The drug "Metronidazole" is an analogue of "Trichopol." What analogues of Trichopolum exist?

Description of drugs

Many medications have analogues with similar composition and effects. Such analogue drugs include Trichopolum and Metronidazole. Both drugs are prescribed to combat infections caused by microbial agents. They have no effect on fungal infections.

Is Metronidazole an antibiotic? This question is of interest, thanks to negative attitude population to the effect of antibiotics on the body. No, in its formula Metronidazole has chemical formula, not extracts from natural ingredients. Therefore, Metronidazole (Trichopol) cannot be called an antibiotic - it is an antimicrobial agent.

The medicinal substance of these drugs actively spreads throughout the tissues and fluids of the body, acting directly on microbial agents. After 8 hours, metronidazole half-life occurs and is excreted from the body along with feces (urine/feces).

Which medicine is better? It is impossible to answer the question unambiguously: both drugs have the same therapeutic formula.

In order to understand how substitutes differ from Trichopolum, you should find out what this medicine is. The drug has an effect on large number microbes, as well as some protozoa. In addition, it can be prescribed for the treatment of anaerobic infection.

Excretion is carried out mainly by the kidneys, in a volume of 4/5. The remaining part is excreted by the intestines. Observed complete cleansing the body from the components of the drug after eight hours. This fact should be taken into account when drawing up a dosage regimen. If necessary, Trichopolum can be used topically, for example, in the form of vaginal suppositories or in the form of a cream.

If the liver is damaged, the time during which the components of the drug are eliminated increases significantly, which requires a reduction in dosage.

In general, the drug is easily tolerated, suitable for a large number of patients and quickly copes with many pathologies. Possible side effects may include nausea, allergic reaction, stool disorders. In addition, it should be remembered that during pregnancy, Trichopolum analogues and the original drug are not used.

Failure to comply with the rules for using the drug leads to nausea

Differences between Trichopolum and Metronidazole

There are no differences between the products, except for the method of administration and dosages of different forms and auxiliary components.

Trichopolum is produced in the form of tablets and solutions for injection. Metronidazole comes in 3 forms:

tablet;
solution for injection;
suppositories.

Medicines also differ in price. Metronidazole is cheaper.

Trichopolum today is a particularly popular drug with an antimicrobial effect. It is often prescribed by doctors to treat a large number of pathologies. But besides this, it is important to emphasize that today pharmaceutical market provides a huge number of analogues of Trichopolum. They all differ in cost, release form, appearance and, of course, manufacturer. But they have one thing in common - the active ingredient in all existing analogues There will only be metronidazole. For this reason, it is important to find out what can replace the drug if this particular name is not available in the pharmacy chain, and whether the effectiveness of the drug and the likelihood of side symptoms depend on the name.

An effective remedy for helminthiasis is Trichopolum, but it can be replaced with analogues

Use of the drug during pregnancy and lactation

Metronidazole penetrates the placental barrier, therefore Trichopol® is contraindicated for use in the first trimester of pregnancy. The use of the drug in the second and third trimesters is possible only in cases where the expected benefit to the mother outweighs the potential risk to the fetus.

You are still studying information, reading about medicines designed to defeat the infection, but what exactly should you do?

Other medicines in our pharmacy

Both categories of these drugs are widely used in medicine, but the latter have a much higher cost. Let's take a closer look at the most common medications included in these groups.

The first and most popular analogue of Trichopolum is Metronidazole. This is a domestic drug, different minimum price, But high efficiency. The drug is produced at several pharmaceutical plants at once. It can be found in the pharmacy in the form of a solution and tablets. It is important to note that the dosage will be different even for the same release form. Yes, a drug for intramuscular injection may have either 250 or 500 mg of active ingredient.

The advantage of Metronidazole is that its bioavailability in some patients reaches 100 percent. Even small amounts of the substance are found in cerebrospinal fluid. In other words, even with serious deviations, the patient can limit himself to the tablet form. Only when in serious condition Doctors prescribe injections for the patient.

The effect after using this analogue is observed after a couple of hours. It is removed in 7-9 hours. If the filtration function of the liver is insufficient, time complete removal increases.

Important: the drug easily penetrates the hematoplacental barrier and is detected in breast milk.

Trichopolum is often replaced with Metronidazole

Separately, we can highlight foreign analogues of the drug Trichopolum. There are also a large number of them, but some of them should be considered especially carefully. They are produced in different forms. Suppositories, tablets for vaginal administration, ointments, creams and capsules are quite common.

Flagyl. The drug is produced in France pharmaceutical company. Of all known drugs this one is the most expensive.
Metrogil. The drug is produced in India. You can buy it at a more attractive price. However, the medicine is well tolerated and rarely causes side symptoms. It is due to this that Metrogyl has become the most popular analogue of the above-described remedy.
Klion. A drug that is highly effective in the treatment of pathologies. Produced in Hungary. Like the original drug, it easily penetrates all tissues of the body and quickly has an effect on the source of pathology.

Each drug has the same active ingredient. The only differences will be in additional components. But still, the composition of the product should be studied especially carefully, since sometimes patients experience intolerance to substances that are inactive, but can provoke unpleasant consequences.

