Dioxidin instructions for use compress. Dioxidin is a “heavy” drug that is often prescribed to children. Is it worth the risk or is it better to look for an alternative...

Dioxidin is often used for washing wounds and intracavitary administration - instructions for using this antibacterial agent from very dangerous microorganisms and pathogens (resistant staphylococci, Pseudomonas aeruginosa, salmonella and anaerobic bacteria) will explain how to use the remedy for inflammation, which choice of form is correct - in the form of an ointment (3%) or a solution in an ampoule (0.5 or 1%).

Dioxidin - application

The drug is often prescribed as the main aid for purulent processes, wounds, burns to treat the affected area. Dioxidin is also indicated for rinsing internal cavities: peritonitis (in the peritoneum), pleurisy, lung abscesses and inflammation between the membranes of the main respiratory organs. The product will cope with dysentery and Klebsiella bacilli, Pseudomonas aeruginosa and other bacteria. The drug is not prescribed to children under 12 years of age; it is optimal not to use Dioxidin under 18 years of age.

There are options for using the composition to relieve chronic runny nose, sinusitis, and otitis caused by bacteria resistant to other antibiotics. The product will provide not only cleansing of the burned surface when rinsing, but also tissue regeneration. The product is effective even against pathogens resistant to the latest 4th generation drugs. Pharmacies offer different shapes tools for various tasks:

Ampoules with a one percent solution are used for rinsing (no more than 70 ml/day).
Three percent ointment should be applied under a bandage to the affected surface only 1 time/day.
Dioxidin is dripped into the nose of children three times a day, drop by drop - to prevent more serious diseases, in case of chronic inflammatory process. This measure helps to avoid complications of rhinitis, however, pediatricians often select more gentle remedies.
For chronic runny nose caused by antibiotic-resistant bacteria, it is permissible to drip Dioxidin into the nose of an adult instead of standard vasoconstrictors. The dosage is almost the same. There is no special packaging of the drug for nasal use.
Other indications are empyema of the gallbladder, cystitis, preventive measures against infectious complications.

Compound

Basics active substance– Dioxidin is essentially a poison, so it is used with caution. Ampoules contain hydroxymethylquinoxaline dioxide (10 mg/ml, each 100 mg), among excipients– water for injection only. The ointment contains:

main substance – 5 g;
polyethylene oxide 400 and 1500 – 74.9 and 20 g each;
nipagin – 0.08 g
propyl ester of acid (parahydroxybenzoic) – 0.02 g.

Release form

Please note: there is no special bottle for nasal use, because... the introduction of agents against pathogenic microflora is very limited. The main forms are liquids and ointments of different percentages, and the ratio is as follows:

in ampoules – 0.5 and 1%, 5 and 10 pcs.;
in ointment - 5% of the substance, in tubes of 30 or 50 grams.

Pharmacodynamics and pharmacokinetics

Hydroxymethylquinoxaline dioxide destroys the membrane cells of pathogens. However, it does not act this way on all microorganisms, so ideally a bacterial culture is needed to determine their sensitivity to the antibiotic. Otherwise, the use of Dioxidin will not be justified. Regarding children's reception, then it is important to know: the drug can damage the villi of the mucous membrane, so it is better to avoid injecting it into the nose or wiping it with a cotton pad soaked in the substance. On wounds, the drug is partially absorbed by body cells, but is well excreted by the kidneys.

Indications for use

The main indications for use include all types of burns, rotting wounds and abscesses. In this case, even pathogenic flora resistant to conventional antibiotics is destroyed. However, there are nuances:

the product is used for abscesses in the abdominal cavity, lungs, pleura - up to 70 ml/day;
the ointment is applied to the affected surfaces in a thin layer once a day;
to rinse the nasal sinuses in children, only a 0.5% solution is used, or the substance from an ampoule with a 1% composition is diluted with water in half (in equal proportions);
in severe sepsis and severe inflammation, the presence of microbes in the blood, it is permissible to use a 0.5% solution intravenously - diluting it in 5% glucose or sodium chloride (isotonic solution) - in a concentration of up to 0.1-0.2%.

Contraindications

During pregnancy, use is limited, as well as for kidney problems and bladder when the dose is reduced. In addition, there are clear contraindications for the product. This:

insufficient functioning of the adrenal glands;
individual intolerance;
childhood(up to 18 years old).

Directions for use and dosage

There are several options for using the substance. The drug is prescribed only to adults. After the tolerance test, 10 milliliters of solution (1%) are supplied to the cavities. Reactions to the substance are monitored; their absence within 6 hours will indicate that the composition can be used as a course, otherwise Dioxidin will not be prescribed. Other options:

A drainage tube is taken, which is used to drain pus or blood, a syringe or catheter - 10-50 ml of solution is injected at a time.
For osteomyelitis, apply the product to purulent wounds in the amount of 15-20 drops per minute, using Dioxidin in the same mode for 1-2 hours, in severe cases - up to half a day.
To rinse the nose of children or introduce it into the ear canal, a 1% solution must be diluted with the same amount boiled water or use 0.5%.

Special instructions

When stored at temperatures below 15 degrees, sediment (crystals) may form in the ampoules - they can be dissolved by heating in a water bath, shaking occasionally. If, after cooling to a temperature of 36-38 degrees, the crystals do not fall out again, the drug is considered normal and acceptable for use. Special attention is also paid to side effects and further treatment. The following nuances are taken into account:

Antihistamines (antiallergic) drugs can reduce negative manifestations.
To compensate for the effects of the antibiotic, calcium is prescribed.
If spots on the skin are detected (due to photosensitivity), the dose is reduced.

During pregnancy

Dioxidin is prescribed during pregnancy only if other prescriptions are ineffective, and the result will be more significant than the harm from its use. The danger of the product lies in its action:

teratogenic (development of defects and deformities);
embryotoxic (toxicity causes functional, structural damage the child’s body, incl. and after birth);
and then - into breast milk (natural feeding is suspended while taking the medicine).

Dioxidin for children

The use of the product for children is of dubious benefit. It is rarely prescribed by pediatricians. There is an opinion that it is possible to rinse the nasal passages, but this is only reasonable in case of severe chronic inflammation and the absence of bacterial response to other, more traditional antibiotics. At the same time, it is taken into account that the child can swallow the substance, and when instilled, an unpleasant bitter taste is felt. How to drip Dioxidin into a child’s nose correctly:

Do not allow the product to enter the gastrointestinal tract.
Invite your child to hold his breath.
Tilt his head and inject the product with a syringe or syringe without a tip.
If necessary, combine drops with hydrocortisone (to relieve swelling, remove allergic manifestations), adrenaline (vasoconstrictor), water for injection, diluted sodium chloride - to change the percentage of the substance and ease of irrigation.
Please note that the normal prescription of Dioxidin by pediatricians under the age of 12 years is extremely limited (diluted 1 to 1 with water).

