The antibiotic Gentamicin is intended for the treatment of infectious diseases caused by bacteria sensitive to its active component. Active substance has the same name as the drug, effectively affects pathogens. In pharmacies you can find medicine produced in Russia, Poland, and Belarus. Read the overview of the instructions for use of the medicine.

Composition and release form

Gentamicin is available in several formats for systemic and local exposure; it is not available in tablets. Composition and description of the products:

	Eye drops	Injection		Aerosol	Powder for making solution
Description	Transparent colorless or yellowish liquid	Clear liquid	White-yellow homogeneous ointment	White foam	White lyophilisate
Gentamicin concentration, mg					80 per bottle
Additional composition	Water, benzalkonium chloride, sodium chloride, sodium hydrogen phosphate, sodium dihydrogen phosphate	Water, sodium metabisulfite, disodium ethylenediaminetetraacetic acid, potassium dodecahydrate	Hard, liquid and soft paraffins, lactose monohydrate	Water, repellents
Package	5 ml dropper bottles	Ampoules of 1 or 2 ml, 10 pcs. in a pack with instructions	Aluminum tube 25 g	Aerosol bottle 140 g	Bottles of 10 ml, 5 bottles per pack

pharmachologic effect

The active component gentamicin is an antibiotic with a broad spectrum of action from the group of aminoglycosides. Once in the body, it binds to ribosomes, disrupts protein synthesis and stops the production of RNA of microorganisms; accumulation does not occur. The pathogen's RNA is read incorrectly and inactive proteins are formed. At high concentrations, the substance has a bactericidal effect, reduces protective function cytoplasmic membranes, leads to the death of bacteria.

Gram-negative bacteria and a number of gram-positive microorganisms are sensitive to the antibiotic. Neisseria meningitidis, Providencia rettgeri, Clostridium spp. are resistant to the drug. Treponema pallidum, Bacteroide spp., Streptococcus spp.. In combination with penicillins, the drug shows activity against enterococcus (Enterococcus) and streptococci of other species. The medication has no effect on fungi, viruses and protozoan microorganisms.

Pharmacodynamics and pharmacokinetics

The medication shows activity against aerobic gram-positive cocci and streptococcal strains. After parenteral administration Gentamicin sulfate is well absorbed, reaches maximum concentration after 30–60 minutes, and combines with albumin up to 10%. The substance is found in intracellular and cerebrospinal fluid, tissues, placenta. The component is not metabolized in the body and is excreted in urine (from 70%) and bile. The half-life is 2–4 hours. When used topically, pharmacokinetics have not been studied.

Indications for use of Gentamicin

The drug can be used to treat infectious and inflammatory diseases. Instructions for use highlight the following readings:

• acute cholecystitis, cholangitis;
• pneumonia, pleural empyema;
• cystitis, pyelonephritis;
• peritonitis, sepsis, ventriculitis;
• purulent infections of soft tissues, skin, wound, burn infections;
• infection of bones and joints;
• pyoderma, gangrenous skin lesions;
• superficial folliculitis, furunculosis, sycosis;
• infected seborrheic dermatitis;
• acne, insect bites, infected wounds, varicose ulcers;
• blepharitis, meibomitis, blepharoconjunctivitis;
• conjunctivitis, keratoconjunctivitis, dacryocystitis, keratitis.

Directions for use and dosage

Gentamicin in gynecology can be used to treat inflammatory diseases caused by infections. For this purpose, an injection solution is used. The dosage and course of treatment with drugs depend on the form of release of the drug, the type of disease and the severity of its course. According to the instructions, if the kidneys fail, the dose needs to be adjusted. The maximum daily dose of gentamicin is 5 mg/kg body weight.

Injections

According to the instructions, Gentamicin in ampoules is used for intravenous or intramuscular administration. If it is a powder, it is diluted with water for injection. A single dose for adults is 1–1.7 mg/kg of body weight, a daily dose is 3–5 mg/kg in 2–4 doses per day. The course of treatment lasts 7–10 days. It is possible to administer 120–160 mg once a day in a weekly course or 240–280 mg once. Intravenous infusions last 1-2 hours.

For children over two years of age, the daily dose of the drug is 3–5 mg/kg body weight three times a day. Prematures and newborns are prescribed 2–5 mg/kg body weight per day twice a day, children under two years of age are prescribed a similar dose, but three times a day. Before prescribing injections, the doctor must determine whether the microflora is sensitive to the active substance of the drug.