When choosing a drug, it is especially important to take into account the localization of the outbreak, since the form of release of the drug that is effective in a particular case directly depends on this.

Metronidazole enhances the effect of warfarin and other coumarin anticoagulants (with this combination, a reduction in the doses of both drugs is required).

Cimetidine inhibits the metabolism of metronidazole, which can lead to an increase in its concentration in the blood plasma and an increased risk of adverse reactions.

The simultaneous administration of drugs that stimulate the activity of microsomal liver enzymes (phenobarbital, phenytoin) can accelerate the elimination of metronidazole, which leads to a decrease in its concentration in the blood plasma.

In patients receiving long-term treatment with lithium high doses, when taking metronidazole, it is possible to increase the concentration of lithium in the blood plasma and develop symptoms of intoxication.

When taking metronidazole and cyclosporine in combination, an increase in the concentration of cyclosporine in the blood plasma may be observed.

Metronidazole reduces the clearance of fluorouracil, which may increase the toxicity of the latter.

When used concomitantly, metronidazole may increase plasma concentrations of bisulfan.

Similar to disulfiram, metronidazole causes ethanol intolerance. The simultaneous use of Trichopolum with disulfiram can lead to the development of various neurological symptoms(the interval between the use of these drugs should be at least 2 weeks).

Sulfonamides enhance antimicrobial effect metronidazole.

Similar to disulfiram, metronidazole causes ethanol intolerance. The simultaneous use of Trichopolum with disulfiram can lead to the development of various neurological symptoms (the interval between the use of these drugs should be at least 2 weeks).

Contraindications to the use of the drug TRICHOPOL®

Depending on the diagnosis, the dosage of the medicine is selected. When infected with worms, treatment with Trichopolum or Metronidazole usually lasts 7 days. Sometimes, after a 7-day break, the patient is prescribed to take another course. The course of injections is usually 10 days.

When treating trichomoniasis, it is especially important to follow the doctor's instructions, not drink alcohol and avoid sexual contacts until the end of treatment. As an antibiotic, the drug has an effect on the bacterial environment of the intestines, so it is necessary to take drugs that restore the microflora.

Since both drugs are the same thing, they together cause a slowdown in reactions.

When treating with Metronidazole or Trichopolum, the following factors should be taken into account:

You cannot drive a vehicle or perform work that requires making quick decisions;
It is recommended to consume products with lactobacilli;
it is forbidden to combine with alcohol-containing products, since ethanol enhances the effect of the medicine, which can lead to negative consequences;
there are restrictions on simultaneous use with certain medications (barbiturates, disulfires, etc.).

For your information! Adjustments to the dosage and duration of use can be made on an individual basis.

Treatment of infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

trichomoniasis;
bacterial vaginosis;
all forms of amebiasis (diseases of intestinal and extraintestinal localization, including amoebic liver abscess, amoebic dysentery, as well as asymptomatic amebiasis);
giardiasis;
periodontal infections (including acute ulcerative gingivitis, acute odontogenic infections);
anaerobic bacterial infections(gynecological and abdominal infections CNS, bacteremia, sepsis, endocarditis, infections of bones and joints, skin and soft tissues, infections respiratory tract), caused by Bacteroides spp., Clostridium spp., Eubacterium spp., Peptococcus spp., Peptostreptococcus spp. and anaerobes sensitive to metronidazole;
treatment of infections Helicobacter pylori at peptic ulcer stomach or duodenum in combination with bismuth preparations and an antibiotic, for example, amoxicillin.
Prophylactic appointment before surgical intervention on the gastrointestinal tract and reproductive organs.

leukopenia (including history);
organic lesions Central nervous system (including epilepsy);
liver failure (if the drug is prescribed in high doses);
I trimester of pregnancy;
lactation period ( breast-feeding);
childhood up to 3 years;
increased sensitivity to metronidazole or other nitroimidazole derivatives.

The drug should be prescribed with caution to patients with renal and/or liver failure in the second and third trimesters of pregnancy.

When prescribing Trichopolum to patients with impaired liver function, the dosage regimen of the drug should be adjusted due to the possible accumulation of metronidazole in the body.

The drug should be prescribed with caution to patients with renal failure.

At renal failure severe (creatinine clearance less than 10 ml/min) daily dose Trichopolum should be reduced by 2 times.

Trichomoniasis;

Bacterial vaginosis;

All forms of amebiasis (diseases of intestinal and extraintestinal localization, including amoebic liver abscess, amoebic dysentery, as well as asymptomatic amebiasis);

Giardiasis;

Periodontal infections (including acute ulcerative gingivitis, acute odontogenic infections);

Anaerobic bacterial infections (gynecological and abdominal infections of the central nervous system, bacteremia, sepsis, endocarditis, infections of bones and joints, skin and soft tissues, respiratory tract infections) caused by Bacteroides spp., Clostridium spp., Eubacterium spp., Peptococcus spp., Peptostreptococcus spp. . and anaerobes sensitive to metronidazole;

Treatment of Helicobacter pylori infections in gastric or duodenal ulcers in combination with bismuth preparations and an antibiotic, for example, amoxicillin.