Interactions with drugs

Interactions with other drugs have not been described, and there is no prohibition on their use. However, they additionally give:

Calcium preparations – as an antiallergic agent.
Antihistamines.
Hydrocortisone as an anti-inflammatory for sinusitis, severe congestion paranasal sinuses.

Side effects

When taking the drug, side effects are taken into account. Among them are headache and chills. Still possible:

allergic manifestations;
photosensitivity (pigmented sun spots);
nausea, diarrhea, vomiting;
periwound dermatitis (skin irritation);
increase in temperature;
convulsions.

Dioxidin is a domestically produced drug that was widely used in the USSR. Due to its strong toxic effects and side effects described in the instructions, use is recommended in extremely severe cases.

Dioxidine (Hydroxymethylquinoxylin dioxide) – medicine with antibacterial effect. Chemical formula C10H10N2O4. Refers to local antibiotics. It has high bactericidal properties and resistance to other types of antibiotics.

Active regarding various types bacteria, pathogenic anaerobes. Capable of influencing bacterial species that are resistant to other drugs.

Release form and composition

Produced in the form:

Ointment for external use 5%, which is sold in tubes weighing 30 and 40 g;
1% solution for infusion and external use. It is found in glass ampoules with high chemical resistance, which are packaged in a special material made of foil or paper. If there is no break point on the glass jar, a knife for opening is included;

A 1% solution for internal use, which is also applicable in the treatment of superficial lesions. Packaged in glass containers 5, 10 ml. Available in a cardboard box.

Pharmacological action

The instructions for use indicate: Dioxidin is an antibacterial medicine. Calls out strong structural changes in the cytoplasm of microorganisms. Has chemotherapeutic activity for various infections.

The drug is used when working with various injuries bodies. Its use in this case causes rapid cleaning of wounds and accelerates their regeneration. All this has a beneficial effect on the overall progress of healing.

Pharmacodynamics and pharmacokinetics

The drug is used for infections caused by:

Klebsiella (Klebsiella pneumonia, Klebsiella oxytoca, etc.);
coli;
salmonella;
staphylococci and streptococci;
pathogenic anaerobes.

The pharmacokinetics of this drug have been poorly studied. When administered internally, it penetrates well into various tissues of the body. It is also well absorbed when applied externally and introduced into the cavity. Dioxidin is excreted through the kidneys, but there is no accumulation in the body.

Indications for use of Dioxidin

When used externally, Dioxidin is effective for:

damage to body tissues various types heaviness;
injuries that are difficult to treat;
acute purulent inflammation of tissues;
infected burns;
osteomyelitis.

Internal use is effective for:

intracavitary purulent diseases;
inflammation pleural layers and empyemas, purulent destructive formations in the lungs, cystitis and peritonitis;
severe runny nose in a prolonged form when other therapy is ineffective.

Contraindications

The use of Dioxidin is excluded in the following cases:

Side effects

When using Dioxidin, the following side effects may occur:

periwound inflammation;
headache;
chills;
increase in temperature;
allergy;
involuntary muscle contractions;
nausea and vomiting;

Application of Dioxidin in ampoules

Nasal drops:

prolonged runny nose;
ineffectiveness of other therapy;
the appearance of an unpleasant odor and color in the discharge.

Liquid for inhalation by nebulizer:

lung abscesses;
severe inflammation of the bronchi;
sinusitis and sinusitis;
empyema of the pleura.

Form of direct use at the source of infection:

pneumonia;
cystitis;
tissue inflammation;
infectious diseases in the chest and abdominal cavities.

Application of Dioxidin in solution

Complex drops;
Intravenous drip:

meningitis;
purulent infection with rapid spread;
prevention of postoperative complications;

Compresses and applications:

therapy for non-healing long period time of wounds and ulcers;
severe consequences varicose veins;
diabetic angiopathy with complications.

Use of Dioxidin in the form of ointment

Trituration:

moderate and severe superficial wounds;
bedsores.

Tamponation:

severe deep wounds;
high severity burns.

External use of Dioxidin

According to the instructions, it is recommended to use Dioxidin on thermal skin damage (burns) and wounds of varying severity:

when treating infected wounds with purulent formations, apply gauze soaked in Dioxidin (0.5-1%);
deep body injuries are tamponed with 1%;
for osteomyelitis, baths are made from the drug (0.5-1%), or it is injected into the lesion for up to 20 minutes, followed by application of a napkin with Dioxidin 1%;
after surgery to prevent infections. A product containing 0.1-0.5% Hydroxymethylquinoxyline dioxide copes with this.

Use of Dioxidin intracavity

The drug is used in the treatment of intracavitary purulent formations. To do this, 10-50 ml of Dioxidine 1% is injected daily into the required area (based on the size of the damage).

This is done using a syringe or catheter, and a drainage tube is also used. The patient receives the daily share 1, less often 2 times. The absence of side effects allows you to use Dioxidin for up to 3 weeks.

The maximum daily administration should not exceed 70 ml. Repeated courses of drug administration can be prescribed after 1 or 1.5 months.

Use of Dioxidin intravenously

The drug is used intravenously for severe inflammatory conditions, purulent meningitis and severe purulent-inflammatory reactions in the body.

The drug is administered slowly by drop method in 3 or 4 procedures. The daily dose should not be higher than 900 mg (as prescribed by a doctor in extremely severe cases, it increases to 1200 mg) of the drug. A solution is prepared by mixing the drug 0.5% with glucose 5%. The concentration of the active component in the finished solution should be in the range of 0.1-0.2%.

Use of Dioxidin for children

When using Dioxidin for a child, the instructions for use must be studied completely. The drug is prescribed to children only in severe cases when other medications do not have the desired effect.

It is used for chronic purulent processes, prolonged runny nose, severe infections, otitis media:

Dioxidin is used as nasal drops. To do this, the drug is injected into the nasal passage, 2 drops 2 times a day;

It is possible to use the drug as inhalation. It is used to eliminate severe wet cough. To do this, Dioxidin 0.5% is mixed in a 1:2 ratio with saline solution. The drug 1% is diluted as 1:4.

Use of Dioxidin during pregnancy and lactation

Due to its strong toxicity and negative impact on the fetus, the drug is not recommended for pregnant women. Exceptional cases may be severe consequences of a runny nose or sinusitis.

