Acc instructions. Important information for patients. Powder for preparing solution

Many pathologies respiratory organs accompanied painful cough. Moreover, regardless of whether it is dry or wet, the patient tries to get rid of it as soon as possible. unpleasant symptom. In pharmacies you can find many medicines that will help short term cure cough, these include ACC. The medication can be prescribed for both dry and productive cough. ACC with a dry cough increases the volume of mucus produced and promotes its removal, and with a wet cough it helps to easily remove mucus from the respiratory organs.

General characteristics of the drug

The pharmaceutical industry produces the drug ACC in several doses and forms. There is also a long-acting drug that cannot be taken more than 2 times a day.. In pharmacies you can find the following forms of the drug:

  • soluble cough tablets;
  • solution for inhalation;
  • powder, which when diluted in water produces a drink;
  • sweet syrup. This form of medication is convenient to prescribe for the treatment of cough in a small child;
  • solution for intravenous and intramuscular injections.

The active component of these dosage forms is acetylcysteine. In addition, each type of drug differs in some auxiliary components. Thus, the granules, among other things, contain citrus flavoring, the soluble tablets contain blackberry flavoring, and the syrup contains cherry flavoring.

ACC can be prescribed for both non-productive and wet coughs. The acetylcysteine ​​contained in the drug promotes the rapid removal of sputum from the bronchi and lungs. When taking ACC, the patient must drink a lot, in this case the effect of the drug is enhanced, and the sputum is cleared well.

The effect of this drug has not yet been fully studied.. Acetylcysteine ​​has a pronounced mucolytic, expectorant and antioxidant effect. Recent studies have shown that this substance can effectively remove toxic substances from the body. However, ACC is most often used for wet and dry coughs to facilitate sputum discharge. This medication is able to thin thick mucus and then gently remove it from the respiratory organs. Among other things, acetylcysteine ​​has a mild anti-inflammatory effect.

ACC can be prescribed for the treatment of both adults and children of various ages. In the latter case, the required dose is calculated by the attending physician.

Indications

When taking ACC for a cough, note positive result possible just an hour after the starting dose. Most often, doctors prescribe granules for making a solution and original soluble tablets to patients with cough. Such medications are considered more convenient to use. You can start taking one or another form of the drug only on the recommendation of a doctor, since they have different effects on the respiratory organs.

Syrup with acetylcysteine ​​will quickly help eliminate cough when chronic pathologies lungs, and special solution for inhalation it is very effective for laryngotracheitis.

The drug is prescribed by doctors for pathologies of the respiratory organs, which are accompanied by different types cough, namely with:

  • bacterial and viral pneumonia;
  • bronchitis of various types;
  • cystic fibrosis and asthma;
  • various types of sinusitis;
  • otitis.

ACC for bronchitis and pneumonia is prescribed only as part of complex therapy. In this case, in addition to ACC, antibiotics and medications of other groups are often prescribed.

Most often, ACC is prescribed for productive wet cough. This medication can also be used for unproductive coughs, but only if the patient has already taken medications to thin out too thick sputum. The viscous mucus in the respiratory organs has already liquefied, and the cough has become productive. Otherwise, ACC will have no effect on an exhausting dry cough.

For dry coughs, people are usually prescribed ACC Long, but only in combination with drugs that help thin the mucus.

When prescribing ACC for children with a dry cough, you should immediately tell parents that the treatment will give a noticeable result if followed drinking regime, and in addition to this drug, the child will take syrups based on licorice root or medications containing ambroxol.

Contraindications

Not all cases can be treated various types cough ACC. It is contraindicated to take the medication if:

  • pulmonary hemorrhages;
  • coughing up sputum mixed with blood;
  • chronic renal failure;
  • septic;
  • hepatitis;
  • special sensitivity to the ingredients in the drug.

During pregnancy and breastfeeding, the drug can be prescribed only in special cases when there is no alternative. In this case, the expected benefit for the expectant mother should be higher than possible harm for a child.

Side effects

ACC may have certain side effects. When treated with this medication, there is a high likelihood of the following disorders:

The annotation to the ACC Long contains information that there may be allergic reactions that look like skin rash.

How to take the medicine

The dosage of ACC depends not only on the person’s age and the severity of the disease, but also on the type of drug. All types of ACC have a certain daily dosage.

