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Mildronate is a medicinal product that improves metabolism and energy supply in tissue and cellular level in all organs. Mildronate is used to eliminate the lack of energy and accelerate metabolism in tissues in various chronic diseases and functional disorders, such as coronary heart disease, heart failure, myocardial dystrophy, retinopathy, bronchial asthma, chronic bronchitis, alcohol withdrawal syndrome, reduced mental and physical performance, overstrain and circulatory disorders in the brain and retina.

Names, release forms, composition and dosages of Mildronate

Mildronate is currently available in three dosage forms Oh:
1. Capsules for oral administration;
2. Syrup for oral administration;
3. Solution for injection (intramuscular, intravenous and parabulbar).

All three dosage forms of Mildronate contain the same active substance - meldonium. This active substance is also called mildronate or trimethylhydrazinium propionate dihydrate. Some instructions for use attached to the drug indicate the name of the active substance (INN) meldonium, others - mildronate, and still others - trimethylhydrazinium propionate dihydrate. However, in all cases we're talking about about the same chemical substance, which is designated by different names.

Mildronate capsules contain gelatin, titanium dioxide, silicon dioxide, calcium stearate and potato starch as excipients. The injection solution does not contain any excipients, since it contains only meldonium and purified water. Mildronate syrup contains the following excipients:

• Methyl parahydroxybenzoate;
• Propyl parahydroxybenzoate;
• Propylene glycol;
• Glycerol;
• Citric acid monohydrate;
• Cherry essence;
• Allura Red dye (E129);
• DyeBrilliant Black BN (E151);

Capsules are available in two dosages - 250 mg and 500 mg of meldonium. The syrup contains 250 mg of meldonium per 5 ml, that is, it has a concentration of 50 mg/ml. And the injection solution contains 100 mg of meldonium in 1 ml (100 mg/ml).

Mildronate capsules are often called tablets. However, since the drug does not have such a dosage form, the term “tablets” means a type of Mildronate for oral administration, and these are capsules. Therefore, in this case, capsules = tablets. To indicate the required dosage of capsules is usually used short titles, such as Mildronate 250 And Mildronate 500, where the number corresponds to the dose of the active substance. To designate a solution for injection in everyday life, short forms of names are often used, such as Mildronate injections And Mildronate ampoules.

Therapeutic effect of Mildronate

Mildronate improves metabolism and energy supply to tissues, and due to this has the following therapeutic effects:

• Cardioprotective effect – protecting heart cells from negative influences and improving their viability;
• Antianginal effect – reduction in the oxygen needs of myocardial cells (due to this effect, myocardial cells have enough of even a small amount of oxygen supplied under ischemic conditions, which reduces the severity of pain, reduces the frequency of angina attacks and increases the tolerance of physical and emotional stress);
• Antihypoxic effect – reducing the negative impact of oxygen deficiency;
• Angioprotective effect – protection and ensuring the integrity of the walls of blood vessels;
• Tonic effect.

In addition, Mildronate dilates blood vessels and normalizes cellular immunity, which increases the body's resistance to viral infections.

Mildronate injection solution is available in one concentration of 100 ml/ml and is intended for intravenous, intramuscular or parabulbar administration. That is, the same solution is used for any type of injection.

Ampoules with solution should be opened immediately before injection. Do not store the opened solution either outdoors or in the refrigerator. If the ampoule with the solution was opened in advance and stood for more than 20 minutes, then this drug cannot be used, it should be thrown away and a new ampoule should be opened.

Before opening the ampoule, you should carefully inspect the solution for cloudiness, flakes and other inclusions. If there are any, then the solution cannot be used. For injections, only a clean and completely transparent solution can be used.

Injections must be done in the first half of the day, since Mildronate has a stimulating effect. If you need to make several injections a day, then the last one should be given at least 4 - 5 hours before going to bed.

Intramuscular injections can be done independently at home, and intravenous and parabulbar injections only in a clinic or hospital. Intravenous injections Only a qualified nurse can do this at home.

Dosages and rules for administering Mildronate intramuscularly and intravenously

Dosages, frequency of injections and duration of use of the solution for intravenous and intramuscular administration of Mildronate are the same. The choice of injection method - intravenous or intramuscular - is determined mainly by the required speed of obtaining a clinical effect.

So, if it is necessary for the drug to act quickly and the effect to occur within a short period of time, then the solution is administered intravenously. This is usually necessary for acute conditions. If you need to ensure a long-term effect of the drug with not very rapid development clinical effect, the solution is administered intramuscularly. This is usually justified when treating chronic conditions. Thus, we can briefly summarize that intravenous injections are used for acute conditions, and intramuscular injections are used for treatment chronic diseases. Parabulbar injections are used only in the treatment of eye diseases.

The standard dosage of solutions for intravenous and intramuscular injections is 500 mg per day (5 ml of solution), and for parabulbar injections - 50 mg per day (0.5 ml). However, these dosages may vary depending on the severity of the person's condition and the type of disease for which the drug is being used. Let's consider the dosages, frequency and duration of intravenous and intramuscular injections of Mildronate for various diseases and conditions.

At unstable angina or myocardial infarction Mildronate should be administered intravenously at 500–1000 mg (5–10 ml of solution) per day. This dosage can be administered at one time or divided into two. That is, if a person does not tolerate injections well, then it is better to administer the entire daily dosage of 500–1000 mg at once. If a person tolerates intravenous injections normally, then it is better to divide the daily dosage equally into 2 parts and administer a solution of 250–500 mg twice a day.

Injections are only necessary for one day, after which the person can be switched to taking Mildronate in the form of tablets or syrup. However, if for some reason a person cannot take tablets or syrup, or their effectiveness is low due to diseases of the digestive tract, then the further course of treatment is continued with intramuscular injections. In this case, 500–1000 mg per day is administered intramuscularly every 3 days for 4–6 weeks. The daily dose can also be administered at one time or divided into two.

For chronic heart failure Mildronate is administered intravenously at 500–1000 mg (5–10 ml of solution) once a day or intramuscularly at 500 mg (5 ml of solution) 2 times a day for 10–14 days. After completing the course of intravenous or intramuscular injections, they switch to taking Mildronate in the form of tablets or syrup for another 3 to 4 weeks.

In the acute period of cerebrovascular accidents Mildronate is administered intravenously at 500 mg (5 ml) once a day for 10 days. After this, the person is transferred to taking the drug in the form of tablets or syrup, or to intramuscular injections. Intramuscular injections are made at 500 mg (5 ml of solution) once a day for 2 - 3 weeks.

For chronic cerebrovascular accidents Mildronate can be taken in tablet form or administered intramuscularly. In such cases, the choice of method of administration of the drug (taking tablets or intramuscular injections) is determined by the person’s personal preferences, as well as his objective condition and the body’s ability to absorb drugs when taken orally. For example, if a person cannot swallow tablets, or they are poorly absorbed due to diseases of the digestive tract, then he should prefer intramuscular injections. If there are no obstacles to taking the pills, then it is better to choose this particular method of using the drug.

So, for chronic cerebrovascular accidents, it is necessary to administer 500 mg (5 ml of solution) Mildronate intramuscularly once a day for 2 to 3 weeks. The course of therapy can be repeated 2–3 times a year.

For pain in the heart due to dyshormonal myocardial dystrophy Mildronate is administered intravenously at 500–1000 mg (5–10 ml of solution) once a day, or intramuscularly at 500 mg (5 ml of solution) 2 times a day for 10–14 days. If the pain does not completely disappear after completing the course of Mildronate injections, the drug is prescribed in tablets for another 12 days.

For mental and physical overload or to speed up rehabilitation after surgery Mildronate can be administered intravenously, intramuscularly or taken in tablets. The choice of method of administration is based on the same criteria as for chronic cerebrovascular accidents. Mildronate is administered intravenously or intramuscularly at 500 mg (5 ml of solution) 1 - 2 times a day for 10 - 14 days. If necessary, the course of therapy is repeated after 2–3 weeks.

For chronic alcoholism Mildronate is administered intravenously for severe lesions nervous system. In this case, administer 500 mg (5 ml of solution) 2 times a day for 7 to 10 days.

