Valerian extract - medicinal product with a sedative (calming) effect. It is used to treat mild disorders associated with increased irritability and excitability. The product also has a light antispasmodic effect.

The drug is available in tablets, the active ingredient is a thick extract of valerian officinalis. Also includes excipients: starch, gelatin, primellose, calcium stearate. They are added to obtain the required mass and shape, provide hardness and stability during storage, as well as good solubility after oral administration.

Valerian extract tablets are coated with a yellow, sometimes brown; can be placed in a blister pack or poured into a transparent glass bottle (50 tablets). Because of the glazed coating, they are often called dragees. One tablet contains 20 mg active substance.

In Russia, valerian tablets are produced by several enterprises: Dalkhimfarm, Ozon, Biosintez, Pharmstandard, PharmVilar.

Mechanism of action and indications for use

The extract is obtained from the roots and rhizomes of valerian officinalis; its active components are isovaleric acid ester and borneol alcohol. They have a sedative and antispasmodic effect, calm the nervous system, and have a relaxing effect on the walls of blood vessels and muscle tissue.

The therapeutic effect develops slowly, but with constant use (course) a stable positive reaction body to the drug.

Indications for taking valerian extract:

Tablets are over-the-counter drugs and can be purchased independently at a pharmacy without a doctor’s prescription. However, for long-term use need to consult a doctor.

Contraindications for use

Also, the instructions for valerian tablets prohibit their use in children under three years of age. If it is necessary to treat a child, use valerian tincture in the amount of “one drop per year of life” or use other sedatives permitted for children.

Other contraindications: lactase and sucrase deficiency, glucose-galactose malabsorption, fructose intolerance, increased sensitivity to valerian.

Rules for taking the drug

Instructions for use of tablets Valerian includes recommendations on the regimen for taking the medication: the drug is taken orally, 1-2 tablets after meals, three times a day. Increasing the dosage can only occur with the permission and under the supervision of a physician. The course of treatment lasts from two to four weeks.

The instructions for valerian extract contain a clarification that the drug enhances the effect of sleeping pills, so valerian tablets cannot be used simultaneously with other drugs that affect the central nervous system without consulting a doctor.

Side effects

If the dosage is exceeded, the extract can cause:

• lethargy;
• apathy;
• drowsiness;
• decreased attention and performance;
• muscle weakness;
• allergic reactions;
• constipation

In case of severe overdose, arrhythmia and slow heartbeat develop.

Particularly dangerous uncontrolled reception valerian for people whose work requires increased attention. This category includes drivers and operators of various mechanisms.

If side effects develop, you need to immediately stop taking the drug, rinse the stomach or induce vomiting, take enterosorbent ( activated carbon, Enterosgel) to slow down the absorption of valerian into systemic blood flow and remove the substance from the body.

Some medications already have a fairly long history of helping people. Valerian belongs to such household long-livers. Reviews of this product have been left by more than one generation of those who have taken drops and tablets with this name.

Where does valerian grow?

People learned about the plant valerian officinalis many, many centuries ago. After all, its homeland is the Mediterranean. It was there that it began to be used as a sedative. The plant itself and its medicinal use spread throughout Europe. For more than 200 years it has been introduced into cultivation as a honey plant and medicinal plant. Now Valerian officinalis grows in wildlife, in lowland areas, on the edges of forests in temperate and subtropical zones, and is also grown in cultivation for the needs of the pharmaceutical industry.

Medicinal properties of the plant

Valerian medicinal raw materials serves as a rhizome with roots, they are dug up at the end of summer - beginning of autumn, washed and dried in natural conditions, and the thickness of the layer of raw materials is reduced every 2-3 days, bringing it to one row. Such a long process allows you to obtain a more fragrant and useful substances raw materials. Science has identified the following substances in the roots and rhizomes of valerian:

• alkaloids (traces);
• valerian-borneol ester;
• glycosides;
• tannins;
• isovaleric acid;
• butyric acid;
• formic acid;
• palmitic acid;
• saponins;
• resinous substances;
• terpenes;
• acetic acid;
• malic acid.