Prophylactic prescription before surgery on the gastrointestinal tract and reproductive organs.

Leukopenia (including history);

Organic lesions of the central nervous system (including epilepsy);

Liver failure (if the drug is prescribed in high doses);

I trimester of pregnancy;

Lactation period (breastfeeding);

- children under 3 years of age;

Hypersensitivity to metronidazole or other nitroimidazole derivatives.

Trichomoniasis;

Giardiasis;

Contraindications to the use of the drug

The products have an antimicrobial effect and are used to treat toxic, aerobic infections. Main indications for use:

Metronidazole, Trichopolum are contraindicated for people with diseases and conditions:

Childhood.
Blood diseases.
Pregnancy, lactation period.
Disturbances, disruptions of the nervous system.
Damage to the liver, kidneys.

If the dosage is not followed correctly, side effects may occur:

Vomit.
Headache.
Diarrhea.
Candidiasis is a fungal infection.
Allergy.

While using the products, it is prohibited to consume alcohol or alcohol-containing drugs; it is not recommended to drive vehicles or engage in activities that require increased concentration attention. At long-term therapy blood tests must be done weekly. If sexually transmitted infections, such as trichomoniasis, are being treated, any intimate contact should be avoided.

Unlike Metronidazole, the price of Trichopolum is higher due to its features.

The prescription of Trichopolum and Metronidazole has limitations.

The following conditions are contraindications for use:

dysfunction of the central nervous system;
severe liver disease;
kidney pathology;
breast-feeding;
childhood;
leukopenia;
pregnancy (1st trimester);
individual intolerance.

The difference between Trichopolum and Metronidazole is not significant. Trichopolum is approved for use while expecting a child, starting from the second trimester and in children over 6 years of age.

Metronidazole is an analogue of Trichopolum, their use can lead to similar side effects. Trichopolum has possible negative manifestations a little less.

Possible side effects:

allergic reactions;
problems falling asleep;
headache;
nausea;
dizziness;
urge to vomit;
joint pain, etc.

To reduce the negative impact of the antibiotic on the digestive system, it is possible to take the tablets after meals. IN in rare cases these medications can lead to intestinal disorders, rhinitis and other side effects.

Negative reactions to administration most often occur when the rules of administration are violated:

excess dosage;
ignoring contraindications, etc.

For your information! These medications should be taken strictly as prescribed by your doctor.

Trichomoniasis;

Giardiasis;

Trichomoniasis;

In this article you can read the instructions for use of the drug Trichopolum. Feedback from site visitors - consumers - is presented of this medicine, as well as the opinions of specialist doctors on the use of Trichopolum in their practice. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogs of Trichopolum if available structural analogues. Use for the treatment of vaginosis, trichomoniasis and others infectious diseases in adults, children, as well as during pregnancy and breastfeeding. Drug dosage regimen.

Trichopolum- antiprotozoal drug with antibacterial activity, a derivative of 5-nitroimidazole. The mechanism of action is the biochemical reduction of the 5-nitro group of metronidazole (the active ingredient of the drug Trichopolum) by intracellular transport proteins anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole interacts with the DNA of microbial cells, inhibiting the synthesis of their nucleic acids, which leads to the death of microorganisms.

In combination with amoxicillin, it is active in regarding Helicobacter pylori (amoxicillin suppresses the development of resistance to metronidazole).

Metronidazole does not have a bactericidal effect against most bacteria and facultative anaerobes, fungi and viruses. In the presence mixed flora(aerobes and anaerobes) Metronidazole exhibits synergism with antibiotics that are effective against common aerobes.

Metronidazole increases the sensitivity of tumors to radiation, causes sensitization to ethanol (alcohol) (disulfiram-like effect), and stimulates reparative processes.

Pharmacokinetics

After taking the drug orally, metronidazole is quickly and almost completely absorbed from the gastrointestinal tract. Eating reduces the rate of absorption and Cmax of metronidazole in the blood serum. Metronidazole penetrates into most tissues and body fluids, including lungs, kidneys, liver, skin, cerebrospinal fluid, brain, bile, saliva, amniotic fluid, abscess cavities, vaginal secretions, seminal fluid, breast milk, penetrates the blood-brain barrier and the placental barrier. The main metabolite (2-oxymetronidazole) also has antiprotozoal and antibacterial effect. Metronidazole is excreted by the kidneys - 60-80% (20% unchanged), through the intestines - 6-15%.

In elderly patients, renal excretion of metronidazole is reduced.

Indications

Treatment of infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

trichomoniasis;
bacterial vaginosis;
all forms of amebiasis (diseases of intestinal and extraintestinal localization, including amoebic liver abscess, amoebic dysentery, as well as asymptomatic amebiasis);
giardiasis;
periodontal infections (including acute ulcerative gingivitis, acute odontogenic infections);
anaerobic bacterial infections (gynecological and abdominal infections of the central nervous system, bacteremia, sepsis, endocarditis, infections of bones and joints, skin and soft tissues, respiratory tract infections) caused by Bacteroides spp., Clostridium spp., Eubacterium spp., Peptococcus spp., Peptostreptococcus spp. . and anaerobes sensitive to metronidazole;
treatment of Helicobacter pylori infections in gastric or duodenal ulcers in combination with bismuth preparations and an antibiotic, for example, amoxicillin;
prophylactic prescription before surgery on the gastrointestinal tract and reproductive organs.

