When a runny nose occurs, many of us approach this problem differently. Some snot cannot be treated and they think it will go away on its own, while others, on the contrary, drip everything into the nose.

Such approaches to the treatment of runny nose are fraught with allergic reactions, the occurrence of prolonged inflammatory processes, drying of the nasal mucosa. In treatment, as in life, there should be moderation in everything. Therefore, it is better to determine the right medication in the otolaryngologist’s office. On pharmaceutical market There is a drug called dioxidin, which doctors use to treat complicated runny nose.

Important! Every patient should know that dioxidin is not used for the following types runny nose:

• allergic;
• vasomotor;
• medicinal;
• viral;
• atrophic and hypertrophic;
• traumatic.

Effect of dioxidin and indications for use

• purulent wounds Oh various localizations;
• burns with an infected wound surface;
• phlegmon;
• pleurisy of purulent origin;
• trophic ulcers;
• peritonitis;
• others purulent processes.

Dioxidin is an antibacterial agent that destroys a wide range of pathogenic microflora. It also affects pyogenic microbes. Dioxidin often exhibits high efficiency in cases where others antibacterial agents turned out to be powerless.

Therefore, the drug is prescribed only in cases of pronounced purulent process and severe forms infection. Dioxidin successfully suppresses staphylococcus, anaerobes, Klebsiella, salmonella, streptococcal pathogens, Pseudomonas aeruginosa and other infections.

Despite the absence of indications for the treatment of runny nose in the instructions for the drug, ENT departments successfully use dioxidin in their work. Now, let's take a closer look at how dioxidin is used in practice to treat a runny nose.

As a result of the accumulated experience in using dioxidine, we present to your attention detailed guide on the use of dioxidine for a prolonged runny nose.

What form of the drug can be used for nasal instillation?

At the pharmacy you can buy ampoules with 0.5 or 1% dioxidine solution. One ampoule contains 10 ml medicinal solution. For each instillation, the solution must be fresh; it is not recommended to store open ampoules, but in practice, an ampoule is more often used during the day (enough for three instillations: morning, afternoon and evening). The ampoule must be stored in the refrigerator, after covering the open neck with a cotton swab.

Important! Ampoules with a 0.5% solution do not need to be diluted before intranasal (through the nose) administration, but a 1% solution should be diluted in a 1:1 ratio with saline or distilled water.

How to use dioxidin correctly?

Usually the drug is used externally, intravenously or injected into the lesion cavity. For treatment persistent runny nose dioxidine is instilled into the nasal passages. When treating sinusitis, the drug is administered intracavitarily.

The ampoule with the solution is opened and the required dose of the drug is drawn into the pipette. The average dose for adults is 2-3 drops in each nostril three times a day; for children, 1-2 drops 2-3 times a day are enough. According to indications, the doctor prescribes required amount drug in each individual case of treatment of prolonged rhinitis or sinusitis.

For better action of the drug, the nasal passages are first washed with saline solutions: Aquamaris, Quix, Marimer and others. Saline solution is easy to prepare at home: per glass boiled water room temperature, you need to take 3-5 grams of food or sea ​​salt. Stir the contents thoroughly so that the salt crystals all dissolve. Then inject about 1 ml of solution into each nostril.

After rinsing, blow your nose, and after 3-5 minutes, drip the dioxidine solution. The course of treatment with dioxidine depends on the severity of the infectious process, but does not exceed a week.

Dioxidin shows high effectiveness in purulent processes, and the symptoms of the disease usually disappear within 3-4 days after the start of the medication. The drug is so powerful that all pathogenic flora die with lightning speed.

Is there any harm from using dioxidin?

Dioxidin exhibits toxic activity and cannot be used for a long time. It has contraindications in the following cases:

• pregnancy (due to teratogenic effects on the fetus),
• breastfeeding;
• individual intolerance;
• severe diseases of the kidneys and adrenal glands.

When using dioxidin, side effects may also appear, such as:

• hyperthermia (increased body temperature);
• allergy;
• dark spots;
• chills;
• stool disorder;
• headache;
• convulsive muscle twitching;
• dermatitis (in cases of using dioxidine externally).

Such side effects appear with intracavitary and intravenous administration of the drug. To relieve them, antihistamines (suprastin, erius, claritin, others) and calcium supplements are used. In case of severe intolerance, the drug is discontinued.

When administered intranasally, side effects, as a rule, do not develop. Only in the case of treatment of sinusitis, when intracavitary lavage of the sinuses is performed, unpleasant side symptoms may appear.

Is it possible to use dioxidin for a runny nose in a child?