Pharmaceutical studies have proven that valerian officinalis has the ability to enhance inhibitory processes, reduce reflex excitability, and relax smooth muscle spasms. Plant extracts can be successfully used as a sedative for insomnia, neuroses, spasms of the coronary vessels, migraines, and constipation. All beneficial properties Valerian officinalis is used in the pharmaceutical industry to create medications.

Pharmaceutical group of drugs

A wide group of herbal and synthetic-based drugs are used to reduce emotional stress. It gets its name from the Latin word sedatio (sedation) - sedatives. One of the medicines belonging to this group of drugs is valerian tablets. Instructions for use, reviews of patients and doctors about it will be discussed in this article.

How is the drug produced?

Valerian extract in tablets, reviews of which have been left by many generations of patients, has a long history of its origin. It contains one active component - rhizome with valerian roots, ground into a fine fraction. Additive in the form of carbonatemagnesiumhelps work intestinal tract. The tablets also contain substances that play the role of formative components.

There is no official data yet on how exactly valerian preparations work in the human body. It is unknown how the sedative mechanism is triggered active ingredients this plant. But for patients this is not so important, the most important thing is that science has proven its effectiveness, which is confirmed by many years of use in folk and clinical medicine. Now valerian tablets receive overwhelmingly positive and recommendatory reviews from patients and doctors.

Why is the medicine “Valerian” prescribed?

One of the most frequently purchased medicines in the pharmacy chain by buyers of different age groups- “Valerian.” This medicine has received the most grateful reviews for many decades. This remedy is based on the roots and rhizomes of the plant of the same name. The drug is completely natural. For what diseases and conditions is it prescribed for use? The drug is used as independent remedy or in complex therapy for problems such as:

• insomnia;
• vegetative-vascular dystonia;
• migraine;
• neuroses of cardiac etiology;
• nervous excitement;
• hepatic colic;
• renal colic;
• rushes of blood to the head during menopause.

Only in combination with others medicines and physiotherapy this drug is used for:

• functional disorders of the heart vascular system;
• spasms of the gastrointestinal tract.

When should the drug not be taken?

The drug in Valerian tablets has mostly positive reviews, although there are also those that carry neutral and, very rarely, negative information. After all, like all medicines, this herbal preparation has its contraindications for use. This medicine is on plant based should not be taken for the following health conditions:

• high sensitivity to the components of the drug;
• glucose-galactose malabsorption.

Also, this medicine should not be taken by children under three years of age and by women in the first trimester of pregnancy. This is due to the lack of specific clinical data on which of the active components of the root with valerian rhizomes provide a therapeutic effect.

How to take the pills?

It will tell you about the cases in which it is used and how to use valerian extract in tablets, instructions. Reviews about the drug will help you understand whether there is a need for use this tool unless recommended by the attending physician. After all, very often this drug is bought just like that, just in case, on the advice of relatives or friends. Therefore, it is used without consulting a doctor. Medicines based on the root of valerian rhizomes are produced by many pharmaceutical companies. But the dosage of the active component in them remains the same - one tablet contains 200 mg of valerian extract.

Tablets are packaged either in blisters and cardboard packs, or in jars, glass or plastic. Usually for treatment various conditions 1-2 tablets of the medicine are prescribed for use three times a day. The drug is taken after meals. Daily norm can be increased only after consultation with your doctor medical indications. Valerian extract is taken in a course that can last from 2 to 4 weeks.

What may appear more if you take long time Valerian tablets, benefits and harm? Reviews from patients indicate that long-term regular use of tablets with valerian affects well-being: drowsiness and muscle weakness, Although correct treatment this drug in the prescribed course has such an effect in a very in rare cases.

Despite the fact that valerian extract is a drug plant origin and is considered harmless by the vast majority of consumers, you should consult your doctor about its use. It is possible that the condition identified as a result of the examination will require complex therapy, further thorough examination for diagnosis.

Valerian and other medicines

The drug “Valerian” has been receiving reviews for more than a decade, mostly only grateful ones. Most patients are satisfied with the effect of the drug, which copes well with the stated indications for use. Taking valerian helps you calm down, fall asleep, relieve stomach cramps and calm headache. Very often this substance is used in combination with other components. For example, tablets "Valerian with motherwort".

