(part of Eufillin )

B Aminophylline (text from instructions)⇒ Prednisolone (he was found)

Basic interactions (Aminophylline)

Increases the likelihood of developing side effects of glucocorticoids, mineralocorticoids (hypernatremia), anesthetics (increases the risk of ventricular arrhythmias), xanthines and drugs that excite the central nervous system (increases neurotoxicity), beta-adrenergic agonists. Reduces the specific activity of lithium salts. Oral contraceptives (estrogen-containing), antidiarrheal drugs, intestinal sorbents weaken, and H2-histamine blockers, fluoroquinolones, CCBs, beta-blockers, mexiletine, erythromycin enhance the effect (bind to the cytochrome P450 enzymatic system and slow down the biotransformation of aminophylline).

Interactions from trade names (Eufillin)

do not mix with acid solutions. Increases the likelihood of developing side effects of GCS, MCS (hypernatremia), drugs for general anesthesia (increases the risk of ventricular arrhythmias), drugs that excite the central nervous system (increases neurotoxicity). Rifampicin, phenobarbital, phenytoin, isoniazid, carbamazepine, sulfinpyrazone, aminoglutethimide, oral estrogen-containing contraceptives and moracizine, being inducers of microsomal oxidation, increase the clearance of aminophylline, which may require an increase in its dose. With the simultaneous use of macrolide antibiotics, lincomicin, allopurinol, tsimetidine, isoprenaline, ennoxacin, small doses of ethanol, disulfiram, fluoroquinolones, recombinant alpha interferon, methotrexate, mecsiletin, propaphenone, thiabendazole, thyclopidine, verapamyl and under flu vaccination intensity of aminophylline increase, which may require a reduction in its dose. Enhances the effect of beta-agonists and diuretics (including by increasing glomerular filtration), reduces the effectiveness of Li+ drugs and beta-blockers.
Compatible with antispasmodics, do not use in combination with other drugs; xanthine derivatives. Prescribe with caution simultaneously with anticoagulants.

Decoding the colors of interactions and contraindications

You can click on these buttons to read more.

• Not found - Kiberis did not find interactions between drugs, which means they most likely do not interact.
• Unclear - the system was unable to pre-assess the danger.
• No - the drugs do NOT interact.
• Negative - a negative interaction or side effect that may reduce effectiveness.
• Dangerous! - a pronounced negative interaction or contraindication that can be dangerous.
• Positive - interaction SOMETIMES can be used as a positive (dosage adjustment is often needed), or it is an indication of the drug.

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Many of us have encountered illnesses where breathing was difficult, shortness of breath was excruciating, and it was impossible to clear our throat. Often, the doctor prescribed a remedy such as Eufillin, which brought instant relief. Asthmatics know about this drug firsthand: it is their constant companion, a savior during asthmatic attacks. Possessing powerful vasodilating and bronchodilating effects, the medicine quickly relieves unpleasant symptoms caused by bronchial obstruction, bronchospasm. It is most effective to use Eufillin intravenously.

Pharmacological action

The drug Eufillin is a bronchodilator, antispasmodic, vasodilator and bronchodilator. The active substance of the drug aminophylline has a relaxing effect. By expanding the bronchi, it helps to reduce the tone of their muscles and eliminate spasms. The drug has a beneficial effect on respiratory function, saturating the blood with oxygen and reducing the content of carbon dioxide in it. At the same time, the medicine relieves pressure on blood vessels, improving function cardiovascular system, in particular, the functioning of the myocardium.

Eufillin stimulates the renal blood supply, due to which the formation and outflow of urine from the body increases, that is, it has a mild diuretic effect.

Providing a tocolytic effect, the drug increases acidity gastric juice. By slowing platelet aggregation, the drug has a beneficial effect on red blood cells, making them more invulnerable to damage, as well as thinning the blood.

The drug, entering the digestive tract, quickly spreads through the bloodstream throughout the body. The onset of the effect slows down when consuming food simultaneously with Eufillin. Easily penetrates the placenta and is excreted in breast milk.

The medicine is processed in the liver and leaves the body in the urine.

Release forms and composition

The drug is released in tablet form with a dosage of 150 mg.

The most common injection solution is produced in ampoules. The content of the active substance in the solution can be 2.4 mg/ml or 240 mg/ml. The first option is used for intravenous administration, the second - for intramuscular administration. IN cardboard box there are 5 or 10 ampoules of 5 or 10 ml each.

Eufillin, injections, contains:

• aminophylline, active substance - 24 or 240 mg;
• water for injection - 1 ml.

Indications for use

The medicine is prescribed in the case of:

• bronchial asthma;
• asthmatic bronchitis;
• chronic obstructive pulmonary disease;
• emphysema;
• the presence of a “pulmonary” heart;
• Pickwick's syndrome (apnea);
• promotion intracranial pressure.

Parenteral solution for internal administration is used:

• to relieve asthmatic attacks;
• in case of acute disorder cerebral circulation(stroke) and cerebral edema;
• in the presence of left ventricular failure with bronchospasm of the Cheyne-Stokes type;
• in cases of apnea in newborns;
• if there is acute or chronic heart failure;
• to relieve intracranial pressure, as well as pressure in the pulmonary vessels;
• for edema caused by kidney pathologies;
• for neuralgia.

Contraindications

The drug, like any other drug of synthetic origin, has a number of contraindications. Eufillin is not used for:

• some heart diseases (myocardial infarction) and disorders heart rate(arrhythmias, extrasystoles, tachycardia);
• coronary insufficiency;
• epileptic disease;
• stomach ulcer and duodenum in the acute phase;
• exacerbation of gastritis;
• severe pathologies of the liver and kidneys;
• the presence of hemorrhage in the retina of the eye;
• allergies to aminophylline.

For the treatment of neuralgia and osteochondrosis, a dropper of Eufillin with Dexamethasone is used.

Children under 14 years of age, pregnant and lactating women, elderly people, patients with vascular atherosclerosis and prostatic hyperplasia are treated with caution.

Eufillin, instructions for use in ampoules

The drug is prescribed by a doctor for each patient individually. This takes into account the diagnosis, the patient’s age and weight.

If it is necessary to relieve bronchospasm, intravenous administration of the drug in large quantities is indicated. The medicine is administered through a dropper, the solution for which contains:

• 10-20 ml Euphyllin;
• 10-20 ml of 9% sodium chloride solution;
• 0.5 l of saline solution.

The drug is administered over 30 minutes. For 1 kg of patient weight, 5-6 mg of medication is needed. When introducing a drip, it is necessary to monitor the patient's blood pressure and heart rate.

In order to relieve an attack of bronchial asthma, it is necessary to administer 750 ml of medication using a dropper.

For intravenous administration, Eufillin is mixed with a solution of sodium chloride. The intravenous injection is given slowly, over 6 minutes. With simultaneous treatment with Euphylline and Theophylline, the dosage of the former is reduced by half.

An injection of Eufillin intramuscularly is quite painful. For injections, exclusively thick needles are used. Dosage: single dose - 7 mg/kg, daily dose - 13 mg/kg. The drug is used more than three times per day. The duration of treatment is 14 days.

The medicine is also used for inhalation, which is carried out for bronchospasms and asthmatic attacks in children. To prepare the solution you need:

• Euphyllin ampoule 2.4%;
• three ampoules of Diphenhydramine;
• 150 ml saline solution.

The dosage of the solution is prescribed by the pediatrician, depending on the diagnosis and body weight of the child. A nebulizer is used as an inhaler.

Side effects

The drug can cause numerous side effects. They appear:

• headaches and dizziness;
• excited state, insomnia, anxiety, tremor, flushing, fever;
• a sharp decrease in blood pressure, heart rhythm disturbances (tachycardia, arrhythmia, palpitations), exacerbation of angina pectoris;
• nausea, vomiting, heartburn, exacerbations of gastritis and ulcers, diarrhea and loss of appetite;
• allergic manifestations (itching, rash and other skin rashes, edema, etc.), increased sweating;
• increased shallow breathing and chest pain;
• a drop in blood sugar below normal;
• an increase in the daily volume of urine, the presence of blood in the urine, and the excretion of protein in the urine;
• convulsions;
• compaction and pain at the injection site.

Whenever side effects it is necessary to stop treatment and seek advice from your doctor.

Overdose

An overdose of Eufillin can manifest itself:

• intestinal or stomach bleeding;
• anxiety and sleep disorders;
• nausea and vomiting with blood discharge;
• tachycardia;
• decreased blood pressure;
• swelling of the face;
• ventricular arrhythmia;
• photophobia;
• convulsions.

If poisoned by the drug, a person may fall into a coma.

In case of drug overdose, you must immediately call an ambulance.

Eufillin during pregnancy

Often, pregnant women experience swelling, which sometimes cannot be eliminated using conventional methods, that is, using diuretics. In this case, Eufillin is prescribed, which, by dilating blood vessels, stimulates the kidneys, helping them remove excess fluid from the body.

Take the drug during pregnancy extremely carefully and only under the supervision of the attending physician, since in the first two trimesters the formation of internal organs unborn baby, and the medicine has the ability to penetrate the placental barrier. The product is used only when absolutely necessary. Start using it with small doses, gradually increasing the amount. Therapy with the drug is prescribed in short courses, no more than a few days. In rare cases, the dose is increased to 1 month.

Alcohol compatibility

Most medications are incompatible with alcohol consumption. Eufillin is one of these medications. Aminophylline can enhance the effect of many chemicals, in particular alcohol. When used simultaneously with alcohol, the drug may cause:

• a sharp decrease in blood pressure, up to collapse;
• symptoms of suffocation;
• disturbance of heart rhythms (arrhythmia, tachycardia, palpitations);
• relaxation of the lung muscles, which may impair respiratory function;
• bleeding in the brain if the blood vessels are weakened.

Rarely, simultaneous use of alcohol and Eufillin can be fatal.

