Children's Sinekod: application features, dosage, analogues, review of reviews about the treatment of children. Sinekod is an effective remedy for dry, hysterical cough.

Brief instructions according to the use of Sinekod in drops and syrup, it is used:

  • For severe dry cough of any etiology
  • When e
  • Before bronchoscopy and other surgical interventions
  • For cough suppression before and after surgery

Main active active substance the drug Sinekod is Butamirate, which has an antitussive effect central action. It has anti-inflammatory, expectorant and bronchodilator properties, has direct action on the cough center, improves blood oxygenation and spirometry, reducing resistance respiratory tract. It is not an opium alkaloid, neither pharmacologically nor chemically.

Key Benefits

It is important that Sinekod for children can be used with early age in drops from 2 months, in syrup from 3 years, taken before meals 4 times a day.

Sinekod - drops and syrup - official instructions for use

Name: Sinecode
Dosage form: drops and syrup for oral administration
Dosage: 20 ml drops, 100 and 200 ml syrup.
International Non-Proprietary Name: Butamirat
Group : Treatments respiratory diseases, to relieve cough and cold symptoms
Pharmaceutical group: Antitussives
Price: Sinekod drops - on average in pharmacies 320-350 rubles, syrup 100 ml. — 200 rubles, 200 ml. — 330 rub.
Analogues of Sinecode: Omnitus (tablets, syrup).

Compound

  • Sinekod syrup, the instructions for use indicate that it is a clear, colorless liquid with a vanilla odor.
    1 ml. syrup contains 1.5 mg butamirate citrate
    Excipients: sodium hydroxide, sodium saccharinate, sorbitol solution 70%, benzoic acid, glycerol, vanillin, ethanol 96%, water.
  • Sinekod drops, the instructions for use indicate that this is a transparent liquid with a yellowish tint for oral administration.
    1 ml. drops contains 5 mg. butamirate citrate
    Excipients: benzoic acid, sorbitol solution 70%, glycerol, vanillin, sodium saccharinate, ethanol 96%, water, sodium hydroxide.

Pharmacological properties

Sinecode is an effective antitussive drug that affects the cough center, does not belong to the opium alkaloids, facilitates breathing, has a bronchodilator effect, improves blood oxygenation and spirometry. When taken orally, Butamirate is completely and quickly absorbed. The maximum concentration after taking 150 mg of the drug is achieved in plasma on average after an hour and a half and is 6.4 mcg/ml. In the blood, the hydrolysis of butamirate begins initially to diethylaminoethoxy-ethanol and 2-phenylbutyric acid, which have antitussive activity. These metabolites are almost maximally bound to plasma proteins up to 95%, which explains long period half-life from plasma, which is 6 hours. Excretion of metabolites occurs mainly in the urine.

Indications

Suppression of cough during whooping cough, treatment of dry cough of various origins, symptomatic suppression of cough before bronchoscopy, before and after surgical interventions.

Contraindications

  • Pregnancy, lactation period
  • For drops - neonatal period (up to 2 months)
  • For syrup - for children under 3 years old
  • Hypersensitivity to the components included in the drug

Category of action on the fetus

Since pregnant women have controlled clinical trials has not been conducted, the use of Sinecode in the first trimester of pregnancy is contraindicated; in the second and third trimesters of pregnancy, its use is possible, taking into account the potential risk to the fetus and benefits to the mother. There is also no data on the excretion of butamirate in breast milk, so the use of Sinecod during lactation is not recommended. In animal studies, no negative effects on the fetus were found.

Directions for use and dosage

Both syrup and Sinecod drops must be taken before meals. Before using drops for children under 2 years of age, consult a doctor. The measuring cap that comes with the syrup should be used when determining the dose of the drug; it must be washed and dried after each use. Cough persisting for more than a week requires consultation with a doctor. The table shows the dosage of Sinekod drops and syrup for children depending on age and for adult patients.

Side effect

Sinekod very rarely causes the following side effects:

  • From the gastrointestinal tract - diarrhea, nausea
  • From the side of the central nervous system - drowsiness, dizziness
  • Allergic reactions
  • From the outside skin- exanthema

Overdose

Vomiting, drowsiness, diarrhea, nausea, decreased blood pressure, dizziness. There is no specific antidote. Treatment for overdose - intake activated carbon, gastric lavage, symptomatic therapy aimed at maintaining and preserving vital important functions body.