Valerian is available in almost every home, because we use it quite often: someone, thanks to valerian tablets, provides themselves with strong good sleep, while others relieve anxiety and stress. At the same time, few people think that this is also a medicine, so its uncontrolled use is unacceptable. We suggest that you familiarize yourself with the contraindications, side effects and instructions for use of this medication.

Valerian - Mediterranean medicinal plant, the sedative properties of which were discovered many centuries ago. Over time, its use spread throughout Europe and today enjoys high popularity among other sedatives, despite the many existing analogues, such as Valocordin, Central-B, Nervanorm, etc. and other commercial names of valerian, for example, Valdispert, Valeriana forte and Dormiplant-valerian.

Instructions for use of valerian

Valerian is the most popular and relatively safe drug with a moderate sedative effect. By pharmacological actions This effect is explained by the presence in its composition essential oil based on isovaleric acid and borneol; it appears 30 minutes after using the medicine and remains relatively for a long time.

Release form and composition of valerian

The resulting effect occurs due to the expansion of the coronary vessels, which are expanded by the components included in the drug. They also actively influence the growth of secretion of the gastrointestinal tract and have a moderate choleretic effect. However, if you are treated with valerian for a long time, the tablets can provoke hypotension, so you need to know the features of this drug and take it according to the instructions, after consulting with your doctor first.

Valerian is available in the form liquid tincture and tablets. The main component of the drug is thick valerian extract. The medicine also contains starch, gelatin, magnesium carbonate; sugar, croscarmellose sodium, essential oils, chatinin and calcium stearate.

Indications for use

The drug is prescribed in the following cases:

And also valerian tablets prescribed to relieve spasms of the gastrointestinal tract and cardiovascular system body.

Contraindications

It is contraindicated to take valerian in the following cases:

It is also contraindicated to take valerian while driving. vehicles and when working with mechanisms that are potentially dangerous and require concentration. Particularly dangerous take this medicine with alcohol. And also during the period of treatment with the drug it is recommended to refrain from overuse strong tea, coffee and energy drinks, as they can block the expected effect of this medication.

Dosage and method of administration

Officially established daily dose valerian - no more than 200 mg.

Considering that one tablet of valerian extract contains 20 mg of active ingredient, the dose of tablets per day is 10 g. In this case, the dosage of one dose, as well as the number of doses of the drug per day installed individually.

The duration of taking this drug is also determined individually for each patient. Experts say that the period of use of valerian tablets is 10 - 30 days. If it is necessary to extend the course of treatment, you must follow the doctor’s instructions, since only a specialist will be able to determine the feasibility prolongation of taking this drug.

Taking valerian during lactation and pregnancy

The dose of the drug during pregnancy and lactation depends on the period of gestation of the baby. After the first trimester, taking pills is prohibited, and for pregnant women who are more pregnant later(for example, in the second and third trimesters) the drug is permitted under the strict supervision of doctors.

Valerian during pregnancy designated as relatively safe sedative, because for expectant mother sudden changes are undesirable for the baby hormonal levels, provoking a state of increased emotional instability.

When breastfeeding, valerian can also be taken only after this drug has been approved by a doctor and prescribed suitable dosage, which should be strictly adhered to, because the medicine easily gets into breast milk, which can cause sleep disturbances and an allergic reaction in the baby.

Overdose and consequences

In case of an overdose of valerian, weakness, drowsiness, and decreased active work, lethargy and other side symptoms, as well as symptoms of depression in the central nervous system.

In case of severe overdose, arrhythmia and bradycardia may occur. As a rule, such symptoms begin to appear when taking significantly large doses drug (exceeding usual dose 20 times or more). However, exact data on how many tablets can cause such phenomena have not been established, since it depends on the characteristics of the body.

Lethal dosage Pharmacists have not identified the drug, but the risk fatal outcome is not excluded, since much depends on the amount of overdose and the person’s state of health.

