Prednisolone is a semi-synthetic glucocorticoid drug based on hydrocortisone. That is, it is a product with a high degree of biological activity, which allows the use of Prednisolone injections in clinical situations. For example, when providing immediate assistance in emergency conditions.

Antiallergic, anti-inflammatory, immunosuppressive effect, the ability to increase the sensitivity of beta-adrenergic receptors (these are proteins of the outer cell membrane that recognize and bind synthetic analogues of catecholamines with adrenaline and norepinephrine) to endogenous catecholamines (that is, active substances that perform the function of chemical “control” molecules (neurohormones) ) and mediators in intercellular interactions) are the main functions of the drug Prednisolone. Injection ampoules are available in 25 mg volumes.

Emergency conditions, such as acute allergic reactions, thyrotoxic crisis, status asthmaticus in bronchial asthma, shock that is not amenable to standard therapy (surgical, burn, toxic or anaphylactic, traumatic or cardiogenic), acute renal or liver failure, acute failure adrenal glands are an indication for the use of the drug Prednisolone.

Injections are also prescribed for rheumatic diseases (rheumatoid arthritis or systemic lupus erythematosus), acute hepatitis and cirrhosis of the liver, bronchial asthma, as well as to reduce inflammatory processes and prevent the appearance of cicatricial narrowing of tissues and blood vessels in case of poisoning with cauterizing liquids.

The dosage and duration of treatment is determined by the doctor individually, depending on the severity of the disease and the indications for the drug Prednisolone. The injections are administered intravenously through droppers (first as a stream, then as a drip) or intramuscularly if intravenous administration is not possible. After the acute condition has been relieved, Prednisolone tablets are prescribed for oral administration. In this case, the dosage is gradually reduced. If the course of treatment is long, then therapy should not be stopped suddenly.

This drug is effective, but it has quite a few contraindications and side effects. First, about the contraindications of Prednisolone. Injections are not used even vital signs if there is intolerance or hypersensitivity to the constituent components. The drug should be prescribed with caution for such ailments as recent or existing infectious diseases of a viral nature, gastrointestinal diseases, the vaccination period (as well as eight weeks before and two weeks after vaccination), immunodeficiency conditions.

In case of cardiovascular, endocrine diseases, severe chronic liver or kidney failure, systemic osteoporosis, Prednisolone should also be prescribed with caution. Injections during pregnancy, especially in the first trimester, as well as for children during the growth period, are used only according to vital signs and strictly under the supervision of the attending physician. If the drug is prescribed during lactation, it is recommended to stop breastfeeding.

Among the side effects of Prednisolone are a decrease in the body's ability to use glucose as an energy source, suppression of adrenal function, steroid diabetes mellitus, increased intracranial pressure, steroid duodenal and gastric ulcers, increased blood pressure, bradycardia (sometimes to cardiac arrest), increased calcium excretion, sexual retardation development in children, trophic changes in the cornea. And these are not all side effects. You should definitely read the complete list in the instructions for use of the drug Prednisolone.

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Prednisolone

Compound

Composition of Prednisolone in ampoules: active substance at a concentration of 30 mg/ml, as well as sodium pyrosulfate (additive E223), disodium edetate, nicotinamide, sodium hydroxide, water for injection.

Composition of Prednisolone tablets: 1 or 5 mg of active substance, colloidal silicon dioxide, magnesium stearate, stearic acid, starch (potato and corn), talc, lactose monohydrate.

Prednisolone ointment contains 0.05 g of active substance, soft white paraffin, glycerin, stearic acid, methyl and propyl parahydroxybenzoate, Cremophor A25 and A6, purified water.

Release form

• Solution for intravenous and intramuscular administration 30 mg/ml 1 ml; 15 mg/ml 2 ml.
• Tablets 1 and 5 mg.
• Ointment for external therapy 0.5% (ATC code - D07AA03).
• Eye drops 0.5% (ATC code - S01BA04).

Pharmacological action

Pharmacological group: Corticosteroids (drug group - I, this means that prednisolone is a weakly active GCS).

Prednisolone - hormonal or not?

Prednisolone is hormonal drug for local and systemic use with medium duration of action.

It is a dehydrated analogue of the hormone hydrocortisone produced by the adrenal cortex. Its activity is four times higher than the activity of hydrocortisone.

Prevents the development of an allergic reaction (if the reaction has already begun, it stops it), suppresses the activity of the immune system, relieves inflammation, increases the sensitivity of β2-adrenergic receptors to endogenous catecholamines, and has an anti-shock effect.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics: Prednisolone - what is it?

The mechanism of action of Prednisolone is associated with its ability to interact with certain intracellular (cytoplasmic) receptors. These receptors are found in all tissues of the body, but most of them are in the liver.

As a result of this interaction, complexes are formed that induce the synthesis of proteins (including enzymes that regulate vital intracellular processes).

Acts at all stages of development of the inflammatory process: suppresses the synthesis of Pg at the level of arachidonic acid, and also prevents the formation of pro-inflammatory cytokines - IFN-β and IFN-γ, IL-1, TNF, neopterin; increases the resistance of plasma membranes to damaging factors.

It affects the metabolism of lipids and proteins, and also, to a slightly lesser extent, the exchange of water and electrolytes.

The immunosuppressive effect is realized due to the ability of the drug to cause involution of lymphoid tissue, inhibit the proliferation of lymphocytes, the migration of B cells, and the interaction of B and T lymphocytes, inhibit the release of IFN-γ, IL-1 and IL-2 from macrophages and lymphocytes, reduce the formation antibodies.

Inhibition of the allergic reaction is carried out by reducing the secretion and synthesis of allergic mediators, reducing the number of circulating basophilic leukocytes, suppressing the release of histamine from sensitized mast cells and basophilic leukocytes, suppressing the development of connective and lymphoid tissue, reducing the number of mast cells, B- and T-lymphocytes, reducing sensitivity of T-effectors to allergy mediators, suppression of antibody formation, changes in the immune response.

Inhibits the synthesis and secretion of corticotropin and, secondarily, endogenous corticosteroids.

When applied externally, it relieves inflammation, inhibits the development of an allergic reaction, relieves itching and inflammation, reduces exudation, and suppresses the activity of the immune system in relation to type III-IV hypersensitivity reactions.

Pharmacokinetics

After taking the tablet, it is quickly and completely absorbed from the gastrointestinal tract. TSmax - from 60 to 90 minutes. Up to 90% of the administered dose of prednisolone is bound to plasma proteins.

The substance undergoes biotransformation in the liver. From 80 to 90% of metabolic products are excreted in urine and bile, about 20% of the dose is eliminated in its pure form. T1/2 - from 2 to 4 hours.

Indications for use of Prednisolone

What are the tablets and injection solution for?

Systemic use is advisable for:

• allergic diseases (including food or drug allergies, toxicoderma, serum sickness, atopic/ contact dermatitis, hay fever, allergic rhinitis, urticaria, Stevens-Johnson syndrome, Quincke's edema);
• minor chorea, rheumatic fever, rheumatic carditis;
• acute and chronic diseases that are accompanied by inflammation in the joints and periarticular tissue (synovitis, nonspecific tenosynovitis, seronegative spondyloarthritis, epicondylitis, osteoarthritis (including post-traumatic), etc.);
• diffuse connective tissue diseases;
• multiple sclerosis;
• status asthmaticus and asthma;
• lung cancer (the drug is prescribed in combination with cytostatics);
• interstitial diseases of the lung tissue (fibrosis, acute alveolitis, sarcoidosis, etc.);
• eosinophilic and aspiration pneumonia, tuberculous meningitis, pulmonary tuberculosis (as an addition to specific therapy);
• primary and secondary hypocortisolism (including after adrenalectomy);
• congenital adrenal hyperplasia (CAH) or dysfunction of their cortex;
• granulomatous thyroiditis;
• autoimmune diseases;
• hepatitis;
• inflammatory diseases Gastrointestinal tract;
• hypoglycemic conditions;
• nephrotic syndrome;
• diseases of the hematopoietic organs and blood (leukemia, anemia and diseases associated with damage to the hemostatic system);
• cerebral edema (post-radiation, developing with a tumor, after surgery or trauma; the annotation and Vidal reference book indicate that for cerebral edema, treatment begins with parenteral forms of the drug);
• autoimmune and other skin diseases (including Dühring's disease, psoriasis, eczema, pemphigus, Lyell's syndrome, exfoliative dermatitis);
• eye diseases (including autoimmune and allergic; including uveitis, allergic ulcerative keratitis, allergic conjunctivitis, sympathetic ophthalmia, choroiditis, iridocyclitis, non-purulent keratitis, etc.);
• hypercalcemia developing against the background of cancer.

Indications for the use of injections are emergency conditions, for example, acute attack food allergies or anaphylactic shock. After several days of parenteral use, the patient is usually transferred to the tablet form of Prednisolone.

Indications for the use of tablets are chronic and severe pathologies (for example, bronchial asthma).

Prednisolone solution and tablets are also used to prevent transplant rejection and relieve nausea/vomiting in patients receiving cytostatics.

Prednisolone ointment: why and when is external use of the drug indicated?

As an external agent, prednisolone is used for allergies and for the treatment of inflammatory skin diseases of non-microbial etiology. Indications for use of the ointment:

• limited neurodermatitis;
• dermatitis (contact, allergic and atopic);
• discoid lupus erythematosus;
• psoriasis;
• eczema;
• erythroderma;
• toxicoderma;
• hives.

Prednisolone: ​​what are eye drops prescribed for?

Eye drops are prescribed to relieve inflammation of a non-infectious nature affecting the anterior segment of the eye, as well as inflammation that develops after an eye injury or ophthalmic surgery.

Local use of Prednisolone is justified for the following eye diseases:

• iridocyclitis;
• uveitis;
• iritis;
• allergic conjunctivitis;
• keratitis (in particular, discoid and parenchymal; in cases where the epithelial tissue cornea);
• scleritis;
• episcleritis;
• blepharitis;
• blepharoconjunctivitis;
• sympathetic ophthalmia.

Contraindications

If systemic use of the drug is necessary for health reasons, the only contraindication may be intolerance to one or more of its constituent components.

For patients with severe infectious diseases, Prednisolone tablets and injections are prescribed only against the background of specific therapy.