In case of pathology of the fundus vessels or retinal dystrophy Mildronate is administered parabulbarly at 500 mg (5 ml solution) once a day for 10 days. In the presence of an inflammatory process in the eyes, Mildronate is combined with intravenous or also parabulbar administration of corticosteroid hormones (Prednisolone, Dexamethasone, Betamethasone, etc.). And for retinal dystrophy, it is rational to combine Mildronate with the use of drugs that improve microcirculation.

Special instructions

Mildronate tablets, syrup and injections are interchangeable methods of using the drug. This means that during one course of treatment you can switch from tablets, for example, to syrup or injections. Such transitions from any dosage form to another can be carried out within the same course of therapy.

People suffering from chronic liver and kidney diseases, with long-term use Mildronate should periodically monitor the functioning of these organs.

For myocardial infarction, Mildronate is not a first-line drug, the use of which is mandatory for the effective treatment of an acute condition.

Inclusion of Mildronate in the composition complex therapy for patients suffering from chronic heart failure, it increases their tolerance to physical and emotional stress.

During clinical trials It was found that Mildronate reduces the concentration of atherogenic lipid fractions ("bad cholesterol") in the blood.

Since there is no scientifically proven data on the safety of Mildronate for children, it is recommended to refrain from using this drug in children under 12 years of age.

Impact on the ability to operate machinery

Mildronate does not have a negative effect on the ability to control mechanisms, therefore, while using this drug, a person can engage in any type of activity.

Overdose

For capsules and syrup, no cases of overdose were detected during the entire period of use of the drug. At injection An overdose of Mildronate is possible and is manifested by the following symptoms:

• Decline blood pressure;
• Tachycardia (palpitations);
• General weakness.

Treatment of an overdose of Mildronate is only symptomatic, aimed at relieving painful manifestations and maintaining normal functioning vital organs.

Interaction with other drugs

Mildronate enhances the effects of cardiac glycosides (Strophanthin, Digoxin, Korglykon, etc.), beta-blockers (Propranolol, Metoprolol, Atenolol, Bisoprolol, etc.), as well as some blood pressure lowering agents.

Mildronate combines well with and improves the severity of the clinical effect of the following drugs:

• Antianginal agents (Sustak, Nitrong, Betalok, Cordanum, Trental, Dipyridamole, Riboxin, etc.);
• Anticoagulants (Warfarin, Thrombostop, etc.);
• Antiplatelet agents (Prostacyclin, Aspirin Cardio);
• Antiarrhythmic drugs (Adenokor, Amiodarone, Bretilate, Difenin, Cordarone, Moratsizin, Propanorm, Ritalmex, Rhythmiodarone, etc.);
• Diuretics (Veroshpiron, Diakarb, Furosemide, etc.);
• Bronchodilators (Ventolin, Berotek, etc.).

Mildronate should be combined with caution with Nitroglycerin, Nifedipine, alpha-blockers (Doxazosin, Setegis, Tulazin, etc.), antihypertensive drugs and peripheral vasodilators (Traklir, Naniprus, Cormagnesin, etc.), since there is a high risk of developing tachycardia Mildronate is contraindicated for use if a person has the following conditions or diseases:

• Increased intracranial pressure (due to impaired venous outflow or in the presence of intracranial tumors);
• Pregnancy and breastfeeding (due to lack of proof of complete safety);
• Increased sensitivity or allergic reactions on the components of tablets, syrup or solution;
• Age under 12 years.

Some instructions for use indicate that Mildronate is contraindicated for children under 18 years of age, however, such terms are reinsurance on the part of the drug manufacturer.

Meldonium - analogues

Analogues of Mildronate on the domestic pharmaceutical market are two groups of drugs - synonyms and actual analogues. Synonyms are drugs that contain meldonium as an active substance, just like Mildronate. Analogs are drugs that have similar therapeutic effects, but contain different active substances.

The following drugs are synonyms for Mildronate:

• Angiocardil solution for injection;
• Vasomag capsules and solution for injection;
• Idrinol injection solution;
• Cardionate capsules and solution for injection;
• Meldonium capsules and solution for injection;
• Midolate capsules;
• Mildracor solution for injection (only in Ukraine);
• Mildrocard capsules (only in Belarus);
• Melfor capsules;
• Medatern capsules.

The following drugs are analogues of Mildronate:

• Angiosil retard tablets;
• Antisten and Antisten MV tablets;
• Biosynth lyophilisate for the preparation of solution for injection;
• Bravadin tablets;
• Valeocor-Q10 tablets;
• Vero-Trimetazidine tablets;
• Histochrome solution for injection;
• Deprenorm MV tablets;
• Dibicor tablets;
• Dynaton solution for injection;
• Doppelhertz Cardiovital tablets;
• Ezaphosphine lyophilisate and ready solution;
• Inosie-F and Inosine-Eskom solution for injection;
• Carditrim tablets;
• Coraxan tablets;
• Coronatora pellets;
• Kudevita capsules;
• Kudesan drops;
• Medarum 20 and Medarum MV tablets;
• Mexicor capsules and solution for injection;
• Metagard tablets;
• Sodium adenosine triphosphate (ATP) solution for injection;
• Neoton lyophilisate for the preparation of solution for injection;
• Orocamag capsules;
• Pedea solution for injection;
• Predisin tablets;
• Preductal and Preductal MV tablets;
• Precard tablets;
• Ranexa tablets;
• Riboxin capsules, tablets and solution for injection;
• Rimecor and Rimecor MV tablets;
• Taufon tablets;
• Triducard tablets;
• Trimectal capsules;
• Trimectal MV tablets;
• Trimet tablets;
• Trimetazide tablets and capsules;
• Trimetazidine and Trimetazidine MB tablets;
• Trimitard MV tablets;
• Ubinon capsules;
• Firazir solution for injection;
• Phosphaden tablets and solution for injection;
• Ethoxydol tablets.

Mildronate - reviews

Almost all reviews about Mildronate are positive, due to the effectiveness of the drug in improving performance cardiovascular system. The entire set of positive reviews can be divided into two groups - those concerning the use of the drug for severe chronic diseases and the use of the drug for functional disorders or overload.

Thus, in positive reviews regarding the use of the drug for serious illnesses, people indicate that they have taken or periodically take Mildronate for vegetative-vascular dystonia, hypertension, heart failure or angina. With vegetative-vascular dystonia, Mildronate completely normalized the condition of a person for 3 to 5 months, who practically forgot about his disease for this period. When symptoms of dystonia reappear, people take a course of Mildronate and are satisfied with the result.

For hypertension, angina pectoris and heart failure, Mildronate is taken as part of complex therapy. In reviews, people who took Mildronate for these diseases noted that the drug relieves fatigue, eliminates shortness of breath, a feeling of weakness, hopelessness and apathy, reduces the frequency of angina attacks, increases the overall endurance of the body and the tolerance of physical and emotional stress.

People who took Mildronate for functional disorders of the cardiovascular system (for example, low blood pressure, heart pain due to stress or high loads, darkening before the eyes when moving from a sitting to a standing position, etc.) note in their reviews that that the drug quickly and completely eliminated their problem, instead of weakness and fatigue, lightness, energy, cheerfulness, clarity of mind and the desire to live appeared.

Many reviews note that Mildronate helped cope with high mental and physical stress, increasing performance and accelerating recovery after work. Athletes note that when using Mildronate it becomes much easier to breathe during aerobic training and endurance increases significantly.

Negative reviews about Mildronate are literally rare and they are usually associated with the development of a side effect that was poorly tolerated by a person and therefore forced them to stop using the drug.

Mildronate belongs to a class of drugs that can ensure normal metabolism in tissues, maintain energy balance and improve the body's metabolism. The active component of the drug is meldonium dihydrate, a synthetic substance that, in its principle of action, is very similar to gammabutyrobetaine. This drug can increase performance, relieve physical and mental fatigue, and activate immune functions. Has a protective effect for the cardiovascular system. The medicine is prescribed for the occurrence of heart failure, ischemic disorders, low performance, severe physical and emotional stress.