ACC 100 can be given to children almost from birth. Children under 2 years of age are prescribed a medicine of 50 mg three times a day. A soluble 100 mg tablet is divided in half and then diluted in 0.5 cups of water.

From 2 to 5 years old, the child drinks medicine 4 times a day, single dose is 100 mg. Children over 6 years old drink ACC 200 three times a day.

ACC Long can be prescribed to patients over 14 years of age. Daily dose equals 600 mg, it is drunk at a time. The effervescent tablet is dissolved in water and drunk immediately after meals.

You need to understand that if the prepared medicine could not be drunk for some reason, then it should be taken no later than a couple of hours after dilution. If more time has passed, then prepare a fresh medicinal drink.

ACC 200 can only be taken in the form aqueous solution. It is prescribed to children who are already six years old. You can consume 2 sachets per day, which are previously diluted in warm water. Adolescents over 14 years of age and adult patients consume a whole sachet of pre-diluted drug three times a day.

The powder for the solution can be diluted in water, iced tea, your favorite juice or cooled compote. The powder for preparing the solution is poured clean water until the mark is marked on the bottle, and then mix well, after closing the lid. After taking the medicine, be sure to drink enough water or other drink, in which case the effectiveness of the treatment will be higher.

If ACC does not help with cough at all for 4-5 days, then you need to consult a doctor; the dose may need to be adjusted. The minimum course of treatment is 5 days, but if necessary, therapy can last up to six months.

Infants can dilute ACC in water and then give it through a bottle with a nipple.

Features of treatment for pregnant women

In women, during the period of bearing a child, immunity is greatly reduced, so the frequency of diseases respiratory infections increases. To treat pregnant women, doctors select medications that will not provide negative impact for the fruit. Action of ACC It has not yet been fully studied for pregnant women, but based on the fact that it is prescribed to infants, expectant mothers can also take this medicine. The dose of medication for this group of patients is determined by the doctor.

If alarming symptoms appear while taking the drug, stop treatment and contact a medical facility.

ACC is a highly effective remedy for wet and dry coughs, which can also be purchased at low price. The form and dose of the medicine is selected by the doctor individually, but more often they prescribe soluble tablets and packaged powder for preparing a healing drink.

Mucolytic drug.

Drug: ACC ®
Active substance: acetylcysteine
ATX code: R05CB01
KFG: Mucolytic drug
Reg. number: P No. 015474/01
Registration date: 01/13/05
Owner reg. cert.: HEXAL AG (Germany)

DOSAGE FORM, COMPOSITION AND PACKAGING

Granules for the preparation of solution for oral administration (orange) white, without agglomerates and mechanical impurities, with the smell of orange.

Excipients:ascorbic acid, saccharin, sucrose, orange flavor.

Granules for the preparation of solution for oral administration white, homogeneous, no more than 1.5 mm in size, without agglomerates and mechanical impurities, with the smell of lemon and honey.

Excipients: ascorbic acid, saccharin, sucrose, honey and lemon flavors.

3 g - sachets (6) - cardboard packs.
3 g - sachets (10) - cardboard packs.
3 g - sachets (20) - cardboard packs.

ACC ® 100

Effervescent tablets white, round, flat, with the smell of blackberries.

Excipients:







ACC ® 200

Effervescent tablets white, round, flat, scored, with the smell of blackberries.

Excipients: ascorbic acid, citric acid anhydride, lactose anhydride, mannitol, sodium citrate, sodium bicarbonate, saccharin, blackberry flavor.

4 pcs. - strips (15) - cardboard boxes.
20 pcs. - aluminum tubes (1) - cardboard boxes.
20 pcs. - plastic tubes (1) - cardboard boxes.
25 pcs. - aluminum tubes (2) - cardboard boxes.
25 pcs. - plastic tubes (2) - cardboard boxes.
25 pcs. - aluminum tubes (4) - cardboard boxes.
25 pcs. - plastic tubes (4) - cardboard boxes.

ACC ® LONG

Effervescent tablets white, round, with a smooth surface, scored, with the smell of blackberries.

Excipients:citric acid anhydrous, sodium bicarbonate, sodium carbonate anhydrous, mannitol, lactose anhydrous, ascorbic acid, sodium cyclamate, sodium saccharinate dihydrate, sodium citrate dihydrate, blackberry flavoring "B".