Contraindications to intra-articular administration of the drug are:

• pathological bleeding (due to the use of anticoagulants or endogenous);
• pyogenic arthritis and periarticular infections (including a history);
• transarticular bone fracture;
• systemic infections;
• “dry” joint (no signs of inflammation in the joint: for example, with osteoarthritis without signs of inflammation of the synovial membrane);
• severe joint deformity, bone destruction or periarticular osteoporosis;
• joint instability developed due to arthritis;
• aseptic necrosis of the epiphyses of the bones that form the joint;
• pregnancy.

On the skin Prednisolone should not be used for:

• mycoses, viral and bacterial skin lesions;
• skin manifestations of syphilis;
• skin tumors;
• tuberculosis;
• acne (in particular, with rosacea and acne vulgaris);
• pregnancy.

Eye drops are not prescribed to patients with fungal and viral infections eyes, impaired integrity of the corneal epithelium, with trachoma, acute purulent and viral conjunctivitis, purulent infection of the eyelids and mucous membrane, purulent corneal ulcer, eye tuberculosis, as well as with conditions that developed after removal of a foreign object from the cornea.

Side effects of Prednisolone

The incidence and severity of side effects of Prednisolone are influenced by the dose used, duration, method, as well as the ability to comply with the circadian rhythm of drug use.

Systemic use of the drug may cause:

• fluid and Na+ retention in the body, development of nitrogen deficiency, hypokalemic alkalosis, hypokalemia, glucosuria, hyperglycemia, weight gain;
• secondary hypocortisolism and hypopituitarism (especially if taking corticosteroids coincides with periods of stress - injuries, surgeries, illnesses, etc.), growth suppression in children, Cushing's syndrome, menstrual irregularities, manifestation of LADA diabetes mellitus, decreased glucose tolerance , increasing the need for oral hypoglycemic agents and insulin in diabetics;
• increased blood pressure, CHF (or increased severity), hypercoagulation, ECG changes characteristic of hypokalemia, thrombosis, spread of necrotic lesions and slowed scar formation with possible rupture of the heart muscle in patients with acute/subacute MI, obliterating endarteritis;
• steroid myopathy, muscle weakness, aseptic necrosis of the head of the humerus and femur, loss of muscle mass, compression fracture spine and pathological fractures tubular bones, osteoporosis;
• ulcerative esophagitis, flatulence, digestive disorders, vomiting, nausea, increased appetite, development of steroid ulcers with possible complications in the form of perforation and bleeding from a peptic ulcer, pancreatitis;
• hypo- or hyperpigmentation of the skin, skin atrophy and/or subcutaneous tissue, the appearance of acne, atrophic stripes, abscesses, delayed wound healing, ecchymosis, petechiae, thinning of the skin, increased sweating, erythema;
• mental disorders (possible hallucinations, delirium, euphoria, depression), pseudotumor cerebri syndrome (most often develops in children when the dose is reduced too quickly and manifests itself in the form of decreased visual acuity, headaches, diplopia), sleep disorders, vertigo, dizziness, headache , development of cataracts with localization of opacification in the posterior part of the lens, ocular hypertension (in this case there is a possibility of damage to the optic nerve), steroid exophthalmos, glaucoma, sudden blindness (with the introduction of a d/i solution into the area of ​​the nasal sinuses, head and neck);
• hypersensitivity reactions (both local and generalized);
• general weakness;
• fainting states.

Effects of application on the skin:

• telangiectasia;
• purpura;
• steroid acne;
• burning, irritation, dryness and itching of the skin.

When applied to large surfaces of the skin and/or with prolonged use of the ointment, systemic effects, hypertrichosis develop, atrophic changes and secondary infection of the skin are also possible.

Treatment with eye drops may be accompanied by ocular hypertension, damage to the optic nerve, impaired visual acuity/narrowing of the visual field, an increased likelihood of perforation of the cornea, and the development of cataracts with clouding localized in the posterior part of the lens. IN in rare cases the spread of a fungal or viral eye disease is possible.

Signs of withdrawal syndrome

One of the consequences of the use of GCS may be “withdrawal syndrome”. Its severity depends on the functional state of the adrenal cortex. In mild cases, after stopping treatment with Prednisolone, malaise, weakness, fatigue, muscle pain, loss of appetite, hyperthermia, and exacerbation of the underlying disease are possible.

In severe cases, the patient may develop a hypoadrenal crisis, which is accompanied by vomiting, convulsions, and collapse. Without the introduction of GCS into short terms death occurs from acute cardiovascular failure.

Instructions for use of Prednisolone

Instructions for the use of Prednisolone in injections

The solution is administered intravenously, intramuscularly and intraarticularly.

The method of administration and dosage of Prednisolone (Prednisolone Nycomed, Prednisolone hemisuccinate) are selected individually by the attending physician, taking into account the type of pathology, the severity of the patient’s condition, and the location of the affected organ.

In severe and life-threatening conditions, the patient is prescribed pulse therapy using ultra-high doses for a short period of time. For 3-5 days, he is given 1-2 g of prednisolone daily by intravenous drip infusion. The duration of the procedure is from 30 minutes to 1 hour.

During treatment, the dosage is adjusted depending on the patient's response to therapy.

It is considered optimal to administer Prednisolone intravenously. For intra-articular administration, ampoules with Prednisolone are used only in cases where the tissue inside the joint is affected by the pathological process.

Positive dynamics are a reason to transfer the patient to tablets or suppositories with prednisolone. Treatment with tablets is continued until stable remission develops.

If it is not possible to administer Prednisolone intravenously, the medicine should be injected deep into the muscle. However, it should be borne in mind that with this method it is absorbed more slowly.

IN human body The release of adrenal hormones into the bloodstream occurs between 6 and 8:00 am, so injections should also be given at this time. The entire daily dose is usually administered at once. If this is not possible, at least ⅔ of the prescribed dose is administered in the morning, the remaining third should be administered at lunchtime (at approximately 12:00).

Depending on the pathology, the dose can range from 30-1200 mg/day. (with its subsequent decrease).

Children aged from two months to 1 year are administered from 2 to 3 mg/kg. Dosage for children from one to 14 years of age is 1-2 mg/kg (as a slow, 3-minute intramuscular injection). If necessary, after 20-30 minutes the medicine is re-administered in the same dose.

In case of defeat large joint 25 to 50 mg of prednisolone is injected into it. From 10 to 25 mg is injected into medium-sized joints, and from 5 to 10 mg into small joints.

Prednisolone tablets: instructions for use

The patient is transferred to taking tablets, following the principle of gradual withdrawal of GCS.

If HRT is used, the patient is prescribed 20 to 30 mg of prednisolone per day. Maintenance dose - from 5 to 10 mg/day. For some pathologies - for example, with nephrotic syndrome - it is advisable to prescribe more high doses.

For children, the starting dose is 1-2 mg/kg/day. (it should be divided into 4-6 doses), maintenance - from 0.3 to 0.6 mg/kg/day. When prescribing, the daily secretory rhythm of endogenous steroid hormones is taken into account.

Prednisolone ointment: instructions for use

The ointment is a means of external therapy. It should be applied to the affected areas of the skin in a thin layer from 1 to 3 times a day. An occlusive dressing can be applied to limited pathological lesions to enhance the effect.

When used in children over one year of age, the drug should be used for the shortest possible course. You should also exclude measures that enhance the absorption and resorption of prednisolone (occlusive, fixing, warming dressings).

Eye drops: instructions for use

Instillations of the drug are carried out 3 times a day, instilling 1-2 drops of solution into the conjunctival cavity of the affected eye. In the acute phase of the disease, the instillation procedure can be repeated every 2-4 hours.

For patients who have undergone ophthalmic surgery, drops are prescribed 3-5 days after surgery.

How long can you take Prednisolone?

Glucocorticosteroid therapy is aimed at achieving maximum effect with the lowest possible doses.

The duration of treatment depends on the patient's diagnosis and individual response to treatment. In some cases, the course lasts up to 6 days; with HRT it lasts for months. The duration of external therapy using Prednisolone ointment is usually from 6 to 14 days.

Dosage for animals

The dosage for dogs and cats is selected individually depending on the indications.

So, for example, with infectious peritonitis, a cat should be given orally 1 r./day. 2-4 mg/kg of prednisolone, for chronic panleukopenia - 2 times/day. 2.5 mg each.

The standard dosage for a dog is 1 mg/kg 2 times a day. Treatment lasts 14 days. Upon completion of the course, you must take tests and be examined by a doctor. When discontinuing the drug, the dose for dogs should be reduced by 25% every 14 days.

Overdose

Overdose is possible with long-term use of the drug, especially if the patient is prescribed high doses. It manifests itself as peripheral edema, increased blood pressure, and increased side effects.

In case of acute overdose, you should immediately rinse the stomach or give the patient an emetic. Prednisolone does not have a specific antidote. If chronic overdose symptoms appear, it is necessary to reduce the dose used.

Interaction

Interaction with other drugs is observed only with systemic use of Prednisolone.

Rifampicin, antiepileptic drugs, barbiturates accelerate the metabolism of prednisolone and weaken its effect. The effectiveness of the drug is also reduced in combination with antihistamines.

Carbonic anhydrase inhibitors, amphotericin B, thiazide diuretics increase the likelihood of severe hypokalemia, sodium-containing drugs increase blood pressure and edema.

In combination with Paracetamol, the risk of developing hepatotoxic effects increases, in combination with tricyclic antidepressants, it is possible to increase the mental disorders associated with taking prednisolone (including the severity of depression), in combination with immunosuppressants - an increased risk of developing infection and lymphoproliferative processes.

In combination with ASA, NSAIDs and alcohol, the likelihood of developing peptic ulcers and bleeding from ulcerative defects increases.

Oral contraceptives change the pharmacodynamic parameters of prednisolone, thereby enhancing its therapeutic and toxic effect.

Prednisolone weakens the anticoagulant effect of anticoagulants, as well as the effect of insulin and oral hypoglycemic agents.

The use of prednisolone in immunosuppressive doses in combination with live vaccines can provoke viral replication, decreased antibody production, and development of viral diseases. In case of use with inactivated vaccines the risk of decreased antibody production increases and neurological disorders.