1. Pharmacological action

The active substance of the drug has a number of positive influences on the processes of blood flow and metabolism, by increasing the production of substances with a vasodilating effect. During the use of the drug, there is a positive dynamics of recovery after past diseases associated with circulatory disorders various localizations. There is also a pronounced restorative effect aimed at the affected areas due to the development of ischemia. In addition, Mildronate is able to eliminate disturbances in the central nervous system in patients suffering from withdrawal syndrome due to alcohol and drug addiction. The drug is absorbed quite quickly and is almost completely distributed over the affected areas, reaching its maximum concentration 2 hours after taking it. The drug is neutralized with the formation of breakdown products, which are subsequently excreted by the kidneys.

2. indications for use

• Phenomena of physical overstrain;
• Decreased performance;
• Hemorrhages in the membranes of the eye of various origins;
• Withdrawal syndrome in patients (as part of a drug complex);
• Withdrawal syndrome in patients suffering from drug addiction (as part of a drug complex);
• Various circulatory disorders of the retina;
• Retinal vascular thrombosis;
• Treatment of heart diseases associated with insufficient blood supply to the heart muscle (as part of a medicinal complex);
• Treatment of brain diseases associated with insufficient blood supply (as part of a drug complex).

3. Method of application

The dosage of the drug and the duration of treatment depend on the nature of the disease and the severity of the patient’s condition. Recommended dosage of Midronate for the treatment of diseases of the cardiovascular system:

• Persistent pain in the heart area (), as part of a drug complex: 250 mg of the drug three times a day for 4 days, then 250 mg of the drug three times a day no more than twice a week for one and a half months;
• Unstable painful sensations in the heart area () and impaired blood supply to the heart muscle (infarction): 0.5-1 g of the drug once on the first day of treatment (in the form of an intravenous jet infusion), then 250 mg of the drug in capsule form twice a day for 4 days. Next - 250 mg of the drug in capsule form three times a day, no more than twice a week for one and a half months.

Recommended dosage of Mildronate for the treatment of diseases of the central nervous system associated with insufficient blood supply: Acute disorders blood circulation of the brain: 0.5 g of the drug once a day for 10 days (in the form of an intravenous jet infusion), then 0.5-1 g of the drug per day (in the form of capsules) until positive dynamics of treatment occur (the duration of treatment is determined by the attending physician ). Recommended dosage of Mildronate for the treatment of vascular diseases of the eyes: Dystrophic phenomena in the retina or vascular diseases of the eyes: 50 mg of the drug per day (administered under the conjunctiva) for 10 days. Elimination of various conditions associated with overwork:

• Fatigue due to excessive physical or mental stress: 0.25 g of the drug in capsule form 3-4 times a day or 500 mg of the drug by intravenous jet method for 10-14 days. If necessary, the course of treatment can be repeated;
• Prevention of physical fatigue in athletes: 0.5-1 g of the drug twice a day for two to three weeks (before training) or for 10-14 days (during competitions).

Recommended dosage of Mildronate as part of a medicinal complex:

• Withdrawal syndrome in patients, or mild drug addiction: 0.5 g of the drug in capsule form four times a day or 0.5 g of the drug intravenously by bolus twice a day. The duration of treatment in both cases is 7-10 days;
• Treatment: 0.25 g of the drug once a day for 3 weeks.

4. Side effects

• Disorders of the nervous system (increased nervous excitability);
• Cardiovascular system disorders (heart rhythm disturbances, various changes in blood pressure);
• Digestive system disorders (digestive disorders);
• Various allergic reactions (peripheral edema, skin rashes, skin itching).

All of these conditions are extremely rare and disappear after lowering the dosage.

5. Contraindications

• Increased intracranial pressure;
• Individual intolerance to the drug or its components;
• Patients' age is less than 18 years;
• Pregnancy and lactation;
• Brain tumors;
• Disturbances of the venous outflow of the brain;
• Hypersensitivity to the drug or its components.

6. During pregnancy and lactation

Use of the drug at all stages of pregnancy not recommended, since there is not enough evidence of a negative effect on the body of the mother and child or its absence. The use of the drug during breastfeeding is necessarily accompanied by a complete cessation of breastfeeding for the entire duration of treatment until complete removal breakdown products from the mother's body.

7. Interaction with other drugs

• Simultaneous use with drugs intended for the treatment of persistent painful phenomena in the heart (angina pectoris) and some drugs whose therapeutic effect is associated with a decrease in blood pressure, an increase in therapeutic effect the latter;
• Simultaneous use with Nitroglycerin, drugs that block the alpha receptors of adrenaline, drugs that lower blood pressure, drugs that dilate peripheral blood vessels and Nifediline, a sharp decrease in blood pressure and heart rhythm disturbances are observed.

8. Overdose

The drug is low-toxic, as a result of which overdose phenomena have not been described to date.

9. Release form

Capsules, 250 or 500 mg - 40 or 60 pcs. Solution for injection, 500 mg/5 ml - amp. 10 pcs.

10. Storage conditions

Mildronate should be stored in a dry, dark place. Recommended temperature regime- no more than 25 degrees.

11. Composition

1 capsule:

• Meldonium dihydrate - 250 mg;
• Excipients: potato starch, colloidal silicon dioxide, calcium stearate.

1 ml solution:

• meldonium (trimethylhydrazinium propionate) - 100 mg;
• Excipients: water.

12. Conditions for dispensing from pharmacies

The drug is dispensed according to the prescription of the attending physician.

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* Instructions for medical use of the drug Mildronate are published in free translation. THERE ARE CONTRAINDICATIONS. BEFORE USE, YOU MUST CONSULT WITH A SPECIALIST

Mildronate is a common drug that normalizes metabolic processes and improves the energy supply of all organs at the cellular and tissue level. Due to its ability to stimulate metabolism and energy supply to cells and tissues, Mildronate is recommended for prevention purposes. various pathologies cardiovascular system, cerebrovascular accidents and other diseases.

The drug is also one of the most powerful doping agents known to every bodybuilder. Mildronate effectively increases endurance to increased loads in bodybuilding, allowing the athlete to train in the most intense mode.

Name, release form, composition

Mildronate is available in several pharmacological forms:

• Solution for intravenous, intramuscular injections, transparent, without a distinct odor. The solution is packaged in 5 ml ampoules and cardboard boxes. Each cardboard box contains 10 ampoules of the drug. 250 mg of active substance in each capsule;
• Capsules for oral administration, coated with a gelatin, enteric coating, with a white, crystalline powder inside;
• Tablets for internal use with traditional round shape with a dosage of 250 mg or 500 mg of the active ingredient.

The main active ingredient in the drug is meldonium, which is also known as mildronate or trimethylhydrazinium propionate dihydrate.

Capsule composition: meldonium, potato starch, calcium stearate, colloidal silicon dioxide, titanium dioxide and gelatin in the shell.

Composition of tablets: meldonium, povidone, potato starch, mannitol, microcrystalline cellulose, silicon dioxide, magnesium stearate.

Composition of the injection solution: meldonium and distilled water.

Therapeutic effect

Meldonium has a unique mechanism of action, which causes extremely wide range pharmacotherapeutic action of the drug.

• Cardioprotective effect – improves the condition of the cardiovascular system, reliably protects heart muscle cells, preventing the development of pathological conditions;
• Antihypoxic effect – promotes accelerated filling of cells and tissues internal organs oxygen, and also minimizes any manifestations of oxygen deficiency;
• Antianginal effect - provides myocardial cells with a unique opportunity to be saturated with a minimum amount of oxygen. As a result, a decrease in angina attacks, a decrease in the intensity of pain, and an increase in the body’s endurance;
• The angioprotective effect of Mildronate is to strengthen the walls of blood vessels, ensuring their integrity, effective prevention varicose veins.

The drug helps dilate blood vessels and improves the supply of oxygen to tissue cells, as a result of which they are saturated with energy. The result of using Mildronate is an increase in immunity, performance, and elimination of symptoms chronic fatigue and physical stress.

The drug actively functions in the presence of ischemia - penetrating into the cells of the retina of the eyeball, brain or heart, meldonium helps normalize blood circulation, thanks to which all cells and organ tissues receive vital nutrients and oxygen.