6 pcs. - polypropylene tubes (1) - cardboard packs.
10 pcs. - polypropylene tubes (1) - cardboard packs.
20 pcs. - polypropylene tubes (1) - cardboard packs.

The description of the drug is based on the officially approved instructions for use.

PHARMACOLOGICAL ACTION

Mucolytic drug. The presence of sulfhydryl groups in the structure of the acetylcysteine ​​molecule promotes the rupture of disulfide bonds of acidic mucopolysaccharides of sputum, which leads to a decrease in the viscosity of mucus. The drug remains active in the presence of purulent sputum.

At prophylactic use acetylcysteine ​​there is a decrease in the frequency and severity of exacerbations in patients with chronic bronchitis and cystic fibrosis.

PHARMACOKINETICS

Pharmacokinetic data ACC drug not provided.

INDICATIONS

Diseases of the respiratory system, accompanied by increased formation of viscous mucus that is difficult to separate (acute and chronic bronchitis, obstructive bronchitis, pneumonia, bronchiectasis, bronchial asthma, bronchiolitis, cystic fibrosis, laryngitis);

Spicy and chronic sinusitis;

Otitis media

DOSING REGIME

Adults and teenagers over 14 years old it is recommended to prescribe the drug 200 mg 2-3 times a day (ACC 100 or ACC 200), or 200 mg 3 times a day (ACC in the form of granules for the preparation of a solution for oral administration 200 mg) or 600 mg 1 time / day (ACC LONG or ACC in the form of granules for the preparation of a solution for oral administration 600 mg).

Children aged 2 to 5 years The drug is recommended to be taken 100 mg 2-3 times a day (ACC 100 or ACC 200).

At cystic fibrosischildren over 6 years old the drug is recommended to be taken 200 mg 3 times a day (ACC 100, ACC 200 or ACC in the form of granules for the preparation of an oral solution of 200 mg). Children aged 2 to 6 years- 100 mg 4 times/day (ACC 100 or ACC 200). Patients with body weight more than 30 kg for cystic fibrosis, if necessary, you can increase the dose to 800 mg/day.

At sudden short-term colds Duration of treatment is 5-7 days. At chronic bronchitis and cystic fibrosis the drug should be used for a longer period of time to prevent infections.

The drug should be taken after meals. Additional reception liquid enhances the mucolytic effect of the drug.

Effervescent tablets (ACC 100 and ACC 200) should be dissolved in 1/2 glass of water, effervescent tablets (ACC LONG) should be dissolved in 1 glass of water. Take immediately after dissolution, in exceptional cases you can leave it ready solution for 2 hours

Granules for preparing a hot drink (1 sachet) are dissolved with stirring in 1 glass hot water and drink it hot if possible. If necessary, you can leave the prepared solution for 3 hours.

Granules for oral solution (orange scent) should be dissolved in water, juice or iced tea and taken after meals.

SIDE EFFECTS

From the side of the central nervous system: rarely - headaches, tinnitus.

From the outside digestive system: rarely - stomatitis; in some cases - diarrhea, vomiting, heartburn and nausea.

From the outside cardiovascular system: in some cases - a drop in blood pressure, tachycardia.

From the respiratory system: in isolated cases - the development of pulmonary hemorrhage as a manifestation of a hypersensitivity reaction.

Allergic reactions: in isolated cases - bronchospasm (mainly in patients with a hyperreactive bronchial system with bronchial asthma), skin rash, itching and urticaria.

CONTRAINDICATIONS

Gastric ulcer and duodenum in the acute phase;

Hemoptysis;

Pulmonary hemorrhage;

Pregnancy;

Lactation period ( breastfeeding);

Children under 6 years of age (the drug is in the form of granules for the preparation of a solution for oral administration 200 mg);

Children under 14 years of age (dosage forms containing acetylcysteine ​​600 mg);

Hypersensitivity to acetylcysteine ​​and other components of the drug.

WITH caution the drug should be used in patients with varicose veins of the esophagus, with increased risk development of pulmonary hemorrhage and hemoptysis, with bronchial asthma, diseases of the adrenal glands, liver and/or kidney failure.