If symptoms associated with an overdose begin to bother the patient and his condition worsens, it is necessary to immediately discontinue the drug, drink activated carbon and magnesium sulfate, which will prevent intestinal absorption of the substances and cause a laxative effect.

There is no specific antidote for valerian.

Side effects

Despite the fact that valerian is used according to the recommended regimen and doctor’s prescription, the possibility of manifestation side symptoms quite high, so you should pay attention to conditions such as :

If any of the above side effects bothers the patient, it is necessary to urgently stop taking the pills and consult a doctor. Do not forget that there is a risk of allergic reaction Almost every person after consuming valerian, even if previously similar phenomenon not noted.

Interaction with other drugs

Valerian tablets, due to their properties, can enhance the effect of sleeping pills, sedatives, as well as the effect of antispasmodics. Therefore, before using this drug, you must tell your doctor about all medications that the patient used before treatment or if you used valerian along with other medications.

ABON BIOPHARM (Hangzhou) Co., LTD Biosynthesis OJSC Borisov Plant medical supplies, OJSC Borisov Plant of Medical Preparations, RUE Veropharm, JSC Vilar PEZ State Unitary Enterprise Dalkhimfarm OJSC Kvadrat-S, LLC Moskhimfarmpreparaty FSUE im. Semashko OZONE, LLC POLIPHARM ICN Tatkhimfarmpreparaty OJSC THFZ ICN PharmVilar NPO LLC Pharmstandard, LLC Pharmstandard-Tomskkhimpharm, OJSC SHCHELKOVSKY VITAMIN PLANT Evalar CJSC

Country of origin

Republic of Belarus Russia

Product group

Herbal, natural preparations (herbs)

Herbal sedative

Release forms

• 10 - contour cell packaging. 50 - dark glass jars. 50 - bottles. 10 - contour cell packaging. 50 - bottles. 10 pcs. - contour cell packaging (1) - group packaging 10 pcs. - contour cell packaging (5) - cardboard packs. 50 tabs per pack, cover. coated, 20 mg: 50 pcs. tablets 0.25 g - 300 pcs per pack. pack of 10 tablets pack of 50 tablets bottle of 50 tablets

Description of the dosage form

• tablets 104 mg tablets, coated film-coated yellow. Food and energy value per 100 g: carbohydrates 50 g, fats 1 g, calorie content 210 kcal (877 kJ) film-coated tablets Film-coated tablets Yellow film-coated tablets, biconvex Yellow film-coated tablets, biconvex.

Pharmacological action

Valerian extract standardized for the content of valerenic acids (France) In the production of Valerian tablets, Evalar extract uses raw materials from leading manufacturers in France and Germany. How do the ingredients work? Valerian rhizomes with roots - Valeriana officinalis, subfamily Valerianoideae of the Honeysuckle family (Caprifoliaceae). Perennial herbaceous plant. Rhizomes with valerian roots contain essential oil, which includes bornyl isovalerianate, isovaleric acid, borneol, pinene, terpineol, sesquiterpenoids (valerianal, valerenone, valerenic acid), free valeric acid, valepotriates, triterpene glycosides, tannins, organic acids, alkaloids, valerine, hatinin, pyrryl methyl ketone, free amines. Valerian preparations, both separately and in the form multicomponent products used for increased nervous excitability, psychasthenia and neurasthenia, accompanied by insomnia, a feeling of tension and increased reactivity, as well as menopausal disorders, vegetative-vascular dystonia and neuroses. Valerian has an effect during systematic and long-term use. Glycine is the simplest aliphatic amino acid. Glycine is necessary for the synthesis of nucleic acids, bile acids And nonessential amino acids in the body. Participates in the synthesis of creatine, a substance contained in muscle tissue. Important for function prostate gland, required for central nervous system, participates in the transmission of nerve impulses, serves as an inhibitory neurotransmitter. It has some nootropic properties, improves memory and associative processes. Taking 6 tablets per day provides at least 0.6 mg of sequiterpene acids in terms of valerenic acid, which is 30% of the adequate intake level.