Many parents are wary of prescribing dioxidine, and this is justified. The instructions clearly warn that the drug is intended for adults only. But, despite such instructions, otolaryngologists still use dioxidin in children in the treatment of various options runny nose.

Due to the fact that there is completely no information in the instructions for the use of dioxidin in childhood, as well as its use for a runny nose, parents should make a decision together with their doctor, weighing the pros and cons: to use the drug for treatment or not.

Practitioners speak positively about dioxidine and believe that its use is often justified. Special complications They did not notice any serious consequences during treatment of the runny nose with dioxidine.

Dioxidin is often used for inhalation for the common cold, including for children. You need to start using this treatment method only with the permission of your doctor.

Can dioxidin be used in pregnant women?

Dioxidin has a teratogenic effect, and this can cause irreparable malformations of the fetus. Therefore, it is not recommended to use the drug during this period of a woman’s life, especially at the most early stages pregnancy (up to the 12th week).

Drawing conclusions

After reading the article, many wondered whether it is worth treating a runny nose with dioxidine if there are no clear instructions for use in this pathology.

You will have to decide for yourself. Although few patients study the instructions and more often trust the doctor’s experience.

The positive thing is that the drug has long been tested in practice and shows excellent results in the treatment of rhinitis. Negative trait- there are no scientific conclusions on the use of dioxidin in ENT practice.

The ideal is not to let the disease progress and treat a runny nose without leading it to protracted forms and the development of sinusitis. Try to use the funds traditional medicine and traditional drugs that long years effectively eliminate inflammation of the nasal mucosa. And only in case of urgent need to resort to “heavy artillery” - dioxidin!

One milliliter of a 1 percent solution for external and intracavitary use contains 10 mg , as well as water for injection in a volume of up to 1 ml.

A milliliter of 0.5 percent solution for local, intravenous and intracavitary use contains 5 mg hydroxymethylquinoxaline dioxide and water for injection as excipient(in a volume of up to 1 ml).

A gram of Dioxidin ointment contains 50 mg, as well as excipient substances: polyethylene oxide 400, polyethylene oxide 1500, nipagin, propyl ester of paraoxybenzoic acid.

Release form

The drug has the following dosage forms:

• Dioxidin solution 1% for intracavitary and local use;
• Dioxidin solution 0.5% for local, intravenous and intracavitary use;
• Dioxidin ointment 5%.

A one percent solution is available in 10 ml colorless glass ampoules, 10 ampoules in one package; a 0.5% solution is supplied to pharmacies in colorless glass ampoules of 10 and 20 ml; The ointment is packaged in tubes of 25, 30, 50, 60 and 100 grams.

pharmachologic effect

Dioxidin is a drug from the group synthetic antibacterial bactericidal drugs . The active substance of the drug belongs to the group of derivatives quinoxaline and is characterized wide range pharmacological activity.

Pharmacodynamics and pharmacokinetics

The mechanism of action of Dioxidin is associated with damaging effects hydroxymethylquinoxaline dioxide on cell walls microorganisms , which ultimately suppresses their vital activity and leads to their death.

The drug is active against Proteus vulgaris (Proteus vulgaris), Friedlander sticks , Pseudomonas aeruginosa (Pseudomonas aeruginosa), the causative agent of bacterial dysentery from sort of shigella (Shigella dysenteria, Shigella flexneri, Shigella boydii, Shigella sonnei), salmonella , which is the most common pathogen acute (Salmonella spp.), coli (Escherichia coli), staphylococci (Staphylococcus spp.), streptococci (Streptococcus spp.), which are pathogens foodborne diseases pathogenic anaerobic bacteria Clostridium perfringens.

Dioxidine is able to affect resistant to other antimicrobial agents (including but not limited to) strains of bacteria. In this case, the product does not cause local irritation.

The possibility of developing drug resistance to the drug cannot be ruled out.

When administered into a vein, it has a small therapeutic breadth of action, which in turn implies strict compliance the dosage regimen specified in the instructions.

Treatment of burned areas of the body with the drug, as well as purulent-necrotic wounds , allows you to accelerate the healing process of the wound surface, reparative (restorative) tissue regeneration, as well as their marginal epithelization, has beneficial influence on the course of the wound process.

Experimental studies have established that the drug is capable of providing teratogenic , mutagenic And embryotoxic action.

When used as local remedy partially absorbed from the wound or burned surface treated with it. It is eliminated from the body by the kidneys.

After injection into a vein, the therapeutic concentration hydroxymethylquinoxaline dioxide persists for the next 4-6 hours. Plasma concentration after a single injection of the solution reaches a maximum after approximately 1-2 hours.

The active substance quickly and easily penetrates all tissues and internal organs, excreted by the kidneys. At repeated administrations does not accumulate in the body.