In these situations, the drug is prescribed locally (drops, inhalation) in reduced concentrations:

Place 5 drops in the nose 3 times a day;
In the ear, the recommended dosage is 0.5 g per day, 2 times;
Dioxidin 0.5% is used as inhalation in a 1:2 ratio with saline solution.

More than 8 mg of the drug per day is prohibited.

Nebulizer use

Inhalation with a nebulizer using Dioxidin is used for sinusitis, sore throat, pharyngitis and laryngitis. The solution is prepared as follows: 2 ml of the drug 0.5% to 4 ml of saline solution. The procedure is carried out for 2-3 minutes, followed by an increase to 5-7 minutes. Inhalation is repeated every day for 7 days.

Instructions for ear treatment

Used when purulent otitis when other drugs do not give the desired effect. It is necessary to drip into a completely clean ear canal. For children, a 0.5% solution is taken, which is diluted with a hypertonic solution to a concentration of 0.2%. Instill 1-2 drops 2 times a day.

Dioxidin, instructions for use allow you to use the drug as ear drops

For adults, the dosage is increased to 3 drops. Treatment should not exceed 7 days.

Instructions for treating a throat

Instructions for use of the drug describe the use of Dioxidin for pharyngitis, tonsillitis, severe purulent and inflammatory processes of the throat. The concentration of the drug in the solution must be selected based on the severity of the disease. So, for purulent tonsillitis, 1 ampoule of the drug is diluted with Miramistin 0.1% in a glass of heated water. The throat is washed up to 4 times a day.

There is another way to treat a throat: hydrogen peroxide (2 tablespoons) is added to Dioxidin with Miramistin, which is separately diluted with warm water. The procedure in this case is done by gargling in pairs with these solutions (1 sip of each) 3 times a day.

Instructions for treating the nose

The drug is prescribed only for such diseases and symptoms as: acute inflammation, persistent runny nose, mucus discharge unpleasant smell and color, severe sinusitis.

For drops, Dioxidin 0.5% is used, diluted with hydrocortisone, adrenaline or sodium chloride with water. As a result, the concentration of Dioxidin should be 0.1-0.2%. In this form, the drug is administered 2-3 drops into each sinus 3-5 times a day. With normal tolerability, the duration of treatment with the drug reaches 4-5 weeks.

For children, the drug is rarely used, starting from the age of 12 years. Its use is justified only in severe forms of the disease. In this case, Dioxidin is diluted in a concentration of 1:2.

Instructions for the treatment of bronchi

The drug is prescribed for inflammatory pathologies of the respiratory tract (bronchitis, tracheitis). It is used in inhalation form to relieve symptoms.

For this, Dioxidin 0.5-1% in ampoules is used. It is diluted with saline 1:2 (at 0.5%) or 1:4 (at 1%). For adults, inhalation is carried out starting from 3 minutes and increasing to 5-7 minutes. The intensity of use is 1 time per day. Treatment duration should not exceed 7 days.

Children's inhalation is possible only if the effectiveness of other less toxic agents is weak. To do this, take the drug 0.5% and mix it with saline solution 1:4. The volume of the active substance should not exceed 2 ml per 1 procedure; the dosage depends on the child’s age and weight.

Instructions for treating wound surfaces

Externally, the product is used in the presence of superficial wounds of varying concentrations, trophic ulcers, burns, and wounds with osteomyelitis.

Used as ointment and liquid:

For superficial wounds, apply a napkin with Dioxidin 1%;

For deep wounds, additional tamponing of the required area is carried out using Dioxidin 1%;
In severe cases of osteomyelitis, baths with a solution of the drug are prescribed (for 20 minutes) with further application of napkins to the affected area.

Overdose

Overdose (poor tolerance) of this drug is a source of:

Acute adrenal insufficiency. If this symptom occurs, immediate discontinuation of Dioxidin and administration of hormone therapy is necessary;
Peri-wound dermatitis. This symptom requires a reduction in the amount of the drug taken or replacement with a more tolerable similar drug;
Anaphylactic shock. In this case, it is necessary to immediately stop taking the drug and carry out a set of measures to treat the patient;
Photosensitizing effect. This symptom requires a reduction in the dosage of the drug or replacement with a similar one;
Nausea and vomiting. If this symptom occurs, it is necessary to stop taking the drug and carry out a set of measures aimed at removing Dioxidin.

Compatibility with other drugs:

With the simultaneous use of Streptomycin, Monomycin, Gentamicin, an increase in the effect of both drugs is observed.

Antihistamines paired with Dioxidin have good compatibility, however, they are not recommended to be used simultaneously for acute sinusitis.

Naphthyzine, Dexamethasone together with Dioxidin lead to an increased effect of the drugs.

The saline solution serves to reduce the concentration of Hydroxymethylquinoxyline dioxide without changing the properties of the drug.

Storage conditions and periods

Dioxidine should be kept in its original packaging in a dark place out of the reach of children. An open ampoule is used within 24 hours. The appearance of sediment is considered normal occurrence , to eliminate it, you need to heat the solution. The period of use is 2 years.

Analogs

Dioxidin analogues include all drugs with the active component Hydroxymethylquinoxyline dioxide. These include: Dioxysept, Diquinoxide, Urotravenol.

Doctors' opinions

For a child, it is preferable to prescribe another, less toxic drug;
Dioxidin is not highly addictive. This is a drug that does not have a vasoconstrictor effect, but an antibacterial effect;
In work they are often prescribed for otitis media, after middle ear surgery;
I have been using the drug in practice for a long time. Based on the experience of using the drug, it is noticeably superior to Levomekol and copes well with infected wounds. I wash the wound cavities with Dioxidin solution. The drug is highly effective.

Dioxidine price

Examples of drug prices in Russia:

	Minimum cost	Maximum cost	Average cost
Solution 1% 10 ml	49	432	240
Ointment 5% 30g	240	449	345
Ampoules 0.5% 5ml	41	396	219

It is necessary to use Dioxidin only with the permission of a doctor, strictly following his instructions for use. Self-medication due to the strong toxicity of the active substance is extremely dangerous for the body with harmful consequences.

Video about Dioxidin

Use of Dioxidin for hidradenitis:

Using the drug in a nebulizer:

Dioxidin ® is a synthetic antibiotic that is a derivative of quinoxaline. Has a number specific features, which determine the scope of its application in medical practice. It exhibits the greatest bactericidal activity under anaerobic conditions, destroying all the most common types of pathogens of purulent infection.

It is usually used in a hospital setting for the treatment of septic conditions, as it is a reserve antibacterial drug. Its effectiveness is combined with high toxicity, so the drug is prescribed only if treatment with other, less toxic antibiotics fails.