With long-term use, it increases the content of folic acid; in combination with diuretics, it can provoke disturbances in electrolyte metabolism.

Terms of sale

To purchase Prednisolone, you must have a prescription for the drug.

Prednisolone recipe in Latin (for intramuscular administration to a child up to one year):

Rp: Sol. Prednisoloni hydrochloride 3% - 1.0

D.t.d. N 3 in amp.

S. IM 0.7 ml (IM – 2 mg/kg/day; IV – 5 mg/kg/day)

Storage conditions

The ointment retains its properties at a temperature of 5-15°C, tablets and solution for systemic use - at temperatures up to 25°C, eye drops - at a temperature of 15-25°C.

The contents of an opened bottle of drops must be used within 28 days.

Best before date

For ointments, tablets and solution for systemic use - two years, for eye drops - three years.

Special instructions

Treatment with Prednisolone should be stopped slowly, gradually reducing the dose.

For patients with a history of psychosis, high doses are allowed to be prescribed only under the strict supervision of a physician.

How to “get off” Prednisone?

Treatment with Prednisolone should be discontinued gradually. Dose reduction is carried out by weekly reducing the dose used by ⅛ or taking the last dose every other day and reducing it by ⅕ (this method is faster).

At fast way on a day without Prednisolone, the patient is advised to stimulate the adrenal glands using UHF or DQV on their projection, take ascorbic acid (500 mg/day), administer insulin in increasing doses (starting - 4 units, then increase it by 2 units for each dose; the highest dose is 16 units).

Insulin should be injected before breakfast, and the person should remain under observation for 6 hours after the injection.

If Prednisolone is prescribed for bronchial asthma, it is recommended to switch to inhaled steroids. If the indication for use is autoimmune disease- for mild cytostatics.

Features of the diet when taking Prednisolone

In addition, it is necessary to limit the amount of high-calorie foods with high content carbohydrates and fats (their consumption during GCS therapy increases blood glucose levels and speed dial weight), table salt and liquid.

When preparing food, you need to use products that contain potassium salts, calcium and protein (dietary meats, dairy products, fruits, hard cheeses, baked potatoes, prunes, apricots, nuts, zucchini, etc.).

What can replace Prednisolone?

Analogues in composition for dosage forms for systemic use: Prednisolone Nycomed (in ampoules), Prednisolone Nycomed in tablets, Prednisolone Bufus (solution), Medopred (solution), Prednisol (solution).

Similar drugs with a similar mechanism of action: Betamethasone, Hydrocortisone, Dexazone, Dexamed, Dexamethasone, Kenalog, Lemod, Medrol, Deltasone, Metipred, Rektodelt, Triamcinolone, Flosterone.

Ointment analogues: Prednisolone-Ferein, Hydrocortisone.

Analogs of eye drops: Hydrocortisone, Dexamethasone, Dexapos, Maxidex, Oftan Dexamethasone, Dexoftan, Prenacid, Dexamethasonelong, Ozurdex.

Alcohol compatibility

Alcohol and corticosteroids are incompatible.

Prednisolone during pregnancy

Pregnancy and lactation are contraindications to the use of GCS. The use of these drugs is allowed only for health reasons.

Newborns whose mothers received Prednisolone during pregnancy should be under medical supervision due to the likelihood of developing hypocortisolism.

In experiments on animals, the teratogenicity of the drug was established.

Reviews of Prednisolone

Reviews about Prednisolone in tablets and injections are quite contradictory: on the one hand, the medicine is very effective, on the other, it has wide range side effects and long-term use causes withdrawal syndrome. Also, some people using the drug note that the injection is painful.

However, it is injections for children and adults that often make it possible to very quickly stop the pathological process and even save lives.

To reduce the risk of side effects and their severity, if long-term use of Prednisolone is necessary, it is very important to follow the following rules:

• the drug is prescribed in situations where the therapeutic effect is not achieved when using less active agents (with the exception of life-threatening pathologies, adrenogenital syndrome, hypocortisolism);
• treatment begins with the minimum effective dose, which is increased if necessary until the desired result is obtained;
• the dosage is selected individually depending more on the patient’s response to therapy and the characteristics of the disease than on body weight and age;
• after obtaining the desired result, the dose is gradually reduced to the lowest at which the achieved effect is maintained;
• The drug should be taken taking into account the circadian rhythm;
• After the patient’s condition has stabilized, it is advisable to transfer him to alternative therapy.

As for dosage forms for topical use, they are mostly positive. At the same time, patients using eye drops and ointment, practically do not notice adverse reactions.

Prednisolone price

The price of Prednisolone tablets 5 mg No. 40 in Ukraine is from 37 UAH, in Russia they can be bought on average for 190 rubles. The price of Prednisolone in ampoules of 30 mg No. 3 is from 28 UAH; in Russian pharmacies, injections (package No. 3) will cost an average of 20-60 rubles. The price of Prednisolone ointment is from 19.5 UAH and from 13 rubles, respectively.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

Pharmacy 36.6

• Prednisolone-Richter table. 5mg N100GEDEON RICHTER
• Prednisolone ointment 0.5% 15gBIOSYNTHESIS

ZdravZone

• Prednisolone-Nycomed 25mg/ml solution for injection 1ml No. 25 ampoulesNycomed Austria GmbH
• Prednisolone-Nycomed 25mg/ml injection solution 1ml No. 50 ampoulesNycomed Austria GmbH
• Prednisolone 5 mg No. 100 tablets Akrikhin KhFK OJSC
• Prednisolone ointment 0.5% 10gNizhpharm OJSC
• Prednisolone ointment 0.5% 15g Biosynthesis OJSC

Pharmacy IFC

• PrednisoloneUpdate ZAO PFK, Russia
• PrednisoloneSintez AKO OJSC (Kurgan), Russia

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Pharmacy24

• PrednisoloneNizhpharm (Russia, Nizhny Novgorod)
• PrednisoloneRed Star (Ukraine, Kharkov)
• Prednisolone Darnitsa (Ukraine, Kyiv)
• Prednisolone solution for injection. 30mg/ml 1ml amp. No.5Biopharma (Ukraine, Kyiv)
• Prednisolone solution for injection 30 mg/ml 1 ml ampoule No. 3Biopharma (Ukraine, Kyiv)

PaniPharmacy

• Prednisolone ointment 0.5% 10g
• Prednisolone ointment 0.5% 10g
• Prednisolone tablet 5mg No. 40

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BIOSPHERE

• Prednisolone 30 mg/ml No. 3 solution d/in.amp.Agio Pharmaceuticals (India)
• Prednisolone 0.5% 10 g ointment in tube
• Prednisolone 5 mg No. 60 tablet Biosynthesis (Russia)
• Prednisolone 5 mg No. 100 tablet Simpex Pharma (India)
• Prednisolone Nycomed 25 mg/ml No. 3 solution d/in.

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PLEASE NOTE! Information about medications on the site is for reference and general information, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medications in the course of treatment. Before use medicinal product Prednisolone, be sure to consult with your doctor.

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Prednisolone, injections

Other corticosteroid drugs>>

Price

Average price online* 37 rub. (pack of 3 ampoules)

Where to buy:

Instructions for use

Prednisolone (Prednisolonum) is a synthetic drug belonging to the group of glucocorticosteroids.

Available in several dosage forms: ointment, tablets and injections.

Antiallergic, anti-inflammatory, immunosuppressive agent, superior in activity to cortisone and hydrocortisone by 3-4 times. Analogues are: decortin, medopred, inflanefran, prednisol, prelnihexal.

Prednisolone for injection is a colorless (or yellowish) water-soluble substance.

Available in ampoules sealed in cardboard packages of 3,5,6,10 and 20 pieces (30 mg prednisolone sodium phosphate/1 ml injection solution).

Application

The drug for intravenous or intramuscular administration refers primarily to emergency aid used in the following cases:

• in case of severe allergic reactions (Quincke's edema, anaphylactic shock, attack bronchial asthma);
• in case of acute renal and hepatic failure that developed in the postoperative or postpartum period;
• with severe rheumatic fever;
• state of shock (cardiogenic, burn, traumatic shock);
• with cerebral edema;
• with acute hepatitis;
• in acute adrenal insufficiency
• in case of poisoning with aggressive liquids that cause burns to the mucous membrane.

A complete list of indications for prednisolone is here.

In addition to emergency care, the medicine is used in complex therapy in the treatment of malignant tumor processes, autoimmune, chronic pulmonary and dermatological diseases.

Indications for the use of prednisolone are also some cardiac pathologies, in particular, exudative pericarditis and rheumatoid myocarditis, as well as a decrease in threshold excitation in patients with an implanted cardiac stimulator.

The drug is used in hematology - in the treatment of leukemia, anemia, MDS, pathologies associated with bone marrow dysfunction.

Important! You should not refuse to take prednisolone when prescribed by a specialist. This is a very effective and time-tested drug.

Many patients who are far from medicine believe that “hormonal” drugs cause irreparable harm to the body, and therefore either stop taking the medicine prematurely or do not take the medicine at all.

This approach can, in some cases, lead to dire consequences, many of which are irreversible.

With a correctly calculated dosage prescribed by a specialist, taking into account indications and health status, the drug will not cause serious complications. Remember that absolutely all medications (including those of natural origin) have side effects that are much more serious than those caused by corticosteroids. Therefore, you should take prednisolone (medopred) exactly according to the regimen drawn up by your attending physician.

Dosage

Dosage and duration treatment course assigned individually.

In most cases, the dosage is indicated for intramuscular administration. Only “jet” means from a syringe directly into a vein.

Prednisolone is administered intravenously or intramuscularly. When administered intravenously, the medicine is first administered as a stream, then switched to drip mode.