Release forms

Tablets 250 mg.

Vaginal tablets (popularly called suppositories for some reason) 500 mg.

Instructions for use and dosage regimen

The drug is prescribed orally, during or after meals, the tablets are taken without chewing.

Trichomoniasis

Adults and children over 10 years of age are prescribed 250 mg (1 tablet) 3 times a day or 500 mg (2 tablets) 2 times a day for 7 days. Women must additionally be prescribed metronidazole in the form of vaginal suppositories or tablets. If necessary, you can repeat the course of treatment. Between courses you should take a break of 3-4 weeks with repeated control laboratory tests.

An alternative treatment regimen is to prescribe 750 mg (3 tablets) in the morning and 1250 mg (5 tablets) in the evening or 2000 mg (8 tablets) per day once. The duration of treatment is 2 days. Treatment is carried out simultaneously for both sexual partners.

Children aged 3 to 7 years are prescribed 125 mg (1/2 tablet) 2 times a day; aged 7 to 10 years - 125 mg (1/2 tablet) 3 times a day. The course of treatment is 7 days.

Bacterial vaginosis

Adults are prescribed 500 mg (2 tablets) 2 times a day for 7 days or 2000 mg (8 tablets) per day once. Simultaneous treatment of the sexual partner is not required.

Amoebiasis

For invasive forms of intestinal amebiasis in susceptible patients (including amoebic dysentery), adults and children over 10 years of age are prescribed 750 mg (3 tablets) 3 times a day. Children aged 3 to 7 years - 250 mg (1 tablet) 4 times a day; at the age of 7 to 10 years - 375 mg (1.5 tablets) 3 times a day. The course of treatment is usually 5 days.

For intestinal amebiasis in less susceptible patients and for chronic amoebic hepatitis, adults and children over 10 years of age are prescribed 375 mg (1.5 tablets) 3 times a day. Children aged 3 to 7 years - 125 mg (1/2 tablet) 4 times a day; aged 7 to 10 years - 250 mg (1 tablet) 3 times a day. The duration of the course of treatment is 5-10 days.

For amoebic liver abscess and other forms of extraintestinal amebiasis, adults and children over 10 years of age are prescribed 375 mg (1.5 tablets) 3 times a day. Children aged 3 to 7 years - 125 mg (1/2 tablet) 4 times a day; at the age of 7 to 10 years - 250 mg (1 tablet) 3 times a day. The course of treatment is 5 days.

For asymptomatic carriage of cysts, adults and children over 10 years of age are prescribed 375-750 mg (1.5-3 tablets) 3 times a day. Children aged 3 to 7 years - 125 mg (1/2 tablet) 4 times a day; at the age of 7 to 10 years - 250 mg (1 tablet) 3 times a day. The duration of the course of treatment is 5-10 days.

Giardiasis

Adults and children over 10 years of age are prescribed 500 mg (2 tablets) 2 times a day for 5-7 days; or 2000 mg (8 tablets) 1 time per day for 3 days.

Children aged 3 to 7 years - 250-375 mg (1-1.5 tablets) 1 time per day for 5 days, or 500-750 mg (2-3 tablets) 1 time per day for 3 days. Children aged 7 to 10 years - 250 mg (1 tablet) 2 times a day for 5 days, or 1000 mg (4 tablets) 1 time a day for 3 days.

Infections caused by anaerobic bacteria

Treatment of anaerobic infections usually begins with IV infusions. As soon as possible, treatment should be continued with metronidazole tablets.

Adults and children over 10 years of age are prescribed 500 mg (2 tablets) 3-4 times a day. The duration of treatment should not exceed 7 days.

For children under 10 years of age, the use of metronidazole in the form of infusion solutions is recommended for the treatment of anaerobic infections.

Helicobacter pylori eradication

Prescribe 500 mg (2 tablets) 3 times a day for 7 days (as part of combination therapy, for example, with amoxicillin 2.25 g/).

Suppositories or vaginal tablets

Intravaginally (deeply), after first releasing the tablet from the contour packaging and moistening it with boiled cooled water.

Trichomonas vaginitis: 1 tablet/day for 7-10 days in combination with taking the drug orally.

Nonspecific vaginitis, bacterial vaginosis: 1 tablet/day for 7 days (if necessary, combined with oral administration of the drug). The course of treatment is no more than 10 days and no more than 2-3 times a year.

Side effect

epigastric pain;
nausea, vomiting;
diarrhea, constipation;
intestinal colic;
decreased appetite;
anorexia;
taste disturbance;
dry mouth;
headache;
dizziness;
increased excitability, irritability, depression;
sleep disturbance, drowsiness;
hallucinations;
convulsions;
urinary incontinence;
red-brown coloring of urine;
excessive development of vaginal fungal flora (including vaginal candidiasis);
skin rash, itching, urticaria;
arthralgia;
leukopenia, agranulocytosis, neutropenia, thrombocytopenia;
pustular rashes.