Indications for use

Indications for IV administration of Dioxidin are:

• septic conditions (including conditions developing against the background of burn disease);
• purulent (purulent-inflammatory damage to the membranes of the brain);
• accompanied by symptoms of generalization purulent-inflammatory processes .

Intracavitary administration of Dioxidin in ampoules is indicated for leaks in the chest or abdominal cavity purulent-inflammatory processes , including when:

• purulent pleurisy (pleural empyema);
• peritonitis (inflammatory process affecting the parietal and visceral leaves peritoneum);
• (inflammation of the bladder);
• empyema of the gallbladder (acute purulent inflammation gallbladder).

Intracavitary injections may also be prescribed in for preventive purposes to prevent the development infectious complications after bladder catheterization .

Dioxidin is used as an external and local remedy:

• For burn treatment , trophic ulcers And wounds (including deep and superficial, of various locations, infected and purulent, difficult and long-term healing);
• for the treatment of wounds characterized by the presence deep purulent cavities (For example, purulent pleurisy , soft tissue abscesses , phlegmon And pelvic abscesses , postoperative wounds on the organs of the urinary and biliary system, purulent mastitis etc.);
• for the treatment of those provoked by activity streptococci or staphylococci infectious skin lesions (pyoderma).

Contraindications

The use of Dioxidin is contraindicated:

• at hypersensitivity to the components of the drug;
• at adrenal insufficiency (including if it is noted in the anamnesis);
• at ;
• at ;
• V pediatric practice .

The drug is prescribed with caution to patients with chronic .

Side effects

Intracavitary administration and administration of Dioxidin into a vein may be accompanied by:

• chills ;
• dyspeptic disorders , which are expressed in the form nausea, diarrhea And vomiting ;
• increased body temperature;
• unexpected convulsive muscle twitching ;
• photosensitizing effect (the appearance of pigmented spots on the body when the skin is exposed to ultraviolet rays);

At local application Dioxidine may be observed near-wound and on the area of ​​the body treated with the drug.

Instructions for use of Dioxidin (Method and dosage)

Instructions for use of Dioxidin in ampoules

Dioxidin is administered intravenously by drip. At severe purulent-septic conditions Before administration, the solution is pre-diluted with an isotonic solution (5% dextrose solution or 9% NaCl solution) to obtain a concentration of 0.1-0.1%.

The maximum permissible single dose is 0.3 grams, daily dose is 0.6 grams.

In cases where the patient is indicated for external use of Dioxidin, the drug is used for packing deep wounds, as well as irrigating affected areas of the body.

After preliminary cleaning and treatment, deep wounds are recommended to be loosely tamponed with tampons soaked in a 1% solution.

If the patient has a drainage tube, he is advised to administer 20 to 100 ml of a 0.5% solution into the cavity.

Therapy deep purulent wounds on the hands or feet involves the use of Dioxidine solutions (0.5 or 1%, as indicated by the attending physician) in the form of baths.

Special treatment of the wound surface for 15-20 minutes is also allowed: the drug is injected into the wound for the specified time, after which a bandage with a 1% solution of the drug is applied to the affected area of ​​the body.

Treatment of superficial infected purulent wounds involves applying wipes soaked in a 0.5 or 1% solution to the wound surface.

It is recommended to repeat the procedure daily or every other day (the frequency of applications depends on the condition of the wound and the characteristics of the wound process). The highest daily dose is 2.5 grams. Treatment with Dioxidin is usually continued for up to 3 weeks.

Patients with osteomyelitis , and if the drug is well tolerated, in some cases treatment can be continued for 1.5-2 months.

If intracavitary administration of the drug is necessary, the patient should inject 10 to 50 ml of a 1% solution into the cavity daily through a catheter or drainage tube. The drug is administered using a syringe, usually once. In some cases, Dioxidin may be administered in 2 doses according to indications.

The course of treatment lasts from 3 weeks. If appropriate, it is repeated after 1-1.5 months.

The highest daily dose for intracavitary administration is 70 ml.

Instructions for use of Dioxidin in the ear

For treatment of otitis It is usually customary to use vasoconstrictor drugs . However, in cases where they are not effective, Dioxidin becomes the drug of choice, a feature of which is its effectiveness against anaerobic bacteria .

Before instilling the medicine, it is recommended to clean the ear canal from wax using a cotton swab soaked in a 3% solution or special cotton swabs (for convenience auricle slightly pulled back). If the ear is very dirty, leave the tampon with peroxide in it for about 5 minutes.

At purulent otitis , which is often accompanied by perforation eardrum and the release of pus, before instillation, all purulent contents are first removed from the ear canal.