The treatment regimen indicated below is generalized, since it does not take into account the patient’s health status and the presence of relative contraindications:

for acute adrenal insufficiency - from 100 mg to 200 mg once, for 3-14 days;

in the treatment of bronchial asthma - from 75 mg to 675 mg per course of treatment (from 3 to 16 days);

in shock conditions accompanied by a drop in blood pressure, 50-150 mg is injected in a stream; in severe cases, the dose is increased to 400 mg (the maximum daily dose is 1000 mg);

Treatment should be carried out by a medical professional; self-medication is dangerous. Do not exceed the indicated dosages!

for complications after operations and acute poisoning, the medicine is administered at 25-75 mg per day (in severe cases, increase to 300-1500 mg per day).

for rheumatoid arthritis, 75-125 mg per day is indicated for a course of treatment lasting 10 days;

in severe forms of hepatitis, 75-100 mg per day is prescribed for a course of treatment designed for 7-10 days;

for internal burns of the respiratory and digestive organs, from 75 to 400 mg per day for 5-18 days.

If the medicine cannot be administered intravenously, intramuscular injections are prescribed. After stabilization of the condition, prednisolone is prescribed in capsules (tablets) with a gradual reduction in dose.

There is also intra-articular administration, but it is carried out only by a doctor, dosages are selected only individually for each patient.

Contraindications

In emergency (shock) conditions, prednisolone is administered without taking into account contraindications, as an emergency treatment.

The drug is not used in therapeutic courses for severe arterial hypertension, gastric and duodenal ulcers, reflux disease, osteoporosis, Cushing's disease.

Contraindications include infections such as chickenpox, herpes, herpes zoster, and active form tuberculosis, pregnancy (first trimester, especially), lactation period.

Side effects

Weight gain, potassium deficiency (hypokalemia), growth retardation in children, Cushing's syndrome (moon face), increased blood pressure, thrombosis, muscle atrophy, thinning of the skin, digestive disorders, nausea.

From the nervous system, manifestations such as depression, hallucinations, decreased visual acuity, general weakness, headache.

The above symptoms are possible, but they do not appear in every case. In general, the drug is well tolerated by patients, even with long-term use.

Special instructions

The drug is not recommended to be taken simultaneously with salicylates, barbiturates, diuretics, cardiac glycosides. When taking the medicine, it is necessary to monitor blood pressure, donate blood for sugar levels, examine stool for occult blood, and take an x-ray (for arthritis and bursitis).

Pharmakinetics

At intravenous administration Prednisolone's effect occurs instantly, a little slower with intramuscular injections. The drug binds to plasma proteins (globulins and albumins), is metabolized in the liver (mainly) and in the kidneys. Duration of exposure is 24-36 hours.

Terms of sale

The drug is available with a prescription.

Prednisolone is hormonal medicine, which is usually used for acute diseases and life-threatening conditions. When is it prescribed to children and in what form is it used? How does this medication work? children's body, and what side effects may occur in a child when treated with Prednisolone?

Release form

Prednisolone is manufactured by several companies, and sometimes there is a word next to the name of the medication indicating the manufacturer (for example, Prednisolone Nycomed). The drug is presented in the following types.

• Pills. They are usually flat-cylindrical and white, and one pack contains from 10 to 120 tablets (most often polymer bottles of 100 pieces are produced).
• Ointment, which is used for external processing. This is a thick white mass placed in aluminum tubes in quantities of 10 g or 15 g.
• Ampoules with solution, which can be injected into a muscle or injected into a vein. Such ampoules contain 1 or 2 ml of a clear solution. The liquid is colorless, yellowish or yellow-greenish. One package includes 3, 5 or more ampoules.

Prednisolone is not available in suppositories, drops, capsules, syrup or other forms.

Compound

All dosage forms The drug contains prednisolone as the main ingredient. It is presented in the following dosages:

• in 1 tablet – 1 mg or 5 mg;
• in 1 ml of solution for injection - 15 mg or 30 mg in the form of sodium phosphate;
• in 1 gram of ointment – ​​5 mg.

Excipients in different forms and medicines for different manufacturers differ, so the exact composition should be found in the instructions or on the packaging of a particular medication.

Operating principle

Prednisolone is a synthetic hormone from the group of glucocorticosteroids and acts similarly to hormonal compounds that are produced in the adrenal glands.

This substance:

• relieves shock and prevents death in a state of shock;
• quickly and effectively eliminates the inflammatory process, regardless of its severity and location;
• suppresses exudation - active release of fluid from inflamed tissues;
• stops the development of an allergic reaction and eliminates allergy symptoms such as rash, swelling, itching and others;
• stops the active proliferation of cells at the site of damage, thereby preventing the appearance of scars;
• suppresses the immune system.

All these effects of Prednisolone develop very quickly, and the effect of the drug itself is very strong, so it is used in life-threatening situations or in cases where other medications have been ineffective. If there is a possibility of replacing such a medicine with other drugs, it should be used.

Prednisolone also has the following properties:

• stimulation of protein breakdown in tissues and bloodstream, as well as the synthesis of protein molecules in liver cells;
• increased blood glucose levels;
• retention of Na+ and water, which causes swelling;
• increased excitability nerve cells in the brain;
• reducing potassium absorption in the gastrointestinal tract and stimulating its excretion from the body;
• redistribution of fat reserves with an increase in its amount in the upper body;
• lowering the threshold for convulsive readiness;
• inhibition of the production of glucocorticoids, as well as FSH and TSH.

Such effects of the drug are not therapeutic, but must be taken into account, since they are the ones that cause side effects.

Indications

Bronchial asthma

Joint inflammation

• acute dysfunction of the adrenal glands;
• allergic conjunctivitis;
• uveitis and other inflammatory eye diseases;
• agranulocytosis, acute leukemia, thrombocytopenic purpura, hemolytic anemia and other pathologies of the hematopoietic system;
• organ transplantation;
• acute hepatitis or hepatic coma;
• thyrotoxic crisis or thyroiditis;
• multiple myeloma;
• sarcoidosis, tuberculosis, aspiration pneumonia and others serious illnesses lungs;
• poisoning with alkalis and other cauterizing liquids.

Poisoning

Prednisolone ointment is prescribed for eczema, atopic dermatitis, contact dermatitis, toxicerma, psoriasis and other skin diseases. In addition, this form is prescribed for tendovaginitis, bursitis and keloid scars.

At what age is it prescribed?

There are no age restrictions for treating children with Prednisolone, but due to the fact that such a medication can negatively affect growth processes in childhood, this hormone is prescribed only if there are serious indications and only under medical supervision.

In addition, it is important not to forget that such a remedy is used only for acute conditions and they always try to prescribe it in the minimum dose and for the shortest possible period.

Contraindications

If Prednisolone is prescribed to a child for health reasons, then there is only one contraindication for its use - intolerance to such a medicine. However, many diseases require increased attention doctor when prescribing Prednisolone. Such diseases include various pathologies Gastrointestinal tract, infections (chickenpox, measles, herpes, tuberculosis, etc.), endocrine diseases, severe liver pathologies, glaucoma and so on.

If the child has any serious illness, the issue of using Prednisolone is decided individually.

Side effects

During treatment with Prednisolone injections or tablets, various negative effects may be observed, For example:

• vomiting or nausea;
• decreased adrenal activity;
• decreased glucose tolerance;
• development of Itsenko-Cushing syndrome;
• change in appetite;
• development of diabetes mellitus (called steroid diabetes);
• the appearance of erosive esophagitis, bleeding from the wall of the stomach or intestines, as well as steroid ulcers of the gastrointestinal tract;
• growth slowdown;
• delayed sexual development;
• irregular heartbeat, increased blood pressure, bradycardia;
• bloating;
• mental disorders such as depression or paranoia;
• increase in intracranial or intraocular pressure;
• headaches or insomnia;
• increased sweating;

Insomnia

Stunting

Side effects

• weight gain;
• eye infection (secondary);
• the appearance of peripheral edema;
• weakness, fatigue, muscle pain and other symptoms of hypokalemia;
• the appearance of stretch marks or acne;
• allergic reactions in the form of skin rash, itching or other symptoms;
• exacerbation of infectious diseases;
• withdrawal syndrome.

The use of ointment can provoke the appearance of “stars”, skin itching, excessive dryness, acne, burning and other skin problems.

If a large area of ​​skin is treated with this Prednisolone, the effects of treatment will be similar to the side effects from injections or taking pills.

Fatigue

Weight gain

Instructions for use

The form of the medication, the required dosage and duration of use of Prednisolone are determined by the doctor, taking into account many factors, including the diagnosis, the patient’s condition, the age of the child, and his weight in kilograms. Prednisolone for injection can be administered intravenously either as a bolus or through a dropper (the medicine must be diluted with saline). Exactly intravenous injections used in acute conditions when immediate assistance is required.

If injections into a vein are not possible, the medicine is administered intramuscularly, and if the condition improves, the injections are replaced with tablets. If the drug is prescribed for long period, it should be discontinued gradually, reducing the daily dose. The longer the treatment was carried out, the slower the medicine was discontinued.

Prednisolone tablets are most often given once at 6-8 am, since it is at this time that glucocorticoids are released in the human body. If the dosage is very large, it can be divided into several doses. In this case, the medication is given in a larger dose in the morning, and the remaining amount is taken at 12 o’clock. Taking Prednisolone tablets is recommended during meals or immediately after meals. The medicine is taken with a small volume of liquid.

Dosage form:  solution for intravenous and intramuscular administration Compound:

1 ml of the drug contains:

active substance: prednisolone sodium phosphate (in terms of prednisolone) 30 mg;

excipients: sodium hydrogen phosphate (sodium hydrogen phosphate anhydrous) 0.5 mg, sodium dihydrogen phosphate dihydrate 0.35 mg, propylene glycol 150 mg, water for injection up to 1 ml.

Description:

Clear or slightly opalescent, colorless or slightly colored liquid.

Pharmacotherapeutic group:glucocorticosteroid ATX:  

H.02.A.B.06 Prednisolone

Pharmacodynamics:

Prednisolone is a synthetic glucocorticosteroid drug, a dehydrated analogue of hydrocortisone. It has anti-inflammatory, antiallergic, desensitizing, antishock, antitoxic and immunosuppressive effects.

Suppresses the release of beta-lipotropin by the pituitary gland, but does not reduce the concentration of circulating beta-endorphin. Inhibits secretion thyroid-stimulating hormone(TSH) and follicle-stimulating hormone (FSH). Increases the excitability of the central nervous system (CNS), reduces the number of lymphocytes and eosinophils, increases red blood cells (stimulates the production of erythropoietins).