Contraindications

leukopenia (including history);
organic lesions of the central nervous system (including epilepsy);
liver failure (if the drug is prescribed in high doses);
1st trimester of pregnancy;
lactation period (breastfeeding);
children under 3 years of age;
hypersensitivity to metronidazole or other nitroimidazole derivatives.

Use during pregnancy and breastfeeding

Metronidazole penetrates the placental barrier, therefore Trichopolum is contraindicated for use in the 1st trimester of pregnancy. The use of the drug in the 2nd and 3rd trimesters is possible only in cases where the expected benefit to the mother outweighs the potential risk to the fetus.

Since metronidazole is released with breast milk, reaching concentrations in it close to the concentration in the blood plasma, if it is necessary to use Trichopolum during lactation, breastfeeding should be stopped.

Special instructions

Trichopolum should be prescribed with caution to patients with severe liver failure, because as a result of a slowdown in metabolism, the concentration of metronidazole and its metabolites in plasma increases.

Caution is required when prescribing Trichopolum to patients with suppression of bone marrow hematopoiesis and central nervous system functions, as well as elderly patients. The appearance of ataxia, dizziness and any other deterioration in the neurological status of patients requires cessation of treatment.

During long-term therapy with metronidazole (more than 10 days), peripheral blood patterns and liver function should be monitored.

With leukopenia, the possibility of continuing treatment depends on the risk of developing an infectious process.

The use of metronidazole should be avoided in patients with porphyria.

When treating trichomonas vaginitis in women and trichomonas urethritis in men, it is necessary to abstain from sexual activity. Simultaneous treatment of sexual partners is mandatory. After treatment for trichomoniasis, control tests should be carried out during three consecutive cycles before and after menstruation.

After treatment of giardiasis, if symptoms persist, after 3-4 weeks it is necessary to conduct 3 stool tests at intervals of several days (in some successfully treated patients, lactose intolerance caused by infestation may persist for several weeks or months, resembling the symptoms of giardiasis).

Patients should refrain from drinking alcohol during therapy with metronidazole, as well as for at least 48 hours after completion of treatment, due to the possibility of developing disulfiram-like reactions: cramping abdominal pain, nausea, vomiting, headache, sudden flushing of blood. face.

During treatment with metronidazole, urine may become dark or red-brown in color due to the presence of water-soluble dyes.

Trichopolum can cause immobilization of treponemes, which leads to a false-positive Nelson test.

Use in pediatrics

Impact on the ability to drive vehicles and operate machinery

When taking the drug, you should avoid potentially dangerous activities that require increased concentration and speed of psychomotor reactions, especially driving. vehicles and maintenance of mechanisms.

Drug interactions

Metronidazole enhances the effect of warfarin and other coumarin anticoagulants (with this combination, a reduction in the doses of both drugs is required).

Cimetidine inhibits the metabolism of metronidazole, which can lead to an increase in its concentration in the blood plasma and an increased risk of adverse reactions.

In patients receiving long-term treatment with lithium drugs in high doses, when taking Trichopolum, it is possible to increase the concentration of lithium in the blood plasma and develop symptoms of intoxication.

When taking Trichopolum and cyclosporine in combination, an increase in the concentration of cyclosporine in the blood plasma may be observed.

Metronidazole reduces the clearance of fluorouracil, which may increase the toxicity of the latter.

When used concomitantly, metronidazole may increase plasma concentrations of bisulfan.

Sulfonamides enhance the antimicrobial effect of metronidazole.

Similarly to disulfiram, Trichopolum causes ethanol (alcohol) intolerance. The simultaneous use of Trichopolum with disulfiram can lead to the development of various neurological symptoms (the interval between the use of these drugs should be at least 2 weeks).

Analogues of the drug Trichopolum

Structural analogues of the active substance:

Batsimex;
Deflamon;
Klion;
Metrovagin;
Metrogil;
Metroxan;
Metrolacare;
Metron;
Metronidazole;
Metronidazole Nycomed;
Metronidazole-AKOS;
Metronidazole-Altpharm;
Metronidazole-UBF;
Metronidazole-ESCOM;
Metronidal;
Metroseptol;
Orvagil;
Rosamet;
Rosex;
Cyptrogyl;
Trichobrol;
Trichosept;
Flagyl;
Efloran.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.

Trichopolum is a highly effective antimicrobial drug. This has made it popular among doctors of various specialties who use the product in their practical activities. At the same time, the pharmaceutical market offers patients a large number of analogues of this drug. They all differ significantly - in price, appearance packaging, release form, country of origin. But active substance They have the same thing - metronidazole.

Are there any significant differences between the means? Is it possible to replace one drug with another of similar composition? Will the analogue be as effective? About this we'll talk in today's article.

Trichopolum is an antimicrobial medicine that is active against protozoa - Trichomonas, Gardnerella, Giardia. In addition, the product is used to treat diseases caused by obligate anaerobic microorganisms.

