol. You should not drink alcohol while taking Vazobral, as the likelihood of developing side effects of the drug and deterioration of the patient’s general standing increases.

Often, simultaneous use leads to the development of a migraine attack or hypertensive crisis in the patient. These pathological reactions are explained by the fact that caffeine can significantly accelerate the penetration of alcohol from the bloodstream into the brain tissue, while increasing the state of intoxication.

Having a psychostimulant effect, caffeine in combination with alcohol can lead to serious consequences for health.

Contraindications to the use of the drug

Vasobral is contraindicated:

• in case of individual intolerance to the components of the drug;
• during pregnancy and breastfeeding (there is no reliable clinical data on safety, but it is known that Vasobral reduces the amount of breast milk in a nursing mother in some cases).

Special instructions for doctors and patients

The drug promotes vasodilation, but has no effect on systemic blood pressure.

Patients with arterial hypertension. For patients suffering from arterial hypertension and taking Vasobral, it is also necessary to take special means, lowering blood pressure.

Vasobral in the form of an oral solution contains ethanol.

Caffeine, which is part of the drug, in some cases causes insomnia and attacks of tachycardia.

Vasobral and other medications

The simultaneous use of Vasobral and antihypertensive drugs in some cases leads to the development of arterial hypotension. Caffeine, which is part of Vazobral, can weaken the effect of sleeping pills.

Note. When taking Vasobral and antihypertensive drugs possible sharp decline blood pressure, which leads to loss of consciousness. Therefore, before use, it is necessary to consult your doctor in order to select the optimal therapeutic dose of the drug to reduce blood pressure.

The combined use of Vasobral and Mexidol is permitted; moreover, the high therapeutic effect of the combination of these drugs has been clinically proven.

Important! Self-medication is unacceptable. Without knowing the composition of the drug and its pharmacological action If you take several medications at the same time, you can reduce the effect of all the medications you are taking. An overdose is also possible due to the mutual enhancement of similar or similar active substances.

Safety and high efficiency of the drug. Clinical studies

Chronic cerebral circulatory disorders are a serious problem in neurology.

Clinical studies drug Vasobral at the Department of Neurology and Neurosurgery (Medical Faculty of the State Medical University Roszdrav).

Cerebrovascular disorders are widespread and have a strong tendency to progress pathological process, are manifested by a variety of symptoms, which, in many cases, makes it difficult to timely and correct positioning diagnosis and selection of adequate treatment that gives good effect.

Doctors are faced with the task of removing the risk of repeated episodes of acute cerebral ischemia and avoiding ischemic stroke and therapeutic measures, allowing, to one degree or another, to eliminate the rapid progression of cerebral vascular damage. Ultimately, the goal of therapy is to improve the quality of life of patients by eliminating symptoms.

Today, to prevent ischemic stroke, doctors prescribe the following treatment and preventive measures:

• constant monitoring of blood pressure;
• glycemic control;
• the patient is taking special antiplatelet drugs;
• maintaining a balanced diet;
• adequate physical activity.

Compliance with all these measures does not always prevent the onset of chronic cerebral ischemia, therefore research and search for new ones are constantly being conducted all over the world. therapeutic approaches for the treatment of patients with cerebrovascular accidents.

The results of clinical studies of the drug Vasobral showed a good effect in treating patients with chronic cerebrovascular disorders ( chronic ischemia brain, vertebrobasilar insufficiency).

The use of the drug Vasobral in the form of a solution (orally) showed more quick effect compared to the tablet form. A high therapeutic effect was shown by the administration of high daily doses, namely: 4 ml twice a day or 1 tablet twice a day, that is, eight mg per day.

Patients tolerated Vasobral well both in tablets and in solution; no significant side effects were observed. Undesirable side effects were mild and short-term in nature, and no dose-dependent nature was noted. On the positive side the drug Vasobral is the possibility of its inclusion in the composition complex therapy.

Vascular and migraine. Clinical studies, the results of which were published in the Neurology supplement (magazine Consilium Medicum, 2010, No. 1)

The prevalence of migraine headaches is up to 15%. Women suffer from migraines three times more often than men. Negative factor is that the peak of the disease occurs at 35-45 years (the most working age). Statistics for Russian Federation– About 22 million people complain of regularly recurring migraine attacks.

Clinical studies have shown an improvement in the quality of life after four months of therapy in patients taking the drug as part of complex treatment measures.

Correlation analysis did not reveal any dependence of the drug effect on the age of patients, the frequency of migraine attacks, the duration of the disease, the intensity of pain during an attack, the initial level of depression, the degree of impairment of daily physical and intellectual activity additional therapeutic measures.

A direct correlation was found between the effect of the drug and initially more vivid symptoms asthenic manifestations(decreased general condition of the body, fatigue).