Interacts with cytoplasmic glucocorticosteroid receptors (GSK) and forms a complex that penetrates the cell nucleus and stimulates mRNA synthesis; the latter induces the formation of proteins, including lipocortin, that mediate cellular effects. Lipocortin inhibits phospholipase A2, suppresses the release of arachidonic acid and suppresses the synthesis of endoperoxides, prostaglandins (Pg), leukotrienes, which contribute to inflammation, allergies, and more.

Protein metabolism : reduces the amount of globulins in plasma, increases the synthesis of albumins in the liver and kidneys (with an increase in the albumin/globulin ratio in the blood plasma), reduces synthesis and enhances protein catabolism in muscle tissue.

Lipid metabolism: increases the synthesis of higher fatty acids and triglycerides, redistributes fat (fat accumulation occurs mainly in the area shoulder girdle, face, abdomen), leads to the development of hypercholesterolemia.

Carbohydrate metabolism: increases the absorption of carbohydrates from gastrointestinal tract; increases the activity of glucose-6-phosphatase (increasing the flow of glucose from the liver into the blood); increases the activity of phosphoenolpyruvate carboxylase and the synthesis of aminotransferases (activation of gluconeogenesis); promotes the development of hyperglycemia.

Water-electrolyte metabolism: retains sodium ions and water in the body, stimulates the excretion of potassium ions (mineralocorticoid activity), reduces the absorption of calcium ions from the gastrointestinal tract, reduces bone mineralization.

Anti-inflammatory effect associated with inhibition of the release of inflammatory mediators by eosinophils and mast cells; inducing the formation of lipocortins and reducing the number of mast cells that produce hyaluronic acid; with a decrease in capillary permeability; stabilization cell membranes(especially lysosomal) and organelle membranes.

Immunosuppressive effect caused by involution of lymphoid tissue, inhibition of the proliferation of lymphocytes (especially T-lymphocytes), suppression of the migration of B-lymphocytes and the interaction of T- and B-lymphocytes, inhibition of the release of cytokines (interleukin-1, 2; interferon gamma) from lymphocytes and macrophages and a decrease antibody formation.

Antiallergic effect develops as a result of a decrease in the synthesis and secretion of allergy mediators, inhibition of the release of histamine and other biologically active substances from sensitized mast cells and basophils, a decrease in the number of circulating basophils, T- and B-lymphocytes, mast cells; suppressing the development of lymphoid and connective tissue, reducing the sensitivity of effector cells to allergy mediators, inhibiting antibody formation, changing the body's immune response.

For obstructive diseases respiratory tract the effect is due mainly to inhibition of inflammatory processes, prevention or reduction of the severity of edema of the mucous membranes, reduction of eosinophilic infiltration of the submucosal layer of the bronchial epithelium and deposition of circulating immune complexes in the bronchial mucosa, as well as inhibition of erosion and desquamation of the mucous membrane. Increases the sensitivity of beta-adrenergic receptors of small and medium-sized bronchi to endogenous catecholamines and exogenous sympathomimetics, reduces the viscosity of mucus by reducing its production.

Suppresses the synthesis and secretion of adrenocorticotropic hormone and, secondarily, the synthesis of endogenous glucocorticosteroids.

Antishock and antitoxic effect is associated with an increase in blood pressure (due to an increase in the concentration of circulating catecholamines and restoration of the sensitivity of adrenoreceptors to them, as well as vasoconstriction), a decrease in the permeability of the vascular wall, membrane protective properties, and activation of liver enzymes involved in the metabolism of endo- and xenobiotics.

Inhibits connective tissue reactions during the inflammatory process and reduces the possibility of scar tissue formation.

Pharmacokinetics:

Up to 90% of prednisolone is bound to plasma proteins: transcortin (corticosteroid binding globulin) and albumin.

Prednisolone is metabolized in the liver, partially in the kidneys and other tissues, mainly through conjugation with glucuronic and sulfuric acids. Metabolites are inactive. It is excreted through the intestines and kidneys by glomerular filtration and is 80-90% reabsorbed by the tubules, 20% of the dose is excreted unchanged by the kidneys. The plasma half-life after intravenous administration is 2-3 hours.

Indications:

Prednisolone is prescribed for emergency therapy in conditions requiring a rapid increase in the concentration of glucocorticosteroids in the body:

Shock (burn, traumatic, surgical, toxic, cardiogenic) - when vasoconstrictors, plasma replacement drugs and other symptomatic therapy are ineffective;

Allergic reactions (acute severe forms), blood transfusion shock, anaphylactic shock, anaphylactoid reactions;

Brain swelling (including due to a brain tumor or associated with surgery, radiation therapy or head trauma);

Bronchial asthma (severe form), astatic status;

Systemic connective tissue diseases (systemic lupus erythematosus, rheumatoid arthritis);

Acute adrenal insufficiency;

Thyrotoxic crisis;

Acute hepatitis, hepatic coma;

Decrease inflammatory phenomena and prevention of cicatricial contractions (in case of poisoning with cauterizing liquids).

Contraindications:

For short-term use for health reasons, the only contraindication is hypersensitivity to prednisolone or the components of the drug.

In children during the growth period, glucocorticosteroids should be used only when absolute indications and under the careful supervision of the attending physician.

With caution:

The drug should be prescribed for the following diseases and conditions:

Diseases of the gastrointestinal tract - peptic ulcer of the stomach and duodenum, esophagitis, gastritis, acute or latent peptic ulcer, recently created intestinal anastomosis, ulcerative colitis with the threat of perforation or abscess formation, diverticulitis;

Pre- and post-vaccination period (8 weeks before and 2 weeks after vaccination), lymphadenitis after BCG vaccination;

Immunodeficiency conditions (including acquired immunodeficiency syndrome (AIDS) or human immunodeficiency virus (HIV infection);

Diseases cardiovascular system(including recently transferred

myocardial infarction - in patients with acute and subacute myocardial infarction, the necrosis focus may spread, the formation of scar tissue may slow down and, as a result, the heart muscle will rupture), decompensated chronic heart failure, arterial hypertension,

hyperlipidemia);

Endocrine diseases - diabetes mellitus (including impaired carbohydrate tolerance), thyrotoxicosis, hypothyroidism, Itsenko-Cushing's disease, stage III-IY obesity);

Severe chronic renal and/or liver failure,

nephrourolithiasis;

Hypoalbuminemia and conditions predisposing to its occurrence;

Systemic osteoporosis, myasthenia gravis, acute psychosis, poliomyelitis (except for the form of bulbar encephalitis), open- and closed-angle glaucoma;

Pregnancy.

Pregnancy and lactation:

During pregnancy, the drug is used only in cases where the potential benefit to the mother outweighs the potential risk to the fetus.

Since glucocorticosteroids pass into breast milk, if necessary, use the drug during breastfeeding, it is recommended to stop breastfeeding.

Directions for use and dosage:

The intravenous drug is usually administered first as a bolus, repeated injections are carried out by drip.

The dose of the drug and the duration of treatment are determined by the doctor individually depending on the indications and severity of the disease.

In acute adrenal insufficiency a single dose of the drug is 100-200 mg, a daily dose is 300-400 mg.

For severe allergic reactions Prednisolone is administered in a daily dose of 100-200 mg for 3-16 days.

For bronchial asthma the drug is administered in a dose of 75 mg to 675 mg for a course of treatment from 3 to 16 days; in severe cases, the dose can be increased to 1400 mg per course of treatment or more with a gradual dose reduction.

For status asthmaticus administered at a dose of 500-1200 mg per day, followed by a decrease to 300 mg per day and transition to maintenance doses.

During thyrotoxic crisis 100 mg of the drug is administered in a daily dose of 200-300 mg; if necessary, the daily dose can be increased to 1000 mg. The duration of administration depends on the therapeutic effect, usually up to 6 days.

For shock resistant to standard therapy, at the beginning of therapy they are usually administered as a bolus, after which they switch to drip administration. If blood pressure does not increase within 10-20 minutes, repeat the injection of the drug. After being removed from state of shock continue drip administration until blood pressure stabilizes. A single dose is 50-150 mg (in severe cases - up to 400 mg). The drug is re-administered after 3-4 hours. The daily dose can be 300-1200 mg (with subsequent dose reduction).

In case of acute hepatic-renal failure (in acute poisoning, in the postoperative and postpartum periods, etc.) administer 25-75 mg per day; if indicated, the daily dose can be increased to 300-1500 mg per day or higher.

For rheumatoid arthritis and systemic lupus erythematosus administered in addition to systemic administration of the drug at a dose of 75-125 mg per day for no more than 7-10 days.

For acute hepatitis administer 75-100 mg per day for 7-10 days. In case of poisoning with cauterizing liquids with burns digestive tract and upper respiratory tract - prescribed at a dose of 75-400 mg per day for 3-18 days.

If intravenous administration is not possible administered intramuscularly in the same doses. After relief of the acute condition, it is prescribed orally in tablets, followed by a gradual reduction in the dose. With long-term use of the drug, the daily dose should be reduced gradually. Long-term therapy should not be stopped suddenly!

Children from 2 to 12 months - 2-3 mg/kg, from 1 to 14 years - 1-2 mg/kg intramuscularly; administered intravenously slowly (over 3 minutes). If necessary, this dose can be repeated after 20-30 minutes.

Side effects:

The incidence and severity of side effects depends on the duration of use, the size of the dose used and the ability to comply with the circadian rhythm of prednisolone administration.

From the endocrine system: decreased glucose tolerance, “steroid” diabetes mellitus or manifestation of latent diabetes mellitus, suppression of adrenal function, Itsenko-Cushing syndrome (moon-shaped face, pituitary-type obesity, hirsutism, increased blood pressure, dysmenorrhea, amenorrhea, muscle weakness, stretch marks), delay sexual development in children.

From the digestive system: nausea, vomiting, pancreatitis, “steroid” ulcer of the stomach and duodenum, erosive esophagitis, gastrointestinal bleeding and perforation of the wall of the gastrointestinal tract, increased or decreased appetite, indigestion, flatulence, hiccups. In rare cases, increased activity of liver transaminases and alkaline phosphatase.