ACC LONG should not be prescribed to children under 14 years of age. In this category of patients, it is recommended to use dosage forms of the drug for oral administration with more low content acetylcysteine.

PREGNANCY AND LACTATION

Because of insufficient quantity According to these data, the use of the drug during pregnancy and lactation is possible only in cases where the expected benefit to the mother outweighs the potential risk to the fetus or child.

SPECIAL INSTRUCTIONS

For bronchial asthma and obstructive bronchitis, acetylcysteine ​​should be prescribed with caution under systematic monitoring of bronchial patency.

During development side effects the drug should be discontinued.

When dissolving the drug, it is necessary to use glass containers and avoid contact with metals, rubber, oxygen, and easily oxidized substances.

1 tablet effervescent ACC 100 and ACC 200 corresponds to 0.006 XE.

1 effervescent tablet ACC LONG corresponds to 0.01 XE.

ACC (in the form of granules for the preparation of an oral solution of 200 mg) corresponds to 0.21 XE, ACC (in the form of granules for the preparation of an oral solution of 600 mg) - 0.17 XE.

ACC (in granules for the preparation of a solution for oral administration 100 mg and 200 mg with the scent of orange) 100 mg corresponds to 0.24 XE, 200 mg - 0.23 XE.

Use in pediatrics

OVERDOSE

Symptoms: Possible diarrhea, vomiting, stomach pain, heartburn, nausea.

Treatment: carrying out symptomatic therapy.

DRUG INTERACTIONS

With the simultaneous use of acetylcysteine ​​and antitussives, dangerous mucus stagnation may occur due to suppression of the cough reflex (use the combination with caution).

When taking acetylcysteine ​​and nitroglycerin simultaneously, the vasodilatory effect of nitroglycerin may be enhanced.

There is a synergism between acetylcysteine ​​and bronchodilators.

Pharmaceutical interactions

Acetylcysteine ​​is pharmaceutically incompatible with antibiotics (penicillins, cephalosporins, erythromycin, tetracycline and amphotericin B) and proteolytic enzymes.

Acetylcysteine ​​reduces the absorption of cephalosporins, penicillins and tetracycline, so they should be taken orally no earlier than 2 hours after taking acetylcysteine.

When acetylcysteine ​​comes into contact with metals and rubber, sulfides with a characteristic odor are formed.

CONDITIONS OF VACATION FROM PHARMACIES

The drug is approved for use as an over-the-counter product.

CONDITIONS AND DURATION OF STORAGE

The drug should be stored in a dry place, out of reach of children, at a temperature not exceeding 25°C. Shelf life - 3 years, shelf life of granules for preparing an oral solution (orange scent) - 4 years.

ACC LONG should be stored in a dry place, protected from light, out of reach of children, at a temperature not exceeding 30°C. Shelf life - 3 years.

After taking the tablet, the tube should be tightly closed.

You are a fairly active person who cares and thinks about your respiratory system and health in general, continue to exercise, lead healthy image life and your body will delight you throughout your life. But do not forget to undergo examinations on time, maintain your immunity, this is very important, do not overcool, avoid severe physical and strong emotional overload. Try to minimize contact with sick people; if forced contact, do not forget about protective equipment (mask, washing your hands and face, clearing your respiratory tract).

  • It's time to think about what you are doing wrong...

    You are at risk, you should think about your lifestyle and start taking care of yourself. Physical education is required, or even better, start playing sports, choose the sport that you like most and turn it into a hobby (dancing, cycling, gym or just try to walk more). Do not forget to treat colds and flu promptly, they can lead to complications in the lungs. Be sure to work on your immunity, strengthen yourself, be in nature as often as possible and fresh air. Do not forget to undergo scheduled annual examinations, treat lung diseases initial stages much simpler than in a neglected state. Avoid emotional and physical overload; if possible, eliminate or minimize smoking or contact with smokers.

  • It's time to sound the alarm!

    You are completely irresponsible about your health, thereby destroying the functioning of your lungs and bronchi, have pity on them! If you want to live a long time, you need to radically change your entire attitude towards your body. First of all, get examined by such specialists as a therapist and pulmonologist, you need to take radical measures otherwise everything may end badly for you. Follow all the doctors' recommendations, radically change your life, perhaps you should change your job or even your place of residence, completely eliminate smoking and alcohol from your life, and make contact with people who have such bad habits to a minimum, toughen up, strengthen your immune system, spend time in the fresh air as often as possible. Avoid emotional and physical overload. Completely eliminate all aggressive products from everyday use and replace them with natural ones. natural remedies. Do not forget to do wet cleaning and ventilation of the room at home.