Ointment

Gentamicin ointment is intended for local external use. Before application, according to the instructions, you need to cleanse the skin of pus and necrotic masses. For large lesions, the daily dosage of the ointment cannot exceed 200 g. The product is applied to the skin 3-4 times a day, lightly rubbed in. The course of application of the ointment is determined by the doctor based on signs of improvement in the course of the disease.

Eye drops

Gentamicin drops are used to eliminate bacterial eye infections. According to the instructions, they are used topically - 1-2 drops are instilled into the lower conjunctival sac of the eyelid every 1-4 hours. The duration of use of the drug should not exceed 14 days, unless otherwise prescribed by the doctor. If there is no effect, the sensitivity of the microflora to the product should be determined again. For keratitis and conjunctivitis, drops are instilled three times a day.

Aerosol

Gentamicin aerosol is indicated for external use. According to the instructions, before applying to the skin, shake the bottle slightly, direct the dispenser to the treatment site and spray the product from a distance of 10 cm. The procedure can be repeated 3-4 times a day, after use the sprayer is cleaned. The bottle should be protected from shock and stored away from heating devices. The use of foam is contraindicated for application to the eyes.

special instructions

In the instructions for use of each form of Gentamicin there is a paragraph special instructions. Excerpts:

1. The drug is prescribed with caution for parkinsonism, myasthenia gravis, and renal dysfunction. During therapy, control of diuresis, vestibular, and hearing aids is indicated.
2. In patients with renal failure, the risk of the resorptive effect of the ointment increases when used for a long time on large areas of the skin.
3. The tip of a dropper bottle eye drops Do not touch any surface. The drug is instilled into the eyes from which the lenses have been removed. You can put the lenses back on after 30 minutes. When using the product, the clarity of vision may briefly decrease, so it is better to avoid operating machinery during therapy.
4. The solution contains sodium bisulfite, which may cause allergic reactions.
5. If the patient is taking medication for therapy urinary tract, he is advised to drink plenty of fluids.
6. During treatment with Gentamicin, the development of microflora resistance (resistance) is possible.

Gentamicin during pregnancy

The use of medication during pregnancy is prohibited in any form. Aminoglycosides cross the placenta and may cause adverse consequences in the fetus. Active substances are also found in breast milk, therefore, during therapy it is necessary to stop/interrupt breastfeeding. According to the instructions, no nutritional complications were recorded in infants whose mothers were treated with Gentamicin during lactation and were breastfed.

Gentamicin for children

Use the medicine for children early age It is possible only for health reasons. The use of the solution is indicated for infants. The instructions for the solution indicate its dosage: 2-5 mg/kg body weight per day in 2-3 doses. During treatment with the drug, the doctor must monitor the child’s condition. It is forbidden to increase the dosage on your own.

Drug interactions

If antibiotics are used simultaneously with other medicines, it is important to study their interaction. This is stated in the instructions:

1. The combination of the drug with vancomycin, ethacrynic acid, aminoglycosides, Kanamycin, Neomycin and cephalosporins leads to increased ototoxicity and nephrotoxicity.
2. The combination of the drug with indomethacin, loop diuretics (Furosemide) leads to a decrease in clearance of the former, an increase in concentration, and an increased risk of toxicity.
3. Simultaneous use of the drug with opioid analgesics or inhalation anesthesia can lead to neuromuscular blockade and apnea.

Side effects

The use of the medication may be accompanied by side effects. The most common, according to the instructions, are:

• digestive problems: hyperbilirubinemia, nausea, increased activity of liver enzymes, vomiting;
• hematopoietic disorders: thrombocytopenia, anemia, granulocytopenia, leukopenia;
• bronchospasm, cough with sputum;
• metabolic disorders, lymphatic flow;
• renal failure, oliguria, microhematuria, proteinuria;
• deafness, headache, coordination disorders, drowsiness, hearing loss, impaired conduction of nerves and muscles;
• allergies, angioedema, itching, fever, urticaria, angioedema, rash;
• eosinophilia;
• psychoses;
• paresthesia (loss of sensation);
• tissue necrosis, paronychia;
• hypokalemia, hypocalcemia, hypomagnesemia;
• development of superinfection;
• lacrimation, blurred vision, redness of the mucous membrane of the eyes, photophobia, burning sensation;
• pain at the injection site.