Trichopolum is an antiprotozoal drug with an antimicrobial effect

The main ones include:

clostridia;
peptococci;
peptostreptococci;
bacteroides;
fusobacteria;
Veillonella.

The active ingredient is metronidazole. It interacts with the DNA of pathogenic microorganisms, inhibiting its synthesis. This causes the death of pathogens.

Trichopolum is quickly absorbed into gastrointestinal tract patient. The maximum concentration in the blood is observed within two hours after administration. The drug penetrates well into all tissues and biological fluids, including breast milk. 80% of the drug is excreted in the urine, the rest in feces. U healthy person the half-life is 8 hours. In case of liver pathology, which is accompanied by functional failure of the organ, this period increases. Trichopolum is also used in the form vaginal tablets, exerting a local effect on the body.

In general, Trichopolum is well tolerated. From side effects the most common symptoms are nausea, dizziness, allergic reactions, and digestive tract. The drug should not be used to treat pregnant women and during lactation, as well as patients with liver failure.

Domestic analogues

The most common analogue of trichopolum is metronidazole. It is produced at numerous pharmaceutical factories in our country.

The main forms of release include tablets and injection solution. One metronidazole tablet may contain 250 or 500 mg of active ingredient. One bottle contains 100 ml of 0.5% solution for injection. That is, each milliliter of the drug contains 5 mg of metronidazole.

Metronidazole is a cheaper analogue expensive drug Trichopolum

The drug has optimal pharmacokinetic properties. Its bioavailability, that is, the ability to reach the site of the disease, ranges from 80 to 100% compared to the concentration of the drug in the blood plasma. In the cerebrospinal fluid this figure is slightly lower. This allows the use of tablet forms of the product. Injectable forms are used only in cases of severe illness.

Like Trichopolum, metronidazole penetrates well into all fluids and tissues of the body, reaching its maximum concentration within 2 hours after administration. The half-life ranges from 6 to 10 hours. It increases in patients with liver failure. The drug freely passes through the hematoplacental and blood-brain barrier.

Foreign analogues

The most popular foreign analogues of Trichopolum include:

Flagyl;
Metrogil;
Klion;
Metroxan;
Deflamon.

Flagyl is a more expensive analogue of French-made Trichopolum

Flagyl is an original drug manufactured in France. This is the most expensive of all drugs containing metronidazole. Metrogyl - produced in India. Relatively low cost, combined with good tolerability and high efficiency, made this product one of the most popular analogues original drug. Klion is also a highly effective medicine. Produced in Hungary. Metroxan is another one French drug. Deflamon is produced in Italy.

Like Trichopolum, all these drugs penetrate well into all organs and tissues of the body, reaching bactericidal concentrations where it is required.

Klion D belongs to the antiprotozoal drugs

Like Trichopolum, its foreign analogues are available in the form of tablets and solutions for injection. In addition, foreign companies produce local forms of the drug. These include:

vaginal suppositories;
vaginal tablets;
vaginal gel;
cream and gel for external use.

Metrogyl - vaginal gel

Thanks to their local effect, they have a detrimental effect on the pathogen where it is needed most. At the same time overall impact on the body is minimal, as is the risk of side effects.

Advantages and Disadvantages

Despite the fact that the active substance of the drugs is the same, it cannot be said with certainty that they all have absolutely the same effect on human body. Each of the analogues has its own advantages and disadvantages.

Domestic products differ from Trichopolum in their rather low cost. In some cases it can be 10 times lower. But this does not mean at all that regular metronidazole will be less effective than imported one.

Among the shortcomings domestic drugs You can highlight the very bitter taste of the tablets and the not very aesthetic packaging. The last fact is one of those that explains low cost domestic medicines.

All foreign-made analogues are distinguished, first of all, by their high price. This is their main disadvantage. For this reason, they are relatively rarely prescribed by domestic doctors, who, among other things, take into account the financial capabilities of patients.

Analogue drugs are similar in indications for use and their pharmacological action

The advantage of foreign medicines is the presence of a shell on the tablets. This reduces the patient's taste sensation, but significantly increases the cost. In addition, practicing doctors tend to believe that foreign-made drugs are much better tolerated by patients. They explain it more perfect production process and a high degree of purification of the active substance.

Another advantage foreign analogues– availability local forms. Thanks to them, there is no need to prescribe pills to a patient with colpitis. Instead, doctors recommend vaginal suppositories and gel. Cream and gel for external use are used for treatment acne in adolescents, rosacea, fissures anus, wounds, bedsores, trophic ulcers.

Final decision on appointment medicinal drug is taken by the attending physician. Only he can take into account all the subtleties and make right choice. Changing the drug yourself can lead to a lot of undesirable effects. Unsatisfactory treatment results are one of them. If the patient has any doubts or questions, he should discuss them with the doctor. This will allow you to get good result to the maximum short terms, with the least risk of side effects.

Pharmacological action

Antiprotozoal drug with antibacterial activity for local application in gynecology. Refers to nitro-5-imidazoles. The mechanism of action of metronidazole is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole interacts with the DNA of microbial cells, inhibiting the synthesis of their nucleic acids, which leads to the death of microorganisms.