  • There are two types of cough: wet, accompanied by the release of sputum, and dry, which occurs with allergies and colds. Getting rid of an unpleasant ailment is not difficult; you can find many effective medications in pharmacies. good and quality product for cough, the mucolytic complex ACC, produced by the German company, is considered pharmaceutical company HEXAL AG. The drug helps to quickly and easily clear the airways of mucus and is suitable for the treatment of both wet and dry coughs in adults and children.

    Pharmaceutical forms

    ACC is a highly effective and popular antitussive complex, including liquid-soluble tablets and powders. The medicine is a strong mucolytic, improves lung function and dilutes the purulent mucus accumulated in the bronchial trunks.

    The drug also has an anti-inflammatory effect and stimulates expectoration. The drug is sold in different pharmaceutical forms, suitable for both adults and children:

    • tablets for dissolution, 100 mg, 200 mg;
    • ACC Long effervescent tablets;
    • granulated powder for syrup, 200 mg, 600 mg;
    • powder for sweet solution, 100 mg, 200 mg.

    Chemical composition

    The drug is remarkably helpful in getting rid of dry and wet coughs. During treatment, you should drink enough fluid, this is important to speed up the effect of the medicine.

    Active substance – sodium salt acetylcysteine, it has a beneficial effect on the mucous membranes of the respiratory tract, quickly clearing the lungs of mucus.

    Each dosage form includes your own set additional components. Syrup granules contain:

    • sodium benzoic acid or preservative E211,
    • croscarmellose or stabilizer E468,
    • caustic soda, disodium edetate,
    • saccharinate, methylparaben or preservative E218.

    Powder for sweet solution contains sucrose, saccharin, ascorbic acid. The tablets contain ascorbic acid, baking soda, lactose anhydrous, sodium citric acid or food additive E331, anhydrous citric acid, saccharin, osmotic diuretic D-Mannitol.

    Indications for use

    Judging by the reviews of people suffering from cough, it is most simple and convenient to use tablets and ACC syrup. But which one pharmaceutical form the patient should take the drug, determines only medical specialist. The fact is that tablets and solutions have different effects on the body.

    The syrup is intended to relieve the symptoms of chronic diseases of the pulmonary system, the solution is intended to treat acute inflammatory reactions that make breathing difficult. Tablets are indicated for wet cough caused by the following pathologies of the respiratory system:

    • bronchitis;
    • bronchial asthma;
    • sinusitis;
    • otitis media;
    • cystic fibrosis;
    • pneumonia.

    The principle of action of the drug

    Slime in respiratory tract present constantly, is a reliable cleanser and protector. Every person, waking up in the morning, sometimes feels that his nasopharynx, trachea and bronchi are filled with a viscous mass. During an acute respiratory disease mucus is formed in excess.

    Its main task is to remove pathogenic microorganisms from the respiratory system. Sometimes infectious diseases accompanied by the accumulation of very thick sputum in the respiratory tract, which cannot be coughed up. In this situation, the ACC complex is used.

    The drug thins mucus, relieves inflammation, and stimulates expectoration. Main active substance breaks the disulfide contacts of sputum proteoglycans, as a result, the mucus becomes more fluid and can be coughed up freely.

    Therefore, the drug is usually prescribed for a wet cough. Doctors rarely prescribe ACC tablets and solutions for dry coughs; they are combined with other mucolytic medications. Dry cough is treated preferentially effervescent tablets ACC Long, but only as part of complex therapy.

    The effect of the medicine is noticed an hour after administration. Spent medicinal substances leaves the body along with urine, less often with feces. The rate of elimination of drug residues depends on the health of the urinary system. If kidney function is impaired, drug particles can remain stuck in the body for a long time. Some patients note that their cough gets worse when taking the drug. No need to worry: this normal phenomenon, indicating recovery. Over time, the cough weakens and then disappears altogether.