Interaction with other drugs

The drug is incompatible with medications containing any acids. Combined use with certain types of antibiotics may enhance the effect of Eufillin, therefore, the dosage of the latter will need to be reduced. If you take the drug with Dexamethasone or Prednisolone, side effects may increase.

Medicines such as Carbamazepine, Diphenin, Sulfinpyrazone, Phenytoin, Phenobarbital, etc., reduce the effect of aminophylline, therefore, its dosage is increased when taken simultaneously with these drugs.

The simultaneous use of Eufillin with diuretics and beta-agonists enhances the effect of the latter. The drug reduces the effectiveness of beta-blockers and lithium preparations.

Features of the use of Eufillin

Intravenous administration of the drug is carried out subject to certain conditions:

• before use, the medicine must be heated to human body temperature;
• begin administration with a minimum dosage, gradually increasing it;
• the drug is not diluted with glucose solution;
• During administration, strict monitoring of the patient's blood pressure and pulse is necessary. If they change, it is necessary to reduce the rate of administration;
• upon introduction large doses, control the content of Euphyllin in the blood. If necessary, the dosage of the medication is reduced.

During drug therapy, you should refrain from carrying out work that requires maximum concentration of attention, as well as from driving vehicles.

Price for the drug in the pharmacy chain

The price may vary depending on the pharmacy chain and its location.

Eufillin's analogs

Analogs of the drug that have an identical effect:

• Aminophylline;
• Prednisolone;
• Tizol;
• Berodual et al.

Reviews

Patients speak of the drug Eufillin as an effective and proven remedy that really works. Many, especially those who have lung problems, have medicine in home medicine cabinet. It also perfectly relieves swelling during pregnancy. The reviews speak for themselves:

Anna, 28 years old.

“During pregnancy, my legs swelled a lot. Popular diuretics did not bring the desired effect. At the next appointment, the attending physician was simply horrified when he looked at my limbs and prescribed Eufillin injections. After several injections, the swelling went away, and my legs became the same. Just remember that the dosage of the medicine is prescribed by the doctor. It is necessary to be treated with the drug under his strict supervision.”

Irina, 40 years old.

“I recently got sick with bronchitis, after which I started having problems with my lungs. From time to time, I began to feel out of breath when simply bending over. During the next such attack, my sister called ambulance. The doctor administered the drug Eufillin intravenously. Unpleasant symptoms They went away instantly, and breathing returned to normal. Now I keep pills in my medicine cabinet at home, which I immediately take when an attack approaches. This product has become my lifeline.”

The drug Eufillin is an excellent remedy that saves human lives in unforeseen situations associated with asthmatic or cardiac suffocation. People suffering from breathing problems should always carry this medicine with them to avoid disastrous consequences.

Magnesium sulfate intramuscular instructions for beginners and professionals Ortofen: what are non-steroidal drug injections used for? Meloxicam: detailed instructions for the use of injections for the treatment of pathologies of various origins

Application: Vomiting during cytostatic chemotherapy.

• Granisetron (-)

Latin name: Kytril

Pharmacological groups: Antiemetics with ed. Serotonergic s ki s ed s tva

Nosological classification (ICD-10): R11 Nausea and vomiting. Z100 CLASS XXII Surgical practice. Z51.0 Chickens with radiotherapy. Z51.1 Chemotherapy for neoplasm

Pharmacologically with some dey with twie

Latin name: Euphyllin

Pharmacological groups: Adenosinergic drugs

Nosological classification (ICD-10): G46 Cerebral stroke syndromes in cerebrovascular diseases. G93.6 Cerebral edema. I27 Other forms of pulmonary-cardiac insufficiency. I50.1 Left ventricular failure. I99 Other and unspecified disorders with and with the topic of blood circulation. J42 Chronic bronchitis, unspecified. J43 Emphysema. J45 A with tma. J98.8.0 Broncho with spasm. N17 Kidney failure. R60 Edema, not classified in other sections

Application: Chronic obstructive bronchitis, bronchial asthma (drug of choice in patients with physical stress and as an additional remedy for other forms), and with tmatica with tattoo (additional therapy), pulmonary emphysema, apnea of ​​newborns (a condition characterized by periods of breathing for 15 seconds and accompanied by cyanosis and bradycardia), Cheyne-Stoke breathing.

Treatment: drug withdrawal, stimulation of its excretion from the body (gastric lavage, forced diuresis, hemosorption, plasma absorption, hemodialysis, peritoneal dialysis), with symptomatic therapy.

For apnea of ​​newborns, the initial dose is 5 mg/kg (administered via nasoga with a trawl tube), the maintenance dose is 2 mg/kg, in 2 divided doses. Chickens are left with treatment for several weeks, and in rare cases, eggs are lost.

Latin name: Euphyllinum pro injectionibus

• Euphyllinum for injection (Euphyllinum pro injectionibus)

Latin name: Euphyllin-Darnica

• Euphyllin-Darnica

Application: HIV-1 infections in adults and children (in combination with other antiretroviral drugs from the group of nucleoside analogues).

• Nelfinavir (-)

Latin name: Viracept®

Pharmacological groups: Medications for the treatment of HIV infections

Nosological classification (ICD-10): B20-B24 Disease caused by human immunodeficiency virus [HIV]

Application: Anesthesia: introductory, for short-term surgical, diagnostic and therapeutic procedures, with minimal accompanying painful sensations, during long-term surgical operations (in combination with narcotics, analgesics and inhalation anesthetics).

Treatment: intubation and mechanical ventilation, infusion of plasma substitutes, administration of vasopres with oral edema and cardiotonics; in case of development with drugs - intravenous diphenin, in case of ineffectiveness with ti - diazepam or general anesthesia and miorelak with anta.

• Methohexital (-)

Latin name: Pentaglobin

Pharmacological groups: Immunoglobulins

Nosological classification (ICD-10): A39 Meningococcal infection. A40 Streptococcal with epticaemia. A41 Other with pepticemia. A48.3 Current shock syndrome. A49 Bacterial infection of unspecified location. D80 Immunodeficiencies with predominantly body deficiency of antibodies. D84.9 Immunodeficiency, unspecified.

G00 Bacterial meningitis, not classified in other sections. G00.3 Staphylococcal meningitis. I33 Third and sub-third endocarditis. J15.1 Pneumonia caused by Pseudomonas (with aeruginosa). O85 By s Lerodova s ​​ep s and s. T86.0 Rejection of bone marrow graft. Z26.9 ​​Immunization against an unspecified infectious disease is required. Z29.1 Preventive immunotherapy

in ampoules of 10 or 20 ml and in bottles of 50 or 100 ml; in a cardboard pack there is 1 ampoule or 1 bottle.

Indications: Bacterial infections (in combination with antibiotics); immunodeficiency condition, secondary syndrome with insufficient antibodies.

It effectively weakens the strength of live virus vaccines (against measles, fever, mumps, chickenpox).

Recommended doses: newborns and infants 5 ml/kg/day for 3 days, older children and adults with severe bacterial infections- 5 ml/kg/day for 3 days, in case of immunodeficiency and secondary syndrome with insufficient antibodies - 3–5 ml/kg, treatment can be repeated in chickens after 1 week.

It is possible that false positive data may appear during serological and research studies.

• Pentaglobin

Application: Liquefaction and facilitation of sputum discharge in chronic and non-specific lung diseases, fibrosis of lung tissue.

Pharmacological action

The drug Eufillin is a bronchodilator, antispasmodic, vasodilator and bronchodilator. The active substance of the drug aminophylline has a relaxing effect. By expanding the bronchi, it helps to reduce the tone of their muscles and eliminate spasms. The drug has a beneficial effect on respiratory function, saturating the blood with oxygen and reducing the content of carbon dioxide in it.

Eufillin stimulates the renal blood supply, due to which the formation and outflow of urine from the body increases, that is, it has a mild diuretic effect.

Providing a tocolytic effect, the drug increases the acidity of gastric juice. By slowing platelet aggregation, the drug has a beneficial effect on red blood cells, making them more invulnerable to damage, as well as thinning the blood.

The drug, entering the digestive tract, quickly spreads through the bloodstream throughout the body. The onset of the effect slows down when consuming food simultaneously with Eufillin. Easily penetrates the placenta and is excreted in breast milk.

The medicine is processed in the liver and leaves the body in the urine.

The principle of action of the drug

Dexamethasone is a glucocorticosteroid drug produced synthetically as an analogue of cortisol produced by the adrenal cortex. For osteochondrosis, injections are used during an exacerbation period or Desamethasone in tablet form.

The drug affects the entire body as a whole, triggering a number of reactions, such as enhancing the transmission of adrenaline neurotransmitters, which can increase blood pressure, and also suppresses inflammatory reactions by blocking the release of prostaglandin by mast cells and eosinophils. Due to this, inflammation in the foci of acute osteochondrosis is reduced, blood circulation is normalized, relieving swelling in the soft tissues, as well as their intoxication.

Often, the use of glucocorticosteroid drugs is combined with compatibility-tolerant drugs, muscle relaxants, vasodilators, vitamins and analgesics to achieve maximum results from the procedure.

Release forms and composition

The drug is released in tablet form with a dosage of 150 mg.

The most common injection solution is produced in ampoules. The content of the active substance in the solution can be 2.4 mg/ml or 240 mg/ml. The first option is used for intravenous administration, the second - for intramuscular administration. A cardboard box contains 5 or 10 ampoules of 5 or 10 ml.

Eufillin, injections, contains:

• aminophylline, active substance - 24 or 240 mg;
• water for injection - 1 ml.

In this article you can read the instructions for use of the drug Dexamethasone.

Feedback from site visitors - consumers - is presented of this medicine, as well as the opinions of specialist doctors on the use of Dexamethasone in their practice. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation.

Dexamethasone is a synthetic glucocorticosteroid (GCS), a methylated derivative of fluoroprednisolone. It has anti-inflammatory, antiallergic, immunosuppressive effects, increases the sensitivity of beta-adrenergic receptors to endogenous catecholamines.