Mildronate is recommended for the treatment and prevention of many pathologies of the cardiovascular system. For example, when using a drug several hours after a heart attack, the process of necrosis of myocardial tissue is inhibited. In addition, the use medication significantly reduces the duration of the rehabilitation period after myocardial infarction.

Thanks to his therapeutic effect Meldonium is recommended for use in heart failure and coronary disease heart - the drug effectively reduces the frequency of angina attacks and increases the intensity of myocardial contractions.

One of the most important properties Mildronate is considered the ability to significantly increase the tolerance of strong physical exertion in bodybuilding, which thousands of bodybuilders were quick to take advantage of.

Indications for use

Mildronate has a wide range of uses. The drug is recommended for use in the following cases:

• As part of a comprehensive treatment of coronary heart disease;
• Numerous pathologies of the cardiovascular system - angina pectoris, chronic heart failure, myocardial infarction, myocardial dystrophy, accompanied by severe pain;
• Myocardial dystrophy and functional disorders in the work of the heart muscle in adolescents;
• Disorders of normal blood circulation in the brain, which can be both chronic and acute;
• Chronic bronchitis and bronchial asthma;
• Alcohol withdrawal, chronic alcoholism;
• Poor circulation, central vein thrombosis or retinal hemorrhage;
• Hypertensive and diabetic retinopathy;
• Decreased mental and physical performance, fatigue, physical stress;
• The drug is recommended for use during the rehabilitation period after surgery for accelerated recovery body.

Instructions for use

Mildronate is recommended to be taken orally, half an hour before or after meals. Tablets and capsules should be swallowed whole, without crushing or chewing. It is very important to remember that the drug increases performance, improves energy supply, and has an activating and stimulating effect on the body.

It is for this reason that it is best to use the product no later than 17-18 hours, otherwise problems with sleep may occur. If the drug is taken several times a day, you need to ensure that the last dose is before 18:00. At least 5 hours should pass from taking Mildronate to sleep.

The pharmacological form of the drug, the recommended dosage and duration of the course of administration are determined by the doctor and depend on factors such as the type of disease, severity, the presence of concomitant chronic diseases, and the person’s age. Most often, 500-750 mg of medication per day is prescribed, that is, 2-3 tablets or capsules.

But still, the optimal dosage of the drug is determined individually, since when various diseases Different doses of meldonium are recommended:

1. Stable angina - the recommended dosage is 250 mg of the drug three times a day. The duration of treatment is at least 3 days. After this, the medication is taken for the purpose of strengthening and supporting the body - 250 mg per day, but the drug is taken only once a day. This means that for each week of treatment there should be no more than 2 doses of Mildronate. The duration of the recovery program is usually at least 6 weeks.
2. Unstable angina, myocardial infarction - up to 1000 mg of the drug intravenously on the first day of treatment; on the second day it is recommended to start tablet therapy, taking 250 mg of the drug in the morning and evening. The duration of such treatment should not exceed 4 days, after which Mildronate is recommended to be taken according to the regimen described above - that is, 250 mg three times a day, once every three days. The duration of therapy in most cases is 4-5 weeks.
3. Dyshormonal myocardial dystrophy, accompanied by intense pain in the heart - the drug is recommended to be taken morning and evening, 250 mg, for 12-14 days. The duration of treatment is determined individually by the attending physician.
4. Late infarction period, characterized by acute insufficiency coronary circulation - you should take 1 tablet (250 mg) of Mildronate twice a day for 5-6 weeks. In some cases, the duration of treatment can be reduced to 3 weeks.
5. Acute circulatory disorders in the brain - the drug in the form of tablets or capsules is taken only on the 11th day of treatment, since for the first 10 days meldonium is administered to the patient intravenously. The recommended dosage is 500 mg (2 capsules or tablets) of the medication once, 1 time per day for 5-6 weeks.
6. Chronic cerebrovascular accident - the dosage is determined individually and can range from 250 to 750 mg of the drug per day.
7. Chronic bronchitis, bronchial asthma - doctors advise taking Mildronate 250 mg of the drug once a day for 2-3 weeks. In this case, meldonium acts not as an independent, but as an additional element in the complex treatment of bronchitis and bronchial asthma, combined with bronchodilators or anti-inflammatory medications.
8. Chronic alcoholism - Mildronate is one of the most effective medications used to treat even the most advanced stages of chronic alcoholism. Mildronate should be taken 4 times a day, 500 mg (2 tablets or capsules) for 8-10 days. It is imperative to remember that the last dose of medication should be taken before 17-18 hours.
9. Myocardial dystrophy or neurocirculatory dystonia in adolescents under 16 years of age - the required dosage of the drug is calculated individually, depending on the age and body weight of the teenager. On average, a dosage of 12-25 mg per 1 kg of body weight of a teenager is used. The daily dosage is divided into two doses throughout the day. The duration of treatment can vary from 3 to 5 weeks, in some cases treatment can be extended to 6 weeks.
10. The rehabilitation period after surgery, increased physical or intellectual stress, intense strength training in bodybuilding - in these cases, Mildronate is taken 1000 mg, dividing the daily dose into 4 doses throughout the day.

Mildronate injections - instructions

Mildronate solution is used for injections, which can be administered intramuscularly, intravenously or parabulbarly. Parabulbar administration means that with the help of a syringe with medicine an injection is made into the area under the eyeball, while with an intravenous injection the medicinal solution is injected directly into the venous cavity, and with an intramuscular injection into the soft muscle tissue.

It is important to remember that the ampoule with Mildronate solution must be opened immediately before the injection, but in no case beforehand. It is allowed to keep an open ampoule for no more than half an hour, after which the drug is strictly prohibited from being used - it is best to throw away the medicine and open a new ampoule.

The medicinal product must be completely clean, transparent and completely colorless, without unnecessary impurities. You need to carefully examine the ampoule with the solution - there should be no sediment or “flakes” in it. If there is sediment in the ampoule, the medicine cannot be used.

Mildronate injections are made similarly to other pharmacological forms of the drug - the last injection should be made before 18 o'clock if a person is used to going to bed late and before 16-17 o'clock if there is an early bedtime.

Dosages and rules of injection

The first thing you need to do is decide on the optimal method of administration. medicinal solution. If there is a need to achieve a clinical effect as quickly as possible (in acute conditions), intravenous injections are recommended.

For more long acting a medication with a gradual increase in clinical effect optimal choice will be intramuscular injections. In the treatment of many eye pathologies, parabulbar injections will be the most effective.

The recommended dosage for Mildronate injections is calculated by the treating specialist individually and depends entirely on clinical picture disease, its severity and the presence of other chronic diseases.

The most commonly used dosage is 500 ml of the drug per day for intravenous or intramuscular administration, 50 ml per day for parabulbar injections.

Application in bodybuilding

Meldonium found wide application in the field of strength sports - for example, in bodybuilding.

This drug effectively activates metabolism, improves the supply of oxygen and nutrients to the heart and other internal organs, increases performance and significantly increases the effectiveness of the bodybuilder’s training process.

Properties of Mildronate:

• Meldonium is an effective drug for normalizing energy metabolism at the cellular level against the background of ischemia or hypoxia;
• The drug perfectly restores the oxygen balance in the body against the background of increased physical or intellectual stress;
• The use of Mildronate in bodybuilding helps to increase the performance of the human body and restore energy reserves, as a result of which the body can withstand even the most intense power loads;
• Meldonium has a pronounced tonic effect on the cells of internal organs, promotes the accelerated removal of toxic decay products from cells, and accelerates their regeneration;
• Mildronate can not only significantly increase the performance of a bodybuilder, but also reduce the manifestations of physical and psycho-emotional fatigue;
• The drug promotes rapid recovery muscle fibers after an intense training process, both during strength and endurance loads.

It is thanks to their unique properties Mildronate has found wide use among many athletes and bodybuilders. However, starting from January 2016 Mildronate is officially recognized as a doping and is classified as prohibited. medicines. This decision was made by the World Anti-Doping Agency.

Dosage of the drug for athletes

Athletes are recommended to take 500-1000 mg of the drug, dividing the daily dose into 3-4 doses. Mildronate should be used according to an increasing scheme - in the initial stages you need to take 1 tablet of the medication immediately before the training process, gradually increasing the dose to 2-3 tablets.