    Contraindications for use

    ACC is considered a highly effective and safe complex for the treatment of cough, reviews about it pharmaceutical product extremely positive. The medicine is suitable for both old people and children. However, not all sick people are allowed to take the drug. You should not use it if you have the following pathologies and characteristics of the body:

    • kidney dysfunction;
    • peptic ulcer;
    • hematopoe;
    • hepatitis;
    • pregnancy;
    • lactation;
    • intolerance to substances contained in the medication.

    The dosage and therapeutic course are determined by the attending physician; self-medication is under no circumstances allowed. The ACC complex is often prescribed not for therapy, but to prevent the occurrence of cough.

    It is impossible to predict how the medicine will affect the body. Some people do not experience any side effects, for others it appears allergic rash. Allergies are usually observed when consuming ACC tablets 200 mg, ACC Long. In case of an overdose of the drug, the following ailments occur:

    • migraine;
    • nausea;
    • increased heart rate;
    • lowering blood pressure;
    • belching;
    • buzzing in the head;
    • stomatitis;
    • profuse vomiting.

    Instructions for use

    When doctors prescribe an ACC complex, patients immediately have a question about which cough is best to take the medicine for.

    The drug is intended to get rid of wet cough. Many people note that taking ACC tablets for a dry cough without auxiliary mucolytic medications does not improve, but worsens the condition.

    You should also carefully observe the dosage; it is different for children and adults. Soluble tablets Even infants can take ACC for cough.

    • Children under two years old take the medicine three times a day, 50 mg,
    • children from two to five years old - 100 mg four times a day,
    • children from the age of five - 600 mg three times a day.

    Effervescent tablets can only be consumed from the age of fourteen. Daily norm 600 mg should be drunk at a time. The tablet is immersed in water, dissolves in it with a hiss, and the resulting medicine is drunk after lunch.

    If you can’t drink the whole solution at once, you can divide it into two portions, and drink the second part after an hour, maximum two. The prepared solution cannot be stored for a long time; it quickly deteriorates and loses its medicinal qualities.

    ACC sweet solution powder is intended for children from the age of six and adults. One sachet of medicine is poured into a mug and poured warm water, is mixed. Children drink the suspension twice a day, schoolchildren and adults – three times.

    The powder is added not only to water, but also to fruit drinks, compotes, and slightly warmed juices. Granulated powder for syrup is poured with warm water up to the line on the bottle. For the syrup to work better, it is advisable to drink it with a large number liquids. The minimum course of treatment is five days, but if the cough is advanced, then therapy can last up to six months with interruptions.

    Analogues of the ACC complex are cheaper

    If a sick person has individual intolerance components of the drug, then he should take a certain analogue of the ACC complex. The most famous mucolytic medicines that help overcome cough are:

    Average prices for different dosage forms

    1. Soluble tablets, 100 mg – 245 rubles.
    2. Soluble tablets, 200 mg – 265 rubles.
    3. Effervescent tablets, 600 mg – 360 rubles.
    4. Powder, 100 mg – 130 rubles.
    5. Powder, 200 mg – 125 rubles.
    6. Granules for solution, 600 mg – 140 rubles.
    7. Children's syrup, 100 ml – 245 rubles.
    8. Children's syrup, 200 ml – 320 rubles.

    Storage rules and expiration date

    The shelf life of the ACC complex is four years. After the expiration date, the spoiled drug must be disposed of. The medicine should be stored in a child-proof first aid kit at an air temperature below +25°C. The pharmacy chain sells the medicine without a prescription.

    Instructions
    by application medicinal product for medical use

    Registration number:

    P N015473/01-180914

    Trade name of the drug:

    International nonproprietary name:

    acetylcysteine.

    Dosage form:

    effervescent tablets.

    Compound:

    1 effervescent tablet contains:
    active ingredient: acetylcysteine ​​– 200.00 mg; excipients: anhydrous citric acid – 558.50 mg; sodium bicarbonate – 200.00 mg; sodium carbonate anhydrous – 100.00 mg; mannitol – 60.00 mg; anhydrous lactose – 70.00 mg; ascorbic acid – 25.00 mg; sodium saccharinate – 6.00 mg; sodium citrate – 0.50 mg; blackberry flavor “B” – 20.00 mg.

    Description: round, flat-cylindrical, white tablets with a score on one side, with a blackberry flavor. There may be a faint sulfuric odor.
    Reconstituted solution: colorless transparent solution with the smell of blackberries. There may be a faint sulfuric odor.