Interacts with specific cytoplasmic receptors (receptors for GCS are found in all tissues, especially in the liver) to form a complex that induces the formation of proteins (including enzymes that regulate vital processes in cells.)

Protein metabolism: reduces the amount of globulins in plasma, increases albumin synthesis in the liver and kidneys (with an increase in the albumin/globulin ratio), reduces synthesis and increases protein catabolism in muscle tissue.

Lipid metabolism: increases the synthesis of higher fatty acids and triglycerides, redistributes fat (fat accumulation occurs mainly in the area shoulder girdle, face, abdomen), leads to the development of hypercholesterolemia.

Carbohydrate metabolism: increases the absorption of carbohydrates from the gastrointestinal tract; increases the activity of glucose-6-phosphatase (increasing the flow of glucose from the liver into the blood); increases the activity of phosphoenolpyruvate carboxylase and the synthesis of aminotransferases (activation of gluconeogenesis); promotes the development of hyperglycemia.

Water-electrolyte metabolism: retains Na and water in the body, stimulates the excretion of K (mineralocorticoid activity), reduces the absorption of Ca from the gastrointestinal tract, reduces bone mineralization.

The anti-inflammatory effect is associated with inhibition of the release of inflammatory mediators by eosinophils and mast cells; inducing the formation of lipocortins and reducing the number of mast cells producing hyaluronic acid; with a decrease in capillary permeability; stabilization of cell membranes (especially lysosomal) and organelle membranes.

Valid at all stages inflammatory process: inhibits the synthesis of prostaglandins (Pg) at the level of arachidonic acid (lipocortin inhibits phospholipase A2, suppresses the liberation of arachidonic acid and inhibits the biosynthesis of endoperoxides, leukotrienes, which contribute to the processes of inflammation, allergies, etc.

The immunosuppressive effect is due to the involution caused lymphoid tissue, inhibition of the proliferation of lymphocytes (especially T-lymphocytes), suppression of the migration of B cells and the interaction of T and B lymphocytes, inhibition of the release of cytokines (interleukin-1, 2; interferon gamma) from lymphocytes and macrophages and a decrease in the formation of antibodies.

The antiallergic effect develops as a result of a decrease in the synthesis and secretion of allergy mediators, inhibition of the release of histamine and other biologically active substances from sensitized mast cells and basophils, a decrease in the number of circulating basophils, T- and B-lymphocytes, mast cells;

For obstructive diseases respiratory tract the effect is due mainly to inhibition of inflammatory processes, prevention or reduction of the severity of swelling of the mucous membranes, reduction of eosinophilic infiltration of the submucosal layer of the bronchial epithelium and deposition of circulating immune complexes in the bronchial mucosa, as well as inhibition of erosion and desquamation of the mucosa.

Suppresses the synthesis and secretion of ACTH and, secondarily, the synthesis of endogenous corticosteroids.

Inhibits connective tissue reactions during the inflammatory process and reduces the possibility of scar tissue formation.

The peculiarity of the action is significant inhibition of the pituitary gland function and practically complete absence mineralocorticosteroid activity.

Doses of 1-1.5 mg per day inhibit the function of the adrenal cortex; biological period half-life (duration of inhibition of the hypothalamic-pituitary-adrenal cortex system).

In terms of the strength of glucocorticoid activity, 0.5 mg of dexamethasone corresponds to approximately 3.5 mg of prednisone (or prednisolone), 15 mg of hydrocortisone or 17.5 mg of cortisone.

Easily passes through histohematic barriers (including blood-brain and placental). Metabolized in the liver (mainly by conjugation with glucuronic and sulfuric acids) to inactive metabolites. Excreted by the kidneys (a small part by the lactating glands).

Diseases requiring the administration of fast-acting corticosteroids, as well as cases when oral administration of the drug is impossible:

• endocrine diseases: acute insufficiency of the adrenal cortex, primary or secondary failure adrenal cortex, congenital adrenal hyperplasia, subacute thyroiditis;
• shock (burn, traumatic, surgical, toxic) - if vasoconstrictors, plasma replacement drugs and other symptomatic therapy are ineffective;
• cerebral edema (with a brain tumor, traumatic brain injury, neurosurgical intervention, cerebral hemorrhage, encephalitis, meningitis, radiation injury);
• status asthmaticus; severe bronchospasm (exacerbation of bronchial asthma, chronic obstructive bronchitis);
• heavy allergic reactions, anaphylactic shock;
• rheumatic diseases;
• systemic connective tissue diseases;
• acute severe dermatoses;
• malignant diseases: palliative treatment of leukemia and lymphoma in adult patients; acute leukemia in children; hypercalcemia in patients suffering from malignant tumors, if oral treatment is not possible;
• blood diseases: acute hemolytic anemia, agranulocytosis, idiopathic thrombocytopenic purpura in adults;
• severe infectious diseases (in combination with antibiotics);
• in ophthalmological practice (subconctival, retrobulbar or parabulbar administration): allergic conjunctivitis, keratitis, keratoconjunctivitis without damage to the epithelium, iritis, iridocyclitis, blepharitis, blepharoconjunctivitis, scleritis, episcleritis, inflammatory process after eye injuries and surgical interventions, sympathetic ophthalmia, immunosuppressive treatment after corneal transplantation;
• local application (in the area of ​​pathological formation): keloids, discoid lupus erythematosus, granuloma annulare.

Solution in ampoules for intravenous and intramuscular administration (injections for injections) 4 mg/ml.

Drops ophthalmic Oftan 0,1%.

Ophthalmic suspension 0.1%.

Instructions for use and dosage

The dosage regimen is individual and depends on the indications, the patient’s condition and his response to therapy. The drug is administered intravenously slowly in a stream or drip (for acute and emergency conditions); intramuscularly; local is also possible (in pathological formation) introduction. To prepare a solution for intravenous drip infusion (dropper), you should use an isotonic sodium chloride solution or a 5% dextrose solution.

IN acute period at various diseases and at the beginning of therapy, Dexamethasone is used in more high doses Oh. During the day, you can administer from 4 to 20 mg of Dexamethasone 3-4 times.

Dose of the drug during replacement therapy(with adrenal insufficiency) is 0.0233 mg/kg body weight or 0.67 mg/m2 body surface area, divided into 3 doses, every 3rd day or 0..01165 mg/kg body weight or 0..335 mg/m2 body surface area daily. For other indications, the recommended dose is from 0.02776 to 0.16665 mg/kg body weight or 0.mg/m2 body surface area every hour.

When the effect is achieved, the dose is reduced to maintenance or until treatment is stopped. The duration of parenteral use is usually 3-4 days, then switch to maintenance therapy with dexamethasone tablets.

Long-term use of high doses of the drug requires a gradual dose reduction in order to prevent the development acute failure adrenal cortex.

Conjunctivally, adults and children over 12 years of age in acute inflammatory conditions: 1-2 drops 4-5 times a day for 2 days, then 3-4 times a day for 4-6 days.

Chronic conditions: 1-2 drops 2 times a day for a maximum of 4 weeks (no more).

In post-operative and post-traumatic cases: starting from the 8th day after surgery for strabismus, retinal detachment, cataract extraction and from the moment of injury - 1-2 drops 2-4 times a day for 2-4 weeks; for antiglaucoma filtering surgery - on the day of surgery or the day after it.

Children from 6 to 12 years old with allergic inflammatory conditions: 1 drop 2-3 times a day for 7-10 days, if necessary, treatment is continued after monitoring the condition of the cornea on the 10th day.

Methods of application

Dexamethasone has a pronounced anti-inflammatory effect and at the same time affects all body systems, which, with prolonged use of the drug, can cause undesirable consequences, many of which are irreversible. The maximum duration of corticosteroid therapy is no more than five days with a gradual reduction in dosage to prevent the development of insufficiency of the adrenal cortex, which independently produces this hormone in small quantities.

Dexamethasone injections are prescribed only in extreme cases, often supplementing therapy with vasodilator Eufillin. Such a joint prescription with Eufillin is necessary to neutralize the body’s reaction to Dexamethasone’s ability to stimulate the production of adrenaline, a hormone that constricts blood vessels. Eufillin is usually taken in tablet form and is not discontinued after completion of corticosteroid treatment.

Treatment shows good results complex drugs. Injections are performed in several stages; in the first stage, Dexamethasone is used in combination with an anesthetic and non-steroidal anti-inflammatory drugs. In the second stage, the injection contains an anesthetic combined with vitamin B12. Eufillin with such therapy performs an additional function, increasing blood circulation, which ensures the flow of oxygen to the cells.

For severe pain syndrome due to osteochondrosis, Dexamethasone is used intramuscularly or injections are given into the epidural space, which allows the drug to act at the site of inflammation, increasing the effectiveness of treatment several times. A dropper for osteochondrosis with Dexamethasone is used in combination with the following drugs: sodium thiosulfate, Dexalgin, Eufillin, Milgamma.

Dexamethasone injections are given both intramuscularly and intravenously. The consumption rate of the drug is about 4-20 milligrams per day. You need to inject it three to four times a day, for 4 days. Then they switch to Dexamethasone tablets. The dosage is determined only by a doctor; doing this on your own is highly not recommended. If you experience pain during a Dexamethasone injection, you should apply topically lidocaine in a spray or use lidocaine ointment.

Dexamethasone is also used when injections are given into the joint. A single dose can range from 0.4 to 4 mg. Injections are given no more than 3-4 times a year.

For the treatment of children, intramuscular administration is usually prescribed. They require special doses of injections, which will be approved by the attending physician. Depending on age and disease, dosages range from 7.5 to 167 mcg/kg per day. Typically, Dexamethasone injections are used for the first three days, then continue to be taken in tablet form.