Metronidazole is an effective antimicrobial and antiprotozoal agent wide range actions. Shows high activity against Trichomonas vaginalis, Gardnerella vaginalis, Giardia intestinalis, Entamoeba histolytica, Lamblia spp., as well as for obligate anaerobes - Bacteroides spp. (Bacteroides fragilis, Bacteroides ovatus, Bacteroides distasonis, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonella spp., Prevotella spp. (Prevotella bivia, Prevotella buccae, Prevotella disiens) and some gram-positive microorganisms (Clostridium spp., Peptostreptococcus spp., Peptococcuc spp., Eubacterium spp., Mobiluncus spp.).

Pharmacokinetics

Metronidazole is well absorbed when administered intravaginally. Biotransformed in the liver. It is excreted 40-70% (about 20% in unchanged form) by the kidneys.

Indications

For local treatment:

- nonspecific vaginitis;

- bacterial vaginosis;

- Trichomonas vaginitis.

Dosage regimen

At trichomonas vaginitis the drug is prescribed 1 vaginal tablet per day for 7-10 days in combination with taking the drug metronidazole tablets.

At nonspecific vaginitis, bacterial vaginosis the drug is prescribed 1 vaginal tablet per day for 7 days, if necessary in combination with taking metronidazole tablets.

Treatment with metronidazole should not last more than 10 days and be repeated more than 2-3 times a year.

The vaginal tablet should be removed from the contour packaging, moistened with boiled cooled water and inserted deep into the vagina.

Side effect

Local reactions: itching, burning, pain and irritation in the vagina; thick, white, mucous vaginal discharge (odorless or faint odor), frequent urination; after discontinuation of the drug - development of vaginal candidiasis.

From the digestive system: nausea, change taste sensations, metallic taste in the mouth, dry mouth, loss of appetite, cramping pain in abdominal cavity, nausea, vomiting, constipation or diarrhea.

From the side of the central nervous system: headache, dizziness.

From the hematopoietic system: leukopenia or leukocytosis.

Allergic reactions: hives, itchy skin, rash.

Other: rarely - red-brown coloring of urine due to the presence of a water-soluble pigment formed as a result of the metabolism of metronidazole; a burning sensation or irritation of the penis in a sexual partner.

Contraindications for use

- blood diseases;

— leukopenia (including history);

- impaired coordination of movements;

— organic lesions of the central nervous system (including epilepsy);

- liver failure (for use in high doses);

— pregnancy (first trimester);

- lactation (breastfeeding);

- hypersensitivity to metronidazole or other nitroimidazole derivatives.

Use during pregnancy and breastfeeding

Metronidazole passes through the placenta, so the drug should not be prescribed in the first trimester of pregnancy. In the future, the drug should be used only if potential benefit for mother exceeds possible risk for the fetus.

Metronidazole is excreted in breast milk. Breastfeeding should be discontinued during the period of use of the drug. Breastfeeding should be resumed no earlier than 48 hours after stopping the drug.

Use in children

Safety of use infusion solution Trichopolum children under 5 years of age not installed.

Overdose

Data on overdose of the drug Trichopol ® are not provided.

Drug interactions

The drug is compatible with sulfonamides and antibiotics.

Metronidazole causes ethanol intolerance, so alcohol should be avoided during treatment.

You should not combine metronidazole with disulfiram, since the interaction of these drugs may cause depression of consciousness and the development of mental disorders.

When used simultaneously with indirect anticoagulants(including warfarin) metronidazole enhances their effect, which leads to an increase in prothrombin time.

Under the influence of barbiturates, the effectiveness of metronidazole may decrease due to acceleration of its metabolism in the liver.

Cimetidine inhibits the metabolism of metronidazole, which can lead to an increase in its concentration in the blood plasma and an increased risk of adverse reactions.

When taken simultaneously with lithium preparations, it is possible to increase its concentration in the blood plasma.

Conditions for dispensing from pharmacies

The drug is available with a prescription.

Storage conditions and periods

The drug should be stored in a dry place, protected from light and out of reach of children, at a temperature not exceeding 25°C. Shelf life – 3 years.

Use for liver dysfunction

Contraindicated in liver failure(for use in high doses).

Use for renal impairment

WITH caution the drug should be prescribed to patients with renal failure.

In case of severe renal failure (creatinine clearance less than 10 ml/min) The daily dose of Trichopolum should be reduced by 2 times.

Use in elderly patients

In elderly patients, renal excretion of metronidazole is reduced.

If there is a history of changes in the composition of peripheral blood, as well as when using the drug in high doses and/or long-term treatment control needed general analysis blood.

Metronidazole can cause immobilization of treponemes, which leads to false positive results Nelson test (TPI).

Impact on the ability to drive vehicles and operate machinery

The possibility of dizziness should be taken into account when prescribing the drug to patients involved in potentially dangerous species activities (especially vehicle drivers).

Today, pharmacological production is thriving, so improved drugs, as well as their analogues, are regularly released for sale. They are made from identical active ingredients and have different manufacturers, therefore they have low cost. This is precisely why analogues of expensive drugs attract medical staff and consumer mass. To find out which analogue of Trichopolum is better, let’s figure out what the original Trichopolum is.