Pharmacokinetics

Valerian extract tablets have been poorly studied, which is due to the impossibility of accurately identifying the active principle of the drug. After ingestion of 600 mg of dry valerian extract, the maximum concentration of valerenic acid (one of the probable active components) is reached after 1-2 hours and is 0.9-2.3 ng/ml. The half-life of elimination is 1.1 ± 0.6 hours. With repeated use of the drug, its pharmacokinetics does not change.

Special conditions

During the treatment period, care must be taken when driving vehicles and engaging in other potentially dangerous species activities requiring increased concentration attention and speed of psychomotor reactions. Use during pregnancy and lactation The use of the drug during pregnancy (first trimester) is contraindicated. Considering side effects the drug must be used with caution during lactation.

Compound

• 1 tab. thick extract of rhizomes with valerian roots 20 mg thick valerian extract (containing the sum of carboxylic acid esters in terms of valerenic acid ethyl ester - 1.8%) - 20 mg. Excipients of the core: sucrose (refined sugar) - 5 mg, calcium octadecanoates I-water (calcium stearate monohydrate) - 1 mg, magnesium hydroxycarbonate (basic magnesium carbonate) - 20 mg, lactose monohydrate (milk sugar) - 43.11 mg , polysorbate (Tween 80) - 0.2 mg, potato starch - 10.69 mg. Excipients of the shell: sucrose (refined sugar) - 68.433 mg, titanium dioxide (titanium dioxide) - 3.02 mg, povidone (low molecular weight medical polyvinylpyrrolidone) - 0.56 mg, magnesium hydroxycarbonate (basic magnesium carbonate) - 17.1 mg , polysorbate (Tween 80) - 0.74 mg, colloidal silicon dioxide (Aerosil) - 0.008 mg, quinoline yellow dye (quinoline yellow sykovit 70 E 104) - 0.035 mg, magnesium hydrosilicate (talc) - 0.005 mg, sunflower oil - 0 .06 mg, beeswax - 0.025 mg, solid paraffin (paraffin) 1 tab. thick valerian extract 20 mg Excipients: magnesium hydroxycarbonate (main magnesium carbonate), potato starch, talc, gelatin, sucrose (sugar), low molecular weight medical povidone (polyvinidepyrrolidone), colloidal silicon dioxide (aerosil), titanium dioxide, beeswax, tropeolin O . valerian extract thick 20 mg; Excipients: sucrose, calcium stearate, magnesium hydroxycarbonate, lactose, polysorbate, thick potato starch extract of valerian - 20 mg, excipients: basic magnesium carbonate, potato starch, talc, gelatin, sugar, titanium dioxide pigment, beeswax, paraffin , sunflower oil, quinoline yellow E 104, colloidal silicon dioxide. thick valerian extract 20 m. excipients: (basic magnesium carbonate; potato starch; talc; food gelatin; refined sugar; titanium dioxide; beeswax; paraffin; sunflower oil; quinoline yellow; aerosil) - a sufficient amount to obtain a tablet weighing 0.18 g Valerian root extract dry (20 mg/tab). Vitamin Wb (1 mg/tab). Auxiliary components: sucrose, carrier - basic magnesium carbonate, potato starch, anti-caking agent: talc and magnesium stearate. Shell: thickener hydroxypropyl methyl cellulose, titanium dioxide dye, additional substance polyethylene glycol 6000, quinoline yellow dye. The daily volume of the product - 4 tablets - contains: vitamin WB - 4 mg, which corresponds to 200% of the recommended intake level, but will not exceed the upper limit permissible level consumption - 6 mg; valerenic acid - about 5 mcg, which is less than 0.3% of the adequate intake level.

Valerian extract indications for use

• - neurasthenia and conditions associated with prolonged neuropsychic agitation; - sleep disturbances due to overexcitation, nervous stress; - mild functional disorders of the cardiovascular system and digestive system(as part of complex therapy).