From the cardiovascular system: arrhythmias, bradycardia (up to cardiac arrest); development (in predisposed patients) or increased severity of heart failure, changes in the electrocardiogram characteristic of hypokalemia, increased blood pressure, hypercoagulation, thrombosis. In patients with acute and subacute myocardial infarction - the spread of necrosis, slowing down the formation of scar tissue, which can lead to rupture of the heart muscle.

From the nervous system: delirium, disorientation, euphoria, hallucinations, manic-depressive psychosis, depression, paranoia, increased intracranial pressure, nervousness or anxiety, insomnia, dizziness, vertigo, pseudotumor of the cerebellum, headache, convulsions.

From the senses: posterior subcapsular cataract, increased intraocular pressure with possible damage to the optic nerve, a tendency to develop secondary bacterial, fungal or viral eye infections, trophic changes in the cornea, exophthalmos, sudden loss of vision.

Metabolism: increased calcium excretion, hypocalcemia, weight gain, negative nitrogen balance (increased protein breakdown), increased sweating.

Due to mineralocorticoid activity fluid and sodium retention (peripheral edema), hypernatremia, hypokalemic syndrome (hypokalemia, arrhythmia, myalgia or muscle spasm, unusual weakness and fatigue).

From the musculoskeletal system: slower growth and ossification processes in children (premature closure of epiphyseal growth zones), osteoporosis (very rarely - pathological bone fractures, aseptic necrosis of the head of the humerus and femur), rupture of muscle tendons, “steroid” myopathy, decreased muscle mass (atrophy).

From the skin and mucous membranes: delayed wound healing, petechiae, ecchymoses, skin thinning, hyper- or hypopigmentation, “steroid” acne, stretch marks, tendency to develop pyoderma and candidiasis.

Allergic reactions: skin rash, itching, anaphylactic shock, local allergic reactions.

Local reactions with parenteral administration : burning, numbness, pain, tingling at the injection site, infection at the injection site, rarely - necrosis of surrounding tissues, scarring at the injection site; atrophy of the skin and subcutaneous tissue with intramuscular injection(injection into the deltoid muscle is especially dangerous).

With intravenous administration: arrhythmias, “flushes” of blood to the face, convulsions.

Others: development or exacerbation of infections (the appearance of this side effect is facilitated by jointly used immunosuppressants and vaccination), leukocyturia, withdrawal syndrome.

Overdose:

There may be an increase in dose-dependent side effects. It is necessary to reduce the dose of prednisolone.

Treatment: symptomatic.

Interaction:

There may be pharmaceutical incompatibility of prednisolone with other intravenously administered drugs - it is recommended to administer it separately from other drugs (intravenous bolus, or through another dropper, as a second solution). When mixing a solution of prednisolone with heparin, a precipitate forms.

Prednisolone increases the toxicity of cardiac glycosides (due to the resulting hypokalemia, the risk of developing arrhythmias increases).

Accelerates the elimination of acetylsalicylic acid, reduces its concentration in the blood (when prednisolone is discontinued, the concentration of salicylates in the blood increases and the risk of side effects increases).

When used simultaneously with live antiviral vaccines and against the background of other types of immunizations, it increases the risk of viral activation and the development of infections.

Increases the metabolism of isoniazid, mexiletine (especially in “fast acetylators”), which leads to a decrease in their plasma concentrations.

Increases the risk of developing hepatotoxic reactions of paracetamol (induction of “liver” enzymes and the formation of a toxic metabolite of paracetamol).

Increases (with long-term therapy) folic acid content. Hypokalemia caused by glucocorticosteroids can increase the severity and duration of muscle blockade due to muscle relaxants.

In high doses, it reduces the effect of somatropin.

Prednisolone reduces the effect of hypoglycemic drugs; enhances the anticoagulant effect of coumarin derivatives.

Weakens the effect of vitamin D on the absorption of calcium ions in the intestinal lumen.

Ergocalciferol and parathyroid hormone prevent the development of osteopathy caused by glucocorticosteroids.

Reduces the concentration of praziquantel in the blood.

Cyclosporine (inhibits metabolism) and (reduces clearance) increases toxicity.

Thiazide diuretics, carbonic anhydrase inhibitors, other glucocorticosteroids and amphotericin B increase the risk of hypokalemia, sodium-containing drugs - edema and increased blood pressure.

Non-steroidal anti-inflammatory drugs (NSAIDs) and increase the risk of developing ulceration of the gastrointestinal tract (GIT) mucosa and bleeding, in combination with non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment of arthritis, it is possible to reduce the dose of glucocorticosteroids due to the summation of the therapeutic effect.

Indomethacin, displacing its connection with albumin, increases the risk of developing its side effects.

Amphotericin B and carbonic anhydrase inhibitors increase the risk of osteoporosis.

The therapeutic effect of glucocorticosteroids is reduced under the influence of phenytoin, barbiturates, ephedrine, theophylline, rifampicin and other inducers of microsomal liver enzymes (increased metabolic rate).

Mitotane and other inhibitors of adrenal function may necessitate an increase in the dose of glucocorticosteroids.

Clearance of glucocorticosteroids increases against the background of hormones thyroid gland.

Immunosuppressants increase the risk of developing infections and lymphoma or other lymphoproliferative disorders caused by the Epstein-Barr virus.

Estrogens (including oral estrogen-containing contraceptives) reduce the clearance of glucocorticosteroids, prolong the half-life and their therapeutic and toxic effects.

The appearance of hirsutism and acne is facilitated by the simultaneous use of other steroid hormonal drugs - androgens, estrogens, anabolic steroids, oral contraceptives.

Tricyclic antidepressants may increase the severity of depression caused by taking glucocorticosteroids (not indicated for the treatment of these side effects).

The risk of developing cataracts increases when used in conjunction with other glucocorticosteroids, antipsychotic drugs (neuroleptics), carbutamide and azathioprine.

Simultaneous administration with m-anticholinergic blockers (including antihistamines, tricyclic antidepressants with m-anticholinergic activity), nitrates contributes to the development of increased intraocular pressure.

Special instructions:

During treatment with prednisolone (especially long-term), observation by an ophthalmologist, monitoring of blood pressure, water and electrolyte balance, as well as peripheral blood patterns and blood glucose levels are necessary.

In order to reduce side effects, antacids can be prescribed, as well as increasing the intake of potassium ions into the body (diet, potassium supplements). Food should be rich in proteins, vitamins, and limit the content of fats, carbohydrates and table salt.

The effect of the drug is enhanced in patients with hypothyroidism and liver cirrhosis. The drug may worsen existing emotional instability or psychotic disorders. If a history of psychosis is indicated, high doses are prescribed under the strict supervision of a physician.

It should be used with caution in acute and subacute myocardial infarction - the necrosis focus may spread, the formation of scar tissue may slow down, and the heart muscle may rupture.

IN stressful situations During maintenance treatment (for example, surgery, trauma or infectious diseases), the dose of the drug should be adjusted due to the increased need for glucocorticosteroids.

With sudden withdrawal, especially in the case of previous use of high doses, the development of a “withdrawal” syndrome (anorexia, nausea, lethargy, generalized musculoskeletal pain, general weakness) is possible, as well as an exacerbation of the disease for which it was prescribed. During treatment with prednisolone, vaccination should not be carried out due to a decrease in its effectiveness (immune response). When prescribing for intercurrent infections, septic conditions and tuberculosis, it is necessary to simultaneously treat with bactericidal antibiotics.

In children during the growth period, glucocorticosteroids should be used only for absolute indications and under the careful supervision of the attending physician. Children who, during the treatment period, were in contact with patients with measles or chicken pox, specific immunoglobulins are prescribed prophylactically.

Due to the weak mineralocorticoid effect on replacement therapy for adrenal insufficiency, it is used in combination with mineralocorticoids.

In patients with diabetes mellitus, blood glucose levels should be monitored and therapy adjusted if necessary.

X-ray monitoring of the osteoarticular system (images of the spine, hand) is indicated.

Prednisolone in patients with latent infectious diseases of the kidneys and urinary tract can cause leukocyturia, which may have diagnostic value.

Prednisolone increases the content of 11- and 17-hydroxyketocorticosteroid metabolites.

Impact on the ability to drive vehicles. Wed and fur.:

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration attention and speed of psychomotor reactions.

Release form/dosage:

Solution for intravenous and intramuscular administration, 30 mg/ml.

Package:

1 ml of solution in neutral glass ampoules.

10 ampoules with instructions for use and a knife for opening ampoules or an ampoule scarifier are placed in a cardboard box.

5 or 10 ampoules are placed in a blister pack made of polyvinyl chloride film or polyethylene terephthalate tape and aluminum foil or paper with a polyethylene coating or without foil, or without paper.

1 or 2 blister packs with instructions for use and a knife for opening ampoules or an ampoule scarifier are placed in a cardboard pack.

When packaging ampoules with a break ring or break point, do not insert a knife for opening ampoules or an ampoule scarifier.

Storage conditions:

In a place protected from light at a temperature not exceeding 15°C.

Keep out of the reach of children.

Best before date: Do not use after the expiration date stated on the package. Conditions for dispensing from pharmacies: By prescription Registration number: Close Instructions Indications for use:
Collagenoses (a general name for diseases characterized by diffuse damage to connective tissue and blood vessels), rheumatism, infectious nonspecific polyarthritis (inflammation of several joints), bronchial asthma, acute lymphoblastic and myeloblastic leukemia (malignant blood tumor arising from hematopoietic cells of the bone marrow), infectious mononucleosis ( acute infectious disease, occurring with an increased rise in temperature, enlargement of the palatine lymph nodes, liver), neurodermatitis (skin disease caused by dysfunction of the central nervous disease), eczema (neuroallergic skin disease, characterized by weeping, itchy inflammation) and other skin diseases, various allergic diseases, Addison's disease (decreased adrenal function), acute adrenal insufficiency, hemolytic anemia(decreased hemoglobin content in the blood due to increased breakdown of red blood cells), glomerulonephritis (kidney disease), acute pancreatitis (inflammation of the pancreas); shock and collapse (sharp drop in blood pressure) during surgical interventions; to suppress the rejection reaction during homotransplantation (transplantation from one person to another) of organs and tissues.
Allergic, chronic and atypical conjunctivitis (inflammation of the outer membrane of the eye) and blepharitis (inflammation of the edges of the eyelids); inflammation of the cornea with intact mucosa; spicy and chronic inflammation anterior segment choroid, sclera (opaque part of the fibrous membrane eyeball) and episclera (the outer loose layer of the sclera in which blood vessels pass); sympathetic inflammation of the eyeball (inflammation of the anterior part of the choroid due to penetrating injury to the other eye); after injuries and operations with prolonged irritation of the eyeballs.