Special instructions

Since butamirate suppresses cough, expectorants should not be taken at the same time, as this may lead to accumulation of mucus in the respiratory tract, causing bronchospasm or respiratory tract infection.

Patients with diabetes mellitus Sinekod can be used, since it contains saccharin and sorbitol as sweetening additives. Caution must be exercised when operating machinery and driving vehicles, as the drug causes drowsiness.

Interaction with other drugs: Not described.
Shelf life and storage conditions: Shelf life: 5 years. Sinekod must be stored at a temperature below 30C, out of the reach of children.
Manufacturer: Name - Novartis Consumer Health SA, Switzerland, address: Re de Letraz PO Box 269.

If you have used Sinekod for children or adults, your review of the drug may be of interest to our readers; you can leave it in the comments.

Sinekod cough syrup has universal action. Included in main component, butamirate, can cope with various coughs. The medication is prescribed by therapists and pediatricians to eliminate dry and wet cough. Due to universal property, the drug has gained great popularity in the field of pharmaceuticals and medicine. It is worth using medicinal syrup on the recommendation of a specialist; the dosage may vary depending on the stage and type of pathology.

The syrup is used for pathologies of the bronchopulmonary system. Helps relieve inflammation, has a direct effect on the cough center, and has an expectorant and bronchodilator effect.

Sinekod is considered universal remedy, can be prescribed for dry, debilitating cough and wet cough with the presence of mucus of various etiologies. The effect of the drug varies. When coughing wetly, it helps to liquefy mucus and quickly remove it from the organs. respiratory system, stops attacks.

During coughing with difficulty removing mucus, it promotes dilation of the bronchi, enhances the expectorant effect by thinning the mucus. The attacks begin to be mild in nature, without pain and then disappear completely.

Due to listed properties, the medication can be prescribed for the following pathologies:

  • dry wet cough of various etiologies;
  • coughing attacks associated with the presence of whooping cough, pneumonia, bronchitis;
  • preparatory, postoperative therapy aimed at suppressing cough before or after surgery.

Therapists have different opinions about the appointment of Sinekod during wet cough. Many experts warn: with means such as Sinecod syrup, it is impossible to cure the pathology associated with wet cough. It dulls the removal of sputum, prevents the cleansing of the bronchopulmonary system and, accordingly, does not relieve the main problem and cause of inflammation - the presence of mucus in the organs.

It is worth taking the medication primarily for dry, debilitating coughs that lead to pain and do not help remove mucus. Nonproductive cough does not bring the desired alleviating effect and does not contribute to recovery, it irritates the mucous membrane of the upper respiratory tract, so it must be stopped.

What is the effect based on?

People often do not understand how a medication can simultaneously cope with two different tasks, for example, be used for dry and wet coughs, which have completely different symptoms and the reason.

The effect of drugs such as Sinekod is to stop the activity of the cough center in the brain, which leads to the relief of bronchospasm and, consequently, the absence of a cough reflex.

In simple words, syrup, when consumed orally, has a direct effect on a certain area in the cerebral cortex, which is responsible for transmitting a signal to the bronchi about the need for a cough reflex. As a result, the signal does not reach the organs of the respiratory system and is stopped, the patient stops coughing.

In addition to the direct central effect against cough, Sinekod has a number of other properties:

  • saturates the blood with oxygen;
  • reduces airway resistance;
  • relaxes the bronchi and expands their lumen.

Pay attention! The medication is not able to fight the cause of the pathology; it only has an antitussive effect, eliminating the symptoms, and not the root of the problem.

Due to its monodirectional effect, which consists in suppressing the cough reflex, the drug is not recommended for use on its own without complex therapy. The syrup can only be used as aid when treated with other medications aimed at relieving the cause of the inflammatory process. Using Sinekod, you can eliminate the symptom, but not get rid of the cause of damage to the respiratory system, which will lead to relapse of the disease.

How much does Sinekod cost?

The cost of Sinecode varies depending on the region where the medicine is sold and the personal promotion of entrepreneurs. According to patient reviews, the syrup can be purchased through online pharmacies at a relatively budget price - 150-200 rubles. In city pharmacies, its price may vary; as a rule, it does not go beyond 200-350 rubles.

The cost also depends on the volume of the bottle. It can be 100 ml, the price is about 200 rubles, 200 ml for 350 rubles on average.

What are the contraindications?