Duration of treatment is 5-6 weeks, after which you need to take a break for 1-2 weeks. A pause in taking meldonium must be taken, since otherwise there is a high probability of developing resistance (addiction) of the body to the drug. And this can significantly reduce the effectiveness of Mildronate.

Athletes can use meldonium in any pharmacological form - tablets or injections. Tablets are considered more convenient to use, but less effective in bodybuilding. In turn, intravenous and intramuscular injections have an almost immediate effect, but this method The use of the drug is not very convenient.

Side effects

In most cases, Mildronate is well tolerated by the human body and does not cause side effects. In order to prevent possible side effects, it is recommended to take the drug strictly at a certain time. In this case, the last dose of the medication should be taken approximately 4-5 hours before bedtime.

Possible side effects of meldonium include:

• Increased heart rate;
• Psychomotor agitation, which may lead to confusion or sleep disturbances.

If side effects of Mildronate occur, it is recommended to change the method of using the drug - replace tablets with injections and vice versa.

Side effects of meldonium are extremely rare and in most cases are an individual reaction of the body to the active components that make up the drug.

Efficacy of Mildronate

Meldonium is recommended to be taken not only by professional athletes or bodybuilding enthusiasts, but also by people engaged in heavy physical labor. The fact is that with intense power load, even with careful adherence to sleep and rest, muscle fibers They just physically don’t have time to fully recover, but taking Mildronate helps muscle tissue recover at the most short terms.

Many people try to combine work with regular strength training and endurance exercises. In this case, the use of Mildronate will be the optimal solution necessary for rapid muscle recovery after several types of physical and intellectual stress.

The drug promotes not only the rapid restoration of cells, but also the removal of toxic substances and breakdown products from the body, as a result of which the process of regeneration of cells and tissues is significantly accelerated.

The main advantage of Mildronate in sports is that it significantly enhances the effectiveness of any sports training, since the drug perfectly relieves physical fatigue and eliminates fatigue, gives muscles lightness and energy, improves blood supply and nutrition of many internal organs and systems.

Mildronate for weight loss

Meldonium is the main active substance included in this drug and is an analogue of the so-called L-carnitine, used by many professional athletes for rapid weight loss.

But Mildronate should in no case be considered independent means for weight loss - it can only be used in combination with proper nutrition and regular exercise. Only in this case can we talk about its effectiveness in the process of losing weight.

The use of the drug helps reduce cholesterol levels, activate fatty and metabolic processes in the body. And this is an excellent basis for quick and effective weight loss. In order to get rid of it in the shortest possible time extra pounds, it is recommended to combine the use of Mildronate with intense physical activity - this combination will be the key to safe and intensive weight loss.

Drug overdose

Mildronate is a low-toxic drug that is well tolerated by the human body and very rarely causes side effects and pose virtually no harm to health. To date, cases of overdose with tablets or capsules Mildronate in medical practice not recorded.

In extremely rare cases, an overdose of a drug is possible when administered intravenously or intramuscularly.

Manifestations of overdose:

• Headache, turning into severe dizziness;
• Rapid heartbeat;
• Sharp fluctuations in blood pressure;
• Apathy, weakness;
• Allergic skin rashes - redness, itching, rash, swelling.

To eliminate unpleasant phenomena symptomatic therapy is used, aimed at eliminating the symptoms of intoxication of the body and restoring the normal functioning of its most important organs and structures.

Contraindications for use

Like any other drug, Mildronate has some contraindications, for which the use of the drug is strictly not recommended.

Such contraindications include:

• The drug should not be taken if there is an elevated intracranial pressure, developing against the background of pathology of venous outflow;
• Mildronate is not used if a person has intracranial tumors;
• The medication is contraindicated during all trimesters of pregnancy, as well as during breastfeeding. If there is a vital need for taking meldonium, lactation must be abandoned and the child must be switched to artificial nutrition;
• The medicine is allowed to be taken only by children over 12 years of age. The drug is strictly prohibited for children under 12 years of age;
• A contraindication to the use of Mildronate is considered increased sensitivity or individual intolerance one of the active components included in the medicinal product.

Mildronate: tablets, ampoules – price

The cost of the drug directly depends on the pharmacological form of release and dosage. In many pharmacy chains, the cost of the drug differs, but on average it ranges from 240 to 290 rubles for tablets with a dosage of 250 mg. The price of tablets with a dosage of 500 mg of the active ingredient is slightly higher and ranges from 510 to 640 rubles.

The cost of Mildronate capsules is significantly higher than tablets, and depending on the pharmacy chain, it can be sold at a price of 570-680 rubles. Meldonium in the form of a solution for intravenous, intramuscular or parabulbar injections can be purchased at a price of 340-400 rubles per pack of ampoules.

Analogues

Analogues of Mildronate include drugs in which the main active substance is meldonium and which have a similar effect on the human body.

These analogues of tablets and capsules include:

Analogues of Mildronate ampoules include such injection solutions as Biosint Lyophysilate, Histochrome, Dynaton, Inosin-Eskom, Neoton, Riboxin, Firazyr.

MILDRONATE ® (Mildronate ®) - composition and instructions for use, minimum cost, photo of packaging, drug analogues, side effects and contraindications. MILDRONATE ® (tablets, injections, capsules) is a metabolic drug that is synthetic analogue gamma-butyrobetaine, a substance that is found in every cell of the human body. Before taking the drug, it is logical to find out why Mildronate is prescribed. Doctors' instructions for Mildronate and reviews of taking this drug are of quite great interest to the general public.

Mildronate (meldonium, cardinate) is a drug that improves metabolism and energy supply to tissues, available by prescription. The drug was created in the 70s of the XX century at the Institute organic synthesis Latvian SSR, developed by Professor Ivars Kalvins. The compound was originally patented as a means to control plant growth and promote the growth of animals and poultry.

Mildronate ® (Mildronate ®) - Instructions for use

WADA considers Mildronate as a metabolic modulator similar to insulin. A study published in December 2015 in the journal Drug Testing and Analysis claims that meldonium improves athletes' performance, endurance, improves recovery after performance, protects against stress and increases the functional activity of the central nervous system.

Since January 1, 2016, meldonium has been added to class S4 (Hormones and metabolic modulators) of the prohibited list and is prohibited for use in and out of competition. The drug received wide publicity due to a number of sports scandals, as it was equated to doping. However, if its use in a sports environment is limited, then ordinary people can resort to this remedy, however, only when prescribed by the attending physician.

Mildronate - the instructions for use of which describe the indications and dosage, are produced by the manufacturer in three forms: gelatin capsule, ampoules with the injection drug dissolved in water, tablets.

It has a whole range of pharmacological effects: antianginal (directed against angina attacks), cardioprotective, antihypoxic (increasing resistance to oxygen starvation) and angioprotective (beneficially affecting vascular wall and microcirculation).

Its effectiveness has been confirmed according to all the rules evidence-based medicine within the framework of two double-blind randomized clinical trials conducted in Riga and Tomsk. And it is unlikely that mildronate would have managed to gain such popularity among domestic specialists, patients and even athletes if it were a useless “dummy”.

Why and who needs mildronate-meldonium: report

There is a misconception among non-professionals that taking Mildronate can provoke an increase in muscle mass. The opinion is completely wrong; this medication has no effect on muscle volume. Athletes take Mildronate only as a means to restore strength, strengthen the body and increase resistance to stress.

Mildronate: tablets, injections - instructions for use

But the statement that Mildronate helps tissues regenerate is absolutely correct. Indeed, when taking this drug, cells are restored faster, as the flow of oxygen to the tissues is activated. Metabolism also becomes more active. Mildronate is available for sale in the form of ampoules, tablets and capsules. The ampoules contain a special liquid that is completely ready for use.

Against the background of increased load, the drug balances the processes of oxygen delivery to cells and its consumption at the destination, prevents the accumulation of toxic breakdown products in cells, protecting them from damage, has a tonic effect and mildronate - the instructions for use confirm this.

Thanks to mildronate, the body is endowed with the ability to withstand increased loads and restore your energy reserves faster. In this regard, mildronate is used in the treatment of various cardiovascular pathologies, cerebrovascular accidents, and increasing mental and physical performance.