Pharmacological action:
Prednisolone is synthetic analogue The hormones cortisone and hydrocortisone secreted by the adrenal cortex. Prednisolone is 4-5 times more active than cortisone and 3-4 times more active than hydrocortisone when used orally. Unlike cortisone and hydrocortisone, prednisolone does not cause noticeable sodium and water retention and only slightly increases potassium excretion.
The drug has a pronounced anti-inflammatory, anti-allergic, anti-exudative, anti-shock, anti-toxic effect.
The anti-inflammatory effect of prednisolone is achieved mainly with the participation of cytosolic glucocorticosteroid receptors. The hormone-receptor complex, penetrating into the nucleus of the skin target cells (keratinocytes, fibroblasts, lymphocytes), enhances the expression of genes encoding the synthesis of lipocortins, which inhibit phospholipase A2 and reduce the synthesis of arachidonic acid metabolic products, cyclic endoperoxides, prostaglandins and thromboxane. The antiproliferative effect of prednisolone is associated with inhibition of the synthesis of nucleic acids (primarily DNA) in the cells of the basal layer of the epidermis and fibroblasts of the dermis. The antiallergic effect of the product is due to a decrease in the number of basophils, direct inhibition of the synthesis and secretion of biologically active substances.

Pharmacokinetics.
When taken orally, it is well absorbed from the gastrointestinal tract. The maximum concentration in blood plasma is reached after 90 minutes. after reception. In plasma, 90% of prednisolone is in bound form (with transcortin and albumin). Biotransformed by oxidation mainly in the liver; oxidized forms are glucuronidated or sulfated. It is excreted in urine and feces in the form of metabolites, partly unchanged. Penetrates the placental barrier and is found in small quantities in breast milk.

Prednisolone route of administration and dosage:
The dose is set individually. In acute conditions and as an introductory dose, 20-30 mg per day (4-6 tablets) is usually used. The maintenance dose is 5-10 mg per day (1-2 tablets). For some diseases (nephrosis, a kidney disease characterized by damage to the renal tubules with the development of edema and the appearance of protein in the urine), some rheumatic diseases, it is prescribed in higher doses. Treatment is stopped slowly, gradually reducing the dose. If there are indications of psychosis in the anamnesis (medical history), large doses are prescribed under the strict supervision of a physician. The dose for children is usually 1-2 mg per kg of body weight per day in 4-6 divided doses. When prescribing prednisolone, the daily secretory rhythm of glucocorticoids (the rhythm of the release of hormones from the adrenal cortex) must be taken into account: large doses are prescribed in the morning, medium doses in the afternoon, small doses in the evening.
For shock, 30-90 mg of prednisolone is administered intravenously slowly or by drip.
For other indications, prednisolone is prescribed at a dose of 30-45 mg intravenously slowly. If intravenous infusion is difficult, the product can be injected deep into the muscle. According to indications, prednisolone is administered repeatedly at a dose of 30-60 mg, intravenously or intramuscularly. After relief (removal) of the acute condition, prednisolone is prescribed orally in tablets, gradually reducing the dose.
In children, prednisolone is used at the following rate: at the age of 2-12 months - 2-3 mg/kg; 1-14 years - 1-2 mg/kg intravenously slowly (over 3 minutes). If necessary, the product can be reintroduced after 20-30 minutes.
The drug in the form of an injection suspension and solution for injection is intended for intra-articular, intramuscular and infiltration (impregnation of tissues) administration with strict adherence to asepsis (sterility). For intra-articular injection, it is recommended to administer 10 mg to small joints, 25 mg or 50 mg to large joints. The injection can be repeated more than once. After several injections, the severity of the therapeutic effect should be assessed. If the intensity is insufficient, decide on increasing the dose. After removing the needle from the joint, the patient must move the joint several times, bending and unbending it, for better distribution of the hormone. For infiltration administration into small affected parts of the body - 25 mg, into larger ones - 50 mg.
The eye suspension is instilled into the conjunctival sac (the cavity between the back surface of the eyelids and the front surface of the eyeball) 1-2 drops 3 times every day. The course of treatment is no more than 14 days.
It is recommended to regularly monitor blood pressure, conduct urine and stool tests, measure blood sugar levels, and administer anabolic hormonal products, antibiotics. You should especially carefully monitor the electrolyte (ionic) balance when using prednisolone in combination with diuretics. During long-term treatment with prednisolone, potassium products and an appropriate diet should be prescribed to prevent hypokalemia (low potassium levels in the blood). To reduce the risk of catabolism (tissue breakdown) and osteoporosis (malnutrition of bone tissue, accompanied by an increase in its fragility), methandrostenolone is used.

Prednisolone contraindications:
Severe forms hypertension(persistent rise in blood pressure), diabetes mellitus and Itsenko-Cushing's disease; pregnancy, stage III circulatory failure, acute endocarditis (inflammation internal cavities heart disease), psychosis, nephritis (inflammation of the kidneys), osteoporosis, peptic ulcer of the stomach and duodenum, recent operations, syphilis, active form of tuberculosis, old age.
Prednisolone is prescribed for diabetes mellitus with caution and only for absolute indications or for the treatment of insulin resistance (lack of response and insulin administration) associated with an increased titer of anti-insulin antibodies. At infectious diseases and tuberculosis, the product should be used only in combination with antibiotics or drugs for the treatment of tuberculosis.

Drug interactions:
If prednisolone is prescribed against the background of antidiabetic or anticoagulant drugs, then their dose must be adjusted.
At sharing Prednisolone and barbiturates should be used with caution in patients suffering from Addison's disease.
During pregnancy, especially in the first trimester, prednisolone should be prescribed with extreme caution.

Overdose:
Reports of acute toxic effects or death from glucocorticoid overdose are rare. In cases of overdose, there are no specific antidotes. Symptomatic therapy is carried out.

Prednisolone side effects:
With prolonged use, obesity, hirsutism (excessive hair growth in women, manifested by the growth of a beard, mustache, etc.), acne, menstrual irregularities, osteoporosis, Itsenko-Cushing symptom complex (obesity, accompanied by decreased sexual function, increased bone fragility due to increased release of adrenocorticotropic hormone from the pituitary gland), ulceration of the digestive tract, perforation of an unrecognized ulcer (the appearance of a through defect in the wall of the stomach or intestine at the site of the ulcer), hemorrhagic pancreatitis (inflammation of the pancreas, occurring with hemorrhage into its body), hyperglycemia (increased blood sugar levels) , decreased resistance to infections, increased blood clotting, mental disorders. When treatment is stopped, especially long-term, withdrawal syndrome may occur (a sharp deterioration in the patient’s condition after stopping taking the drug), adrenal insufficiency, or an exacerbation of the disease for which prednisolone was prescribed.

Release form:
Tablets containing 0.001; 0.005; 0.02 or 0.05 g of prednisolone in a pack of 100 pieces. Ampoules of 25 and 30 mg in 1 ml in a pack of 3 pcs. Ampoules with 1 ml of injection suspension containing prednisolone 25 or 50 mg, in a pack of 5, 10, 50, 100 and 1000 pcs. 0.5% ointment in tubes of 10 g. 0.5% ophthalmic suspension in a pack of 10 ml.

Synonyms:
Антизолон, Коделкортон, Кордекс, Дакортин, Декортин Н, Дигидрокортизол, Делта-Кортеф, Делтакортил, Делтастаб, Делтидрозол, Делтисилон, Гостакортин Н, Гиделтра, Гидрокортанцил, Мекортолон, Метакорталон, Метакортандролон, Меликортелон, Низолон, Паракортол, Прекорталон, Преднелан, Пренолон, Steran, Sgerolon, Ultracorten N, Tednisol, Sherizolon, Prednisolone-Darnitsa.

Storage conditions:
List B. In a place protected from light.
Dispensing conditions: by prescription.

Prednisolone composition:
International and chemical names: Prednisolonum; (pregnadiene-1,4-triol-11,17,21-dione-3,20 (or -dehydrocortisone);
basic physical and chemical properties: white tablets;
composition: 1 tablet contains 0.005 g of prednisolone;
excipients: milk sugar, potato starch, calcium stearate.

Additionally:
Manufacturers:
CJSC "Pharmaceutical Firm "Darnitsa", Kyiv, Ukraine;
RUE BelMedPreparaty, Minsk, Belarus;
Gedeon Richter, Hungary.

Attention!
Before using the medication "Prednisolone" you should consult your doctor.
The instructions are provided for informational purposes only. Prednisolone».

Prednisolone (in Latin - Prednisolon) is an anti-inflammatory drug that is used to treat children and adults. It is often a first-line drug of therapy.

Compound

Dosage active substance depends on the form of release:

1. Tablets can contain 1 and 5 mg of the main component. They also contain stearic acid, milk sugar, povidone, and starch.
2. The solution for intravenous administration per 1 ml contains 15 or 30 mg. The preparation includes water for injection, nicotinamide, sodium mitabisulfite and other substances as auxiliary components.
3. In drops the concentration is 0.5% (per 1 g - 5 mg).
4. The ointment consists of the following components: active substance (50 mg), glycerin, petroleum jelly, stearic acid and other components.

Release form

The product has several forms of release:

1. Ointment. Packaged in tubes of 10 and 15 g.
2. The tablets are white, round, flat on both sides, with a notch for division. Packing - contour blister pack contains 10 pcs., in one cardboard box There can be up to 10 blisters or a polymer jar containing from 20 to 60 tablets.
3. Lyophilisate (for preparing solution for injection). There are 5 ampoules in 1 cardboard box, placed in a blister pack.
4. Drops. Glass dropper bottle with a capacity of 5 ml, packed in a cardboard box.
5. The solution for injection is transparent, colorless or with a greenish-yellowish tint. In a cardboard package there are 3 ampoules of 1 ml each in a plastic tray.