Before using any drug, you should first read the instructions. It helps to avoid negative consequences after taking the medication. Sinekod has a small list of contraindications. It should not be taken if:

  • the woman is in the first trimester of pregnancy (however, special studies have not been conducted regarding the effect on the fetus throughout the entire period of gestation);
  • there is individual intolerance to the components of the composition;
  • the patient belongs to the pediatric group under 3 years of age;
  • There is a history of pulmonary hemorrhage.

Regarding the use of syrup during pregnancy, the manufacturer recommends replacing it with a more gentle form of the drug in the form of drops. To make sure there is no allergic reaction to the medication, it is worth conducting a simple test. The product is applied in a small amount to back side palms. If after 30 minutes there is no negative reaction in the form of hives, itching, burning and redness, the syrup can be used.

Instructions for use of Sinekod syrup and dosage

The syrup should be taken in a certain way, this is indicated in the instructions for use. When the doctor prescribes a two-time appointment, it is necessary to maintain a time interval of 12 hours. When taken three times a day – 8 hours.

For children

A dose of 5 ml and a three-time dose is prescribed for children from 3 to 6 years old. A similar three-times-a-day dose, but in a dosage of 10 ml, is prescribed for a child over 6 years of age who has not reached the age of twelve. From 12 years of age, 15 ml is prescribed, 3 times a day.

For adults

The dosage for adults, as a rule, does not differ from that prescribed for children over 12 years of age. It is 15 ml, 3 times a day.

To make it easier to dose the medicine, the manufacturer includes a measuring cup in the kit. It shows the dimensional division. After each use of the medicine, it must be rinsed thoroughly.

Side effects

The syrup should be taken only as prescribed by a doctor; it has a number of side effects, which can occur not only with an overdose, but also simply while taking the medication. The manufacturer lists the most common side effects as:

  • drowsiness (drivers should be careful at this point, as concentration may decrease significantly);
  • vomiting, nausea;
  • diarrhea;
  • loss of balance, dizziness;
  • lowering blood pressure;
  • allergic reaction in the form of skin itching.

Self-administration of Sinecode is contraindicated. An increased dosage will not lead to the best result, on the contrary, can cause a negative reaction in the body.

Analogues

Sometimes the drug Sinekod is contraindicated for the patient, then it is recommended to carry out therapy with its analogues. Antitussive drugs include inexpensive analogues Sinekod syrup. These include:

  1. Omnitus. Has the same active ingredient. It has an identical structure and helps muffle coughing attacks.
  2. Codelac Neo. Domestic product. It also has 3 release forms: syrup, drops, tablets. It is used for dry cough to relieve it.
  3. Stoptussin. A Czech-made drug, which is several times cheaper in cost than Sinekod. Its price ranges from 100 to 150 rubles. It has 3 release forms in the form of tablets, syrup and drops. Adults are most often prescribed drops or tablets. Has a pronounced anti-inflammatory effect. Numerous reviews patients report that the remedy for dry cough is less effective than its analogue.
  4. Erespal. This is a popular analogue that helps eliminate dry cough and relieve inflammation. Often used in therapy colds accompanied by a cough.

The selection of an analogue should always be carried out by a specialist, as well as the treatment of the patient. Professional help is the key to effective, fast and efficient therapy.

Composition of Sinecode and release form

The drug contains the active substance - butamirate.

  • drops,
  • syrup,
  • tablets in a dense shell.

A medicinal product intended for oral administration is produced for children, which contains 5 mg of dihydrogen citrate butamirate. In every bottle medicine 20 ml of this substance. The package contains one bottle, the number of drops for children is 1 ml.

Bottles containing 100 ml or 200 ml of the drug Sinekod are also produced, one bottle in each package. Moreover, 10 ml of syrup of such a medicinal product contains 15 mg of a substance - butamirate dihydrogen citrate.

Indications for use of Sinekod

Indications for use this drug There is such a thing as a cough of almost any origin. In this case, it is possible to use the medicine in case of cough in postoperative period time, as well as after bronchoscopy or before using this procedure. The indication for use of the drug Sinekod is whooping cough. Adult patients can take Sinecod in the form of syrup, 15 ml 4 times a day.

Before the start of surgical procedures, if Sinekod is prescribed, you must take this medication orally in the amount of twenty milligrams. Patients are prescribed to take it in drops or syrup form. If in the form of syrup, then you need to take fifteen milliliters four times a day. Before surgical intervention on the respiratory system, patients are prescribed intravenous or intramuscular injection the drug Sinekod in a dose of ten to twenty milligrams.