At otitis Dioxidine should be injected simultaneously into the nose and ear canal. The solution effectively sanitizes the nasal cavity and stops the inflammatory process in it, and since the nose is connected to the ear eustachian tube, relieving the inflammatory process in the nose has a beneficial effect on the situation as a whole.

The dose and frequency of instillations are selected individually in each specific case and exclusively by the attending physician.

According to the instructions for use, Dioxidin drops are prohibited from being prescribed to patients under 18 years of age. However, in some situations, when it is not possible to achieve an effect using other means, pediatricians prescribe the medicine even to small children.

Instructions for use of Dioxidin in the nose

For the treatment of adult patients, the drug should be pre-diluted with NaCl solution, hydrocortisone or water for injection before instillation. Dosage in the nose for an adult - from 2 drops to ⅓ pipette. Dioxdin drops are dripped into the nose 3 to 5 times a day. More precisely, the dose and the required frequency of procedures are determined by the attending physician.

The maximum duration of treatment should not exceed 7 days. If after this period the patient does not show improvement, he needs thorough examination and prescribing appropriate treatment based on its results.

There are no official instructions for the use of Dioxidin in the nose for children. However, if appropriate, doctors also use the drug to treat children. Before instilling Dioxidin into the nose, the solution should be diluted to a concentration of 0.1-0.2%. As in the situation with adults, the doctor selects the treatment regimen individually.

As a rule, Dioxidin is administered to a child’s nose 1-2 drops 2 or 3 times a day for 3-5 (maximum 7) days.

Inhalations with Dioxidin for adults

Inhalation therapy is one of the main types treatment of respiratory tract diseases .

To prepare a solution for inhalation, the medicine is diluted saline solution in a ratio of 1:4 for a drug with a concentration of 1% and in a ratio of 1:2 for a drug with a concentration of 0.5%.

For one procedure, 3 to 4 ml of the resulting solution is used. The frequency of procedures is 2 times a day.

Dioxidin ointment: instructions for use

Overdose

In case of an overdose of Dioxidin, it is possible development of acute adrenal insufficiency , which involves immediate discontinuation of the drug and the appointment of appropriate hormone replacement therapy.

Interaction

Patients with hypersensitivity To hydroxymethylquinoxaline dioxide , Dioxidin is prescribed in combination with antihistamines or calcium supplements.

Terms of sale

On prescription.

Storage conditions

Best before date

24 months.

special instructions

Prescription of Dioxidin is resorted to only in cases where the use of other antimicrobial drugs (including carbapenems , fluoroquinolones , cephalosporins of II-IV generations ) did not give the expected effect.

For patients with chronic renal failure, the dosage regimen should be revised towards a lower dose.

When administered intravenously, Dioxidin has a narrow therapeutic range, which requires constant monitoring of compliance with the recommended dosage regimen.

To prevent the development side effects treatment with Dioxidin is supplemented with prescription antihistamines And calcium preparations . If adverse reactions do occur, the dose is reduced and the patient is prescribed antihistamines .

In some cases, the appearance adverse reactions is a reason to discontinue the drug.

When appearing on the skin age spots the dose should be reduced while increasing the duration of its administration ( single dose administered one and a half to two hours before) and supplementing therapy with antihistamines.

If crystals appear in ampoules with the drug during storage (usually if the temperature drops below 15°C), it is recommended to dissolve them by heating the ampoules in a water bath (the water should boil) and shaking them periodically until the crystals are completely dissolved.

The solution should be completely transparent. If, after cooling it to 36-38°C, crystals do not form, Dioxidin is considered suitable for use. , , Urophosphabol , -Teva , Zenix , Amizolid , Dioxicol .

Quinoxidine

Dioxidin for children The drug is not intended for the treatment of children and adolescents under 18 years of age. This contraindication mainly due to possible hydroxymethylquinoxaline dioxide .

toxic effect

However, in certain situations, when the expected benefit to the child outweighs the potential risks, the doctor may neglect this limitation. If Dioxidin is prescribed, treatment should be carried out in a hospital setting or under the constant supervision of the attending physician. In pediatrics, Dioxidin solution is most often used to treat ENT diseases , mainly, purulent forms rhinitis or sinusitis . It is considered most appropriate to use a medicine with a concentration 0,5%.

active substance

In addition, the solution and ointment can be used to treat wound surfaces. A solution with a concentration of 0.5% is prescribed if the patient has deep lesions.

However, Dioxidin with such a dosage of the active substance should not be used for a long time. Therefore, as the condition of the wound improves, they switch to a 0.1% solution or ointment.