Pharmacological action

Pharmacodynamics: the product has:

• anti-inflammatory;
• antiallergic;
• immunosuppressive;
• anti-shock properties.

A complex of a steroid hormone with a receptor is delivered to the cell nucleus, where it begins to interact with effector elements concentrated in areas of chromatin, resulting in a change in messenger RNA and proteins.

Artificial suppression of immunity leads to a decrease in the number of T-lymphocytes and their influence on B-lymphocytes, and accelerates the production of immunoglobulins.

The antiallergic effect is explained by inhibition of the production of allergy provocateurs and a decrease in the development of lymphoid tissue. The product is effective for rapid allergic reactions.

Accelerates the breakdown of proteins and reduces their amount in plasma, accelerates gluconeogenesis in the liver and ensures the formation of enzyme proteins, accelerates the synthesis of albumin in the liver and kidneys. Promotes the redistribution of fat, increases the formation of higher fatty acids.

The antishock effect is associated with a slowdown in the synthesis of platelet activation.

Pharmacokinetics:

• binds to plasma proteins by 90-95%;
• the biotransformation process occurs in the liver, small intestine, kidneys and bronchi;
• the half-life from the blood takes 3-4 hours, from tissues - 17-36 hours;
• excreted through the kidneys, penetrates the placental barrier.

ATX

According to the anatomical-therapeutic-chemical classification, it has the code H02AB06.

What is Prednisolone for?

The drug is used to relieve inflammation of varying severity and reduce body temperature. It is also used as a suppressant allergic reactions, which can threaten human life (Quincke's edema, anaphylactic shock), allergic rhinitis, dermatitis.

The medicine is administered for swelling of the brain that develops as a result of injury, for inflammation and progression of infection, after neurosurgery. It has a beneficial effect on severe burns of the gastrointestinal tract and respiratory tract, severe injuries, and is used for severe bronchial asthma, systemic lupus erythematosus, scleroderma, and rheumatoid arthritis.

Prescribed for adrenal hyperplasia, berylliosis, multiple sclerosis, acute hepatitis, hepatic coma and other pathologies. Used for inhalation for problems with the respiratory system, ophthalmology, and oncology.

How to take Prednisolone and how much?

The choice of drug form and treatment regimen depend on the pathology and general condition of the patient. The instructions for use must be strictly followed.

Use of tablets

Treatment with tablets is long-term, used when severe conditions.

During replacement therapy, 20-30 mg per day is prescribed for oral administration.

For nephrotic syndrome and rheumatic pathologies, the number of tablets increases. For mental disorders, high doses are prescribed in exceptional cases, treatment is carried out under constant medical supervision.

For children, the dose for treatment is 1-2 mg per 1 kg of weight, divided 4-6 times a day; to maintain the condition, 0.3-0.6 mg per 1 kg of weight is prescribed, with most or the entire dose taken in the morning.

Prednisolone in ampoules

Injections are given intramuscularly, through a vein or into a joint. The use of ampoules does not involve mixing the product with other medications in a syringe or dropper.

Drug dose:

1. For adults, 4-60 mg is administered intravenously or intramuscularly per day.
2. Children from 6 to 12 years old are given 25-25 mg per day; for children over 12 years old this dose is 25-50 mg. It is injected deep into the gluteal muscle and used strictly as prescribed by a doctor and under his supervision. The course of treatment and administration regimen are selected individually.
3. When diagnosed with Addison's disease, the dose for an adult is 4-60 mg intramuscularly or intravenously.
4. Ulcerative colitis is treated for 5-6 days with a dose of 8-12 ml per day; for severe Crohn's disease, the dose is from 10 to 13 ml per day, the course is 5-7 days.
5. In severe conditions, it is administered slowly intravenously (about 3 minutes) or through a dropper, the dose is 30-60 mg. If it is impossible to inject the drug through a vein, inject it intramuscularly deeply. The dose is increased individually, according to indications.
6. When administered intra-articularly for an adult, the dose is for large joints is 30 mg, for medium - 10-25 mg, for small - 5-10 mg. The procedure is carried out after 3 days, treatment - up to 3 weeks.

Ointment

The product is applied in a thin layer to the skin up to 3 times a day, lightly rubbed in. The course is chosen individually, depends on the disease and the effectiveness of treatment, lasts from 6 to 14 days, no more.

For children over one year of age, treatment lasts 3-7 days, and warming and fixing bandages should not be applied to the site where the ointment is applied, so as not to increase the absorption of corticosteroids.

Eye drops

The drug in the form of a 0.5% solution is injected into the eye 3 times a day, 1-2 drops. In acute conditions, the procedure is carried out every 2-4 hours. After eye surgery, the product is applied 3 or 5 days after surgery.

Before or after meals

The product is used during meals or after meals.

Morning or evening

Special instructions

Prescribed with caution for diabetes mellitus. For tuberculosis and other infections, it is prescribed with antibiotics or tuberculostatic agents.

During treatment it is necessary to monitor blood pressure and vision, monitor glucose levels in the blood and urine, and test feces for occult blood. With sudden withdrawal, nausea, lethargy, and anorexia may develop.

Use during pregnancy and lactation

During pregnancy, especially in the first trimester, the drug is prescribed for health reasons, when the benefits of treatment outweigh the harm from using the drug.

It is best to start feeding 4 hours after taking the drug.

Can Prednisolone be given to children?

There are no age restrictions for use, but the drug can negatively affect some processes occurring in the child’s body, therefore it is prescribed strictly according to indications and under the constant supervision of a doctor.

Use in old age

In old age, glucocorticosteroids can have an effect on the body negative impact, therefore, you need to take the drug with caution and strictly according to the recommendations of doctors.

Use for renal impairment

Not used to treat patients with severe renal failure.

Use for liver dysfunction

Prohibited in case of severe liver failure.

Alcohol compatibility

For one-time use alcoholic drinks During treatment there will be no negative effect on the body, but the systematic combination of alcohol and glucocorticoid treatment can lead to serious consequences.

Impact on the ability to drive vehicles and complex mechanisms

The drug sometimes causes dizziness and other side effects, so it should be taken with caution when driving or driving complex mechanisms, where required fast response and concentration.

How to reduce the dosage of Prednisolone

The dosage of the drug is reduced slowly, according to the scheme chosen by the doctor. If you abruptly stop using the drug, the disease may recur.

How long does it take for Prednisolone to work?

The drug in tablets begins to act 90 minutes after administration for 18-36 hours. When administered intramuscularly, the medicine acts after 15 minutes, and when administered intravenously, after 3 minutes.

The product in the form of ointment and drops has an effect immediately after use.

How is the drug harmful?

The drug is a systemic drug, therefore it affects the entire body and, along with the benefits, can have a negative effect on organs and systems. Hormonal remedy When taken continuously, it reduces immunity, so it is prescribed in short courses.

Prednisolone withdrawal regimen

When reducing the dose, it is necessary to take into account the results of blood tests. The withdrawal of the drug occurs gradually. After the decline daily dose up to 10 mg per day, the reduction should be carried out by less than 1 mg per month. This could be 1 mg every 2 months.

The initial dose is reduced by 2.5 mg every month or to 10 mg per day every 2 weeks, then by 1 mg every 6-8 weeks until complete cessation of treatment.

Contraindications

Does not apply in the following cases:

1. At hypersensitivity to the substances included in the product.
2. Diseases of the stomach and duodenum.
3. For osteoporosis.
4. Itsenko-Cushing's disease.
5. Thromboembolism.
6. Development of renal failure, nephrourolithiasis.
7. Development of hypoalbuminemia.
8. Hypertension.
9. Internal and external viral infections.
10. Diabetes mellitus.
11. Vaccination of any kind.
12. Systemic mycosis.
13. Tuberculosis is active and in latent form.
14. Cataract and glaucoma.
15. Progressive mental illnesses, depressive states.
16. Herpes.
17. Syphilis.
18. Pregnancy and lactation period.
19. Infections at the injection site during intra-articular injections.

Side effects

The occurrence of side effects depends on the duration of the course of treatment, the dose and regimen of the drug.

Negative consequences can occur from all organs and systems. A person’s blood pressure may increase; due to the drug’s effect on glucose production, obese patients have problems losing weight and diabetes mellitus progresses.

Numerous digestive problems, pancreatitis, internal bleeding. Arrhythmia and bradycardia develop, after a heart attack the area of ​​necrosis increases, the growth of scar tissue slows down, which can lead to heart rupture. Nervous system disorders, euphoria, hallucinations, psychoses occur, intracranial pressure increases, insomnia, convulsions, severe headaches, and problems with the cerebellum appear.

Problems with the organs of vision arise: intraocular pressure increases, which may cause damage to the optic nerve; cataracts and secondary infections may develop. In children, the formation of the musculoskeletal system is disrupted; in adults, osteoporosis and other problems with bones and cartilage develop.

Numerous rashes may appear on the skin, healing of damage slows down, and candidiasis develops. Night urination becomes more frequent and urolithiasis appears.

Full list adverse reactions you need to ask your doctor.

Overdose

In case of overdose, the manifestation of side effects increases.

Drug interactions

Combining medications can have a negative effect on the body.

When treating, the following conditions must be taken into account:

1. Ephedrine, Phenobarbital and Theophylline reduce the concentration of the active substance. Combination with diuretics accelerates the removal of potassium from the body. Sodium-containing drugs increase blood pressure and provoke the formation of edema.
2. TO heavy bleeding and ulcers in the gastrointestinal tract can be caused by combination with anticoagulants and thrombolytics. Indomethacin increases side effects.
3. The drug enhances the negative effect of Paracetamol on the liver and reduces the effect of taking insulin.
4. Intraocular pressure increases when used together with antidepressants and nitrates.
5. When using a drug to reduce adrenal activity, an increase in the dose of the active substance may be required.
6. Neuroleptics provoke the development of cataracts.
7. Vaccines containing live viruses increase the risk of contracting viral infections.

When treating, the doctor takes everything into account possible risks from combining drugs.

Analogues

The following analogues have a general structure:

• Metypred, Dexamed, Dexamethasone;
• Betamethasone, Diprospan, Maxidex;
• Flosterone, Kenalog, Hydrocortisone;
• Suprastin.

PREDNISOONE is a multifunctional hormonal drug.