The injection solution is also used to prepare compresses to relieve joint pain. To do this, you need to prepare a mixture of 50 ml of distilled water (or saline solution), 50 ml of Demixide and 1 ampoule (1 ml) of Dexamethasone, in which it is good to moisten a bandage folded in 3-4 layers and apply it to the sore joint.

For an adult, ten milligrams of the medication is prescribed once every 24 hours when starting therapy. Later there is a decrease to four to two milligrams. For effective therapy It is recommended to drink the norm in three equal parts - for better absorption Dexamethasone. An individual dosage is also selected for children, which usually ranges from 8-3 mcg/kg per day.

They can be used every two hours, one drop, after the patient feels better, every four or six hours. Children are recommended to use drops for 10 days, one drop 2-3 times a day.

Contraindications to the use of Eufillin and Prednisolone

In view of large quantity side effects Dexamethosone is contraindicated:

1. Diabetics and people with a latent form of this disease.
2. For blood diseases, leukemia, oncology.
3. People with stomach diseases, pancreatitis.
4. For glaucoma.
5. People with renal failure, and with liver disease.
6. Pregnant and nursing mothers are prescribed when absolutely necessary.

Dexamethasone in the treatment of osteochondrosis is prescribed by the attending physician in the absence of a response to treatment with non-steroidal drugs, and cannot be used without significant indications.

Treatment with a combination of these drugs is carried out for diseases bronchopulmonary system accompanied by bronchial obstruction and respiratory failure:

• bronchial asthma, status asthmaticus;
• chronic obstructive pulmonary disease.

In addition, drugs are used to provide emergency care with heart blockade and asystole, bronchospasm due to anaphylactic shock or pulmonary edema (in small doses).

It will be necessary to select a different treatment if the following conditions exist:

• individual intolerance;
• hyperacid gastritis, peptic ulcer stomach and duodenum;
• arrhythmia with accelerated heart rate;
• increased convulsive activity of the brain;
• decompensated dysfunction of the liver, kidneys and heart;
• bleeding in the brain or retina;
• severe immunodeficiency;
• acute myocardial infarction;
• glaucoma;
• diabetes mellitus;
• diseases of the thyroid gland (thyrotoxicosis, hypothyroidism);
• Itsenko-Cushing's disease;
• myasthenia gravis.

During pregnancy, treatment is prescribed by comparing the benefits for the mother and the risks for the child. Often the consequences of fetal hypoxia are more severe than those of taking these medications.

If after childbirth women with bronchial asthma still need to continue therapy, then for this period breastfeeding it is recommended to interrupt.

For children under 14 years of age, it is advisable to prescribe oral treatment.

The medicine is prescribed in the case of:

• bronchial asthma;
• asthmatic bronchitis;
• chronic obstructive pulmonary disease;
• emphysema;
• the presence of a “pulmonary” heart;
• Pickwick's syndrome (apnea);
• increased intracranial pressure.

Parenteral solution for internal administration is used:

• to relieve asthmatic attacks;
• in case of acute cerebrovascular accident (stroke) and cerebral edema;
• in the presence of left ventricular failure with bronchospasm of the Cheyne-Stokes type;
• in cases of apnea in newborns;
• if there is acute or chronic heart failure;
• to relieve intracranial pressure, as well as pressure in the pulmonary vessels;
• for edema caused by kidney pathologies;
• for neuralgia.

The drug, like any other drug of synthetic origin, has a number of contraindications. Eufillin is not used for:

• some heart diseases (myocardial infarction) and heart rhythm disturbances (arrhythmias, extrasystoles, tachycardia);
• coronary insufficiency;
• epileptic disease;
• gastric and duodenal ulcers in the acute phase;
• exacerbation of gastritis;
• severe pathologies of the liver and kidneys;
• the presence of hemorrhage in the retina of the eye;
• allergies to aminophylline.

For the treatment of neuralgia and osteochondrosis, a dropper of Eufillin with Dexamethasone is used.

Children under 14 years of age, pregnant and lactating women, elderly people, patients with vascular atherosclerosis and prostatic hyperplasia are treated with caution.

Infusion administration of drugs is not indicated for the following diseases and pathological conditions:

• heart failure;
• thrombophlebitis;
• dermatological diseases;
• tendency to edema.

Below we will consider why, for what diseases and conditions, Dexamethasone is prescribed:

• Diseases, injuries and operations of the brain: malignant formations, severe injuries, neuro surgical operations, hemorrhages, radiation damage to the body.
• Lung diseases: severe difficulty breathing, increased asthma symptoms, pneumonia.
• Allergies: anaphylactic shock, severe allergies, toxic allergies.
• Diseases of the cornea of ​​the eye: conjunctivitis caused by allergies, blurred vision due to inflammation of the cornea, inflammation of the iris, bilateral inflammation of the edges of the eyelids, scleritis, inflammation of the cornea with purulent formation, corneal surgery.
• Diseases associated with disorders endocrine glands: adrenal insufficiency, adrenal hyperplasia from birth, thyroiditis.
• Tumors and diseases associated with them: acute disorder hemorrhage in children, hypercalcemia, leukemia, lymphoma.
• For local use: tissue dysregeneration, granuloma annulare, keloid.
• Local or systemic diseases body tissues: systemic lupus erythematosus, scleroderma, mixed diseases fabrics.
• Shock: from burns, injuries, poisoning with various drugs.
• Defeats skin: Stevens-Jones syndrome, erythema, TEN syndrome.
• Heavy infectious diseases: infections caused by viruses, food toxic infections, dysentery.
• Diseases of the musculoskeletal system: osteoporosis, joint diseases, vasculitis.

Despite the wide range of diseases for which Dexamethasone is used, it also has numerous contraindications. So, the drug should not be taken if the patient has:

• intolerance to the components of the drug;
• diseases caused by viruses, infections, fungi: common herpes, amoebiasis, fungal infection skin, obvious or dormant tuberculosis;
• diseases of the digestive system: stomach or duodenal ulcers, inflammation of the esophagus, gastritis, consequences surgical intervention, ulcerative colitis, diverticulitis;
• immunodeficiency states of the body;
• diseases of the endocrine system: diabetes mellitus, hypothyroidism, Itsenko-Cushing syndrome;
• heart and vascular diseases: post-infarction condition, heart failure;
• heavy chronic failure kidney/liver;
• diseases of the skeletal system: systemic osteoporosis, poliomyelitis;
• other diseases: nephroulitiasis, hypoalbuminemia, glaucoma.

Side effects

Taking the drug in excess doses or long time may cause problems at work various organs and vital systems:

• Cardiovascular system: increased blood pressure, baricardia, thrombosis, cardiac arrest.
• Gastrointestinal tract: lack of appetite, decreased digestive function, flatulence, bleeding due to perforation of the stomach walls.
• Endocrine system: glucose tolerance decreases, steroid-type diabetes may occur. Obesity also develops, the function of the pituitary gland decreases, which may lead to growth retardation.
• Nervous system: in a mild form – dizziness, headaches, nervousness, anxiety, sleep disturbance. In severe form, there are hallucinations, depression, euphoria, and psychosis.
• Sexual sphere: cycle disorders in women, sexual dysfunction in men, delayed puberty in adolescents.
• Visual organs: cataract, retinal tear, corneal detachment.
• Reduction of muscle mass with replacement by fat.
• Taking the drug leads to the leaching of calcium from bone tissue and provokes its fragility, which leads to the development of osteoporosis.
• A local reaction to exceeding the dosage of the drug manifests itself in the form of skin rash and allergic urticaria.

This is not a complete list of side effects that occur with prolonged and uncontrolled use of a glucocorticosteroid drug.

The simultaneous use of drugs helps to achieve the following treatment results:

• dilation of the bronchi;
• desensitization;
• reduction of bronchial inflammation;
• reducing swelling of the lung tissue.

At clinical studies Dexamethasone has been found to be well tolerated by most people. However, some may experience the following side effects:

• Manifestations of dormant diabetes;
• Nausea, vomiting;
• Violation of digestive processes;
• Increased appetite;
• Increased blood pressure;
• Nervousness;
• Anxiety;
• Sleep disorders;
• Dizziness/migraine;
• Convulsions;
• Increase in body weight;
• Increased sweating;
• Skin irritation;
• Anaphylactic shock;
• Allergy.

Eufillin, instructions for use in ampoules

The drug is prescribed by a doctor for each patient individually. This takes into account the diagnosis, the patient’s age and weight.

If it is necessary to relieve bronchospasm, intravenous administration of the drug in large quantities is indicated. The medicine is administered through a dropper, the solution for which contains:

• 10-20 ml Euphyllin;
• 10-20 ml of 9% sodium chloride solution;
• 0.5 l of saline solution.

The drug is administered over 30 minutes. For 1 kg of patient weight, 5-6 mg of medication is needed. When introducing a drip, it is necessary to monitor the patient's blood pressure and heart rate.

In order to relieve an attack of bronchial asthma, it is necessary to administer 750 ml of medication using a dropper.

For intravenous administration, Eufillin is mixed with a solution of sodium chloride. The intravenous injection is given slowly, over 6 minutes. With simultaneous treatment with Euphylline and Theophylline, the dosage of the former is reduced by half.

An injection of Eufillin intramuscularly is quite painful. For injections, exclusively thick needles are used. Dosage: single dose - 7 mg/kg, daily dose - 13 mg/kg. The drug is used more than three times a day. The duration of treatment is 14 days.

The medicine is also used for inhalation, which is carried out for bronchospasms and asthmatic attacks in children. To prepare the solution you need:

• Euphyllin ampoule 2.4%;
• three ampoules of Diphenhydramine;
• 150 ml saline solution.

The dosage of the solution is prescribed by the pediatrician, depending on the diagnosis and body weight of the child. A nebulizer is used as an inhaler.