Dioxidin for a runny nose The drug is not available in the form of nasal drops, therefore, before dripping Dioxidin into the child’s nose, the contents of the ampoule are diluted hypertonic solution hydroxymethylquinoxaline dioxide 0,1-0,2%.

until a solution with a concentration is obtained Nasal drops for children are recommended to be administered three times a day, one or two in each nostril, best after instillation of vasoconstrictor drugs that reduce tissue swelling and relieve nasal breathing

. When carrying out the instillation procedure, the patient should tilt his head back so that the medicine penetrates as deeply as possible into the nasal passages.

Dioxidine in the ear

Insertion of Dioxidin into the ear is indicated for severe forms acute inflammation middle ear , in cases where prescribed to a child antibiotics do not give the desired effect.

The solution in ampoules is instilled into the ear twice a day. Moreover, for otitis media, the procedures are also supplemented with nasal drops.

The drug is not ototoxic and does not affect the auditory nerve.

Dioxidin for sinusitis

Dioxidine in ampoules is often used in therapy infectious processes, localized in paranasal sinuses nose At sinusitis the solution is used in the form of inhalations or as nasal drops. Drops are administered two or three into each nasal passage. The procedures are repeated 2 times a day.

For treatment sinusitis can be used and complex drops, which are prepared using dioxidine solutions, and. Complex drops are administered one into each nasal passage 4-5 times during the day.

Compound drops are prepared according to a prescription prescribed by a doctor in a pharmacy or at home.

Dioxidine is an antibacterial drug from the group of quinoxaldine derivatives.

It has a bactericidal, antibacterial action for various pathogens: Pseudomonas aeruginosa, staphylococci, pathogenic anaerobes and other strains of bacteria resistant to other antibiotics.

It is usually used in a hospital setting for the treatment of septic conditions, as it is a reserve antibacterial drug. Its effectiveness is combined with high toxicity, so the drug is prescribed only if treatment with other, less toxic antibiotics fails.

On this page you will find all the information about Dioxidin: full instructions as applied to this medicine, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Dioxidin in ampoules. Would you like to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Antibacterial drug, quinoxaline derivative.

Conditions for dispensing from pharmacies

Dispensed with a doctor's prescription.

Prices

How much does Dioxidin cost? average price in pharmacies it is at the level of 300 rubles.

Release form and composition

Dioxidin has several forms of release:

• ointment 5%;
• Dioxidine solution (0.5%) for intravenous injections;
• Dioxidine in ampoules for inhalation (5 mg) and intracavitary use (1%).

Dioxidin 1% solution is available in 10 ml glass ampoules. 1 ml of a clear, colorless solution contains 10 mg of the active ingredient dissolved in water for injection.

Dioxidin 5 mg for inhalation is produced in ampoules of 10 and 20 ml. In each milliliter of the drug in water for injection, 5 mg of hydroxymethylquinoxaline dioxide is dissolved. Ampoules containing solution for injection and inhalation are placed in 10 pieces in cardboard packages.

Pharmacological effect

Dioxidine is synthetic bactericidal agent, which is used in the treatment of purulent and infectious pathologies. Usually the drug is used externally, however, if necessary, intracavitary lavage and intravenous administration are allowed.

Dioxidin has a detrimental effect on pathogenic cells by inhibiting the formation of DNA, but does not affect the production of RNA and protein. Also, the main active ingredient destroys the microbiological structure (shell and nucleotides that play important role in the formation of intracellular energy).

The drug is widely used in medicine due to its effective suppression of pathogenic flora in anoxic conditions.

Indications for use

According to the instructions, Dioxidin is indicated for use when bacterial infections, sensitive to active component drug.

External use of Dioxidin is advisable in the following cases:

1. Infected burns;
2. Soft tissue phlegmon;
3. Deep or superficial wounds on the body;
4. and long-term non-healing wounds;
5. Purulent wounds with osteomyelitis.

Intracavitary administration of Dioxidin is indicated in the following cases:

1. Peritonitis;
2. Abscesses;
3. Purulent pleurisy;
4. Purulent processes in the abdominal or thoracic cavity;
5. Wounds of the biliary and urinary tract;
6. Pleural empyema;
7. Wounds and phlegmon with the presence of deep purulent cavities (pelvic cellulitis, soft tissue abscesses, purulent mastitis, postoperative wounds biliary and urinary tract).

Contraindications

Dioxidin is contraindicated for:

• individual intolerance to the drug;
• dysfunction of the adrenal glands;
• pregnancy and lactation;
• under 12 years of age.

Despite the obvious positive effect of the drug in the treatment of purulent-microbial pathologies, the high toxicity of dioxidin has determined it to be a reserve drug, especially for intravenous infusions.