Overdose

With prolonged use of drops, it may develop fungal infection. Exceeding the dose of Gentamicin can lead to disruption of neuromuscular conduction and respiratory arrest. In case of overdose, Proserin, calcium preparations (for children) and anticholinest are administered different means. Before administering Prozerin, according to the instructions, you need to administer 0.6 mg of atropine intravenously and wait for the heart rate to increase. If there is no effect, Proserin is re-administered. An injection of Atropine will help with bradycardia. In case of overdose, peritoneal dialysis and hemodialysis are effective.

Contraindications

The medication is prescribed with caution to children. There are groups of patients who are prohibited from using the drug. Instructions for use highlight contraindications:

• hypersensitivity to the components of the composition, antibiotics from the aminoglycoside group;
• acoustic neuritis;
• uremia;
• pregnancy, breastfeeding;
• severe violations liver and kidney functions.

Terms of sale and storage

The medicine is sold by prescription and stored at 25 degrees for four years.

Analogues

The drug can be replaced by drugs based on the same active substance or from the group of aminoglycosides. Drug analogues include:

• Garamycin - injection solution, cream and ointment with the same active ingredient;
• Gentamicin Akos, Gentamicin-Teva, Gentamicin K are the same drug, but produced by different pharmaceutical companies;
• The agent is a direct substitute for the agent;
• Septopa is a close analogue of the drug with the same composition;
• Gentacyclol - plates made of collagen sponge based on gentamicin.

Aerosol, 140 g

"Gentamicin" (injections) today is considered a fairly strong medicine, belonging to a number of antibiotics - aminoglycosides. This drug is used in the most severe cases of infectious diseases, especially in the presence of unknown pathogens that are resistant to other medications.

"Gentamicin": release form, composition and properties of the drug.

This product is available in the form of liquid for injection. The active ingredient of the drug is gentamicin sulfate. In addition, sulfuric acid, disodium salt, sodium hydroxide and purified water for injection are used in the manufacture.

After administration, the medicine is absorbed quite quickly by the body, and its maximum concentration is recorded within an hour after administration. "Gentamicin" affects even those strains of bacteria that are insensitive to penicillin and metapenicillin antibiotics. The substance is usually excreted unchanged through the renal filtration system.

Antibiotic "Gentamicin" and indications for its use.

It was mentioned above that Gentamicin is very strong medicine, which is used in modern medicine for treatment especially serious illnesses. It is especially often prescribed when it is impossible to determine the nature of the pathogen. It is also effective among patients with impaired body resistance, which happens with diabetes, leukemia, etc.

The drug is used to treat infectious diseases of the skin, bone tissue, as well as in case of infection of burnt tissue. It works well when bacterial diseases respiratory and urinary tract, occurring in severe form. "Gentamicin" is used for infection abdominal cavity. In combination with other drugs, this medicine can be used to combat diseases of the central nervous system, including meningitis.

"Gentamicin" (injections): instructions for use.

This drug can be administered either intravenously or intramuscularly. Dosage, frequency of injections and duration of administration are determined only by the doctor, based on the severity of the disease, the patient’s age and associated violations.

The recommended dose for adults is 3 - 5 mg of Gentamicin per kilogram of the patient's body weight. Total The drug must be divided into 3-4 doses. At intravenous administration a solvent must be used. The duration of the course should be from seven to ten days. Taking the medicine for more than 10 days is allowed only in particularly severe cases, since this is when the toxic properties of the antibiotic begin to appear. In this case, the patient must be under constant supervision, as it is necessary to monitor the condition of the urinary tract, auditory analyzer And vestibular apparatus.

"Gentamicin" (injections): contraindications and side effects.

This drug should not be prescribed to patients with hypersensitivity or to an antibiotic, or to some other component.

In some cases, "Gentamicin" (injections) can be quite toxic to the human body. Sometimes performance problems occur as a side effect. excretory system. The drug may also affect some couples cranial nerves, including those that innervate the vestibular apparatus.

Symptoms such as nausea, vomiting, diarrhea and headache are much less common. In some cases, a rash, itching or hives may appear. Occasionally, cases of loss of appetite, weight loss, drowsiness, joint pain, and laryngeal swelling have been reported.