• decreased glucose tolerance;
• steroid diabetes mellitus or manifestation of latent diabetes mellitus;
• suppression of adrenal function;
• Itsenko-Cushing syndrome (moon face, pituitary obesity, hirsutism, increased blood pressure, dysmenorrhea, amenorrhea, muscle weakness, stretch marks);
• delayed sexual development in children;
• nausea, vomiting;
• pancreatitis;
• steroid ulcer of the stomach and duodenum;
• erosive esophagitis;
• gastrointestinal bleeding and perforation of the wall of the gastrointestinal tract;
• increased or decreased appetite;
• indigestion;
• flatulence;
• arrhythmias;
• bradycardia (up to cardiac arrest);
• increased blood pressure;
• hypercoagulability;
• thrombosis;
• euphoria;
• hallucinations;
• manic-depressive psychosis;
• depression;
• paranoia;
• increased intracranial pressure;
• nervousness or restlessness;
• insomnia;
• dizziness;
• headache;
• convulsions;
• promotion intraocular pressure with possible damage to the optic nerve;
• tendency to develop secondary bacterial, fungal or viral infections eye;
• trophic changes in the cornea;
• exophthalmos;
• sudden loss of vision (with parenteral administration in the area of ​​the head, neck, nasal concha, scalp, deposition of drug crystals in the vessels of the eye is possible);
• hypocalcemia;
• weight gain;
• negative nitrogen balance (increased protein breakdown);
• increased sweating;
• fluid and sodium retention (peripheral edema);
• slower growth and ossification processes in children (premature closure of epiphyseal growth zones);
• osteoporosis (very rarely - pathological bone fractures, aseptic necrosis heads of the humerus and femur);
• muscle tendon rupture;
• delayed wound healing;
• steroid acne;
• striae;
• tendency to develop pyoderma and candidiasis;
• skin rash;
• anaphylactic shock;
• local allergic reactions.

Local for parenteral administration: burning, numbness, pain, tingling at the injection site, infection at the injection site, rarely - necrosis of surrounding tissues, scarring at the injection site; atrophy of the skin and subcutaneous tissue with intramuscular injection (injection into the deltoid muscle is especially dangerous).

For short-term use vital signs the only contraindication is hypersensitivity to dexamethasone or the components of the drug.

In children during the growth period, GCS should be used only when absolute indications and under the careful supervision of the attending physician.

Use during pregnancy and breastfeeding

During pregnancy (especially in the 1st trimester), the drug can be used only when the expected therapeutic effect outweighs the potential risk to the fetus. At long-term therapy During pregnancy, the possibility of impaired fetal growth cannot be ruled out. If used at the end of pregnancy, there is a risk of atrophy of the adrenal cortex in the fetus, which may require replacement therapy in the newborn.

If it is necessary to carry out treatment with the drug during breastfeeding, breastfeeding should be stopped.

During treatment with Dexamethasone (especially long-term), observation by an ophthalmologist, monitoring of blood pressure and water-electrolyte balance, as well as peripheral blood patterns and blood glucose levels are necessary.

In order to reduce side effects, antacids can be prescribed, and the intake of potassium into the body should be increased (diet, potassium supplements). Food should be rich in proteins, vitamins, and limit the content of fats, carbohydrates and table salt.

The effect of the drug is enhanced in patients with hypothyroidism and liver cirrhosis. The drug may worsen existing emotional instability or psychotic disorders. If a history of psychosis is indicated, Dexamethasone in high doses is prescribed under the strict supervision of a physician.

It should be used with caution in acute and subacute myocardial infarction - the necrosis focus may spread, the formation of scar tissue may slow down, and the heart muscle may rupture.

IN stressful situations During maintenance treatment (for example, surgery, trauma or infectious diseases), the dose of the drug should be adjusted due to the increased need for glucocorticosteroids. Patients should be carefully monitored for a year after the end of long-term therapy with Dexamethasone due to possible development relative insufficiency of the adrenal cortex in stressful situations.

With sudden withdrawal, especially in the case of previous use of high doses, the development of withdrawal syndrome (anorexia, nausea, lethargy, generalized musculoskeletal pain, general weakness), as well as exacerbation of the disease for which Dexamethasone was prescribed.

During treatment with Dexamethasone, vaccination should not be carried out due to a decrease in its effectiveness (immune response).

When prescribing Dexamethasone for intercurrent infections, septic conditions and tuberculosis, it is necessary to simultaneously treat with bactericidal antibiotics.

In children during long-term treatment Dexamethasone requires careful monitoring of the dynamics of growth and development. Children who, during the treatment period, were in contact with patients with measles or chicken pox, specific immunoglobulins are prescribed prophylactically.

Due to the weak mineralocorticoid effect, Dexamethasone is used in combination with mineralocorticoids for replacement therapy for adrenal insufficiency.

In patients with diabetes mellitus, blood glucose levels should be monitored and therapy adjusted if necessary.

X-ray monitoring of the osteoarticular system (images of the spine, hand) is indicated.

In patients with latent infectious kidney diseases and urinary tract Dexamethasone can cause leukocyturia, which may have diagnostic value.

There may be pharmaceutical incompatibility of dexamethasone with other IV drugs - it is recommended to administer it separately from other drugs (IV bolus, or through another dropper, as a second solution). When mixing a solution of dexamethasone with heparin, a precipitate forms.

Simultaneous administration of dexamethasone with:

• inducers of hepatic microsomal enzymes (phenobarbital, rifampicin, phenytoin, theophylline, ephedrine) leads to a decrease in its concentration;
• diuretics (especially thiazide and carbonic anhydrase inhibitors) and amphotericin B - can lead to increased excretion of K from the body and an increased risk of developing heart failure;
• with sodium-containing drugs - to the development of edema and increased blood pressure;
• cardiac glycosides - their tolerability worsens and the likelihood of developing ventricular extrasytolia increases (due to caused hypokalemia);
• indirect anticoagulants - weakens (less often enhances) their effect (dose adjustment required);
• anticoagulants and thrombolytics - the risk of bleeding from ulcers in the gastrointestinal tract increases;
• ethanol (alcohol) and non-steroidal anti-inflammatory drugs - increases the risk of erosive and ulcerative lesions V gastrointestinal tract and the development of bleeding (in combination with NSAIDs in the treatment of arthritis, it is possible to reduce the dose of glucocorticosteroids due to the summation of the therapeutic effect);
• paracetamol - the risk of developing hepatotoxicity increases (induction of liver enzymes and the formation of a toxic metabolite of paracetamol);
• acetylsalicylic acid - accelerates its elimination and reduces its concentration in the blood (when dexamethasone is discontinued, the level of salicylates in the blood increases and the risk of side effects increases);
• insulin and oral hypoglycemic drugs, antihypertensive drugs - their effectiveness decreases;
• vitamin D - its effect on Ca2 absorption in the intestine is reduced;
• growth hormone - reduces the effectiveness of the latter, and with praziquantel - its concentration;
• M-anticholinergics (including antihistamines and tricyclic antidepressants) and nitrates - helps increase intraocular pressure;
• isoniazid and mexiletine - increases their metabolism (especially in “slow” acetylators), which leads to a decrease in their plasma concentrations.

Overdose

An overdose of Eufillin can manifest itself:

• intestinal or stomach bleeding;
• anxiety and sleep disorders;
• nausea and vomiting with blood discharge;
• tachycardia;
• decreased blood pressure;
• swelling of the face;
• ventricular arrhythmia;
• photophobia;
• convulsions.

If poisoned by the drug, a person may fall into a coma.

In case of drug overdose, you must immediately call an ambulance.

Usually manifests itself with pronounced side effects, listed below. For these negative consequences of therapy, treatment is used individual symptoms, in which it is important to maintain normal functioning human body. There were no reports of deaths or poisoning from overdoses.

Eufillin during pregnancy

Often, pregnant women experience edema, which sometimes cannot be eliminated using conventional methods, that is, the use of diuretics. In this case, Eufillin is prescribed, which, by dilating blood vessels, stimulates the kidneys, helping them remove excess fluid from the body.

The drug is taken during pregnancy with extreme caution and only under the supervision of the attending physician, since in the first two trimesters the internal organs of the unborn baby are formed, and the medicine has the ability to penetrate the placental barrier. The product is used only when absolutely necessary. Start using it with small doses, gradually increasing the amount. Therapy with the drug is prescribed in short courses, no more than a few days. In rare cases, the dose is increased to 1 month.

Indomethacin, displacing dexamethasone from its connection with albumin, increases the risk of developing its side effects.

ACTH enhances the effect of dexamethasone.

Ergocalciferol and parathyroid hormone prevent the development of osteopathy caused by dexamethasone.

Cyclosporine and ketoconazole, by slowing down the metabolism of dexamethasone, can in some cases increase its toxicity.

Simultaneous administration of androgens and steroids anabolic drugs with dexamethasone promotes the development of peripheral edema and hirsutism, the appearance of acne.

Estrogens and oral contraceptives containing estrogen reduce the clearance of dexamethasone, which may be accompanied by an increase in the severity of its action.

When used simultaneously with live antiviral vaccines and against the background of other types of immunization, it increases the risk of viral activation and the development of infections.

Antipsychotics (neuroleptics) and azathioprine increase the risk of developing cataracts when dexamethasone is prescribed.

When used simultaneously with antithyroid drugs, the clearance of dexamethasone decreases and with thyroid hormones increases.

Analogues of the drug Dexamethasone

Structural analogues of the active substance:

• Decadron;
• Dexaven;
• Dexazone;
• Dexamed;
• Dexamethasone Bufus;
• Dexamethasone Nycomed;
• Dexamethasone-Betalek;
• Dexamethasone Vial;
• Dexamethasone-LENS;
• Dexamethasone-Ferein;
• Dexamethasone sodium phosphate;
• Dexamethasone phosphate;
• Dexamethasonelong;
• Dexapos;
• Dexafar;
• Dexon;
• Maxidex;
• Oftan Dexamethasone;
• Fortecortin.