Use during pregnancy and lactation

The effect of hydroxymethylquinoxylin dioxide on the body has been studied over many years of research. As a result, its mutagenic and teratogenic effects were reliably established.

Women at any stage of pregnancy should not be prescribed this drug, and not only intravenously or into the body cavity. Even topical use in the form of ointments, compresses or nasal drops ensures penetration active substance into the bloodstream through mucous membranes and skin. For the same reason, treatment with Dioxidin during lactation is excluded (a temporary transition to pumping and artificial feeding is usually recommended).

Instructions for use

The instructions for use indicate that Dioxidin is most often used in inpatient conditions. A 1% solution of the drug is usually not used for intravenous injections (due to the instability of the drug during storage). low temperatures). Use 0.1-1% solutions, for which the drug is diluted with water for injection or sodium chloride solution.

External use of Dioxidin:

1. To prevent infections after operations, Dioxidin is used in the form of a 0.1-0.5% solution.
2. When treating superficial infected purulent wounds, wipes soaked in a 0.5-1% solution of Dioxidin are applied to the wound. When treating deep wounds, they are loosely tamponed with tampons pre-moistened in a 1% solution. If there is a drainage tube, a 0.5% solution, from 20 to 100 ml, is injected into the cavity.
3. For the treatment of deep purulent wounds with osteomyelitis - in the form of baths with a 0.5-1% solution. Less often carried out special treatment wounds by injecting the drug for 15-20 minutes, then apply a bandage with a 1% Dioxidine solution. If the drug is well tolerated, treatment can be carried out daily for 1.5-2 months.

For intracavitary administration, a catheter, syringe or drainage tube is used. IN purulent cavity a 1% solution of the drug is administered, the dose depends on the size of the cavity, usually 10-15 ml per day. Usually the drug is administered once a day. The maximum daily dose is 70 ml. Treatment can be continued for three weeks or more if indicated and well tolerated.

Instructions for use of Dioxidin in the nose

Dioxidin solution is used in the presence of complicated inflammatory processes in the nasal cavity, in particular for the treatment of sinusitis, sinusitis, frontal sinusitis and other pathologies. The nasal cavity is washed with Dioxidin solution 2-3 times a day, using a syringe for convenience.

The drug has excellent therapeutic effect for complicated sinusitis, when others medications, including antibiotics, are ineffective. Pierced maxillary sinuses washed with a solution of the drug 2-3 times a day, after which, if necessary, gauze turundas soaked in the solution are inserted into the nasal cavity.

Dioxin in the ear

To treat otitis media, it is usually customary to use antibiotics and vasoconstrictor drugs. However, in cases where they are not effective, Dioxidin becomes the drug of choice, a feature of which is its effectiveness against anaerobic bacteria.

Before instilling the medicine, it is recommended to clean the ear canal from wax using a cotton swab soaked in a 3% hydrogen peroxide solution or special cotton swabs (for convenience, the auricle is slightly pulled back). If the ear is very dirty, leave the tampon with peroxide in it for about 5 minutes.

1. In case of purulent otitis media, which is often accompanied by perforation of the eardrum and discharge of pus, all purulent contents are first removed from the ear canal before instillation.
2. For otitis, Dioxidin should be injected simultaneously into the nose and into the ear canal. The solution effectively sanitizes the nasal cavity and stops the inflammatory process in it, and since the nose is connected to the ear by the Eustachian tube, relieving the inflammatory process in the nose has a beneficial effect on the situation as a whole.

The dose and frequency of instillations are selected individually in each specific case and exclusively by the attending physician.

Dioxidin ointment

Used for the treatment of purulent wounds, trophic ulcers, phlegmon, wounds with osteomyelitis, pustular skin rashes. Apply to the surface of the skin thin layer, tampons with ointment are inserted into purulent wounds. Daily dose for adults should not be more than 2.5 g. Duration of use of the product is 3 weeks.

Inhalation with a nebulizer

Today, a nebulizer is popular in the treatment of coughs and runny noses. However, not all owners of a useful device know which solutions are suitable for inhalation and which are not. What doctors say about the use of Dioxidin in nebulizers and inhalers.

The solution can be used at home, but under strict control of the dosage of Dioxidin. Inhalations are prescribed for lung abscesses, pleural empyema, severe inflammation of the bronchi. Dioxidin is rarely prescribed for sinusitis, frontal sinusitis, sinusitis - in case of protracted course of the disease and the appearance of resistance (immunity) to other (weaker) drugs.

The concentrated solution is not poured into the nebulizer; it is diluted with saline solution. How to dilute Dioxidin correctly?

• ampoules with a 1% solution are diluted in a ratio of 1:4;
• ampoules with a 0.5% solution are diluted in a ratio of 1:2.