The drug has been used in medicine for several decades and has proven itself as antimicrobial agent wide spectrum of action. The most sensitive to it are Proteus, many varieties of Klebsiella, and Escherichia coli, pseudomonas, staphylococci and streptococci, salmonella (especially insensitive to other groups of antibiotics). Resistance to it in bacteria develops quite slowly.

The active ingredient – hydroxymethylquinoxylin dioxide – destroys pathogenic microorganisms due to penetration into them and blocking DNA biosynthesis.

As a result, the cell is not able to divide, and irreversible destructive processes occur in the structure of its cytoplasm and nucleotide. This is made possible by two special NO groups that activate free radicals under anaerobic conditions. However, this same property has negative consequences and for the macroorganism, which causes the high toxicity of the drug.

Pharmacological group

Synthetic antibiotics.

Release form of Dioxidin ®

The drug is produced by several Russian and foreign pharmaceutical enterprises from powdered raw materials yellowish color. The following dosage forms can be purchased in pharmacies:

An ointment intended for topical use, produced by Penza JSC Biosintez ®. The concentration of hydroxymethylquinoxyline dioxide is 5%.
Solution (used for infusion and topically) 5 mg/ml – product of Shchelkovsky OJSC “Valenta Pharmaceuticals” ®. Sold in pharmacy chains in five- or ten-milliliter glass ampoules, 3, 5 or 10 pieces in each package.
Dioxidine solution 10 mg/ml is 1 percent of the active ingredient in the drug. Produced by the companies "Valenta Pharmaceuticals" ®, OJSC "Novosibkhimpharm" ®, LLC "FERMENT" ® in ampoules of 5 or 10 ml, used for intracavitary administration and locally.

The solution contains, in addition to hydroxymethylquinoxaline dioxide, which makes up 0.5 or 1 percent of the total volume, water for injection. The latter is sterile distilled water, which serves as a universal solvent for many medicines.

Indications of Dioxidine ®

As mentioned above, Dioxidin ® is especially effective against anaerobic strains of pathogenic bacteria. Clinical studies, which lasted a decade and a half, revealed the high effectiveness of the drug in the antibiotic therapy of the following pathologies:

Cellulitis, pyothorax, peritonitis, pleurisy, abscesses of the lungs and mediastinum, in which the solution can be administered either intravenously or directly into the body cavity.
Trophic and wound infections, burns. In the latter case, the drug is especially effective in helping to avoid sepsis and speeds up healing.
Osteomyelitis.
Inflammation of system organs (for example).
Inflammatory processes in the mammary glands.

All of the listed diseases are treated in a hospital, but Dioxidin ® can be used on an outpatient basis, but only on the recommendation of the attending physician. Typically, the medicine in this case is used for antibiotic therapy of chronic or complicated bacterial infection, which long time does not respond to treatment with other antibiotics, and sinusitis. In this case it is done which reveals specific reason(type of pathogen).

Dioxidin ® in the nose for an adult: regimen and dosage

You can do rinsing yourself at home. For sinusitis or a runny nose, this method helps to quickly get rid of painful symptoms. It is recommended to use a solution for intracavitary administration (i.e. 0.5%) without dilution. The 1% drug is diluted with water in a one to one ratio.

Before rinsing, you should remove existing nasal congestion. If it is impossible to do this mechanically, you need to use special vasoconstrictor drops (for example, naphthyzine). It is also advisable to rinse the nasal passages saline solution, which thins accumulated mucus.

When the nose is completely clean, you can begin treatment. To do this, Dioxidin is drawn from the ampoule into a syringe, the needle is removed and the product is injected into the nasal passages one by one. The best option– tilt your head over the sink so that one nostril is located on top, inject the medicine into it. Then turn your face the other way so that the solution flows out of the second nostril.

Dioxidin ® can also be dripped into the nose of an adult. This method is more convenient and effective than washing. The solution prescribed is the same as in the previous case (0.5%), it does not need to be diluted. The treatment regimen is as follows: three times a day, after preliminary cleaning of the nasal passages, 2 drops of medicine are instilled into each of them. Since there are no special dosage forms for intranasal use, this is done with a pipette. Usually the duration of the course does not exceed 5 days, however neglected cases may require weekly therapy.

In addition to the finished medication in ampoules, the otolaryngologist can prescribe a combined composition based on it, which is prepared in a pharmacy according to individual recipe. The most common option is where dioxidin ® is combined with hydrocortisone. The main component fights the pathogen, and the auxiliary components provide the prevention of allergies and alleviation of symptoms due to the vasoconstrictor effect. Such mixtures can successfully treat bacterial rhinitis, but not all pharmacies manufacture such compositions.

Contraindications of Dioxidin ® and its side effects

Features of pharmacodynamics make the drug quite toxic and require some caution when using it (especially in patients with chronic failure kidney). The instructions for use strictly prohibit treatment with all forms of the drug for the following persons:

under the age of 18;
pregnant and lactating women;
having hypersensitivity to quinoxalines;
with a history of adrenal insufficiency.

The development of side effects is quite high, especially with intravenous and intracavitary administration. In these cases, there may be an increase in temperature accompanied by chills, headache, dyspepsia (nausea, vomiting, digestive disorders), photosensitivity and allergic reactions. If the drug is used topically, itching and periwound dermatitis are likely to occur.

How to dilute a solution for compresses and nasal drops for adults

For intranasal use in adults, 0.5% is usually used ready-made drug in ampoules without dilution. If a one percent solution is used, the medicine is diluted with water for injection (1:1). Compresses are prescribed, as a rule, in postoperative period for the purpose of preventing infection of sutures and therapy purulent wounds. This is usually done in a hospital setting by qualified health workers. However, it is also possible outpatient treatment compresses with dioxidine ®.

Trophic and purulent ulcers and wounds are treated by applying napkins soaked in a 0.5-1 percent solution, and deep injuries are loosely tamponed. For osteomyelitis of the extremities (with the formation of purulent areas), baths with a medicine of a similar concentration are indicated. The listed cases do not require breeding, but for postoperative sutures the drug must be diluted with isotonic saline solution or water for injection (to a content of active substance of 0.1-0.2 percent) in a sterile container.

How to store an open ampoule of Dioxidine ®

Ampoule dosage form long-term storage and does not imply reusable use.

Without compromising the integrity of the packaging, this medicine can be stored for 2 years, but it is better to throw away the opened ampoule with any remaining medicine. However, it is allowed reuse within 24 hours. To do this, you need to tightly close the hole with a piece of sterile cotton wool and place the ampoule in the refrigerator until the next use (before using it, warm it to room temperature in a water bath).