    ATX code: R05СВ01.

    Pharmacological properties

    Pharmacodynamics
    Acetylcysteine ​​is a derivative of the amino acid cysteine. Has a mucolytic effect, facilitates the discharge of sputum due to its direct effect on rheological properties sputum. The action is due to the ability to break the disulfide bonds of mucopolysaccharide chains and cause depolymerization of sputum mucoproteins, which leads to a decrease in sputum viscosity. The drug remains active in the presence of purulent sputum.
    It has an antioxidant effect based on the ability of its reactive sulfhydryl groups (SH groups) to bind to oxidative radicals and thus neutralize them.
    In addition, acetylcysteine ​​promotes the synthesis of glutathione, important component antioxidant system and chemical detoxification of the body. The antioxidant effect of acetylcysteine ​​increases the protection of cells from the damaging effects of free radical oxidation, which is characteristic of intense inflammatory reaction.
    With the prophylactic use of acetylcysteine, there is a decrease in the frequency and severity of exacerbations of bacterial etiology in patients with chronic bronchitis and cystic fibrosis.

    Pharmacokinetics
    Absorption is high. They are quickly metabolized in the liver to form a pharmacologically active metabolite - cysteine, as well as diacetylcysteine, cystine and mixed disulfides. Bioavailability when taken orally is 10% (due to the presence of a pronounced “first pass” effect through the liver). The time to reach the maximum concentration (Cmax) in the blood plasma is 1-3 hours. The connection with blood plasma proteins is 50%. Excreted by the kidneys in the form of inactive metabolites (inorganic sulfates, diacetylcysteine).
    The half-life (T1/2) is about 1 hour, liver dysfunction leads to an extension of T1/2 to 8 hours. Penetrates the placental barrier.
    Data on the ability of acetylcysteine ​​to penetrate the blood-brain barrier and be excreted from breast milk are missing.

    Indications for use

    Respiratory diseases accompanied by the formation of viscous, difficult to separate sputum:
    acute and chronic bronchitis, obstructive bronchitis;
    tracheitis, laryngotracheitis;
    pneumonia;
    lung abscess;
    bronchiectasis, bronchial asthma, chronic obstructive disease lungs (COPD), bronchiolitis;
    cystic fibrosis;
    Acute and chronic sinusitis, inflammation of the middle ear (otitis media).

    Contraindications:

    Hypersensitivity to acetylcysteine ​​or other components of the drug;
    peptic ulcer of the stomach and duodenum in the acute stage;
    pregnancy;
    breastfeeding period;
    hemoptysis, pulmonary hemorrhage;
    lactase deficiency, lactose intolerance, glucose-galactose malabsorption;
    childhood up to 2 years (for this dosage form).

    With caution: history of gastric and duodenal ulcers, bronchial asthma, obstructive bronchitis, hepatic and/or renal failure, histamine intolerance (should be avoided long-term use drug, because acetylcysteine ​​affects histamine metabolism and may lead to signs of intolerance such as headache, vasomotor rhinitis, itching), varicose veins esophageal veins, adrenal gland diseases, arterial hypertension.

    Use during pregnancy and breastfeeding

    Data on the use of acetylcysteine ​​during pregnancy and breastfeeding are limited, therefore the use of the drug during pregnancy is contraindicated. If it is necessary to use the drug during breastfeeding, the issue of stopping it should be decided.

    Directions for use and doses

    Inside, after eating.
    Effervescent tablets should be dissolved in one glass of water. The tablets should be taken immediately after dissolution; in exceptional cases, the ready-to-use solution can be left for 2 hours. Additional fluid intake enhances the mucolytic effect of the drug. For short-term colds, the duration of use is 5-7 days. At chronic bronchitis and cystic fibrosis, the drug should be taken more long time to achieve a preventive effect against infections.
    In the absence of other prescriptions, it is recommended to adhere to the following dosages:
    Mucolytic therapy:
    adults and children over 14 years old: 1 effervescent tablet 2-3 times a day (400-600 mg);
    children from 6 to 14 years old: 1 effervescent tablet 2 times a day (400 mg);
    children from 2 to 6 years old: 1/2 effervescent tablet 2-3 times a day (200-300 mg).
    Cystic fibrosis:
    children from 2 to 6 years old: 1/2 effervescent tablet 4 times a day (400 mg);
    children over 6 years old: 1 effervescent tablet 3 times a day (600 mg).