One inhalation will require 3 ml. What is left can be stored in the refrigerator for no more than 12 hours. The only point is that before inhalation, Dioxidin should be removed from the refrigerator compartment to warm it up naturally. The solution must not be heated!

Side effects

Dioxidin when administered intracavitarily can cause:

• dyspeptic disorders;
• convulsive muscle contractions;
• allergic reactions;
• headache;
• chills;
• rising temperatures;
• photosensitizing effect (appearance of pigmented spots on the body when exposed to sunlight);
• periwound dermatitis (for external use).

When used externally, Dioxidin can cause periwound dermatitis.

Overdose

Symptoms of overdose include: excessive symptoms from the list of side effects, and acute failure functions of the adrenal cortex:

1. To cope with the difficulty of synthesizing corticosteroids (stress hormones), therapy must be stopped.
2. For other manifestations of overdose they select therapeutic methods- symptomatic treatment.

Substitution is allowed hormone therapy– in the form of doses of glucocorticosteroids determined by the doctor (normally up to 1 mg per kilogram of the patient’s weight).

special instructions

1. The drug is prescribed only if other antibacterial drugs are ineffective, including fluoroquinolones, cephalosporins of II-IV generations, carbapenems.
2. Before starting to use Dioxidin, a drug tolerability study must be carried out. To do this, a small volume (10 ml) of a 1% solution is injected into the cavities and the patient’s condition is monitored for 3-6 hours. If during this time there is no side effects(chills, fever, dizziness), the drug can be used for a course of treatment.
3. If pigment spots occur, increase the duration of a single dose to 1.5-2 hours, reduce the dose, discontinue dioxidine or prescribe antihistamines.

It’s good when the drug has clear instructions describing when, how and how much it should be used. You can go to the pharmacy, buy such a medicine and immediately receive comprehensive information about the treatment regimen. However, sometimes we are unable to obtain the information we need from a trusted source. For example, dioxidin, which some ENT doctors recommend using for instillation into the nose for a runny nose, turns out to be not intended for this at all.

Due to the fact that the instructions for this product do not contain a word about use for rhinitis, we will construct our story in the form of a question and answer. Let's hope you understand everything the right moments, and by the end of the article you will not have any unclear points regarding this drug.

• What is dioxidin, what group of drugs does it belong to and how does it work?

Dioxidin is an antibacterial agent that has a detrimental effect on many pathogenic microorganisms, including from the composition of pyogenic flora.

• What are the indications for the use of dioxidin?

This drug is usually prescribed when antibiotics are ineffective and is used for serious illnesses: purulent inflammation of the pleura, abscesses, infected wounds, phlegmon. The annotation does not say anything about its use in ENT practice, although in some cases doctors prescribe this drug to treat a runny nose.

• How is dioxidin administered?

To treat the diseases listed in the annotation, the medicine is used either externally, intravenously, or by intracavitary administration. For rhinitis, doctors recommend instilling the solution into the nasal passages.

• In what form is the drug available? Is there a special form for instillation into the nose?

Dioxidine can be found in the form of 1% and 0.5% solution in 10 ml ampoules. Special shapes for insertion into the nose does not exist.

• How to instill dioxidine?

Doctors who prescribe this drug advise doing this: open the ampoule, after making a notch on it with a special file, take the medicine into a pipette, and drip the required amount of solution into both nostrils. Before this, the patient must clear the nose of mucus and crusts and tilt his head back so that the product gets into the nasal cavity and is well distributed along its walls.

• If the entire ampoule of medicine is not used in a day, can it be stored?

Ideally, no, a new one should be used every day. However, in some cases, ampoules are stored for up to 24 hours by placing a piece of cotton wool in the neck (instead of a lid) and placing the medicine in the refrigerator. Before use, the solution is warmed again.

• How many drops should I use?

• What is the course of intranasal use of dioxidine?

Doctors urge their patients to limit themselves to 3-5 days of treatment, a maximum of a week.

• Do I need to dilute dioxidin before use?

A 0.5% solution is not diluted; a 1% solution is diluted twice with water or saline.

• How effective is the drug?

• Is dioxidin administered nasally to children? Isn't this dangerous?

The instructions strictly state that the product is used only in adults, but ENT doctors recommend using it in children, which is done quite often. Meanwhile, there is no official data on the intranasal use of this medicine; it is not included in the treatment standards; negative consequences The data is also not collected. Moreover, the product does not have evidence base– information clearly confirming the safety of its use. In other words, the possibility of using dioxidine in a child should be determined by parents, at their own peril and risk. However, so far the use of this drug has not been associated with any complications or negative aftereffects. Although very young infants and infants should definitely avoid such medications...