Instead of storing an open ampoule, Dioxidin ® is better to dilute and keep in the refrigerator for a day in a regular disposable syringe. This method is preferable, as it facilitates the use of the drug. Firstly, the measuring scale allows you to accurately measure the volume of the medicine itself and the dilution liquid. Secondly, it is much more comfortable to draw them from ampoules and vials. Thirdly, sterility is maintained both during dilution and during storage, and dripping from it is no more difficult than from a pipette.

Dioxidine ® solution in the nose of children: how to dilute?

As mentioned in the corresponding section, this medication is strictly contraindicated in patients under 18 years of age. However, in special cases its use is advisable. A pediatrician may prescribe medication to a child if a chronic form of rhinitis that is not amenable to antibiotic therapy with other medications is diagnosed. Beforehand, a bacterial culture must be done and the causative agent is determined, as well as an allergy test.

Because children are more sensitive to drug therapy and prone to allergic reactions(A children's dioxidin® is not available), the medicine must be diluted. To do this, the finished one percent preparation is usually diluted with saline solution in a sterile container in a ratio of 1:4. You need to drip three times a day, no more than two drops in each nasal passage. Course duration is from 3 to 5 days.

Sometimes the medicine is used in nebulizers. These devices have long proven their effectiveness, and in combination with a solution of hydroxymethylquinoxylin dioxide, such therapy allows you to quickly get rid of painful symptoms. The dilution should also be 1 to 4 (1% solution) or 1:2 if 0.5% dioxidin ® is used. Use only after consultation with a pediatrician and with his permission.

A warning to parents

The medicine is toxic, and the dilution scheme must be determined and explained by the doctor (the younger the patient, the weaker the concentration of the active substance should be). Unfortunately, many parents trust the advice of non-medical sites, forums and friends more, and non-specialists often confuse the names of drugs. For example, dioxidin ® and dimexide ®, and the difference between them is very significant.

Unlike the subject of this article, Dimexide ® is intended exclusively for external use for suppuration, burns and skin grafts, injuries and diseases of the musculoskeletal system (arthritis, bruises, sprains). In addition, children under 12 years of age should not use it. Without dilution, the product can cause chemical burn, which completely excludes the treatment of a runny nose in a child.

Dioxidin is an antibacterial drug. How chemical compound is a derivative of quinoxaline, which determines a wide spectrum of action against pathogenic and conditionally pathogenic microflora.

Most sensitive to medicinal product anaerobic microorganisms, blue-green pus stick, bacteria of the Enterobacteriaceae family, as well as enterococci.

In this article we will look at why doctors prescribe the drug Dioxidin, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS People who have already used Dioxidin can be read in the comments.

Composition and release form

A simple and memorable trade name hides a complex organic matter, called hydroxymethylquinoxaline dioxide. It is released in two different dosages, and when purchasing Dioxidin for nasal rinsing for sinusitis, this fact should be taken into account.

So, Russian pharmaceutical companies produce solutions of Dioxidin:

solution at a concentration of 0.5%. This form of release is used externally, intravenously and intracavitarily and is available in ampoules of 10 and 20 ml.
solution in a concentration of 1%, which is intended for intracavitary and external use and is packaged in glass ampoules containing 10 ml of the drug.

For rinsing the nasal cavity, the drug is most often used in a concentration of 0.1%.

What is Dioxidin used for?

The drug is used in surgery (neurosurgery), dentistry, urology, otorhinolaryngology for various types and forms of purulent infection. Diseases for which Dioxidin helps:

pustules on the skin;
lung abscess, pleural empyema, purulent pleurisy;
secondary purulent meningitis, brain abscess;
purulent mastitis, cystitis, peritonitis, sepsis;
inflamed wounds due to osteomyelitis;
phlegmon, skin abscess, trophic ulcers, burns, postoperative, post-traumatic wounds (superficial and deep);

ENT doctors prescribe instillation of the solution for rhinitis, sinusitis, and otitis.

Pharmacological action

Dioxidin is a broad-spectrum antibacterial drug.

When treating purulent wounds, damage to the integrity of the skin with severe exudation (wetting surface of the wound, most often found in burns), the Dioxidine solution accelerates wound cleansing, stimulates regeneration, and has a positive effect on the further course of the process.

Effective against infections caused by Proteus vulgaris (a type of microorganism that, under certain conditions, can cause infectious diseases of the small intestine and stomach), Pseudomonas aeruginosa, dysentery bacillus and Klebsiella bacillus (Friedlander - bacteria that cause inflammation of the lungs and local purulent processes), salmonella, staphylococci, streptococci, pathogenic anaerobes (bacteria capable of existing in the absence of oxygen and causing human diseases), including causative agents of gas gangrene.

Well absorbed from the surface of the skin and mucous membranes when local application. Does not bind to blood proteins and is excreted unchanged through the kidneys in the urine. Reaches maximum concentration 2 hours after administration. When administered intravenously, it does not have a broad therapeutic effect. Does not have the ability to accumulate (accumulate) in organs and tissues.

Instructions for use

Dioxidin solution according to the instructions for use is prescribed in a hospital setting. Apply externally, intracavity. Dioxidin 1% solution cannot be used for intravenous administration, due to the instability of the solution when stored at low temperatures.

Intracavitary administration:

The drug is usually administered into the cavity 1 time/day. According to indications, it is possible to administer a daily dose in two doses. If well tolerated and indicated, the drug can be administered daily for 3 weeks or more. If necessary, repeat courses are carried out after 1-1.5 months.
IN purulent cavity depending on its size, 10-50 ml of 1% dioxidine solution/day is administered. Dioxidine solution is injected into the cavity through a catheter, drainage tube or syringe.
The maximum daily dose for administration into the cavities is 70 ml of a 1% solution.

How to dilute for the nose:

Before you begin treatment, find out how to dilute dioxidin for nasal rinsing. Learn to maintain proper concentration and no complications will arise. For an adult, a medicine with a concentration of 0.5% is practically harmless. One percent dioxidine will have to be mixed with water in equal proportions. If you have to treat a child, dilute the 0.5% antibiotic with water in a 2:1 ratio. To prepare a solution of a medicine with a concentration of 1% for 1 part of the medicine, use 3-4 parts of water.