Patients suffering from diabetes can take Sinekod in the form of drops or in syrup, since the drug contains substances such as sorbitol and saccharin. People who suffer from such characteristics of the body as lactose intolerance should avoid taking Sinecod in tablet form, since in this case lactose is present as an additional agent. The use of the drug Sinekod is possible in combination with vitamin preparations, as well as herbal medicines. In tablet form, Sinecod is taken twice a day, in particular 10 milligrams in the morning and evening.

Sinecode for cough

This drug is intended primarily to suppress the cough effect by affecting the cough centers. Sinekod should be taken in accordance with the instructions, warning against the possibility of overdose. You can take the medicine in any form - tablets, syrup, drops. If it is prescribed in syrup form, you should take 15 ml of Sinekod four times a day. In tablet form, the medicine should be taken twice a day - morning and evening. The possibility of side effects should also be taken into account, so you should take the drug with caution if there is hypersensitivity to the drug.

The direct action of the substances that are part of the drug Sinekod contributes to the most quick elimination negative consequences of cough. First of all, it should be noted its positive effect on the human body during therapy prescribed during the presence of any colds accompanied by a cough effect. However, this remedy is not the only one for the treatment of colds, but is only intended to eliminate the symptoms of cough. It is most effective to use the drug in combination with vitamins and minerals, as well as other medications. It is important to remember that self-medication can lead to negative consequences, and therefore it is important to consult with your doctor before taking this drug. The possibility of a side effect cannot be ruled out. It is especially not recommended to take the drug if you have a history of allergies. In this case, you must first find out whether there is an allergic reaction to the components that make up the medicine. It is also important to adhere to clear doses permitted for use, since an overdose can cause consequences such as increased blood pressure, dizziness, headache, nausea, vomiting. If you have one of the listed symptoms, you must stop taking the drug, take activated charcoal, a saline laxative, and consult a doctor.

Pharmacological action of Sinekod

The drug is a remedy that has a powerful antitussive effect. However, it is not related to opium alkaloids, it has a central effect, suppressing the cough center. It should also be noted that the positive effects of using Sinecode, such as the expectorant effect, decreases after use of the drug inflammatory process.

Contraindications for use of Sinecode

The product has no clear contraindications for use, and therefore can be used to treat children in case of problems associated with the appearance of a cough effect. However, in some cases this drug may be excluded for use in hypersensitivity in relation to the substances that comprise it. This is due to individual characteristics body. Such phenomena are quite rare, however, the possibility of their manifestation cannot be completely excluded, since hypersensitivity to the drug may have negative consequences in the form of some unwanted manifestations. Phenomena such as nausea, itching, as well as rash and dizziness may occur. Special attention should be shown in relation to people prone to various kinds of allergic reactions, since the use of this drug in in rare cases may cause skin redness, rashes and other symptoms characteristic of allergy patients. It is recommended to first test the product for allergies; for this, a special skin test is performed. On inner part A small amount of the drug is applied to the forearm and left for five minutes, after which the presence or absence of an allergic reaction is detected. The duration of the test is no more than ten minutes.

Side effects

Usually, if all the proper rules for taking the drug are followed, the drug does not cause any special side effects. However, in some exceptional cases, manifestations such as itchy skin, diarrhea, nausea and dizziness. These symptoms are quite rare, but their possibility should not be excluded. Particular attention should be paid to such circumstances as correct application and avoiding drug overdose. Some patients believe that using the drug in a larger dose significantly speeds up the elimination of unpleasant symptoms diseases. If the normal dose is exceeded, the effect of the drug not only does not improve, but a negative reaction on the body is also possible. This is due to a violation normal reaction substances included in the composition of the drug.

Application of Sinecode for children

Currently, Sinekod is produced in drops, intended for oral administration by children. One milliliter of this antitussive contains 5 mg of dihydrogen citrate butamirate. Each bottle of the drug contains 20 ml of the substance. In addition, the drug contains other excipients– glycerin, sodium saccharin, 96% ethanol, vanillin, 70% sorbitol solution, benzoic acid, 30% sodium hydroxide, purified water.

Sinekod can be used by children from the age of two months. Children less than two months old are not recommended to use the drug Sinekod. At the age of two months and older, Sinekod in the form of drops can be used for treatment; from the age of three, children are allowed to use Sinekod syrup. Also, the tablet form of the drug can be used by children over twelve years of age.