• What exactly is the danger of the drug?

It's toxic, it's therapeutic dose only slightly less than toxic, but given that when surgical diseases Patients are given 30-40 ml of the product; there is no need to be afraid of this. Although, if the doctor recommends instilling small child half a pipette of medicine (about 10 drops) several times a day, it is better not to listen to him and choose an alternative solution.

• Can dioxidin be administered nasally to pregnant women?

Dioxidin has a teratogenic effect, that is, it can cause developmental defects in the fetus. If you unknowingly use the product 1-2 times, most likely it will not cause any consequences, but you should not use it in the system.

• Is it true that dioxidin is included in many types of combined drops for the common cold?

No it is not true; the use of dioxidine is an “invention”, the feasibility of which is confirmed by the experience of doctors, but is not approved by the scientific community and has not been studied. Included finished drugs this substance does not exist.

• So can you use dioxidin nasal drops or not?

Surely this article left you with a feeling of some uncertainty in your soul, because you still did not find a clear decision on whether to use the drug or not. Well, let's figure this out.

On the one hand, we have a fairly noticeable effect from the use of the medicine, on the other hand, the use of dioxidin and its possible consequences have not been studied, and the doses and duration of treatment recommended for people were selected empirically and not based on verified data. Thus, everyone is left to decide for themselves whether to use the medicine or not. If you just want to hear someone’s advice, then listen to the author’s opinion. Perhaps the smartest thing to do would be to first try to cure a runny nose with traditional medications, and then, if they don’t help, start experimenting. Still, the drug we are talking about is much less safe than others possible options remedies for rhinitis. There is a pretty good chance that you will find among those that are definitely permitted and safe, and you will never have to deal with dioxidine solution.

Dioxidin is antibacterial drug from the group of quinoxaline derivatives, has a wide spectrum of action and chemotherapeutic activity against many infections. Dioxidin in the ampoule is active against many pathogenic and non-pathogenic microbes: Klebsiella, Pseudomonas aeruginosa, Salmonella, pathogenic anaerobes (including causative agents of gas gangrene), dysentery bacillus, staphylococci and streptococci. The drug affects strains of many bacteria that have proven resistant to other antibiotics and chemotherapy drugs.

Effect of the drug Dioxidin

Irrational use of the drug can lead to the development of drug resistance in bacteria, which is why when using Dioxidin in an ampoule, you must follow the dose recommended by your doctor. The drug is used for the treatment of purulent-necrotic and burn wounds, as a result of which the surface is quickly cleaned, regeneration and epithelization of damaged areas occurs. The drug is often used to treat chronic, indolent infections that are difficult to treat. When applied externally, Dioxidin is partially absorbed and excreted in the urine.

Dioxidine in ampoule: indications for use

The drug is often used externally for purulent bacterial infections, trophic ulcers and for a long time non-healing wounds, as well as for infected burns, phlegmon and osteomyelitis. At purulent otitis Drops of it are quite effective and are sometimes used for advanced purulent sinusitis. In some cases, Dioxidin is used for inhalation, and is also injected into cavities during purulent processes in various organs, with pleurisy, with wounds with deep cavities. In case of periodontal disease, it is permissible to rinse the mouth with Dioxidin, however, this is done very carefully, avoiding ingestion of the drug.

Dioxidine in ampoule: contraindications

Contraindications to the use of the drug are individual intolerance, pregnancy and lactation, adrenal insufficiency, childhood up to seven years, in some cases - renal failure. When treating with Dioxidin, the patient’s health status and medical history should be taken into account. If the patient has chronic diseases or he has an unfavorable heredity, the doctor must assess all the risks associated with the use of the drug and compare them with the expected effect.

Method of application and dosage of Dioxidin

For intravenous administration You cannot use a 1% solution of Dioxidin, as it tends to crystallize at low temperatures. Externally use 0.1-0.5-1% solutions of Dioxidin. When treating purulent and burn wounds, wipes soaked in a sterile solution are used. At deep wounds tampons are also used, also soaked in a solution of the required concentration of Dioxidine, and if there is drainage, the drug is injected into the cavity (up to 100 ml). Sometimes baths with Dioxidin are used to treat purulent wounds, in particular they are used for osteomyelitis of the hands and feet, followed by the application of sterile dressings with the drug.

Dioxidine in ampoules is an excellent anti-inflammatory drug that is simply necessary for the treatment of certain diseases. However, with all the advantages of the drug, in large doses it becomes a poison for the body, capable of destroying living active cells. That is why it is not recommended to use Dioxidin in ampoules without a doctor’s prescription, or to violate his instructions and dosages. Local use of the drug is also unacceptable without consulting a doctor, as is intracavitary use.