External use:

Apply 0.1-1% solutions of Dioxidin. To obtain 0.1-0.2% solutions, ampoule solutions of the drug are diluted to the required concentration with sterile isotonic sodium chloride solution or water for injection.
For the treatment of deep purulent wounds with osteomyelitis (wounds of the hand, foot), 0.5-1% solutions of the drug are used in the form of baths or special treatment wounds with a solution of the drug for 15-20 minutes (injection of the solution into the wound for this period), followed by application of bandages with a 1% solution of dioxidine.
To treat superficial infected purulent wounds, wipes moistened with a 0.5-1% solution of dioxidine are applied to the wound. Deep wounds after treatment, loosely tampon with tampons moistened with a 1% solution of dioxidine, and if there is a drainage tube, 20 to 100 ml of a 0.5% solution of the drug is injected into the cavity.
Dioxidin in the form of 0.1-0.5% solutions can be used to prevent infection after surgical interventions. According to indications (patients with osteomyelitis) and if well tolerated, treatment can be carried out daily for 1.5-2 months.

How to do inhalations:

To properly prepare a solution for inhalation, you need to monitor the proportion of the drug. If you are prescribed dioxidin for sinusitis or sore throat, use a solution of 0.25% concentration. To do this, mix one part of 0.5% medicine with two parts of water. Dioxidin with a concentration of 1% is diluted in double the volume of liquid. For one inhalation, no more than 4 ml of solution is used.

If we're talking about about the treatment of a child, in the process of preparing the solution for inhalation, use one and a half times more water(3:1 for 0.5% drug and 6:1 for 1% drug). The maximum volume of solution for one inhalation procedure is 3 ml. Calculate the concentration with extreme care, otherwise you may damage the mucous membranes.

Contraindications

The drug has contraindications:

Hypersensitivity to the components of the drug;
Kidney failure;
Adrenal insufficiency.

It is strictly prohibited for pregnant women and nursing mothers, because it damages the fetus and causes gene mutations.

Side effects

When dioxidine is administered into a vein or cavity, headaches, chills, increased body temperature, dyspepsia (digestive disorders), and convulsive twitching of the mouse are possible.

For warning adverse reactions It is recommended to prescribe antihistamines and calcium supplements. If adverse reactions occur, reduce the dose and prescribe antihistamines, and if necessary, stop taking dioxidine.

Analogs

Drugs that are similar in their action or contain the same active ingredient:

Dioxysept;
Diquinoxide;
5-NOK;
Galenophyllipt;
Monural;
Utrotravenol;
Hexamethylenetetramine and others.

Attention: the use of analogues must be agreed with the attending physician.

Prices

The average price of DIOXIDINE, solution in pharmacies (Moscow) is 185 rubles.

Storage conditions and periods

List B. Store out of the reach of children, protected from light at a temperature of 18° to 25°C. Shelf life – 2 years.

Conditions for dispensing from pharmacies

The drug is available with a prescription.

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A runny nose is common occurrence, especially in the autumn-spring period. It can appear in both children and adults. Hypothermia, weakened immunity, viral infection - all this and much more can cause the development of an inflammatory process in the nasal cavity. Nasal congestion can be disconcerting both day and night. Despite this prevalence of rhinitis and its apparent innocence, it is worth noting that untimely treatment of a runny nose can lead to the development of complications from respiratory system, which will be much more difficult to cure. Often, for the treatment of rhinitis, doctors prescribe vasoconstrictor drops, in addition to traditional and known means, some experts prescribe Dioxidin drips into the nose.

The solution is widely used in medical practice, for example, in the treatment of purulent wounds, as well as in surgery as antiseptic. The use of Dioxidin in the nose became possible due to its pronounced antimicrobial properties, as well as the absence of toxic effects.

Medicinal properties

Dioxidin nasal drops have pronounced antibacterial and antiseptic properties. Hydroxymethylquinoxaline dioxide is the main active ingredient a medicine that destroys the protective shell of the pathogenic organism, leading to its death. The drug is available in ampoules and also as an ointment.

It should be noted

An ENT specialist should explain how to dilute an antibiotic for instillation into the nasal cavity, taking into account the characteristics of the patient’s body and the severity of his pathology.

Instructions for use in nasal ampoules for adults

IN inpatient conditions Dioxidin 1% is combined with water to prepare injections. For rinsing, an adult is prescribed no more than 70 ml of medication diluted with saline in a 1:1 ratio. When a 0.5% concentration is prescribed, there is no need to dilute it.

The instructions for the antimicrobial synthetic chemical intended to eliminate rhinitis in adults recommend acting according to the following methods:

Washing. To carry out the procedure, special catheters, a syringe or a pipette are taken. The liquid is administered 1-2 times a day. The prescribed dose is poured into the nostril, while the patient must lie down. After 20 seconds, you should blow your nose well and only then repeat rinsing the second nasal canal. Before manipulation, the nasal passages are cleared of crusts and mucus.

Burial. The patient tilts his head back and injects 3 drops of the chemical into each nostril. The procedure is repeated three times a day.

Inhalations. Prescribed in cases where bacterial rhinitis is complicated by the development purulent lesion upper respiratory tract. Also sinusitis. For medical practice Nebulizer is suitable. An ENT specialist will tell you how to dilute an antibacterial agent for inhalation.

Typically, a 1% composition is diluted with saline in the proportion one to four, and 0.5% - in a ratio of one to two. Nebulizer physiatry is performed twice daily. Do not spray more than 8 ml of medicine at a time.

How many days to take intranasal drops or do inhalations should be prescribed by your doctor. As a rule, for complete cure For rhinitis, 3-7 days are enough.

For severe illnesses, the course of physiotherapy can last up to 4 weeks. If there is a need, therapeutic manipulations Repeat again after a month of rest.

Dioxidine in a child's nose

Since the quinoxaline derivative is a powerful antibiotic with toxic effects, it is extremely rarely recommended in the treatment of ENT diseases in children.

Attention

But in case of low effectiveness or absence of any results from the use of other antibacterial agents, the doctor may decide to prescribe a medicinal composition, strictly selecting the dosage for each child individually.
At what age can it be recommended for children?

A 1% antiseptic must be diluted with saline solution. Typically, children are prescribed a 0.5% concentration, since high doses of hydroxymethylquinoxaline dioxide can lead to gene mutation in a child.

This solution is advisable in cases where the treatment of chronic purulent infections does not give the required results. At home, it is undesirable to fight ENT disease with a toxic antibiotic.

The drug is sold in 10 ml ampoules and in ointment form. Available in pediatrics antimicrobial drops. Moreover, the instructions indicate that you should not wipe your nostrils with tampons soaked in the prepared solution, as this can lead to damage to the baby’s delicate mucous tissue.

Besides

It is prohibited to practice in rinsing the paranasal sinuses, since the liquid can enter the Eustachian tube, which can be fraught with otitis or pharynx and thereby cause an overdose.