It is important for adults to remember that any drug has certain contraindications and possible negative side effects. The drug Sinekod is no exception to medical practice. This medicine, like any other, also has some side effects. An overdose of the drug is especially dangerous, since in this case it manifests itself negative impact substances included in its composition, which at normal doses have an extremely positive medicinal effect.

It is necessary to take the drug Sinekod in accordance with established recommendations. It is especially advisable to use the drug before meals. For children aged two months and up to one year, it is recommended to use Sinekod in drops - 10 drops four times a day. At the age of one to three years, you can give the drug in drops of 15 drops 4 times a day. Children over three years of age can take the drug 25 drops 4 times a day. If Sinecod syrup is used, you need to use a special graduated spoon, which measures certain doses of the drug.

Children aged three to six years can take syrup in certain prescribed doses - 5 ml 3 times a day. Children from the age of twelve take Sinecod in the form of cough syrup, 15 ml 3 times a day. Children over the age of twelve can take the medicine three times a day - five milligrams in the morning, afternoon and evening.

The indicated doses should not be exceeded, since in this case negative reactions on the part of the child are possible, which is due to the characteristics of the child’s body. So the drug should be taken by children with extreme caution to prevent side effects. It is also important to consider the presence allergic reactions in a child, since allergies occur in many cases and have negative consequences.

It should be remembered that the drug Sinekod contains the active substance – butamirate. Release form - bottles with a certain dose of drops, which are recommended for use by children younger age, in particular up to three years. The use of Sinekod in drops is especially convenient for children from two months of age. Use these drops orally. For children from three years of age, the drug Sinekod is available in the form of syrup. The tablet form of the drug Sinekod is not recommended for the treatment of children under the age of twelve. Children from the age of twelve can take Sinecod tablets, which are coated with a special coating. If a child is found to be intolerant to many drugs, the possibility of intolerance to the components of the drug Sinecod should also be taken into account. It is also important to comply correct dosage of this medicine.

For children, Sinekod is useful therapeutically, as a means for treating the respiratory system, especially for suppressing cough. Also efficiency this tool noted after surgical interventions. The drug Sinekod is used to treat whooping cough.

Children under the age of one year, weighing up to eight kilograms, should be given ten drops of the drug four times a day. Children who have reached the age of twelve months to three years, whose weight does not exceed fifteen kilograms, can take the drug Sinekod four times a day, fifteen drops. Children aged three years and over can receive twenty-five drops of the drug four times a day during treatment. Sinekod syrup can be taken by children aged three to six years, with a permissible dose of 5 milliliters three times a day. Children from six to nine years old should be given ten milliliters of syrup three times a day, and patients from nine years old should be given fifteen milliliters three times a day.

Use of the drug Sinekod during pregnancy and breastfeeding

Since it is completely impossible to answer positively or negatively regarding the negative effects of the drug Sinecod, it must be taken with extreme caution, taking into account any negative consequences. To avoid many unpleasant consequences, it is necessary to exclude the use of the drug Sinekod in the first trimester of pregnancy. And also in the second and third trimesters of pregnancy, it is important to avoid taking an antitussive drug, since no effect of such a drug on the pregnant woman’s body has been detected. As for women who are breastfeeding infants, in this case there is no particular need to stop taking Sinecod if the use of the drug is important for treatment. But it should be taken into account that there are some points that require immediate cessation of taking the medicine, in particular when its use can somehow negatively affect the child’s health.

Overdose of Sinekod

If Sinekod is taken incorrectly, the following may occur: negative manifestations, such as imbalance, increased drowsiness, increased blood pressure, diarrhea, nausea, vomiting. It should be borne in mind that it is necessary to take the drug Sinecod strictly according to the instructions, without exceeding the prescribed doses. It is important not to forget that everything medicines should be stored in places inaccessible to children to avoid negative consequences. If an overdose of Sinecod does occur, you must immediately take all measures to prevent complications. In this case, treatment is carried out such as the use of adsorbents, in particular activated carbon. The doctor also prescribes a saline laxative. To maintain cardiovascular function appropriate remedies are prescribed. You should not delay the treatment of a drug overdose, as this will not only complicate further therapy and the recovery process, but can also lead to serious consequences.

Sinekod drops are a non-narcotic antitussive drug for children. The product perfectly relieves the symptoms of dry skin, painful cough, it is allowed to be used for a fairly long period of time.

Young parents should know how to use the medication correctly, the right dosage. The drug has a small list of contraindications and side effects. Before use medicinal product Be sure to consult your pediatrician and carefully read the instructions.