This medicine can be prescribed during pregnancy only if the therapeutic effect is much higher than the risk to pregnancy. The type of medicine and dosage is determined by a specialist. However, with long-term therapy, it has previously been observed that the possibility of fetal growth retardation cannot be ruled out. In the third trimester, the prescribed drug may cause developmental delays or the appearance of pathologies in the unborn child.

If treatment with this medication is required during lactation, it should be stopped and the child should be switched to dry formula.

Alcohol compatibility

Most medications are incompatible with alcohol consumption. Eufillin is one of these medications. Aminophylline can enhance the effect of many chemicals, in particular alcohol. When used simultaneously with alcohol, the drug may cause:

• a sharp decrease in blood pressure, up to collapse;
• symptoms of suffocation;
• disturbance of heart rhythms (arrhythmia, tachycardia, palpitations);
• relaxation of the lung muscles, which may impair respiratory function;
• bleeding in the brain if the blood vessels are weakened.

Rarely, simultaneous use of alcohol and Eufillin can be fatal.

Interaction with other drugs

The drug is incompatible with medications containing any acids. Combined use with certain types of antibiotics may enhance the effect of Eufillin, therefore, the dosage of the latter will need to be reduced. If you take the drug with Dexamethasone or Prednisolone, side effects may increase.

Medicines such as Carbamazepine, Diphenin, Sulfinpyrazone, Phenytoin, Phenobarbital, etc., reduce the effect of aminophylline, therefore, its dosage is increased when taken simultaneously with these drugs.

The simultaneous use of Eufillin with diuretics and beta-agonists enhances the effect of the latter. The drug reduces the effectiveness of beta-blockers and lithium preparations.

With the help of these medications, the inflammatory process is eliminated. Also, these medications most effectively eliminate pain. When administering non-steroidal anti-inflammatory injections, the result occurs much faster than when using tablets and ointments.

Most often, these medications are used in injections if a person’s immune system becomes overactive. This pathological condition leads to tissue and joint damage.

Attention! Non-steroidal drugs are prescribed when an inflammatory process occurs, as well as to eliminate pain. With their help it is impossible to eliminate the disease.

Introduction medications the patient can be administered intravenously or intramuscularly. Injections are given in any place that is as close as possible to the location of the hernia. This injection method allows us to guarantee a 100% effect of drugs on the disease.

mixing drugs in one syringe

Is it possible to mix dexamethasone, lidocaine and B12 in one syringe?

Dear Natalya Vasilievna! Clinical pharmacology warns about the possibility of pharmaceutical incompatibility between Dexamethasone and other drugs used for intravenous and intramuscular administration. When two or more medications are mixed in one syringe, they may interact like different chemicals, with subsequent inactivation and loss of their properties, or a weakening and even distortion of the therapeutic effect.

In the case you described, one of the methods is to carry out a therapeutic lidocaine blockade, and then administer a Dexamethasone solution. At the same time, perhaps your attending physician has information from reliable sources that the mixture of Lidocaine and Dexamethasone solutions is not accompanied by incompatibility of its components.

↓↓0 Kumalagova Natalya Mitrofanovna (/) 02 Feb ““#35”” Reply

Please help me about the pain in the middle of nowhere, no doctors can help from November to March, I’m doing injections for the pain, it’s hellish, the size of the ridge is 7 mm

7 years ago cured without surgery intervertebral hernia“CARIPAZYME”. And then I lifted the weight incorrectly - pain in the lower back (vertebrae L5-S1). I was injected with dexamethasone, lidocaine and B12 in one syringe for 5 days, I didn’t feel any pain at all. I didn’t observe any side effects.

Dear Evgeniy Ivanovich! It is always pleasing when a patient feels better as a result of treatment. Nevertheless, clinical pharmacology, which is one of the fundamental medical disciplines, does not recommend mixing Dexamethasone solution with solutions of other drugs.

Hello! If such a triad helps many people, it is not clear why you are talking about incompatibility? About individual intolerance- that's another matter! I used this triad for myself, my beloved) My husband, my mother! I went for a consultation with a surgeon at the regional hospital

For a consultation! Still, to my mother, to the old man, he answered that we were doing everything right! But not 3, but 5 days can be set! And then we’ll plant or declofinac. That’s what we did! Everyone was in trouble!

Dear Lyudmila! This is not about pharmacological, but about pharmaceutical compatibility of drugs. These drugs are pharmacologically compatible with each other, their combination is justified and gives the expected clinical effect. At the same time, the instructions for medical use of Dexamethasone clearly and directly state the pharmaceutical incompatibility of the drug with other drugs, and the need for its administration separately from them.

Each of the drugs is a chemical substance with a rather complex structure. When they are mixed, a chemical reaction is possible, which is not accompanied by a change in color or transparency of the solution, but at the same time chemical formula changes, the medicine may lose its effect, or, conversely, become unsafe for the body, irritating tissues and causing the formation of post-injection abscesses and infiltrates.

In order to know for sure the consequences of mixing two or more chemicals, you need to be a highly qualified chemist. Even the most experienced competent doctors are so deep knowledge in the field of organic and inorganic chemistry, as a rule, do not have, for this you need a corresponding full-fledged profile higher education, at least - the chemistry department of the university.

Hello, Evgeniy Ivanovich! I have a hernia of the same vertebrae as you. The pain is unbearable. Please tell me how you gave the injections. i.e. which medicine was drawn into the syringe first. And if I understand correctly, then one injection a day? And also tell me how you were treated with KARIPAZIM? Thanks in advance for your answer.

Pyridoxine is incompatible with nicotinic acid. Their interaction with each other leads to the decomposition of pyridoxine. Pharmaceutical incompatibility is a weakening, loss or distortion of the therapeutic effect of drugs or an increase in their side and toxic effects during interaction. Combine pyridoxine and nicotinic acid it is forbidden.

The cat broke his paw and prescribed medications: lincomycin, diphenhydramine-vial, dexamethasone, administered twice a day for 5 days. Question: can these drugs be combined into one syringe?

Dear Maria Vasilievna! There is no need to do this. Moreover, I advise you to space the injections over time, that is, give injections at intervals of an hour and a half. Every drug is complex chemical compound, and their interaction when mixed is almost always inevitable, even if the mixture remains transparent, and the result of this chemical reaction not always desirable.

There are combinations of drugs that are administered in one syringe and are used successfully, but this does not apply to the medications you listed. Lincomycin is administered twice a day, this is required by the pharmacodynamics of the drug. Dexamethasone - can be used once in the morning, Diphenhydramine - once in the evening. BUT - this is ONLY as prescribed by the veterinarian who is treating your cat.

please tell me, is it possible to mix voltaren and dexamithasone in one syringe?

Is it possible to mix atropine and diphenhydramine in one syringe? Is the effect of this premedication reduced? and is it possible to mix atropine, diphenhydramine and etamsylate?

Hello, Anastasia! Atropine should not be mixed with other drugs. For premedication, atropine is given subcutaneously, diphenhydramine is administered into the muscle. In general, this is the prerogative of anesthesiologists or other specialists with medical education, as well as veterinarians.

Tell me if it is possible to mix thiamine vial and pyridoxine vial in one syringe. Thanks in advance.

Hello, Maria Ivanovna! The instructions say that this is highly undesirable. Even if the syringes are different, but the injections coincide in time, this will also not be beneficial. Pyridoxine inhibits the conversion of thiamine to its biologically active form

Good morning! My dog ​​was prescribed a blockade - lincomycin 30% 0.5 ml B12 0.6 ml (from mlg) dexamethasone 0.3 ml lidocaine 2% 1.5 ml novocaine added to 6 ml, all in one syringe and placed subcutaneously. Please tell me is this correct?

Dexamethasone (sodium phosphate) 8 mg IV drip in one system and then follow this with IV drip through this bottle and syringe in one together

Calcium Glucanate 10 mg IV drip all together in one syringe

Cefamed dividing into two x 2 times a day IM

Is this how you can treat a 14 year old girl weighing 49 kg, height cm?

The doctors treated my little sister this way, please give me an answer?

↓↓0 Torebekova Zulpiya Shamsiddinovna (0 / 2) 05 Sep ““#18”” Reply

Dear Zulpiya Shamsiddinovna! Give expert assessment the correctness of the therapy can only be based on a thorough study of all medical documentation. I recommend that you contact the head of the department where the patient is (or was) being treated, or the deputy chief physician of the hospital for medical work.

• Barbiturate; Rifampicin - accelerates metabolism;
• Antacid - reduces the absorption of the drug, but reduces the risk of side effects;
• Hormonal contraceptives - complement the effect of Dexamethasone, but reduce its own;
• Lidocaine, incl. during blockade, - in combination with Dexamethasone, it has a more pronounced and prolonged effect;
• B12 - its additional use is always required during Dexamethasone therapy;

• Diclofenac - increases the risk of gastrointestinal bleeding;
• Indirect anticoagulants - their effect can be either weakened or enhanced, so dosage control is needed;
• Active antiviral vaccines and other methods of artificially increasing immunity - the risk of disease increases;
• Glycosides and diuretics - risk of arrhythmia and hypokalemia;
• Preparations containing sodium - risk of edema;
• Amphocetrine B/carbonic anhydrase inhibitors - lead to heart failure and deterioration of bones and muscles;
• Cardiac glycosides - potassium deficiency;
• Eufillin ( intravenous injections) - increases the possibility of the onset of side effects of the drug.

Features of the use of Eufillin

Intravenous administration of the drug is carried out subject to certain conditions:

• before use, the medicine must be heated to human body temperature;
• begin administration with a minimum dosage, gradually increasing it;
• the drug is not diluted with glucose solution;
• During administration, strict monitoring of the patient's blood pressure and pulse is necessary. If they change, it is necessary to reduce the rate of administration;
• when administering large doses, monitor the content of Euphyllin in the blood. If necessary, the dosage of the medication is reduced.

During drug therapy, you should refrain from carrying out work that requires maximum concentration of attention, as well as from driving vehicles.