The vasodilating properties of mildronate are due to its ability to reduce the concentration of carnitine while increasing the synthesis of gamma-butyrobetaine.

1. In case of heart failure, mildronate helps the myocardium to contract better and withstand physical activity;
2. In ophthalmology, mildronate is used in cases of vascular and dystrophic pathology of the fundus;
3. At acute ischemia cardiac muscle, the drug slows down the necrotic degeneration of myocytes, accelerates the rehabilitation process;
4. In acute and chronic cerebral ischemia, the drug improves cerebral circulation and optimizes microcirculation in favor of the tissue area most affected by ischemia.

Due to its ability to eliminate functional disorders of the central nervous system in persons suffering from alcoholism, the drug is effective in treating withdrawal symptoms. This drug goes well with the following medications:

• Diuretics (Diacarb, Veroshpiron);
• Bronchodilators (Berotec, Ventolin);
• Antiplatelet agents (Aspirin Cardio, Prostacyclin);
• Antiarrhythmic drugs (Ritalmex, Difenin, Cordarone);
• Antianginal drugs (Riboxin, Sustak, Trendal).

In some cases, Mildronate - instructions for use enhances the effect of other drugs. This occurs when taking this drug simultaneously with the following medications:

• Cardiac glycosides (Digoxin, Strophanthin);
• Beta-adrenoblockers (Metaprolol, Atenolol, Propranolol);
• Medicines that lower blood pressure.

Release form and composition

• Active ingredient: Meldonium;
• ATX code: C01EV;
• Manufacturer: JSC “Grindeks”, Latvia;
• Latin name: Mildronate.

One hard gelatin capsule of Mildronate contains 250 or 500 mg. Meldonium in the form of dihydrate as an active component and excipients: Amylum solani (potato starch), Silicii dioxydum colloidale (colloidal silicon dioxide), Calcium stearate (calcium stearate). Gelatinum (gelatin) and Titanium dioxyde (titanium dioxide) are used to make the gelatin shell.

In 1 ml. Mildronate injection solution contains 100 mg. Meldonium and water for injection as an auxiliary component. 1 tablet Mildronate contains 500 mg. Meldonium in the form of phosphate and auxiliary components: Mannitum (E421; mannitol), Povidonum K-29/32 (povidone K-29/32), Amylum solani (potato starch), Silicii dioxydum (silicon dioxide), Cellulose microcrystalline (microcrystalline cellulose), Magnesium stearate (magnesium stearate) .

The drug Mildronate is produced by the manufacturer in the form:

• Mildronate Gx 500 mg tablets. (the taste of the tablet is slightly sour);
• Transparent colorless solution for injection;
• Hard gelatin capsules No. 1 and No. 2, filled with hygroscopic white crystalline powder. The powder contained in the capsules has a weak characteristic odor and a sweetish taste (the capsule itself has a neutral taste).

Capsules are packaged in blisters of 10 pieces each. One cardboard box contains 4 blisters and instructions for use of the drug. The solution is sold in 5 ml ampoules. (500 mg/5 ml). One cardboard package contains: 2 blister packs with 5 ampoules of Mildronate in each and instructions for use of the drug.

Mildronate - instructions for use

When choosing Mildronate in tablet form, you need to remember: the drug is swallowed whole, it cannot be chewed. The same applies to capsules. Tablets should be stored in their original packaging in a place protected from light, away from children. Usually capsules and tablets are recommended to be taken if Mildronate is prescribed as an element of complex therapy against cardiovascular pathologies.

Mildronate - instructions for use and what it is needed for

You can often come across questions “ Is it possible to administer Mildronate intramuscularly?" or " Is it possible to inject the drug intramuscularly?". The instructions for medical use indicate that the drug in injection form is intended for intravenous administration, it should be administered separately from other drugs, diluted aqueous solution sodium chloride is not required (however, in some cases it is allowed), and capsules and tablets are intended for oral administration (per os).

The manufacturer recommends taking no more than 1 g of Mildronate per day. Mildronate is usually used twice a day. The duration of the course is 30 days, but sometimes a longer duration is required. When injected into a muscle, the injection solution is irritating and can cause local pain and allergic reactions. local character. For this reason, the drug Mildronate is usually injected into a vein.

The dose and route of administration of Mildronate depend on the disease:

1. Athletes are recommended to take 500 mg-1 g 2 times a day before training. The duration of the course in the preparatory training period is 14-21 days, during the competition period - 10-14 days;
2. For reduced performance, mental and physical stress (including athletes), 500 mg is prescribed orally. 2 times/day. The course of treatment is 10-14 days. If necessary, therapy is repeated after 2-3 weeks;
3. For chronic cerebrovascular accidents, take 1-2 tablets of Mildronate (500 mg each) per day for a course of 4 to 6 weeks. In some cases, the doctor recommends taking a second course, but no more than three in a year;
4. For disorders caused by chronic alcoholism, usually take 1 tablet of Mildronate (500 mg) 4 times a day for 10 days;
5. In the acute phase of cerebrovascular accident, Mildronate is administered intravenously for 10 days at a dose of 500 mg according to the instructions. once a day. After this, you can switch to taking Mildronate tablets, 0.5-1 g per day. The general course of use is up to 6 weeks;
6. After a heart attack, 500-1000 mg is administered intravenously on the first day. solution. Then the patient is transferred to tablets. They should be taken 2 times a day, 250 mg. Next, you need to take the drug three times a day (the dosage is the same), but this should be done twice a week. The duration of therapy is 4-5 weeks;
7. Bronchial asthma - the drug is used in complex therapy with bronchodilators. It is prescribed once a day for 3 weeks;
8. Asthenic syndrome - it is recommended to take 5 ml syrup. 5 times a day. The duration of therapy is 14 days;
9. For cardialgia developing against the background of dishormonal myocardial dystrophy, Mildronate - instructions for use advises taking 250 mg twice a day for 12 days;
10. Stable angina – 1 tablet 250 mg. or 5 ml. syrup three times a day. You need to take this regimen for 3-4 days. After this, the dosage and number of doses remain the same, but you should take the drug only 2 times a week. The duration of therapy varies from 1 to 1.5 months;
11. Unstable angina and myocardial infarction. 0.5-1 g intravenously once a day, after which the patient is prescribed the drug orally at 0.25 g 2 times a day for the first 3-4 days, then twice a week at 0.25 g 3 times a day;
12. For increased mental or physical stress, take 1 tablet of Mildronate 250 mg, up to 4 times a day for two weeks. A repeat course can be taken no earlier than 2 weeks;
13. At cordially- vascular diseases Mildronate is indicated as part of complex therapy, up to 2 times a day, 0.5-1 g. Treatment is usually carried out from a month to 6 weeks;
14. Patients with acute heart failure are additionally prescribed fast-acting cardiac glycosides (strophanthin, corglycon, celanide) and diuretics;
15. Acute phase of cerebrovascular pathology. 5 ml. A 10% solution once a day intravenously for 10 days, after which the drug is prescribed to the patient orally at 0.5 g per day. The course of treatment is 2-3 weeks.

Mildronate is indicated for use in the first half of the day and no later than 17:00 when taken several times a day due to the possibility of developing an stimulating effect. Adults: 15 to 20 mg. per kg. weights 1 time per day, preferably 30 minutes before training.

Mildronate tablets: instructions for use and dosage

Mildronate tablets have a wide range of applications. The drug is effective in treating many diseases. The instructions for the drug indicate that the drug is available both in the form of an injection solution and in the form of tablets for oral administration.

The tablets must be taken whole and should not be chewed or crushed. It is forbidden to spill Mildronate tablets from the capsule. Indications for use in diseases of the heart and blood vessels - the medicine is prescribed in the form of tablets and capsules. Recommended daily dose does not exceed 1000 mg. You can divide the required dose of the drug into 2 applications. Therapeutic treatment with Mildronate in tablet form lasts on average about 30 days.

Indications for use of Mildronate: what are Mildronate tablets for?

This medicine can be used for cardialgia, which is a consequence of hormonal disorders. In this case, it is necessary to use the drug once a day if the dosage of the drug is 500 mg. If the tablets have a dosage of 250 mg, then you need to take the drug 2 times a day.