Pharmacological properties

Sinekod in the form of drops has a pronounced antitussive therapeutic effect, it is provided by the active components of the medicinal product for children. A positive quick result is achieved by stopping the cough center in the baby’s brain. Sinekod blocks special receptors, the bronchi do not receive the signal, which stops the coughing attack.

The drug is classified as a medicine of the central group; relief of symptoms occurs in the child’s brain. This fact determines the absence of resumption of attacks of dry cough in the baby under the influence of irritating factors until the effect of Sinekod wears off.

The medicinal product has a number of beneficial effects, in addition to the antitussive:

  • reduces the baby's airway resistance;
  • helps improve blood oxygen saturation;
  • expands the lumen of the bronchi, which facilitates the breathing process.

All of the above aspects have a beneficial effect on the baby’s breathing and increase the amount of oxygen in the lungs. More oxygen saturates tissues necessary substances, general condition the child improves significantly. The combination of therapeutic effects not only provides relief from dry cough, but also saturates the baby’s organs and tissues with oxygen, which promotes speedy recovery little patient.

During oral administration, Sinekod is completely absorbed by the intestines, the maximum therapeutic effect is noticeable an hour and a half after its use. Regular use of the medication ensures the concentration of the substance in the body at a constant level, without increasing it. Active components funds do not accumulate in children's body, cases of overdose are extremely rare. The medicine is excreted through the kidneys after a fairly quick amount of time.

Doctors and parents identify several main advantages of Sinecode in the form of drops for children, which distinguish the medication from other drugs:

  • approved for use by infants (from two months);
  • absolutely safe for the health of the baby;
  • an effective medicinal product with a rapid therapeutic effect;
  • does not contain narcotic substances;
  • normalizes the breathing process without inhibiting the respiratory center;
  • does not provide harmful influence on the gastrointestinal tract, quickly eliminated from the baby’s body;
  • is used for a long course of treatment, as it is not a narcotic drug.

Composition and release form

Sinekod drops include the main component - butamirate citrate, which has a pronounced therapeutic effect and copes with a painful dry cough in a child. Additional components:

  • sorbitol solution 70%,
  • benzoic acid,
  • sodium saccharite,
  • vanillin,
  • sodium hydroxide

Auxiliary components provide the desired consistency to the medicinal product, good taste and aroma. The product is a transparent liquid of a yellowish-greenish color for oral administration.

Sinekod in the form of drops is designed to block dry cough, which is long-lasting and painful. At the same time, the mucous membranes of the throat are inflamed and severely damaged. Sputum production does not occur, but the inflammatory process does occur. The brain perceives the process as a result of entry into the respiratory tract foreign body(sputum, dust), tries to eliminate it.

A constant cough without an actual irritant aggravates the situation and delays the healing process. Sinekod blocks the brain signal, eliminating the cause of irritation of the mucous membranes of the throat. Additionally, drugs are used that kill pathogens that caused the problem. The medicine is not addictive, quickly copes with discomfort, improves respiratory function, unlike narcotic analogues (Codelac, Codterpin and others).

Indications for use

Sinekod drops are intended to eliminate attacks of dry cough during the course of diseases:

  • discomfort during the course of respiratory tract ailments (, pleurisy, and others);
  • , acute respiratory infections, influenza;
  • suppression of coughing attacks during diagnostic manipulations of the respiratory tract;
  • suppression during surgical procedures.

For children, drops are most often used, they are convenient to use, they are allowed to be given to two-month-old children, the syrup can be used by babies from three years, and pills are only allowed from the age of six.

Contraindications

Sinekod in the form of drops is prohibited from taking in the following cases:

  • babies up to two months;
  • young mothers during lactation;
  • if available individual intolerance individual components of the medicinal product.

Important! To avoid negative consequences, be sure to consult your pediatrician before using Sinekod drops, especially for young children.

Possible side effects and overdose

In most cases, Sinekod for children is well tolerated; there are rare cases of side effects that occur due to individual intolerance to individual components of the medicinal product:

Overdose of the drug is very rare, After all, the drug is quickly eliminated from the body.

Instructions for use and dosage

Sinekod drops must be taken before meals; be sure to shake the bottle and mix its contents thoroughly. In order to measure required quantity medicinal drops To avoid overdose, prepare a tablespoon or glass in advance. Shake the bottle, turn it upside down, and drop the required amount of product into the container. Then give the baby the drug, it is allowed to wash it down with a small amount of plain water.