Price for the drug in the pharmacy chain

The price may vary depending on the pharmacy chain and its location.

Eufillin's analogs

Analogs of the drug that have an identical effect:

• Aminophylline;
• Prednisolone;
• Tizol;
• Berodual et al.

Dexazone - contains the same active ingredient, is available in the form of a solution in packages of 5 ampoules - the cost is about 200 rubles. It can also be found in the form of tablets, 50 pieces per pack - from 50 rubles. It has fewer side effects with short-term therapy, but the indications are similar to Dexamethasone.

Dexamed - also contains dexamethasone, sold in 100 pieces in dark glass ampoules. Cost rubles per package.

Decadron - available in the form of injection ampoules. The cost of the medicine in ampoules is about 250 rubles for 5 ampoules per package.

Dexamethasone Vial has many more indications for use than Dexamethasone. Sold only in the form of injection solutions in packs of 5 ampoules. The cost of the drug is from 135 rubles per package.

Maxidex - analogue eye drops Dexamethasone, sold in 5 ml bottles, price - from 186 rubles. It has the same main substance as Dexamethasone.

Oftan Dexamethasone - eye drops with similar active substance. The cost is about 200 rubles per 5 ml bottle.

Dexapos is an analogue of Dexamethasone in the form of eye drops. They have a healing effect for up to 8 hours, in which they are much superior to their counterparts. The cost is about 150 rubles per 5 milliliter bottle.

The cost of Dexamethasone is not so high that we need to look for drugs similar to it. But sometimes there is a need for this, especially if you are not satisfied with the side effects of the medicine. In this case, you should contact your doctor so that he can find a good alternative for you.

Special instructions

In connection with the above side effects, it is worth saying that if there is certain diseases You should have your health monitored by different specialists. The drug should be taken only with a prescription; you cannot replace the medicine with analogues yourself. The dosage of the medicine may be reduced if it is discovered that side effects are developing diseases.

Dexamethasone can increase a person’s psychological instability, so it is not suitable for treating patients with acute psychosis and other severe psychoneurological diseases. If psychosis is detected, the dosage of the drug is administered only under the supervision of a physician.

You should not suddenly complete the course; it may cause withdrawal syndrome or exacerbation of existing diseases. At the same time, there are elevated temperature body, muscle pain, arthralgia and general deterioration state of the body. Doctors recommend withdrawing from therapy gradually under strict supervision from a specialist.

What diseases require careful monitoring by specialists?

Also, in order not to miss the development of side effects, it is necessary to constantly carry out preventive measures, including:

• Observations from an ophthalmologist when using the medicine in the form of drops;
• Blood pressure control (possibly independent);
• Taking blood tests;
• Consumption of vitamins K and B12 (as prescribed by a general practitioner);
• Saturation of the diet with proteins;
• Limiting the consumption of fats, carbohydrates and salts (you can contact a nutritionist to create a diet and get it approved by a gastroenterologist).

What is the drug "Eufillin"? We will provide reviews about this medication, its indications, methods of use and side effects in this article. You will learn about the form in which this medicine is sold and what its price is.

General information

The drug "Eufillin", reviews of which are very varied, is a bronchodilator drug. This medication belongs to the group of xanthines. It can be purchased at almost any pharmacy, but it is advisable to use such a drug for medicinal purposes only as prescribed by a doctor.

Forms of release and composition of the drug

Currently, the drug can be purchased in two different forms, namely:

• In tablets that contain 150 mg of the active ingredient aminophylline. This drug is sold in cardboard packaging of 50, 10, 30 or 20 pieces.
• The drug "Eufillin" in ampoules. 2.4% solution for injection (1 ml) contains 24 mg of aminophylline.

Only your attending physician should recommend which form of medication to use to treat a particular disease.

Properties of the drug

As mentioned above, the drug “Eufillin” in ampoules or tablets contains the main substance - aminophylline. In turn, this component is a mixture that consists of 80% theophylline and 20% ethylenediamine. This composition significantly facilitates the solubility of the drug and also significantly improves its absorption.

What is the drug "Eufillin" prescribed by doctors for? The indications of this remedy are due to its effect on the bronchi. Thus, the medicine “Eufillin” is able to relax the mentioned organ and eliminate spasms that have arisen in them. It quite effectively improves the functioning of the epithelial cilia of the respiratory tract, and also increases the contraction of intercostal, diaphragmatic and other muscle tissues.

What is special about the drug "Eufillin"? Reviews from patients say that this medication can stimulate respiratory center in the medulla oblongata, as well as improve pulmonary ventilation, saturate the blood with oxygen and reduce the content of carbon dioxide in it, that is, normalize respiratory functions.

The principle of action of the medication

The mechanism of action of the presented drug is that it inhibits the enzyme phosphodiesterase, due to which cyclic adenosine monophosphate accumulates in the tissues, and also reduces the flow of calcium ions into the cells that are responsible for muscle contraction, which relaxes the smooth muscles of the bronchi.

It should also be noted that the drug "Eufillin" (ampoules, tablets) is capable of stimulating cardiac activity by increasing the frequency and force of myocardial contraction. It lowers the tone of blood vessels in organs such as the kidneys, brain and skin.

By having a relaxing effect on the walls of the veins in the pulmonary circulation, this medication helps to lower the pressure in it. The use of the drug "Eufillin" significantly improves blood supply to the kidneys. Thanks to this, the formation and, accordingly, the excretion of urine significantly increases. The drug helps to slow down. It cannot be said that “Eufillin” makes red blood cells resistant to damage. In other words, it significantly improves blood flow.

It is also known about the tocolytic effect of this drug on the uterus. It can also increase the acidity of gastric juice.

Absorption and excretion

The drug "Eufillin" - what is it used by patients for? Before answering the question, it should be said that this medication is quite well absorbed from the digestive system. Its bioavailability reaches almost 100%, although when taken simultaneously with food, the absorption of the drug can noticeably slow down.

This medication penetrates into the milk of a nursing mother and does not stop at the placental barrier. Metabolism of the drug occurs exclusively in the liver. Its elimination from the human body is carried out through the kidneys.

Medicine "Eufillin": indications for use

The drug "Eufillin" is prescribed for obstructive chronic bronchitis, to relieve attacks of bronchial asthma (in patients with asthma physical stress and as additional means in other forms), in status asthmaticus (only in combination therapy), heart failure, complex treatment of stroke, as well as others ischemic conditions brain, angina pectoris, Cheyne-Stokes breathing, emphysema, pulmonary edema and other abnormalities that are associated with congestion. According to patient reviews, the drug "Eufillin" (solution for and tablets) effectively lowers blood pressure during hypertensive crisis. It is quite often used for apnea treatment newborns, that is, with a condition that is characterized by periodic cessation of breathing (for 15 seconds), and is accompanied by such abnormalities as bradycardia and cyanosis.

Contraindications for use

The drug "Eufillin" (indications for the use of this drug include many exceptions) has a large number of contraindications.

So, the presented medication is highly not recommended for use for treatment if you experience at least one of the following phenomena:

Instructions for use

In the form of a solution, this drug is administered intramuscularly or intravenously. It should be especially noted that parenteral use This drug is used only for urgent and emergency conditions. In this case, the dosage of the drug should be calculated individually and depend on the rate of excretion in the patient. different people, the severity of the patient’s condition and his body weight.

What rules should you know in order to administer the drug “Eufillin” intravenously? The dropper with the medicine must be placed very carefully, and most importantly, slowly.

According to the instructions, for adults in emergency situations, the dosage of this drug is selected at the rate of 6 mg per 1 kg of weight. To do this, the drug must be diluted in 20 ml of physiological sodium chloride solution and administered intravenously. The injection is carried out very slowly (over 5-8 minutes).

If the patient has status asthmaticus, he is prescribed an infusion of the drug in the amount of 720 or 750 mg. The duration of such therapy should not exceed 14 days.

To alleviate the patient’s condition with obstructive pulmonary diseases (especially in the acute phase), the administration of the drug begins with a dosage of 5 or 6 mg per 1 kg of patient weight. If necessary, it can be increased. However, this should be done extremely carefully, monitoring the blood picture.

As for tablets, in this form “Eufillin” is prescribed 0.15 g after meals once or three times a day. The course of treatment can last several days or months.

For neonatal apnea, the initial dosage of this drug is 5 mg per 1 kg of body weight per day (in 2 doses). In this case, the drug is administered after improvement of the condition, you should switch to maintenance therapy (2 mg per 1 kg per day in 2 divided doses). The duration of treatment for the disease can be several weeks or months.

For younger and older children, the drug is prescribed depending on the indications and severity of the condition. Daily dosage varies between 6-15 mg per 1 kg of weight.

Inhalation with "Eufillin"

The drug is indispensable for obstructive bronchitis. This is due to the fact that it facilitates the removal of sputum and dilates the bronchial vessels well. In physiotherapy rooms, which are located in each clinic, inhalation procedures are carried out based on a large volume of this drug. So, for 3 ampoules of medication you need to use 10 ampoules of Diphenhydramine, as well as 500 ml of water. If a conventional compressor nebulizer is used for treatment, then this dosage will be much less, although the proportions should remain the same.

Before diluting and using Eufillin for inhalation for a baby, you should definitely consult a pediatrician.

Possible side effects

According to reviews, the drug "Eufillin" can cause such undesirable effects as dizziness, insomnia, excessive agitation, constant headaches, arrhythmia, low blood pressure, abdominal pain, increased heart rate, nausea, heart pain, heartburn, allergic reactions, vomiting , diarrhea, decreased blood glucose, increased sweating, changes in urine tests.

Special instructions

In what cases should you take Eufillin with extreme caution? Reviews from experts indicate that this drug should be used only as prescribed by a doctor and strictly under his supervision, especially if the patient has a fever of unknown origin. Elderly persons should take the drug with extreme caution.