In that situation when acute pathologies cerebral circulation have been eliminated, the patient is prescribed Mildronate in a daily dosage of 500-1000 mg. They drink the medicine either once a day, or divide the daily dose into several doses.

For patients with chronic changes in the blood supply to the brain, it is recommended to use the drug in an amount of 500 mg. per day. The duration of course therapy is on average 40 days. The treating doctor may prescribe the patient a second course of treatment. It is carried out no more than 3 times a year.

For patients suffering from arterial diseases, Mildronate - instructions for use recommends prescribing it twice a day. For increased mental and physical stress, the drug is usually prescribed in a dosage of 1000 mg. The daily dose must be divided into several doses. The duration of treatment with Mildronate is on average three weeks. After the three-week period, the course can be repeated again.

Athletes can use the drug before sports training. The course of treatment in preparation for competitions lasts two weeks. During competitions, it can be used for no more than 15 days.

Mildronate injections: instructions for use

Injections are given intravenously, parabulbarly or intramuscularly. In the first option, the drug is injected into a vein, so it immediately enters the blood. At intramuscular injections the solution enters the thickness of the muscles, and then spreads evenly to the cells.

Mildronate injections: instructions for use

Parabulbar injections involve the injection of the drug into the eye tissue. Treatment solution Available in ampoules with a capacity of 100 ml. They should be opened immediately before Mildronate injections are given. If the ampoule with the solution was opened in advance, it cannot be used: such a drug must be thrown away.

Before opening the medicinal product, the solution must be carefully inspected. You should make sure that there is no sediment or flakes in it. If they are present, the drug cannot be used for treatment. Only a clean, transparent solution can be used for injection.

Intramuscular injections can be done at home, but intravenous and parabulbar injections can be done in a hospital. They must be performed by a qualified nurse.

Medicinal product Mildronate - instructions for use, indications for injections:

Mildronate - instructions for use for injections is supplied completely ready for use. This drug is administered intravenously separately from the others. medical supplies. Mildronate does not need to be diluted with sodium solution.

When the solution is administered intramuscularly, the injection agent often provokes pain. An allergic reaction may develop and skin irritation may occur. Therefore, Mildronate is most often injected directly into a vein. Mildronate injections can be used for progressive angina, heart attack, vascular diseases of the fundus and cerebrovascular accidents.

• Patients with vascular pathologies fundus, the medicine is administered retrobulbarly (behind the eyeball) or subconjunctivally (under the outer shell of the eyeball) 0.5 ml. for 10 days;
• Patients with cerebral circulatory disorders in chronic form shown intramuscular injection Mildronate 1-3 times a day at a dose of 500 mg. (optimally - before lunch). The duration of the therapeutic course is from 2 to 3 weeks;
• For patients with coronary syndrome, the drug is injected into a vein in a dose of 500-1000 mg. 1 time per day. After this, therapy is continued by taking tablets or capsules;
• Patients with cerebral circulatory disorders in acute stage the solution is injected into a vein once a day at a dose of 500 mg. The duration of the therapeutic course is 10 days. Further treatment is carried out using oral dosage forms;
• At coronary syndrome This drug is administered intravenously. The drug is used 1 time per day. Mildronate is administered in a uniform stream, the recommended dosage is no more than 1000 mg. After treatment with injections, Mildronate therapy should be continued. The patient takes the drug in the form of capsules or tablets;
• If the blood supply to brain cells is impaired in patients with acute form diseases, the solution must be administered intravenously. Use Mildronate - instructions for use 1 time per day. The dosage of the drug is 500 mg. Further therapy is carried out using tablets;
• If the patient suffers from chronic cerebrovascular accident, Mildronate should be administered intramuscularly. The drug is used on average twice a day at a dosage of 500 mg. It is best to use the medicine in the first half of the day. Duration drug therapy is usually 3 weeks;
• If the patient has vascular changes in the fundus of the eye, the drug should be administered behind the eyeball area. The duration of treatment is at least ten days. In this case, the drug is used in a dosage of 0.5 ml.

Mildronate: what is it prescribed for and what do tablets and injections help with?

In what cases is Mildronate prescribed and why?

1. After using Mildronate, you can withstand more stress on the body and recover quickly. Thanks to these properties, the drug is used to improve blood supply to the brain and treat various disorders of the cardiovascular system, as well as improve performance;
2. In case of ischemic disorders of cerebral circulation, Mildronate is used to improve blood circulation in the area of ​​ischemia, which promotes blood redistribution;
3. The active ingredient Mildronate improves metabolism, promotes the removal of accumulated toxins from cells, has a tonic effect and protects cells from damage;
4. In case of heart failure, Mildronate according to the instructions increases myocardial contractility, reduces the frequency of angina attacks, while increasing tolerance to physical activity;
5. Also, according to reviews, Mildronate is effective for disorders of the nervous system with withdrawal syndrome and fundus pathology;
6. Meldonium helps reduce the concentration of free carnitine, prevents the transport of long-chain fatty acids through cell membranes, prevents the accumulation in cells of activated forms of unoxidized fatty acids, which are derivatives of acylcarnitine and acyl coenzyme;
7. In ischemic tissues, it restores the balance between the transport of oxygen and its absorption by cells, prevents disruption of the transport of adenosine triphosphate, while simultaneously activating glycolysis, which occurs without additional oxygen consumption. The result of a decrease in carnitine concentration is increased synthesis of the vasodilator γ-butyrobetaine;
8. The action of the active substance of the drug is aimed at inhibiting the enzymatic activity of γ-butyrobetaine hydroxylase, which is the last enzyme in chain reaction synthesis of L-Carnitine;
9. After taking Mildronate tablets per os - instructions for use, the meldonium contained in it is quickly absorbed into the digestive tract. The drug is characterized by a fairly high bioavailability index. The latter is approximately 78%;
10. The concentration of Meldonium in the blood plasma reaches its maximum values ​​an hour or two after administration. In the body, meldonium is metabolized to non-toxic products - glucose, succinate, 3-hydroxypropionic acid;
11. Metabolites are excreted by the kidneys. The half-life (T½), depending on the characteristics of the particular organism and the dose taken, can range from 3 to 6 hours;
12. The drug in injection form is characterized by 100% bioavailability. The concentration of Meldonium in the blood plasma reaches its maximum values ​​immediately after administration of the drug;
13. The result of Meldonium metabolization is the formation of non-toxic metabolites (glucose, succinate, 3-hydroxypropionic acid), which are then excreted from the body by the kidneys.

Side effects after using the drug

Side effects caused by taking Mildronate occur quite often. Typically they are expressed as:

• Changes in blood pressure;
• Tachycardia;
• Psychomotor overexcitation;
• General weakness;
• Belching, flatulence and other symptoms of dyspepsia;
• Increased arousal;
• Dyspeptic symptoms, manifested by belching, attacks of nausea, vomiting, heartburn, a feeling of fullness in the stomach even after a small portion of food;
• A rapid increase in eosinophils in the blood;
• Mildronate - instructions for use according to reviews can also cause allergic reactions in the form of swelling, rash, redness or itching.

In case of poor tolerability, you should immediately notify your doctor to adjust the chosen course or replace the drug.

Caution should be exercised when used simultaneously with certain antianginal and antihypertensive drugs, as well as cardiac glycosides, since Mildronate enhances their effect. When used simultaneously with Mildronate, antihypertensive drugs, nifedipine, nitroglycerin, peripheral vasodilators and alpha-blockers may develop moderate tachycardia and arterial hypotension.

Mildronate can be taken with anticoagulants and antiplatelet agents, as well as diuretics and antiarrhythmics. The safety of Mildronate is confirmed by periodically updated safety reports and the results of published clinical studies.

After Latvia joined the European Union, it became a mandatory requirement of regulatory authorities to have a Pharmacovigilance system responsible for monitoring and evaluating the use of medicines.

Since the beginning of monitoring (since March 21, 2006), Grindeks JSC has received 478 spontaneous reports (messages) about products containing meldonium. There have been no reports of the development of dependence or addiction to the drug after its use. There were no reports of adverse events or reactions from athletes.