Valerian extract contraindications

• Hypersensitivity to the components of the drug (including bee products), sucrase/isomaltase deficiency, lactase deficiency, fructose intolerance, lactose intolerance, glucose-galactose malabsorption, childhood up to 12 years old. Use during pregnancy and during breastfeeding The use of the drug is contraindicated in the first trimester of pregnancy. The use of the drug in the second and third trimester of pregnancy and during breastfeeding is possible if the expected benefit to the mother outweighs the potential risk to the fetus and child. You should consult your doctor

Valerian extract dosage

• 20 mg 250 mg

Valerian extract side effects

• Possible lethargy, muscle weakness, drowsiness, decreased performance, and with prolonged use - constipation. In some cases, allergic reactions may develop.

Drug interactions

When used simultaneously with drugs that have a depressant effect on the central nervous system, their effect is potentiated.

Storage conditions

• store in a dry place
• store in a cool place 5-15 degrees
• store at room temperature 15-25 degrees
• keep away from children
• store in a place protected from light

Information provided

Valerian is a herbal medicine that has a mild sedative effect. Available in the form of a dry tablet extract. Basic driving force The drug is an essential oil, including bornyl isovalerianate and borneol acetate. Other components of the extract have a sedative effect - valepotriates (valtrate and isovaltrate), substances formed as a result of their breakdown (valtroxal, baldrinal, homobaldrinal) and a couple of alkaloids in the form of valerine and hotenin. Valerian extract helps immerse a person in natural normal sleep, protecting the body from external irritants. The sedative effect develops slowly, but is stable. Great value has the duration of the medication course and the regularity of use of the drug: otherwise, the sedative potential of valerian is almost completely neutralized. Valerian increases the affinity of GABA receptors for gamma-aminobutyric acid, which induces inhibition processes in the cortex cerebral hemispheres. It is characteristic that such an effect can be achieved exclusively with the use of valerian extract: its individual components (essential oil, valepotriates, sesquiterpenes) when administered in isolation do not cause sedation. The drug has a weak antispasmodic effect (especially in hyperkinetic biliary dyskinesia), has a choleretic effect, stimulates the secretory activity of the mucous membrane digestive tract, causes moderate bradycardia, increases the lumen of the coronary arteries.

The combination of natural compounds of the drug, using neurohumoral mechanisms and directly affecting the conduction system of the heart muscle, controls the activity of the heart: slows down its rhythm, ensures dilatation of the coronary arteries.

Valerian is indicated for increased excitability, somnological disorders, migraine headaches, lungs functional disorders cardiac activity and digestive system. Single dose– 1 tablet, frequency of administration – 2-3 times a day, peculiarity of administration – recommendation to drink 100 ml of water, best time reception - after meals. The duration of the therapeutic course is determined by the doctor individually. He also sets the optimal dose, guided by age, medical history and individual characteristics patient. The drug is well tolerated and has a favorable safety profile. Side effects appear mainly when taking high doses and are not serious: lethargy, decreased performance, constipation. In rare cases, allergies are possible. Valerian potentiates the effect sleeping pills, anxiolytics (anti-anxiety drugs), analgesics. Combinations with cardiotonics and antihypertensive drugs are possible. Valerian combines well with medications used to treat cardiovascular pathology and diseases of the digestive tract.

Pharmacology

Herbal product. Causes a moderate sedative effect. The action is due to the content of essential oil, most of which is an ester of borneol and isovaleric acid. Valepotriates and alkaloids - valerine and hotenin - also have sedative properties. Valerian facilitates the onset of natural sleep. The sedative effect manifests itself slowly, but quite steadily. Valeric acid and valepotriates have a weak antispasmodic effect. In addition, the complex is biologically active substances Valerian officinalis has a choleretic effect, enhances the secretory activity of the gastrointestinal mucosa, slows down heart rate and dilates the coronary vessels. Regulation of cardiac activity is mediated through neuroregulatory mechanisms and a direct effect on the automatism and conduction system of the heart. Therapeutic effect manifests itself with systematic and long-term course treatment.

Release form

10 pcs. - contour cellular packaging (2) - cardboard packs.
10 pcs. - contour cellular packaging (3) - cardboard packs.
10 pcs. - contour cellular packaging (5) - cardboard packs.
20 pcs. - cans (1) - cardboard packs.
25 pcs. - cans (1) - cardboard packs.
50 pcs. - cans (1) - cardboard packs.