It can be noted that, despite all its effectiveness, the drug is not always well received human body. Therefore, under no circumstances should you change the dosage prescribed by your doctor or use the medicine without permission. If there are adverse reactions, it is recommended to continue treatment in a hospital setting.

Gentamicin is not produced in tablets. This antibiotic can be purchased in other forms. Self-medication can be dangerous to health and harm the body.

International generic name means - Gentamicin.

ATX

Gentamicin code is J01GB03.

Compound

The active ingredient is gentamicin sulfate. In addition to it, the composition of the solution for intravenous and intramuscular injections includes water, sodium metabisulfite, disodium salt, ethylenediaminetetraacetic acid. The composition of eye drops is different: in this dosage form excipients are water, sodium chloride, sodium dihydrogen phosphate monohydrate, benzalkonium chloride solution.

pharmachologic effect

Is antibacterial agent from the group of aminoglycosides. Shows wide range actions. Binds to bacterial ribosomes, disrupting the protein synthesis process of microorganisms. Helps against aerobic gram-negative bacteria and some types of aerobic gram-positive: strains of Streptococcus, Staphulococcus.

Has no effect on viruses, fungi, protozoa.

Pharmacokinetics

At intramuscular injection quickly absorbed, most high concentration in the blood is observed 30-90 minutes after the injection. Not metabolized. It is eliminated from the body of an adult in 2-4 hours.

What are Gentamicin tablets used for?

The medicine is prescribed for inflammatory processes that were caused pathogenic bacteria. Used for inflammatory diseases urinary tract, pyelonephritis, cholecystitis, peritonitis, sepsis, cholangitis, pneumonia, burn infections, wounds.

For external use it is prescribed for infected acne and varicose ulcers, paronchia, furunculosis, seborrheic dermatitis, superficial folliculitis.

Local application can be prescribed for conjunctivitis, keratitis, blepharitis, meibomitis.

Contraindications

Use is prohibited during pregnancy and lactation, for people with severely impaired renal function, hypersensitivity to the components of the drug, for uremia and neuritis of the auditory nerve.

Carefully

Since the drug has high ototoxicity, nephrotoxicity, it is prescribed only in the absence of other effective methods treatment. In addition, it is recommended to monitor renal function during treatment.

Relative contraindications are parkinsonism, botulism, myasthenia. Use with caution when treating infants, premature children, and the elderly.

Dosage and method of use of Gentamicin tablets

Doses vary depending on the pathology, its severity, and location. It is recommended to read the instructions for use and consult a doctor: a change in dosage regimen may be required.

When injected, 1.7 mg per 1 kg of body weight is administered. The medicine is administered 2-4 times a day. The therapeutic course ranges from a week to 10 days. A single use in a dosage of 240-280 mg 1 time is possible for some pathologies.

For children, dosages differ and depend on age. It is recommended to consult a pediatrician.

The ointment is applied externally 3-4 times a day, treating the damaged area. More than 200 g per day should not come into contact with the skin.

Eye drops are used every 1-4 hours.

Is it possible to take the drug for diabetes mellitus?

At diabetes mellitus take with caution. Therapy is carried out under the supervision of a doctor.

Side effects of Gentamicin tablets

Nausea, vomiting, increased levels of bilirubin, and increased activity of liver transaminases are possible. Leukopenia, anemia, and thrombocytopenia are sometimes observed. Headache and disturbances may occur neuromuscular transmission, paresthesia. IN childhood psychosis may appear. Some patients report proteinuria, microhematuria, oliguria, and renal dysfunction. Renal necrosis is rarely observed. Possible tinnitus, hearing impairment, allergic reactions.

Impact on the ability to operate machinery

You should be careful or refrain from driving a car or driving other vehicles.

special instructions

Some patients require dosage adjustments.

Use in old age

You need to be careful. Can be used in other dosages.

Prescription for children

Not prescribed within 10 days after birth. Doses differ from adults; consultation with a pediatrician is necessary.

Use during pregnancy and lactation

Not prescribed for expectant mothers or breastfeeding women.

Overdose

Neuromuscular conduction is impaired. Possible respiratory arrest.

It is necessary to administer intravenous Atropine. When the heartbeat becomes more frequent, Prozerin is administered.