    Side effect

    According to World Organization health (WHO) unwanted effects classified according to their frequency of development as follows: very often (≥ 1/10), often (≥1/100,<1/10), нечасто (≥1/1000, <1/100), редко (≥1/10000, <1/1000) и очень редко (<1/10000); частота неизвестна (частоту возникновения явлений нельзя определить на основании имеющихся данных).
    Allergic reactions
    infrequently: skin itching, rash, exanthema, urticaria, angioedema, decreased blood pressure, tachycardia;
    very rarely: anaphylactic reactions up to anaphylactic shock, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome).
    From the respiratory system
    rarely: shortness of breath, bronchospasm (mainly in patients with bronchial hyperreactivity in bronchial asthma).
    From the gastrointestinal tract
    infrequently: stomatitis, abdominal pain, nausea, vomiting, diarrhea, heartburn, dyspepsia.
    Sensory disorders
    infrequently: tinnitus.
    Others
    infrequently: headache, fever, isolated reports of bleeding due to a hypersensitivity reaction, decreased platelet aggregation.

    Overdose

    Symptoms: In case of an erroneous or intentional overdose, phenomena such as diarrhea, vomiting, stomach pain, heartburn and nausea are observed.
    Treatment: symptomatic.

    Interaction with other drugs

    With the simultaneous use of acetylcysteine ​​and antitussives due to suppression of the cough reflex, sputum stagnation may occur.
    When used simultaneously with antibiotics for oral administration (penicillins, tetracyclines, cephalosporins, etc.) they may interact with the thiol group of acetylcysteine, which can lead to a decrease in their antibacterial activity. Therefore, the interval between taking antibiotics and acetylcysteine ​​should be at least 2 hours (except for cefixime and loracarbene).
    Simultaneous use with vasodilating agents And nitroglycerin may lead to increased vasodilatory effects.

    Special instructions

    Instructions for patients with diabetes mellitus
    1 effervescent tablet corresponds to 0.006 XE. When working with the drug, you must use glass containers and avoid contact with metals, rubber, oxygen, and easily oxidized substances.
    Cases of severe allergic reactions such as Stevens-Johnson syndrome and Lyell's syndrome have been very rarely reported with the use of acetylcysteine. If changes occur in the skin and mucous membranes, you should immediately consult a doctor and stop taking the drug.
    In patients with bronchial asthma and obstructive bronchitis, acetylcysteine ​​should be prescribed with caution under systemic monitoring of bronchial patency.
    You should not take the drug immediately before bedtime (it is recommended to take the drug before 18.00).

    Impact on the ability to drive vehicles and machinery

    There is no data on the negative effect of the drug ACC ® 200 in recommended doses on the ability to drive vehicles or use machinery.

    Special precautions when disposing of unused medicinal product

    There is no need for special precautions when disposing of unused ACC ® 200.
    Close the tube tightly after taking the tablet!

    Release form

    When packaging Hermes Pharma Ges.m.b.H., Austria:
    Primary packaging
    20 or 25 effervescent tablets in a plastic tube.
    Secondary packaging
    1 tube of 20 effervescent tablets or 2 or 4 tubes of 25 effervescent tablets along with instructions for use in a cardboard box.
    When packaging Hermes Arzneimittel GmbH, Germany
    Primary packaging
    4 effervescent tablets in strips made of three-layer material: paper/polyethylene/aluminum.
    Secondary packaging
    15 strips along with instructions for use in a cardboard box.

    Storage conditions

    In a dry place at a temperature not exceeding 25°C.
    Keep out of the reach of children.

    Best before date

    3 years.
    Do not use after expiration date.

    Vacation conditions

    Over the counter.

    Manufacturer

    Holder of RU: Sandoz d.d., Verovshkova 57, 1000 Ljubljana, Slovenia;

    Produced:
    1. Hermes Pharma Ges.m.b.H., Austria;
    2. Hermes Arzneimittel GmbH, Germany.

    Consumer complaints should be sent to Sandoz CJSC:
    123317, Moscow, Presnenskaya embankment, 8, building 1.