Trichopolum– a medicinal product intended to destroy microbes and protozoa: Giardia, Trichomonas, Gardnerella. Also, this remedy highly effective against anaerobic microorganisms.

General characteristics of Trichopolum

As mentioned earlier, Trichopolum - antimicrobial agent related to antiprotozoans medicines. It is made on the basis of Metronidazole, which is widely used to treat helminth infestations, destroy microorganisms and anaerobic bacteria:

Vionell.
Clostridium.
Fusobacterium.
Peptococcus.
Bacteroid.
Peptostreptococcus.

When the active substance Trichopolum enters the body of an infected person, it affects the genetic system of microorganisms, blocking their synthesis and leading to death.

Trichopolum is available in tablet form intended for oral use. Therefore, after taking medicine, the tablet penetrates digestive system and begins to fight the pathogen. 2 hours after application, Trichopolum is distributed to:

Fabrics.
Organs.
Systems of the human body.
Biological fluids.
Concentrated in the blood.

8 hours after using Trichopolum, the tablets are excreted from the body by the urinary system (80%), and together with feces (20%).

Also, Trichopolum is available in the form of vaginal tablets. They are designed to destroy microorganisms in women's reproductive system. The principle of action of vaginal tablets is similar to oral use. However, in this case, the bulk of metronidazole is not distributed throughout the body, but remains in the area of the internal genital organs.

Side effects

Allergies.
Diarrhea or constipation.
Dizziness.
Headaches.
Nausea.

When prescribing Trichopolum to patients, no one knows whether the infected person will have an allergic reaction. Therefore, it is recommended to use cheaper analogues of this drug for treatment.

Contraindications to the use of Trichopolum

Considering the scale of the impact and the route of distribution of the drug throughout the body, Trichopolum is prohibited for patients under the following circumstances:

During pregnancy.
Lactation.
Kidney failure (they may not be able to remove the drug from the body).

Hence, this drug it is strictly prohibited to use in for preventive purposes, and also without appointment as a specialist.

Existing similar drugs

Today, many analogues of Trichopolum are supplied to pharmacies. They are divided into:

Domestic.
Foreign.

Both categories of these drugs are widely used in medicine, but the latter have a much higher cost. Let's take a closer look at the most common medications included in these groups.

Analogs of domestic origin

The most common analogue of Trichopolum in Russia and surrounding countries is the drug Metronidazole.

It is available in 2 forms:

Tablets (200 mg or 500 mg of metronidazole in 1 pill).
Solution for injection (0.5% metronidazole solution in 1 bottle, volume 100 ml.).

Most often, in medicinal purposes use tablets. They are able to reach the lesion by 80-100%. Solutions for injections, used exclusively for inpatient conditions, at severe forms infection.

The process of action of Metronidazole on protozoa, bacteria and microorganisms is similar to Trichopolum. It easily overcomes the blood-brain and hematoplacental barrier, and then spreads throughout the body, its fluids and is excreted within 6-10 hours (depending on the patient’s condition). In case of kidney disease, the medicine is excreted slowly.

Foreign analogues of Trichopolum

Foreign drugs have also confirmed their effectiveness: Flagyl and Metroxan (France), Metrogyl (India), Klion (Hungary), Deflamon (Italy). They are made on the basis of Metronidazole, are well tolerated and high level efficiency. However, compared to their domestic counterpart, they are expensive.

Considering that Trichopolum and its analogues are made from the same active substance, they work in the same way, destroying microorganisms in those places where it is needed.

Klion D

Klion D is an antiprotozoal drug that has an extended release form. It can be bought in pharmacies, in the form of an injection solution and tablets, like other Trichopolum analogues. Also available for free sale:

Gel and cream for external treatment.
Vaginal suppositories.
Vaginal gel.
Vaginal tablets.

These measures make it possible to provide local therapy, reducing the risk of negative consequences and deterioration general well-being person.

Advantages and disadvantages of Trichopolum analogues

Despite the fact that foreign and domestic analogues Trichopolum is identical in its properties, penetrating into the body, they may differ slightly. Let's consider what advantages and disadvantages these drugs have:

Advantages.

Flaws.

Domestic.

Are the cheapest antiprotozoal drugs. However, the result of treatment with them is similar to expensive medicines.

Does not have a gelatin shell, therefore, when consumed, a person feels bad taste bitterness.

The tablets are packaged in regular, non-colorful packaging.

Foreign.

Have a shell, therefore they are easy to use and do not provoke an unpleasant aftertaste.

Well tolerated by patients. According to doctors, improved equipment is available abroad that makes it possible to better purify the components of the drug. And as a result, the risk of side effects is significantly reduced.

The latest development is an analogue of Trichopolum, in the form of an ointment or gel makes it possible to get rid of not only microorganisms, but also teenage acne, wounds, trophic ulcers, bedsores, rosacea, anal fissures.

Are expensive. For this reason, not every patient will be able to use the Trichopolum analogue for medicinal purposes.