Interaction with other drugs

If used simultaneously with Vancomycin, aminoglycosides, cephalosporins, toxicity increases. When used simultaneously with diuretics, Indomethacin the concentration of the drug in the blood becomes higher, which makes it more toxic.

Analogues

Colbiocin ointment containing 10 mg of chloramphenicol, 5 mg of roletetracycline and 180,000 IU of sodium colistimethate is effective. Tobrex solution helps a lot. Apply eye drops Maxitirol. Powder is used to prepare a solution for injection Mercatsin, containing amikacin 50 or 100 mcg per 1 ml.

Conditions for dispensing from a pharmacy

Sold only if prescribed by a doctor.

Can I buy it without a prescription?

Sale without a prescription is prohibited.

Price

Cost: approximately 40-50 rubles for 10 ampoules, 60 for ointment and 130 for a package of drops.

Storage conditions of the drug

Keep in a dry place where direct contact cannot penetrate. Sun rays, away from children. Observe temperature regime up to 25°C.

Gentamicin is antibacterial drug, in injections, which is used in the treatment of various infectious diseases. But for the drug to have therapeutic effect, before use, it is necessary to study in detail the instructions, reviews of doctors and patients about the effectiveness of the medicine.

pharmachologic effect

Gentamicin is an antibiotic, a pharmaceutical group of aminoglycosides. Antibacterial actions substances are based on blocking protein synthesis in bacterial cells and their deaths. Considering the actions of the active substance, this antibiotic used in injections for infections of various origins. In the pharmacy this antibiotic has various shapes: injection solution (injections), ampoules of 2 ml, liniment for external use, eye drops (Dexa-gentamicin drops).

When to use

According to the instructions, gentamicin sulfate 4% indications for use may have the following:

• Urinary system infections.
• Infectious diseases of the external skin, as well as burns and soft tissue infections.
• Septicemia.
• Prostatitis.
• Infections of the ENT organs and upper respiratory tract.
• Abdominal infections.
• Infections that occur against the background of reduced immunity.

• Pregnancy and lactation.
• Children under 3 years of age.
• Chronic renal or liver failure.

Injections: where to inject and how much

The dosage of Gentamicin in injections and the duration of the course of use are determined by the attending physician. Prescribed intravenous or intramuscular injections Getnamycin sulfate 4% solution, sold in ampoules of 2 ml, No. 10. The dose of antibiotics is determined based on the patient’s weight. The standard ratio is 3 mg of the drug per 1 kg of patient weight. 1 ml of solution for injections (injections) contains 40 mg of active substance, daily dose for a patient weighing 50 kg will be 150 mg = 4 ml (2 ampoules of 2 ml) 4% solution. It is recommended to inject 80 mg 2-3 times a day.

The dosage of the drug is determined by the doctor.

Therapy of urological diseases

The antibiotic is used in urology, especially in the treatment of prostatitis and cystitis. The dosage of medication for prostatitis or bacterial cystitis is determined according to a standard scheme, taking into account the patient’s weight category. On average, it is 80 mg 2-3 times a day every 6-12 hours. Complex forms of the disease may require the use of higher dose of the drug - up to 80 mg per kilogram of weight, but before starting treatment it is necessary to study the prescription and recommendations of the doctor. When injecting Gentamicin 4% solution, it is forbidden to mix several drugs in one syringe. For prostatitis and cystitis, the course of antibiotic use lasts 7-10 days.

When treating prostatitis, it is necessary to do simple tests to determine the sensitivity of the flora to the drug. After a course of intramuscular antibiotic injections, a man should remember that only after 4-6 months can he conceive a child. For cystitis and prostatitis, during treatment it is necessary to completely stop drinking alcohol to prevent nephrotoxicity.

The instructions for use recommend storing the drug at a temperature not exceeding 25 C. The instructions for use say that the shelf life is 3 years from the date of issue. To ensure that the instructions for use from the manufacturer are not lost during this time, it is best to keep the drug in its original packaging, away from children. The ointment and drops retain their quality for 3 years from the date of issue. To buy medicine at a pharmacy, you just need to take a prescription with the recommended dose of the antibiotic and the duration of the course of treatment.