Indications for use of Mildronate

Indications for use of Mildronate (for all dosage forms of the drug):

• Reduced performance;
• Physical overload (including in sports);
• COPD;
• Heart disease, including ischemic;
• Hemorrhage into the cavity vitreous eyes (hemophthalmos);
• Peripheral artery disease;
• IHD (in combination with other drugs and treatment methods);
• Cardialgia (pain in the left side chest), caused by dishormonal myocardiopathy;
• Stroke;
• Thrombosis and occlusion of the central retinal vein or its branches;
• Discirculatory encephalopathy;
• Postoperative period (to speed up the recovery of the body);
• Respiratory tract diseases;
• Bronchial asthma;
• Hemorrhage into the retina of the eye;
• Mental disorders caused by drinking alcoholic beverages.

The absolute safety of Mildronate in the treatment of pregnant women has not yet been proven. In order to prevent the negative impact of the drug on the full and healthy development of the fetus, you should not use Mildronate during pregnancy. We found out what the remedy helps with, but you should still refrain from such treatment during pregnancy.

The medication Mildronate - instructions for use recommends using it during physical overexertion, decreased performance, and during recovery in the postoperative period.

It is also unknown whether meldonium is present in breast milk women. Therefore, when treating with Mildronate, doctors advise stopping breast-feeding for women. Mildronate interacts freely with various drugs and does not conflict with them.

Mildronate is often used for sleep disorders. Why is the remedy prescribed in such cases? To combat insomnia or overly vivid, aggressive dreams, dizziness, noise in the ears and head, and frequent fainting.

Mildronate - instructions for use has the ability to increase a person’s endurance, so after using the drug, physical and intellectual stress is tolerated much easier. Mildronate is often used by athletes. After all, it improves the nutrition of the heart, helps reduce fatigue, and therefore increases the intensity physical training. Mildronate promotes rapid restoration of body cells and faster metabolism.

Contraindications

According to the instructions for use, Mildronate is contraindicated for use in childhood up to 18 years of age, with hypersensitivity to the drug.

Mildronate tablets and injections - instructions for use advise not to take in case of: intracranial tumors, impaired venous outflow, individual non-acceptance of the drug, which can cause an allergy.

Reliable studies on the use of Mildronate during pregnancy and lactation have not been conducted, as a result of which the drug is not recommended for use during these periods. With caution: with liver and/or kidney diseases.

The instructions remind you that you cannot combine the use of medication and alcohol, especially if it is used to treat cardiovascular diseases. The drug is sold in pharmacies only with a prescription from the attending physician.

Price for Mildronate in pharmacies, how much the drug costs

The price of the medicine depends on the form of release. Average price packs of capsules of 250 mg. – from 250 to 300 rubles, tablets of 500 mg. – from 559 to 655 rubles, injections for intravenous administration – 320-380 rubles, Mildronate Gx 500 mg. - 715-720 rubles.

• Mildronate capsules 250 mg. No. 40 (Latvia) 297.00 rub.;
• Mildronate capsules 500 mg. No. 60 (Latvia) 646.00 rub.;
• Mildronate injections/ampoules 10% 5 ml. No. 10 (Lithuania) 401.00 rub.;
• Mildronate injections/ampoules 10% 5 ml. No. 20 (Lithuania) 751.00 rub.

Mildronate: cheap analogues and substitutes

Complete analogues for the active substance:

• Midolat;
• Meldonium dihydrate;
• Idrinol;
• Medatern;
• Melfort;
• Meldonium-Eskom;
• Meldonium;
• Vasomag;
• Trimethylhydrazinium propionate dihydrate;
• 3-(2,2,2-Trimethylhydrazinium)propionate dihydrate;
• Cardionate.

In pharmacies, prices for capsules start at 300 rubles for 40 tablets of 250 mg. For 10 injections of Mildronate 10% in ampoules of 5 ml. you need to pay 400 rubles.

Use of Mildronate during pregnancy and lactation

Mildronate - instructions for use prohibit use during pregnancy. This is due to the fact that the safety of the drug could not be fully proven. The components included in the composition penetrate the placental barrier, therefore, when using the drug, breastfeeding the baby must be stopped.

It has not been established whether meldonium can be excreted in the milk of a nursing woman. Therefore, if treatment with Mildronate is indicated for the mother, she must stop breastfeeding for the entire period of therapy.

Mildronate and alcohol: compatibility, can they be taken together?

Like some analogues, Mildronate (reviews and instructions confirm this) shows good results in the treatment of people suffering from addiction to alcoholic beverages.

In case of pronounced withdrawal syndrome, Mildronate is used 4 times a day. The maximum daily dose is doubled compared to other situations: it reaches 2 g. The duration of the course is one and a half weeks.

At alcohol addiction and severe intoxication of the body, Mildronate can be used in the form of injections. On sale the drug is presented prepared for use. When administered into the body, Mildronate and other drugs should not be mixed. It is not recommended to use sodium solution to dilute the medication.

Administration into a vein is often recommended for coronary diseases, and the drug is administered once a day in an amount of up to 1 g. The active substance of Mildronate is excreted from the body within 12 hours, therefore, after this time, the risk of interaction of the drug with another active substance is extremely low or completely absent .

Generally, Drinking alcohol during treatment with Mildronate is not prohibited. However, if this drug is used to treat a cardiovascular disease or a cerebral circulatory disorder, the patient is still advised to stop drinking alcohol.

The poor compatibility of Mildronate with alcohol is due to an increased risk of various types of complications and the likelihood of a relapse of the disease. For patients with alcohol withdrawal caused by constant consumption of alcohol in large quantities, the drug should be used 4 times a day. The recommended dosage should not exceed 2000 mg. Duration therapeutic treatment averages one and a half weeks.

Cardionate or Mildronate - which is better?

Cardionate and Mildronate are synonymous drugs. They are based on the same active ingredient, so both products have a similar mechanism of action. The only difference is that, unlike Mildronate, Cardionate is available only in the form of 250 mg capsules. and solution for injection 500 mg/5 ml.

The use of mildronate during sports: features of use

Mildronate - instructions for use is widely known among professional athletes for its properties of helping the body recover after intense training. Meldonium helps oxygenate cells in need and removes breakdown products. In addition, it energetically nourishes cells. When an athlete recovers faster, he starts the next workout earlier, and then his productivity increases.

Indications for the use of the drug for athletes exist when he has a period of intense and frequent training, and he does not have time to recover between them. The instructions for use are as follows: capsules or tablets should contain up to 1 g of the substance per day in a total dosage, take them 30 minutes before training.

Intravenous injections are more effective; the daily dose for an athlete is 5-10 ml. The course of treatment should last no longer than six weeks. The drug is not addictive. It should be remembered that taking medication by injection or orally, capsules, tablets, will not replace the athlete good nutrition, rich in carbohydrates and proteins.

If you are on a very limited diet, take Mildronate - the instructions for use of which state that it is pointless, since it will not affect the exhausted body. The ability of a drug to interfere fatty acids getting into the cells of the body helps to achieve the effect of losing weight during intense exercise.

Features of use:

• Reduces fatigue;
• Under conditions of ischemia, it restores the balance of the processes of oxygen delivery and its consumption in cells, prevents disruption of ATP transport;
• Improves muscle nutrition;
• Prevents the accumulation of activated forms of unoxidized fatty acids in cells;
• Protects the heart and increases myocardial contractility;
• Increases the effectiveness of training;
• Activates glycolysis, which occurs without additional oxygen consumption.

Mildronate prevents fatty acids from penetrating into the cells and thus prevents the accumulation of fats in the liver. In addition, by burning predominantly sugars, the body spends a larger amount of raw materials, which are fats, for each molecule of adenosine triphosphate produced (that is, for energy production).

Mexidol and Mildronate (meldonium) - video review

Meldonium was not classified as a doping drug until January 1, 2016, which made it possible to use it absolutely legally in all sports. However, after the introduction of a ban on the use of the drug by the World Anti-Doping Agency (WADA) at the beginning of 2016, a number of athletes, mainly from Russia and the former CIS countries, were caught using this drug. Mildronate also became the subject of a huge scandal when Maria Sharapova admitted using this doping on March 7, 2016.