It should be noted that the drug "Eufillin" is capable of increasing the level of uric acid in urine. During use of this medication must be observed special caution at simultaneous use a large number of foods and drinks containing caffeine.

Drug interactions

• When used simultaneously with this medication, the bronchodilating effect of Salbutamol and Terbutaline is noticeably enhanced.
• Simultaneous use of the drug "Eufillin", the price of which does not exceed 40 Russian rubles, with beta blockers can quite easily cause bronchospasms.
• When using this remedy, it should be borne in mind that its effect is noticeably enhanced if simultaneously treated with drugs such as Erythromycin and Cimetidine, as well as taking an influenza vaccine and using oral contraceptives.
• The level of concentration of this drug in the blood decreases when used simultaneously with the drugs Carbamazepine, Rifampicin and Phenytoin.

This degenerative disease (osteochondrosis) affects individual segments of the spine and requires long-term complex treatment. The use of medications aimed at:

To date, no medicine has been developed that could provide a comprehensive effect on the causes and manifestations of the disease. Therefore, it is necessary to use several groups of medications:

• antispasmodics;
• vasodilators;
• normalizing blood circulation;
• immunomodulators;
• specific means to improve metabolic processes in cartilage tissue.

Some of these drugs for osteochondrosis are administered intravenously using droppers.

The essence of the procedure

Many people mistakenly believe that drip administration of the drug is prescribed for in serious condition patients. In fact, the use of infusions is determined by specific indications. What is a dropper?

The drip is placed at emergency assistance

This is a plastic tube, in the middle part of which there is a small reservoir for the solution, and at the ends there are two needles. One of them is inserted into a bottle of medicine, and the second is injected into a vein. The dropper is equipped with a pipette through which the drug drips into the end of the tube directed towards the vein. The health worker performing the procedure can monitor the speed of movement of the medicine and regulate it using a special device that compresses from the outside top part tubes.
When adjusting the drip, it is necessary to create a certain level of liquid medicine at the bottom of the reservoir to prevent air from entering it, which can then enter the vein.
Another long needle is inserted into the bottle to allow air to enter: without it, the drug cannot enter the tube. One more important point is the need to locate the reservoir above the level of the vein into which the solution will be injected. For this reason, the dropper is suspended on a special stand.

In what cases is drip administration of the drug prescribed?

When administered normally, many medications are quickly broken down in the body or eliminated, which prevents the achievement of the necessary therapeutic action.

Some drugs need to be administered by infusion

1. For osteochondrosis, a dropper is prescribed in cases where it is necessary for the drug to be in the blood in a certain constant concentration. It should not be too high so as not to lead to side effects. However, the other extreme must also be avoided: too low a concentration of the product: in this case, the effect will not be achieved. When administered by drip liquid product enters the bloodstream gradually, evenly, over a fairly long period of time.
2. A drip for osteochondrosis is also placed if emergency assistance is necessary - for example, in the event of an exacerbation of the disease or the development of severe pain. With this method of administration, the active substances have a faster and more pronounced effect. The doctor monitors the effect of the drug and can decide whether to increase the dose, reduce it, or stop the drug altogether.
3. Some drugs are intended specifically for drip administration. When used differently, they do not have the proper effect.

Contraindications

Infusion administration of drugs is not indicated for the following diseases and pathological conditions:

• heart failure;
• thrombophlebitis;
• dermatological diseases;
• tendency to edema.

Drip administration of mixtures of drugs for osteochondrosis

One of the most important components Treatment of osteochondrosis is the use of painkillers. They are prescribed a course. In most cases, analgin, sedalgin, and paracetamol are used. In case of a severe attack in the first days, patients are administered mixtures of medications, which include:

• analgesics;
• decongestant (dehydrating) drugs;
• anti-inflammatory;
• muscle relaxants;
• sedatives.

Actovegin for droppers

1 or 2 ml of a 50% solution of analgin and painkillers of other groups (5-10 ml of baralgin, 20-100 ml of a 0.5% solution of novocaine) in most cases are prescribed with 20-40 ml of hydrocortisone, 10 ml of a 2.4% solution of aminophylline, 20-40 mg of Lasix, 1-2 ml of tranquilizers (for example, Relanium), up to 2000 mcg of vitamin B12. For osteochondrosis, droppers with these mixtures in various optimally compatible combinations are recommended twice a day.

Novocaine and its derivatives are used in various dilutions:

• sovcaine – 0.5-10%;
• trimecaine – 0.5-0.25%;
• lidocaine – 0.5, 1 or 2%.

For osteochondrosis, infusions of the following mixtures are most often used:

• 50% analgin solution + no-spa + lasix + 0.25% novocaine solution + saline solution;
• baralgin + relanium + dexazone + novocaine + glucose;
• 50% analgin solution + 2% no-shpa solution + reopirin.

Decongestant, or dehydrating, complexes are prescribed mainly for severe radicular syndrome. In many cases, it is advisable to use saluretics fast action or dexazone. There is no consensus among experts regarding the effectiveness of these medications.

Commonly prescribed drip medications

Actovegin

The drug is a hemoderivative obtained by dialysis and ultrafiltration. It contains 30% organic compounds (amino acids, lipids, etc.), as well as trace elements.

For osteochondrosis, droppers with Actovegin are prescribed to improve trophism and stimulate the processes of regeneration of damaged tissues.

The drug stimulates the active consumption of oxygen and glucose, thereby increasing energy potential cells and regulates neuronal metabolism. Improving oxygen diffusion in neuronal structures helps reduce the severity of trophic disorders.

Dropper with Actovegin

Actovegin stimulates peripheral microcirculation, vasodilation (expansion of the lumen of blood vessels), aerobic energy exchange of vessel walls and releases prostacyclin. Thanks to this action, swelling of the affected area, hypoxia and microcirculation disorders in the area of ​​compression of the nerve root are reduced.

For osteochondrosis, Actovegin can be administered intravenously using a dropper. The dosage ranges from 250 to 500 ml per day. The recommended infusion rate is approximately 2 ml per minute. The full course consists of 10-20 infusions. Since there is a potential risk of developing an anaphylactic reaction, it is better to conduct a test before the procedure.

Contraindications

Droppers with Actovegin are not prescribed for:

• hypersensitivity to the components of the drug;
• decompensated heart failure;
• pulmonary edema;
• anuria;
• oliguria;
• tendency to edema.

For osteochondrosis, this drug is prescribed to improve microcirculation and rheological properties of blood. It has an indirect vasodilating effect and helps eliminate circulatory disorders.

Trental injection solution

The solution can be administered using a dropper or a stream. Ringer's solution, 5% glucose solution or 0.9% sodium hydrochloride solution are used as a solvent for preparing the infusion composition. The dose of trental ranges from 100 to 600 mg 1-2 times a day. The duration of the infusion is determined depending on the dosage and volume of the injected product. The minimum duration of administration of 100 ml of trental is 1 hour. If the symptoms of osteochondrosis are severe, due to significant circulatory impairment, a 24-hour infusion may be prescribed. In such cases, the dosage is determined at the rate of 0.6 mg per hour per 1 kg of patient body weight. Regardless of the severity of the osteochondrosis clinic and the patient’s body weight, the daily dose cannot exceed 1200 mg. As a rule, the maximum volume of solution for infusion is 1.5 liters per day.

Contraindications

Droppers with trental are not prescribed for:

• bleeding tendency;
• hemorrhagic stroke;
• retinal hemorrhage;
• pregnancy.

The drug is prescribed with caution if the patient has the following diseases and pathological conditions:

• atherosclerosis of coronary and cerebral vessels in severe form;
• arrhythmia;
• coronary heart disease;
• gastrointestinal diseases;
• frequent fluctuations in blood pressure.

The product improves peripheral and cerebral circulation, eliminates muscle spasms, has an analgesic effect. Its use in osteochondrosis is mainly due to the last two properties.

Eufillin capsules for dropper

For drip administration, a solution of aminophylline (10-20 ml) is diluted with an isotonic solution of sodium hydrochloride (100-150 ml) 100-150 ml. The rate of administration should be from 30 to 50 drops per minute.
The maximum single dose of the drug is 0.25 g, daily dose is 0.5 g.

Contraindications

Droppers with aminophylline for osteochondrosis are not indicated for the following concomitant diseases:

Droppers with vinpocetine are prescribed for. This medicine helps to correct cerebral circulatory disorders, which occur quite often in this form of the disease. Vinpocetine dilates blood vessels and has an antihypoxic effect due to increased transport of oxygen and glucose. However, it does not have a pronounced effect on the heart and peripheral circulation. The active substance selectively affects the affected areas and improves brain metabolism.

At cervical osteochondrosis Vinpocetine is administered using a dropper. Maximum speed infusion is 80 drops per minute.

The initial dosage should not exceed 20 mg per day, or 2 ampoules. The concentrated product is diluted with a solution for intravenous administration.

In the future, the dose can be increased to 50 mg per day. Course duration is 10-14 days.

Ozone drippers

For osteochondrosis, droppers with ozonated saline solution are also quite effective. In this case, a composition with a fairly low ozone concentration is used. This method provides long action on the internal environment of the body.

Ozonostat device

The procedure allows you to:

• normalize metabolic processes;
• improve microcirculation;
• restore oxygen transport;
• dilate blood vessels;
• reduce the severity of the inflammatory process;
• strengthen the immune system.

Drip administration of ozonized saline solution is carried out in two ways:

• infusion against the background of continuous bubbling - in this case, the solution remains saturated throughout the entire procedure;
• infusion with cessation of bubbling during the procedure - in this case, the dose that the body receives in 30 minutes is equal to 67% of the dose received with continuous bubbling.

Contraindications

Ozone drip administration is not prescribed for:

• acute phase of myocardial infarction;
• allergies to ozone;
• low blood clotting;
• internal bleeding;
• thyrotoxicosis;
• thrombocytopenia;
• hypotension;
• hypoglycemia;
• acute pancreatitis.