Special cases

When treating children, gentamicin sulfate is prescribed if there are vital indications, when the benefit to the baby outweighs the risk of side effects. For the treatment of infections in children under one year of age daily dosage is calculated based on the proportion of 1 mg per 1 kg of weight, for children aged 3 to 5 years - the dose becomes 1.5 mg per 1 kg, for children over 6 years old - 3 mg per 1 kg of weight. Children are injected with the medicine intramuscularly 2 times every 12 hours.

The drug can be used by children.

With an intestinal infection in very in rare cases Gentamicin is prescribed to children. Indications for use are the sensitivity of the pathogen only to this antibiotic. In the first 2-3 days, the use of gentamicin for intestinal pathology carried out intravenously, after which injections are given intramuscularly into the buttock (80 mg 2-3 times a day after 6-12 hours).

For prolonged rhinitis, the doctor may recommend for children and adults complex drops into the nose. To prepare them, you must provide the pharmacy with a prescription from a doctor. Gentamicin sulfate 4% is often included in the recipe for complex nasal drops as a bactericidal component. Complex drops are called that because the actions of their components simultaneously have several directions: antiallergic, bactericidal, vasoconstrictor, decongestant. You should not prepare complex drops on your own, even if you have a recipe; they contain several components that, if mixed incorrectly, can have adverse side effects. The doctor will write a prescription and the necessary ingredients for each patient individually, taking into account the severity and type of disease.

During pregnancy, the use of the product internally and externally is prohibited, even if there are indications. The medicine negatively affects the auditory and vestibular system of the fetus because it penetrates the placenta. Even complex drops are not recommended for use during pregnancy to treat rhinitis.

Prescription for other infections

In ophthalmology, antibacterial eye drops Dexa Gentamicin are used, 5 ml in a bottle, the original packaging is green, as in the photo. This form The antibiotic has proven itself effectively in the treatment of purulent conjunctivitis, blepharitis, dacryocystitis, and keratitis. The product is dripped into the lacrimal sac, 1-2 drops at a time, while moving the lower eyelid. You can also buy eye ointment 2.5 g, which is placed behind the lower eyelid and distributed evenly throughout the eye.

The product is used in ophthalmology.

Purulent or bacterial infection of the ENT organs ( purulent otitis media) are also treated with this antibiotic, release form - ear drops and solution for injection. For an infection of the throat or nasopharynx, doctors prescribe gentamicin sulfate 4% solution for inhalation into the nose and throat, using it as a local antibacterial drug. This method of treatment is especially relevant when prescribed to children who do not like to receive injections. A nebulizer will help to spray the product. The solution is poured into the nebulizer body, inhaling into the nose and throat 2-3 times a day after 3-4 hours. For convenient use, the nebulizer comes complete with a nozzle for the nose, throat and mask.

Gentamicin is part of the combined liniment for the treatment dermatological diseases. Indications for use: eczema, allergic dermatitis, bacterial infections, neurodermatitis. This ointment contains betamethasone, clotrimazole, it is sold ready-made and does not require a prescription to make it. It is not recommended to use this liniment during pregnancy. The oral form of gentamicin tablets is of interest to all patients. The medicine is not available in tablet form; you can buy another drug of the same group of antibiotics in tablets.

Possible complications

At long-term use, and also when individual intolerance medicine or its components may cause side effects. If the patient has side effects medications, you need to tell your doctor about them. It can be:

• Nausea, vomiting, diarrhea.
• Proteinuria, azotemia, oliguria.
• Violation of the vestibular apparatus, sharp deterioration hearing
• Intramuscular injections can be complicated by redness and pain.

What can be replaced

Gentamicin is produced by various pharmaceutical concerns, dosage form may vary. Below is approximate price for the drug and its analogues in Russian pharmacies.

Name of the drug and manufacturer	Packaging and concentration
GENTAMICIN-FEREIN Bryntsalov	4% solution, ampoules of 2.0, No. 10 per package
GENTAMICIN-FEREIN Meda	Eye drops, 5.0 per bottle
GENTAMICIN AKOS Synthesis of AKOMP	Eye drops, 5.0 ml
GENTAMICIN AKOS Meda	Eye ointment, 2.5 mg
Gentamicin sulfate Belarus	4% solution for injection, 2.0 in ampoule	30 rub. per package No. 10
Gentamicin ointment, Russia	0.1% ointment, 15 g	22 rub. price per tube
Dexa-Gentamicin drops Germany	Eye drops 5.0 ml	average price 92 rub.