Sinekod affects dry cough, it It is prohibited to combine with drugs that suppress wet cough. These medications do opposite functions, when they are combined, complications are observed that are unpleasant adverse reactions. Doctors do not recommend combining Sinecod drops with other drugs aimed at relieving coughs of any etiology.

Children with diabetes are allowed to take medication only with the permission of the attending physician. There have been no negative reviews for this disease after using Sinecode.

The exact dosage is determined by the doctor, but the instructions offer an approximate treatment regimen for children:

  • from two months to a year – 10 drops four times a day;
  • from one to three years - it is allowed to give 15 drops four times a day;
  • from three to six years - give 25 drops to the child four times a day.

Older children are given the drug in the form of syrup or tablets. The specific form of treatment is determined by the doctor. If you notice any unpleasant symptoms after using Sinecode, be sure to stop taking it and consult your pediatrician about replacing the product.

Storage conditions and cost

Keep this medicine away from children and direct sun rays, the optimal storage temperature for Sinecode in the form of drops is 20 degrees Celsius, allowed temperature regime no more than 30 degrees. The shelf life of the medicinal product is no more than five years; after opening the bottle, use the product within six months.

The price of Sikod drops on the pharmacological market ranges from 360-440 rubles per 20 ml package. The specific amount depends on the city of purchase and the pharmacy chain.

Analogues of the drug

The pharmacological industry produces a lot of medications that are similar in action and composition. Among the popular analogues of Sinekod drops are:

  • Bronchoton;
  • Bronholitin sage in the form of syrup;
  • Bronchitusen Vramed syrup;
  • Bronchtsin and others.

Before changing a medicinal product, be sure to consult your doctor.

Sinekod: instructions for use and reviews

Sinekod is an antitussive drug.

Release form and composition

  • syrup (vanilla): colorless clear liquid with vanilla scent (100 and 200 ml each in dark glass bottles, 1 bottle in a cardboard pack complete with a measuring cap);
  • drops for oral administration (for children): transparent liquid, colorless or with a yellowish tint, with the smell of vanilla (20 ml in dark glass bottles, equipped with a dropper dispenser and a first-opening control system, 1 bottle in a cardboard pack).

Active substance – butamirate citrate:

  • 1 ml of syrup – 1.5 mg;
  • 1 ml drops – 5 mg.

Syrup excipients: water, benzoic acid, sodium saccharinate, glycerol, sorbitol solution 70%, ethanol 96%, vanillin, sodium hydroxide 30%.

Additional components of the drops: sorbitol solution 70%, ethanol 96%, benzoic acid, sodium saccharinate, glycerol, sodium hydroxide 30%, vanillin, water.

Pharmacological properties

Pharmacodynamics

The active component of Sinecode is butamirate, which is part of the group of centrally acting antitussives. This substance is not an opium alkaloid either from a chemical or pharmacological point of view and does not lead to addiction or dependence.

Butamirate suppresses cough by directly acting on the cough center. Sinekod is characterized by a bronchodilator (bronchodilator) effect and makes breathing easier, improving blood oxygenation (oxygen saturation) and spirometry (respiratory resistance decreases).

Pharmacokinetics

Butamirate ester is quickly and almost completely absorbed and hydrolyzed in plasma to form diethylaminoethoxyethanol and 2-phenylbutyric acid. Research regarding the relationship between food intake and absorption active substance Sinekod, were not carried out. When taking doses of 22.5–90 mg, the content of diethylaminoethoxyethanol and 2-phenylbutyric acid changes in direct proportion to the amount of the drug taken.

Butamirate is detected in the blood within 5–10 minutes after oral administration of doses of 22.5, 45, 67.5 and 90 mg. With a treatment regimen that includes taking the drug in any of the above dosages, the maximum concentration in the blood plasma is achieved within 1 hour. When a dose of 90 mg is taken orally, the butyrate content in the blood is 16.1 ng/ml.

The average plasma level of 2-phenylbutyric acid is achieved within 1.5 hours. Maximum content substances of 3052 ng/ml were noted after taking a dose of 90 mg. The average plasma concentration of diethylaminoethoxyethanol is reached within 0.67 hours with a maximum concentration of 160 ng/ml recorded after a dose of 90 mg.