The procedure for instilling a nose in children is carried out as follows:

The child’s nostrils are cleaned of infectious exudate and dried crusts.
The ampoule of 0.5% or 1% (diluted with saline) is opened and pipetted.
Drop 1-2 drops into both nostrils (strictly adhering to the doctor’s prescriptions).
Then the child must tilt his head back so that the active substance penetrates deep into the nasopharynx and sinuses.

Instillation is repeated up to three times a day. The maximum treatment course should not exceed 7 days. After opening, the ampoule is stored in the refrigerator for 24 hours.

Complex nasal drops: composition dioxidine hydrocortisone mezaton

Often, for rhinitis or sinusitis of mixed infectious etiology, otolaryngologists prescribe a prescription for medications consisting of several active ingredients.

This is especially true for diseases that provoke the development of serious complications in lower parts respiratory system. For example, Dioxidine can be mixed with Hydrocortisone, Prednisolone, Dexamethasone (hormonal anti-inflammatory drugs).

Mezaton, Farmazolin, Ephidrine are used as vasoconstrictor components. Often the composition includes sodium sulfacyl.

Here are some effective recipes:

Dioxidin 1% and Galazolin 0.1% take 5 ml each and add Dexamethasone 0.1% in a volume of 2 ml.
An ampoule of Dioxidin 1% is diluted with 2 ml of anti-inflammatory Hydrocortisone 2.5% and 1 ml of vasoconstrictor Metazon 1%.
Instead of Mezaton, you can take Farmazolin 0.05% in a volume of 5 ml. Dioxidin concentration is reduced to 5% and only 5 ml is taken medicinal substance. And Hydrocortisone is left in the same amount as in previous recipe– 2 ml.

If an otorhinolaryngologist prescribes Mezaton, Dioxidin and Dexamethasone in the nose, the mixing proportion is selected depending on the age of the patient, individual characteristics person, the severity of the disease and the duration of its course.

Important to note

Many of the prepared liquids can act not only locally, but also systemically. If these points are not taken into account, the medicine can have serious side effects.

The main advantages of complex drops with several types active substances is adaptation to a specific person.

The ENT specialist can be confident that therapeutic manipulations will not cause allergies and will effectively fight infectious agents.

You can also add plant extracts to the recipe, which alleviate health conditions and soften the aggressive effects of the selected ingredients.

Quinoxaline derivatives should not be used by people intolerant to the drug. Since it is excreted by the kidneys, it is contraindicated in adrenal insufficiency. As already mentioned, It is prohibited to use during pregnancy and children under 7 years of age.

Nasal rinsing with Dioxidin or sinusitis for patients with renal failure is not a contraindication, but is carried out under the supervision of a physician with extreme caution.

Even the dosage of ointment for external application should be strictly selected by the attending physician. It is placed using a turunda or a cotton swab, which is removed after 15 minutes. If necessary, reduce the dose.

Side effects

When Dioxidin is administered, sick people may experience negative reactions of the body, manifested by the following symptoms:

Fever;
Muscle spasms, chills;
Headaches;
Allergy;
From the gastrointestinal tract, nausea or vomiting is possible.

If an antimicrobial drug is applied to the skin for wounds of bacterial origin, patients may develop dermatitis around the injury.

IN in rare cases due to the increased dosage, patients experience the appearance of skin age spots. The fact is that a group of quinoxaline derivatives can increase individual skin sensitivity to ultraviolet rays.

Pigmentation usually occurs on the hands or face. But such a side effect disappears after a simultaneous increase in the time between the use of an antimicrobial drug or a reduction in its dose.

If preventive measures do not provide positive result, the antibacterial medicine is discontinued.

To avoid the development of side effects during treatment, tolerance tests are carried out. To do this, a 1% concentration of drops is instilled intranasally and after 3-6 hours the patient’s health condition is assessed.

If no negative manifestations does not occur, then continue therapeutic manipulations.

Since the quinoxaline derivative inhibits the function of the adrenal cortex, it is very important to use it carefully in people with chronic renal failure.

Doctors prescribe a lower dose, reduce the frequency of intranasal procedures (rinsing, instillation, inhalation) and shorten the duration of treatment.

If the patient has developed acute sinusitis, then the simultaneous use of antihistamines with an antibacterial component is not recommended.

Antiallergic drugs reduce mucus production, which inhibits the drainage function of the paranasal sinuses. Therefore, with sinusitis acute course the antiseptic is temporarily discontinued.

If the inflammation of the maxillary cavities is chronic, then antihistamine tablets or injections are suitable for simultaneous use in treatment. But to improve mucus drainage, patients are advised to frequently rinse their nose with saline liquids. This action helps to avoid drying out of the mucous membranes.

In case of overdose, the following symptoms may occur:

Acute adrenal insufficiency;
Arrhythmias, decreased blood pressure;
Nausea, diarrhea, flatulence, vomiting;
Lethargy, hallucinations;
Epileptic or muscle cramps;
Coma.

Symptoms of overdose are relieved by completely stopping the drug and prescribing hormone replacement therapy.

Analogs

When there is an individual intolerance to Dioxidin, solutions with similar action for pathogenic microorganisms. Analogues of a broad spectrum antibacterial agent are:

Dioxysept
Urotravenol
Diquinoxide

These drugs also destroy pathogens: cocci, Pseudomonas aeruginosa, pathogenic anaerobes, etc. They are prescribed if other types powerful antibiotics cannot eliminate the pathological process or are contraindicated.

In general, Dioxidin is a drug intended for adults. It has a strong medicinal effect and contains toxic substances. But sometimes the drug is prescribed to children when, in the opinion of the doctor, the intended benefit to the child is higher than the potential danger. Due to the high risk of developing adverse reactions the medicine is usually used in hospital settings. Home treatment is permissible only as prescribed and under the strict supervision of a doctor.

Dioxidin is a broad-spectrum antibiotic.

Composition and effect of the drug

Dioxidin is a broad-spectrum antibacterial drug. It is effective against most aerobic (which require air to live) and anaerobic (living in environments without oxygen) microorganisms, while conventional antibiotics only act against a few types of bacteria from one of the above groups.

The active component is hydroxymethylquinoxaline dioxide. This is a toxic substance with strong bactericidal properties: after contact with it, hostile microflora quickly dies.

Indications

The active component of Dioxidin has medicinal properties when used in small quantities, and if they are slightly exceeded, a toxic effect may already occur. When used to treat a child, it is important not to cross the line between medicinal dose and one that will lead to poisoning.

Only a doctor can prescribe the drug.