Modern pharmacy can offer analog drugs that are not inferior in effectiveness (Amgent, Gencin, Garamycin, Gentamicin-Teva, Gentamicin-Akos, Septopa). Patients often look for this drug or analogs in tablet form, but, as mentioned above, all gentamicin analogs are available only in the form of powders, solutions, drops and liniment. If there is an urgent need, you can choose another antibiotic in tablets, for example Neomycin, 250 mg tablets and 500 mg tablets. The tablet form is convenient to use, but the effectiveness is less pronounced. Despite many years of experience and positive reviews patients and doctors about the use of gentamicin sulfate, the drug and its analogues should be used only after consultation with the attending physician, strictly following the instructions for use and medical recommendations.

Gentamicin injections are an antibacterial agent that is used in the treatment of various infectious diseases. But in order for the drug to become effective and therapeutically effective, it is necessary to carefully read the package insert before use and study the reviews of patients and the treating doctor.

Pharmacological effect

Gentamicin injections are a topical antibiotic pharmaceutical group aminoglycosides. The antibacterial actions of the components are based on the block of protein synthesis in bacterial cells and their destruction. Considering the efficiency active ingredients, the medicine is used for intramuscular injections. On pharmacy shelves it is presented in various forms: injection solution with ampoules of 2 ml, liniment for external use, eye drops.

When is it rational to use gentamicin injections?

According to the description in the package insert, the active substance of the medicine is recommended for use for:

• Infections of the genitourinary system.
• External infections skin, as well as burns and soft tissue infections.
• Blood poisoning.
• Inflammation prostate gland.
• Laryngeal infections and upper section respiratory system.
• Abdominal infections.
• Infections that manifest themselves against the background of uncoordinated functioning of the immune system.

You should not prescribe the medicine in any of the presented dosage forms:

1. While expecting a baby or breastfeeding.
2. Children under three years of age.
3. For chronic kidney or liver diseases.

Gentamicin intramuscularly: where and how much to administer

The dosage of gentamicin in injections and the course of use are determined by the treating specialist. Injections are prescribed intravenously or intramuscularly. For this purpose it is used special solution what is sold in ampoules different dosages. The dose of the active substance is determined based on the patient’s weight. The classic ratio is 3:1 kg to a person’s weight.

A milliliter of injection solution contains forty milligrams active substances, the 24-hour dose for a patient weighing fifty kg would be one hundred and fifty mg = four milliliters. It is recommended to administer 80 mg up to three times a day.

Therapy of urological ailments

How to inject gentamicin to a person suffering from urological diseases, especially with prostatitis and cystitis? The dosage of the drug is determined according to classic scheme, taking into account the patient’s weight. On average, it reaches 80 mg twice in 24 hours, after twelve hours.

Chronic forms may require use maximum dose drugs - up to 80 mg per kg of weight, but before starting to take the drug, you must read the package insert and the specialist’s prescription. When administering the drug intravenously or intramuscularly, it is prohibited to combine different drugs in one syringe. For inflammation of the prostate gland and inflammation Bladder the course of application lasts a week.

When treating inflammation of the prostate gland, it is necessary to conduct a series of simple laboratory tests to determine the sensitivity of the flora to the active substances of Gentamicin. After a course of intramuscular antibiotic therapy, a man must additionally note that he can conceive a child after six months. In case of inflammation of the bladder and prostate gland, during treatment it is necessary to completely exclude alcoholic drinks to prevent the onset of nephrotoxic shock.

Special cases

When treating children, gentamicin is prescribed when vital signs when the benefit to them outweighs the possibility of causing side effects. For injections in one-year-old children, the daily dose is calculated based on the proportion of milligrams per kilogram of weight, for children from three to five years old - the dose becomes one and a half mg per kilogram of weight, for children over six years old - three milligrams per kilogram of weight. Children are prescribed intramuscular injections twice a day every 12 hours.

At intestinal infections In exceptional cases, the drug is prescribed to infants. Indications for use: sensitivity of the provocateur to the active substances of Gentamicin. In the first 48 hours intestinal diseases, the medication is administered intravenously, after which the drug is administered intramuscularly at 80 mg every 12 hours for several days.