Butamirate has a large volume of distribution in the range of 81–112 l (adjustment for body weight in kg must be taken into account), and is also almost completely bound to plasma proteins. 2-phenylbutyric acid is characterized by a high degree of binding to plasma proteins at all dosage levels (22.5–90 mg). On average, it varies in the range of 89.3–91.6%. Diethylaminoethoxyethanol binds to plasma proteins by 28.8–45.7%. Accurate data on whether butamirate crosses the placental barrier or into breast milk, are missing.

The rate of butamirate hydrolysis is extremely high. The 2-phenylbutyric acid formed as a result of this process is also partially metabolized through hydroxylation in the para position.

All metabolites are excreted primarily through the kidneys. Those that are acidic react mainly with glucuronic acid after conjugation in the liver. The content of 2-phenylbutyric acid conjugates in urine is significantly higher than in blood plasma. Butamirate is detected in urine within 48 hours after taking Sinecod. Over a 96-hour sampling period, the urinary excretion of this substance accounts for approximately 0.02, 0.02, 0.03 and 0.03% of the total. doses taken 22.5, 45, 67.5 and 90 mg, respectively.

Butamirate is excreted in the urine predominantly in the form of diethylaminoethoxyethanol, the level of which is significantly higher than that of unconjugated 2-phenylbutyric acid or butamirate in unchanged form.

The half-lives of butamirate, 2-phenylbutyric acid and diethylaminoethoxyethanol are 1.48–1.93, 23.26–24.42 and 2.72–2.9 hours, respectively.

Indications for use

Sinecode is used for symptomatic treatment dry cough of various etiologies: with whooping cough, during bronchoscopy and surgical interventions, if it is necessary to suppress cough in the pre- and postoperative period.

Contraindications

  • I trimester of pregnancy;
  • lactation period;
  • children up to 2 months - for drops, up to 3 years - for syrup;
  • hypersensitivity to the components of the drug.

With caution: II and III trimesters of pregnancy.

Instructions for use of Sinecode: method and dosage

The drug must be taken orally before meals.

  • children 3–6 years old – 5 ml 3 times a day;
  • children 6–12 years old – 10 ml 3 times a day;
  • adolescents 12–18 years old – 15 ml 3 times a day;
  • adults – 15 ml 4 times a day.

For ease of dosing, a measuring cap is included with the bottle. It should be washed and dried after each use.

  • 2–12 months – 10 drops 4 times a day;
  • 1–3 years – 15 drops 4 times a day;
  • over 3 years – 25 drops 4 times a day.

The duration of therapy is no more than 7 days.

If treatment is necessary for children under 2 years of age, consult a doctor.

Side effects

The drug is generally well tolerated. In rare cases (>1/10,000,<1/1000) возникают следующие побочные эффекты:

  • from the central nervous system: drowsiness, dizziness;
  • from the digestive system: diarrhea, nausea;
  • from the skin: exanthema;
  • other: allergic reactions.

Overdose

Symptoms of overdose are: nausea, vomiting, drowsiness, diarrhea, dizziness, a sharp decrease in blood pressure. There is no specific antidote. Treatment of overdose consists of gastric lavage, the administration of activated charcoal and therapy that supports vital body functions.

Special instructions

During treatment, expectorants should not be taken, as this can lead to accumulation of mucus in the respiratory tract and, as a result, the development of respiratory tract infections and bronchospasm.

In the form of syrup, Sinecod can be taken by patients with diabetes mellitus, since it contains saccharin and sorbitol as sweeteners.

According to the instructions, Sinekod may cause drowsiness, which should be taken into account by vehicle drivers and patients employed in potentially hazardous industries associated with increased concentration.

Use during pregnancy and lactation

Reliable clinical studies of the safety and effectiveness of Sinecode for pregnant women have not been conducted, therefore prescribing the drug in the first trimester of pregnancy is not recommended. In the second and third trimesters, the use of Sinecod is allowed if the benefit to the mother outweighs the potential risk to the fetus.

Since there is no data on the excretion of butamirate in breast milk, taking the drug during lactation is undesirable.

Animal studies have not revealed any toxic effects of butamirate on the fetus.

Use in childhood

For children, Sinekod is contraindicated: under the age of 2 months - in the form of drops, up to 3 years - in the form of syrup.

Drug interactions

No information available.

Analogues

Analogs of Sinecode are: Codelac Neo, Omnitus, Erespal, Stoptussin, Libexin, Fluditek, Ascoril, Panatus Forte.

Terms and conditions of storage

Store at temperatures up to 30 °C out of the reach of children.

Shelf life – 5 years.