Vasobral (oral) was well tolerated by the study subjects.

The frequency of side effects was:

• 26.7% of the respondents noted side effects –
• various allergic reactions – 3.3%;
• difficulty falling asleep – 16.7%);
• decrease in blood pressure – 3.3%;
• gastralgia – 3.3%.

Allergies occurred seven days from the start of taking the drug in one patient from the entire control group and went away after prescription antihistamine(reception within five days). Allergic reaction did not return after stopping the antihistamine.

A decrease in blood pressure occurred in the second or third week of treatment.

Gastralgia – second third week of treatment.

Side effects were not pronounced and went away on their own, without requiring medical assistance.

Disturbances in falling asleep developed in the second or third week of treatment, but did not cause a deterioration in the general condition during the day.

Conclusion: side effects were short-term in nature, were not pronounced and did not require discontinuation of the drug.

As a result clinical trials the following conclusion was made:

Vasobral at a dose of four mg twice a day as part of complex treatment and prophylactic measures for patients with migraine attacks significantly reduced the patients' intake of analgesics and reduced the number of attacks. In addition to Vasobral, the patients took antidepressants and muscle relaxants.

It was noted that the symptoms of various autonomic disorders, and the quality of life has improved.

Attention! From two control groups best results showed the group taking Vasobral in comparison with patients taking only antidepressants and muscle relaxants. The treatment algorithm, which included taking Vasobral eight mg per day, was called the most optimal. The study participants showed good tolerability of the drug and no side effects. The analysis of the pharmacological action of the drug Vasobral in clinical trials proves the feasibility of including it in complex therapy. First of all, this concerns patients with astheno-neurotic syndrome.

Vasobral is easy to use, has good tolerability, high therapeutic efficacy, and an acceptable safety profile, therefore it can be recommended for the treatment of patients in neurological practice as a means of complex treatment and prophylactic therapy for migraine attacks that occur without an aura.

Where is Vasobral approved?

The use of the drug is not prohibited in European countries. Vasobral is allowed in sports ( rehabilitation period after psycho-emotional and active physical activity).

Analogues

Vasobral has no structural analogues (based on the active substance alpha-dihydroergocriptine mesylate).

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Many people are interested in how Vazobral works with low blood pressure? This combination drug is not able to increase low performance Blood pressure, on the contrary, it lowers high blood pressure, which thereby allows its use for the treatment of hypertension. The benefit of the medication is that Vazobral effectively increases physical and mental performance, and also eliminates drowsiness and lethargy.

What kind of drug?

The main purpose of the drug "Vazobral" is to improve cerebral circulation. The drug contains the following components:

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• caffeine;
• alpha-dihydroergocriptine;
• ethanol;
• food additive E330;
• glycerol;
• distilled water.

The action of the drug is aimed at improving blood circulation in the brain.

Medicine affects platelets and prevents red blood cells from sticking together. In the process of using Vasobral, capillary permeability can be normalized, which makes it possible to use it for varicose veins. "Vasobral" is considered an excellent prevention of migraine attacks and effective means to improve well-being during sudden temperature changes, changes in weather conditions and time zones. As a result of treatment with the drug "Vazobral", normalization of blood circulation and oxygen supply to the brain is observed.

Medicinal substances "Vasobral" are absorbed half an hour after dose taken. They are excreted along with bile after 2 hours. Small amounts of the substance may be found in breast milk. It is allowed to take the described medication only after consultation with a specialized physician and in the dosages prescribed by him.

Indications

Vasobral is prescribed for the treatment of the following pathologies:

• increase in fluid in the cavity of the inner ear;
• Raynaud's syndrome;
• tinnitus;
• violation of orientation in space;
• memory impairment;
• dizziness;
• pathologies of the eye retina;
• decreased mental abilities;
• violation of peripheral arterial circulation;
• weather sensitivity;
• increased sensitivity to temperature changes;
• intracranial pressure;
• unsteady gait.

The medication reduces high blood pressure.

In addition, you can take Vasobral for VSD (vegetative-vascular dystonia). This pathology occurs after undergoing severe stress, acute inflammatory process or neurotic disorder. The medication is used as a complex treatment and helps strengthen vascular walls brain, as well as their enrichment with oxygen. The described blood pressure medication is often used, the indicators of which consistently remain at 140/90. In this case, the medication gradually reduces the pressure to its normal levels.

How to take Vazobral for problems with blood pressure?

The dosage and duration of the therapeutic course are prescribed by the doctor individually for each patient, depending on the indications and the general condition of the patient. Vasobral is usually prescribed 2-4 ml 2 times a day. Take the medicine during the meal with a small amount of water. The duration of treatment varies from 60 to 90 days. In tablet form, the medication is consumed in ½-2 tablets. per day.