For prolonged inflammation of the nasal mucosa, the doctor recommends that children and adults use nasal drops. They are prepared by pharmacists after providing a prescription from the attending physician. The active substances of the drug in question are often included in the recipe according to which special drops for rhinitis are prepared, as a bactericidal component.

Incorrect mixing of different components can cause a number of adverse side effects. The doctor will write out a prescription and the amount of ingredients for each individual case, taking into account the severity and type of illness. While waiting for the baby, it is prohibited to use the drug in any accessible form, even if there are all clinical indications for this.

Active substances have a detrimental effect on the functioning of the auditory and vestibular apparatus of the embryo, because they are able to overcome the placental barrier. Even complex drops should not be used to treat inflammation of the nasal mucosa while expecting a baby

Special Cautions

Before starting treatment with the drug described in the article, be sure to pay attention to the special instructions regarding its use, which include impaired renal function or the appearance of tinnitus - requires immediate cessation of use of the drug.

In exceptional cases, the injection solution is prescribed to young children. If the drug is indicated for a woman who is breastfeeding, the baby should be switched to formula or replaced at this time mother's milk- cow.

• During the course of administration of the injection solution, periodic laboratory test main biochemical functions renal activity and liver functionality.
• Under constant medical supervision, the drug is prescribed to people with possible dehydration (dehydration) and myasthenia gravis (weakness of the muscle core).
• The medicine can be supplemented with drugs of another pharmacological class, in particular if it is combined with a loop diuretic (diuretic drug). In the latter case it negative impact may enhance kidney function.
• The drug does not affect concentration and speed of psychomotor reaction.
• In the city network of pharmacies, the injection solution is sold according to a doctor's prescription. You should not use it yourself or do it on the recommendation of third parties.

Injection analogues

The drug in question is the only one that contains an antibiotic of the aminoglycoside class, gentamicin, as an active substance. There are a number of dosage forms of this drug - tablets, ointments.

A number of complications

With a long course of treatment, as well as with personal intolerance to the drug or its active substances, the medicine can cause a number of side effects. If the patient has negative reactions to the drug, you need to report them to a specialist. They may be:

• A feeling preceding vomiting or vomiting itself, indigestion.
• Excretion of protein in urine; increased content in the blood of nitrogenous products; decrease in the amount of urine excreted by the kidneys.
• Loss of coordination of movements, sudden loss of hearing.
• Intramuscular injections can cause various redness and pain.

Are there any analogues

The drug discussed in the article is produced by various pharmaceutical companies, the dosage form is different.

When it is prohibited to use the drug and conditions of use

The active substances gentamicin, like other types of aminoglycosides, have side effects. The antibiotic has toxic efficacy on various organs and life systems:

• Ototoxic effect.
• Damages auditory nerve, which can cause the development of sensorineural hearing loss.
• Disorders of the vestibular apparatus.
• Decreased neuromuscular core activity
• Nephrotoxic effect.
• The outflow of urine decreases, which provokes toxic releases into the bloodstream
• Development of microhematuria and proteinuria
• The effect of the drug can also have a detrimental effect on the functioning of the intestines and liver.
• Possible disruption of blood flow functions as one of the side effects. Reception pharmacological agent may provoke allergic reactions.

The active substances of gentamicin can cause a significant decrease or complete irreversible deafness.

Gentamicin is contraindicated while expecting a baby, as well as during its breastfeeding. Extra Caution should be observed in patients with problems hearing aid, kidney function, idiopathic parkinsonism syndrome, autoimmune diseases muscular core.

The bactericidal agent is used to treat many diseases and has high antibacterial activity. Due to its high toxicity, it is necessary to take Gentamicin only when other means cannot help, and the benefit to the patient is much higher than the potential risks.

Combination with other drugs

Row pharmacological drugs can double the ototoxic and nephrotoxic effect:

• aminoglycosides, vancomycin;
• cephalosporins and ethacrynic acid;

Mutual enhancement of effectiveness may also occur when joint reception Gentamicin with carbenicillin and antibiotic penicillin group, cephalosporins.

Clinical studies have shown that taking loop diuretics, indomethacin and Gentamicin increases the possibility adverse reaction. Medications class of muscle relaxants can provoke asphyxia. Due to the formation of dangerous complex combinations, it is not recommended to administer the drug described in the article simultaneously with other drugs in the same syringe.