The product is used only according to strict indications. It is usually prescribed when antibiotics with soft action did not give the desired effect, or the patient needs urgent and strong antibacterial therapy. This happens with purulent-inflammatory diseases of the abdominal organs or soft tissues.

Despite the fact that, according to the instructions, Dioxidin is contraindicated for children, the medicine has also found use in pediatrics.

bronchitis;
pleurisy (inflammation of the pleura);
pneumonia (pneumonia).

The medicine will help with pneumonia and bronchitis.

Usually, before prescribing Dioxidin, they try to eliminate inflammation gently active antibiotics. But if gentle therapy does not help, and the disease progresses, a remedy with a strong effect is required for the child’s recovery.

Manufacturers, prices, release forms

Dioxidin is produced by Russian companies:

JSC "Biosintez" (Penza);
LLC "Mir-Pharm" (Moscow);
OJSC OJSC Novosibkhimpharm (Novosibirsk);
JSC "Moskhimfarmpreparaty" named after. N.A. Semashko" (Moscow).

The drug is available in the following dosage forms:

ointment 5%;
solution 0.5%;
solution 1%.

For the treatment of children, a 0.5 percent solution is used Dioxidine in 5 ml ampoules. They are sold in 10 or 20 pieces on pallets placed in a box, which additionally includes an ampoule knife and instructions for use (). The price in Russian pharmacies is from 387 rubles.

Dosage and administration

Dioxidin is prescribed to a child for instillation into ears and nose(for otitis media or runny nose) or carrying out inhalations(for purulent-inflammatory diseases of the lower respiratory tract - for bronchitis, pneumonia, less often - for sinusitis).

Important! Before starting treatment, check how he responds children's body on a heavy drug. To do this, drop 1-2 drops of Dioxidin into the nose or ear. If no adverse reactions appear within 6 hours, the product can be used further.

Treatment of otitis media

To put the medicine in your ear, you will also need:

pipette;
cotton swabs;

Use cotton swabs with a stopper for added safety.

hydrogen peroxide 3%.

Important! Remove the ampoule from the refrigerator in advance and place it in a warm place.

Cold drops will cause pain after use, and they should not be heated. The temperature should rise naturally. Otherwise, the product will lose its healing properties.

Directions for use:

Soak a cotton swab in a solution of hydrogen peroxide and clean the ear canals from pus.
Carefully open the ampoule and draw up its contents using a pipette.
Ask your child to lie on his side.
Pull the pinna back to straighten the ear canal.
Place in sore ear Add 2-3 drops of medicine and wait about 5 minutes.
Turn the baby over to the other side and repeat steps. 4-5.

Place an antibiotic in the ear when severe course acute otitis media.

Dioxidin with should be instilled 3 times a day with an interval of 8 hours. The duration of the course of treatment is determined by the doctor. Usually it is 3-5, but no more than 7 days.

Treatment of a runny nose

Before instillation, clean the nasal passages with saline solution (0.9% sodium chloride solution). To do this, take the rinsing liquid into a pipette and drop it in accordance with the dosage according to age into each nostril:

infants - 1 drop;
from 2 years - 2 drops.

For this you can also use products based on sea water (Aquamaris, Quix, Dolphin, Aqualor).

Before instillation, thoroughly clean your nasal passages with salt water.

Attention! sea water often sold in pharmacies in spray form. It sprays when pressed high pressure which promotes blockage auditory tube mucus. As a result, otitis media may develop. To prevent this from happening, use drops for children under 2 years of age.

Use an aspirator to clean the small nose.

Wait 10-15 minutes after rinsing and let the child blow his nose or use it. Then:

Place your baby on a flat surface (without a pillow) on his back.
Open the ampoule and draw the medicine into a pipette.
Place 2 drops in each nostril and let your baby lie there for a few minutes.

Children should drip Dioxidin into the nose every 8 hours (3 times a day) for 3 to 7 days.

Inhalations

If the doctor has prescribed inhalation, use a special device that turns the medicine into a therapeutic aerosol that can be inhaled using a mask.

Inhalations can be done at home, but only with the permission of a doctor.

Step by step instructions:

Open the ampoule with Dioxidin 0.5% and draw it into the syringe.
Mix the product with two parts of saline solution (for 5 ml of medicine you will need 10 ml of sodium chloride solution).
Use a syringe to draw 3 ml of the resulting liquid and release it into a sterile inhaler cup.
Put a child's mask on your child and perform inhalation. Its duration for children from 2 to 6 years old is 1 minute, from 6 years old - 2 minutes.

Attention! To prepare an inhalation solution, you can use Dioxidin 1%. But then you need to dilute it with 4 parts of saline (for 5 ml of medicine you will need 20 ml). 3 ml of the resulting liquid is added to the nebulizer.

For better absorption of the medicine, inhalation should be carried out 1.5 hours after meals. You can do 1-2 procedures per day with an interval of at least 12 hours. Duration of treatment is 3-7 days.

Side effects

When treated with Dioxidin, side effects may develop:

chills;
weakness;

Taking the drug may be accompanied by drowsiness and lethargy.

fainting;
headache;
dizziness;
nausea and vomiting;
increase in temperature;
allergic reactions;
increased salivation;
disruption of the digestive system.

Important! If you encounter side effects in a child, talk to your doctor about the advisability of treatment with the drug and the possibility of replacing it with another.

If the child’s body has a strong reaction (several effects at once), call an ambulance.

Dioxidin for children: pros and cons

If the drug contains toxic substances and the medicine is contraindicated for persons under 18 years of age, should it be used by children? Let's listen to feedback from parents and medical practitioners.

Sofia Anatolyevna Cherkasova (therapist) refers to the use of Dioxidin in pediatrics as follows:

“This is a potent antibacterial drug that gives rapid healing effect. But it is difficult to dose because the poisonous dose is only slightly higher than the medicinal dose. This is why there are so many adverse reactions. That is why Dioxidin is indicated only for adults. However, according to some data, its use is allowed in otolaryngology from the age of 12. In practice, some pediatricians recommend the solution for instillation into the nose and ears from 2 years of age.

It is dangerous to treat infants with this medicine, because There is no information about how the drug affects children at this age. And even despite this, doctors sometimes prescribe it for babies up to one year old. Moreover, they select the dosage “by eye,” starting with the lowest dose.

Parents should make the decision to treat their child with Dioxidin and take responsibility for this at their own peril and risk. I believe that the drug can be used for children from school age and serious illnesses. But before that, it’s better to try other, safer means.”

At bacterial rhinitis and otitis in children are used:

Instead of Dioxidin, the doctor may prescribe Polydex, a local antibiotic.